THADA

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is the target of 2p21 choromosomal aberrations in benign thyroid adenomas. Single nucleotide polymorphisms (SNPs) in this gene may be associated with type 2 diabetes and polycystic ovary syndrome. The encoded protein is likely involved in the death receptor pathway and apoptosis. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)6.02778861
2nuclear pore organization (GO:0006999)5.92772177
3monoubiquitinated protein deubiquitination (GO:0035520)5.51849564
4mitotic sister chromatid cohesion (GO:0007064)4.82198755
5pore complex assembly (GO:0046931)4.75849526
6pre-miRNA processing (GO:0031054)4.49578568
7cilium or flagellum-dependent cell motility (GO:0001539)4.32169496
8cellular response to ethanol (GO:0071361)4.25025854
9protein K48-linked deubiquitination (GO:0071108)4.20092479
10neural tube formation (GO:0001841)4.12720367
11hepatocyte apoptotic process (GO:0097284)4.10186077
12protein K11-linked deubiquitination (GO:0035871)4.10097883
13prenylation (GO:0097354)4.07256552
14protein prenylation (GO:0018342)4.07256552
15phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)4.03902424
16regulation of histone H3-K9 methylation (GO:0051570)3.93542405
17mitotic nuclear envelope disassembly (GO:0007077)3.88262178
18DNA unwinding involved in DNA replication (GO:0006268)3.81627542
19IMP biosynthetic process (GO:0006188)3.78132565
20positive regulation of developmental pigmentation (GO:0048087)3.77902350
21negative regulation of histone methylation (GO:0031061)3.72025372
22establishment of protein localization to Golgi (GO:0072600)3.70749731
23DNA geometric change (GO:0032392)3.68903729
24protein localization to kinetochore (GO:0034501)3.68713932
25DNA duplex unwinding (GO:0032508)3.68141870
26negative regulation of DNA repair (GO:0045738)3.61707063
27regulation of posttranscriptional gene silencing (GO:0060147)3.59867492
28regulation of gene silencing by miRNA (GO:0060964)3.59867492
29regulation of gene silencing by RNA (GO:0060966)3.59867492
30membrane disassembly (GO:0030397)3.57539348
31nuclear envelope disassembly (GO:0051081)3.57539348
32peptidyl-lysine trimethylation (GO:0018023)3.55477666
33regulation of DNA endoreduplication (GO:0032875)3.54529523
34regulation of establishment of cell polarity (GO:2000114)3.54034751
35replication fork processing (GO:0031297)3.51464923
36snRNA transcription (GO:0009301)3.49079779
37DNA replication-dependent nucleosome organization (GO:0034723)3.47432662
38DNA replication-dependent nucleosome assembly (GO:0006335)3.47432662
39positive regulation of mitotic sister chromatid separation (GO:1901970)3.47122596
40positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.47122596
41positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.47122596
42cytoplasmic mRNA processing body assembly (GO:0033962)3.45099372
43UDP-N-acetylglucosamine metabolic process (GO:0006047)3.39040243
44pericardium development (GO:0060039)3.38138962
45histone mRNA catabolic process (GO:0071044)3.35952466
46interkinetic nuclear migration (GO:0022027)3.31763479
47regulation of RNA export from nucleus (GO:0046831)3.31105159
48regulation of nuclear cell cycle DNA replication (GO:0033262)3.31057698
49RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.30725830
50mitotic chromosome condensation (GO:0007076)3.29967345
51dosage compensation (GO:0007549)3.29830261
52IMP metabolic process (GO:0046040)3.28517796
53DNA replication initiation (GO:0006270)3.23513694
54sister chromatid segregation (GO:0000819)3.22399393
55regulation of hippo signaling (GO:0035330)3.21005072
56protein K63-linked deubiquitination (GO:0070536)3.20644866
57kinetochore organization (GO:0051383)3.19671289
58histone-serine phosphorylation (GO:0035404)3.17318488
59folic acid-containing compound biosynthetic process (GO:0009396)3.14096044
60epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.12677963
61protein localization to chromosome, centromeric region (GO:0071459)3.11297840
62regulation of establishment or maintenance of cell polarity (GO:0032878)3.07157828
63peptidyl-lysine methylation (GO:0018022)3.06707565
64regulation of pigment cell differentiation (GO:0050932)3.04635184
65rRNA catabolic process (GO:0016075)3.03438962
66double-strand break repair via homologous recombination (GO:0000724)3.02731597
67regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.02688421
68positive regulation of chromosome segregation (GO:0051984)3.02225233
69regulation of spindle organization (GO:0090224)3.00566565
70mitotic recombination (GO:0006312)2.99086904
71sister chromatid cohesion (GO:0007062)2.98495664
72mitotic sister chromatid segregation (GO:0000070)2.97953407
73recombinational repair (GO:0000725)2.96218185
74signal peptide processing (GO:0006465)2.95591909
75regulation of sister chromatid cohesion (GO:0007063)2.95156861
76regulation of translational fidelity (GO:0006450)2.94558646
77DNA conformation change (GO:0071103)2.91923035
78somatic diversification of immune receptors via somatic mutation (GO:0002566)2.91643963
79somatic hypermutation of immunoglobulin genes (GO:0016446)2.91643963
80positive regulation of gamma-delta T cell activation (GO:0046645)2.91559581
81fibroblast migration (GO:0010761)2.91374396
82phospholipid translocation (GO:0045332)2.91359112
83lipid translocation (GO:0034204)2.91359112
84protein targeting to Golgi (GO:0000042)2.90313898
85meiotic chromosome segregation (GO:0045132)2.89552861
86negative regulation of DNA-dependent DNA replication (GO:2000104)2.89461861
87microtubule anchoring (GO:0034453)2.87468810
88regulation of mitotic spindle organization (GO:0060236)2.87300452
89telomere maintenance via recombination (GO:0000722)2.86972519
90mitotic metaphase plate congression (GO:0007080)2.86679697
91retrograde transport, vesicle recycling within Golgi (GO:0000301)2.86337729
92protein K6-linked ubiquitination (GO:0085020)2.84308173
93histone H3-K9 methylation (GO:0051567)2.84116190
94N-terminal protein amino acid acetylation (GO:0006474)2.84013374
95regulation of gene silencing (GO:0060968)2.83737626
96reciprocal meiotic recombination (GO:0007131)2.82922124
97reciprocal DNA recombination (GO:0035825)2.82922124
98metaphase plate congression (GO:0051310)2.82622341
99histone H2A monoubiquitination (GO:0035518)2.81737464
100DNA strand elongation involved in DNA replication (GO:0006271)2.80602135
101telomere maintenance (GO:0000723)2.80459662
102regulation of centriole replication (GO:0046599)2.80201597
103telomere maintenance via semi-conservative replication (GO:0032201)2.80194181
104positive regulation of granulocyte differentiation (GO:0030854)2.79917155
105Golgi to endosome transport (GO:0006895)2.79790277
106mRNA cleavage (GO:0006379)2.79597640
107negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.79409988
108negative regulation of translation, ncRNA-mediated (GO:0040033)2.79409988
109regulation of translation, ncRNA-mediated (GO:0045974)2.79409988
110interferon-gamma production (GO:0032609)2.75781756
111regulation of helicase activity (GO:0051095)2.75301999
112maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.74862552
113telomere organization (GO:0032200)2.73929907
114histone lysine methylation (GO:0034968)2.72788219
115ncRNA catabolic process (GO:0034661)2.71886537
116DNA strand elongation (GO:0022616)2.71264925
117mismatch repair (GO:0006298)2.71229451
118histone H3-K4 methylation (GO:0051568)2.70744735
119negative T cell selection (GO:0043383)2.70358010
120definitive hemopoiesis (GO:0060216)2.70190291
121iron ion import (GO:0097286)2.70024747
122chromatin assembly (GO:0031497)2.69764175
123determination of adult lifespan (GO:0008340)2.68471583
124positive thymic T cell selection (GO:0045059)2.68150690
125histone H3-K9 modification (GO:0061647)2.67900634
126chromatin assembly or disassembly (GO:0006333)2.67857972
127gene silencing by RNA (GO:0031047)2.67802376
128regulation of centrosome cycle (GO:0046605)2.66756024
129nuclear envelope organization (GO:0006998)2.66575658
130translesion synthesis (GO:0019985)2.66467137
131mRNA transport (GO:0051028)2.66329771
132regulation of telomere maintenance via telomerase (GO:0032210)2.65926221
133NLS-bearing protein import into nucleus (GO:0006607)2.65205429
134attachment of spindle microtubules to kinetochore (GO:0008608)2.63845875
135replicative senescence (GO:0090399)2.63187786
136telomere maintenance via telomere lengthening (GO:0010833)2.61657844
137histone H3-K36 demethylation (GO:0070544)2.61329399
138regulation of mitotic metaphase/anaphase transition (GO:0030071)2.61326336
139protein targeting to lysosome (GO:0006622)2.59632787
140establishment of protein localization to vacuole (GO:0072666)2.59632787
141protein targeting to vacuole (GO:0006623)2.59632787
142regulation of centrosome duplication (GO:0010824)2.59411200
143DNA replication-independent nucleosome assembly (GO:0006336)2.58477888
144DNA replication-independent nucleosome organization (GO:0034724)2.58477888
145negative thymic T cell selection (GO:0045060)2.58376332
146positive regulation of DNA-templated transcription, initiation (GO:2000144)2.57264407
147histone H3-K4 trimethylation (GO:0080182)2.56489375
148kinetochore assembly (GO:0051382)2.55415448
149snRNA processing (GO:0016180)2.55008856
150regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.54229087
151chromatin remodeling at centromere (GO:0031055)2.53887012
152establishment of chromosome localization (GO:0051303)2.53833932
153histone H4-K12 acetylation (GO:0043983)2.52632587
154cilium movement (GO:0003341)2.51971219
155L-fucose catabolic process (GO:0042355)2.51930988
156fucose catabolic process (GO:0019317)2.51930988
157L-fucose metabolic process (GO:0042354)2.51930988
158regulation of nucleobase-containing compound transport (GO:0032239)2.51761290
159genitalia morphogenesis (GO:0035112)2.50774972
160positive regulation of protein import into nucleus, translocation (GO:0033160)2.50497324
161regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.47271011
162regulation of mitotic spindle checkpoint (GO:1903504)2.47271011
163regulation of B cell receptor signaling pathway (GO:0050855)2.47116107
164regulation of protein polyubiquitination (GO:1902914)2.44996773
165nucleus localization (GO:0051647)2.44979054
166protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:0042787)2.43288035
167intra-S DNA damage checkpoint (GO:0031573)2.43054881
168positive regulation of transcription from RNA polymerase III promoter (GO:0045945)2.41346848
169photoreceptor cell maintenance (GO:0045494)2.40752600

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human4.76854116
2E2F4_17652178_ChIP-ChIP_JURKAT_Human4.16586451
3EGR1_19374776_ChIP-ChIP_THP-1_Human3.87126145
4FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.17226609
5FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.12421928
6* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.96574047
7CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.91788893
8FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.88009741
9MYC_18555785_ChIP-Seq_MESCs_Mouse2.70549747
10SALL1_21062744_ChIP-ChIP_HESCs_Human2.64602541
11MYC_22102868_ChIP-Seq_BL_Human2.49933655
12GATA1_22025678_ChIP-Seq_K562_Human2.35107383
13E2F1_21310950_ChIP-Seq_MCF-7_Human2.33058539
14POU3F2_20337985_ChIP-ChIP_501MEL_Human2.29587112
15PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.16600787
16STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.15263935
17ZNF274_21170338_ChIP-Seq_K562_Hela2.09811049
18FLI1_27457419_Chip-Seq_LIVER_Mouse2.08758420
19SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.07372994
20AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human2.02407588
21MYC_19079543_ChIP-ChIP_MESCs_Mouse2.02163234
22E2F7_22180533_ChIP-Seq_HELA_Human11.0810869
23SMAD_19615063_ChIP-ChIP_OVARY_Human1.99561459
24NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.92289412
25MYC_19030024_ChIP-ChIP_MESCs_Mouse1.89408225
26GBX2_23144817_ChIP-Seq_PC3_Human1.88809238
27IGF1R_20145208_ChIP-Seq_DFB_Human1.86819594
28FUS_26573619_Chip-Seq_HEK293_Human1.83904220
29TP63_19390658_ChIP-ChIP_HaCaT_Human1.81213337
30STAT3_23295773_ChIP-Seq_U87_Human1.79937787
31ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.76544759
32MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.76064512
33NELFA_20434984_ChIP-Seq_ESCs_Mouse1.73868266
34PCGF2_27294783_Chip-Seq_ESCs_Mouse1.70362983
35NOTCH1_21737748_ChIP-Seq_TLL_Human1.70112238
36YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.68626269
37TP53_16413492_ChIP-PET_HCT116_Human1.68055105
38AR_21909140_ChIP-Seq_LNCAP_Human1.65987828
39TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.65585885
40ZFP57_27257070_Chip-Seq_ESCs_Mouse1.65355950
41* EWS_26573619_Chip-Seq_HEK293_Human1.63815042
42SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.63168104
43ER_23166858_ChIP-Seq_MCF-7_Human1.61715483
44TAF15_26573619_Chip-Seq_HEK293_Human1.59516230
45CIITA_25753668_ChIP-Seq_RAJI_Human1.58375501
46IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.53248586
47VDR_22108803_ChIP-Seq_LS180_Human1.53190277
48SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.53091767
49GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.52142675
50MYCN_18555785_ChIP-Seq_MESCs_Mouse1.48718480
51IRF8_22096565_ChIP-ChIP_GC-B_Human1.48022311
52ESR1_20079471_ChIP-ChIP_T-47D_Human1.47954254
53STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.47746482
54PCGF2_27294783_Chip-Seq_NPCs_Mouse1.47115805
55TCF4_23295773_ChIP-Seq_U87_Human1.46920778
56VDR_23849224_ChIP-Seq_CD4+_Human1.46616242
57EZH2_27294783_Chip-Seq_NPCs_Mouse1.45611630
58SMAD4_21799915_ChIP-Seq_A2780_Human1.45210509
59KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.44139809
60KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.44139809
61KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.44139809
62MYB_26560356_Chip-Seq_TH1_Human1.43806377
63FOXP3_21729870_ChIP-Seq_TREG_Human1.43605164
64MYB_26560356_Chip-Seq_TH2_Human1.42948524
65BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.42286013
66GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.42161249
67ELK1_19687146_ChIP-ChIP_HELA_Human1.41839943
68* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.41731423
69SUZ12_27294783_Chip-Seq_NPCs_Mouse1.41562029
70EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.41244186
71MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.40925151
72* AHR_22903824_ChIP-Seq_MCF-7_Human1.40146358
73SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.38835103
74NANOG_18555785_ChIP-Seq_MESCs_Mouse1.37949953
75CBP_20019798_ChIP-Seq_JUKART_Human1.37872209
76IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.37872209
77NFE2_27457419_Chip-Seq_LIVER_Mouse1.37440049
78CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.37420207
79* FOXM1_26456572_ChIP-Seq_MCF-7_Human1.34958337
80POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.33594931
81MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.31768923
82FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.30782124
83* P300_19829295_ChIP-Seq_ESCs_Human1.30291772
84MYC_18358816_ChIP-ChIP_MESCs_Mouse1.29180435
85SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.27687050
86KDM5A_27292631_Chip-Seq_BREAST_Human1.27352580
87MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.26090187
88ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.25885713
89HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.23994584
90BRD4_25478319_ChIP-Seq_HGPS_Human1.23690964
91PIAS1_25552417_ChIP-Seq_VCAP_Human1.23628064
92CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.21858674
93PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.21714628
94PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.21529020
95* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.20774612
96* ARNT_22903824_ChIP-Seq_MCF-7_Human1.20319610
97AR_21572438_ChIP-Seq_LNCaP_Human1.19969661
98RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.19708999
99EST1_17652178_ChIP-ChIP_JURKAT_Human1.19569997
100HOXB4_20404135_ChIP-ChIP_EML_Mouse1.19452988
101* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.18809142
102* CTNNB1_20460455_ChIP-Seq_HCT116_Human1.18246717
103DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.16965275
104VDR_21846776_ChIP-Seq_THP-1_Human1.14291411
105* XRN2_22483619_ChIP-Seq_HELA_Human1.14041446
106MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.13983716
107POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.12284599
108UTX_26944678_Chip-Seq_JUKART_Human1.12064711
109* EGR1_23403033_ChIP-Seq_LIVER_Mouse1.11991968
110PADI4_21655091_ChIP-ChIP_MCF-7_Human1.11512370
111TFEB_21752829_ChIP-Seq_HELA_Human1.11371909
112CRX_20693478_ChIP-Seq_RETINA_Mouse1.10804042
113TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.10510106
114UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.09230713
115FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.09200241
116CDX2_22108803_ChIP-Seq_LS180_Human1.08279610
117E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.08248560
118* FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.08036136
119RUNX_20019798_ChIP-Seq_JUKART_Human1.07927158
120GATA3_26560356_Chip-Seq_TH2_Human1.07704022
121* NR3C1_21868756_ChIP-Seq_MCF10A_Human1.07647245
122OCT4_21477851_ChIP-Seq_ESCs_Mouse1.06909833
123BCAT_22108803_ChIP-Seq_LS180_Human1.06075420
124FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.05994888
125POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.04849023
126TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04849023
127SOX2_18555785_ChIP-Seq_MESCs_Mouse1.04275678
128E2F1_18555785_Chip-Seq_ESCs_Mouse1.04054805
129ELF1_17652178_ChIP-ChIP_JURKAT_Human1.03960861
130* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.02406956
131NANOG_18555785_Chip-Seq_ESCs_Mouse1.02370012
132STAT4_19710469_ChIP-ChIP_TH1__Mouse1.01229761
133FLI1_21867929_ChIP-Seq_TH2_Mouse1.01049619
134TCF7_22412390_ChIP-Seq_EML_Mouse1.00886842
135MAF_26560356_Chip-Seq_TH1_Human1.00823182
136ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.00799288
137TCF4_22108803_ChIP-Seq_LS180_Human1.00081010
138STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.00038614
139FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.99789205
140PKCTHETA_26484144_Chip-Seq_BREAST_Human0.99421018
141FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.99350463
142ERG_20887958_ChIP-Seq_HPC-7_Mouse0.99301312
143SPI1_23547873_ChIP-Seq_NB4_Human0.98530996
144IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.98439990
145SMAD3_21741376_ChIP-Seq_EPCs_Human0.97834759
146SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.97665728
147HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.97399662
148CTBP2_25329375_ChIP-Seq_LNCAP_Human0.97351921
149SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.95798820
150P300_18555785_Chip-Seq_ESCs_Mouse0.95434929
151TP63_23658742_ChIP-Seq_EP156T_Human0.95163093
152* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.95129015
153SCL_19346495_ChIP-Seq_HPC-7_Human0.94918974
154MYB_21317192_ChIP-Seq_ERMYB_Mouse0.94896004
155STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.93946647
156TTF2_22483619_ChIP-Seq_HELA_Human0.93025071
157TCF3_18692474_ChIP-Seq_MESCs_Mouse0.92589629
158SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.91362563
159* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.91276664
160BRD4_27068464_Chip-Seq_AML-cells_Mouse0.88756151
161* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.87187730
162KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.86232358
163RUNX1_22412390_ChIP-Seq_EML_Mouse0.84728637
164* GABP_19822575_ChIP-Seq_HepG2_Human0.83409557
165PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.82310991
166E2F1_18555785_ChIP-Seq_MESCs_Mouse0.81924114
167E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.81617402
168NANOG_21062744_ChIP-ChIP_HESCs_Human0.80142004
169ZFX_18555785_ChIP-Seq_MESCs_Mouse0.79845680
170RBPJ_22232070_ChIP-Seq_NCS_Mouse0.79256654
171RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.79210112
172POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.78912642
173KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.78601343
174STAT3_1855785_ChIP-Seq_MESCs_Mouse0.77583111

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication3.86758812
2MP0010094_abnormal_chromosome_stability3.71404570
3MP0003111_abnormal_nucleus_morphology3.22002395
4MP0002396_abnormal_hematopoietic_system2.92760001
5MP0003077_abnormal_cell_cycle2.92630947
6MP0003693_abnormal_embryo_hatching2.86957243
7MP0010352_gastrointestinal_tract_polyps2.78754951
8MP0000569_abnormal_digit_pigmentation2.63773669
9MP0008058_abnormal_DNA_repair2.60872149
10MP0010678_abnormal_skin_adnexa2.53699791
11MP0000427_abnormal_hair_cycle2.46684598
12MP0003763_abnormal_thymus_physiology2.45392279
13MP0004957_abnormal_blastocyst_morpholog2.44285797
14MP0003950_abnormal_plasma_membrane2.43948577
15MP0010307_abnormal_tumor_latency2.28574097
16MP0008007_abnormal_cellular_replicative2.28194945
17MP0008877_abnormal_DNA_methylation2.20304875
18MP0005076_abnormal_cell_differentiation1.94190357
19MP0002166_altered_tumor_susceptibility1.94095115
20MP0001661_extended_life_span1.91585642
21MP0003941_abnormal_skin_development1.88543888
22MP0003195_calcinosis1.88132426
23MP0003890_abnormal_embryonic-extraembry1.86147429
24MP0003786_premature_aging1.85428146
25MP0003646_muscle_fatigue1.84080556
26MP0000350_abnormal_cell_proliferation1.81334036
27MP0004808_abnormal_hematopoietic_stem1.76774218
28MP0002006_tumorigenesis1.71006400
29MP0006054_spinal_hemorrhage1.67879495
30MP0001293_anophthalmia1.66583487
31MP0001730_embryonic_growth_arrest1.65153624
32MP0000703_abnormal_thymus_morphology1.62828589
33MP0002168_other_aberrant_phenotype1.61573944
34MP0004381_abnormal_hair_follicle1.60462533
35MP0009697_abnormal_copulation1.59665249
36MP0005310_abnormal_salivary_gland1.56429972
37MP0005408_hypopigmentation1.56219276
38MP0005380_embryogenesis_phenotype1.54060427
39MP0001672_abnormal_embryogenesis/_devel1.54060427
40MP0002398_abnormal_bone_marrow1.51806198
41MP0001800_abnormal_humoral_immune1.45677976
42MP0003121_genomic_imprinting1.42499709
43MP0003984_embryonic_growth_retardation1.42374166
44MP0002088_abnormal_embryonic_growth/wei1.39084085
45MP0001835_abnormal_antigen_presentation1.37874438
46MP0004197_abnormal_fetal_growth/weight/1.37698959
47MP0002086_abnormal_extraembryonic_tissu1.37496975
48MP0002009_preneoplasia1.34995015
49MP0002084_abnormal_developmental_patter1.33960976
50MP0003300_gastrointestinal_ulcer1.33278546
51MP0008932_abnormal_embryonic_tissue1.30441316
52MP0002138_abnormal_hepatobiliary_system1.29275689
53MP0000490_abnormal_crypts_of1.28535885
54MP0002085_abnormal_embryonic_tissue1.26118397
55MP0005174_abnormal_tail_pigmentation1.25147997
56MP0005671_abnormal_response_to1.24560236
57MP0002722_abnormal_immune_system1.23308810
58MP0005395_other_phenotype1.22262507
59MP0001697_abnormal_embryo_size1.21601668
60MP0000689_abnormal_spleen_morphology1.18927123
61MP0000371_diluted_coat_color1.18738147
62MP0003252_abnormal_bile_duct1.17966900
63MP0000685_abnormal_immune_system1.17448745
64MP0008961_abnormal_basal_metabolism1.17279581
65MP0001545_abnormal_hematopoietic_system1.16193869
66MP0005397_hematopoietic_system_phenotyp1.16193869
67MP0002019_abnormal_tumor_incidence1.15172825
68MP0003566_abnormal_cell_adhesion1.14466922
69MP0000372_irregular_coat_pigmentation1.12690105
70MP0000716_abnormal_immune_system1.10654187
71MP0003705_abnormal_hypodermis_morpholog1.10531566
72MP0001873_stomach_inflammation1.09472708
73MP0002080_prenatal_lethality1.08481899
74MP0003123_paternal_imprinting1.07590776
75MP0002420_abnormal_adaptive_immunity1.07589594
76MP0002877_abnormal_melanocyte_morpholog1.06679628
77MP0005647_abnormal_sex_gland1.06507099
78MP0003787_abnormal_imprinting1.06234803
79MP0002452_abnormal_antigen_presenting1.06199270
80MP0003656_abnormal_erythrocyte_physiolo1.06018818
81MP0005387_immune_system_phenotype1.05690269
82MP0001790_abnormal_immune_system1.05690269
83MP0009333_abnormal_splenocyte_physiolog1.05588437
84MP0001819_abnormal_immune_cell1.05499402
85MP0002075_abnormal_coat/hair_pigmentati1.04518127
86MP0002405_respiratory_system_inflammati1.04071067
87MP0009703_decreased_birth_body1.03035064
88MP0000358_abnormal_cell_content/1.02966415
89MP0004264_abnormal_extraembryonic_tissu1.02723280
90MP0000313_abnormal_cell_death1.01718644
91MP0005023_abnormal_wound_healing1.00761180
92MP0002429_abnormal_blood_cell1.00712125
93MP0005075_abnormal_melanosome_morpholog1.00515984
94MP0003937_abnormal_limbs/digits/tail_de1.00179913
95MP0002723_abnormal_immune_serum0.99727508
96MP0002095_abnormal_skin_pigmentation0.94172702
97MP0009278_abnormal_bone_marrow0.93727769
98MP0006292_abnormal_olfactory_placode0.91243570
99MP0001915_intracranial_hemorrhage0.90251897
100MP0002092_abnormal_eye_morphology0.90162476
101MP0000566_synostosis0.90012056
102MP0003045_fibrosis0.89933598
103MP0010234_abnormal_vibrissa_follicle0.89436731
104MP0003718_maternal_effect0.88024463
105MP0003878_abnormal_ear_physiology0.87545123
106MP0005377_hearing/vestibular/ear_phenot0.87545123
107MP0002210_abnormal_sex_determination0.84281476
108MP0001324_abnormal_eye_pigmentation0.83467858
109MP0005266_abnormal_metabolism0.82872802
110MP0009672_abnormal_birth_weight0.82665525
111MP0000432_abnormal_head_morphology0.82264054
112MP0000383_abnormal_hair_follicle0.81864026
113MP0005253_abnormal_eye_physiology0.81661477
114MP0000015_abnormal_ear_pigmentation0.80394539
115MP0001186_pigmentation_phenotype0.80182795
116MP0005220_abnormal_exocrine_pancreas0.80071679
117MP0005171_absent_coat_pigmentation0.79353301
118MP0008995_early_reproductive_senescence0.79292691
119MP0002697_abnormal_eye_size0.78624797
120MP0005621_abnormal_cell_physiology0.76661970
121MP0002925_abnormal_cardiovascular_devel0.76496044
122MP0003567_abnormal_fetal_cardiomyocyte0.75803619
123MP0002928_abnormal_bile_duct0.75577419
124MP0005551_abnormal_eye_electrophysiolog0.75488357
125MP0000428_abnormal_craniofacial_morphol0.74740895
126MP0001145_abnormal_male_reproductive0.73322951
127MP0003935_abnormal_craniofacial_develop0.71811992
128MP0001286_abnormal_eye_development0.71308076
129MP0001929_abnormal_gametogenesis0.71292481
130MP0003943_abnormal_hepatobiliary_system0.70879860
131MP0010155_abnormal_intestine_physiology0.70740454
132MP0009115_abnormal_fat_cell0.70141713
133MP0004043_abnormal_pH_regulation0.68216499
134MP0000377_abnormal_hair_follicle0.66905784
135MP0002102_abnormal_ear_morphology0.65358916
136MP0006035_abnormal_mitochondrial_morpho0.64972030
137MP0000647_abnormal_sebaceous_gland0.64715519
138MP0005083_abnormal_biliary_tract0.63422177
139MP0000538_abnormal_urinary_bladder0.63178546
140MP0003868_abnormal_feces_composition0.62004048
141MP0001191_abnormal_skin_condition0.61242115
142MP0005384_cellular_phenotype0.60477089

Predicted human phenotypes

RankGene SetZ-score
1Chromsome breakage (HP:0040012)4.01491520
2Abnormality of the fingertips (HP:0001211)3.85783339
3Chromosomal breakage induced by crosslinking agents (HP:0003221)3.65094935
4Chronic hepatic failure (HP:0100626)3.57223102
5Pancreatic cysts (HP:0001737)3.38786273
6Abnormality of the renal cortex (HP:0011035)3.15233431
7Volvulus (HP:0002580)3.13034388
8Ectopic kidney (HP:0000086)3.03267739
9Thyroiditis (HP:0100646)3.02151148
10Pancreatic fibrosis (HP:0100732)2.89355583
11Gaze-evoked nystagmus (HP:0000640)2.86055059
12Tubular atrophy (HP:0000092)2.85814096
13Abnormality of chromosome stability (HP:0003220)2.83463206
14Ependymoma (HP:0002888)2.80209417
15Medulloblastoma (HP:0002885)2.79316802
16Abnormality of midbrain morphology (HP:0002418)2.78554494
17Molar tooth sign on MRI (HP:0002419)2.78554494
18Tubulointerstitial nephritis (HP:0001970)2.77065559
19Hyperventilation (HP:0002883)2.72191330
20Selective tooth agenesis (HP:0001592)2.70023716
21Prominent nose (HP:0000448)2.64406302
22T lymphocytopenia (HP:0005403)2.63860411
23Genetic anticipation (HP:0003743)2.59007285
24Colon cancer (HP:0003003)2.57856413
25Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.57783841
26Short 4th metacarpal (HP:0010044)2.57783841
27Abnormality of the renal medulla (HP:0100957)2.57449617
28True hermaphroditism (HP:0010459)2.56745220
29Long eyelashes (HP:0000527)2.55859895
30Lip pit (HP:0100267)2.54562103
31Abnormality of T cell number (HP:0011839)2.52048022
32Fair hair (HP:0002286)2.50100417
33Nephronophthisis (HP:0000090)2.46549654
34Urethral obstruction (HP:0000796)2.40966849
35Attenuation of retinal blood vessels (HP:0007843)2.39332024
36Cerebellar dysplasia (HP:0007033)2.38285068
37Skull defect (HP:0001362)2.36947164
3811 pairs of ribs (HP:0000878)2.33437577
39Protruding tongue (HP:0010808)2.32305688
40Basal cell carcinoma (HP:0002671)2.31156116
41Abnormality of the labia minora (HP:0012880)2.31100833
42Abnormality of the astrocytes (HP:0100707)2.28986085
43Astrocytoma (HP:0009592)2.28986085
44Abnormality of the renal collecting system (HP:0004742)2.28184275
45Cystic liver disease (HP:0006706)2.26145228
46Myelodysplasia (HP:0002863)2.24443426
47Aplasia/Hypoplasia of the uvula (HP:0010293)2.23670117
48Deviation of the thumb (HP:0009603)2.23089690
49Renal cortical cysts (HP:0000803)2.21751197
50Aplasia/Hypoplasia of the sternum (HP:0006714)2.21580325
51Impulsivity (HP:0100710)2.21525495
52Rhabdomyosarcoma (HP:0002859)2.18684835
53Proximal placement of thumb (HP:0009623)2.17846228
54Glucose intolerance (HP:0000833)2.17175524
55Widely spaced teeth (HP:0000687)2.17153186
56Bile duct proliferation (HP:0001408)2.17138759
57Abnormal biliary tract physiology (HP:0012439)2.17138759
58Intestinal fistula (HP:0100819)2.16247006
59Absent/shortened dynein arms (HP:0200106)2.15551409
60Dynein arm defect of respiratory motile cilia (HP:0012255)2.15551409
61Acute myeloid leukemia (HP:0004808)2.14791948
62Agnosia (HP:0010524)2.14744263
63Glioma (HP:0009733)2.14570018
64Abnormal glucose tolerance (HP:0001952)2.14338115
65Neoplasm of the oral cavity (HP:0100649)2.13865008
66Generalized hypopigmentation of hair (HP:0011358)2.13016620
67Abnormal number of incisors (HP:0011064)2.12869319
68Aplasia/Hypoplasia of the tongue (HP:0010295)2.12231584
69Abnormality of DNA repair (HP:0003254)2.12038682
70Rhinitis (HP:0012384)2.11386448
71Trigonocephaly (HP:0000243)2.09631533
72Birth length less than 3rd percentile (HP:0003561)2.09318433
73Abnormality of the preputium (HP:0100587)2.08746340
74Bronchiectasis (HP:0002110)2.07326349
75Deep philtrum (HP:0002002)2.06814920
76Meckel diverticulum (HP:0002245)2.06314506
77Duplicated collecting system (HP:0000081)2.06275678
78Intestinal atresia (HP:0011100)2.05852988
79Clubbing of toes (HP:0100760)2.05446961
80Postaxial foot polydactyly (HP:0001830)2.04731250
81Increased nuchal translucency (HP:0010880)2.04223437
82Anal stenosis (HP:0002025)2.03337583
83Hypoplasia of the thymus (HP:0000778)2.03328036
84IgM deficiency (HP:0002850)2.02876228
85Neoplasm of the adrenal cortex (HP:0100641)2.02821694
86Recurrent viral infections (HP:0004429)2.02513148
87Abnormality of the nasal septum (HP:0000419)2.00710845
88Truncal obesity (HP:0001956)1.97876883
89Abnormality of the ileum (HP:0001549)1.97096606
90Long clavicles (HP:0000890)1.96858616
91Autoimmune hemolytic anemia (HP:0001890)1.96025329
92Central scotoma (HP:0000603)1.95830006
93Highly arched eyebrow (HP:0002553)1.94829829
94Abnormal ciliary motility (HP:0012262)1.93583297
95Hyperkalemia (HP:0002153)1.93024442
96Amaurosis fugax (HP:0100576)1.91301783
97IgA deficiency (HP:0002720)1.90653842
98Cafe-au-lait spot (HP:0000957)1.90281634
99Nephroblastoma (Wilms tumor) (HP:0002667)1.89777781
100Aplasia/Hypoplasia of the tibia (HP:0005772)1.89742523
101Abnormality of T cells (HP:0002843)1.88994489
102Hematochezia (HP:0002573)1.88548077
103Furrowed tongue (HP:0000221)1.88141507
104Sloping forehead (HP:0000340)1.87490084
105Tubulointerstitial abnormality (HP:0001969)1.87264194
106Fibular hypoplasia (HP:0003038)1.87070325
107Abnormal delayed hypersensitivity skin test (HP:0002963)1.85546732
108Short chin (HP:0000331)1.85277707
109Lymphoma (HP:0002665)1.85219571
110Optic nerve coloboma (HP:0000588)1.84432828
111Sandal gap (HP:0001852)1.84422267
112Absent frontal sinuses (HP:0002688)1.84301729
113Biliary tract neoplasm (HP:0100574)1.82208374
114Abnormality of the carotid arteries (HP:0005344)1.82090562
115Hypoplastic labia majora (HP:0000059)1.82041723
116Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.79738744
117Neonatal hypoglycemia (HP:0001998)1.78789551
118Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.78617290
119Panhypogammaglobulinemia (HP:0003139)1.77830341
120Premature graying of hair (HP:0002216)1.77169346
121Reticulocytopenia (HP:0001896)1.76647314
122Congenital hepatic fibrosis (HP:0002612)1.74801024
123Abnormal lung lobation (HP:0002101)1.74731116
124Missing ribs (HP:0000921)1.74693731
125Embryonal renal neoplasm (HP:0011794)1.74311043
126Low anterior hairline (HP:0000294)1.74113607
127Neoplasm of striated muscle (HP:0009728)1.73768814
128Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)1.73741496
129Dislocated radial head (HP:0003083)1.73143217
130Tented upper lip vermilion (HP:0010804)1.72580929
131Keratoconus (HP:0000563)1.71643100
132Increased corneal curvature (HP:0100692)1.71643100
133Absent thumb (HP:0009777)1.70516808
134Poikiloderma (HP:0001029)1.70305993
135Enlarged kidneys (HP:0000105)1.70137604
136Limited elbow extension (HP:0001377)1.70053687
137Recurrent fungal infections (HP:0002841)1.69298045
138Curly hair (HP:0002212)1.68911330
139Type II lissencephaly (HP:0007260)1.68411667
140Broad thumb (HP:0011304)1.68113422
141Submucous cleft hard palate (HP:0000176)1.68038225
142Dandy-Walker malformation (HP:0001305)1.67607354
143Blepharitis (HP:0000498)1.67086332
144Severe combined immunodeficiency (HP:0004430)1.66882402
145Duodenal stenosis (HP:0100867)1.65661255
146Small intestinal stenosis (HP:0012848)1.65661255
147Skin tags (HP:0010609)1.65654637
148Abnormality of B cell number (HP:0010975)1.65323482
149Supernumerary ribs (HP:0005815)1.64344108
150Colitis (HP:0002583)1.64173619
151Stomach cancer (HP:0012126)1.64079258
152Abnormal pancreas size (HP:0012094)1.63912112
153Absent radius (HP:0003974)1.62513266
154Leukopenia (HP:0001882)1.61567608
155Neoplasm of the respiratory system (HP:0100606)1.61263049
156Papillary thyroid carcinoma (HP:0002895)1.60749081
157Abnormality of the incisor (HP:0000676)1.60396496
158Abnormality of the labia majora (HP:0012881)1.60183017
159Narrow palate (HP:0000189)1.59974924
160Chronic diarrhea (HP:0002028)1.59861551
161Abnormality of cells of the lymphoid lineage (HP:0012140)1.59319216
162Cellular immunodeficiency (HP:0005374)1.58557462
163Lymphopenia (HP:0001888)1.58345938
164Absent eyebrow (HP:0002223)1.58103080
165Recurrent cutaneous fungal infections (HP:0011370)1.57770105
166Chronic mucocutaneous candidiasis (HP:0002728)1.57770105
167Underdeveloped nasal alae (HP:0000430)1.57653290
168Heterotopia (HP:0002282)1.57495533

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK125.01649080
2CDC73.73839942
3BMPR1B2.70054827
4BRD42.44743159
5EEF2K2.33193051
6MAP4K12.28123999
7TXK2.19641708
8STK102.13081365
9NEK22.07486781
10ATR2.00077485
11TTK1.99439263
12NUAK11.95348430
13ZAK1.94500751
14WEE11.79142227
15SRPK11.78790474
16TSSK61.76608407
17EIF2AK31.71706832
18CAMK1D1.71102115
19PASK1.64304809
20MAP3K101.61229331
21JAK31.54560777
22RPS6KB21.51966711
23EPHA21.48399257
24CDK41.48323123
25LATS11.48125874
26CDK71.40676282
27CHEK21.39711681
28CHEK11.39643470
29PNCK1.39482421
30FLT31.37674468
31STK41.35323263
32MKNK21.34045996
33ATM1.33069560
34PIK3CG1.33011560
35AKT31.32135777
36ALK1.31245373
37MKNK11.30803210
38MAP3K141.28767883
39IRAK11.28365536
40ITK1.25989107
41TLK11.25201963
42FGFR31.22733896
43PIM11.16211223
44AURKB1.15425970
45MELK1.15037662
46TEC1.12365526
47PLK11.09099170
48MTOR1.07925945
49SIK21.06279016
50TTN1.03164869
51PBK1.03086258
52CDK61.01695592
53BRSK21.01682130
54STK31.01579537
55CHUK1.00290068
56ZAP700.99300663
57PLK30.98582694
58MET0.98269950
59STK390.96291325
60CLK10.96031642
61TYK20.95548256
62ADRBK20.94630047
63CAMKK20.94401119
64STK38L0.92408903
65MST1R0.91299554
66PRKAA20.90560832
67RPS6KA40.90297094
68CDK20.89581398
69NLK0.89196776
70SIK10.88598857
71TAOK30.88162863
72PTK2B0.87750647
73EIF2AK10.87208571
74FRK0.87000851
75WNK10.86920434
76MAP3K80.86248937
77VRK10.86079355
78MAP3K70.85450638
79SIK30.84831185
80MARK30.84384997
81CAMK1G0.83528420
82FGFR20.82974871
83ACVR1B0.81540307
84CDK90.81417687
85PKN20.80241883
86MAPK110.76793645
87KIT0.73932262
88BTK0.73449183
89NEK60.73289621
90FER0.72439907
91TGFBR10.72278814
92PLK40.72222631
93MST40.72079752
94TGFBR20.70793793
95CSF1R0.70473824
96LCK0.70278364
97FGFR40.69524812
98MAP3K130.69309057
99YES10.68838595
100CDK10.68095594
101JAK10.67913006
102CSNK1D0.67394969
103ADRBK10.67317264
104HCK0.63023187
105BUB10.61810094
106SCYL20.60952306
107BLK0.60039071
108PRKDC0.59901683
109BMPR20.59546746
110RPS6KB10.59005834
111CSK0.58979758
112IKBKB0.58546949
113MAP3K40.56468169
114MAPK140.54690919
115NEK90.52505286
116RPS6KA50.52143430
117FGFR10.51304543
118OXSR10.50794556
119PDGFRB0.50487198
120WNK40.50142734
121INSRR0.49405854
122EPHA30.49337380
123PDK20.47998939
124ERBB30.47779829
125PRKAA10.46190541
126IKBKE0.45883943
127GRK60.45052521
128MAPK10.45010715
129GRK10.44300839
130SGK20.44017156
131TRPM70.43312107
132CSNK2A20.43248078
133STK240.42887966
134PRKCQ0.42043626
135MAPKAPK30.41852463
136EIF2AK20.41272004
137SGK30.41181814
138AKT10.40417772
139WNK30.40183980
140PAK30.39363513

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.34313268
2Mismatch repair_Homo sapiens_hsa034303.17855921
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.97467939
4One carbon pool by folate_Homo sapiens_hsa006702.73237344
5Homologous recombination_Homo sapiens_hsa034402.57009990
6RNA transport_Homo sapiens_hsa030132.41829591
7Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.38688353
8Fanconi anemia pathway_Homo sapiens_hsa034602.37977009
9Non-homologous end-joining_Homo sapiens_hsa034502.34102342
10Base excision repair_Homo sapiens_hsa034102.32171955
11Cell cycle_Homo sapiens_hsa041102.30549163
12Spliceosome_Homo sapiens_hsa030402.17647485
13Primary immunodeficiency_Homo sapiens_hsa053402.11807547
14ABC transporters_Homo sapiens_hsa020102.07616219
15Nucleotide excision repair_Homo sapiens_hsa034201.99336458
16mRNA surveillance pathway_Homo sapiens_hsa030151.89314900
17Systemic lupus erythematosus_Homo sapiens_hsa053221.80069019
18RNA degradation_Homo sapiens_hsa030181.77457287
19Antigen processing and presentation_Homo sapiens_hsa046121.75457773
20NF-kappa B signaling pathway_Homo sapiens_hsa040641.64983288
21Dorso-ventral axis formation_Homo sapiens_hsa043201.63953516
22Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.58885059
23Herpes simplex infection_Homo sapiens_hsa051681.58558271
24Viral carcinogenesis_Homo sapiens_hsa052031.47242077
25p53 signaling pathway_Homo sapiens_hsa041151.44456116
26Lysine degradation_Homo sapiens_hsa003101.44447812
27Measles_Homo sapiens_hsa051621.42275921
28Transcriptional misregulation in cancer_Homo sapiens_hsa052021.36079009
29MicroRNAs in cancer_Homo sapiens_hsa052061.35411927
30Basal transcription factors_Homo sapiens_hsa030221.32758127
31T cell receptor signaling pathway_Homo sapiens_hsa046601.32103133
32HTLV-I infection_Homo sapiens_hsa051661.30496481
33Nitrogen metabolism_Homo sapiens_hsa009101.28936656
34RNA polymerase_Homo sapiens_hsa030201.20687602
35Circadian rhythm_Homo sapiens_hsa047101.18621595
36Small cell lung cancer_Homo sapiens_hsa052221.13775664
37Epstein-Barr virus infection_Homo sapiens_hsa051691.12207011
38Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.09041031
39Pyrimidine metabolism_Homo sapiens_hsa002401.07680537
40Viral myocarditis_Homo sapiens_hsa054161.04180178
41Hematopoietic cell lineage_Homo sapiens_hsa046401.03172084
42Adherens junction_Homo sapiens_hsa045201.03161180
43Intestinal immune network for IgA production_Homo sapiens_hsa046721.01343435
44Sphingolipid metabolism_Homo sapiens_hsa006001.00441186
45Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.99331289
46Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.99018110
47Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.97415922
48B cell receptor signaling pathway_Homo sapiens_hsa046620.97284508
49Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.94341824
50Chronic myeloid leukemia_Homo sapiens_hsa052200.93210688
51Influenza A_Homo sapiens_hsa051640.92037638
52Hepatitis B_Homo sapiens_hsa051610.91872600
53Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.89399903
54Colorectal cancer_Homo sapiens_hsa052100.89322814
55Notch signaling pathway_Homo sapiens_hsa043300.88302620
56Primary bile acid biosynthesis_Homo sapiens_hsa001200.86406976
57NOD-like receptor signaling pathway_Homo sapiens_hsa046210.85902640
58Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.85838695
59Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.84151242
60Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.81984404
61Ether lipid metabolism_Homo sapiens_hsa005650.81953048
62Jak-STAT signaling pathway_Homo sapiens_hsa046300.80430776
63Acute myeloid leukemia_Homo sapiens_hsa052210.79964880
64Linoleic acid metabolism_Homo sapiens_hsa005910.79879831
65Prostate cancer_Homo sapiens_hsa052150.79366318
66Graft-versus-host disease_Homo sapiens_hsa053320.78290303
67Toxoplasmosis_Homo sapiens_hsa051450.78124725
68Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.77985935
69mTOR signaling pathway_Homo sapiens_hsa041500.77938096
70Osteoclast differentiation_Homo sapiens_hsa043800.77141531
71Leishmaniasis_Homo sapiens_hsa051400.76824938
72RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.76642087
73alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.75699035
74Apoptosis_Homo sapiens_hsa042100.74627560
75Phototransduction_Homo sapiens_hsa047440.74593975
76Insulin resistance_Homo sapiens_hsa049310.74101959
77Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.73736505
78Prolactin signaling pathway_Homo sapiens_hsa049170.73645358
79Pancreatic cancer_Homo sapiens_hsa052120.72072650
80Allograft rejection_Homo sapiens_hsa053300.71811561
81Propanoate metabolism_Homo sapiens_hsa006400.71151283
82TGF-beta signaling pathway_Homo sapiens_hsa043500.69809647
83Tryptophan metabolism_Homo sapiens_hsa003800.69696370
84Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.69325787
85Platelet activation_Homo sapiens_hsa046110.67093147
86Basal cell carcinoma_Homo sapiens_hsa052170.66502596
87Steroid hormone biosynthesis_Homo sapiens_hsa001400.66475290
88Selenocompound metabolism_Homo sapiens_hsa004500.66015524
89Non-small cell lung cancer_Homo sapiens_hsa052230.64568494
90Leukocyte transendothelial migration_Homo sapiens_hsa046700.64147943
91Thyroid hormone signaling pathway_Homo sapiens_hsa049190.63839022
92Legionellosis_Homo sapiens_hsa051340.63251842
93Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.62128509
94FoxO signaling pathway_Homo sapiens_hsa040680.61867947
95Butanoate metabolism_Homo sapiens_hsa006500.61782173
96Toll-like receptor signaling pathway_Homo sapiens_hsa046200.61678605
97Pathways in cancer_Homo sapiens_hsa052000.61544092
98Fatty acid biosynthesis_Homo sapiens_hsa000610.60619341
99Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.59631691
100Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.58776893
101Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.57541239
102Thyroid cancer_Homo sapiens_hsa052160.55133936
103Alcoholism_Homo sapiens_hsa050340.54976308
104Purine metabolism_Homo sapiens_hsa002300.54188424
105Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.54035864
106Autoimmune thyroid disease_Homo sapiens_hsa053200.53994922
107Olfactory transduction_Homo sapiens_hsa047400.53232001
108TNF signaling pathway_Homo sapiens_hsa046680.53012976
109Proteoglycans in cancer_Homo sapiens_hsa052050.52919734
110Glycerolipid metabolism_Homo sapiens_hsa005610.50370157
111Longevity regulating pathway - mammal_Homo sapiens_hsa042110.49904560
112Hippo signaling pathway_Homo sapiens_hsa043900.49571265
113Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.49094766
114Regulation of actin cytoskeleton_Homo sapiens_hsa048100.48315934
115Choline metabolism in cancer_Homo sapiens_hsa052310.48145380
116Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.47939358
117Endometrial cancer_Homo sapiens_hsa052130.47689394
118Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.47484580
119Inositol phosphate metabolism_Homo sapiens_hsa005620.46813707
120Wnt signaling pathway_Homo sapiens_hsa043100.46540339
121Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.46384067
122Ribosome_Homo sapiens_hsa030100.44279031
123Glycerophospholipid metabolism_Homo sapiens_hsa005640.43920848
124AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.43626579
125Shigellosis_Homo sapiens_hsa051310.43474314
126Sphingolipid signaling pathway_Homo sapiens_hsa040710.42867310
127Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.41579745
128Phosphatidylinositol signaling system_Homo sapiens_hsa040700.41129426
129Hepatitis C_Homo sapiens_hsa051600.40789828
130N-Glycan biosynthesis_Homo sapiens_hsa005100.37710967
131HIF-1 signaling pathway_Homo sapiens_hsa040660.37569964
132Melanoma_Homo sapiens_hsa052180.37537839
133PI3K-Akt signaling pathway_Homo sapiens_hsa041510.37302524
134Central carbon metabolism in cancer_Homo sapiens_hsa052300.37228180
135Neurotrophin signaling pathway_Homo sapiens_hsa047220.36580607
136Type I diabetes mellitus_Homo sapiens_hsa049400.34574585

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