TGS1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of protein homooligomerization (GO:0032462)9.93766035
2protein localization to peroxisome (GO:0072662)8.72411136
3protein targeting to peroxisome (GO:0006625)8.72411136
4establishment of protein localization to peroxisome (GO:0072663)8.72411136
5histone H4-K12 acetylation (GO:0043983)8.57235918
6lipopolysaccharide biosynthetic process (GO:0009103)8.56081806
7peroxisomal transport (GO:0043574)8.11463998
8lipopolysaccharide metabolic process (GO:0008653)7.51121531
9negative regulation of glycogen biosynthetic process (GO:0045719)7.01449458
10regulation of isotype switching to IgG isotypes (GO:0048302)6.86080762
11nucleotide transport (GO:0006862)6.84680394
12rRNA catabolic process (GO:0016075)6.69400341
13protein-cofactor linkage (GO:0018065)6.62502299
14positive regulation of isotype switching (GO:0045830)5.98303613
15DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla5.96791793
16peroxisome organization (GO:0007031)5.82711583
17regulation of telomere maintenance via telomerase (GO:0032210)5.73763892
18antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.62494999
19DNA damage response, signal transduction resulting in transcription (GO:0042772)5.57108262
20negative regulation of glycogen metabolic process (GO:0070874)5.51894984
21intracellular protein transmembrane import (GO:0044743)5.50777815
22microtubule anchoring (GO:0034453)5.47033872
23antigen processing and presentation via MHC class Ib (GO:0002475)5.32545150
24positive regulation of DNA recombination (GO:0045911)5.25437396
25microglial cell activation (GO:0001774)5.10622514
26regulation of protein oligomerization (GO:0032459)4.89033309
27extracellular regulation of signal transduction (GO:1900115)4.82587814
28extracellular negative regulation of signal transduction (GO:1900116)4.82587814
29regulation of energy homeostasis (GO:2000505)4.78338852
30protein localization to kinetochore (GO:0034501)4.78128326
31negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.75816236
32negative regulation of cell killing (GO:0031342)4.75816236
33adaptation of signaling pathway (GO:0023058)4.68399301
34macrophage chemotaxis (GO:0048246)4.50403442
35macrophage activation involved in immune response (GO:0002281)4.49347242
36negative regulation of telomere maintenance (GO:0032205)4.38015608
37intracellular protein transmembrane transport (GO:0065002)4.33145924
38positive regulation of mast cell activation involved in immune response (GO:0033008)4.33035503
39positive regulation of mast cell degranulation (GO:0043306)4.33035503
40CENP-A containing nucleosome assembly (GO:0034080)4.30071422
41keratan sulfate biosynthetic process (GO:0018146)4.29965114
42positive regulation of mast cell activation (GO:0033005)4.29257849
43kinetochore organization (GO:0051383)4.19765104
44histone H4-K5 acetylation (GO:0043981)4.18230701
45histone H4-K8 acetylation (GO:0043982)4.18230701
46antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.15775367
47chromatin remodeling at centromere (GO:0031055)4.09387299
48protein localization to chromosome, centromeric region (GO:0071459)4.07546938
49positive regulation of T cell mediated cytotoxicity (GO:0001916)4.00873732
50DNA replication initiation (GO:0006270)3.94643239
51membrane docking (GO:0022406)3.94379638
52negative regulation of telomerase activity (GO:0051974)3.88309112
53platelet dense granule organization (GO:0060155)3.81428855
54lysine metabolic process (GO:0006553)3.81068184
55lysine catabolic process (GO:0006554)3.81068184
56DNA replication-independent nucleosome assembly (GO:0006336)3.78327494
57DNA replication-independent nucleosome organization (GO:0034724)3.78327494
58positive regulation of interleukin-17 production (GO:0032740)3.77568626
59mitotic metaphase plate congression (GO:0007080)3.77439258
60DNA unwinding involved in DNA replication (GO:0006268)3.75656139
61DNA strand elongation involved in DNA replication (GO:0006271)3.71889400
62meiotic chromosome segregation (GO:0045132)3.69548528
63ncRNA catabolic process (GO:0034661)3.67197609
64kinetochore assembly (GO:0051382)3.66484722
65metaphase plate congression (GO:0051310)3.61194079
66ribosome assembly (GO:0042255)3.59080627
67DNA strand elongation (GO:0022616)3.58286985
68positive regulation of immunoglobulin mediated immune response (GO:0002891)3.56753738
69positive regulation of B cell mediated immunity (GO:0002714)3.56753738
70DNA replication checkpoint (GO:0000076)3.55899564
71mitotic sister chromatid cohesion (GO:0007064)3.54791977
72DNA ligation (GO:0006266)3.54570152
73regulation of monocyte differentiation (GO:0045655)3.53580465
74regulation of isotype switching (GO:0045191)3.51828787
75cilium or flagellum-dependent cell motility (GO:0001539)3.51495514
76protein transmembrane transport (GO:0071806)3.49859385
77telomere maintenance via semi-conservative replication (GO:0032201)3.49446541
78telomere maintenance via recombination (GO:0000722)3.48452828
79ribosomal small subunit assembly (GO:0000028)3.48349938
80mitotic recombination (GO:0006312)3.46745943
81thrombin receptor signaling pathway (GO:0070493)3.44195523
82pseudouridine synthesis (GO:0001522)3.39131112
83histone exchange (GO:0043486)3.39117041
84antigen processing and presentation of endogenous antigen (GO:0019883)3.39042631
85positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)3.31087304
86keratan sulfate metabolic process (GO:0042339)3.30929150
87establishment of chromosome localization (GO:0051303)3.30483762
88mitotic chromosome condensation (GO:0007076)3.27776088
89DNA topological change (GO:0006265)3.24926648
90ribosomal small subunit biogenesis (GO:0042274)3.22907882
91regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.21141366
92regulation of T cell mediated cytotoxicity (GO:0001914)3.20990752
93maturation of SSU-rRNA (GO:0030490)3.17364029
94IMP biosynthetic process (GO:0006188)3.17143560
95regulation of nuclear cell cycle DNA replication (GO:0033262)3.17143006
96nucleotide-excision repair, DNA gap filling (GO:0006297)3.15550273
97histone mRNA catabolic process (GO:0071044)3.13548986
98activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO3.13309104
99histone H4-K16 acetylation (GO:0043984)3.11852650
100triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.11646768
101positive regulation of immunoglobulin production (GO:0002639)3.09728349
102positive regulation of myeloid leukocyte mediated immunity (GO:0002888)3.09728267
103regulation of extracellular matrix disassembly (GO:0010715)3.08592894
104telomere maintenance via telomere lengthening (GO:0010833)3.08408147
105mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.07897778
106nuclear pore complex assembly (GO:0051292)3.07075586
107nuclear pore organization (GO:0006999)3.04503593
108positive regulation of natural killer cell mediated immunity (GO:0002717)3.02384120
109regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)3.01360115
110regulation of double-strand break repair via homologous recombination (GO:0010569)3.00246947
111attachment of spindle microtubules to kinetochore (GO:0008608)2.96002395
112establishment of integrated proviral latency (GO:0075713)2.95896638
113glycerophospholipid catabolic process (GO:0046475)2.95664928
114* spliceosomal snRNP assembly (GO:0000387)2.94771627
115organelle transport along microtubule (GO:0072384)2.93956597
116spindle checkpoint (GO:0031577)2.92692225
117nucleobase biosynthetic process (GO:0046112)2.92274661
118IMP metabolic process (GO:0046040)2.89251362
119positive regulation of chromosome segregation (GO:0051984)2.87962677
120positive regulation of leukocyte degranulation (GO:0043302)2.86567945
121negative regulation of glucose import (GO:0046325)2.85335526
122histone mRNA metabolic process (GO:0008334)2.84992399
123translational termination (GO:0006415)2.84526453
124mismatch repair (GO:0006298)2.83796619
125intra-S DNA damage checkpoint (GO:0031573)2.83607755
126sleep (GO:0030431)2.83545214
127viral transcription (GO:0019083)2.83227093
128positive regulation vascular endothelial growth factor production (GO:0010575)2.83075151
129transcription elongation from RNA polymerase III promoter (GO:0006385)2.82147410
130termination of RNA polymerase III transcription (GO:0006386)2.82147410
131negative regulation of DNA-dependent DNA replication (GO:2000104)2.80558884
132purine nucleobase biosynthetic process (GO:0009113)2.80126869
133exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.80073354
134viral mRNA export from host cell nucleus (GO:0046784)2.79374018
135regulation of helicase activity (GO:0051095)2.77431456
136positive regulation of leukocyte mediated immunity (GO:0002705)2.77322065
137positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.75309882
138positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.75309882
139positive regulation of mitotic sister chromatid separation (GO:1901970)2.75309882
140maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.75052020
141regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.74446576
142protein localization to chromosome (GO:0034502)2.72010927
143mitotic nuclear envelope disassembly (GO:0007077)2.71837805
144sulfation (GO:0051923)2.71602646
145rRNA processing (GO:0006364)2.71076170
146negative regulation of mast cell activation (GO:0033004)2.71058454
147mitotic spindle checkpoint (GO:0071174)2.70412924
148carbohydrate derivative transport (GO:1901264)2.69777490
149formation of translation preinitiation complex (GO:0001731)2.69725705
150deoxyribonucleoside diphosphate metabolic process (GO:0009186)2.69056892
151nucleoside diphosphate phosphorylation (GO:0006165)2.68525103
152nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.68400542
153ATP-dependent chromatin remodeling (GO:0043044)2.68207550
154* ribonucleoprotein complex biogenesis (GO:0022613)2.67626756
155telomere maintenance (GO:0000723)2.67526503
156regulation of mitotic spindle checkpoint (GO:1903504)2.66631794
157regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.66631794
158DNA synthesis involved in DNA repair (GO:0000731)2.66629682
159DNA deamination (GO:0045006)2.66370297
160regulation of protein kinase A signaling (GO:0010738)2.65983343
161telomere organization (GO:0032200)2.65522379
162cellular protein complex disassembly (GO:0043624)2.64354771
163ADP metabolic process (GO:0046031)2.63489623
164pore complex assembly (GO:0046931)2.60304143
165histone H2A acetylation (GO:0043968)2.59514668
166positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:003572.59000930
167rRNA metabolic process (GO:0016072)2.58847930
168histone H3-K9 methylation (GO:0051567)2.58826159
169ribosome biogenesis (GO:0042254)2.58666578
170cellular zinc ion homeostasis (GO:0006882)2.58121488
171DNA catabolic process, exonucleolytic (GO:0000738)2.57623041
172mitotic G2/M transition checkpoint (GO:0044818)2.57537022
173regulation of centrosome cycle (GO:0046605)2.57306670
174positive regulation of lymphocyte mediated immunity (GO:0002708)2.57102898
175spliceosomal complex assembly (GO:0000245)2.56366409
176CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.55562221
177T-helper cell differentiation (GO:0042093)2.55562221
178positive regulation of leukocyte mediated cytotoxicity (GO:0001912)2.55285437
179chromatin assembly or disassembly (GO:0006333)2.53389828
180transcription-coupled nucleotide-excision repair (GO:0006283)2.53196464
181RNA splicing, via transesterification reactions (GO:0000375)2.52370390
182sister chromatid segregation (GO:0000819)2.50675429
183DNA-templated transcription, termination (GO:0006353)2.50586962
184transcription from RNA polymerase III promoter (GO:0006383)2.50227568
185mRNA splicing, via spliceosome (GO:0000398)2.49385451
186RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.49385451
187regulation of mitotic metaphase/anaphase transition (GO:0030071)2.48973821
188somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.48740072
189somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.48740072
190isotype switching (GO:0045190)2.48740072
191regulation of T cell chemotaxis (GO:0010819)2.48495876
192positive regulation of T cell chemotaxis (GO:0010820)2.48495876
193somatic recombination of immunoglobulin gene segments (GO:0016447)2.48104593
194chromosome segregation (GO:0007059)2.47219935
195maturation of 5.8S rRNA (GO:0000460)17.8366030
196negative regulation of protein oligomerization (GO:0032460)13.9969089
197nucleotide transmembrane transport (GO:1901679)13.4799836
198protein import into peroxisome matrix (GO:0016558)13.0719069
199T-helper 1 type immune response (GO:0042088)10.0257154

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.20721583
2STAT6_21828071_ChIP-Seq_BEAS2B_Human7.88384977
3CHD7_19251738_ChIP-ChIP_MESCs_Mouse5.63844881
4E2F4_17652178_ChIP-ChIP_JURKAT_Human4.28117064
5FOXM1_23109430_ChIP-Seq_U2OS_Human3.77747885
6MYC_18555785_ChIP-Seq_MESCs_Mouse3.63983001
7HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.51928591
8E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.38613623
9KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.22786920
10FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.14171107
11EST1_17652178_ChIP-ChIP_JURKAT_Human3.06008851
12IKZF1_21737484_ChIP-ChIP_HCT116_Human3.00225657
13HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.00107571
14TDRD3_21172665_ChIP-Seq_MCF-7_Human2.93980116
15SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.93787093
16GABP_17652178_ChIP-ChIP_JURKAT_Human2.79383703
17VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human2.66616864
18MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.48335313
19* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.39924217
20TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.38160695
21CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.30924803
22CREB1_15753290_ChIP-ChIP_HEK293T_Human2.30385548
23BP1_19119308_ChIP-ChIP_Hs578T_Human2.29524939
24ELK1_19687146_ChIP-ChIP_HELA_Human2.27269796
25ETS1_20019798_ChIP-Seq_JURKAT_Human2.27170364
26IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.25113209
27VDR_23849224_ChIP-Seq_CD4+_Human2.23215355
28* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.22869389
29SREBP1_19666523_ChIP-Seq_LIVER_Mouse2.19714400
30MYC_18358816_ChIP-ChIP_MESCs_Mouse2.18021150
31MYC_19079543_ChIP-ChIP_MESCs_Mouse2.14674542
32HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.07570206
33ELF1_17652178_ChIP-ChIP_JURKAT_Human2.05964497
34AR_21909140_ChIP-Seq_LNCAP_Human2.05634529
35YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.05008916
36EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.03404243
37EGR1_19374776_ChIP-ChIP_THP-1_Human2.02999334
38E2F1_21310950_ChIP-Seq_MCF-7_Human2.02479674
39JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.99499940
40XRN2_22483619_ChIP-Seq_HELA_Human1.94202263
41FOXP3_21729870_ChIP-Seq_TREG_Human1.93620633
42NELFA_20434984_ChIP-Seq_ESCs_Mouse1.90449229
43* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.89344670
44* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.86537361
45MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.86313936
46CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.86148105
47PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.83314549
48HOXB4_20404135_ChIP-ChIP_EML_Mouse1.83278711
49TTF2_22483619_ChIP-Seq_HELA_Human1.82940796
50IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.77811567
51TP63_19390658_ChIP-ChIP_HaCaT_Human1.74867110
52ZNF274_21170338_ChIP-Seq_K562_Hela1.70060756
53SALL1_21062744_ChIP-ChIP_HESCs_Human1.69458402
54NOTCH1_21737748_ChIP-Seq_TLL_Human1.69180728
55EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.65057355
56DCP1A_22483619_ChIP-Seq_HELA_Human1.62416378
57MYCN_18555785_ChIP-Seq_MESCs_Mouse1.61999842
58IRF8_21731497_ChIP-ChIP_J774_Mouse1.54557882
59PADI4_21655091_ChIP-ChIP_MCF-7_Human1.52974160
60TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.51875234
61EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.48997860
62STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.47384765
63CIITA_25753668_ChIP-Seq_RAJI_Human1.46850185
64SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.46284743
65EWS_26573619_Chip-Seq_HEK293_Human1.44072908
66FUS_26573619_Chip-Seq_HEK293_Human1.44041940
67THAP11_20581084_ChIP-Seq_MESCs_Mouse1.43836298
68* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.41194796
69GABP_19822575_ChIP-Seq_HepG2_Human1.36044721
70MYC_18940864_ChIP-ChIP_HL60_Human1.33662044
71* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.33064502
72SRF_21415370_ChIP-Seq_HL-1_Mouse1.31506206
73EGR1_23403033_ChIP-Seq_LIVER_Mouse1.29013718
74ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.28535740
75RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human1.27551835
76POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.24284835
77ERG_20887958_ChIP-Seq_HPC-7_Mouse1.24098657
78RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.23423125
79ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.22517833
80FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.20466333
81* SPI1_23547873_ChIP-Seq_NB4_Human1.17879571
82* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.15111418
83NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.14364875
84MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.14183150
85BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.13645943
86PU_27001747_Chip-Seq_BMDM_Mouse1.13353676
87* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.11212391
88CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.10911945
89NANOG_16153702_ChIP-ChIP_HESCs_Human1.10702688
90MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.09174679
91SCL_19346495_ChIP-Seq_HPC-7_Human1.08947398
92KDM5A_27292631_Chip-Seq_BREAST_Human1.07323836
93YY1_21170310_ChIP-Seq_MESCs_Mouse1.06232159
94ETV2_25802403_ChIP-Seq_MESCs_Mouse1.06084831
95TAF2_19829295_ChIP-Seq_ESCs_Human1.05361629
96ZFX_18555785_ChIP-Seq_MESCs_Mouse1.05127880
97* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.04038527
98E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.02892766
99PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.02612964
100NANOG_18555785_ChIP-Seq_MESCs_Mouse1.02453967
101FOXA1_25329375_ChIP-Seq_VCAP_Human0.99252715
102FOXA1_27270436_Chip-Seq_PROSTATE_Human0.99252715
103CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.99209115
104RBPJ_22232070_ChIP-Seq_NCS_Mouse0.99067778
105POU3F2_20337985_ChIP-ChIP_501MEL_Human0.97974475
106ELF1_20517297_ChIP-Seq_JURKAT_Human0.97011328
107* CTBP1_25329375_ChIP-Seq_LNCAP_Human0.96661811
108ELK1_22589737_ChIP-Seq_MCF10A_Human0.95980894
109POU5F1_16153702_ChIP-ChIP_HESCs_Human0.93963026
110AUTS2_25519132_ChIP-Seq_293T-REX_Human0.93700448
111POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.91170708
112SOX2_18555785_ChIP-Seq_MESCs_Mouse0.90810147
113E2F1_20622854_ChIP-Seq_HELA_Human0.89783278
114CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.87625259
115RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.87068428
116GATA3_21878914_ChIP-Seq_MCF-7_Human0.87044403
117MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.85893366
118SALL4_22934838_ChIP-ChIP_CD34+_Human0.85000674
119IGF1R_20145208_ChIP-Seq_DFB_Human0.84540275
120BMI1_23680149_ChIP-Seq_NPCS_Mouse0.84015342
121MYC_19915707_ChIP-ChIP_AK7_Human0.83875541
122YY1_22570637_ChIP-Seq_MALME-3M_Human0.83804228
123TP63_17297297_ChIP-ChIP_HaCaT_Human0.81549795
124SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.80764699
125SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.80362603
126VDR_22108803_ChIP-Seq_LS180_Human0.79581393
127SOX2_16153702_ChIP-ChIP_HESCs_Human0.78216032
128TFEB_21752829_ChIP-Seq_HELA_Human0.77809366
129FLI1_27457419_Chip-Seq_LIVER_Mouse0.77582101
130STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.77276066
131PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.77220181
132RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.76000080
133TRIM28_21343339_ChIP-Seq_HEK293_Human0.75816835
134NANOG_18692474_ChIP-Seq_MEFs_Mouse0.74423042
135STAT4_19710469_ChIP-ChIP_TH1__Mouse0.73677000
136POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.73656852
137IRF1_19129219_ChIP-ChIP_H3396_Human0.73052430
138CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.72879339
139CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.72840447
140MYB_21317192_ChIP-Seq_ERMYB_Mouse0.71055967
141OCT4_18692474_ChIP-Seq_MEFs_Mouse0.70668522
142KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.70568866
143RUNX_20019798_ChIP-Seq_JUKART_Human0.69909514
144PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.68018960
145TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.67959616
146FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.67703735
147SOX2_21211035_ChIP-Seq_LN229_Human0.67222967
148ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.66876911
149CRX_20693478_ChIP-Seq_RETINA_Mouse0.66702112
150TCF4_18268006_ChIP-ChIP_LS174T_Human0.66391137
151CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.66143845
152POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.65618083
153GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.65448514
154KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.64887308
155BCAT_22108803_ChIP-Seq_LS180_Human0.64514051
156IRF8_22096565_ChIP-ChIP_GC-B_Human0.64320798
157* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.64235596
158UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.63401645

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006082_CNS_inflammation9.70538971
2MP0008057_abnormal_DNA_replication5.39153330
3MP0001873_stomach_inflammation4.76304162
4MP0001348_abnormal_lacrimal_gland4.54332421
5MP0001346_abnormal_lacrimal_gland4.47695363
6MP0002132_abnormal_respiratory_system4.40998867
7MP0003300_gastrointestinal_ulcer3.81968320
8MP0010094_abnormal_chromosome_stability3.79140858
9MP0006292_abnormal_olfactory_placode3.56442984
10MP0003690_abnormal_glial_cell3.50647062
11MP0002876_abnormal_thyroid_physiology3.37915913
12MP0003077_abnormal_cell_cycle3.19707379
13MP0003693_abnormal_embryo_hatching3.11062520
14MP0003111_abnormal_nucleus_morphology3.05548583
15MP0008058_abnormal_DNA_repair3.01507695
16MP0002396_abnormal_hematopoietic_system2.71692484
17MP0004957_abnormal_blastocyst_morpholog2.70702405
18MP0008007_abnormal_cellular_replicative2.68783681
19MP0008877_abnormal_DNA_methylation2.47643528
20MP0000569_abnormal_digit_pigmentation2.35998526
21MP0003121_genomic_imprinting2.16521125
22MP0003123_paternal_imprinting2.11578276
23MP0002837_dystrophic_cardiac_calcinosis2.10854159
24MP0009697_abnormal_copulation2.10290297
25MP0008932_abnormal_embryonic_tissue2.06087975
26MP0002254_reproductive_system_inflammat11.4118743
27MP0001835_abnormal_antigen_presentation1.90442111
28MP0005174_abnormal_tail_pigmentation1.90407793
29MP0003950_abnormal_plasma_membrane1.88070703
30MP0005647_abnormal_sex_gland1.63784151
31MP0002938_white_spotting1.61020237
32MP0003787_abnormal_imprinting1.59504272
33MP0004808_abnormal_hematopoietic_stem1.51880123
34MP0009333_abnormal_splenocyte_physiolog1.47532505
35MP0005671_abnormal_response_to1.47159732
36MP0001293_anophthalmia1.46941121
37MP0003763_abnormal_thymus_physiology1.46177559
38MP0002148_abnormal_hypersensitivity_rea1.45942502
39MP0000350_abnormal_cell_proliferation1.42831844
40MP0009379_abnormal_foot_pigmentation1.41018508
41MP0002398_abnormal_bone_marrow1.39648192
42MP0000613_abnormal_salivary_gland1.35394460
43MP0000490_abnormal_crypts_of1.32485235
44MP0002102_abnormal_ear_morphology1.32471651
45MP0001800_abnormal_humoral_immune1.32238141
46MP0003567_abnormal_fetal_cardiomyocyte1.31933842
47MP0003122_maternal_imprinting1.31646211
48MP0001851_eye_inflammation1.31550132
49MP0001730_embryonic_growth_arrest1.31508295
50MP0001915_intracranial_hemorrhage1.30085912
51MP0005000_abnormal_immune_tolerance1.28687463
52MP0002006_tumorigenesis1.27922585
53MP0001984_abnormal_olfaction1.25607437
54MP0000685_abnormal_immune_system1.25055787
55MP0000015_abnormal_ear_pigmentation1.20284714
56MP0005197_abnormal_uvea_morphology1.18532394
57MP0001663_abnormal_digestive_system1.17386515
58MP0003890_abnormal_embryonic-extraembry1.16755343
59MP0002452_abnormal_antigen_presenting1.16658564
60MP0009785_altered_susceptibility_to1.15437680
61MP0001188_hyperpigmentation1.15268685
62MP0000920_abnormal_myelination1.14863559
63MP0002095_abnormal_skin_pigmentation1.13558521
64MP0002420_abnormal_adaptive_immunity1.12794752
65MP0003786_premature_aging1.12396206
66MP0000313_abnormal_cell_death1.12053662
67MP0002166_altered_tumor_susceptibility1.12025156
68MP0001819_abnormal_immune_cell1.10748508
69MP0005595_abnormal_vascular_smooth1.10131698
70MP0005380_embryogenesis_phenotype1.09284429
71MP0001672_abnormal_embryogenesis/_devel1.09284429
72MP0002723_abnormal_immune_serum1.07831892
73MP0001697_abnormal_embryo_size1.07429802
74MP0000716_abnormal_immune_system1.07403823
75MP0001919_abnormal_reproductive_system1.05937158
76MP0000689_abnormal_spleen_morphology1.04684539
77MP0000566_synostosis1.00857865
78MP0000703_abnormal_thymus_morphology1.00659466
79MP0005075_abnormal_melanosome_morpholog0.99706154
80MP0005409_darkened_coat_color0.99490391
81MP0003984_embryonic_growth_retardation0.99441548
82MP0002722_abnormal_immune_system0.99087596
83MP0003436_decreased_susceptibility_to0.98958073
84MP0002277_abnormal_respiratory_mucosa0.98929786
85MP0002429_abnormal_blood_cell0.98480869
86MP0005025_abnormal_response_to0.97648895
87MP0004883_abnormal_blood_vessel0.97648638
88MP0003136_yellow_coat_color0.96906340
89MP0003938_abnormal_ear_development0.96673667
90MP0002088_abnormal_embryonic_growth/wei0.94760214
91MP0002085_abnormal_embryonic_tissue0.92396478
92MP0003937_abnormal_limbs/digits/tail_de0.91854453
93MP0001529_abnormal_vocalization0.91219080
94MP0009046_muscle_twitch0.90065119
95MP0005166_decreased_susceptibility_to0.88600111
96MP0002419_abnormal_innate_immunity0.87506755
97MP0003315_abnormal_perineum_morphology0.87212996
98MP0002405_respiratory_system_inflammati0.86773586
99MP0003718_maternal_effect0.85656899
100MP0002080_prenatal_lethality0.85159060
101MP0001286_abnormal_eye_development0.84458790
102MP0002084_abnormal_developmental_patter0.83988670
103MP0000383_abnormal_hair_follicle0.83249292
104MP0002019_abnormal_tumor_incidence0.82384275
105MP0001853_heart_inflammation0.82237676
106MP0005381_digestive/alimentary_phenotyp0.82059312
107MP0010155_abnormal_intestine_physiology0.80939383
108MP0005076_abnormal_cell_differentiation0.80879762
109MP0001119_abnormal_female_reproductive0.79877377
110MP0002751_abnormal_autonomic_nervous0.78622113
111MP0002210_abnormal_sex_determination0.77236392
112MP0010307_abnormal_tumor_latency0.76024756
113MP0005387_immune_system_phenotype0.75576716
114MP0001790_abnormal_immune_system0.75576716
115MP0005164_abnormal_response_to0.75190515
116MP0005389_reproductive_system_phenotype0.74957275
117MP0001545_abnormal_hematopoietic_system0.74895603
118MP0005397_hematopoietic_system_phenotyp0.74895603
119MP0002163_abnormal_gland_morphology0.74345115
120MP0002638_abnormal_pupillary_reflex0.74232990
121MP0000631_abnormal_neuroendocrine_gland0.73496489
122MP0003943_abnormal_hepatobiliary_system0.73423804
123MP0005310_abnormal_salivary_gland0.72366055
124MP0005023_abnormal_wound_healing0.71272720
125MP0004197_abnormal_fetal_growth/weight/0.70375959
126MP0000858_altered_metastatic_potential0.70096397
127MP0003183_abnormal_peptide_metabolism0.68602573
128MP0002086_abnormal_extraembryonic_tissu0.68550416
129MP0005645_abnormal_hypothalamus_physiol0.68363323
130MP0002693_abnormal_pancreas_physiology0.68117776
131MP0004134_abnormal_chest_morphology0.66295103
132MP0000470_abnormal_stomach_morphology0.64836424
133MP0003448_altered_tumor_morphology0.63533248
134MP0005448_abnormal_energy_balance0.63333447
135MP0000465_gastrointestinal_hemorrhage0.62958325
136MP0010352_gastrointestinal_tract_polyps0.62883512
137MP0009053_abnormal_anal_canal0.62245776
138MP0003699_abnormal_female_reproductive0.58936899
139MP0009763_increased_sensitivity_to0.57437572
140MP0009765_abnormal_xenobiotic_induced0.55947302
141MP0003724_increased_susceptibility_to0.54393290
142MP0000477_abnormal_intestine_morphology0.41293319
143MP0000639_abnormal_adrenal_gland0.41066408
144MP0005376_homeostasis/metabolism_phenot0.38187238
145MP0001944_abnormal_pancreas_morphology0.35529343
146MP0003698_abnormal_male_reproductive0.33885262
147MP0008770_decreased_survivor_rate0.33602332
148MP0004885_abnormal_endolymph0.33257878
149MP0008873_increased_physiological_sensi0.32797381
150MP0002998_abnormal_bone_remodeling0.32401344
151MP0005379_endocrine/exocrine_gland_phen0.31923037
152MP0008469_abnormal_protein_level0.28533406
153MP0001845_abnormal_inflammatory_respons0.28473089
154MP0005266_abnormal_metabolism0.27272998
155MP0000653_abnormal_sex_gland0.24501981
156MP0002160_abnormal_reproductive_system0.22182290
157MP0005167_abnormal_blood-brain_barrier0.22155479
158MP0002229_neurodegeneration0.21495029
159MP0005584_abnormal_enzyme/coenzyme_acti0.20922773
160MP0000249_abnormal_blood_vessel0.19980343
161MP0003011_delayed_dark_adaptation0.19023826
162MP0003634_abnormal_glial_cell0.18618655

Predicted human phenotypes

RankGene SetZ-score
1Flat occiput (HP:0005469)9.52363069
2Delayed closure of the anterior fontanelle (HP:0001476)9.42132371
3Nasal polyposis (HP:0100582)6.56178545
4Autoimmune thrombocytopenia (HP:0001973)6.17398884
5Recurrent cutaneous fungal infections (HP:0011370)5.65546673
6Chronic mucocutaneous candidiasis (HP:0002728)5.65546673
7Epiphyseal stippling (HP:0010655)5.55375192
8Primary adrenal insufficiency (HP:0008207)5.46186569
9Abnormality of the nasal mucosa (HP:0000433)5.39372535
10Keratoconjunctivitis (HP:0001096)4.99445157
11Posterior embryotoxon (HP:0000627)4.89456244
12Abnormality of the line of Schwalbe (HP:0008048)4.75053541
13Stomatitis (HP:0010280)4.59912575
14Female pseudohermaphroditism (HP:0010458)4.56353334
15Delayed cranial suture closure (HP:0000270)4.52495789
16Thickened nuchal skin fold (HP:0000474)4.50435673
17Abnormality of B cell number (HP:0010975)4.27078341
18Abnormality of calcium-phosphate metabolism (HP:0100530)4.14553321
19Birth length less than 3rd percentile (HP:0003561)4.12345680
20Recurrent fungal infections (HP:0002841)3.99994343
21Abnormal epiphyseal ossification (HP:0010656)3.87409253
22Homocystinuria (HP:0002156)3.79079714
23Abnormality of homocysteine metabolism (HP:0010919)3.79079714
24Pustule (HP:0200039)3.74205424
25Stomach cancer (HP:0012126)3.73467618
26Hypercortisolism (HP:0001578)3.71963267
27Alopecia of scalp (HP:0002293)3.67897210
28Syringomyelia (HP:0003396)3.65282874
29Spinal cord lesions (HP:0100561)3.65282874
30Type I diabetes mellitus (HP:0100651)3.43206090
31Hypoparathyroidism (HP:0000829)3.37818241
32Methylmalonic acidemia (HP:0002912)3.36846813
33Autoimmune hemolytic anemia (HP:0001890)3.36005251
34Underdeveloped supraorbital ridges (HP:0009891)3.35268433
35Chromsome breakage (HP:0040012)3.34736527
36Increased IgM level (HP:0003496)3.26759229
37Agnosia (HP:0010524)3.20532873
38Chromosomal breakage induced by crosslinking agents (HP:0003221)3.11686794
39Oral leukoplakia (HP:0002745)3.00127696
40Supernumerary spleens (HP:0009799)2.95552077
41Pyloric stenosis (HP:0002021)2.94137173
42Aplastic anemia (HP:0001915)2.89734498
43Abnormal hair whorl (HP:0010721)2.88581213
44Abnormal delayed hypersensitivity skin test (HP:0002963)2.74996873
45Agammaglobulinemia (HP:0004432)2.69840885
46Abnormality of methionine metabolism (HP:0010901)2.68924103
47Abnormality of T cell physiology (HP:0011840)2.67449704
48Reticulocytopenia (HP:0001896)2.61374140
49External ear malformation (HP:0008572)2.57858617
50Abnormality of chromosome stability (HP:0003220)2.57755868
51Volvulus (HP:0002580)2.49781724
52Ectopic kidney (HP:0000086)2.48918565
53Respiratory distress (HP:0002098)2.48283062
54Abnormality of cells of the lymphoid lineage (HP:0012140)2.47423024
55Abnormality of the columella (HP:0009929)2.47120913
56True hermaphroditism (HP:0010459)2.44971059
57Premature graying of hair (HP:0002216)2.43506244
58Increased IgE level (HP:0003212)2.43064910
59Breast hypoplasia (HP:0003187)2.42949283
60Abnormal number of erythroid precursors (HP:0012131)2.41410561
61Abnormality of cells of the erythroid lineage (HP:0012130)2.41239470
62Keratitis (HP:0000491)2.41195156
63Cholelithiasis (HP:0001081)2.39572091
64Abnormality of the preputium (HP:0100587)2.38930339
65Abnormal number of incisors (HP:0011064)2.38657041
66Asplenia (HP:0001746)2.35666264
67Tetany (HP:0001281)2.34500739
68Myelodysplasia (HP:0002863)2.32839098
69Pancreatic fibrosis (HP:0100732)2.32256403
70Megaloblastic anemia (HP:0001889)2.30681322
7111 pairs of ribs (HP:0000878)2.30280860
72Recurrent abscess formation (HP:0002722)2.29329610
73Abnormal drinking behavior (HP:0030082)2.28642191
74Polydipsia (HP:0001959)2.28642191
75Meckel diverticulum (HP:0002245)2.26124346
76Cerebellar dysplasia (HP:0007033)2.25904042
77Aplasia/Hypoplasia of the uvula (HP:0010293)2.25369053
78Acute myeloid leukemia (HP:0004808)2.21810030
79Abnormal gallbladder morphology (HP:0012437)2.20608373
80Aplasia/Hypoplasia of the spleen (HP:0010451)2.19825625
81Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.19715643
82Hypoplasia of the pons (HP:0012110)2.19241440
83Colon cancer (HP:0003003)2.17082554
84Methylmalonic aciduria (HP:0012120)2.17075060
85Patellar aplasia (HP:0006443)2.17034078
86Bone marrow hypocellularity (HP:0005528)2.16854491
87Recurrent skin infections (HP:0001581)2.15211888
88Lymphoma (HP:0002665)2.14564865
89Abnormality of T cells (HP:0002843)2.14373575
90Medulloblastoma (HP:0002885)2.12956700
91Hypochromic anemia (HP:0001931)2.12884921
92Hypomagnesemia (HP:0002917)2.12415858
93Cellular immunodeficiency (HP:0005374)2.11605571
94Irregular epiphyses (HP:0010582)2.10976138
95Abnormality of the ileum (HP:0001549)2.10134330
96Abnormality of the vitamin B12 metabolism (HP:0004341)2.09119477
97Triangular face (HP:0000325)2.08620187
98Rough bone trabeculation (HP:0100670)2.08330360
99Abnormality of the labia minora (HP:0012880)2.08287371
100Short tibia (HP:0005736)2.07826146
101Facial hemangioma (HP:0000329)2.07410900
102Premature birth (HP:0001622)2.06634045
103Pancreatic cysts (HP:0001737)2.05349864
104Abnormal lung lobation (HP:0002101)2.02821153
105Abnormality of T cell number (HP:0011839)2.02355224
106Type I transferrin isoform profile (HP:0003642)2.00674587
107Abnormality of the pons (HP:0007361)2.00172759
108Brushfield spots (HP:0001088)10.6336936
109Pancytopenia (HP:0001876)1.99934292
110Long eyelashes (HP:0000527)1.99179400
111Chronic diarrhea (HP:0002028)1.99166394
112Increased density of long bones (HP:0006392)1.97794187
113Nephroblastoma (Wilms tumor) (HP:0002667)1.97706385
114Recurrent bacterial skin infections (HP:0005406)1.97203867
115Acute lymphatic leukemia (HP:0006721)1.96888073
116Preaxial hand polydactyly (HP:0001177)1.95712769
117Short middle phalanx of the 5th finger (HP:0004220)1.93973895
118Aplasia/Hypoplasia of the patella (HP:0006498)1.93628210
119Sloping forehead (HP:0000340)1.93415954
120Abnormality of vitamin B metabolism (HP:0004340)1.93079941
121Loss of speech (HP:0002371)1.93073285
122Polyphagia (HP:0002591)1.91727035
123Abnormality of the incisor (HP:0000676)1.89796767
124Aplasia/Hypoplasia of the tibia (HP:0005772)1.89436076
125Abnormality of aspartate family amino acid metabolism (HP:0010899)1.89382203
126Embryonal renal neoplasm (HP:0011794)1.85367207
127Small intestinal stenosis (HP:0012848)1.84905843
128Duodenal stenosis (HP:0100867)1.84905843
129Disinhibition (HP:0000734)1.84230329
130Triphalangeal thumb (HP:0001199)1.83444592
131Pallor (HP:0000980)1.82765015
132Fibular aplasia (HP:0002990)1.81566927
133Fair hair (HP:0002286)1.81461092
134Adrenal overactivity (HP:0002717)1.80636529
135Hypergammaglobulinemia (HP:0010702)1.80579688
136Eosinophilia (HP:0001880)1.79385004
137Type II lissencephaly (HP:0007260)1.78934201
138Leukopenia (HP:0001882)1.78143557
139Abdominal situs inversus (HP:0003363)1.78029866
140Abnormality of abdominal situs (HP:0011620)1.78029866
141Neutropenia (HP:0001875)1.77378650
142Abnormality of the prostate (HP:0008775)1.77089769
143Cheilitis (HP:0100825)1.76256797
144Lymphopenia (HP:0001888)1.76253446
145Gastrointestinal stroma tumor (HP:0100723)1.75949806
146Patchy hypopigmentation of hair (HP:0011365)1.75448741
147Adrenal hypoplasia (HP:0000835)1.74102615
148Optic nerve coloboma (HP:0000588)1.73903550
149Supernumerary bones of the axial skeleton (HP:0009144)1.73672956
150Protruding tongue (HP:0010808)1.73669023
151White forelock (HP:0002211)1.72571675
152Sclerocornea (HP:0000647)1.71742642
153Thyroid-stimulating hormone excess (HP:0002925)1.71485900
154Anencephaly (HP:0002323)1.71408468
155Hepatitis (HP:0012115)1.70506234
156Clubbing of toes (HP:0100760)1.70175238
157Abnormal trabecular bone morphology (HP:0100671)1.69140387
158Inappropriate behavior (HP:0000719)1.68750733
159Opacification of the corneal stroma (HP:0007759)1.68710836
160Abnormality of eosinophils (HP:0001879)1.68073304
161Hypoplasia of dental enamel (HP:0006297)1.68049357
162Thyroiditis (HP:0100646)1.67715192
163Single transverse palmar crease (HP:0000954)1.67317981
164Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.66816103
165Absent epiphyses (HP:0010577)1.66816103
166Abnormality of the duodenum (HP:0002246)1.66645266
167Hypopigmented skin patches (HP:0001053)1.65850572
168Aseptic necrosis (HP:0010885)1.64924455
169Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.63995382
170Macrocytic anemia (HP:0001972)1.63932278
171Abnormality of the fingertips (HP:0001211)1.63817616
172Intestinal atresia (HP:0011100)1.63631906
173Recurrent viral infections (HP:0004429)1.63472879
174Cleft eyelid (HP:0000625)1.63216998
175Intestinal fistula (HP:0100819)1.63093495
176Microtia (HP:0008551)1.62848049
177IgG deficiency (HP:0004315)1.62594743
178Hypoplasia of the capital femoral epiphysis (HP:0003090)1.61703579
179Increased hepatocellular lipid droplets (HP:0006565)1.61678760
180Pulmonary fibrosis (HP:0002206)1.61634679
181Xanthomatosis (HP:0000991)1.59331358
182IgM deficiency (HP:0002850)1.58699046
183Capillary hemangiomas (HP:0005306)1.58593630
184Slender build (HP:0001533)1.57771612
185Supernumerary ribs (HP:0005815)1.57143439
186Proximal placement of thumb (HP:0009623)1.56899868
187Amaurosis fugax (HP:0100576)1.56372182
188Granulocytopenia (HP:0001913)1.55557214
189Thrombocytosis (HP:0001894)1.55407366

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CAMKK13.88817289
2CDC73.59838545
3WEE13.50262960
4FGR3.28749515
5ITK3.26194996
6MKNK13.06015741
7STK162.86120388
8SRPK12.62717191
9BLK2.57647667
10EIF2AK12.42281211
11MKNK22.37291846
12VRK12.18817342
13BUB12.14892864
14MAP3K121.91906518
15IRAK41.72252287
16BRSK21.67146230
17PLK31.67071988
18ATR1.63610239
19PLK41.61812247
20EIF2AK21.54682285
21CSK1.54036821
22NME21.53444289
23MAP3K71.52715530
24TSSK61.45364687
25DYRK31.44150288
26ACVR1B1.42654335
27FGFR11.42161820
28STK101.41513028
29PKN11.39043908
30TXK1.38685975
31IRAK31.33887747
32PLK11.33374664
33NEK91.32126914
34PLK21.30909315
35TNIK1.30810966
36CDK71.30516689
37EIF2AK31.30447848
38GRK71.29087644
39PNCK1.28921996
40KIT1.26960380
41CASK1.26443307
42YES11.22708116
43TEC1.18202833
44RPS6KA41.17691679
45NEK61.07945730
46AURKB1.07364347
47CDK121.06419975
48GSK3A1.05820295
49JAK11.05739067
50CHEK21.05016071
51SIK31.02473598
52TTK1.02220527
53NEK20.99724551
54CHEK10.99303495
55ATM0.97271606
56SCYL20.94859394
57CDK190.94130621
58MAP4K10.93428033
59BCR0.93036153
60PBK0.92918160
61NUAK10.91789987
62PASK0.91225967
63MAPK70.88011691
64BRD40.87354664
65CLK10.82180052
66CDK40.82083103
67PIM20.79572854
68JAK30.78552929
69TLK10.78276940
70LYN0.78211762
71MAP3K140.73902495
72SIK10.70556003
73TESK20.70332787
74DYRK20.70032742
75CDK20.69503705
76BTK0.69204252
77STK30.69081038
78CDK30.68427684
79CDK10.68162685
80CHUK0.66579328
81RIPK40.65212827
82CSNK2A10.64288051
83BRSK10.63361019
84TGFBR10.62196267
85CDK80.62088812
86ERBB30.60350350
87TYK20.59444395
88RPS6KA50.58984686
89CCNB10.57242888
90PIM10.57157586
91KDR0.57015913
92MST40.56526627
93TGFBR20.55720132
94SYK0.55133470
95PIK3CA0.54708423
96ZAK0.54451182
97BMPR1B0.54321373
98ALK0.54130982
99MOS0.53447977
100ADRBK20.52393585
101PRKCQ0.52391331
102MAP3K130.51382591
103AURKA0.51163027
104MAPK120.50804956
105LCK0.50655010
106MAP3K110.50612891
107CSNK2A20.49649687
108CSNK1G30.48268258
109MARK30.48158690
110MAP3K80.46829393
111WNK30.45278170
112STK40.45227821
113MELK0.43972425
114CDK90.43962974
115CSF1R0.43576752
116IRAK10.40880799
117CSNK1G10.40697074
118RPS6KB10.40283516
119MAPK130.39243851
120IKBKB0.38530984
121MAP2K40.33614537
122FYN0.29667661
123PRKAA20.27287911
124CSNK1A10.26523187
125ERBB40.26407754
126GRK10.21897404
127LRRK20.21897095
128PRKDC0.20763219
129PRKG20.19369109
130ABL10.18901122
131RPS6KB20.18737856
132SGK10.18682248
133MAP4K20.17822343
134INSRR0.17652096
135JAK20.15479721
136OBSCN0.14688344
137TIE10.13176670
138MAP3K50.12342781
139IKBKE0.10080185
140PDK10.10018994
141PIK3CG0.09643747
142CAMK2B0.08872408
143FRK0.08395638
144CSNK1A1L0.06241216
145MAPK40.06176349
146MUSK0.05546789
147UHMK10.05050944
148TAF10.04925938
149NEK10.03925741
150CSNK1G20.03925390

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.08868694
2Mismatch repair_Homo sapiens_hsa034303.63169760
3RNA polymerase_Homo sapiens_hsa030203.39269125
4Homologous recombination_Homo sapiens_hsa034403.06774970
5Ribosome_Homo sapiens_hsa030102.98448281
6Spliceosome_Homo sapiens_hsa030402.93696942
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.88209436
8Base excision repair_Homo sapiens_hsa034102.77550334
9Non-homologous end-joining_Homo sapiens_hsa034502.70539168
10Cell cycle_Homo sapiens_hsa041102.52663206
11* RNA transport_Homo sapiens_hsa030132.47434446
12Fanconi anemia pathway_Homo sapiens_hsa034602.40597691
13Nucleotide excision repair_Homo sapiens_hsa034202.38140539
14Pyrimidine metabolism_Homo sapiens_hsa002402.26007511
15Proteasome_Homo sapiens_hsa030502.25031403
16Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.16002565
17RNA degradation_Homo sapiens_hsa030182.10578674
18Vitamin digestion and absorption_Homo sapiens_hsa049771.97821599
19Peroxisome_Homo sapiens_hsa041461.83522074
20Basal transcription factors_Homo sapiens_hsa030221.83412805
21Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.78893338
22Cardiac muscle contraction_Homo sapiens_hsa042601.67510468
23mRNA surveillance pathway_Homo sapiens_hsa030151.65479226
24Mineral absorption_Homo sapiens_hsa049781.55548692
25Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.47137899
26Dorso-ventral axis formation_Homo sapiens_hsa043201.38607551
27p53 signaling pathway_Homo sapiens_hsa041151.37731820
28Protein export_Homo sapiens_hsa030601.37376977
29Herpes simplex infection_Homo sapiens_hsa051681.35594832
30One carbon pool by folate_Homo sapiens_hsa006701.33518075
31Purine metabolism_Homo sapiens_hsa002301.26664009
32Epstein-Barr virus infection_Homo sapiens_hsa051691.26211679
33Measles_Homo sapiens_hsa051621.14814783
34Primary immunodeficiency_Homo sapiens_hsa053401.13796563
35NF-kappa B signaling pathway_Homo sapiens_hsa040641.11829077
36Antigen processing and presentation_Homo sapiens_hsa046121.10203581
37Allograft rejection_Homo sapiens_hsa053301.06048296
38Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.03879762
39Asthma_Homo sapiens_hsa053100.99877990
40Tyrosine metabolism_Homo sapiens_hsa003500.98540991
41Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.98201884
42NOD-like receptor signaling pathway_Homo sapiens_hsa046210.95589779
43Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.93675595
44Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.91736432
45African trypanosomiasis_Homo sapiens_hsa051430.90772579
46Retinol metabolism_Homo sapiens_hsa008300.87442648
47Circadian rhythm_Homo sapiens_hsa047100.87261730
48Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.85963258
49Dilated cardiomyopathy_Homo sapiens_hsa054140.84269894
50Transcriptional misregulation in cancer_Homo sapiens_hsa052020.83773962
51Caffeine metabolism_Homo sapiens_hsa002320.83384449
52Hematopoietic cell lineage_Homo sapiens_hsa046400.81356736
53Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.80783395
54Huntingtons disease_Homo sapiens_hsa050160.79650447
55Leishmaniasis_Homo sapiens_hsa051400.79100292
56Oocyte meiosis_Homo sapiens_hsa041140.78772816
57Rheumatoid arthritis_Homo sapiens_hsa053230.76270318
58Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.75235757
59Autoimmune thyroid disease_Homo sapiens_hsa053200.74980083
60Viral carcinogenesis_Homo sapiens_hsa052030.74877710
61Intestinal immune network for IgA production_Homo sapiens_hsa046720.74431376
62Selenocompound metabolism_Homo sapiens_hsa004500.73596778
63Sulfur relay system_Homo sapiens_hsa041220.73457912
64HTLV-I infection_Homo sapiens_hsa051660.73310218
65Hepatitis B_Homo sapiens_hsa051610.72811014
66B cell receptor signaling pathway_Homo sapiens_hsa046620.70065700
67TNF signaling pathway_Homo sapiens_hsa046680.68037062
68Graft-versus-host disease_Homo sapiens_hsa053320.66930625
69Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.66073851
70Systemic lupus erythematosus_Homo sapiens_hsa053220.66018799
71Shigellosis_Homo sapiens_hsa051310.63182548
72RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.62066519
73Legionellosis_Homo sapiens_hsa051340.60164363
74MicroRNAs in cancer_Homo sapiens_hsa052060.60034341
75Influenza A_Homo sapiens_hsa051640.57482971
76Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.56563460
77TGF-beta signaling pathway_Homo sapiens_hsa043500.56085078
78Tight junction_Homo sapiens_hsa045300.54627429
79Type I diabetes mellitus_Homo sapiens_hsa049400.53312687
80Parkinsons disease_Homo sapiens_hsa050120.52835152
81Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.52257201
82Viral myocarditis_Homo sapiens_hsa054160.50399770
83Toll-like receptor signaling pathway_Homo sapiens_hsa046200.50354540
84Apoptosis_Homo sapiens_hsa042100.50224910
85FoxO signaling pathway_Homo sapiens_hsa040680.49179224
86Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.49054422
87Osteoclast differentiation_Homo sapiens_hsa043800.48799101
88T cell receptor signaling pathway_Homo sapiens_hsa046600.47405541
89Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.47257775
90Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.46910708
91Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.46662973
92Jak-STAT signaling pathway_Homo sapiens_hsa046300.46013958
93Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.44685401
94Oxidative phosphorylation_Homo sapiens_hsa001900.43582103
95Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.43482265
96Pertussis_Homo sapiens_hsa051330.42605858
97Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.42537037
98Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.41971216
99Acute myeloid leukemia_Homo sapiens_hsa052210.41552278
100Colorectal cancer_Homo sapiens_hsa052100.41540383
101Malaria_Homo sapiens_hsa051440.40697890
102MAPK signaling pathway_Homo sapiens_hsa040100.40571541
103Notch signaling pathway_Homo sapiens_hsa043300.39392479
104Tuberculosis_Homo sapiens_hsa051520.39122692
105Phagosome_Homo sapiens_hsa041450.38806385
106Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.37962322
107Arachidonic acid metabolism_Homo sapiens_hsa005900.37762923
108Small cell lung cancer_Homo sapiens_hsa052220.37211292
109Phototransduction_Homo sapiens_hsa047440.36520271
110Maturity onset diabetes of the young_Homo sapiens_hsa049500.35511556
111Other glycan degradation_Homo sapiens_hsa005110.35362578
112Basal cell carcinoma_Homo sapiens_hsa052170.35254642
113Chemokine signaling pathway_Homo sapiens_hsa040620.34860982
114Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.34646795
115Hedgehog signaling pathway_Homo sapiens_hsa043400.34590029
116Pathways in cancer_Homo sapiens_hsa052000.34468772
117Alzheimers disease_Homo sapiens_hsa050100.32962931
118Sulfur metabolism_Homo sapiens_hsa009200.32179629
119Complement and coagulation cascades_Homo sapiens_hsa046100.31947223
120Cysteine and methionine metabolism_Homo sapiens_hsa002700.31191083
121Salmonella infection_Homo sapiens_hsa051320.29402135
122Wnt signaling pathway_Homo sapiens_hsa043100.29296084
123Type II diabetes mellitus_Homo sapiens_hsa049300.29033471
124Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.28858432
125N-Glycan biosynthesis_Homo sapiens_hsa005100.27087183
126Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.26023436
127Regulation of autophagy_Homo sapiens_hsa041400.25643959
128Alcoholism_Homo sapiens_hsa050340.25587847
129Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.25529354
130Pancreatic cancer_Homo sapiens_hsa052120.25440110
131SNARE interactions in vesicular transport_Homo sapiens_hsa041300.24848157
132Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.24285515
133Staphylococcus aureus infection_Homo sapiens_hsa051500.24153238
134cAMP signaling pathway_Homo sapiens_hsa040240.24122938
135Collecting duct acid secretion_Homo sapiens_hsa049660.23768727
136Sphingolipid metabolism_Homo sapiens_hsa006000.23261250
137Toxoplasmosis_Homo sapiens_hsa051450.23165050
138Hippo signaling pathway_Homo sapiens_hsa043900.22579776
139Fructose and mannose metabolism_Homo sapiens_hsa000510.21013198
140Chronic myeloid leukemia_Homo sapiens_hsa052200.15094004

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