TGM5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the transglutaminase family. The encoded protein catalyzes formation of protein cross-links between glutamine and lysine residues, often resulting in stabilization of protein assemblies. This reaction is calcium dependent. Mutations in this gene have been associated with acral peeling skin syndrome. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1establishment of skin barrier (GO:0061436)9.43783825
2regulation of water loss via skin (GO:0033561)8.34306138
3negative regulation of T cell mediated immunity (GO:0002710)6.32930134
4keratinocyte proliferation (GO:0043616)6.30272644
5keratinization (GO:0031424)6.27085793
6negative regulation of type 2 immune response (GO:0002829)6.20222398
7multicellular organismal water homeostasis (GO:0050891)5.99307380
8phosphatidylinositol acyl-chain remodeling (GO:0036149)5.59243768
9phosphatidylserine acyl-chain remodeling (GO:0036150)5.55937180
10outer ear morphogenesis (GO:0042473)5.31367082
11embryonic viscerocranium morphogenesis (GO:0048703)5.19560530
12keratinocyte development (GO:0003334)4.94940473
13viral transcription (GO:0019083)4.92862773
14water homeostasis (GO:0030104)4.91787942
15G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071994.90432266
16negative regulation of keratinocyte proliferation (GO:0010839)4.84974113
17bundle of His cell to Purkinje myocyte communication (GO:0086069)4.84855032
18keratinocyte differentiation (GO:0030216)4.63568922
19regulation of phospholipase A2 activity (GO:0032429)4.58858168
20translational termination (GO:0006415)4.57684363
21phosphatidylethanolamine acyl-chain remodeling (GO:0036152)4.49725552
22* peptide cross-linking (GO:0018149)4.41279340
23regulation of interleukin-13 production (GO:0032656)4.39047210
24long-chain fatty acid biosynthetic process (GO:0042759)4.36677731
25epidermal cell differentiation (GO:0009913)4.35798911
26* epidermis development (GO:0008544)4.33142181
27ribosomal small subunit biogenesis (GO:0042274)4.32710666
28DNA deamination (GO:0045006)4.25487002
29regulation of cell proliferation involved in kidney development (GO:1901722)4.22131098
30sphingoid metabolic process (GO:0046519)4.21733467
31phosphatidylcholine acyl-chain remodeling (GO:0036151)4.12183447
32negative regulation of lymphocyte mediated immunity (GO:0002707)4.06838185
33negative regulation of inflammatory response to antigenic stimulus (GO:0002862)3.99037953
34phosphatidylglycerol acyl-chain remodeling (GO:0036148)3.98209438
35lymph vessel development (GO:0001945)3.89393645
36middle ear morphogenesis (GO:0042474)3.89050553
37heart valve morphogenesis (GO:0003179)3.79567603
38detection of bacterium (GO:0016045)3.77486063
39planar cell polarity pathway involved in neural tube closure (GO:0090179)3.68078078
40cellular protein complex disassembly (GO:0043624)3.67579570
41cytidine metabolic process (GO:0046087)3.65620855
42cytidine catabolic process (GO:0006216)3.65620855
43cytidine deamination (GO:0009972)3.65620855
44SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.62421709
45cellular response to vitamin D (GO:0071305)3.60783037
46protein K11-linked deubiquitination (GO:0035871)3.55812066
47protein targeting to ER (GO:0045047)3.55762715
48indolalkylamine metabolic process (GO:0006586)3.54201065
49ribosomal small subunit assembly (GO:0000028)3.53595722
50cotranslational protein targeting to membrane (GO:0006613)3.53427733
51regulation of transforming growth factor beta1 production (GO:0032908)3.52920343
52viral life cycle (GO:0019058)3.52547566
53negative regulation of cytokine production involved in immune response (GO:0002719)3.50475536
54positive regulation of glomerulus development (GO:0090193)3.49343327
55intermediate filament organization (GO:0045109)3.45946740
56hydrogen peroxide biosynthetic process (GO:0050665)3.45711805
57translational elongation (GO:0006414)3.44911082
58establishment of protein localization to endoplasmic reticulum (GO:0072599)3.44582746
59positive regulation of vesicle fusion (GO:0031340)3.42828819
60negative regulation of cell fate specification (GO:0009996)3.42220903
61negative regulation of cell fate commitment (GO:0010454)3.40977041
62molting cycle (GO:0042303)3.35393366
63hair cycle (GO:0042633)3.35393366
64sphingosine metabolic process (GO:0006670)3.34575863
65kynurenine metabolic process (GO:0070189)3.31879103
66protein localization to endoplasmic reticulum (GO:0070972)3.29747571
67linoleic acid metabolic process (GO:0043651)3.29373163
68G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)3.28996418
69regulation of T cell cytokine production (GO:0002724)3.28584357
70segment specification (GO:0007379)3.25622555
71detection of other organism (GO:0098543)3.24754134
72regulation of interleukin-5 production (GO:0032674)3.24232637
73negative regulation of adaptive immune response based on somatic recombination of immune receptors b3.24096621
74regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.20045209
75regulation of ruffle assembly (GO:1900027)3.17272565
76positive regulation of developmental pigmentation (GO:0048087)3.16532939
77fucose catabolic process (GO:0019317)3.16248499
78L-fucose metabolic process (GO:0042354)3.16248499
79L-fucose catabolic process (GO:0042355)3.16248499
80tryptophan catabolic process (GO:0006569)3.16193363
81indole-containing compound catabolic process (GO:0042436)3.16193363
82indolalkylamine catabolic process (GO:0046218)3.16193363
83heart valve formation (GO:0003188)3.15768564
84phosphatidylserine metabolic process (GO:0006658)3.15185451
85negative regulation of erythrocyte differentiation (GO:0045647)3.14949338
86regulation of hair follicle development (GO:0051797)3.14806175
87purinergic nucleotide receptor signaling pathway (GO:0035590)3.14378415
88positive regulation of defense response to virus by host (GO:0002230)3.14137795
89phospholipid scrambling (GO:0017121)3.09384244
90reactive oxygen species biosynthetic process (GO:1903409)3.07039252
91nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.06434636
92hair follicle morphogenesis (GO:0031069)3.06220544
93lipoxygenase pathway (GO:0019372)3.05176006
94positive regulation of tyrosine phosphorylation of Stat3 protein (GO:0042517)3.04694964
95regulation of keratinocyte proliferation (GO:0010837)3.03998564
96DNA demethylation (GO:0080111)3.03273232
97DNA methylation involved in gamete generation (GO:0043046)3.02795914
98regulation of natural killer cell differentiation (GO:0032823)3.02626972
99negative regulation of viral entry into host cell (GO:0046597)3.01142879
100protein complex disassembly (GO:0043241)3.00728690
101neural crest cell development (GO:0014032)3.00539968
102regulation of type 2 immune response (GO:0002828)2.99304702
103negative regulation of dendrite morphogenesis (GO:0050774)2.98033410
104negative regulation of activin receptor signaling pathway (GO:0032926)2.95037999
105mammary gland epithelial cell differentiation (GO:0060644)2.92543948
106ectoderm development (GO:0007398)2.91723499
107regulation of T cell chemotaxis (GO:0010819)2.90539982
108positive regulation of T cell chemotaxis (GO:0010820)2.90539982
109tryptophan metabolic process (GO:0006568)2.90228668
110limb bud formation (GO:0060174)2.89557557
111skin morphogenesis (GO:0043589)2.89196382
112diol metabolic process (GO:0034311)2.88753551
113gland morphogenesis (GO:0022612)2.88655311
114intermediate filament cytoskeleton organization (GO:0045104)2.88291992
115mesenchymal-epithelial cell signaling (GO:0060638)2.88228528
116mesenchymal to epithelial transition (GO:0060231)2.88220105
117intermediate filament-based process (GO:0045103)2.87038049
118cell-substrate junction assembly (GO:0007044)2.86520854
119behavioral response to nicotine (GO:0035095)2.85038971
120auditory receptor cell differentiation (GO:0042491)2.84907854
121transepithelial transport (GO:0070633)2.84472631
122regulation of male gonad development (GO:2000018)2.84136683
123positive regulation of hair cycle (GO:0042635)2.83942077
124positive regulation of hair follicle development (GO:0051798)2.83942077
125membrane budding (GO:0006900)2.83861053
126fatty acid elongation (GO:0030497)2.82380895
127regulation of glomerulus development (GO:0090192)2.81779621
128cellular response to vitamin (GO:0071295)2.79768500
129pyrimidine ribonucleoside catabolic process (GO:0046133)2.79001705
130regulation of meiosis I (GO:0060631)2.78888185
131regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.78090896
132cellular ketone body metabolic process (GO:0046950)2.76985895
133positive regulation of prostaglandin secretion (GO:0032308)2.76122472
134negative regulation of adaptive immune response (GO:0002820)2.74557334
135macromolecular complex disassembly (GO:0032984)2.73338431
136ephrin receptor signaling pathway (GO:0048013)2.73268190
137regulation of apoptotic process involved in morphogenesis (GO:1902337)2.72700439
138detection of light stimulus involved in visual perception (GO:0050908)2.67601697
139detection of light stimulus involved in sensory perception (GO:0050962)2.67601697
140protein targeting to membrane (GO:0006612)2.67118112
141protein K6-linked ubiquitination (GO:0085020)2.66147794
142negative regulation of mesenchymal cell apoptotic process (GO:2001054)2.66006265
143notochord development (GO:0030903)2.65811231
144sympathetic nervous system development (GO:0048485)2.64668661
145sulfate transmembrane transport (GO:1902358)2.63666271
146regulation of heart morphogenesis (GO:2000826)2.63156234
147negative regulation of production of molecular mediator of immune response (GO:0002701)2.61287739
148negative regulation of chondrocyte differentiation (GO:0032331)2.60092102
149sphingolipid biosynthetic process (GO:0030148)2.59792701
150phospholipid catabolic process (GO:0009395)2.58867745
151CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.58205256
152cartilage morphogenesis (GO:0060536)2.58070918
153one-carbon compound transport (GO:0019755)2.57767356
154piRNA metabolic process (GO:0034587)2.57188355
155negative regulation of calcium ion transport into cytosol (GO:0010523)2.56556090
156positive regulation of T-helper 1 type immune response (GO:0002827)2.56158881
157lateral sprouting from an epithelium (GO:0060601)2.50193753
158alditol phosphate metabolic process (GO:0052646)2.49904261
159glycerophospholipid catabolic process (GO:0046475)2.47180127
160regulation of B cell receptor signaling pathway (GO:0050855)2.45527554
161indole-containing compound metabolic process (GO:0042430)2.43211811
162ceramide biosynthetic process (GO:0046513)2.42805957
163regulation of axon regeneration (GO:0048679)2.40913158
164regulation of neuron projection regeneration (GO:0070570)2.40913158
165lymphoid progenitor cell differentiation (GO:0002320)2.39800122
166phosphatidylglycerol metabolic process (GO:0046471)2.37287526
167histone H3-K4 trimethylation (GO:0080182)2.36707771
168ketone body metabolic process (GO:1902224)2.36632286
169interkinetic nuclear migration (GO:0022027)2.36436357
170sulfate transport (GO:0008272)2.35520078
171inner ear receptor cell differentiation (GO:0060113)2.35373358
172regulation of defense response to virus by host (GO:0050691)2.35062865
173DNA dealkylation (GO:0035510)2.34725374
174amine catabolic process (GO:0009310)2.34598544
175cellular biogenic amine catabolic process (GO:0042402)2.34598544
176negative regulation of mast cell activation (GO:0033004)2.32587020
177desmosome organization (GO:0002934)13.3330660
178hemidesmosome assembly (GO:0031581)10.3139201

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse5.48937222
2* SOX9_24532713_ChIP-Seq_HFSC_Mouse3.80989516
3ESR1_21235772_ChIP-Seq_MCF-7_Human3.21460747
4ZNF274_21170338_ChIP-Seq_K562_Hela3.14662817
5FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.03893721
6VDR_22108803_ChIP-Seq_LS180_Human2.99660660
7IRF8_22096565_ChIP-ChIP_GC-B_Human2.62898846
8SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.44106868
9ESR2_21235772_ChIP-Seq_MCF-7_Human2.36166730
10NOTCH1_21737748_ChIP-Seq_TLL_Human2.35626901
11P63_26484246_Chip-Seq_KERATINOCYTES_Human2.29262886
12CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.18112448
13TRIM28_21343339_ChIP-Seq_HEK293_Human2.12133874
14GBX2_23144817_ChIP-Seq_PC3_Human2.10957831
15SALL1_21062744_ChIP-ChIP_HESCs_Human2.05620694
16EED_16625203_ChIP-ChIP_MESCs_Mouse2.00455577
17TP63_17297297_ChIP-ChIP_HaCaT_Human11.6182613
18FLI1_27457419_Chip-Seq_LIVER_Mouse1.92023631
19CTBP2_25329375_ChIP-Seq_LNCAP_Human1.90689319
20SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.86961145
21POU3F2_20337985_ChIP-ChIP_501MEL_Human1.84963103
22SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.76309746
23FOXA1_25329375_ChIP-Seq_VCAP_Human1.75401661
24FOXA1_27270436_Chip-Seq_PROSTATE_Human1.75401661
25AR_21572438_ChIP-Seq_LNCaP_Human1.74753989
26AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.74330595
27ERG_21242973_ChIP-ChIP_JURKAT_Human1.73478652
28JARID2_20075857_ChIP-Seq_MESCs_Mouse1.73301580
29JARID2_20064375_ChIP-Seq_MESCs_Mouse1.73049628
30SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.72337839
31EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.72073628
32EGR1_23403033_ChIP-Seq_LIVER_Mouse1.71335512
33EZH2_27304074_Chip-Seq_ESCs_Mouse1.71121251
34VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.69908708
35SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.68369507
36SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.68369507
37P300_19829295_ChIP-Seq_ESCs_Human1.65656143
38SUZ12_27294783_Chip-Seq_NPCs_Mouse1.65124379
39SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.64930110
40RNF2_18974828_ChIP-Seq_MESCs_Mouse1.64502080
41EZH2_18974828_ChIP-Seq_MESCs_Mouse1.64502080
42SUZ12_27294783_Chip-Seq_ESCs_Mouse1.55817635
43TP53_18474530_ChIP-ChIP_U2OS_Human1.53907670
44TP53_20018659_ChIP-ChIP_R1E_Mouse1.53751037
45ER_23166858_ChIP-Seq_MCF-7_Human1.53622834
46FOXA1_21572438_ChIP-Seq_LNCaP_Human1.51680358
47NFE2_27457419_Chip-Seq_LIVER_Mouse1.50999441
48ZNF217_24962896_ChIP-Seq_MCF-7_Human1.48314726
49SOX2_19829295_ChIP-Seq_ESCs_Human1.47517631
50NANOG_19829295_ChIP-Seq_ESCs_Human1.47517631
51FOXO3_23340844_ChIP-Seq_DLD1_Human1.45400081
52BMI1_23680149_ChIP-Seq_NPCS_Mouse1.45366930
53NR3C1_21868756_ChIP-Seq_MCF10A_Human1.45243825
54RBPJ_22232070_ChIP-Seq_NCS_Mouse1.45144519
55EZH2_27294783_Chip-Seq_ESCs_Mouse1.44832928
56SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.44482506
57EZH2_27294783_Chip-Seq_NPCs_Mouse1.41958838
58NCOR_22424771_ChIP-Seq_293T_Human1.41346314
59MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.40963906
60STAT6_21828071_ChIP-Seq_BEAS2B_Human1.40566896
61GATA6_21074721_ChIP-Seq_CACO-2_Human1.40132880
62ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.39892587
63AR_25329375_ChIP-Seq_VCAP_Human1.39290219
64FUS_26573619_Chip-Seq_HEK293_Human1.34650518
65GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human1.32883927
66CBX2_27304074_Chip-Seq_ESCs_Mouse1.32630447
67RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.32628148
68EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.32593821
69UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.31985526
70RNF2_27304074_Chip-Seq_ESCs_Mouse1.31432211
71TP63_23658742_ChIP-Seq_EP156T_Human1.30665223
72GATA3_21878914_ChIP-Seq_MCF-7_Human1.30362552
73PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.29953648
74SOX2_20726797_ChIP-Seq_SW620_Human1.29688276
75IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.29474830
76BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.29183117
77VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.29153362
78STAT3_23295773_ChIP-Seq_U87_Human1.29091637
79CDX2_22108803_ChIP-Seq_LS180_Human1.28660433
80SMAD4_21799915_ChIP-Seq_A2780_Human1.28288476
81SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.27256482
82IRF1_19129219_ChIP-ChIP_H3396_Human1.26815289
83PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.26662969
84TCF4_18268006_ChIP-ChIP_LS174T_Human1.25904619
85EWS_26573619_Chip-Seq_HEK293_Human1.24901601
86SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.24067854
87KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.23429739
88KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.23429739
89KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.23429739
90IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.23230938
91CBP_20019798_ChIP-Seq_JUKART_Human1.23230938
92AR_20517297_ChIP-Seq_VCAP_Human1.22946170
93VDR_24787735_ChIP-Seq_THP-1_Human1.22389375
94IKZF1_21737484_ChIP-ChIP_HCT116_Human1.22296949
95GATA3_26560356_Chip-Seq_TH2_Human1.21578811
96BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.21412655
97MTF2_20144788_ChIP-Seq_MESCs_Mouse1.20416245
98STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.19011384
99POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.18901786
100TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.18901786
101KLF5_25053715_ChIP-Seq_YYC3_Human1.18765168
102TCF4_23295773_ChIP-Seq_U87_Human1.18737578
103BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.18067706
104ERG_20517297_ChIP-Seq_VCAP_Human1.17865391
105GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.17277971
106TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.16173867
107CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.16173047
108HIF1A_21447827_ChIP-Seq_MCF-7_Human1.15237460
109CRX_20693478_ChIP-Seq_RETINA_Mouse1.14909563
110AUTS2_25519132_ChIP-Seq_293T-REX_Human1.14774886
111HOXB7_26014856_ChIP-Seq_BT474_Human1.14675440
112CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.14533402
113HNFA_21074721_ChIP-Seq_CACO-2_Human1.13801651
114SMAD4_21741376_ChIP-Seq_EPCs_Human1.13199423
115NANOG_18555785_Chip-Seq_ESCs_Mouse1.13024716
116SMRT_27268052_Chip-Seq_Bcells_Human1.13014625
117PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.12000282
118KLF5_20875108_ChIP-Seq_MESCs_Mouse1.11442027
119CJUN_26792858_Chip-Seq_BT549_Human1.10451368
120SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.08577929
121GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.08390543
122FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.07566401
123STAT3_18555785_Chip-Seq_ESCs_Mouse1.07383190
124RBPJ_21746931_ChIP-Seq_IB4_Human1.06316978
125AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.06284391
126PHF8_20622853_ChIP-Seq_HELA_Human1.05879940
127SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.04621367
128PRDM14_20953172_ChIP-Seq_ESCs_Human1.03955695
129IRF8_21731497_ChIP-ChIP_J774_Mouse1.03611907
130CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.03608607
131CDX2_19796622_ChIP-Seq_MESCs_Mouse1.02980806
132RING1B_27294783_Chip-Seq_ESCs_Mouse1.00899802
133TAF15_26573619_Chip-Seq_HEK293_Human0.98960009
134EGR1_19032775_ChIP-ChIP_M12_Human0.97803380
135STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.97557533
136RUNX1_27514584_Chip-Seq_MCF-7_Human0.96839469
137TP53_16413492_ChIP-PET_HCT116_Human0.95039461
138* TP63_22573176_ChIP-Seq_HFKS_Human0.94534415
139RXR_22108803_ChIP-Seq_LS180_Human0.93518093
140RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.91259549
141PIAS1_25552417_ChIP-Seq_VCAP_Human0.88798521
142BCAT_22108803_ChIP-Seq_LS180_Human0.87954649
143ZNF263_19887448_ChIP-Seq_K562_Human0.87685642
144RNF2_27304074_Chip-Seq_NSC_Mouse0.86914742
145IGF1R_20145208_ChIP-Seq_DFB_Human0.86773172
146MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.85442362
147TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.84497685
148UBF1/2_26484160_Chip-Seq_HMECs_Human0.83087426
149AHR_22903824_ChIP-Seq_MCF-7_Human0.82894456
150CTCF_27219007_Chip-Seq_Bcells_Human0.80865599
151SMAD3_21741376_ChIP-Seq_HESCs_Human0.80103799
152FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.80075453
153PPAR_26484153_Chip-Seq_NCI-H1993_Human0.79965974
154RING1B_27294783_Chip-Seq_NPCs_Mouse0.79842085
155GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.77352255
156PCGF2_27294783_Chip-Seq_NPCs_Mouse0.77349243
157CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.77238907
158RARG_19884340_ChIP-ChIP_MEFs_Mouse0.76814493
159ZFP57_27257070_Chip-Seq_ESCs_Mouse0.76271501
160* TCF4_22108803_ChIP-Seq_LS180_Human0.75618729
161FOXM1_26456572_ChIP-Seq_MCF-7_Human0.75198965
162GATA4_25053715_ChIP-Seq_YYC3_Human0.73303917
163NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.71654158
164NRF2_20460467_ChIP-Seq_MEFs_Mouse0.71654158
165RACK7_27058665_Chip-Seq_MCF-7_Human0.71445814
166GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.71404566
167IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.71190945
168JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.65826808
169KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.65711832
170DNAJC2_21179169_ChIP-ChIP_NT2_Human0.65649377
171CTBP1_25329375_ChIP-Seq_LNCAP_Human0.65205670
172RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.64503095
173TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.64027717
174CDX2_20551321_ChIP-Seq_CACO-2_Human0.63875665
175UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.62531671
176PCGF2_27294783_Chip-Seq_ESCs_Mouse0.62273343
177* LXR_22292898_ChIP-Seq_THP-1_Human0.61788991

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010234_abnormal_vibrissa_follicle6.76836178
2MP0002796_impaired_skin_barrier5.64330321
3MP0003941_abnormal_skin_development5.15985710
4MP0005275_abnormal_skin_tensile3.98487131
5MP0005501_abnormal_skin_physiology3.64926406
6MP0002060_abnormal_skin_morphology3.59166739
7MP0002102_abnormal_ear_morphology3.41639772
8MP0004381_abnormal_hair_follicle3.25905063
9MP0000579_abnormal_nail_morphology3.10368136
10MP0002098_abnormal_vibrissa_morphology2.94936452
11MP0010678_abnormal_skin_adnexa2.90413093
12MP0000762_abnormal_tongue_morphology2.89511689
13MP0001216_abnormal_epidermal_layer2.89278588
14MP0005451_abnormal_body_composition2.73197329
15MP0010771_integument_phenotype2.65909494
16MP0000427_abnormal_hair_cycle2.64505705
17MP0003453_abnormal_keratinocyte_physiol2.61003040
18MP0002837_dystrophic_cardiac_calcinosis2.56568013
19MP0000383_abnormal_hair_follicle2.53284174
20MP0000647_abnormal_sebaceous_gland2.51988860
21MP0002249_abnormal_larynx_morphology2.39323814
22MP0002138_abnormal_hepatobiliary_system2.37163582
23MP0000377_abnormal_hair_follicle2.36109700
24MP0005075_abnormal_melanosome_morpholog2.27547090
25MP0004947_skin_inflammation2.13700400
26MP0002254_reproductive_system_inflammat2.08976719
27MP0003566_abnormal_cell_adhesion1.98072717
28MP0005645_abnormal_hypothalamus_physiol1.95307321
29MP0003705_abnormal_hypodermis_morpholog1.92374402
30MP0000467_abnormal_esophagus_morphology1.89791190
31MP0000569_abnormal_digit_pigmentation1.89267052
32MP0001346_abnormal_lacrimal_gland1.82021071
33MP0000015_abnormal_ear_pigmentation1.80327341
34MP0002009_preneoplasia1.75780575
35MP0000372_irregular_coat_pigmentation1.73870080
36MP0002234_abnormal_pharynx_morphology1.72866814
37MP0000049_abnormal_middle_ear1.71634673
38MP0005671_abnormal_response_to1.60791602
39MP0003045_fibrosis1.60131042
40MP0008789_abnormal_olfactory_epithelium1.56707798
41MP0001851_eye_inflammation1.56422981
42MP0000465_gastrointestinal_hemorrhage1.54947827
43MP0003763_abnormal_thymus_physiology1.52123618
44MP0003136_yellow_coat_color1.51386127
45MP0001191_abnormal_skin_condition1.49280092
46MP0000566_synostosis1.49009222
47MP0009931_abnormal_skin_appearance1.44672196
48MP0009379_abnormal_foot_pigmentation1.44304777
49MP0001849_ear_inflammation1.43690210
50MP0002177_abnormal_outer_ear1.42894639
51MP0001340_abnormal_eyelid_morphology1.39855738
52MP0005171_absent_coat_pigmentation1.34684718
53MP0000678_abnormal_parathyroid_gland1.30500469
54MP0002277_abnormal_respiratory_mucosa1.28564704
55MP0001800_abnormal_humoral_immune1.27654917
56MP0002282_abnormal_trachea_morphology1.24200176
57MP0000367_abnormal_coat/_hair1.23641905
58MP0005387_immune_system_phenotype1.23264748
59MP0001790_abnormal_immune_system1.23264748
60MP0004043_abnormal_pH_regulation1.21790151
61MP0002166_altered_tumor_susceptibility1.19003296
62MP0005508_abnormal_skeleton_morphology1.18923186
63MP0002233_abnormal_nose_morphology1.18472187
64MP0001243_abnormal_dermal_layer1.17488658
65MP0008877_abnormal_DNA_methylation1.15231311
66MP0010030_abnormal_orbit_morphology1.14977628
67MP0005394_taste/olfaction_phenotype1.14805104
68MP0005499_abnormal_olfactory_system1.14805104
69MP0000013_abnormal_adipose_tissue1.14480448
70MP0003878_abnormal_ear_physiology1.12832910
71MP0005377_hearing/vestibular/ear_phenot1.12832910
72MP0004019_abnormal_vitamin_homeostasis1.12278358
73MP0005647_abnormal_sex_gland1.11846951
74MP0002653_abnormal_ependyma_morphology1.11150727
75MP0008057_abnormal_DNA_replication1.09175822
76MP0001270_distended_abdomen1.06402650
77MP0008872_abnormal_physiological_respon1.05072009
78MP0005551_abnormal_eye_electrophysiolog1.02829924
79MP0002876_abnormal_thyroid_physiology1.01323787
80MP0002006_tumorigenesis0.99150172
81MP0001485_abnormal_pinna_reflex0.97121711
82MP0003195_calcinosis0.97018999
83MP0001919_abnormal_reproductive_system0.92298488
84MP0009046_muscle_twitch0.92184871
85MP0001501_abnormal_sleep_pattern0.92095454
86MP0001835_abnormal_antigen_presentation0.90972810
87MP0005409_darkened_coat_color0.89538810
88MP0000371_diluted_coat_color0.87756527
89MP0002896_abnormal_bone_mineralization0.85760592
90MP0010094_abnormal_chromosome_stability0.84670265
91MP0003755_abnormal_palate_morphology0.84195532
92MP0009384_cardiac_valve_regurgitation0.81860132
93MP0009250_abnormal_appendicular_skeleto0.81712230
94MP0004185_abnormal_adipocyte_glucose0.80821555
95MP0002163_abnormal_gland_morphology0.80027201
96MP0002452_abnormal_antigen_presenting0.78483791
97MP0009333_abnormal_splenocyte_physiolog0.77652067
98MP0005187_abnormal_penis_morphology0.76908155
99MP0002075_abnormal_coat/hair_pigmentati0.74999786
100MP0002723_abnormal_immune_serum0.74020204
101MP0005360_urolithiasis0.73712962
102MP0003011_delayed_dark_adaptation0.73677840
103MP0004264_abnormal_extraembryonic_tissu0.72673866
104MP0004272_abnormal_basement_membrane0.71753366
105MP0003646_muscle_fatigue0.71678562
106MP0002168_other_aberrant_phenotype0.71213249
107MP0000163_abnormal_cartilage_morphology0.71185026
108MP0004782_abnormal_surfactant_physiolog0.70709703
109MP0000428_abnormal_craniofacial_morphol0.68607073
110MP0002877_abnormal_melanocyte_morpholog0.67437093
111MP0001299_abnormal_eye_distance/0.67431197
112MP0008875_abnormal_xenobiotic_pharmacok0.64510833
113MP0003315_abnormal_perineum_morphology0.64082630
114MP0005623_abnormal_meninges_morphology0.63379609
115MP0005084_abnormal_gallbladder_morpholo0.63137296
116MP0005310_abnormal_salivary_gland0.62826088
117MP0000470_abnormal_stomach_morphology0.61779367
118MP0005379_endocrine/exocrine_gland_phen0.58949367
119MP0000538_abnormal_urinary_bladder0.57766694
120MP0005253_abnormal_eye_physiology0.57286514
121MP0005000_abnormal_immune_tolerance0.57069676
122MP0002420_abnormal_adaptive_immunity0.56671112
123MP0005503_abnormal_tendon_morphology0.56641051
124MP0000685_abnormal_immune_system0.55750301
125MP0005390_skeleton_phenotype0.55711215
126MP0001819_abnormal_immune_cell0.55221269
127MP0006035_abnormal_mitochondrial_morpho0.55158589
128MP0003890_abnormal_embryonic-extraembry0.54097685
129MP0001784_abnormal_fluid_regulation0.53837650
130MP0003252_abnormal_bile_duct0.53565226
131MP0002148_abnormal_hypersensitivity_rea0.53301594
132MP0003950_abnormal_plasma_membrane0.53167219
133MP0001984_abnormal_olfaction0.52477604
134MP0004742_abnormal_vestibular_system0.51972745
135MP0005367_renal/urinary_system_phenotyp0.50325977
136MP0000516_abnormal_urinary_system0.50325977
137MP0002095_abnormal_skin_pigmentation0.50061732
138MP0002697_abnormal_eye_size0.49671073
139MP0001186_pigmentation_phenotype0.49463787
140MP0002909_abnormal_adrenal_gland0.49186380
141MP0001177_atelectasis0.48704901
142MP0001873_stomach_inflammation0.48168939
143MP0002115_abnormal_skeleton_extremities0.46901825
144MP0000537_abnormal_urethra_morphology0.46544308
145MP0005395_other_phenotype0.46516011
146MP0005410_abnormal_fertilization0.46470671
147MP0000627_abnormal_mammary_gland0.46273144
148MP0005076_abnormal_cell_differentiation0.44552094
149MP0002109_abnormal_limb_morphology0.44023719
150MP0000432_abnormal_head_morphology0.43289287
151MP0003943_abnormal_hepatobiliary_system0.43172764
152MP0005174_abnormal_tail_pigmentation0.42246668
153MP0003935_abnormal_craniofacial_develop0.40699791
154MP0001853_heart_inflammation0.40255206
155MP0000613_abnormal_salivary_gland0.38957392
156MP0004885_abnormal_endolymph0.38338636
157MP0010155_abnormal_intestine_physiology0.37992416
158MP0005193_abnormal_anterior_eye0.37896114
159MP0002111_abnormal_tail_morphology0.37652047
160MP0003795_abnormal_bone_structure0.37563519
161MP0003638_abnormal_response/metabolism_0.36525050
162MP0000681_abnormal_thyroid_gland0.35906592

Predicted human phenotypes

RankGene SetZ-score
1Fragile nails (HP:0001808)8.15924947
2Hypotrichosis (HP:0001006)6.25448907
3Increased IgE level (HP:0003212)5.92805073
4Onycholysis (HP:0001806)5.91751931
5Plantar hyperkeratosis (HP:0007556)5.91625540
6Woolly hair (HP:0002224)5.39891566
7Milia (HP:0001056)5.12999182
8Alopecia of scalp (HP:0002293)4.68078349
9Right ventricular cardiomyopathy (HP:0011663)4.52434547
10Distal lower limb muscle weakness (HP:0009053)4.43456764
11Parakeratosis (HP:0001036)4.27222660
12Atrophic scars (HP:0001075)4.18540402
13Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.99683423
14Amyloidosis (HP:0011034)3.99551195
15Congenital ichthyosiform erythroderma (HP:0007431)3.98981511
16Down-sloping shoulders (HP:0200021)3.94427279
17Oral leukoplakia (HP:0002745)3.84056780
18Pili torti (HP:0003777)3.76482865
19Lip pit (HP:0100267)3.60692810
20Erythroderma (HP:0001019)3.60247510
21Abnormality of the axillary hair (HP:0100134)3.51607389
22Abnormality of secondary sexual hair (HP:0009888)3.51607389
23* Abnormal blistering of the skin (HP:0008066)3.46579912
24Reticulocytopenia (HP:0001896)3.44871211
25Concave nail (HP:0001598)3.44195608
26Double outlet right ventricle (HP:0001719)3.42041495
27Congenital malformation of the right heart (HP:0011723)3.42041495
28Palmoplantar hyperkeratosis (HP:0000972)3.39474435
29Elevated circulating parathyroid hormone (PTH) level (HP:0003165)3.38812461
30Abnormality of cells of the erythroid lineage (HP:0012130)3.37816286
31Sparse scalp hair (HP:0002209)3.35963941
32Mixed hearing impairment (HP:0000410)3.35145401
33Conjunctival hamartoma (HP:0100780)3.32483290
34Sparse eyelashes (HP:0000653)3.26566789
35Natal tooth (HP:0000695)3.24663420
36Palmar hyperkeratosis (HP:0010765)3.22203915
37Hyporeflexia of lower limbs (HP:0002600)3.17384171
38Abnormality of nail color (HP:0100643)3.07071759
39Furrowed tongue (HP:0000221)3.02494143
40Palmoplantar keratoderma (HP:0000982)3.01843306
41Hypodontia (HP:0000668)2.98223819
42Nail dystrophy (HP:0008404)2.94608110
43Popliteal pterygium (HP:0009756)2.89408130
44Sex reversal (HP:0012245)2.86606886
45Abnormal sex determination (HP:0012244)2.86606886
46Acanthosis nigricans (HP:0000956)2.86421712
47Advanced eruption of teeth (HP:0006288)2.70189954
48* Erythema (HP:0010783)2.67489030
49Abnormal hair laboratory examination (HP:0003328)2.67316841
50Upper limb muscle weakness (HP:0003484)2.62748958
51Abnormality of B cell number (HP:0010975)2.62389927
52Pruritus (HP:0000989)2.62190690
53Abnormal number of erythroid precursors (HP:0012131)2.61489455
54Ridged nail (HP:0001807)2.60539850
55Absent eyelashes (HP:0000561)2.59871298
56Congenital, generalized hypertrichosis (HP:0004540)2.56762447
57Neonatal short-limb short stature (HP:0008921)2.54663990
58B lymphocytopenia (HP:0010976)2.52157677
59Prostate neoplasm (HP:0100787)2.46237456
60Aplasia cutis congenita (HP:0001057)2.44919312
61Follicular hyperkeratosis (HP:0007502)2.43389428
62Ectropion (HP:0000656)2.42927529
63Abnormality of hair growth rate (HP:0011363)2.42719752
64Slow-growing hair (HP:0002217)2.42719752
65Absent hair (HP:0002298)2.42565717
66Abnormal hemoglobin (HP:0011902)2.41030873
67Hamartoma of the eye (HP:0010568)2.40750514
68Hypoplasia of dental enamel (HP:0006297)2.33799975
69Pterygium (HP:0001059)2.32474287
70Curly hair (HP:0002212)2.31131574
71Thick nail (HP:0001805)2.30544735
72Bronchomalacia (HP:0002780)2.29407820
73Fatigable weakness (HP:0003473)2.27823295
74Abnormality of the neuromuscular junction (HP:0003398)2.27823295
75Oligodontia (HP:0000677)2.27297102
76Corneal erosion (HP:0200020)2.27176999
77Duplicated collecting system (HP:0000081)2.24533383
78Hypohidrosis (HP:0000966)2.22196561
79Amelogenesis imperfecta (HP:0000705)2.21699330
80Dehydration (HP:0001944)2.20263446
81Gangrene (HP:0100758)2.20128127
82Xerostomia (HP:0000217)2.19231654
83Ulnar claw (HP:0001178)2.18873736
84Dry hair (HP:0011359)2.18270568
85Blepharitis (HP:0000498)2.17222246
86Hypoplastic labia majora (HP:0000059)2.17002993
87Type I diabetes mellitus (HP:0100651)2.16871230
88Oligodactyly (HP:0012165)2.15480497
89Severe Myopia (HP:0011003)2.13632388
90Bifid scrotum (HP:0000048)2.13574411
91Areflexia of lower limbs (HP:0002522)2.12752539
92Pancreatic cysts (HP:0001737)2.09030368
93Abnormality of the renal collecting system (HP:0004742)2.06965483
94Recurrent corneal erosions (HP:0000495)2.06689193
95Abnormality of calcium-phosphate metabolism (HP:0100530)2.06211360
96Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.05682073
97Clubbing of toes (HP:0100760)2.04195661
9811 pairs of ribs (HP:0000878)2.02383153
99Macrocytic anemia (HP:0001972)2.00144076
100Hyperhidrosis (HP:0000975)1.97445847
101Pallor (HP:0000980)1.96998914
102Chin dimple (HP:0010751)1.96831112
103Brittle hair (HP:0002299)1.95722696
104Esophageal atresia (HP:0002032)1.95449571
105Absent eyebrow (HP:0002223)1.94773614
106Abnormality of the labia majora (HP:0012881)1.94702643
107Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.94465501
108Abnormality of the parathyroid morphology (HP:0011766)1.92497309
109Pustule (HP:0200039)1.92165071
110Albinism (HP:0001022)1.90821293
111Recurrent sinusitis (HP:0011108)1.90744232
112Aplasia involving bones of the extremities (HP:0009825)1.90288696
113Aplasia involving bones of the upper limbs (HP:0009823)1.90288696
114Aplasia of the phalanges of the hand (HP:0009802)1.90288696
115Unilateral renal agenesis (HP:0000122)1.83938427
116Stomach cancer (HP:0012126)1.83534175
117Oligodactyly (hands) (HP:0001180)1.83333648
118Hypoparathyroidism (HP:0000829)1.83293720
119Abnormality of the salivary glands (HP:0010286)1.82166496
120Abnormality of small intestinal villus morphology (HP:0011472)1.80098878
121Villous atrophy (HP:0011473)1.80098878
122Abnormality of the prostate (HP:0008775)1.80093295
123Congenital stationary night blindness (HP:0007642)1.79941173
124Weak cry (HP:0001612)1.79803741
125Anhidrosis (HP:0000970)1.79583380
126Ventricular tachycardia (HP:0004756)1.79262807
127Fair hair (HP:0002286)1.79240923
128Conical tooth (HP:0000698)1.78839886
129Tibial bowing (HP:0002982)1.78621570
130Abnormality of the 2nd finger (HP:0004100)1.77364715
131Paralysis (HP:0003470)1.76660962
132IgA deficiency (HP:0002720)1.75055966
133Dry skin (HP:0000958)1.70889193
134Congenital sensorineural hearing impairment (HP:0008527)1.70764313
135Gastrointestinal stroma tumor (HP:0100723)1.70743979
136Pendular nystagmus (HP:0012043)1.70722639
137Gaze-evoked nystagmus (HP:0000640)1.67022053
138Abnormality of incisor morphology (HP:0011063)1.64532203
139Tubular atrophy (HP:0000092)1.62841049
140Hypergammaglobulinemia (HP:0010702)1.61819785
141Lack of skin elasticity (HP:0100679)1.60327149
142Abnormality of the renal cortex (HP:0011035)1.58311472
143Nephronophthisis (HP:0000090)1.55812992
144Urticaria (HP:0001025)1.55718214
145Abnormality of the renal medulla (HP:0100957)1.54781235
146IgG deficiency (HP:0004315)1.54762854
147Widely spaced teeth (HP:0000687)1.53633742
148Abnormality of the preputium (HP:0100587)1.53031114
149Fine hair (HP:0002213)1.51556685
150Decreased circulating renin level (HP:0003351)1.47961641
151Attenuation of retinal blood vessels (HP:0007843)1.46272198
152True hermaphroditism (HP:0010459)1.46241532
153Hypoplastic iliac wings (HP:0002866)1.45831093
154Hyperventilation (HP:0002883)1.45816738
155Abnormality of macular pigmentation (HP:0008002)1.45574149
156Aplasia/Hypoplasia of the uvula (HP:0010293)1.45549837
157Keratoconjunctivitis (HP:0001096)1.44861707
158Abnormality of T cell physiology (HP:0011840)1.44434722
159Amniotic constriction ring (HP:0009775)1.44423794
160Abnormality of placental membranes (HP:0011409)1.44423794
161Pancreatic fibrosis (HP:0100732)1.41306201

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK38L5.36454586
2MST1R4.92291611
3FRK4.85430732
4MAPKAPK34.72247786
5EPHB24.05995041
6ERN13.10229157
7RPS6KB22.76345623
8EIF2AK32.58747071
9MAP3K32.56088939
10BCR2.52047777
11TAF12.43336983
12MAP4K22.36723249
13STK242.33011383
14FER2.26088898
15INSRR2.23278296
16MST42.17396472
17ERBB32.14655623
18ADRBK22.11149967
19CSNK1G22.10098362
20ZAK2.08871537
21MAP3K21.98365463
22KIT1.92171761
23TNIK1.90402184
24ACVR1B1.80212880
25BMPR21.74973838
26TAOK31.67995555
27FLT31.67121768
28VRK21.61369874
29GRK11.60869547
30LRRK21.56230114
31LATS11.54146619
32MAPKAPK51.52269730
33NLK1.49034040
34MAP3K131.47397038
35DYRK1B1.46997887
36STK31.44407827
37PIM21.40490618
38PRKD11.40334758
39BMPR1B1.39106890
40HIPK21.38875079
41DYRK31.37181110
42RIPK41.36809624
43MAP3K141.30840310
44VRK11.24275378
45TRPM71.22283225
46BCKDK1.21436202
47MAP3K91.19872593
48WNK31.16514437
49PTK61.16287219
50CASK1.13724176
51TLK11.10883805
52EPHB11.02767897
53MET1.02467501
54MAPK131.01593429
55MKNK20.98429185
56MAP2K60.98114585
57PBK0.97481195
58IKBKB0.95599228
59PRKCQ0.94576688
60OXSR10.91404906
61ARAF0.90588698
62IRAK40.90145086
63BTK0.89770830
64MELK0.89295833
65EPHA30.88525354
66PRKCE0.86036041
67EPHA40.85544968
68PINK10.82457705
69PRKAA20.82251322
70MAP3K60.81713096
71ROCK10.81182221
72STK390.80142511
73CAMKK10.79007618
74FGFR20.78995386
75FGFR30.75753363
76NTRK20.75474881
77PTK2B0.75007698
78PRKCI0.74235249
79PKN10.74048313
80PAK30.73626704
81SIK30.72454763
82IKBKE0.72239312
83CDK60.71394293
84MAP2K20.71325225
85CSF1R0.70215912
86FGFR40.69810052
87LATS20.66802665
88SIK10.66690233
89MUSK0.66367596
90FGFR10.65525243
91TGFBR10.64801151
92YES10.63106865
93TBK10.62792281
94PRKD20.62673509
95TEC0.62604452
96MAP2K10.62198968
97TNK20.62034996
98PLK20.61619716
99MAPKAPK20.61113747
100GRK50.59865974
101CSNK1A1L0.58124294
102WNK10.55760446
103MAPK70.55395233
104BLK0.51829792
105IRAK10.51326804
106STK380.49938688
107GSK3A0.49599970
108EIF2AK20.49316418
109WNK40.49282593
110MAPK30.48619598
111MAP3K40.48364877
112CHUK0.48206474
113ILK0.47770313
114BMX0.47664995
115NTRK10.45823924
116RPS6KL10.45657916
117RPS6KC10.45657916
118EEF2K0.45362162
119CSNK1G10.45091194
120NUAK10.43736294
121TRIM280.43041044
122PIK3CG0.42298609
123RPS6KA20.41860196
124RPS6KA60.41550820
125EPHA20.41510295
126ADRBK10.41508006
127MARK30.41319762
128HCK0.41311312
129ABL10.40487055
130SMG10.39676399
131EIF2AK10.39499448
132OBSCN0.39419571
133PRKACA0.38796603
134LYN0.38481926
135MAPK150.38181072
136MAP2K30.37636141
137SIK20.37274263
138BRSK20.36761082
139PIK3CA0.36197903
140MAPK120.36048449
141DYRK1A0.34746693
142CSNK1D0.34512792
143MAPK110.32549417
144STK100.32212474
145MATK0.30759832
146MAPK40.30612457
147PRKCH0.30275736
148RPS6KA10.30185701
149IRAK20.29649613
150LCK0.29538778
151CSNK1G30.29307589
152TRIB30.27808702
153PRKCD0.27431334
154SYK0.27315351
155JAK30.26999299
156DAPK20.26330221
157CCNB10.25337989
158ITK0.24775243
159NEK10.24328724

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.45650756
2Intestinal immune network for IgA production_Homo sapiens_hsa046723.58663053
3Autoimmune thyroid disease_Homo sapiens_hsa053203.12944109
4Cyanoamino acid metabolism_Homo sapiens_hsa004602.66250685
5Asthma_Homo sapiens_hsa053102.65552072
6Sphingolipid metabolism_Homo sapiens_hsa006002.56130085
7Allograft rejection_Homo sapiens_hsa053302.34151434
8Primary immunodeficiency_Homo sapiens_hsa053402.28760522
9Phototransduction_Homo sapiens_hsa047442.25264031
10Basal cell carcinoma_Homo sapiens_hsa052172.22430142
11Nitrogen metabolism_Homo sapiens_hsa009102.06584772
12Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.98184628
13Graft-versus-host disease_Homo sapiens_hsa053321.96414428
14Tryptophan metabolism_Homo sapiens_hsa003801.80512471
15Type I diabetes mellitus_Homo sapiens_hsa049401.79200950
16Regulation of autophagy_Homo sapiens_hsa041401.76891057
17Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.73656740
18Histidine metabolism_Homo sapiens_hsa003401.69483281
19Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.66173780
20Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.64196556
21Homologous recombination_Homo sapiens_hsa034401.62010395
22Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.57761528
23Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.57527956
24Ovarian steroidogenesis_Homo sapiens_hsa049131.53540554
25Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.50794332
26Phenylalanine metabolism_Homo sapiens_hsa003601.49608984
27Non-homologous end-joining_Homo sapiens_hsa034501.49383145
28Hedgehog signaling pathway_Homo sapiens_hsa043401.49143976
29ECM-receptor interaction_Homo sapiens_hsa045121.49111605
30Retinol metabolism_Homo sapiens_hsa008301.47955353
31Axon guidance_Homo sapiens_hsa043601.46238846
32Linoleic acid metabolism_Homo sapiens_hsa005911.43202607
33Melanogenesis_Homo sapiens_hsa049161.42889568
34Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.41071170
35Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.40738307
36SNARE interactions in vesicular transport_Homo sapiens_hsa041301.40260328
37Butanoate metabolism_Homo sapiens_hsa006501.39491969
38Chemical carcinogenesis_Homo sapiens_hsa052041.38680654
39alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.38022838
40RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.37797610
41Tight junction_Homo sapiens_hsa045301.36248285
42Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.32412543
43Staphylococcus aureus infection_Homo sapiens_hsa051501.31470058
44Hepatitis C_Homo sapiens_hsa051601.29316665
45Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.26856637
46Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.26670263
47Circadian rhythm_Homo sapiens_hsa047101.22580669
48Systemic lupus erythematosus_Homo sapiens_hsa053221.22331540
49Protein digestion and absorption_Homo sapiens_hsa049741.18191893
50Tyrosine metabolism_Homo sapiens_hsa003501.17970178
51Leukocyte transendothelial migration_Homo sapiens_hsa046701.15767366
52Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.13174246
53Amoebiasis_Homo sapiens_hsa051461.11964385
54Fanconi anemia pathway_Homo sapiens_hsa034601.11936070
55Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.11399332
56Arachidonic acid metabolism_Homo sapiens_hsa005901.11124856
57Hippo signaling pathway_Homo sapiens_hsa043901.08520379
58Basal transcription factors_Homo sapiens_hsa030221.08105088
59Fatty acid elongation_Homo sapiens_hsa000621.06961869
60Glycerophospholipid metabolism_Homo sapiens_hsa005641.06700999
61Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.05167386
62Tuberculosis_Homo sapiens_hsa051521.03087484
63Maturity onset diabetes of the young_Homo sapiens_hsa049501.00687198
64Selenocompound metabolism_Homo sapiens_hsa004501.00514154
65Sphingolipid signaling pathway_Homo sapiens_hsa040711.00249740
66Protein export_Homo sapiens_hsa030600.99188315
67Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.98578203
68Toll-like receptor signaling pathway_Homo sapiens_hsa046200.96524666
69VEGF signaling pathway_Homo sapiens_hsa043700.96140992
70Gastric acid secretion_Homo sapiens_hsa049710.95967556
71ABC transporters_Homo sapiens_hsa020100.94884739
72Dorso-ventral axis formation_Homo sapiens_hsa043200.93060295
73Melanoma_Homo sapiens_hsa052180.92901354
74Propanoate metabolism_Homo sapiens_hsa006400.92528753
75Rheumatoid arthritis_Homo sapiens_hsa053230.91560782
76Renin secretion_Homo sapiens_hsa049240.89281894
77Proteoglycans in cancer_Homo sapiens_hsa052050.88348755
78Adherens junction_Homo sapiens_hsa045200.87509654
79Glycerolipid metabolism_Homo sapiens_hsa005610.86312629
80Wnt signaling pathway_Homo sapiens_hsa043100.83314345
81Salivary secretion_Homo sapiens_hsa049700.82529635
82Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.79577441
83Platelet activation_Homo sapiens_hsa046110.79138876
84Jak-STAT signaling pathway_Homo sapiens_hsa046300.76797877
85Ras signaling pathway_Homo sapiens_hsa040140.76523900
86Rap1 signaling pathway_Homo sapiens_hsa040150.76422012
87Proteasome_Homo sapiens_hsa030500.75158087
88Lysine degradation_Homo sapiens_hsa003100.72835300
89Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.72275935
90Calcium signaling pathway_Homo sapiens_hsa040200.71349536
91Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.71244458
92Long-term depression_Homo sapiens_hsa047300.70204989
93Vascular smooth muscle contraction_Homo sapiens_hsa042700.69872409
94Taste transduction_Homo sapiens_hsa047420.69790622
95Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.68447280
96GnRH signaling pathway_Homo sapiens_hsa049120.66760815
97TGF-beta signaling pathway_Homo sapiens_hsa043500.66004387
98Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.63493269
99Amphetamine addiction_Homo sapiens_hsa050310.63290680
100Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.63071553
101cAMP signaling pathway_Homo sapiens_hsa040240.62968559
102Collecting duct acid secretion_Homo sapiens_hsa049660.62543556
103Bladder cancer_Homo sapiens_hsa052190.61234574
104PI3K-Akt signaling pathway_Homo sapiens_hsa041510.60981878
105Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.60786870
106Viral myocarditis_Homo sapiens_hsa054160.60659440
107NOD-like receptor signaling pathway_Homo sapiens_hsa046210.60055041
108Olfactory transduction_Homo sapiens_hsa047400.59956865
109TNF signaling pathway_Homo sapiens_hsa046680.58471765
110ErbB signaling pathway_Homo sapiens_hsa040120.57864988
111Transcriptional misregulation in cancer_Homo sapiens_hsa052020.57007415
112Ether lipid metabolism_Homo sapiens_hsa005650.56348133
113Pertussis_Homo sapiens_hsa051330.54614425
114Osteoclast differentiation_Homo sapiens_hsa043800.53547752
115Salmonella infection_Homo sapiens_hsa051320.53413967
116Nicotine addiction_Homo sapiens_hsa050330.52047588
117Oxytocin signaling pathway_Homo sapiens_hsa049210.51348318
118Aldosterone synthesis and secretion_Homo sapiens_hsa049250.51099565
119AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.50016360
120Long-term potentiation_Homo sapiens_hsa047200.49646656
121Mineral absorption_Homo sapiens_hsa049780.49377838
122Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.49057791
123Antigen processing and presentation_Homo sapiens_hsa046120.48330001
124One carbon pool by folate_Homo sapiens_hsa006700.48183039
125Toxoplasmosis_Homo sapiens_hsa051450.48174446
126Estrogen signaling pathway_Homo sapiens_hsa049150.47212645
127Serotonergic synapse_Homo sapiens_hsa047260.46928839
128Hematopoietic cell lineage_Homo sapiens_hsa046400.46748545
129Steroid hormone biosynthesis_Homo sapiens_hsa001400.46585062
130Glioma_Homo sapiens_hsa052140.46212658
131Pentose and glucuronate interconversions_Homo sapiens_hsa000400.45853190
132Pathways in cancer_Homo sapiens_hsa052000.45454023
133Peroxisome_Homo sapiens_hsa041460.44199396
134Influenza A_Homo sapiens_hsa051640.44019637
135Herpes simplex infection_Homo sapiens_hsa051680.43468262
136p53 signaling pathway_Homo sapiens_hsa041150.43148137
137Phosphatidylinositol signaling system_Homo sapiens_hsa040700.43144599
138Pancreatic secretion_Homo sapiens_hsa049720.43049583
139Small cell lung cancer_Homo sapiens_hsa052220.42963754
140Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.42700798
141T cell receptor signaling pathway_Homo sapiens_hsa046600.41486037
142Circadian entrainment_Homo sapiens_hsa047130.40740238
143Acute myeloid leukemia_Homo sapiens_hsa052210.39758070
144Prolactin signaling pathway_Homo sapiens_hsa049170.38847692
145Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.38717889
146Focal adhesion_Homo sapiens_hsa045100.38479340
147NF-kappa B signaling pathway_Homo sapiens_hsa040640.38003513
148Glutamatergic synapse_Homo sapiens_hsa047240.37245479
149Fat digestion and absorption_Homo sapiens_hsa049750.37202003
150Steroid biosynthesis_Homo sapiens_hsa001000.33367047
151Vitamin digestion and absorption_Homo sapiens_hsa049770.31205694
152Caffeine metabolism_Homo sapiens_hsa002320.29059875
153Epstein-Barr virus infection_Homo sapiens_hsa051690.27366774
154RNA polymerase_Homo sapiens_hsa030200.26127366
155Leishmaniasis_Homo sapiens_hsa051400.25899040
156Primary bile acid biosynthesis_Homo sapiens_hsa001200.24787642
157beta-Alanine metabolism_Homo sapiens_hsa004100.22910005
158Alcoholism_Homo sapiens_hsa050340.22102346

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