THAP4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)5.37043019
2axonemal dynein complex assembly (GO:0070286)4.64567045
3interferon-gamma secretion (GO:0072643)4.57645914
4proline biosynthetic process (GO:0006561)4.49996374
5NADH metabolic process (GO:0006734)4.28812550
6negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)4.25782298
7motile cilium assembly (GO:0044458)4.15026762
8piRNA metabolic process (GO:0034587)4.07188362
9ribosomal large subunit biogenesis (GO:0042273)4.04330533
10protein maturation by protein folding (GO:0022417)3.93013301
11Golgi transport vesicle coating (GO:0048200)3.92564209
12COPI coating of Golgi vesicle (GO:0048205)3.92564209
13microtubule depolymerization (GO:0007019)3.88805191
14sperm-egg recognition (GO:0035036)3.88410127
15cilium or flagellum-dependent cell motility (GO:0001539)3.85500526
16DNA unwinding involved in DNA replication (GO:0006268)3.82630680
17binding of sperm to zona pellucida (GO:0007339)3.77748079
18epithelial cilium movement (GO:0003351)3.71730246
19protein complex localization (GO:0031503)3.71608260
20cellular protein complex localization (GO:0034629)3.66389186
21regulation of translational fidelity (GO:0006450)3.61419890
22nucleobase-containing small molecule interconversion (GO:0015949)3.59302666
23sperm motility (GO:0030317)3.57342121
24regulation of mammary gland epithelial cell proliferation (GO:0033599)3.54227186
25ribosomal small subunit assembly (GO:0000028)3.54031060
26spermatid development (GO:0007286)3.51941497
27heterochromatin organization (GO:0070828)3.50850739
28purine nucleobase biosynthetic process (GO:0009113)3.45755206
29fusion of sperm to egg plasma membrane (GO:0007342)3.44506929
30regulation of cilium movement (GO:0003352)3.41087259
31mitotic chromosome condensation (GO:0007076)3.40076958
32establishment of integrated proviral latency (GO:0075713)3.39897853
33gluconeogenesis (GO:0006094)3.38980236
34mitochondrial fusion (GO:0008053)3.38367983
35protein K6-linked ubiquitination (GO:0085020)3.37300707
36nucleobase biosynthetic process (GO:0046112)3.35176308
37cell-cell recognition (GO:0009988)3.33803312
38DNA replication initiation (GO:0006270)3.31698499
39ribonucleoprotein complex biogenesis (GO:0022613)3.30145854
40maturation of SSU-rRNA (GO:0030490)3.30020294
41peptidyl-arginine omega-N-methylation (GO:0035247)3.28681532
42cilium movement (GO:0003341)3.28086778
43monosaccharide biosynthetic process (GO:0046364)3.26763931
44synaptonemal complex assembly (GO:0007130)3.23986086
45synaptonemal complex organization (GO:0070193)3.23433945
46multicellular organism reproduction (GO:0032504)3.22972505
47ribosome biogenesis (GO:0042254)3.20804773
48cell wall macromolecule catabolic process (GO:0016998)3.18889860
49cell wall macromolecule metabolic process (GO:0044036)3.18889860
50hexose biosynthetic process (GO:0019319)3.18454470
51DNA replication checkpoint (GO:0000076)3.16606393
52termination of RNA polymerase III transcription (GO:0006386)3.16309697
53transcription elongation from RNA polymerase III promoter (GO:0006385)3.16309697
54guanosine-containing compound biosynthetic process (GO:1901070)3.15860894
55viral transcription (GO:0019083)3.14946612
56proline metabolic process (GO:0006560)3.14322919
57male meiosis (GO:0007140)3.13566877
58UTP biosynthetic process (GO:0006228)3.12928300
59GTP biosynthetic process (GO:0006183)3.12288490
60translational termination (GO:0006415)3.10928313
61negative regulation of cell size (GO:0045792)3.09052973
62tricarboxylic acid cycle (GO:0006099)3.08461647
63pentose-phosphate shunt (GO:0006098)3.07984638
64protein retention in ER lumen (GO:0006621)3.05428985
65maternal placenta development (GO:0001893)3.03945457
66maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.00964872
67IMP biosynthetic process (GO:0006188)3.00572718
68DNA strand elongation involved in DNA replication (GO:0006271)2.99066535
69regulation of nuclear cell cycle DNA replication (GO:0033262)2.98741430
70pseudouridine synthesis (GO:0001522)2.98167859
71male meiosis I (GO:0007141)2.95885380
72oxaloacetate metabolic process (GO:0006107)2.95828457
73pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.95824118
74rRNA catabolic process (GO:0016075)2.95613111
75protein targeting to ER (GO:0045047)2.94972794
76acrosome reaction (GO:0007340)2.93466825
77DNA methylation involved in gamete generation (GO:0043046)2.92788673
78spliceosomal tri-snRNP complex assembly (GO:0000244)2.92760302
79histone arginine methylation (GO:0034969)2.92144733
80cotranslational protein targeting to membrane (GO:0006613)2.90111439
81rRNA modification (GO:0000154)2.89904116
82NADPH regeneration (GO:0006740)2.88667266
83DNA strand elongation (GO:0022616)2.88586641
84telomere maintenance via semi-conservative replication (GO:0032201)2.88416611
85glucose catabolic process (GO:0006007)2.88017258
86IMP metabolic process (GO:0046040)2.87270449
87planar cell polarity pathway involved in neural tube closure (GO:0090179)2.87088909
88ribosome assembly (GO:0042255)2.87083737
89apoptotic process involved in morphogenesis (GO:0060561)2.86874044
90proteasome assembly (GO:0043248)2.86741006
91ribosomal small subunit biogenesis (GO:0042274)2.86393020
92translational initiation (GO:0006413)2.85182880
93rRNA metabolic process (GO:0016072)2.84577400
94viral life cycle (GO:0019058)2.84310365
95translational elongation (GO:0006414)2.84284113
96establishment of protein localization to endoplasmic reticulum (GO:0072599)2.82482327
97adherens junction assembly (GO:0034333)2.81564363
98regulation of translational termination (GO:0006449)2.81462625
99rRNA processing (GO:0006364)2.81105130
100formation of translation preinitiation complex (GO:0001731)2.79482664
101mitotic metaphase plate congression (GO:0007080)2.79350831
102protein localization to chromosome, centromeric region (GO:0071459)2.79231681
103protein localization to endoplasmic reticulum (GO:0070972)2.79207677
104negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.79160023
105retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.78385079
106nuclear pore organization (GO:0006999)2.76018965
107L-serine metabolic process (GO:0006563)2.75958967
108UTP metabolic process (GO:0046051)2.74825579
109pyrimidine nucleotide catabolic process (GO:0006244)2.74301123
110cell-substrate adherens junction assembly (GO:0007045)2.74284058
111focal adhesion assembly (GO:0048041)2.74284058
112chromosome organization involved in meiosis (GO:0070192)2.73756120
113folic acid metabolic process (GO:0046655)2.73270184
114tRNA methylation (GO:0030488)2.70614121
115regulation of early endosome to late endosome transport (GO:2000641)2.70432830
116rRNA transcription (GO:0009303)2.70308955
117meiosis I (GO:0007127)2.67136414
118cellular hyperosmotic response (GO:0071474)2.67098691
119regulation of mitochondrial translation (GO:0070129)2.65864765
120mitotic nuclear envelope reassembly (GO:0007084)2.65644482
121nuclear envelope reassembly (GO:0031468)2.65644482
122pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.65241090
123cullin deneddylation (GO:0010388)2.64866298
124cellular component biogenesis (GO:0044085)2.63842395
125establishment of viral latency (GO:0019043)2.63449784
126telomere maintenance via telomere lengthening (GO:0010833)2.61841557
127regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.60459112
128negative regulation of necroptotic process (GO:0060546)2.60431962
129tricarboxylic acid metabolic process (GO:0072350)2.60411225
130meiotic nuclear division (GO:0007126)2.59975325
131chromatin remodeling at centromere (GO:0031055)2.59807510
132organic cation transport (GO:0015695)2.58640473
133mitochondrial DNA replication (GO:0006264)2.58269934
134termination of RNA polymerase I transcription (GO:0006363)2.58252279
135glucose 6-phosphate metabolic process (GO:0051156)2.57954863
136intestinal epithelial cell development (GO:0060576)2.57755561
137cellular protein complex disassembly (GO:0043624)2.57062505
138chromosome condensation (GO:0030261)2.56847413
139translation (GO:0006412)2.56730999
140mitochondrial DNA metabolic process (GO:0032042)2.56724564
141nuclear pore complex assembly (GO:0051292)2.55936745
142SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.55519364
143glycolytic process (GO:0006096)2.55237179
1444-hydroxyproline metabolic process (GO:0019471)2.55006766
145pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.54924676
146pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.54810789
147ncRNA catabolic process (GO:0034661)2.54426730
148transcription from mitochondrial promoter (GO:0006390)2.54362302
149telomere maintenance via recombination (GO:0000722)2.54081358
150reciprocal meiotic recombination (GO:0007131)2.53961700
151reciprocal DNA recombination (GO:0035825)2.53961700
152peptidyl-arginine methylation (GO:0018216)2.53825187
153peptidyl-arginine N-methylation (GO:0035246)2.53825187
154meiotic chromosome segregation (GO:0045132)2.52816069
155reproduction (GO:0000003)2.52577454
156nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.52439085
157protein complex disassembly (GO:0043241)2.51059221
158negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.50832546
159negative regulation of DNA-templated transcription, elongation (GO:0032785)2.50832546
160CTP metabolic process (GO:0046036)2.50324553
161CTP biosynthetic process (GO:0006241)2.50324553
162regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.50002878
163acrosome assembly (GO:0001675)2.49978003
164deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.48349150
165folic acid-containing compound biosynthetic process (GO:0009396)2.48336973
166creatine metabolic process (GO:0006600)2.47283897
167GDP-mannose metabolic process (GO:0019673)2.43524893
168pentose metabolic process (GO:0019321)2.42182940
169heart trabecula formation (GO:0060347)2.39708970
170epithelial cell-cell adhesion (GO:0090136)2.38606091
171regulation of glucocorticoid metabolic process (GO:0031943)2.38458110
172pinocytosis (GO:0006907)2.36792827
173oxidative phosphorylation (GO:0006119)2.36641900
174endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.35651282
175protein targeting to membrane (GO:0006612)2.32959683
176positive regulation of DNA-dependent DNA replication (GO:2000105)2.32890392
177protein localization to endosome (GO:0036010)2.30397408
178convergent extension (GO:0060026)2.30363371

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.51432705
2MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse5.29369006
3* MYC_18555785_ChIP-Seq_MESCs_Mouse3.78857849
4* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.04825775
5CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.01342541
6EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.88340870
7MYC_19079543_ChIP-ChIP_MESCs_Mouse2.86062505
8MYC_18358816_ChIP-ChIP_MESCs_Mouse2.83597182
9KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.72792679
10FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.72721626
11ZNF263_19887448_ChIP-Seq_K562_Human2.60215215
12E2F4_17652178_ChIP-ChIP_JURKAT_Human2.58146333
13ETS1_20019798_ChIP-Seq_JURKAT_Human2.56971783
14MYC_19030024_ChIP-ChIP_MESCs_Mouse2.56966192
15PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.54745686
16GABP_17652178_ChIP-ChIP_JURKAT_Human2.51259114
17FOXM1_23109430_ChIP-Seq_U2OS_Human2.48341873
18NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.43102445
19EST1_17652178_ChIP-ChIP_JURKAT_Human2.39281600
20CREB1_15753290_ChIP-ChIP_HEK293T_Human2.24050768
21YY1_21170310_ChIP-Seq_MESCs_Mouse2.11113099
22MYC_22102868_ChIP-Seq_BL_Human2.07561678
23E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.06560890
24DCP1A_22483619_ChIP-Seq_HELA_Human2.06067109
25RARG_19884340_ChIP-ChIP_MEFs_Mouse2.00419134
26LXR_22292898_ChIP-Seq_THP-1_Human1.97415366
27XRN2_22483619_ChIP-Seq_HELA_Human1.91575904
28NANOG_18555785_ChIP-Seq_MESCs_Mouse1.85057838
29VDR_23849224_ChIP-Seq_CD4+_Human1.84043147
30RACK7_27058665_Chip-Seq_MCF-7_Human1.82230913
31NELFA_20434984_ChIP-Seq_ESCs_Mouse1.79588291
32ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.79429090
33FOXP3_21729870_ChIP-Seq_TREG_Human1.77696436
34* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.74838550
35ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.74198108
36* ELK3_25401928_ChIP-Seq_HUVEC_Human1.74004158
37* GABP_19822575_ChIP-Seq_HepG2_Human1.73665802
38MYCN_18555785_ChIP-Seq_MESCs_Mouse1.72844171
39VDR_21846776_ChIP-Seq_THP-1_Human1.71687507
40AR_21909140_ChIP-Seq_LNCAP_Human1.71680675
41MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.69960584
42STAT3_1855785_ChIP-Seq_MESCs_Mouse1.69868164
43ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.69625121
44CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.68212457
45ELF1_17652178_ChIP-ChIP_JURKAT_Human1.63750862
46THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.62283149
47* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.61625120
48TTF2_22483619_ChIP-Seq_HELA_Human1.61081495
49TP63_19390658_ChIP-ChIP_HaCaT_Human1.60913531
50HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.56608324
51MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.54852211
52POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.54807656
53SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.53551730
54* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.50189747
55SRF_21415370_ChIP-Seq_HL-1_Mouse1.49436464
56TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.49415159
57NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.47649346
58POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.47433715
59NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.46199339
60* ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.45384360
61CLOCK_20551151_ChIP-Seq_293T_Human1.41919628
62TP63_17297297_ChIP-ChIP_HaCaT_Human1.40138280
63KDM5A_27292631_Chip-Seq_BREAST_Human1.38152490
64KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.37964469
65CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.36507963
66* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.35416048
67POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.34681530
68KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.34332246
69PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.34322451
70TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.34149079
71CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.34040692
72SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.33830144
73SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.32762633
74FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.30746223
75SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.30430921
76KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.29429586
77DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.28373929
78E2F1_21310950_ChIP-Seq_MCF-7_Human1.26365404
79CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.25220145
80TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.23759451
81ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.22147587
82UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.20589994
83ZFP281_18757296_ChIP-ChIP_E14_Mouse1.19361883
84* ATF3_27146783_Chip-Seq_COLON_Human1.19221640
85KLF4_18555785_ChIP-Seq_MESCs_Mouse1.18842541
86P68_20966046_ChIP-Seq_HELA_Human1.17841834
87DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.16632790
88PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.15685990
89* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.14657607
90EGR1_19374776_ChIP-ChIP_THP-1_Human1.13081327
91RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.12847571
92TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.11635318
93KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.11587247
94SA1_27219007_Chip-Seq_ERYTHROID_Human1.11039021
95SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.10790492
96SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.10337015
97HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.10284486
98SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.10054169
99KDM2B_26808549_Chip-Seq_SUP-B15_Human1.09984109
100RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.09847044
101THAP11_20581084_ChIP-Seq_MESCs_Mouse1.09642728
102BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.09617727
103P300_27058665_Chip-Seq_ZR-75-30cells_Human1.08163371
104YY1_22570637_ChIP-Seq_MALME-3M_Human1.07269538
105SRY_22984422_ChIP-ChIP_TESTIS_Rat1.07208973
106CTCF_27219007_Chip-Seq_ERYTHROID_Human1.06448090
107ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.06064605
108KAP1_22055183_ChIP-Seq_ESCs_Mouse1.05871154
109HIF1A_21447827_ChIP-Seq_MCF-7_Human1.05837763
110OCT4_18692474_ChIP-Seq_MEFs_Mouse1.03179936
111ERG_21242973_ChIP-ChIP_JURKAT_Human1.03137370
112TBX5_21415370_ChIP-Seq_HL-1_Mouse1.02762663
113ELK1_19687146_ChIP-ChIP_HELA_Human1.02129978
114ELK1_22589737_ChIP-Seq_MCF10A_Human1.01946934
115KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.01597014
116KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.01597014
117KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.01597014
118TCF7_22412390_ChIP-Seq_EML_Mouse1.01568128
119RBPJ_22232070_ChIP-Seq_NCS_Mouse0.99486424
120NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.99245332
121KDM2B_26808549_Chip-Seq_DND41_Human0.98880607
122YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.98608008
123ESR1_15608294_ChIP-ChIP_MCF-7_Human0.98063429
124* FOXP1_21924763_ChIP-Seq_HESCs_Human0.97782982
125NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.97364741
126TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.96451625
127TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.94813260
128ERG_20887958_ChIP-Seq_HPC-7_Mouse0.94565956
129TET1_21451524_ChIP-Seq_MESCs_Mouse0.94211868
130CTCF_18555785_ChIP-Seq_MESCs_Mouse0.93044269
131MYC_18940864_ChIP-ChIP_HL60_Human0.91996218
132KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.88794052
133STAT1_20625510_ChIP-Seq_HELA_Human0.88011305
134HOXB4_20404135_ChIP-ChIP_EML_Mouse0.87555382
135NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.86150205
136ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.86000125
137SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.85509515
138E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.85069696
139PHF8_20622854_ChIP-Seq_HELA_Human0.84299896
140SOX2_18555785_ChIP-Seq_MESCs_Mouse0.84088209
141CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.83346478
142KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.82925984
143TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.82175499
144POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.81688467
145* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.80541771
146NOTCH1_21737748_ChIP-Seq_TLL_Human0.79780312
147TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.79021983
148CIITA_25753668_ChIP-Seq_RAJI_Human0.78629978

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization4.23793729
2MP0003705_abnormal_hypodermis_morpholog3.97268830
3MP0003693_abnormal_embryo_hatching3.90680783
4MP0004957_abnormal_blastocyst_morpholog3.41073569
5MP0003111_abnormal_nucleus_morphology3.02713314
6MP0000751_myopathy2.77561037
7MP0010094_abnormal_chromosome_stability2.76001621
8MP0003646_muscle_fatigue2.63669304
9MP0008058_abnormal_DNA_repair2.55286211
10MP0004185_abnormal_adipocyte_glucose2.53762839
11MP0003941_abnormal_skin_development2.36502363
12MP0003077_abnormal_cell_cycle2.35946877
13MP0008057_abnormal_DNA_replication2.35374721
14MP0001929_abnormal_gametogenesis2.24346794
15MP0010234_abnormal_vibrissa_follicle2.15199735
16MP0008932_abnormal_embryonic_tissue2.01388205
17MP0002210_abnormal_sex_determination2.00009804
18MP0001849_ear_inflammation1.99240829
19MP0000490_abnormal_crypts_of1.98958699
20MP0003878_abnormal_ear_physiology1.97936649
21MP0005377_hearing/vestibular/ear_phenot1.97936649
22MP0004858_abnormal_nervous_system1.95395634
23MP0003698_abnormal_male_reproductive1.94592283
24MP0008438_abnormal_cutaneous_collagen1.94131379
25MP0008877_abnormal_DNA_methylation1.94002475
26MP0010030_abnormal_orbit_morphology1.91066212
27MP0002877_abnormal_melanocyte_morpholog1.89349612
28MP0003718_maternal_effect1.89308060
29MP0000747_muscle_weakness1.85617139
30MP0009672_abnormal_birth_weight1.85261081
31MP0003786_premature_aging1.82033885
32MP0001145_abnormal_male_reproductive1.74971862
33MP0005058_abnormal_lysosome_morphology1.72652139
34MP0001661_extended_life_span1.71216324
35MP0000749_muscle_degeneration1.70300767
36MP0005330_cardiomyopathy1.68976663
37MP0000003_abnormal_adipose_tissue1.67739045
38MP0008007_abnormal_cellular_replicative1.66165946
39MP0004087_abnormal_muscle_fiber1.65300745
40MP0005076_abnormal_cell_differentiation1.60915043
41MP0005375_adipose_tissue_phenotype1.60568857
42MP0000759_abnormal_skeletal_muscle1.59769536
43MP0002132_abnormal_respiratory_system1.57697537
44MP0008260_abnormal_autophagy1.51377075
45MP0005670_abnormal_white_adipose1.50495561
46MP0000733_abnormal_muscle_development1.47592250
47MP0000653_abnormal_sex_gland1.47002838
48MP0003453_abnormal_keratinocyte_physiol1.44773474
49MP0003806_abnormal_nucleotide_metabolis1.43482566
50MP0004272_abnormal_basement_membrane1.42697165
51MP0005451_abnormal_body_composition1.41878915
52MP0009840_abnormal_foam_cell1.40872667
53MP0010630_abnormal_cardiac_muscle1.39510388
54MP0002009_preneoplasia1.38286465
55MP0002160_abnormal_reproductive_system1.36998894
56MP0002089_abnormal_postnatal_growth/wei1.30715710
57MP0005257_abnormal_intraocular_pressure1.27325345
58MP0003315_abnormal_perineum_morphology1.26544086
59MP0009379_abnormal_foot_pigmentation1.26030549
60MP0002277_abnormal_respiratory_mucosa1.24035323
61MP0002249_abnormal_larynx_morphology1.22401546
62MP0002653_abnormal_ependyma_morphology1.21775385
63MP0001672_abnormal_embryogenesis/_devel1.18032734
64MP0005380_embryogenesis_phenotype1.18032734
65MP0002269_muscular_atrophy1.17890166
66MP0001348_abnormal_lacrimal_gland1.17229341
67MP0003123_paternal_imprinting1.16692047
68MP0002396_abnormal_hematopoietic_system1.16202217
69MP0000566_synostosis1.15772543
70MP0001346_abnormal_lacrimal_gland1.14781472
71MP0000350_abnormal_cell_proliferation1.12828792
72MP0008004_abnormal_stomach_pH1.12536495
73MP0000613_abnormal_salivary_gland1.11306166
74MP0000013_abnormal_adipose_tissue1.10354614
75MP0002060_abnormal_skin_morphology1.09355132
76MP0002106_abnormal_muscle_physiology1.09174241
77MP0002161_abnormal_fertility/fecundity1.05689105
78MP0003828_pulmonary_edema1.05689005
79MP0006036_abnormal_mitochondrial_physio1.05427440
80MP0000750_abnormal_muscle_regeneration1.05404767
81MP0005501_abnormal_skin_physiology1.03793340
82MP0001730_embryonic_growth_arrest1.03317147
83MP0000467_abnormal_esophagus_morphology1.01518703
84MP0003984_embryonic_growth_retardation1.00949660
85MP0005623_abnormal_meninges_morphology0.99319115
86MP0004036_abnormal_muscle_relaxation0.99099780
87MP0005389_reproductive_system_phenotype0.98207273
88MP0002088_abnormal_embryonic_growth/wei0.96952185
89MP0000537_abnormal_urethra_morphology0.96498446
90MP0004264_abnormal_extraembryonic_tissu0.96083230
91MP0004233_abnormal_muscle_weight0.94606307
92MP0001697_abnormal_embryo_size0.93930102
93MP0006035_abnormal_mitochondrial_morpho0.93779157
94MP0000313_abnormal_cell_death0.93484637
95MP0009053_abnormal_anal_canal0.92780958
96MP0002085_abnormal_embryonic_tissue0.92734221
97MP0000462_abnormal_digestive_system0.92041388
98MP0005369_muscle_phenotype0.90517889
99MP0008995_early_reproductive_senescence0.89571877
100MP0000678_abnormal_parathyroid_gland0.89553233
101MP0002796_impaired_skin_barrier0.89540222
102MP0003942_abnormal_urinary_system0.89240261
103MP0002080_prenatal_lethality0.89087917
104MP0002098_abnormal_vibrissa_morphology0.88775338
105MP0009278_abnormal_bone_marrow0.88104379
106MP0003186_abnormal_redox_activity0.87226446
107MP0009333_abnormal_splenocyte_physiolog0.86571934
108MP0003567_abnormal_fetal_cardiomyocyte0.86496479
109MP0010352_gastrointestinal_tract_polyps0.86105265
110MP0000049_abnormal_middle_ear0.84933337
111MP0001119_abnormal_female_reproductive0.84845724
112MP0000477_abnormal_intestine_morphology0.83770388
113MP0010155_abnormal_intestine_physiology0.83111426
114MP0004019_abnormal_vitamin_homeostasis0.81875307
115MP0000762_abnormal_tongue_morphology0.80222953
116MP0005023_abnormal_wound_healing0.80149316
117MP0002086_abnormal_extraembryonic_tissu0.79946613
118MP0006138_congestive_heart_failure0.79631158
119MP0000579_abnormal_nail_morphology0.79128492
120MP0006292_abnormal_olfactory_placode0.78830672
121MP0001915_intracranial_hemorrhage0.78660763
122MP0000358_abnormal_cell_content/0.77288623
123MP0005621_abnormal_cell_physiology0.76945545
124MP0005397_hematopoietic_system_phenotyp0.76693113
125MP0001545_abnormal_hematopoietic_system0.76693113
126MP0002697_abnormal_eye_size0.76063353
127MP0004808_abnormal_hematopoietic_stem0.75129187
128MP0003866_abnormal_defecation0.74615550
129MP0002084_abnormal_developmental_patter0.74513649
130MP0001216_abnormal_epidermal_layer0.73773915
131MP0001764_abnormal_homeostasis0.72726990
132MP0002111_abnormal_tail_morphology0.72515356
133MP0002019_abnormal_tumor_incidence0.72212173
134MP0003937_abnormal_limbs/digits/tail_de0.70546302
135MP0005666_abnormal_adipose_tissue0.70481025
136MP0003936_abnormal_reproductive_system0.70433803
137MP0000858_altered_metastatic_potential0.70017344
138MP0004197_abnormal_fetal_growth/weight/0.69948825
139MP0005384_cellular_phenotype0.69932923
140MP0003136_yellow_coat_color0.69843766
141MP0002163_abnormal_gland_morphology0.69123751
142MP0002970_abnormal_white_adipose0.68571809
143MP0005395_other_phenotype0.67609017
144MP0004145_abnormal_muscle_electrophysio0.67520234
145MP0001919_abnormal_reproductive_system0.67367914
146MP0001756_abnormal_urination0.66907011
147MP0003566_abnormal_cell_adhesion0.66432883
148MP0001765_abnormal_ion_homeostasis0.66405642
149MP0003119_abnormal_digestive_system0.66117022
150MP0000534_abnormal_ureter_morphology0.65865968
151MP0000470_abnormal_stomach_morphology0.65283845
152MP0004133_heterotaxia0.64934076
153MP0009703_decreased_birth_body0.64694755
154MP0001663_abnormal_digestive_system0.63347055
155MP0004043_abnormal_pH_regulation0.63212965
156MP0001293_anophthalmia0.63050234
157MP0000538_abnormal_urinary_bladder0.60806625

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)5.91157513
2Dynein arm defect of respiratory motile cilia (HP:0012255)4.98927943
3Absent/shortened dynein arms (HP:0200106)4.98927943
4Abnormal respiratory motile cilium physiology (HP:0012261)4.36215608
5Abnormal respiratory motile cilium morphology (HP:0005938)4.16075623
6Abnormal respiratory epithelium morphology (HP:0012253)4.16075623
7Chronic bronchitis (HP:0004469)3.67527024
8Reticulocytopenia (HP:0001896)3.53901938
9Centrally nucleated skeletal muscle fibers (HP:0003687)3.53901283
10Abnormal ciliary motility (HP:0012262)3.53464292
11Exercise-induced myalgia (HP:0003738)3.52388085
12Myopathic facies (HP:0002058)3.51292029
13Rhinitis (HP:0012384)3.49527665
14Progressive muscle weakness (HP:0003323)3.44407403
15Chromosomal breakage induced by crosslinking agents (HP:0003221)3.41213541
16Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)3.40708032
17Muscle fiber inclusion bodies (HP:0100299)3.40201486
18Nemaline bodies (HP:0003798)3.38134532
19Type 1 muscle fiber predominance (HP:0003803)3.32357294
20Male infertility (HP:0003251)3.17315178
21Achilles tendon contracture (HP:0001771)3.15496687
22Chromsome breakage (HP:0040012)3.14895627
23Distal lower limb amyotrophy (HP:0008944)3.12241244
24Increased connective tissue (HP:0009025)3.07552168
25Abnormal spermatogenesis (HP:0008669)2.88259187
26Protrusio acetabuli (HP:0003179)2.84866516
27Abnormality of the Achilles tendon (HP:0005109)2.84847563
28Abnormality of skeletal muscle fiber size (HP:0012084)2.79154372
29Vertebral compression fractures (HP:0002953)2.77357706
30Cholecystitis (HP:0001082)2.76732052
31Abnormal gallbladder physiology (HP:0012438)2.76732052
32Impulsivity (HP:0100710)2.75525458
33Premature rupture of membranes (HP:0001788)2.71803694
34Nasal polyposis (HP:0100582)2.70138663
35Increased variability in muscle fiber diameter (HP:0003557)2.69827077
36Infertility (HP:0000789)2.67809137
37Hyperacusis (HP:0010780)2.66862864
38Ragged-red muscle fibers (HP:0003200)2.63487111
39Birth length less than 3rd percentile (HP:0003561)2.60700303
40Abnormality of the preputium (HP:0100587)2.58775942
41Testicular atrophy (HP:0000029)2.57374519
42Mildly elevated creatine phosphokinase (HP:0008180)2.51754264
43Aplasia/Hypoplasia of the sacrum (HP:0008517)2.50950551
44Spinal rigidity (HP:0003306)2.50307860
45Myoglobinuria (HP:0002913)2.45082435
46Bronchiectasis (HP:0002110)2.44828655
47Abnormality of glycolysis (HP:0004366)2.43731782
48Abnormal pancreas size (HP:0012094)2.43576613
49Oral leukoplakia (HP:0002745)2.40408208
50Absent thumb (HP:0009777)2.38973480
51Azoospermia (HP:0000027)2.37815205
52Generalized amyotrophy (HP:0003700)2.36694514
53Stridor (HP:0010307)2.35599677
54Gout (HP:0001997)2.35225387
55Rough bone trabeculation (HP:0100670)2.33480444
56Facial cleft (HP:0002006)2.26691492
57Ulnar bowing (HP:0003031)2.21253622
58Abnormality of chloride homeostasis (HP:0011422)2.20491653
59Pallor (HP:0000980)2.20145977
60Aplasia/Hypoplasia of the uvula (HP:0010293)2.19492993
61Meckel diverticulum (HP:0002245)2.17658296
62High anterior hairline (HP:0009890)2.15894650
63Distal lower limb muscle weakness (HP:0009053)2.15711160
64Lower limb amyotrophy (HP:0007210)2.14463030
65Abnormality of cells of the erythroid lineage (HP:0012130)2.12686171
66Breast hypoplasia (HP:0003187)2.12067590
67Macrocytic anemia (HP:0001972)2.09699664
68Nephronophthisis (HP:0000090)2.08097017
69Exercise-induced muscle cramps (HP:0003710)2.07656552
70Muscle stiffness (HP:0003552)2.07640830
71Abnormality of the nasal mucosa (HP:0000433)2.07382211
7211 pairs of ribs (HP:0000878)2.06343016
73Ventricular tachycardia (HP:0004756)2.05942044
74Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.04758274
75Decreased activity of mitochondrial respiratory chain (HP:0008972)2.04758274
76Abnormality of the ileum (HP:0001549)2.04350893
77Hyperglycinuria (HP:0003108)2.02908418
78Broad distal phalanx of finger (HP:0009836)2.01105841
79EMG: myopathic abnormalities (HP:0003458)2.00379516
80Trismus (HP:0000211)2.00281969
81Short nail (HP:0001799)1.99759632
82Axonal loss (HP:0003447)1.99510580
83Increased serum pyruvate (HP:0003542)1.99235348
84Abnormal trabecular bone morphology (HP:0100671)1.96469787
85Disproportionate tall stature (HP:0001519)1.95688656
86Breech presentation (HP:0001623)1.95429219
87Deep venous thrombosis (HP:0002625)1.94705291
88Ureteral duplication (HP:0000073)1.94206355
89Abnormality of the renal medulla (HP:0100957)1.93178639
90Upper limb amyotrophy (HP:0009129)1.92829316
91Distal upper limb amyotrophy (HP:0007149)1.92829316
92Selective tooth agenesis (HP:0001592)1.89932037
93Reticulocytosis (HP:0001923)1.89812912
94Hyperactive renin-angiotensin system (HP:0000841)1.89321335
95Neck muscle weakness (HP:0000467)1.89224378
96Round ear (HP:0100830)1.89143496
97Abnormal number of erythroid precursors (HP:0012131)1.88273082
98Dicarboxylic aciduria (HP:0003215)1.88062529
99Abnormality of dicarboxylic acid metabolism (HP:0010995)1.88062529
100Abnormal umbilical cord blood vessels (HP:0011403)1.87733757
101Single umbilical artery (HP:0001195)1.87733757
102Abnormality of the fetal cardiovascular system (HP:0010948)1.87733757
103Fragile skin (HP:0001030)1.86997493
104Proximal tubulopathy (HP:0000114)1.86879215
105Abnormality of the umbilical cord (HP:0010881)1.86330578
106Spinal cord compression (HP:0002176)1.85782387
107Cerebral aneurysm (HP:0004944)1.84709479
108Progressive external ophthalmoplegia (HP:0000590)1.83666413
109Ectopic kidney (HP:0000086)1.82485415
110Hepatic necrosis (HP:0002605)1.82440753
111Bulbar palsy (HP:0001283)1.82237572
112Abnormality of reticulocytes (HP:0004312)1.81542509
113Tubulointerstitial nephritis (HP:0001970)1.80894881
114Nephroblastoma (Wilms tumor) (HP:0002667)1.80791916
115Asymmetry of the thorax (HP:0001555)1.80458804
116Ulnar deviation of the wrist (HP:0003049)1.79543387
117Polyuria (HP:0000103)1.78295186
118Abnormality of chromosome stability (HP:0003220)1.78080387
119Muscle fiber splitting (HP:0003555)1.77380752
120Insulin resistance (HP:0000855)1.76932666
121Bronchitis (HP:0012387)1.76765556
122Abnormality of the calcaneus (HP:0008364)1.75829755
123Abnormality of alanine metabolism (HP:0010916)1.75622605
124Hyperalaninemia (HP:0003348)1.75622605
125Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.75622605
126Nausea (HP:0002018)1.75598452
127Sparse eyelashes (HP:0000653)1.75591314
128Ankle contracture (HP:0006466)1.73878179
129Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.73756228
130Colon cancer (HP:0003003)1.72976467
131Elbow flexion contracture (HP:0002987)1.72953934
132Ventricular fibrillation (HP:0001663)1.72775205
133Pancytopenia (HP:0001876)1.72731531
134Hypoglycemic coma (HP:0001325)1.71847126
135Exercise intolerance (HP:0003546)1.70957260
136Hepatocellular necrosis (HP:0001404)1.70264016
137Abnormalities of placenta or umbilical cord (HP:0001194)1.70072452
138Embryonal renal neoplasm (HP:0011794)1.69971016
139Pancreatic cysts (HP:0001737)1.69658011
140Congenital sensorineural hearing impairment (HP:0008527)1.69197474
141Exertional dyspnea (HP:0002875)1.68685747
142Supernumerary spleens (HP:0009799)1.68347771
143Abnormal hemoglobin (HP:0011902)1.68168599
144Calcaneovalgus deformity (HP:0001848)1.68140367
145Abnormality of carpal bone ossification (HP:0006257)1.67641896
146Sloping forehead (HP:0000340)1.66938819
147Long palpebral fissure (HP:0000637)1.66898157
148Abnormality of renal excretion (HP:0011036)1.65613220
149Duodenal stenosis (HP:0100867)1.65594842
150Small intestinal stenosis (HP:0012848)1.65594842
151Aplastic anemia (HP:0001915)1.65546120
152Ileus (HP:0002595)1.65081960
153Microvesicular hepatic steatosis (HP:0001414)1.65013941
154Bone marrow hypocellularity (HP:0005528)1.64802270
155Metabolic alkalosis (HP:0200114)1.64380493
156Insomnia (HP:0100785)1.64340549
157Rhabdomyolysis (HP:0003201)1.64106735
158Triphalangeal thumb (HP:0001199)1.63922555
159Unilateral renal agenesis (HP:0000122)1.63548620
160Abnormality of the distal phalanges of the toes (HP:0010182)1.62796255
161Advanced eruption of teeth (HP:0006288)1.62699707
162Slender build (HP:0001533)1.62323047
163Abnormality of the salivary glands (HP:0010286)1.62122958
164Pterygium (HP:0001059)1.62104790
165Cholelithiasis (HP:0001081)1.61152568
166Increased serum lactate (HP:0002151)1.60492795
167Premature ovarian failure (HP:0008209)1.59949560
168Nuclear cataract (HP:0100018)1.59341036
169Flat acetabular roof (HP:0003180)1.59111842
170Athetosis (HP:0002305)1.58803250
171Right ventricular cardiomyopathy (HP:0011663)1.58628981
172Difficulty climbing stairs (HP:0003551)1.58197179
173Abnormal urine output (HP:0012590)1.57188586
174Reduced subcutaneous adipose tissue (HP:0003758)1.56968792
175Duplicated collecting system (HP:0000081)1.56539631
176Multiple enchondromatosis (HP:0005701)1.55159269
177Abnormality of the tricuspid valve (HP:0001702)1.54960890
178Microglossia (HP:0000171)1.54278378
179Back pain (HP:0003418)1.53550822
180Abnormality of the thoracic spine (HP:0100711)1.51803841
181Renal duplication (HP:0000075)1.49757155
182Partial duplication of thumb phalanx (HP:0009944)1.49460388
183Blue sclerae (HP:0000592)1.49127754

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB34.20687469
2SMG13.75797331
3PDK33.62873441
4PDK43.62873441
5STK38L3.50675040
6BUB13.10566496
7STK162.86314117
8NME22.82472147
9EPHA22.72034210
10NEK22.53750693
11TESK12.40506779
12WEE12.35209242
13PDK22.26765194
14ERN12.12934982
15VRK22.11824116
16PRPF4B2.02711087
17ICK1.99330588
18EIF2AK11.94934041
19TTK1.93016571
20SIK11.92649135
21PLK41.89389268
22ZAK1.88139907
23NME11.84286464
24PASK1.78639311
25TAOK21.73005504
26PIM21.72328690
27NUAK11.71290328
28LMTK21.63273334
29MAP3K101.62351190
30ARAF1.59019012
31TLK11.50515502
32WNK31.49956114
33PRKG21.47381874
34DYRK31.43070871
35MST1R1.41525952
36BRSK21.36527680
37PHKG11.35850440
38PHKG21.35850440
39MST41.33615368
40PLK11.31903410
41WNK41.29117427
42PKN21.28851187
43IRAK31.28588721
44CDK71.28432183
45CDC71.24571999
46MAP2K21.24090080
47MKNK21.23510198
48MAP3K111.23032450
49SRPK11.20456574
50AURKB1.18511762
51PBK1.18415297
52RPS6KA41.11800535
53CHEK21.11303489
54PTK21.05423958
55RPS6KB21.04373424
56CDK41.03653792
57TAOK11.01627180
58MAP3K30.99511573
59RIPK10.99101993
60TEC0.98244172
61SCYL20.96617363
62FGFR40.94034095
63DMPK0.93561824
64ATR0.92731870
65BCKDK0.92588407
66OBSCN0.92491162
67PRKD30.91382465
68AURKA0.90900765
69BRAF0.90400926
70MTOR0.88841178
71STK30.88831379
72PIM10.86869369
73EEF2K0.85490974
74PDGFRA0.84643203
75MAPK150.83300982
76CDK120.81435530
77CDK80.81302066
78MAP3K90.80647978
79PTK60.79694989
80MET0.79645612
81NTRK10.78950971
82IRAK20.78000943
83BRSK10.77860917
84TESK20.76725738
85MYLK0.76260658
86LIMK10.75425008
87PRKCI0.74370032
88STK240.72101534
89KSR20.71581659
90MKNK10.71400202
91BMX0.70316360
92PINK10.70314769
93ABL20.69853968
94LRRK20.69490282
95STK380.69100397
96MAP3K10.67634198
97EPHB20.67112737
98DYRK1B0.66067324
99EIF2AK30.66016820
100PAK40.64693093
101PRKD20.64215940
102GRK10.63786450
103MARK30.63528204
104STK40.61600387
105CHEK10.61522726
106DAPK10.60851491
107MAP3K130.58714014
108VRK10.57517011
109DAPK30.56557634
110PAK20.56504069
111PAK10.56132323
112EIF2AK20.55992515
113NEK10.55464641
114LATS10.54632419
115ILK0.53927410
116STK100.53803212
117MAP3K70.53785476
118MAPK110.53280806
119TTN0.51807861
120MAP2K60.51460069
121CSNK2A10.51205315
122MAPKAPK30.49595215
123DDR20.48491585
124ADRBK20.47421435
125PIK3CA0.47297664
126ATM0.46364529
127AKT20.46040120
128EPHB10.45920157
129MAP3K80.44177484
130STK390.43588552
131BRD40.42978016
132PDPK10.42579508
133TSSK60.42166020
134LATS20.41640051
135TXK0.41397540
136AKT30.39976920
137ACVR1B0.39421258
138CSNK2A20.38558771
139KDR0.37620916
140CDK11A0.37142150
141CDK90.35601011
142YES10.35498924
143PLK30.35195053
144MAP4K10.34776749
145MOS0.33528303
146RPS6KL10.33251357
147RPS6KC10.33251357
148CDC42BPA0.32951911
149RAF10.31851223
150MAP2K30.31412404
151CDK20.31089019

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030103.63144339
2DNA replication_Homo sapiens_hsa030303.60650249
3RNA polymerase_Homo sapiens_hsa030203.36296393
4Mismatch repair_Homo sapiens_hsa034303.05948057
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.04267183
6Homologous recombination_Homo sapiens_hsa034402.74661612
7Pyrimidine metabolism_Homo sapiens_hsa002402.68406126
8Base excision repair_Homo sapiens_hsa034102.56677676
9Proteasome_Homo sapiens_hsa030502.52289094
10Fanconi anemia pathway_Homo sapiens_hsa034602.50780493
11RNA transport_Homo sapiens_hsa030132.32763195
12Vitamin B6 metabolism_Homo sapiens_hsa007502.21244844
13Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.05339265
14Spliceosome_Homo sapiens_hsa030402.01797496
15Nucleotide excision repair_Homo sapiens_hsa034201.95022625
16One carbon pool by folate_Homo sapiens_hsa006701.91639707
17Basal transcription factors_Homo sapiens_hsa030221.82868187
18Cell cycle_Homo sapiens_hsa041101.81806986
19Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.76261857
20Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.74219832
21Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.71404837
22Fatty acid elongation_Homo sapiens_hsa000621.70383357
23Purine metabolism_Homo sapiens_hsa002301.68055091
24Huntingtons disease_Homo sapiens_hsa050161.66261861
25Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.59524753
26Central carbon metabolism in cancer_Homo sapiens_hsa052301.59468051
27Oxidative phosphorylation_Homo sapiens_hsa001901.48969983
28Pentose phosphate pathway_Homo sapiens_hsa000301.41102658
29Parkinsons disease_Homo sapiens_hsa050121.38602740
30RNA degradation_Homo sapiens_hsa030181.34298457
31Arachidonic acid metabolism_Homo sapiens_hsa005901.34072723
32p53 signaling pathway_Homo sapiens_hsa041151.32459154
33Phenylalanine metabolism_Homo sapiens_hsa003601.31393667
34Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.30902500
35Thyroid cancer_Homo sapiens_hsa052161.26482701
36Bladder cancer_Homo sapiens_hsa052191.22129955
37Fructose and mannose metabolism_Homo sapiens_hsa000511.21970086
38Folate biosynthesis_Homo sapiens_hsa007901.21365350
39Selenocompound metabolism_Homo sapiens_hsa004501.16973188
40Linoleic acid metabolism_Homo sapiens_hsa005911.15953792
41Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.15853912
42Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.13103951
43Glutathione metabolism_Homo sapiens_hsa004801.10044429
44alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.09829428
45Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.09175824
46Arginine biosynthesis_Homo sapiens_hsa002201.08318698
47Carbon metabolism_Homo sapiens_hsa012001.08089421
48Fatty acid metabolism_Homo sapiens_hsa012121.07916110
49mRNA surveillance pathway_Homo sapiens_hsa030151.06901359
50Vitamin digestion and absorption_Homo sapiens_hsa049771.05303520
51Chronic myeloid leukemia_Homo sapiens_hsa052201.02445068
52N-Glycan biosynthesis_Homo sapiens_hsa005101.00574441
53Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.99405809
54Cyanoamino acid metabolism_Homo sapiens_hsa004600.99401380
55Prion diseases_Homo sapiens_hsa050200.94950954
56Insulin signaling pathway_Homo sapiens_hsa049100.94725463
57Sulfur relay system_Homo sapiens_hsa041220.91796846
58Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.88484151
59Herpes simplex infection_Homo sapiens_hsa051680.88154410
60Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.87717559
61Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.86793095
62Intestinal immune network for IgA production_Homo sapiens_hsa046720.86022659
63Epstein-Barr virus infection_Homo sapiens_hsa051690.83258722
64Galactose metabolism_Homo sapiens_hsa000520.82979984
65Propanoate metabolism_Homo sapiens_hsa006400.82684758
66AMPK signaling pathway_Homo sapiens_hsa041520.79748450
67Legionellosis_Homo sapiens_hsa051340.78562820
68Pyruvate metabolism_Homo sapiens_hsa006200.77492810
69Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.76152182
70Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.73782756
71Vibrio cholerae infection_Homo sapiens_hsa051100.71293619
72Cysteine and methionine metabolism_Homo sapiens_hsa002700.70135442
73Glucagon signaling pathway_Homo sapiens_hsa049220.69838385
74Lysine degradation_Homo sapiens_hsa003100.69108553
75Fatty acid biosynthesis_Homo sapiens_hsa000610.68921834
76Acute myeloid leukemia_Homo sapiens_hsa052210.68588086
77Notch signaling pathway_Homo sapiens_hsa043300.67487939
78Pentose and glucuronate interconversions_Homo sapiens_hsa000400.66277329
79Arginine and proline metabolism_Homo sapiens_hsa003300.65700025
80Other glycan degradation_Homo sapiens_hsa005110.65316074
81Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.65192646
82Cardiac muscle contraction_Homo sapiens_hsa042600.64773505
83Alzheimers disease_Homo sapiens_hsa050100.63433015
84Metabolic pathways_Homo sapiens_hsa011000.63180444
85Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.62648732
86Non-small cell lung cancer_Homo sapiens_hsa052230.59429170
87Endometrial cancer_Homo sapiens_hsa052130.57605071
88Mineral absorption_Homo sapiens_hsa049780.57165774
89Thyroid hormone signaling pathway_Homo sapiens_hsa049190.56753370
90Pancreatic cancer_Homo sapiens_hsa052120.56000434
91NF-kappa B signaling pathway_Homo sapiens_hsa040640.55749016
92Regulation of autophagy_Homo sapiens_hsa041400.55498894
93Longevity regulating pathway - mammal_Homo sapiens_hsa042110.53350965
94mTOR signaling pathway_Homo sapiens_hsa041500.51932489
95Biosynthesis of amino acids_Homo sapiens_hsa012300.51170106
96Non-homologous end-joining_Homo sapiens_hsa034500.51124069
97Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.50549928
98VEGF signaling pathway_Homo sapiens_hsa043700.50392064
99Antigen processing and presentation_Homo sapiens_hsa046120.50386766
100Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.48627922
101Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.48000329
102Protein export_Homo sapiens_hsa030600.47112015
103Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.46956439
104Measles_Homo sapiens_hsa051620.46667149
105Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.45457864
106Basal cell carcinoma_Homo sapiens_hsa052170.45213384
107Drug metabolism - other enzymes_Homo sapiens_hsa009830.43932262
108Glycosaminoglycan degradation_Homo sapiens_hsa005310.43715768
109Proteoglycans in cancer_Homo sapiens_hsa052050.43319056
110Hippo signaling pathway_Homo sapiens_hsa043900.41256532
111Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.41181218
112HIF-1 signaling pathway_Homo sapiens_hsa040660.40781678
113Insulin resistance_Homo sapiens_hsa049310.39724076
114Tight junction_Homo sapiens_hsa045300.39704680
115Tyrosine metabolism_Homo sapiens_hsa003500.39029046
116Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.38348778
117Focal adhesion_Homo sapiens_hsa045100.38136772
118Glioma_Homo sapiens_hsa052140.38079113
119Small cell lung cancer_Homo sapiens_hsa052220.37992908
120Glycerophospholipid metabolism_Homo sapiens_hsa005640.37633725
121Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.37339598
122HTLV-I infection_Homo sapiens_hsa051660.36925617
123Colorectal cancer_Homo sapiens_hsa052100.36085066
124Sulfur metabolism_Homo sapiens_hsa009200.35615174
1252-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.35387651
126Fat digestion and absorption_Homo sapiens_hsa049750.34995621
127NOD-like receptor signaling pathway_Homo sapiens_hsa046210.34756804
128Adipocytokine signaling pathway_Homo sapiens_hsa049200.34091485
129Dilated cardiomyopathy_Homo sapiens_hsa054140.33765147
130Protein digestion and absorption_Homo sapiens_hsa049740.33616451
131Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.33073082
132Sphingolipid metabolism_Homo sapiens_hsa006000.32344514
133Steroid biosynthesis_Homo sapiens_hsa001000.32014262
134Viral carcinogenesis_Homo sapiens_hsa052030.30497815
135Hedgehog signaling pathway_Homo sapiens_hsa043400.30319190
136Fatty acid degradation_Homo sapiens_hsa000710.29985277
137Adherens junction_Homo sapiens_hsa045200.29971228
138Transcriptional misregulation in cancer_Homo sapiens_hsa052020.29892597
139Maturity onset diabetes of the young_Homo sapiens_hsa049500.29099990
140Influenza A_Homo sapiens_hsa051640.28731343
141RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.28477995
142Renin-angiotensin system_Homo sapiens_hsa046140.26696391
143Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.22653564
144Retinol metabolism_Homo sapiens_hsa008300.21737237
145Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.21001116
146Allograft rejection_Homo sapiens_hsa053300.20523052
147Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.20294849
148Asthma_Homo sapiens_hsa053100.19674818
149Apoptosis_Homo sapiens_hsa042100.19466621

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