TGM3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Transglutaminases are enzymes that catalyze the crosslinking of proteins by epsilon-gamma glutamyl lysine isopeptide bonds. While the primary structure of transglutaminases is not conserved, they all have the same amino acid sequence at their active sites and their activity is calcium-dependent. The protein encoded by this gene consists of two polypeptide chains activated from a single precursor protein by proteolysis. The encoded protein is involved the later stages of cell envelope formation in the epidermis and hair follicle. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1molting cycle (GO:0042303)8.07228003
2hair cycle (GO:0042633)8.07228003
3transepithelial transport (GO:0070633)7.19425605
4bundle of His cell to Purkinje myocyte communication (GO:0086069)7.07735423
5desmosome organization (GO:0002934)6.97391159
6long-chain fatty acid biosynthetic process (GO:0042759)6.52882636
7negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)6.30420562
8hemidesmosome assembly (GO:0031581)6.09914993
9sulfate transmembrane transport (GO:1902358)5.98287073
10* peptide cross-linking (GO:0018149)5.95972420
11regulation of water loss via skin (GO:0033561)5.80349371
12establishment of skin barrier (GO:0061436)5.77962967
13cell wall macromolecule catabolic process (GO:0016998)5.59793862
14cell wall macromolecule metabolic process (GO:0044036)5.59793862
15linoleic acid metabolic process (GO:0043651)5.41528935
16UDP-N-acetylglucosamine metabolic process (GO:0006047)5.22636145
17sulfate transport (GO:0008272)4.96690046
18establishment of planar polarity (GO:0001736)4.91610056
19establishment of tissue polarity (GO:0007164)4.91610056
20intestinal epithelial cell development (GO:0060576)4.88892508
21* keratinocyte differentiation (GO:0030216)4.88054835
22regulation of natural killer cell differentiation (GO:0032823)4.86995606
23O-glycan processing (GO:0016266)4.83508038
24negative regulation of interferon-gamma production (GO:0032689)4.83253541
25prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060524.75483543
26gap junction assembly (GO:0016264)4.74324004
27regulation of keratinocyte differentiation (GO:0045616)4.68910384
28intermediate filament organization (GO:0045109)4.68272012
29response to phenylpropanoid (GO:0080184)4.66642926
30regulation of toll-like receptor 4 signaling pathway (GO:0034143)4.65220914
31apical protein localization (GO:0045176)4.64923527
32multicellular organismal water homeostasis (GO:0050891)4.63423675
33maintenance of gastrointestinal epithelium (GO:0030277)4.55161288
34sequestering of metal ion (GO:0051238)4.51029089
35eyelid development in camera-type eye (GO:0061029)4.48007585
36renal system process involved in regulation of blood volume (GO:0001977)4.43354277
37positive regulation of monocyte chemotaxis (GO:0090026)4.41481046
38negative regulation of interleukin-17 production (GO:0032700)4.30850588
39negative regulation of keratinocyte proliferation (GO:0010839)4.18549719
40branching involved in prostate gland morphogenesis (GO:0060442)4.18503356
41detection of external biotic stimulus (GO:0098581)4.10756544
42hair cell differentiation (GO:0035315)4.09505217
43planar cell polarity pathway involved in neural tube closure (GO:0090179)4.02048193
44phosphatidylserine acyl-chain remodeling (GO:0036150)3.96206807
45L-fucose catabolic process (GO:0042355)3.95646003
46fucose catabolic process (GO:0019317)3.95646003
47L-fucose metabolic process (GO:0042354)3.95646003
48water homeostasis (GO:0030104)3.92143173
49* epidermal cell differentiation (GO:0009913)3.87987078
50epithelial structure maintenance (GO:0010669)3.86714094
51positive regulation of epidermal cell differentiation (GO:0045606)3.86571896
52regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.82887125
53phosphatidylinositol acyl-chain remodeling (GO:0036149)3.79700430
54epithelium development (GO:0060429)3.75437273
55virion attachment to host cell (GO:0019062)3.74472000
56adhesion of symbiont to host cell (GO:0044650)3.74472000
57* epithelial cell differentiation (GO:0030855)3.73994012
58primary alcohol catabolic process (GO:0034310)3.72936786
59keratinocyte development (GO:0003334)3.66581527
60skeletal muscle adaptation (GO:0043501)3.66058972
613-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)3.65293609
62purine ribonucleoside bisphosphate metabolic process (GO:0034035)3.65293609
63membrane raft organization (GO:0031579)3.63967456
64leukocyte aggregation (GO:0070486)3.60295657
65citrulline biosynthetic process (GO:0019240)3.57992198
66regulation of ruffle assembly (GO:1900027)3.54945411
67detection of biotic stimulus (GO:0009595)3.51614829
68asymmetric protein localization (GO:0008105)3.49894138
69positive regulation of epidermis development (GO:0045684)3.47218068
70sperm capacitation (GO:0048240)3.46720749
71regulation of epidermal cell differentiation (GO:0045604)3.46686181
72epidermis development (GO:0008544)3.46319931
73bicarbonate transport (GO:0015701)3.44982841
74skin morphogenesis (GO:0043589)3.43965166
75striated muscle atrophy (GO:0014891)3.41525924
76regulation of monocyte chemotaxis (GO:0090025)3.40675807
77response to vitamin A (GO:0033189)3.39405900
78phosphatidylethanolamine acyl-chain remodeling (GO:0036152)3.36396651
79diol metabolic process (GO:0034311)3.35054970
80localization within membrane (GO:0051668)3.32790384
81renal system process involved in regulation of systemic arterial blood pressure (GO:0003071)3.28669395
82positive regulation of actin filament depolymerization (GO:0030836)3.28260154
83pyrimidine-containing compound transmembrane transport (GO:0072531)3.27148562
84negative regulation of bone mineralization (GO:0030502)3.26162535
85regulation of epidermis development (GO:0045682)3.25491071
86regulation of chemokine secretion (GO:0090196)3.22777880
87ventricular cardiac muscle cell action potential (GO:0086005)3.21480482
88lipoxygenase pathway (GO:0019372)3.20781300
89defense response to fungus (GO:0050832)3.20696712
90leukocyte migration involved in inflammatory response (GO:0002523)3.19197247
91negative regulation of toll-like receptor signaling pathway (GO:0034122)3.18069861
92regulation of skeletal muscle contraction (GO:0014819)3.17382114
93regulation of neuron projection regeneration (GO:0070570)3.15082075
94regulation of axon regeneration (GO:0048679)3.15082075
95thrombin receptor signaling pathway (GO:0070493)3.13601003
96glucocorticoid biosynthetic process (GO:0006704)3.13529592
97phosphatidylglycerol acyl-chain remodeling (GO:0036148)3.11498444
98sphingosine metabolic process (GO:0006670)3.10779058
99negative regulation of glycogen biosynthetic process (GO:0045719)3.10266249
100cardiac conduction (GO:0061337)3.09922873
101regulation of T cell migration (GO:2000404)3.07650183
102actin filament depolymerization (GO:0030042)3.06115076
103muscle atrophy (GO:0014889)3.03552464
104protein O-linked glycosylation (GO:0006493)3.02199776
105keratan sulfate biosynthetic process (GO:0018146)3.02109153
106adhesion of symbiont to host (GO:0044406)3.01931775
107intermediate filament cytoskeleton organization (GO:0045104)2.98426970
108epithelial cell-cell adhesion (GO:0090136)2.98354298
109phosphatidylcholine acyl-chain remodeling (GO:0036151)2.96484419
110sphingoid metabolic process (GO:0046519)2.96381734
111sulfation (GO:0051923)2.94095868
112hepatocyte apoptotic process (GO:0097284)2.92742935
113negative regulation of biomineral tissue development (GO:0070168)2.92003940
114regulation of heart rate by cardiac conduction (GO:0086091)2.89200424
115sialylation (GO:0097503)2.87880556
116keratinocyte proliferation (GO:0043616)2.87159840
117positive regulation of keratinocyte differentiation (GO:0045618)2.86121993
118nucleotide-sugar biosynthetic process (GO:0009226)2.84989652
119intermediate filament-based process (GO:0045103)2.83443279
120positive regulation of Cdc42 GTPase activity (GO:0043089)2.82437698
121chronic inflammatory response (GO:0002544)2.81484729
122regulation of interleukin-17 production (GO:0032660)2.81225780
123regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.80064795
124cell communication involved in cardiac conduction (GO:0086065)2.79430251
125regulation of T cell chemotaxis (GO:0010819)2.78260283
126positive regulation of T cell chemotaxis (GO:0010820)2.78260283
127negative regulation of cell-cell adhesion (GO:0022408)2.78091489
128skeletal muscle contraction (GO:0003009)2.77337098
129regulation of natural killer cell activation (GO:0032814)2.76496304
130sulfur compound transport (GO:0072348)2.76095067
131positive regulation of granulocyte chemotaxis (GO:0071624)2.75640209
132potassium ion homeostasis (GO:0055075)2.73969544
133hypotonic response (GO:0006971)2.73553684
134lipopolysaccharide biosynthetic process (GO:0009103)2.73502117
135superoxide anion generation (GO:0042554)2.72577074
136regulation of pseudopodium assembly (GO:0031272)2.72257628
137regulation of pH (GO:0006885)2.70934224
138negative regulation of response to cytokine stimulus (GO:0060761)2.69602872
139ethanol metabolic process (GO:0006067)2.67339511
140detection of bacterium (GO:0016045)2.65001970
141negative regulation of cytokine-mediated signaling pathway (GO:0001960)2.64986185
142detection of other organism (GO:0098543)2.62417989
143dendritic cell chemotaxis (GO:0002407)2.61944358
144ectoderm development (GO:0007398)2.60979224
145negative regulation of glycogen metabolic process (GO:0070874)2.60625075
146negative regulation of interleukin-6 production (GO:0032715)2.60113641
147nucleotide-sugar metabolic process (GO:0009225)2.59883048
148sulfur amino acid catabolic process (GO:0000098)2.59684146
149amyloid precursor protein catabolic process (GO:0042987)2.58174308
150ceramide biosynthetic process (GO:0046513)2.57438649
151epithelial cell maturation (GO:0002070)2.56092358
152antimicrobial humoral response (GO:0019730)2.55179744
153oligosaccharide biosynthetic process (GO:0009312)2.54287269
154membrane hyperpolarization (GO:0060081)2.53992315
155branching involved in labyrinthine layer morphogenesis (GO:0060670)2.53501753
156lipopolysaccharide metabolic process (GO:0008653)2.53151269
157regulation of mesenchymal cell apoptotic process (GO:2001053)2.52779525
158wound healing (GO:0042060)2.48582538
159epithelial cell differentiation involved in prostate gland development (GO:0060742)2.46737783
160response to UV-B (GO:0010224)2.44767210
161phosphatidylserine metabolic process (GO:0006658)2.42872554
162negative regulation of homotypic cell-cell adhesion (GO:0034111)2.39717018
163polyol transport (GO:0015791)2.37828042
164macrophage activation involved in immune response (GO:0002281)2.34670898
165one-carbon compound transport (GO:0019755)2.32807225
166regulation of type 2 immune response (GO:0002828)2.32604069
167negative regulation of peptidase activity (GO:0010466)2.30630687
168* keratinization (GO:0031424)12.1584711

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human9.24171966
2CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.46181826
3CDX2_20551321_ChIP-Seq_CACO-2_Human3.04618393
4CDX2_19796622_ChIP-Seq_MESCs_Mouse2.64335790
5TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.62901972
6ESR1_21235772_ChIP-Seq_MCF-7_Human2.58878128
7RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.56351187
8SOX2_20726797_ChIP-Seq_SW620_Human2.29210372
9TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.28863779
10SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.26273329
11ESR1_20079471_ChIP-ChIP_T-47D_Human2.09768324
12BP1_19119308_ChIP-ChIP_Hs578T_Human2.08274482
13SOX2_27498859_Chip-Seq_STOMACH_Mouse2.07961369
14ESR2_21235772_ChIP-Seq_MCF-7_Human1.99795956
15CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.97847022
16TRIM28_21343339_ChIP-Seq_HEK293_Human1.85115428
17ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.83427934
18P63_26484246_Chip-Seq_KERATINOCYTES_Human1.83001254
19GATA4_25053715_ChIP-Seq_YYC3_Human1.76378662
20TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.74361341
21KLF5_25053715_ChIP-Seq_YYC3_Human1.65046311
22GATA6_25053715_ChIP-Seq_YYC3_Human1.64674660
23SMC4_20622854_ChIP-Seq_HELA_Human1.59971735
24SMAD_19615063_ChIP-ChIP_OVARY_Human1.57699974
25SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.52902989
26SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.52902989
27RACK7_27058665_Chip-Seq_MCF-7_Human1.51651572
28ZNF217_24962896_ChIP-Seq_MCF-7_Human1.49981671
29RARG_19884340_ChIP-ChIP_MEFs_Mouse1.46896049
30FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.40037814
31RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.39784744
32KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.39588025
33RUNX1_27514584_Chip-Seq_MCF-7_Human1.39567130
34BCOR_27268052_Chip-Seq_Bcells_Human1.39291478
35STAT6_21828071_ChIP-Seq_BEAS2B_Human1.39048745
36STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.38661803
37FOXO3_23340844_ChIP-Seq_DLD1_Human1.36625244
38AHR_22903824_ChIP-Seq_MCF-7_Human1.35746264
39ELK3_25401928_ChIP-Seq_HUVEC_Human1.34822772
40UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.32938925
41TCF4_18268006_ChIP-ChIP_LS174T_Human1.32476324
42Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.29585094
43SOX9_24532713_ChIP-Seq_HFSC_Mouse1.27518881
44DNAJC2_21179169_ChIP-ChIP_NT2_Human1.26335118
45LXR_22292898_ChIP-Seq_THP-1_Human1.24214221
46ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.21512096
47PPAR_26484153_Chip-Seq_NCI-H1993_Human1.20510551
48KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.20326685
49* VDR_22108803_ChIP-Seq_LS180_Human1.20089835
50P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.18405618
51IRF8_21731497_ChIP-ChIP_J774_Mouse1.18364384
52GATA2_21666600_ChIP-Seq_HMVEC_Human1.16130002
53GATA3_24758297_ChIP-Seq_MCF-7_Human1.14963419
54DROSHA_22980978_ChIP-Seq_HELA_Human1.12380839
55CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.12003632
56CJUN_26792858_Chip-Seq_BT549_Human1.10881456
57ARNT_22903824_ChIP-Seq_MCF-7_Human1.08805805
58ZNF263_19887448_ChIP-Seq_K562_Human1.07648316
59SA1_27219007_Chip-Seq_ERYTHROID_Human1.07307411
60SA1_27219007_Chip-Seq_Bcells_Human1.06836409
61PPARA_22158963_ChIP-Seq_LIVER_Mouse1.06310998
62THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.06292831
63NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.05583435
64BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.04843344
65YY1_22570637_ChIP-Seq_MALME-3M_Human1.04825521
66CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.04802483
67RXR_22108803_ChIP-Seq_LS180_Human1.03451110
68AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.02539800
69KDM2B_26808549_Chip-Seq_SUP-B15_Human1.02418979
70FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.00117146
71GATA1_19941826_ChIP-Seq_K562_Human0.99113652
72EGR1_19032775_ChIP-ChIP_M12_Human0.98848391
73* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.97729110
74TCF7_22412390_ChIP-Seq_EML_Mouse0.97439960
75SPI1_20517297_ChIP-Seq_HL60_Human0.97280357
76IKZF1_21737484_ChIP-ChIP_HCT116_Human0.96804192
77KDM2B_26808549_Chip-Seq_DND41_Human0.96055084
78SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.95030871
79PCGF2_27294783_Chip-Seq_NPCs_Mouse0.94336284
80FOXM1_26456572_ChIP-Seq_MCF-7_Human0.94184545
81KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.93593616
82KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.93593616
83KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.93593616
84MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.93454955
85* GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.93393418
86NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.92866774
87RXR_22158963_ChIP-Seq_LIVER_Mouse0.91462042
88PIAS1_25552417_ChIP-Seq_VCAP_Human0.90744148
89* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.90452134
90RBPJ_21746931_ChIP-Seq_IB4_Human0.89878003
91* ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.88859097
92GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.88535894
93CREB1_26743006_Chip-Seq_LNCaP_Human0.88493578
94TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.88334395
95FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.87612821
96PCGF2_27294783_Chip-Seq_ESCs_Mouse0.87110720
97P300_27058665_Chip-Seq_ZR-75-30cells_Human0.87022812
98CTCF_27219007_Chip-Seq_Bcells_Human0.86903695
99ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.86283463
100SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.85789587
101FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.85479417
102NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.84220886
103HIF1A_21447827_ChIP-Seq_MCF-7_Human0.84181336
104P68_20966046_ChIP-Seq_HELA_Human0.84095322
105VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.83953254
106NANOG_20526341_ChIP-Seq_ESCs_Human0.83837484
107SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.83628050
108JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.82556153
109TP63_22573176_ChIP-Seq_HFKS_Human0.82125501
110* BCAT_22108803_ChIP-Seq_LS180_Human0.81936869
111TP63_23658742_ChIP-Seq_EP156T_Human0.81874141
112VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.81722847
113KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.80571794
114RUNX_20019798_ChIP-Seq_JUKART_Human0.80488073
115* GATA2_19941826_ChIP-Seq_K562_Human0.80056973
116P300_27268052_Chip-Seq_Bcells_Human0.79306421
117PHF8_20622854_ChIP-Seq_HELA_Human0.79156559
118HTT_18923047_ChIP-ChIP_STHdh_Human0.78400672
119GATA6_21074721_ChIP-Seq_CACO-2_Human0.78097930
120* CTCF_20526341_ChIP-Seq_ESCs_Human0.77432160
121JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.76169281
122CDX2_22108803_ChIP-Seq_LS180_Human0.75452412
123PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.74240910
124E2F1_20622854_ChIP-Seq_HELA_Human0.74175888
125TP53_16413492_ChIP-PET_HCT116_Human0.73105325
126KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.71422601
127CEBPB_22108803_ChIP-Seq_LS180_Human0.71029590
128SMAD3_21741376_ChIP-Seq_HESCs_Human0.70954555
129ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.70313084
130BCL6_27268052_Chip-Seq_Bcells_Human0.69787398
131ATF3_27146783_Chip-Seq_COLON_Human0.67766998
132ERG_20517297_ChIP-Seq_VCAP_Human0.67714349
133BMI1_23680149_ChIP-Seq_NPCS_Mouse0.67634955
134TP53_18474530_ChIP-ChIP_U2OS_Human0.67383315
135PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.66674700
136PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.66332413

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010234_abnormal_vibrissa_follicle5.55628403
2MP0004043_abnormal_pH_regulation5.15160939
3MP0002796_impaired_skin_barrier5.08138117
4MP0000579_abnormal_nail_morphology3.70776830
5MP0005275_abnormal_skin_tensile3.70310232
6MP0004264_abnormal_extraembryonic_tissu3.59719724
7MP0003866_abnormal_defecation3.47113330
8MP0003705_abnormal_hypodermis_morpholog3.32534286
9MP0005501_abnormal_skin_physiology3.26046952
10MP0002098_abnormal_vibrissa_morphology2.97278979
11MP0005167_abnormal_blood-brain_barrier2.90393993
12MP0000467_abnormal_esophagus_morphology2.90217403
13MP0010678_abnormal_skin_adnexa2.86274103
14MP0000383_abnormal_hair_follicle2.69785319
15MP0004947_skin_inflammation2.63175121
16MP0000569_abnormal_digit_pigmentation2.52851746
17MP0004885_abnormal_endolymph2.50545195
18MP0003453_abnormal_keratinocyte_physiol2.45559896
19MP0002254_reproductive_system_inflammat2.45364129
20MP0001216_abnormal_epidermal_layer2.33654798
21MP0000762_abnormal_tongue_morphology2.27558653
22MP0000647_abnormal_sebaceous_gland2.21623665
23MP0005257_abnormal_intraocular_pressure2.20908869
24MP0002234_abnormal_pharynx_morphology2.19138208
25MP0010352_gastrointestinal_tract_polyps2.16908796
26MP0001663_abnormal_digestive_system2.10092807
27MP0010155_abnormal_intestine_physiology2.08220222
28MP0001873_stomach_inflammation2.01334694
29MP0000490_abnormal_crypts_of1.93764568
30MP0010771_integument_phenotype1.90454125
31MP0005381_digestive/alimentary_phenotyp1.87036743
32MP0000377_abnormal_hair_follicle1.84830169
33MP0002060_abnormal_skin_morphology1.83387943
34MP0001765_abnormal_ion_homeostasis1.81607239
35MP0000537_abnormal_urethra_morphology1.80996386
36MP0003566_abnormal_cell_adhesion1.72912057
37MP0000427_abnormal_hair_cycle1.57508562
38MP0000462_abnormal_digestive_system1.52196434
39MP0002277_abnormal_respiratory_mucosa1.50121951
40MP0000477_abnormal_intestine_morphology1.47907540
41MP0001851_eye_inflammation1.44533909
42MP0001849_ear_inflammation1.43473138
43MP0003941_abnormal_skin_development1.42694025
44MP0001243_abnormal_dermal_layer1.41264968
45MP0000470_abnormal_stomach_morphology1.37859293
46MP0005409_darkened_coat_color1.36707590
47MP0000538_abnormal_urinary_bladder1.35975131
48MP0002095_abnormal_skin_pigmentation1.35749827
49MP0001664_abnormal_digestion1.32243419
50MP0001191_abnormal_skin_condition1.30525112
51MP0000465_gastrointestinal_hemorrhage1.27154780
52MP0004782_abnormal_surfactant_physiolog1.25588430
53MP0009053_abnormal_anal_canal1.24421662
54MP0000678_abnormal_parathyroid_gland1.22164247
55MP0005310_abnormal_salivary_gland1.20795068
56MP0003868_abnormal_feces_composition1.20343199
57MP0003878_abnormal_ear_physiology1.14004048
58MP0005377_hearing/vestibular/ear_phenot1.14004048
59MP0003283_abnormal_digestive_organ1.10374834
60MP0000367_abnormal_coat/_hair1.09249446
61MP0009931_abnormal_skin_appearance1.08900206
62MP0003045_fibrosis1.03683623
63MP0009785_altered_susceptibility_to1.01114664
64MP0005166_decreased_susceptibility_to0.98890553
65MP0003300_gastrointestinal_ulcer0.98455557
66MP0002138_abnormal_hepatobiliary_system0.97615222
67MP0002148_abnormal_hypersensitivity_rea0.97406012
68MP0003011_delayed_dark_adaptation0.94577918
69MP0005451_abnormal_body_composition0.92678652
70MP0002822_catalepsy0.92165632
71MP0000516_abnormal_urinary_system0.91681522
72MP0005367_renal/urinary_system_phenotyp0.91681522
73MP0004484_altered_response_of0.91410489
74MP0003191_abnormal_cellular_cholesterol0.90806577
75MP0005187_abnormal_penis_morphology0.90455451
76MP0006054_spinal_hemorrhage0.89551772
77MP0005636_abnormal_mineral_homeostasis0.88108026
78MP0003315_abnormal_perineum_morphology0.86391117
79MP0008875_abnormal_xenobiotic_pharmacok0.85153379
80MP0001879_abnormal_lymphatic_vessel0.84248607
81MP0000371_diluted_coat_color0.81126306
82MP0005503_abnormal_tendon_morphology0.77971125
83MP0000566_synostosis0.77243546
84MP0004185_abnormal_adipocyte_glucose0.73683005
85MP0010030_abnormal_orbit_morphology0.73225389
86MP0000613_abnormal_salivary_gland0.73138142
87MP0001784_abnormal_fluid_regulation0.68971186
88MP0003436_decreased_susceptibility_to0.68872077
89MP0009379_abnormal_foot_pigmentation0.67986539
90MP0005025_abnormal_response_to0.67481846
91MP0002006_tumorigenesis0.67168692
92MP0003075_altered_response_to0.65881158
93MP0004381_abnormal_hair_follicle0.65429570
94MP0005666_abnormal_adipose_tissue0.64490851
95MP0005174_abnormal_tail_pigmentation0.63999062
96MP0001666_abnormal_nutrient_absorption0.63953223
97MP0005464_abnormal_platelet_physiology0.63869572
98MP0001188_hyperpigmentation0.62592047
99MP0002837_dystrophic_cardiac_calcinosis0.62137068
100MP0002075_abnormal_coat/hair_pigmentati0.60812036
101MP0001346_abnormal_lacrimal_gland0.58221902
102MP0003567_abnormal_fetal_cardiomyocyte0.57949719
103MP0009384_cardiac_valve_regurgitation0.54845453
104MP0001186_pigmentation_phenotype0.54384354
105MP0000685_abnormal_immune_system0.53286475
106MP0000751_myopathy0.52879568
107MP0009333_abnormal_splenocyte_physiolog0.52771793
108MP0000015_abnormal_ear_pigmentation0.52555029
109MP0002249_abnormal_larynx_morphology0.52324510
110MP0005023_abnormal_wound_healing0.51587565
111MP0002132_abnormal_respiratory_system0.48942103
112MP0001845_abnormal_inflammatory_respons0.48175277
113MP0008872_abnormal_physiological_respon0.48171008
114MP0009780_abnormal_chondrocyte_physiolo0.47424137
115MP0003724_increased_susceptibility_to0.46280773
116MP0001958_emphysema0.46118318
117MP0008004_abnormal_stomach_pH0.45639745
118MP0003638_abnormal_response/metabolism_0.45055698
119MP0003828_pulmonary_edema0.44343908
120MP0005375_adipose_tissue_phenotype0.44211114
121MP0001485_abnormal_pinna_reflex0.38716677
122MP0001533_abnormal_skeleton_physiology0.37696542
123MP0004019_abnormal_vitamin_homeostasis0.35736801
124MP0003763_abnormal_thymus_physiology0.32706036
125MP0002111_abnormal_tail_morphology0.32578195
126MP0005193_abnormal_anterior_eye0.31467921
127MP0001340_abnormal_eyelid_morphology0.30791566
128MP0003303_peritoneal_inflammation0.28584258
129MP0001790_abnormal_immune_system0.28525520
130MP0005387_immune_system_phenotype0.28525520
131MP0008789_abnormal_olfactory_epithelium0.26782788
132MP0009643_abnormal_urine_homeostasis0.24601972
133MP0002136_abnormal_kidney_physiology0.20984632
134MP0008260_abnormal_autophagy0.20361883
135MP0005388_respiratory_system_phenotype0.19094015
136MP0002133_abnormal_respiratory_system0.19094015
137MP0001800_abnormal_humoral_immune0.17414471
138MP0004197_abnormal_fetal_growth/weight/0.17406070
139MP0005390_skeleton_phenotype0.16593223
140MP0005164_abnormal_response_to0.15484838

Predicted human phenotypes

RankGene SetZ-score
1Erythroderma (HP:0001019)8.91312861
2Hyperactive renin-angiotensin system (HP:0000841)8.08072538
3Congenital nonbullous ichthyosiform erythroderma (HP:0007479)7.46900878
4Right ventricular cardiomyopathy (HP:0011663)6.68055712
5Metabolic alkalosis (HP:0200114)6.35106489
6Oral leukoplakia (HP:0002745)5.60677822
7Woolly hair (HP:0002224)5.25791451
8Abnormality of renin-angiotensin system (HP:0000847)4.97305910
9Lip pit (HP:0100267)4.86690615
10Pili torti (HP:0003777)4.82886362
11Onycholysis (HP:0001806)4.80310075
12Parakeratosis (HP:0001036)4.66197579
13Abnormality of secondary sexual hair (HP:0009888)4.60432661
14Abnormality of the axillary hair (HP:0100134)4.60432661
15Increased IgE level (HP:0003212)4.48128071
16Decreased circulating renin level (HP:0003351)4.41857684
17Abnormality of chloride homeostasis (HP:0011422)4.32085327
18Fragile nails (HP:0001808)4.20160931
19Plantar hyperkeratosis (HP:0007556)4.19750446
20Hypotrichosis (HP:0001006)4.18172427
21Ileus (HP:0002595)4.12680233
22Hyperaldosteronism (HP:0000859)3.84566562
23Hypohidrosis (HP:0000966)3.83023903
24Milia (HP:0001056)3.73170398
25Flat acetabular roof (HP:0003180)3.72301881
26Abnormality of the salivary glands (HP:0010286)3.66402719
27Absent eyelashes (HP:0000561)3.65956705
28Eczematoid dermatitis (HP:0000976)3.43540368
29Abnormal tarsal ossification (HP:0008369)3.39346500
30Palmoplantar hyperkeratosis (HP:0000972)3.32821225
31Absent hair (HP:0002298)3.31729946
32Sparse scalp hair (HP:0002209)3.18916687
33Congenital ichthyosiform erythroderma (HP:0007431)3.17593610
34Abdominal distention (HP:0003270)3.16716856
35Brittle hair (HP:0002299)3.16445123
36Abnormality of the 1st metacarpal (HP:0010009)3.14527975
37Curly hair (HP:0002212)3.14319210
38Abnormal hair laboratory examination (HP:0003328)3.10637397
39Urticaria (HP:0001025)3.10196158
40Nail dystrophy (HP:0008404)3.10086491
41Palmar hyperkeratosis (HP:0010765)3.09861340
42Absent phalangeal crease (HP:0006109)3.07145085
43Hyponatremia (HP:0002902)3.06707517
44Ureteral stenosis (HP:0000071)3.05619519
45Sparse eyelashes (HP:0000653)2.99086042
46Symphalangism affecting the phalanges of the hand (HP:0009773)2.93735887
47Myopathic facies (HP:0002058)2.92578285
48Furrowed tongue (HP:0000221)2.89861744
49Alkalosis (HP:0001948)2.89683117
50Abnormality of nail color (HP:0100643)2.89648817
51Hypokalemia (HP:0002900)2.87094265
52Abnormality of the distal phalanx of the thumb (HP:0009617)2.82451419
53Ureteral obstruction (HP:0006000)2.81452465
54Villous atrophy (HP:0011473)2.80212159
55Abnormality of small intestinal villus morphology (HP:0011472)2.80212159
56Mildly elevated creatine phosphokinase (HP:0008180)2.76503456
57Abnormality of placental membranes (HP:0011409)2.76104736
58Amniotic constriction ring (HP:0009775)2.76104736
59Thick nail (HP:0001805)2.73504926
60Distal arthrogryposis (HP:0005684)2.70647293
61Abnormality of potassium homeostasis (HP:0011042)2.69477512
62Atrophic scars (HP:0001075)2.55611474
63Neonatal short-limb short stature (HP:0008921)2.55488084
64Short 1st metacarpal (HP:0010034)2.55446287
65Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)2.55446287
66Dehydration (HP:0001944)2.54288062
67Abnormal foot bone ossification (HP:0010675)2.52102007
68Abnormal finger flexion creases (HP:0006143)2.51379304
69Lack of skin elasticity (HP:0100679)2.49180386
70Neck muscle weakness (HP:0000467)2.48837324
71Nasal polyposis (HP:0100582)2.48552905
72Distal lower limb muscle weakness (HP:0009053)2.48199932
73Alopecia of scalp (HP:0002293)2.48031986
74Ventricular tachycardia (HP:0004756)2.47379173
75Abnormality of sodium homeostasis (HP:0010931)2.46306129
76Acanthosis nigricans (HP:0000956)2.46299752
77Breech presentation (HP:0001623)2.46073292
78Autoamputation (HP:0001218)2.45931320
79Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.45137477
80Pustule (HP:0200039)2.44761246
81Hypergammaglobulinemia (HP:0010702)2.42763370
82Increased connective tissue (HP:0009025)2.42056361
83Abnormality of carpal bone ossification (HP:0006257)2.39109819
84Muscle fiber inclusion bodies (HP:0100299)2.37383316
85Gastrointestinal dysmotility (HP:0002579)2.36282337
86Exercise-induced myalgia (HP:0003738)2.31740302
87Round ear (HP:0100830)2.29798455
88Abnormality of hair growth rate (HP:0011363)2.28450682
89Slow-growing hair (HP:0002217)2.28450682
90Ulnar deviation of the wrist (HP:0003049)2.27941015
91Rimmed vacuoles (HP:0003805)2.26141090
92Ectropion (HP:0000656)2.25674118
93Amelogenesis imperfecta (HP:0000705)2.24850305
94Multifactorial inheritance (HP:0001426)2.24813166
95Nemaline bodies (HP:0003798)2.23918081
96Blepharitis (HP:0000498)2.23302697
97Conjunctival hamartoma (HP:0100780)2.22822097
98Recurrent bacterial skin infections (HP:0005406)2.19805999
99Hyperkalemia (HP:0002153)2.18934505
100Type 1 muscle fiber predominance (HP:0003803)2.16735748
101Short middle phalanx of finger (HP:0005819)2.16508806
102Keratoconjunctivitis sicca (HP:0001097)2.16450219
103Ulnar deviation of finger (HP:0009465)2.15053594
104Distal lower limb amyotrophy (HP:0008944)2.14611354
105Abnormality of the nasal mucosa (HP:0000433)2.14078032
106Hyporeflexia of lower limbs (HP:0002600)2.08840753
107Abnormal blistering of the skin (HP:0008066)2.08318204
108Abnormality of the neuromuscular junction (HP:0003398)2.06872308
109Fatigable weakness (HP:0003473)2.06872308
110Autoimmune thrombocytopenia (HP:0001973)2.04904968
111Short phalanx of the thumb (HP:0009660)2.03182627
112Flat capital femoral epiphysis (HP:0003370)2.02007987
113Palmoplantar keratoderma (HP:0000982)2.01335906
114Cupped ribs (HP:0000887)2.00955350
115Sepsis (HP:0100806)1.99166226
116Recurrent corneal erosions (HP:0000495)1.98739007
117Hypoplastic labia majora (HP:0000059)1.96829997
118Flattened epiphyses (HP:0003071)1.96755616
119Abnormality of the 2nd finger (HP:0004100)1.95879623
120Corneal erosion (HP:0200020)1.95727030
121Keratoconjunctivitis (HP:0001096)1.95409311
122Adrenal overactivity (HP:0002717)1.95329466
123Gangrene (HP:0100758)1.94678244
124Syncope (HP:0001279)1.94515728
125Progressive sensorineural hearing impairment (HP:0000408)1.92857133
126Autoimmune hemolytic anemia (HP:0001890)1.92612608
127Pruritus (HP:0000989)1.92279650
128Limb-girdle muscle atrophy (HP:0003797)1.92179577
129Erythema (HP:0010783)1.91708916
130Tetany (HP:0001281)1.90151012
131Popliteal pterygium (HP:0009756)1.88991359
132Melanocytic nevus (HP:0000995)1.88099067
133Abnormality of the gastric mucosa (HP:0004295)1.86968809
134Congenital sensorineural hearing impairment (HP:0008527)1.86087157
135Petechiae (HP:0000967)1.85190359
136Fine hair (HP:0002213)1.83770530
137Abnormality of the labia majora (HP:0012881)1.78015274
138Skin ulcer (HP:0200042)1.75410286
139Seborrheic dermatitis (HP:0001051)1.74647882
140Dry skin (HP:0000958)1.73307846
141Papilloma (HP:0012740)1.71856814
142Verrucae (HP:0200043)1.71856814
143Chronic bronchitis (HP:0004469)1.71798635
144Hyperhidrosis (HP:0000975)1.66107687
145Ridged nail (HP:0001807)1.64765611
146Follicular hyperkeratosis (HP:0007502)1.63759312
147Oligodontia (HP:0000677)1.59404341
148Hypoplastic toenails (HP:0001800)1.52868163
149Laryngomalacia (HP:0001601)1.50811032
150Cystic hygroma (HP:0000476)1.49483664
151Coarse hair (HP:0002208)1.46409257
152Anonychia (HP:0001798)1.44511641
153Hamartoma of the eye (HP:0010568)1.42373102
154Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.42363993
155Malnutrition (HP:0004395)1.41459778
156Xerostomia (HP:0000217)1.38937331
157Advanced eruption of teeth (HP:0006288)1.38789490
158Split foot (HP:0001839)1.36431811
159Skin pits (HP:0100276)1.33837850
160Preauricular skin tag (HP:0000384)1.29485455
161Generalized hyperpigmentation (HP:0007440)1.29193847
162Labial hypoplasia (HP:0000066)1.29125618
163Conical tooth (HP:0000698)1.27483770

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST1R4.73543161
2TTN3.56290520
3MST43.29838903
4MYLK3.07859359
5PIK3CG2.89586410
6EPHB22.77671086
7LMTK22.53310098
8FER2.40665377
9NME12.32899861
10FRK2.21335441
11PRKG22.21143519
12RIPK42.19281835
13TGFBR12.10339488
14RIPK12.06879757
15MAPKAPK32.02642511
16DDR21.99847602
17MAP2K21.96205429
18DMPK1.87632238
19MAP3K121.85644070
20TESK11.85274442
21TRIB31.77244265
22EPHB11.77013505
23EPHA31.68176849
24MARK21.67635814
25PIK3CA1.59456326
26KSR21.57530601
27MET1.50864865
28IRAK11.42953305
29MAP2K61.38822940
30PTK61.38798603
31MATK1.35645354
32MAP2K11.32114499
33MAP3K21.26597941
34MAP3K11.25364366
35WNK11.21560897
36MAP3K31.18244918
37EPHA21.18178497
38SGK2231.16934665
39SGK4941.16934665
40TRPM71.16276724
41TAOK11.14582476
42PRKD21.12068402
43MAP3K91.09710054
44EEF2K1.08441191
45MAP3K141.07893689
46CASK0.97571299
47TYRO30.94283602
48TIE10.94063796
49PAK40.92980706
50BMX0.91982646
51MAPK110.91160740
52ERBB30.91040543
53JAK30.90418367
54ZAP700.90332711
55CSK0.89062266
56MAP2K30.84989965
57ERN10.84185330
58MAP3K70.82970455
59GRK60.82618382
60PIM20.81528597
61HCK0.81197697
62MAP3K110.80799280
63SIK10.80162841
64IKBKE0.78070959
65PRKAA20.76148828
66IRAK20.74981750
67ERBB20.72695784
68FGFR40.71982509
69STK100.71752937
70SGK30.71607397
71RPS6KB20.69962133
72GRK10.68396029
73PAK30.67576238
74IKBKB0.67528560
75MAPK70.65169596
76YES10.65115398
77IRAK30.62171949
78PTK20.62129169
79ICK0.61591417
80LIMK10.57877053
81FGFR10.57651810
82PRKCI0.57126279
83BLK0.56696916
84MAP2K40.56505625
85OBSCN0.56192474
86FGR0.55471738
87STK240.55068835
88BCR0.54602811
89IRAK40.53605150
90CAMK1D0.51520531
91SGK20.50921936
92PDK20.50694289
93LATS10.50652815
94SMG10.50464533
95NEK10.49902713
96PHKG10.49446732
97PHKG20.49446732
98STK380.46229731
99STK30.46201714
100ALK0.45353167
101PRPF4B0.44170823
102MAPK150.43901385
103JAK10.43360997
104CDC42BPA0.42494791
105LRRK20.40968319
106PRKAA10.40286848
107MAPKAPK20.39972742
108RET0.38636606
109TYK20.38185857
110SGK10.38179468
111ROCK10.37669157
112PBK0.36873068
113HIPK20.36514596
114FGFR30.36334405
115JAK20.35991771
116MAP3K130.34029686
117RPS6KB10.33985224
118INSRR0.33284239
119FYN0.32655277
120STK38L0.32439912
121NLK0.32100110
122MAP4K10.30284022
123CDK120.30103959
124SRC0.29254149
125PRKCD0.28646496
126MAP3K60.28382953
127TBK10.27765744
128RPS6KA10.27189613
129ADRBK10.26856927
130GSK3A0.26653140
131SIK30.26377407
132PDGFRB0.25962274
133MAP2K70.25622982
134PINK10.24810757
135PDPK10.24600983
136DYRK1B0.23782429
137TAOK30.23257163
138PRKD10.22385383
139MTOR0.21437831

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006014.45722570
2Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005334.16764735
3Sulfur metabolism_Homo sapiens_hsa009203.99318711
4Mineral absorption_Homo sapiens_hsa049783.81630623
5Histidine metabolism_Homo sapiens_hsa003402.80674633
6Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049602.46922172
7Salivary secretion_Homo sapiens_hsa049702.30533162
8Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005122.18476212
9Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.03980747
10Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.97510268
11Phenylalanine metabolism_Homo sapiens_hsa003601.96583964
12Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.94247200
13Staphylococcus aureus infection_Homo sapiens_hsa051501.55945155
14Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.44005022
15Circadian rhythm_Homo sapiens_hsa047101.40279564
16Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.37255986
17Salmonella infection_Homo sapiens_hsa051321.36576597
18Cyanoamino acid metabolism_Homo sapiens_hsa004601.31603016
19Pancreatic secretion_Homo sapiens_hsa049721.30274321
20Tight junction_Homo sapiens_hsa045301.27432230
21Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.26587342
22Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.22082447
23Glycerophospholipid metabolism_Homo sapiens_hsa005641.21864884
24beta-Alanine metabolism_Homo sapiens_hsa004101.21211075
25Pertussis_Homo sapiens_hsa051331.20959776
26Fat digestion and absorption_Homo sapiens_hsa049751.15882563
27alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.15663891
28Choline metabolism in cancer_Homo sapiens_hsa052311.15622096
29Retinol metabolism_Homo sapiens_hsa008301.11824339
30Adherens junction_Homo sapiens_hsa045201.11317506
31Arachidonic acid metabolism_Homo sapiens_hsa005901.10008753
32Pentose and glucuronate interconversions_Homo sapiens_hsa000401.08328034
33Long-term depression_Homo sapiens_hsa047301.08241874
34Intestinal immune network for IgA production_Homo sapiens_hsa046721.05431825
35Vascular smooth muscle contraction_Homo sapiens_hsa042701.05379154
36Leukocyte transendothelial migration_Homo sapiens_hsa046701.04909460
37Serotonergic synapse_Homo sapiens_hsa047261.03288973
38NOD-like receptor signaling pathway_Homo sapiens_hsa046211.01789571
39Sphingolipid signaling pathway_Homo sapiens_hsa040711.01765039
40Linoleic acid metabolism_Homo sapiens_hsa005910.95487050
41Bile secretion_Homo sapiens_hsa049760.95040116
42Ras signaling pathway_Homo sapiens_hsa040140.94496627
43Chemical carcinogenesis_Homo sapiens_hsa052040.93700309
44Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.91522975
45Notch signaling pathway_Homo sapiens_hsa043300.90463705
46Leishmaniasis_Homo sapiens_hsa051400.90354869
47Endocytosis_Homo sapiens_hsa041440.88424944
48Glycerolipid metabolism_Homo sapiens_hsa005610.87017912
49Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.84267147
50Fructose and mannose metabolism_Homo sapiens_hsa000510.82878950
51African trypanosomiasis_Homo sapiens_hsa051430.81525325
52Bladder cancer_Homo sapiens_hsa052190.81223884
53GnRH signaling pathway_Homo sapiens_hsa049120.80833017
54Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.78743016
55Tuberculosis_Homo sapiens_hsa051520.78477707
56Gastric acid secretion_Homo sapiens_hsa049710.77112087
57Phospholipase D signaling pathway_Homo sapiens_hsa040720.76648939
58Toll-like receptor signaling pathway_Homo sapiens_hsa046200.75991957
59Hepatitis C_Homo sapiens_hsa051600.75720406
60TNF signaling pathway_Homo sapiens_hsa046680.75209217
61Influenza A_Homo sapiens_hsa051640.74693269
62Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.72503151
63Neurotrophin signaling pathway_Homo sapiens_hsa047220.70939534
64Phototransduction_Homo sapiens_hsa047440.70724112
65Insulin signaling pathway_Homo sapiens_hsa049100.69669175
66Toxoplasmosis_Homo sapiens_hsa051450.69552447
67Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.69400215
68Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.68086155
69Amoebiasis_Homo sapiens_hsa051460.67905758
70Thyroid cancer_Homo sapiens_hsa052160.67296761
71Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.66065922
72PPAR signaling pathway_Homo sapiens_hsa033200.64545206
73Starch and sucrose metabolism_Homo sapiens_hsa005000.63220940
74VEGF signaling pathway_Homo sapiens_hsa043700.62914631
75Tyrosine metabolism_Homo sapiens_hsa003500.62633069
76Phosphatidylinositol signaling system_Homo sapiens_hsa040700.59944636
77Glutathione metabolism_Homo sapiens_hsa004800.59252944
78Renin secretion_Homo sapiens_hsa049240.58326231
79Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.58282871
80NF-kappa B signaling pathway_Homo sapiens_hsa040640.58056365
81Sphingolipid metabolism_Homo sapiens_hsa006000.57902894
82RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.56908902
83Pancreatic cancer_Homo sapiens_hsa052120.56713595
84Steroid hormone biosynthesis_Homo sapiens_hsa001400.54699876
85Long-term potentiation_Homo sapiens_hsa047200.54452844
86Legionellosis_Homo sapiens_hsa051340.53767485
87Graft-versus-host disease_Homo sapiens_hsa053320.52949942
88Tryptophan metabolism_Homo sapiens_hsa003800.52447713
89Arginine biosynthesis_Homo sapiens_hsa002200.52027617
90Dorso-ventral axis formation_Homo sapiens_hsa043200.51902653
91Osteoclast differentiation_Homo sapiens_hsa043800.51172982
92Vibrio cholerae infection_Homo sapiens_hsa051100.50816383
93Chemokine signaling pathway_Homo sapiens_hsa040620.50161280
94Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.50154384
95Renal cell carcinoma_Homo sapiens_hsa052110.49041133
96Shigellosis_Homo sapiens_hsa051310.48470778
97Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.47507620
98ECM-receptor interaction_Homo sapiens_hsa045120.47497060
99Focal adhesion_Homo sapiens_hsa045100.46953162
100MAPK signaling pathway_Homo sapiens_hsa040100.45676358
101AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.44956713
102Malaria_Homo sapiens_hsa051440.44706169
103Regulation of actin cytoskeleton_Homo sapiens_hsa048100.44479547
104Glioma_Homo sapiens_hsa052140.44476291
105Jak-STAT signaling pathway_Homo sapiens_hsa046300.43737241
106Platelet activation_Homo sapiens_hsa046110.41736498
107Inositol phosphate metabolism_Homo sapiens_hsa005620.41629406
108Rap1 signaling pathway_Homo sapiens_hsa040150.41624173
109Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.41208071
110Ether lipid metabolism_Homo sapiens_hsa005650.41052251
111Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.40943755
112Protein digestion and absorption_Homo sapiens_hsa049740.40691876
113B cell receptor signaling pathway_Homo sapiens_hsa046620.40215968
114T cell receptor signaling pathway_Homo sapiens_hsa046600.39701624
115Glycosaminoglycan degradation_Homo sapiens_hsa005310.39280737
116ErbB signaling pathway_Homo sapiens_hsa040120.39076522
117Estrogen signaling pathway_Homo sapiens_hsa049150.39013792
118Axon guidance_Homo sapiens_hsa043600.38600626
119Drug metabolism - other enzymes_Homo sapiens_hsa009830.38310054
120Oxytocin signaling pathway_Homo sapiens_hsa049210.38127856
121Proteoglycans in cancer_Homo sapiens_hsa052050.37490467
122Chronic myeloid leukemia_Homo sapiens_hsa052200.37259725
123Endometrial cancer_Homo sapiens_hsa052130.36143679
124cGMP-PKG signaling pathway_Homo sapiens_hsa040220.35207286
125Arginine and proline metabolism_Homo sapiens_hsa003300.35174792
126Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.34759773
127Olfactory transduction_Homo sapiens_hsa047400.34249323
128Dilated cardiomyopathy_Homo sapiens_hsa054140.34184704
129Acute myeloid leukemia_Homo sapiens_hsa052210.33358538
130Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.33225700
131Galactose metabolism_Homo sapiens_hsa000520.33011496
132ABC transporters_Homo sapiens_hsa020100.32587943
1332-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.32114824
134Ovarian steroidogenesis_Homo sapiens_hsa049130.32001465
135Insulin resistance_Homo sapiens_hsa049310.31483405
136Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.31069441
137Calcium signaling pathway_Homo sapiens_hsa040200.30780270

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