THAP10

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of a family of proteins sharing an N-terminal Thanatos-associated domain. The Thanatos-associated domain contains a zinc finger signature similar to DNA-binding domains. This gene is part of a bidirectional gene pair on the long arm of chromosome 15 that is regulated by estrogen and may play a role in breast cancer. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1CENP-A containing nucleosome assembly (GO:0034080)4.36178443
2chromatin remodeling at centromere (GO:0031055)4.30161334
3DNA double-strand break processing (GO:0000729)3.93324109
4proteasome assembly (GO:0043248)3.70890612
5telomere maintenance via semi-conservative replication (GO:0032201)3.66092863
6histone exchange (GO:0043486)3.64340988
7mitotic metaphase plate congression (GO:0007080)3.57104998
8kinetochore organization (GO:0051383)3.55998142
9metaphase plate congression (GO:0051310)3.55925938
10DNA strand elongation involved in DNA replication (GO:0006271)3.46199980
11cullin deneddylation (GO:0010388)3.42482538
12regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.41953350
13DNA replication-independent nucleosome assembly (GO:0006336)3.39220760
14DNA replication-independent nucleosome organization (GO:0034724)3.39220760
15nucleotide-excision repair, DNA gap filling (GO:0006297)3.37020963
16DNA replication checkpoint (GO:0000076)3.36463432
17protein localization to kinetochore (GO:0034501)3.34803026
18DNA strand elongation (GO:0022616)3.32770737
19sister chromatid segregation (GO:0000819)3.28737410
20DNA ligation (GO:0006266)3.22495983
21mitotic chromosome condensation (GO:0007076)3.21302225
22protein deneddylation (GO:0000338)3.21249051
23protein K6-linked ubiquitination (GO:0085020)3.19560975
24establishment of integrated proviral latency (GO:0075713)3.18803763
25kinetochore assembly (GO:0051382)3.18248281
26protein localization to chromosome, centromeric region (GO:0071459)3.16686110
27microtubule polymerization or depolymerization (GO:0031109)3.16344192
28mitotic sister chromatid segregation (GO:0000070)3.14424390
29regulation of centriole replication (GO:0046599)3.13358302
30regulation of spindle organization (GO:0090224)3.12865080
31microtubule depolymerization (GO:0007019)3.12371914
32regulation of mitotic spindle organization (GO:0060236)3.11437719
33L-serine metabolic process (GO:0006563)3.04626812
34mitotic recombination (GO:0006312)2.96340359
35deoxyribonucleotide biosynthetic process (GO:0009263)2.95021663
36postreplication repair (GO:0006301)2.92141191
37establishment of chromosome localization (GO:0051303)2.91461424
38telomere maintenance via recombination (GO:0000722)2.91108357
39spindle checkpoint (GO:0031577)2.91064093
40protein localization to chromosome (GO:0034502)2.90289115
41negative regulation of DNA-dependent DNA replication (GO:2000104)2.87441211
42intraciliary transport (GO:0042073)2.83626902
43negative regulation of meiosis (GO:0045835)2.79542967
44negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.77922134
45negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.77922134
46negative regulation of mitotic sister chromatid segregation (GO:0033048)2.77922134
47negative regulation of mitotic sister chromatid separation (GO:2000816)2.77922134
48negative regulation of sister chromatid segregation (GO:0033046)2.77922134
49negative regulation of chromosome segregation (GO:0051985)2.76785373
50histone H2A acetylation (GO:0043968)2.74182227
51DNA damage response, detection of DNA damage (GO:0042769)2.73716407
52regulation of DNA endoreduplication (GO:0032875)2.73294588
53ventricular cardiac muscle cell development (GO:0055015)2.73096735
54mitotic spindle checkpoint (GO:0071174)2.72053121
55DNA replication-dependent nucleosome assembly (GO:0006335)2.70410286
56DNA replication-dependent nucleosome organization (GO:0034723)2.70410286
57DNA catabolic process, exonucleolytic (GO:0000738)2.70383091
58DNA unwinding involved in DNA replication (GO:0006268)2.70067441
59anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.66871796
60regulation of chromosome segregation (GO:0051983)2.63482760
61mitotic spindle assembly checkpoint (GO:0007094)2.62611512
62spindle assembly checkpoint (GO:0071173)2.60557610
63mitotic sister chromatid cohesion (GO:0007064)2.59482994
64negative regulation of microtubule depolymerization (GO:0007026)2.57479544
65deoxyribose phosphate biosynthetic process (GO:0046385)2.56732696
662-deoxyribonucleotide biosynthetic process (GO:0009265)2.56732696
67regulation of double-strand break repair via homologous recombination (GO:0010569)2.56445016
68regulation of nuclear cell cycle DNA replication (GO:0033262)2.56162663
69telomere maintenance via telomere lengthening (GO:0010833)2.54480473
70mitotic spindle organization (GO:0007052)2.54388760
71attachment of spindle microtubules to kinetochore (GO:0008608)2.53428758
72regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.50627063
73regulation of mitotic metaphase/anaphase transition (GO:0030071)2.50627063
74translesion synthesis (GO:0019985)2.47950372
75regulation of sister chromatid segregation (GO:0033045)2.47685161
76regulation of mitotic sister chromatid separation (GO:0010965)2.47685161
77regulation of mitotic sister chromatid segregation (GO:0033047)2.47685161
78somatic hypermutation of immunoglobulin genes (GO:0016446)2.44398341
79somatic diversification of immune receptors via somatic mutation (GO:0002566)2.44398341
80ATP-dependent chromatin remodeling (GO:0043044)2.43979222
81establishment of viral latency (GO:0019043)2.43130092
82L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.41985339
83regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.41337557
84chromosome condensation (GO:0030261)2.39900247
85maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.39221724
86base-excision repair (GO:0006284)2.38256365
87positive regulation of mitochondrial fission (GO:0090141)2.38107207
88resolution of meiotic recombination intermediates (GO:0000712)2.38011970
89regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.35726831
90negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.35535815
91negative regulation of DNA recombination (GO:0045910)2.35474816
92regulation of microtubule depolymerization (GO:0031114)2.34656353
93DNA replication initiation (GO:0006270)2.33274110
94negative regulation of mitosis (GO:0045839)2.32214480
95regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.31107175
96regulation of mitotic spindle checkpoint (GO:1903504)2.31107175
97chromosome segregation (GO:0007059)2.30949318
98mitotic cell cycle (GO:0000278)2.30549843
99negative regulation of nuclear division (GO:0051784)2.30525147
100centriole replication (GO:0007099)2.26860340

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.36683007
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.19071889
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.86124408
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.59300845
5FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.04097758
6MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.95702530
7SALL1_21062744_ChIP-ChIP_HESCs_Human2.88961131
8NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.75352486
9AR_21909140_ChIP-Seq_LNCAP_Human2.71896702
10GABP_17652178_ChIP-ChIP_JURKAT_Human2.62793759
11MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.62422379
12CREB1_15753290_ChIP-ChIP_HEK293T_Human2.53689509
13MYC_18555785_ChIP-Seq_MESCs_Mouse2.27304356
14PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.23966959
15NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.22830395
16EST1_17652178_ChIP-ChIP_JURKAT_Human2.11331515
17HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.04695464
18JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.02371362
19THAP11_20581084_ChIP-Seq_MESCs_Mouse2.00891714
20HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.00206470
21CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.97575550
22E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.95986981
23ETS1_20019798_ChIP-Seq_JURKAT_Human1.89151716
24KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.84782807
25NELFA_20434984_ChIP-Seq_ESCs_Mouse1.79806495
26DCP1A_22483619_ChIP-Seq_HELA_Human1.75239804
27* TAF15_26573619_Chip-Seq_HEK293_Human1.65861843
28MYC_19030024_ChIP-ChIP_MESCs_Mouse1.65723318
29MYCN_18555785_ChIP-Seq_MESCs_Mouse1.64113919
30ELK1_19687146_ChIP-ChIP_HELA_Human1.63793147
31CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.63353780
32GBX2_23144817_ChIP-Seq_PC3_Human1.59246345
33GABP_19822575_ChIP-Seq_HepG2_Human1.58456598
34* E2F1_21310950_ChIP-Seq_MCF-7_Human1.56109342
35E2F1_18555785_ChIP-Seq_MESCs_Mouse1.53582203
36PADI4_21655091_ChIP-ChIP_MCF-7_Human1.53011178
37POU3F2_20337985_ChIP-ChIP_501MEL_Human1.51589374
38PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.49575722
39MYC_18940864_ChIP-ChIP_HL60_Human1.49274763
40MYC_18358816_ChIP-ChIP_MESCs_Mouse1.48904978
41ZNF274_21170338_ChIP-Seq_K562_Hela1.43612239
42YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.42521097
43TTF2_22483619_ChIP-Seq_HELA_Human1.39851765
44EWS_26573619_Chip-Seq_HEK293_Human1.38749314
45FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.38121151
46XRN2_22483619_ChIP-Seq_HELA_Human1.37434554
47FUS_26573619_Chip-Seq_HEK293_Human1.37141175
48ZFX_18555785_ChIP-Seq_MESCs_Mouse1.36727203
49VDR_23849224_ChIP-Seq_CD4+_Human1.33848862
50ZFP57_27257070_Chip-Seq_ESCs_Mouse1.30493033
51ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.30022097
52PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.30019826
53POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.29475857
54MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.27511923
55POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.24567888
56CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.23050038
57EZH2_22144423_ChIP-Seq_EOC_Human1.21485566
58MYC_19079543_ChIP-ChIP_MESCs_Mouse1.21269978
59POU5F1_16153702_ChIP-ChIP_HESCs_Human1.20588291
60EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.18348148
61NANOG_18555785_ChIP-Seq_MESCs_Mouse1.17146311
62* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.15369897
63IRF1_19129219_ChIP-ChIP_H3396_Human1.13740896
64CTBP2_25329375_ChIP-Seq_LNCAP_Human1.12671543
65SOX2_18555785_ChIP-Seq_MESCs_Mouse1.11288780
66YY1_21170310_ChIP-Seq_MESCs_Mouse1.10393124
67FOXP3_21729870_ChIP-Seq_TREG_Human1.09184746
68IGF1R_20145208_ChIP-Seq_DFB_Human1.07356706
69TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.07264292
70FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.05682673
71CTBP1_25329375_ChIP-Seq_LNCAP_Human1.05209671
72RNF2_27304074_Chip-Seq_NSC_Mouse1.03727009
73* NANOG_16153702_ChIP-ChIP_HESCs_Human1.03619627
74SOX9_26525672_Chip-Seq_HEART_Mouse1.02855959
75CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.00956130
76NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.00129104
77CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.99757379
78CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.99602323
79RBPJ_22232070_ChIP-Seq_NCS_Mouse0.97495876
80CBX2_27304074_Chip-Seq_ESCs_Mouse0.97258717
81SOX2_16153702_ChIP-ChIP_HESCs_Human0.97099822
82P300_19829295_ChIP-Seq_ESCs_Human0.95890174
83MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.93909957
84SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.93790352
85SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.92262957
86RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.91243786
87HTT_18923047_ChIP-ChIP_STHdh_Human0.89427181
88SOX17_20123909_ChIP-Seq_XEN_Mouse0.89252960
89REST_19997604_ChIP-ChIP_NEURONS_Mouse0.88460661
90BMI1_23680149_ChIP-Seq_NPCS_Mouse0.85655661
91WT1_19549856_ChIP-ChIP_CCG9911_Human0.83578473
92ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.83211176
93SRF_21415370_ChIP-Seq_HL-1_Mouse0.82225393
94CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.82137013
95HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.81004389
96OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.80742723
97ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.80019544
98POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.79995638
99VDR_22108803_ChIP-Seq_LS180_Human0.79051174
100JUN_21703547_ChIP-Seq_K562_Human0.78022792

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008058_abnormal_DNA_repair3.15813806
2MP0010094_abnormal_chromosome_stability3.01347442
3MP0003111_abnormal_nucleus_morphology2.36678510
4MP0003693_abnormal_embryo_hatching2.34496532
5MP0008932_abnormal_embryonic_tissue2.22993115
6MP0008789_abnormal_olfactory_epithelium2.08154579
7MP0004957_abnormal_blastocyst_morpholog2.02203987
8MP0003880_abnormal_central_pattern2.01720501
9MP0003077_abnormal_cell_cycle2.01542252
10MP0003890_abnormal_embryonic-extraembry1.96066472
11MP0009046_muscle_twitch1.94414798
12MP0001529_abnormal_vocalization1.93536163
13MP0004859_abnormal_synaptic_plasticity1.89117057
14MP0010030_abnormal_orbit_morphology1.86276081
15MP0001188_hyperpigmentation1.79772057
16MP0002234_abnormal_pharynx_morphology1.75552627
17MP0002102_abnormal_ear_morphology1.74160455
18MP0005623_abnormal_meninges_morphology1.65248578
19MP0005394_taste/olfaction_phenotype1.63544807
20MP0005499_abnormal_olfactory_system1.63544807
21MP0008057_abnormal_DNA_replication1.61664206
22MP0008877_abnormal_DNA_methylation1.59483077
23MP0000049_abnormal_middle_ear1.57279919
24MP0002233_abnormal_nose_morphology1.57269987
25MP0003937_abnormal_limbs/digits/tail_de1.53983765
26MP0003718_maternal_effect1.52964024
27MP0000566_synostosis1.50280801
28MP0003119_abnormal_digestive_system1.47461140
29MP0002736_abnormal_nociception_after1.42369794
30MP0003121_genomic_imprinting1.38289942
31MP0005248_abnormal_Harderian_gland1.37310649
32MP0004270_analgesia1.35004849
33MP0003635_abnormal_synaptic_transmissio1.33875911
34MP0001984_abnormal_olfaction1.30463861
35MP0000778_abnormal_nervous_system1.30313872
36MP0002272_abnormal_nervous_system1.28521622
37MP0001346_abnormal_lacrimal_gland1.28192190
38MP0001177_atelectasis1.27881931
39MP0006292_abnormal_olfactory_placode1.26190103
40MP0001293_anophthalmia1.24902933
41MP0009745_abnormal_behavioral_response1.23957952
42MP0003861_abnormal_nervous_system1.19570210
43MP0001968_abnormal_touch/_nociception1.16897681
44MP0003787_abnormal_imprinting1.15455495
45MP0003755_abnormal_palate_morphology1.15112320
46MP0002160_abnormal_reproductive_system1.15056238
47MP0002210_abnormal_sex_determination1.11165852
48MP0001486_abnormal_startle_reflex1.10664987
49MP0004811_abnormal_neuron_physiology1.10409117
50MP0002063_abnormal_learning/memory/cond1.09888581
51MP0006276_abnormal_autonomic_nervous1.09678069
52MP0003941_abnormal_skin_development1.09493433
53MP0002184_abnormal_innervation1.08684296
54MP0002572_abnormal_emotion/affect_behav1.06054024
55MP0003122_maternal_imprinting1.04953481
56MP0003385_abnormal_body_wall1.04837131
57MP0001929_abnormal_gametogenesis1.03870082
58MP0002085_abnormal_embryonic_tissue1.02401539
59MP0002938_white_spotting0.99812087
60MP0006072_abnormal_retinal_apoptosis0.99538912
61MP0002064_seizures0.99468931
62MP0008007_abnormal_cellular_replicative0.98794087
63MP0002084_abnormal_developmental_patter0.97611779
64MP0000955_abnormal_spinal_cord0.96484033
65MP0001286_abnormal_eye_development0.95867375
66MP0002735_abnormal_chemical_nociception0.95459858
67MP0002751_abnormal_autonomic_nervous0.95307247
68MP0001299_abnormal_eye_distance/0.94763320
69MP0001730_embryonic_growth_arrest0.94171201
70MP0004133_heterotaxia0.93232666
71MP0002734_abnormal_mechanical_nocicepti0.92489081
72MP0003698_abnormal_male_reproductive0.92009665
73MP0002882_abnormal_neuron_morphology0.90050653
74MP0001145_abnormal_male_reproductive0.89539980
75MP0002697_abnormal_eye_size0.88745522
76MP0009053_abnormal_anal_canal0.88442298
77MP0003123_paternal_imprinting0.88400265
78MP0002067_abnormal_sensory_capabilities0.88396611
79MP0002282_abnormal_trachea_morphology0.87728131
80MP0004233_abnormal_muscle_weight0.87383478
81MP0004197_abnormal_fetal_growth/weight/0.86963790
82MP0002152_abnormal_brain_morphology0.86725320
83MP0002557_abnormal_social/conspecific_i0.86207820
84MP0010386_abnormal_urinary_bladder0.86143036
85MP0004215_abnormal_myocardial_fiber0.83701820
86MP0000350_abnormal_cell_proliferation0.83466150
87MP0000653_abnormal_sex_gland0.83455853
88MP0001697_abnormal_embryo_size0.81683145
89MP0002752_abnormal_somatic_nervous0.80497238
90MP0002177_abnormal_outer_ear0.79523274
91MP0001485_abnormal_pinna_reflex0.79380890
92MP0005380_embryogenesis_phenotype0.79070372
93MP0001672_abnormal_embryogenesis/_devel0.79070372
94MP0006035_abnormal_mitochondrial_morpho0.78238302
95MP0000631_abnormal_neuroendocrine_gland0.77830893
96MP0002111_abnormal_tail_morphology0.77760058
97MP0000534_abnormal_ureter_morphology0.77717434
98MP0000026_abnormal_inner_ear0.77074493
99MP0002161_abnormal_fertility/fecundity0.77043342
100MP0000467_abnormal_esophagus_morphology0.76121332

Predicted human phenotypes

RankGene SetZ-score
1Volvulus (HP:0002580)3.69984184
2Abnormality of the labia minora (HP:0012880)3.47575103
3Chromosomal breakage induced by crosslinking agents (HP:0003221)3.13964522
4Hypoplastic pelvis (HP:0008839)3.05719623
5Cortical dysplasia (HP:0002539)2.95369802
6Chromsome breakage (HP:0040012)2.86909064
7Abnormal lung lobation (HP:0002101)2.62031754
8Oligodactyly (hands) (HP:0001180)2.53351200
9Split foot (HP:0001839)2.49986136
10Atonic seizures (HP:0010819)2.45892031
11Supernumerary spleens (HP:0009799)2.45055930
12Increased nuchal translucency (HP:0010880)2.29462447
13Aplasia/Hypoplasia of the uvula (HP:0010293)2.28991148
14Birth length less than 3rd percentile (HP:0003561)2.24675245
15Limb dystonia (HP:0002451)2.22569694
16Delayed gross motor development (HP:0002194)2.19742018
17Duodenal stenosis (HP:0100867)2.19252794
18Small intestinal stenosis (HP:0012848)2.19252794
19Meckel diverticulum (HP:0002245)2.19115469
20Focal motor seizures (HP:0011153)2.18591104
21Oligodactyly (HP:0012165)2.18226759
22Glioma (HP:0009733)2.14138796
23Ependymoma (HP:0002888)2.13020474
24Abnormality of chromosome stability (HP:0003220)2.12934940
25Gait imbalance (HP:0002141)2.11328592
26Congenital primary aphakia (HP:0007707)2.07970390
27Colon cancer (HP:0003003)2.07744674
28Nephrogenic diabetes insipidus (HP:0009806)2.07430335
29Cerebral hypomyelination (HP:0006808)2.06840707
30Postnatal microcephaly (HP:0005484)2.04536445
31Abnormality of the ileum (HP:0001549)2.00094774
32Medulloblastoma (HP:0002885)1.99081985
33Abnormality of the astrocytes (HP:0100707)1.98307643
34Astrocytoma (HP:0009592)1.98307643
35Median cleft lip (HP:0000161)1.94581493
36Upper limb muscle weakness (HP:0003484)1.94465319
37Microglossia (HP:0000171)1.93468512
38Increased serum pyruvate (HP:0003542)1.93442435
39Sensory axonal neuropathy (HP:0003390)1.92516874
40Medial flaring of the eyebrow (HP:0010747)1.90339235
41Abnormality of the duodenum (HP:0002246)1.88629068
42Retinal dysplasia (HP:0007973)1.88076264
43Hydroureter (HP:0000072)1.86796763
44Short tibia (HP:0005736)1.86230983
45Broad foot (HP:0001769)1.85210844
46Urethral obstruction (HP:0000796)1.84693419
47Abnormality of the labia (HP:0000058)1.81711562
48Impaired vibration sensation in the lower limbs (HP:0002166)1.81635364
49Abnormality of glycolysis (HP:0004366)1.81548866
50Abnormality of the preputium (HP:0100587)1.81176177
51Lissencephaly (HP:0001339)1.80821128
52Myokymia (HP:0002411)1.80810371
53Abnormality of the anterior horn cell (HP:0006802)1.80239688
54Degeneration of anterior horn cells (HP:0002398)1.80239688
55Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.80064803
56Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.79478220
57Degeneration of the lateral corticospinal tracts (HP:0002314)1.79478220
58Aplasia/Hypoplasia of the sacrum (HP:0008517)1.78302734
59Genital tract atresia (HP:0001827)1.77239046
60Facial cleft (HP:0002006)1.76902530
61Hypoplastic female external genitalia (HP:0012815)1.75955698
62Vaginal atresia (HP:0000148)1.75628211
63Renal dysplasia (HP:0000110)1.73865934
64Hand muscle atrophy (HP:0009130)1.71448476
65Abnormality of the carotid arteries (HP:0005344)1.70454244
66Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.70391894
67Abnormal number of incisors (HP:0011064)1.69406249
68Urinary urgency (HP:0000012)1.68790547
69Delusions (HP:0000746)1.64341443
70Shoulder girdle muscle weakness (HP:0003547)1.64238115
71Abnormality of the lower motor neuron (HP:0002366)1.62332123
72Aplasia/Hypoplasia of the tibia (HP:0005772)1.62219219
73Dyskinesia (HP:0100660)1.61201936
74Preaxial hand polydactyly (HP:0001177)1.59106723
75Sloping forehead (HP:0000340)1.58954755
76Focal seizures (HP:0007359)1.58836058
77Horseshoe kidney (HP:0000085)1.58592619
78Abnormality of the corticospinal tract (HP:0002492)1.58471705
79Absent septum pellucidum (HP:0001331)1.57800526
80Bifid tongue (HP:0010297)1.53906019
81Breast hypoplasia (HP:0003187)1.53472540
82Patellar aplasia (HP:0006443)1.53206426
83Astigmatism (HP:0000483)1.52956316
84Aplasia/Hypoplasia of the sternum (HP:0006714)1.52388254
85CNS hypomyelination (HP:0003429)1.50784425
86Atrophy/Degeneration involving motor neurons (HP:0007373)1.50767004
87Triphalangeal thumb (HP:0001199)1.49733928
88Stenosis of the external auditory canal (HP:0000402)1.49669459
89Ankle contracture (HP:0006466)1.49581438
90Specific learning disability (HP:0001328)1.49503516
91Generalized tonic-clonic seizures (HP:0002069)1.47654884
92Anophthalmia (HP:0000528)1.47471492
93Abnormality of the musculature of the pelvis (HP:0001469)1.47085928
94Abnormality of the hip-girdle musculature (HP:0001445)1.47085928
95Increased hepatocellular lipid droplets (HP:0006565)1.46967467
96Selective tooth agenesis (HP:0001592)1.45122560
97Aplasia involving forearm bones (HP:0009822)1.45108519
98Absent forearm bone (HP:0003953)1.45108519
99Aganglionic megacolon (HP:0002251)1.45030873
100Small hand (HP:0200055)1.44451727

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.41120926
2TTK3.32794185
3NEK13.11351955
4CDC72.85986688
5WEE12.50657897
6ZAK2.50630806
7BCR2.21006018
8PLK42.20096448
9CCNB12.04305240
10TRIM282.00190734
11MARK11.93094384
12BRSK21.84848020
13TSSK61.80696593
14PLK11.75279339
15CSNK1G31.75108778
16PLK31.74826927
17CSNK1G21.65093026
18BRSK11.64881379
19MAP4K21.61375534
20ERBB31.58833146
21CSNK1G11.56696354
22MAP2K71.56509429
23PLK21.50799493
24LATS11.50466879
25SRPK11.50446062
26STK161.44681947
27LIMK11.39368549
28EPHA41.38074553
29PBK1.33706350
30EIF2AK11.29681366
31WNK31.28401573
32MAP3K41.27255356
33MINK11.26053357
34PNCK1.24144181
35TESK11.23435555
36CSNK1A1L1.23429959
37BRAF1.20713878
38UHMK11.19369332
39MAPK131.19010163
40ARAF1.12313753
41MAP3K121.11219838
42CHEK21.07154235
43EIF2AK31.06043767
44AURKA1.04220999
45MKNK11.03007577
46ATR0.96215576
47CDK180.94199001
48CDK140.94006641
49PAK60.92951175
50AURKB0.89389237
51LATS20.87993134
52CDK150.87277123
53BCKDK0.87097990
54CAMK2B0.86377894
55MAPKAPK50.86136450
56MET0.85585480
57DYRK20.85401828
58STK38L0.84457759
59NUAK10.84208551
60TAF10.82789378
61MKNK20.82360512
62STK30.81842942
63BMPR1B0.81779769
64CDK11A0.81044726
65PRKCG0.79628468
66VRK20.78840127
67DYRK30.76756271
68CDK70.74837823
69MAP3K90.71931419
70CAMK2G0.69696346
71CAMK2A0.69576268
72PRKD30.68624730
73ADRBK20.68318057
74VRK10.67298632
75CASK0.65415164
76CDK190.64834678
77EIF2AK20.64711789
78ERBB40.60510487
79PIM20.59207603
80PRKCE0.56795398
81AKT20.56596610
82NEK90.55784847
83STK390.55672929
84NEK20.55212757
85ATM0.52456214
86PRKCI0.51968415
87EPHA20.51494030
88CAMK2D0.51272709
89CSNK1E0.46612111
90CDK10.46101351
91EPHB20.45360287
92MST40.44726858
93CHEK10.44248443
94MAP2K40.44231473
95RPS6KA40.42666006
96PTK20.42285550
97CDK30.38742462
98NME10.37963153
99CDK20.36009927
100RPS6KA50.34519114

Predicted pathways (KEGG)

RankGene SetZ-score
1Mismatch repair_Homo sapiens_hsa034303.48000506
2DNA replication_Homo sapiens_hsa030303.17631022
3Base excision repair_Homo sapiens_hsa034102.74720224
4Protein export_Homo sapiens_hsa030602.57605244
5Proteasome_Homo sapiens_hsa030502.44524649
6Homologous recombination_Homo sapiens_hsa034402.18671025
7Cell cycle_Homo sapiens_hsa041102.15802401
8Fanconi anemia pathway_Homo sapiens_hsa034602.14239479
9Nucleotide excision repair_Homo sapiens_hsa034202.08004437
10Non-homologous end-joining_Homo sapiens_hsa034502.07833359
11Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.98535674
12Nicotine addiction_Homo sapiens_hsa050331.84806867
13Oocyte meiosis_Homo sapiens_hsa041141.84167535
14Basal transcription factors_Homo sapiens_hsa030221.78906999
15Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.71820064
16Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.67136724
17RNA transport_Homo sapiens_hsa030131.58902052
182-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.49344180
19Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.48749116
20Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.46030142
21Cysteine and methionine metabolism_Homo sapiens_hsa002701.44029025
22Parkinsons disease_Homo sapiens_hsa050121.37878655
23Folate biosynthesis_Homo sapiens_hsa007901.36421555
24Fatty acid elongation_Homo sapiens_hsa000621.35279423
25Pyrimidine metabolism_Homo sapiens_hsa002401.33015229
26Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.31526890
27Spliceosome_Homo sapiens_hsa030401.30211913
28Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.29565737
29Steroid biosynthesis_Homo sapiens_hsa001001.28719827
30Sulfur relay system_Homo sapiens_hsa041221.25108236
31Pyruvate metabolism_Homo sapiens_hsa006201.24088906
32Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.23240885
33Oxidative phosphorylation_Homo sapiens_hsa001901.20575707
34Huntingtons disease_Homo sapiens_hsa050161.19880282
35RNA polymerase_Homo sapiens_hsa030201.19715277
36Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.17035451
37Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.16573489
38RNA degradation_Homo sapiens_hsa030181.16560732
39GABAergic synapse_Homo sapiens_hsa047271.16022566
40Vitamin B6 metabolism_Homo sapiens_hsa007501.13213620
41Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.12515049
42Biosynthesis of amino acids_Homo sapiens_hsa012301.10013771
43Synaptic vesicle cycle_Homo sapiens_hsa047211.08743000
44One carbon pool by folate_Homo sapiens_hsa006701.02537282
45mRNA surveillance pathway_Homo sapiens_hsa030151.01226577
46p53 signaling pathway_Homo sapiens_hsa041151.01199420
47Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.97787407
48Hippo signaling pathway_Homo sapiens_hsa043900.95673540
49Selenocompound metabolism_Homo sapiens_hsa004500.92529901
50Phototransduction_Homo sapiens_hsa047440.91797440
51Dopaminergic synapse_Homo sapiens_hsa047280.87550802
52Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.85897579
53Propanoate metabolism_Homo sapiens_hsa006400.82502337
54Alzheimers disease_Homo sapiens_hsa050100.79019326
55Morphine addiction_Homo sapiens_hsa050320.78863294
56Amphetamine addiction_Homo sapiens_hsa050310.78850436
57Vibrio cholerae infection_Homo sapiens_hsa051100.78744242
58Cocaine addiction_Homo sapiens_hsa050300.78387425
59Purine metabolism_Homo sapiens_hsa002300.77770376
60Circadian rhythm_Homo sapiens_hsa047100.77230138
61Cardiac muscle contraction_Homo sapiens_hsa042600.71906552
62Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.71386489
63Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.70961832
64Hedgehog signaling pathway_Homo sapiens_hsa043400.70739199
65Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.68799139
66Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.68470809
67Carbon metabolism_Homo sapiens_hsa012000.67723735
68Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.67343195
69Taste transduction_Homo sapiens_hsa047420.66145824
70Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.65329051
71Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.64138565
72TGF-beta signaling pathway_Homo sapiens_hsa043500.63102974
73Arginine and proline metabolism_Homo sapiens_hsa003300.62442841
74Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.59713806
75Butanoate metabolism_Homo sapiens_hsa006500.58930841
76Gap junction_Homo sapiens_hsa045400.58802237
77Glutathione metabolism_Homo sapiens_hsa004800.58386133
78Glutamatergic synapse_Homo sapiens_hsa047240.56080398
79Regulation of autophagy_Homo sapiens_hsa041400.53769580
80Basal cell carcinoma_Homo sapiens_hsa052170.53727937
81Circadian entrainment_Homo sapiens_hsa047130.51292051
82N-Glycan biosynthesis_Homo sapiens_hsa005100.50430726
83Axon guidance_Homo sapiens_hsa043600.49863446
84Wnt signaling pathway_Homo sapiens_hsa043100.49688510
85Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.48278438
86Fatty acid metabolism_Homo sapiens_hsa012120.46425833
87Metabolic pathways_Homo sapiens_hsa011000.45229855
88beta-Alanine metabolism_Homo sapiens_hsa004100.44485188
89Sulfur metabolism_Homo sapiens_hsa009200.44439974
90Alcoholism_Homo sapiens_hsa050340.42850455
91Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.38320981
92Phenylalanine metabolism_Homo sapiens_hsa003600.38120401
93Olfactory transduction_Homo sapiens_hsa047400.37129822
94Gastric acid secretion_Homo sapiens_hsa049710.36107682
95Cyanoamino acid metabolism_Homo sapiens_hsa004600.35861668
96Peroxisome_Homo sapiens_hsa041460.31475681
97Adherens junction_Homo sapiens_hsa045200.30785958
98Collecting duct acid secretion_Homo sapiens_hsa049660.28537766
99Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.27917078
100Melanogenesis_Homo sapiens_hsa049160.27759292

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