TGM1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a membrane protein that catalyzes the addition of an alkyl group from an akylamine to a glutamine residue of a protein, forming an alkylglutamine in the protein. This protein alkylation leads to crosslinking of proteins and catenation of polyamines to proteins. This gene contains either one or two copies of a 22 nt repeat unit in its 3' UTR. Mutations in this gene have been associated with autosomal recessive lamellar ichthyosis (LI) and nonbullous congenital ichthyosiform erythroderma (NCIE). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1epidermis development (GO:0008544)8.35918056
2keratinocyte proliferation (GO:0043616)7.83086017
3detection of bacterium (GO:0016045)6.85985709
4* keratinization (GO:0031424)6.82998792
5molting cycle (GO:0042303)6.50917551
6hair cycle (GO:0042633)6.50917551
7long-chain fatty acid biosynthetic process (GO:0042759)6.39799363
8detection of other organism (GO:0098543)6.25457987
9establishment of skin barrier (GO:0061436)5.99701267
10gap junction assembly (GO:0016264)5.87172874
11lipoxygenase pathway (GO:0019372)5.81446866
12desmosome organization (GO:0002934)5.64506805
13regulation of water loss via skin (GO:0033561)5.58105160
14establishment of tissue polarity (GO:0007164)5.21827847
15establishment of planar polarity (GO:0001736)5.21827847
16regulation of natural killer cell differentiation (GO:0032823)5.18909389
17intermediate filament cytoskeleton organization (GO:0045104)4.99647204
18phosphatidylserine acyl-chain remodeling (GO:0036150)4.94123061
19negative regulation of interferon-gamma production (GO:0032689)4.84662966
20intermediate filament-based process (GO:0045103)4.83314273
21L-phenylalanine metabolic process (GO:0006558)4.81046033
22erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.81046033
23keratinocyte development (GO:0003334)4.69793880
24positive regulation of monocyte chemotaxis (GO:0090026)4.65819774
25cysteine metabolic process (GO:0006534)4.63553956
26phosphatidylinositol acyl-chain remodeling (GO:0036149)4.62737960
27erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.54894282
28L-phenylalanine catabolic process (GO:0006559)4.54894282
29sequestering of metal ion (GO:0051238)4.38146302
30positive regulation of epidermis development (GO:0045684)4.35600358
31sulfur amino acid catabolic process (GO:0000098)4.31452620
32hemidesmosome assembly (GO:0031581)4.30474008
33planar cell polarity pathway involved in neural tube closure (GO:0090179)4.28551103
34surfactant homeostasis (GO:0043129)4.22995693
35positive regulation of epidermal cell differentiation (GO:0045606)4.22730142
36negative regulation of keratinocyte proliferation (GO:0010839)4.17183156
37eyelid development in camera-type eye (GO:0061029)4.12188860
38glyoxylate metabolic process (GO:0046487)4.10549751
39regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)4.07220913
40aromatic amino acid family catabolic process (GO:0009074)4.07098280
41serine family amino acid catabolic process (GO:0009071)4.06909495
42phosphatidylethanolamine acyl-chain remodeling (GO:0036152)4.04446775
43glycine metabolic process (GO:0006544)4.03917999
44epithelium development (GO:0060429)3.90861067
45kynurenine metabolic process (GO:0070189)3.90818068
46phosphatidylglycerol acyl-chain remodeling (GO:0036148)3.88426296
47lysine metabolic process (GO:0006553)3.88280306
48lysine catabolic process (GO:0006554)3.88280306
49bundle of His cell to Purkinje myocyte communication (GO:0086069)3.85219394
50serine family amino acid metabolic process (GO:0009069)3.79729946
51urea cycle (GO:0000050)3.77949310
52urea metabolic process (GO:0019627)3.77949310
53transepithelial transport (GO:0070633)3.77895995
54triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.72689254
55tryptophan catabolic process (GO:0006569)3.71855573
56indole-containing compound catabolic process (GO:0042436)3.71855573
57indolalkylamine catabolic process (GO:0046218)3.71855573
58negative regulation of fibrinolysis (GO:0051918)3.69200118
59regulation of cholesterol homeostasis (GO:2000188)3.69155802
60multicellular organismal water homeostasis (GO:0050891)3.68368511
61high-density lipoprotein particle remodeling (GO:0034375)3.63152388
62detection of external biotic stimulus (GO:0098581)3.57207614
63regulation of gene silencing by miRNA (GO:0060964)3.55895665
64regulation of gene silencing by RNA (GO:0060966)3.55895665
65regulation of posttranscriptional gene silencing (GO:0060147)3.55895665
66phosphatidylcholine acyl-chain remodeling (GO:0036151)3.54302575
67ventricular cardiac muscle cell action potential (GO:0086005)3.48840655
68homocysteine metabolic process (GO:0050667)3.48796216
69serine family amino acid biosynthetic process (GO:0009070)3.47734731
70tryptophan metabolic process (GO:0006568)3.47098217
71negative regulation of interleukin-17 production (GO:0032700)3.46890368
72peptidyl-glutamic acid carboxylation (GO:0017187)3.46882305
73protein carboxylation (GO:0018214)3.46882305
74chemical homeostasis within a tissue (GO:0048875)3.46675740
75urate metabolic process (GO:0046415)3.45988064
76linoleic acid metabolic process (GO:0043651)3.44785366
77phospholipid efflux (GO:0033700)3.43485154
78nitrogen cycle metabolic process (GO:0071941)3.43016408
79hair follicle morphogenesis (GO:0031069)3.42627480
80regulation of monocyte chemotaxis (GO:0090025)3.41499918
81regulation of protein activation cascade (GO:2000257)3.41492425
82fibrinolysis (GO:0042730)3.41343299
83amino-acid betaine metabolic process (GO:0006577)3.40025912
84* keratinocyte differentiation (GO:0030216)3.36155545
85regulation of T cell chemotaxis (GO:0010819)3.35742836
86positive regulation of T cell chemotaxis (GO:0010820)3.35742836
87positive regulation of keratinocyte differentiation (GO:0045618)3.35119607
88alpha-linolenic acid metabolic process (GO:0036109)3.34775860
89water homeostasis (GO:0030104)3.34001462
90regulation of keratinocyte differentiation (GO:0045616)3.33832307
91atrioventricular valve morphogenesis (GO:0003181)3.33506606
92imidazole-containing compound metabolic process (GO:0052803)3.29790688
93polarized epithelial cell differentiation (GO:0030859)3.28753929
94regulation of epidermis development (GO:0045682)3.28376988
95cellular modified amino acid catabolic process (GO:0042219)3.27914077
96regulation of fibrinolysis (GO:0051917)3.26922790
97negative regulation of fatty acid biosynthetic process (GO:0045717)3.25333820
98phosphatidylserine metabolic process (GO:0006658)3.24852688
99embryonic process involved in female pregnancy (GO:0060136)3.21758282
100bile acid biosynthetic process (GO:0006699)3.20493633
101regulation of complement activation (GO:0030449)3.19164483
102proline metabolic process (GO:0006560)3.18281311
103regulation of keratinocyte proliferation (GO:0010837)3.18123163
104complement activation, alternative pathway (GO:0006957)3.16356180
105skin morphogenesis (GO:0043589)3.16141208
106reverse cholesterol transport (GO:0043691)3.13586097
107* epithelial cell differentiation (GO:0030855)3.12014283
108epithelial cell differentiation involved in prostate gland development (GO:0060742)3.11879686
109folic acid-containing compound biosynthetic process (GO:0009396)3.11685371
110proline biosynthetic process (GO:0006561)3.09199308
111alpha-amino acid catabolic process (GO:1901606)3.08880934
112response to UV-B (GO:0010224)3.08337084
113plasma lipoprotein particle clearance (GO:0034381)3.05592154
114response to phenylpropanoid (GO:0080184)3.03573352
115establishment of apical/basal cell polarity (GO:0035089)3.03511081
116aromatic amino acid family metabolic process (GO:0009072)3.03503737
117cell-substrate junction assembly (GO:0007044)3.03430989
118ceramide biosynthetic process (GO:0046513)3.02695696
119regulation of hippo signaling (GO:0035330)3.02635647
120regulation of ruffle assembly (GO:1900027)3.02399345
121L-ascorbic acid metabolic process (GO:0019852)3.01958866
122negative regulation of cholesterol transport (GO:0032375)3.01880405
123negative regulation of sterol transport (GO:0032372)3.01880405
124glutamate metabolic process (GO:0006536)3.01789980
125detection of biotic stimulus (GO:0009595)3.00447142
126primary alcohol catabolic process (GO:0034310)3.00022054
127epithelial cell-cell adhesion (GO:0090136)2.99446613
128triglyceride homeostasis (GO:0070328)2.96865951
129acylglycerol homeostasis (GO:0055090)2.96865951
130regulation of triglyceride catabolic process (GO:0010896)2.96465592
131ethanol oxidation (GO:0006069)2.94545646
132fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.93371890
133ectoderm development (GO:0007398)2.93000758
134cellular amino acid catabolic process (GO:0009063)2.91779315
135acetyl-CoA metabolic process (GO:0006084)2.91513401
136regulation of heart rate by cardiac conduction (GO:0086091)2.91377646
137* peptide cross-linking (GO:0018149)2.87787156
138regulation of epidermal cell differentiation (GO:0045604)2.86511650
139interferon-gamma secretion (GO:0072643)2.85861240
140bile acid metabolic process (GO:0008206)2.85850099
141protein-lipid complex remodeling (GO:0034368)2.85515921
142macromolecular complex remodeling (GO:0034367)2.85515921
143plasma lipoprotein particle remodeling (GO:0034369)2.85515921
144drug catabolic process (GO:0042737)2.85478820
145drug transmembrane transport (GO:0006855)2.83025094
146maternal placenta development (GO:0001893)2.77174045
147glutamine family amino acid biosynthetic process (GO:0009084)2.76709941
148intermediate filament organization (GO:0045109)2.76364139
149folic acid metabolic process (GO:0046655)2.75116605
150low-density lipoprotein particle clearance (GO:0034383)2.75001029
151tetrahydrofolate metabolic process (GO:0046653)2.74838631
152regulation of cholesterol esterification (GO:0010872)2.74630535
153aspartate family amino acid catabolic process (GO:0009068)2.74608506
154hormone catabolic process (GO:0042447)2.73293198
155cholesterol homeostasis (GO:0042632)2.72064420
156sterol homeostasis (GO:0055092)2.71253877
157alditol phosphate metabolic process (GO:0052646)2.67145759
158cell communication involved in cardiac conduction (GO:0086065)2.65922848
159lateral sprouting from an epithelium (GO:0060601)2.63451173
160hypotonic response (GO:0006971)2.60267773
161regulation of natural killer cell activation (GO:0032814)2.57962534
162Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.55832207
163regulation of neuron projection regeneration (GO:0070570)2.55214537
164regulation of axon regeneration (GO:0048679)2.55214537
165intestinal epithelial cell development (GO:0060576)2.54165192
166protein localization to endosome (GO:0036010)2.53266667
167regulation of establishment of planar polarity (GO:0090175)2.50358130
168defense response to fungus (GO:0050832)2.49944908
169skin development (GO:0043588)2.47718722
170positive regulation of granulocyte chemotaxis (GO:0071624)2.46810435
171positive regulation of Cdc42 GTPase activity (GO:0043089)2.43450748
172cellular component disassembly involved in execution phase of apoptosis (GO:0006921)2.42683299
173wound healing (GO:0042060)2.38591041
174apical protein localization (GO:0045176)2.38041364
175negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.37965024
176hair cell differentiation (GO:0035315)2.37450730
177endosome organization (GO:0007032)2.33038547
178phospholipid catabolic process (GO:0009395)2.32854164
179regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.32778819
180hair cycle process (GO:0022405)2.31775283
181molting cycle process (GO:0022404)2.31775283
182cardiac conduction (GO:0061337)2.28123843
183* epidermal cell differentiation (GO:0009913)10.4270306

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human7.54339905
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse5.22679264
3RXR_22158963_ChIP-Seq_LIVER_Mouse3.79452277
4PPARA_22158963_ChIP-Seq_LIVER_Mouse3.56353789
5E2F7_22180533_ChIP-Seq_HELA_Human2.95700515
6PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.77110474
7LXR_22158963_ChIP-Seq_LIVER_Mouse2.74224580
8TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.71341856
9KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.52480261
10KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.52480261
11KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.52480261
12EGR1_23403033_ChIP-Seq_LIVER_Mouse2.51785245
13POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.44191047
14STAT6_21828071_ChIP-Seq_BEAS2B_Human2.32944479
15SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.31829790
16STAT3_1855785_ChIP-Seq_MESCs_Mouse2.18740448
17* CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.15674755
18FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.15651255
19ESR1_15608294_ChIP-ChIP_MCF-7_Human2.12127040
20TFAP2C_20629094_ChIP-Seq_MCF-7_Human2.01339599
21NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.97989340
22TCF3_18692474_ChIP-Seq_MEFs_Mouse1.93887836
23ZNF263_19887448_ChIP-Seq_K562_Human1.91837950
24NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.83651527
25TP63_22573176_ChIP-Seq_HFKS_Human1.80709868
26ESR1_21235772_ChIP-Seq_MCF-7_Human1.79937183
27CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.79925257
28NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.76507460
29MYC_18555785_ChIP-Seq_MESCs_Mouse1.74873716
30CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.66609065
31PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.65581712
32NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.63859026
33NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.62758652
34UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.62291298
35KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.61108651
36EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.61064142
37RUNX1_27514584_Chip-Seq_MCF-7_Human1.56499727
38* P63_26484246_Chip-Seq_KERATINOCYTES_Human1.55701949
39SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.55045350
40TCF3_18692474_ChIP-Seq_MESCs_Mouse1.52881557
41NANOG_18555785_ChIP-Seq_MESCs_Mouse1.52214972
42TP63_23658742_ChIP-Seq_EP156T_Human1.51931630
43MYC_19079543_ChIP-ChIP_MESCs_Mouse1.51093582
44SOX2_20726797_ChIP-Seq_SW620_Human1.50084289
45ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.45117863
46KLF5_25053715_ChIP-Seq_YYC3_Human1.44983253
47SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.44456221
48ESR2_21235772_ChIP-Seq_MCF-7_Human1.42927080
49TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.41807809
50RACK7_27058665_Chip-Seq_MCF-7_Human1.41411420
51ATF3_27146783_Chip-Seq_COLON_Human1.41210191
52HIF1A_21447827_ChIP-Seq_MCF-7_Human1.36137471
53GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.35539363
54SMC4_20622854_ChIP-Seq_HELA_Human1.34849097
55STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.33801599
56CLOCK_20551151_ChIP-Seq_293T_Human1.33142280
57RARG_19884340_ChIP-ChIP_MEFs_Mouse1.32736087
58FOXM1_23109430_ChIP-Seq_U2OS_Human1.31369396
59KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.29624033
60UBF1/2_26484160_Chip-Seq_HMECs_Human1.29109577
61EGR1_19374776_ChIP-ChIP_THP-1_Human1.28479375
62SOX2_18692474_ChIP-Seq_MEFs_Mouse1.28205662
63CTCF_27219007_Chip-Seq_Bcells_Human1.27232804
64ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.26972144
65TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.26391621
66AR_21909140_ChIP-Seq_LNCAP_Human1.25502792
67ZNF217_24962896_ChIP-Seq_MCF-7_Human1.20964051
68FOXO3_23340844_ChIP-Seq_DLD1_Human1.20824184
69* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.20507127
70ESR1_20079471_ChIP-ChIP_T-47D_Human1.19409027
71* NANOG_18692474_ChIP-Seq_MEFs_Mouse1.18699789
72GATA3_24758297_ChIP-Seq_MCF-7_Human1.18170212
73KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.18140446
74OCT4_18692474_ChIP-Seq_MEFs_Mouse1.17685921
75GATA6_25053715_ChIP-Seq_YYC3_Human1.16319705
76LXR_22292898_ChIP-Seq_THP-1_Human1.15895001
77DNAJC2_21179169_ChIP-ChIP_NT2_Human1.13863253
78POU5F1_16518401_ChIP-PET_MESCs_Mouse1.13757906
79SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.12740161
80P300_27058665_Chip-Seq_ZR-75-30cells_Human1.12639689
81SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.11128712
82GATA6_21074721_ChIP-Seq_CACO-2_Human1.08647768
83TCF4_18268006_ChIP-ChIP_LS174T_Human1.07855688
84HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.07312267
85ERG_21242973_ChIP-ChIP_JURKAT_Human1.07195311
86CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.06814864
87ELK3_25401928_ChIP-Seq_HUVEC_Human1.06167861
88PPAR_26484153_Chip-Seq_NCI-H1993_Human1.05642743
89* SA1_27219007_Chip-Seq_ERYTHROID_Human1.04954397
90KLF4_18555785_ChIP-Seq_MESCs_Mouse1.03411498
91MYC_22102868_ChIP-Seq_BL_Human1.03259668
92E2F1_20622854_ChIP-Seq_HELA_Human1.02962983
93SOX2_18692474_ChIP-Seq_MESCs_Mouse1.02948502
94EGR1_19032775_ChIP-ChIP_M12_Human1.02868696
95CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.02512904
96* NANOG_18692474_ChIP-Seq_MESCs_Mouse1.01947949
97RXR_22108803_ChIP-Seq_LS180_Human1.01436619
98POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.00829172
99MYC_19030024_ChIP-ChIP_MESCs_Mouse1.00077991
100FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.99912252
101BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.99852343
102NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.99758652
103SOX2_27498859_Chip-Seq_STOMACH_Mouse0.99199514
104SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.98498220
105SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.98498220
106ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.98363001
107NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.97991258
108ERG_20517297_ChIP-Seq_VCAP_Human0.97415598
109JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.96911280
110GATA4_25053715_ChIP-Seq_YYC3_Human0.96800808
111NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.96234348
112SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.95734210
113MYC_18358816_ChIP-ChIP_MESCs_Mouse0.95472890
114KDM2B_26808549_Chip-Seq_SUP-B15_Human0.94537907
115SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.94274015
116EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.93945889
117RXRA_24833708_ChIP-Seq_LIVER_Mouse0.93011805
118KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.92476660
119ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.91877719
120NELFA_20434984_ChIP-Seq_ESCs_Mouse0.91835087
121JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.90969170
122TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.90188447
123CTCF_20526341_ChIP-Seq_ESCs_Human0.89326815
124P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.89188838
125KAP1_27257070_Chip-Seq_ESCs_Mouse0.88964946
126TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.88943269
127POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.88896704
128KDM2B_26808549_Chip-Seq_DND41_Human0.87081335
129SOX9_24532713_ChIP-Seq_HFSC_Mouse0.86241105
130ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.86071208
131TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.85960605
132* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.85950779
133BCOR_27268052_Chip-Seq_Bcells_Human0.84887608
134KDM2B_26808549_Chip-Seq_K562_Human0.83915864
135CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.83915224
136ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.83717604
137CJUN_26792858_Chip-Seq_BT549_Human0.83478560
138SOX2_18555785_ChIP-Seq_MESCs_Mouse0.82372821
139E2F1_18555785_ChIP-Seq_MESCs_Mouse0.82263844
140TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.81874786
141P68_20966046_ChIP-Seq_HELA_Human0.81626032
142FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.81332944
143RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.80239290
144POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.79697628
145HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.79063715
146CREB1_26743006_Chip-Seq_LNCaP_Human0.79002057
147THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.78427288
148* TCF7_22412390_ChIP-Seq_EML_Mouse0.75992011
149CDX2_20551321_ChIP-Seq_CACO-2_Human0.75506305
150VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.74982141
151* SA1_27219007_Chip-Seq_Bcells_Human0.73085249
152SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.71657025
153AHR_22903824_ChIP-Seq_MCF-7_Human0.71351931
154TBX20_22080862_ChIP-Seq_HEART_Mouse0.69283353
155TBX20_22328084_ChIP-Seq_HEART_Mouse0.69283353
156TRIM28_21343339_ChIP-Seq_HEK293_Human0.68579324
157FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.68071181
158BCL6_27268052_Chip-Seq_Bcells_Human0.67365435
159YY1_22570637_ChIP-Seq_MALME-3M_Human0.64782608

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1* MP0002796_impaired_skin_barrier5.00826415
2MP0005360_urolithiasis4.03839769
3MP0010234_abnormal_vibrissa_follicle3.99869463
4MP0002139_abnormal_hepatobiliary_system3.85444613
5MP0003705_abnormal_hypodermis_morpholog3.50158760
6MP0005085_abnormal_gallbladder_physiolo3.28383244
7* MP0005501_abnormal_skin_physiology3.28149044
8MP0005275_abnormal_skin_tensile3.20082281
9MP0000579_abnormal_nail_morphology3.12030354
10MP0003806_abnormal_nucleotide_metabolis3.08410650
11MP0005365_abnormal_bile_salt2.90133604
12MP0004885_abnormal_endolymph2.59773211
13MP0005377_hearing/vestibular/ear_phenot2.58874853
14MP0003878_abnormal_ear_physiology2.58874853
15MP0003191_abnormal_cellular_cholesterol2.57957774
16MP0003941_abnormal_skin_development2.56242146
17MP0004043_abnormal_pH_regulation2.56076983
18MP0002254_reproductive_system_inflammat2.47577675
19MP0004264_abnormal_extraembryonic_tissu2.38693279
20MP0003453_abnormal_keratinocyte_physiol2.35627078
21MP0004019_abnormal_vitamin_homeostasis2.24864252
22MP0008875_abnormal_xenobiotic_pharmacok2.23867714
23MP0002098_abnormal_vibrissa_morphology2.16190917
24* MP0001216_abnormal_epidermal_layer2.11871936
25MP0005409_darkened_coat_color2.06434059
26MP0002060_abnormal_skin_morphology1.97421282
27MP0003566_abnormal_cell_adhesion1.97088836
28MP0009840_abnormal_foam_cell1.94019119
29MP0010352_gastrointestinal_tract_polyps1.91286290
30MP0004947_skin_inflammation1.83151785
31MP0010678_abnormal_skin_adnexa1.81807647
32MP0000467_abnormal_esophagus_morphology1.80031612
33MP0000377_abnormal_hair_follicle1.78216144
34MP0010329_abnormal_lipoprotein_level1.72938545
35MP0000647_abnormal_sebaceous_gland1.66507083
36MP0003252_abnormal_bile_duct1.61462848
37MP0005332_abnormal_amino_acid1.58975282
38* MP0010771_integument_phenotype1.58005337
39MP0005083_abnormal_biliary_tract1.57994724
40MP0000383_abnormal_hair_follicle1.57342662
41MP0005451_abnormal_body_composition1.54430274
42MP0009053_abnormal_anal_canal1.49793199
43MP0005023_abnormal_wound_healing1.42842011
44MP0002095_abnormal_skin_pigmentation1.38537676
45MP0001851_eye_inflammation1.32435744
46MP0000427_abnormal_hair_cycle1.31952344
47MP0004185_abnormal_adipocyte_glucose1.30457861
48MP0002138_abnormal_hepatobiliary_system1.27100888
49MP0003011_delayed_dark_adaptation1.26609259
50* MP0009931_abnormal_skin_appearance1.26526240
51MP0000609_abnormal_liver_physiology1.25733654
52MP0000762_abnormal_tongue_morphology1.20039803
53MP0001243_abnormal_dermal_layer1.16338624
54MP0005076_abnormal_cell_differentiation1.16107372
55MP0004381_abnormal_hair_follicle1.13657627
56MP0001849_ear_inflammation1.12837719
57MP0001666_abnormal_nutrient_absorption1.12637318
58MP0003186_abnormal_redox_activity1.11992100
59MP0002234_abnormal_pharynx_morphology1.07656570
60MP0000367_abnormal_coat/_hair1.05854025
61MP0001191_abnormal_skin_condition1.03373654
62MP0004957_abnormal_blastocyst_morpholog1.01841523
63MP0005319_abnormal_enzyme/_coenzyme1.01769580
64MP0001881_abnormal_mammary_gland0.99216513
65MP0002118_abnormal_lipid_homeostasis0.95746745
66MP0009643_abnormal_urine_homeostasis0.95322507
67MP0004197_abnormal_fetal_growth/weight/0.93527305
68MP0008057_abnormal_DNA_replication0.88198690
69MP0002086_abnormal_extraembryonic_tissu0.87080389
70MP0001188_hyperpigmentation0.85548300
71MP0003195_calcinosis0.83933781
72MP0005666_abnormal_adipose_tissue0.82322942
73MP0000627_abnormal_mammary_gland0.81666909
74MP0003950_abnormal_plasma_membrane0.78271799
75MP0003315_abnormal_perineum_morphology0.76985652
76MP0000598_abnormal_liver_morphology0.74938230
77MP0001730_embryonic_growth_arrest0.69856693
78MP0003718_maternal_effect0.68823875
79MP0005670_abnormal_white_adipose0.68274912
80MP0004272_abnormal_basement_membrane0.66747134
81MP0004782_abnormal_surfactant_physiolog0.66515830
82MP0000566_synostosis0.64814062
83MP0002136_abnormal_kidney_physiology0.64539790
84MP0002084_abnormal_developmental_patter0.63894730
85MP0002111_abnormal_tail_morphology0.63030727
86MP0005380_embryogenesis_phenotype0.61777432
87MP0001672_abnormal_embryogenesis/_devel0.61777432
88MP0009379_abnormal_foot_pigmentation0.60023846
89* MP0001784_abnormal_fluid_regulation0.59922718
90MP0004133_heterotaxia0.59382198
91MP0000678_abnormal_parathyroid_gland0.58857576
92MP0005248_abnormal_Harderian_gland0.56881878
93MP0001697_abnormal_embryo_size0.56188878
94MP0002088_abnormal_embryonic_growth/wei0.56141861
95MP0009780_abnormal_chondrocyte_physiolo0.56060377
96MP0005266_abnormal_metabolism0.55942376
97MP0003984_embryonic_growth_retardation0.55093891
98MP0003436_decreased_susceptibility_to0.54628468
99MP0000537_abnormal_urethra_morphology0.54586393
100MP0000470_abnormal_stomach_morphology0.53936634
101MP0010094_abnormal_chromosome_stability0.52828692
102MP0005584_abnormal_enzyme/coenzyme_acti0.52740806
103MP0009763_increased_sensitivity_to0.52732894
104MP0000465_gastrointestinal_hemorrhage0.51593658
105MP0010030_abnormal_orbit_morphology0.51355649
106MP0000350_abnormal_cell_proliferation0.51165669
107MP0005375_adipose_tissue_phenotype0.51151263
108MP0000371_diluted_coat_color0.51043625
109MP0003890_abnormal_embryonic-extraembry0.50866862
110MP0008260_abnormal_autophagy0.50672802
111MP0010307_abnormal_tumor_latency0.50669262
112MP0000477_abnormal_intestine_morphology0.50010504
113MP0003119_abnormal_digestive_system0.49956631
114MP0003693_abnormal_embryo_hatching0.49728932
115MP0001915_intracranial_hemorrhage0.49566869
116MP0002877_abnormal_melanocyte_morpholog0.49565103
117MP0005395_other_phenotype0.49210254
118MP0002019_abnormal_tumor_incidence0.48687926
119MP0003638_abnormal_response/metabolism_0.48019809
120MP0003111_abnormal_nucleus_morphology0.47531036
121MP0001340_abnormal_eyelid_morphology0.46518435
122MP0003755_abnormal_palate_morphology0.44570658
123MP0000858_altered_metastatic_potential0.41965278
124MP0001765_abnormal_ion_homeostasis0.39446206
125MP0003763_abnormal_thymus_physiology0.36831799
126MP0000003_abnormal_adipose_tissue0.36705462
127MP0005193_abnormal_anterior_eye0.34948659
128MP0002006_tumorigenesis0.34021494
129MP0001186_pigmentation_phenotype0.31677486
130MP0000685_abnormal_immune_system0.30342601
131MP0002075_abnormal_coat/hair_pigmentati0.28554012
132MP0001958_emphysema0.27616985
133MP0002282_abnormal_trachea_morphology0.26506493
134MP0008004_abnormal_stomach_pH0.25991967
135MP0009333_abnormal_splenocyte_physiolog0.25658050
136MP0008789_abnormal_olfactory_epithelium0.24810563
137MP0002177_abnormal_outer_ear0.24568025
138MP0002133_abnormal_respiratory_system0.24276181
139MP0005388_respiratory_system_phenotype0.24276181
140MP0003828_pulmonary_edema0.24031687
141MP0002009_preneoplasia0.22697864
142MP0002166_altered_tumor_susceptibility0.20701681
143MP0003300_gastrointestinal_ulcer0.19538858
144MP0008438_abnormal_cutaneous_collagen0.18876848
145MP0001485_abnormal_pinna_reflex0.18794407
146MP0005394_taste/olfaction_phenotype0.17044741
147MP0005499_abnormal_olfactory_system0.17044741
148MP0002249_abnormal_larynx_morphology0.16908311
149MP0003045_fibrosis0.15243757
150MP0003448_altered_tumor_morphology0.14383311

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of nail color (HP:0100643)5.63715524
2Abnormality of secondary sexual hair (HP:0009888)5.04760406
3Abnormality of the axillary hair (HP:0100134)5.04760406
4* Hypotrichosis (HP:0001006)5.01367197
5Parakeratosis (HP:0001036)4.86040812
6Abnormality of monocarboxylic acid metabolism (HP:0010996)4.81325473
7Intrahepatic cholestasis (HP:0001406)4.55511517
8Woolly hair (HP:0002224)4.46808061
9Oral leukoplakia (HP:0002745)4.39150576
10Plantar hyperkeratosis (HP:0007556)4.32861846
11Right ventricular cardiomyopathy (HP:0011663)4.31486495
12Deep venous thrombosis (HP:0002625)4.21267404
13Increased IgE level (HP:0003212)4.21142176
14Onycholysis (HP:0001806)4.18940326
15Pili torti (HP:0003777)4.14784320
16Palmoplantar hyperkeratosis (HP:0000972)4.11224563
17Alopecia of scalp (HP:0002293)3.97590604
18Abnormality of aromatic amino acid family metabolism (HP:0004338)3.96135220
19Xanthomatosis (HP:0000991)3.95475358
20Palmar hyperkeratosis (HP:0010765)3.95065248
21Absent eyelashes (HP:0000561)3.80732404
22Hypobetalipoproteinemia (HP:0003563)3.58244339
23Abnormality of placental membranes (HP:0011409)3.40472469
24Amniotic constriction ring (HP:0009775)3.40472469
25Abnormality of pyrimidine metabolism (HP:0004353)3.35266260
26Absent hair (HP:0002298)3.32035269
27Fragile nails (HP:0001808)3.25560812
28* Nail dystrophy (HP:0008404)3.24977488
29Sparse scalp hair (HP:0002209)3.19827526
30Abnormality of glutamine family amino acid metabolism (HP:0010902)3.16757425
31Milia (HP:0001056)3.08129761
32Hyperglycinuria (HP:0003108)3.05113265
33Follicular hyperkeratosis (HP:0007502)3.04376145
34Thick nail (HP:0001805)3.01058397
35Abnormal hair laboratory examination (HP:0003328)2.97667546
36Hyperammonemia (HP:0001987)2.95564411
37Abnormality of sulfur amino acid metabolism (HP:0004339)2.88367626
38Epidermoid cyst (HP:0200040)2.87946577
39Hypolipoproteinemia (HP:0010981)2.85142414
40Ridged nail (HP:0001807)2.83514879
41Abnormal blistering of the skin (HP:0008066)2.82299269
42Abnormality of nucleobase metabolism (HP:0010932)2.81248803
43* Congenital ichthyosiform erythroderma (HP:0007431)2.81058161
44Furrowed tongue (HP:0000221)2.80520675
45Gout (HP:0001997)2.79612651
46Blepharitis (HP:0000498)2.77564661
47Hyperlipoproteinemia (HP:0010980)2.76457493
48Complement deficiency (HP:0004431)2.74730054
49* Ectropion (HP:0000656)2.74279676
50Hyperglycinemia (HP:0002154)2.72227380
51Spastic diplegia (HP:0001264)2.70701079
52Abnormality of serine family amino acid metabolism (HP:0010894)2.68162957
53Abnormality of glycine metabolism (HP:0010895)2.68162957
54Erythema (HP:0010783)2.63911058
55Hypoalphalipoproteinemia (HP:0003233)2.61013183
56Natal tooth (HP:0000695)2.58470763
57Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.57963852
58Prolonged partial thromboplastin time (HP:0003645)2.57411564
59Sparse eyelashes (HP:0000653)2.56589092
60Malnutrition (HP:0004395)2.55276282
61Abnormality of aspartate family amino acid metabolism (HP:0010899)2.54499652
62Abnormality of purine metabolism (HP:0004352)2.54240075
63Multifactorial inheritance (HP:0001426)2.50909037
64Conjunctival hamartoma (HP:0100780)2.49941401
65Autoamputation (HP:0001218)2.49428448
66Laryngomalacia (HP:0001601)2.40490815
67Esophageal varix (HP:0002040)2.39517314
68Abnormality of the common coagulation pathway (HP:0010990)2.38868081
69Distal lower limb muscle weakness (HP:0009053)2.38056708
70Joint hemorrhage (HP:0005261)2.38025907
71Abnormality of complement system (HP:0005339)2.37525704
72Popliteal pterygium (HP:0009756)2.34698200
73Advanced eruption of teeth (HP:0006288)2.31912482
74Hypoplastic labia majora (HP:0000059)2.29031248
75Ketosis (HP:0001946)2.27525163
76* Erythroderma (HP:0001019)2.25148098
77Abnormality of methionine metabolism (HP:0010901)2.23632638
78Anonychia (HP:0001798)2.22204447
79Urticaria (HP:0001025)2.17108155
80Abnormality of the salivary glands (HP:0010286)2.16883211
81Curly hair (HP:0002212)2.14474261
82Fat malabsorption (HP:0002630)2.13628610
83Hyperhidrosis (HP:0000975)2.12034051
84Delayed CNS myelination (HP:0002188)2.11568550
85Neonatal onset (HP:0003623)2.11153181
86Vascular calcification (HP:0004934)2.10227303
87Abnormality of the labia majora (HP:0012881)2.08926143
88Recurrent corneal erosions (HP:0000495)2.08503356
89Hypochromic microcytic anemia (HP:0004840)2.08101207
90Abnormality of the Achilles tendon (HP:0005109)2.07888985
91Lip pit (HP:0100267)2.05645336
92Acanthosis nigricans (HP:0000956)2.05381076
93Ependymoma (HP:0002888)2.04854972
94Pseudobulbar signs (HP:0002200)1.97852940
95Increased purine levels (HP:0004368)1.96994339
96Hyperuricemia (HP:0002149)1.96994339
97Back pain (HP:0003418)1.94984976
98Pustule (HP:0200039)1.93592161
99Keratoconjunctivitis sicca (HP:0001097)1.92427437
100Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.91540989
101Rickets (HP:0002748)1.89973100
102Menorrhagia (HP:0000132)1.88714600
103* Gangrene (HP:0100758)1.88520007
104Axonal loss (HP:0003447)1.88170047
105Carious teeth (HP:0000670)1.87881049
106Hyporeflexia of lower limbs (HP:0002600)1.84533858
107Skin ulcer (HP:0200042)1.83937805
108* Corneal erosion (HP:0200020)1.83916212
109Myocardial infarction (HP:0001658)1.82353955
110Cardiovascular calcification (HP:0011915)1.81701970
111Abnormality of the intrinsic pathway (HP:0010989)1.79826976
112* Dehydration (HP:0001944)1.79772847
113Corneal dystrophy (HP:0001131)1.79601233
114Selective tooth agenesis (HP:0001592)1.79424302
115Hypercholesterolemia (HP:0003124)1.78581312
116Hypergammaglobulinemia (HP:0010702)1.78230142
117* Palmoplantar keratoderma (HP:0000982)1.78051977
118Hypoglycemic coma (HP:0001325)1.77800566
119Hamartoma of the eye (HP:0010568)1.77143408
120Abnormality of hair growth rate (HP:0011363)1.77101972
121Slow-growing hair (HP:0002217)1.77101972
122* Hypohidrosis (HP:0000966)1.74188303
123* Pruritus (HP:0000989)1.74106058
124Brittle hair (HP:0002299)1.73331027
125Abnormal hemoglobin (HP:0011902)1.73137144
126Dry hair (HP:0011359)1.73082952
127Increased mean platelet volume (HP:0011877)1.72944297
128Keratoconjunctivitis (HP:0001096)1.72855187
129Abnormality of transition element cation homeostasis (HP:0011030)1.72234856
130Paralysis (HP:0003470)1.72198960
131Hypoplastic toenails (HP:0001800)1.71633442
132Glomerulosclerosis (HP:0000096)1.71430788
133Abnormality of the fingernails (HP:0001231)1.70983327
134Abnormal cartilage morphology (HP:0002763)1.70147086
135Fatigable weakness (HP:0003473)1.70029884
136Abnormality of the neuromuscular junction (HP:0003398)1.70029884
137Esophageal atresia (HP:0002032)1.68418437
138Hepatocellular carcinoma (HP:0001402)1.68328697
139Hydroxyprolinuria (HP:0003080)1.67546809
140Abnormality of proline metabolism (HP:0010907)1.67546809
141Ventricular tachycardia (HP:0004756)1.67529539
142Fine hair (HP:0002213)1.67073361
143Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.66783058
144Oligodontia (HP:0000677)1.66728032
145Steatorrhea (HP:0002570)1.66588607
146Melanocytic nevus (HP:0000995)1.66574440
147Squamous cell carcinoma (HP:0002860)1.66051682
148Papilloma (HP:0012740)1.59412282
149Verrucae (HP:0200043)1.59412282
150Xerostomia (HP:0000217)1.58030530
151Recurrent bacterial skin infections (HP:0005406)1.56447597
152* Lack of skin elasticity (HP:0100679)1.55893439
153Atrophic scars (HP:0001075)1.49973872
154Duplicated collecting system (HP:0000081)1.48966194
155Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.43134548
156Pterygium (HP:0001059)1.42737008
157Labial hypoplasia (HP:0000066)1.42331359
158Preauricular skin tag (HP:0000384)1.41697256
159Abnormality of small intestinal villus morphology (HP:0011472)1.40233093
160Villous atrophy (HP:0011473)1.40233093
161Skin pits (HP:0100276)1.38652307
162Ankyloglossia (HP:0010296)1.36147619

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA26.39704258
2ERN13.15887049
3RPS6KB23.06129338
4MAPKAPK33.01451476
5CDK122.95311434
6STK242.82156356
7BCKDK2.36943913
8PKN22.33698996
9STK102.07736609
10FGFR42.07348432
11TRIB32.02999013
12NEK12.00670460
13MAP3K31.95446818
14LATS11.92522851
15MST41.82762768
16MAP3K111.71490427
17FGFR31.57204289
18SGK4941.55170282
19SGK2231.55170282
20BLK1.54454126
21FER1.53864768
22MST1R1.52467002
23CDK61.49789162
24EPHA31.47411204
25SIK11.45928046
26EEF2K1.45786702
27MAP3K61.43280895
28PTK61.40812479
29RIPK11.36006431
30PBK1.35237602
31MET1.34125676
32LRRK21.33149830
33ICK1.32028159
34TTK1.29572855
35FLT31.26702470
36PTK21.26421271
37BMX1.24950854
38STK38L1.23987330
39PAK41.21360448
40CDK71.19666436
41LATS21.17376142
42MAP2K31.15838051
43IRAK31.15687041
44WEE11.14181002
45PRPF4B1.13914944
46GRK61.11561040
47ERBB41.10948855
48WNK11.10619147
49PIM11.06739231
50EPHB11.06533851
51MAP3K81.05564310
52MAP3K101.05051379
53SMG11.03057925
54MAPK111.01616594
55FGFR11.01551510
56ERBB30.98533145
57PIM20.96455990
58MAP3K10.96091923
59MTOR0.94055017
60CSK0.93753233
61IRAK10.93303631
62MATK0.93212207
63TYK20.92928253
64PRKCI0.92332264
65TGFBR20.92317233
66CDK40.91919765
67PRKD20.91737182
68MARK20.89191412
69PDGFRA0.85018228
70DYRK1B0.83378190
71NME10.83263286
72GSK3A0.81413546
73ALK0.81002816
74DDR20.80387198
75JAK30.80381722
76MAP3K130.76881419
77TTN0.76555143
78NEK20.72896590
79STK30.70096186
80MAP2K20.68181392
81BUB10.67565321
82IKBKB0.67144561
83TYRO30.67019827
84KSR20.65365807
85MAPK70.62425799
86CDC42BPA0.60041070
87DMPK0.59855928
88MAP2K60.59224666
89ARAF0.56604349
90RPS6KA40.56382112
91PIK3CG0.55818249
92PDGFRB0.55662213
93MAPK150.55447275
94TGFBR10.55372254
95PDK40.54945906
96PDK30.54945906
97MAP3K70.54444653
98TAOK10.53921260
99EPHB20.53710092
100AURKB0.53654990
101MAP3K120.50807367
102IRAK20.49238948
103AURKA0.48760173
104JAK20.46713920
105RPS6KA10.46216652
106AKT20.45818759
107RET0.45175639
108MAP3K20.44626925
109PLK10.44524050
110NTRK10.44180264
111MAPKAPK20.42951825
112CAMK1D0.41837052
113MAP3K90.40809455
114EGFR0.39845312
115CHEK20.38599924
116STK380.38205109
117SCYL20.38034111
118PDK20.36623456
119CDC70.36413432
120FGR0.36189727
121MAP2K10.35724385
122ACVR1B0.35354101
123CHEK10.35163631
124STK40.34632615
125ERBB20.34330484
126ABL20.33655169
127CSNK1E0.33402553
128SGK10.33311467
129DYRK30.31727114
130TRPM70.31593454
131SGK30.30657008
132CSNK1D0.30332154
133TBK10.29866638
134BRSK20.29166026
135IRAK40.29002861
136PRKAA20.27453804
137HCK0.26822750
138IKBKE0.26559652
139PAK20.26049212
140MYLK0.25980859
141TESK10.25192335
142ZAP700.24936641
143RPS6KA20.23458761
144RPS6KB10.23099809
145HIPK20.22536011
146ILK0.22034875
147SIK30.21540289
148LMTK20.20373207

Predicted pathways (KEGG)

RankGene SetZ-score
1Butirosin and neomycin biosynthesis_Homo sapiens_hsa005244.32674521
2Nitrogen metabolism_Homo sapiens_hsa009103.15233980
3Ether lipid metabolism_Homo sapiens_hsa005653.11350484
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.03996000
5Primary bile acid biosynthesis_Homo sapiens_hsa001203.01420243
6Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.96080122
7Arginine biosynthesis_Homo sapiens_hsa002202.82691856
8Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.43880724
9VEGF signaling pathway_Homo sapiens_hsa043702.40568034
10GnRH signaling pathway_Homo sapiens_hsa049122.34829211
11Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.34559791
12Complement and coagulation cascades_Homo sapiens_hsa046102.21490772
132-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.16598149
14Tryptophan metabolism_Homo sapiens_hsa003802.11521868
15Cyanoamino acid metabolism_Homo sapiens_hsa004602.11419022
16Pentose and glucuronate interconversions_Homo sapiens_hsa000402.07125843
17Amoebiasis_Homo sapiens_hsa051462.05165419
18Caffeine metabolism_Homo sapiens_hsa002322.04571303
19Fatty acid degradation_Homo sapiens_hsa000711.99152918
20Sphingolipid metabolism_Homo sapiens_hsa006001.99040921
21Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.87356854
22Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.85860965
23Selenocompound metabolism_Homo sapiens_hsa004501.83545991
24Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.77596319
25Ovarian steroidogenesis_Homo sapiens_hsa049131.77301894
26Biosynthesis of amino acids_Homo sapiens_hsa012301.75014742
27One carbon pool by folate_Homo sapiens_hsa006701.74583533
28Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.73730071
29Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.73201870
30Histidine metabolism_Homo sapiens_hsa003401.72832557
31Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.69243880
32Chemical carcinogenesis_Homo sapiens_hsa052041.66743357
33Phenylalanine metabolism_Homo sapiens_hsa003601.66176565
34Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.63089917
35PPAR signaling pathway_Homo sapiens_hsa033201.62679018
36Peroxisome_Homo sapiens_hsa041461.61972099
37Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.61347932
38Staphylococcus aureus infection_Homo sapiens_hsa051501.60382839
39Drug metabolism - other enzymes_Homo sapiens_hsa009831.58184230
40Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.55538365
41Folate biosynthesis_Homo sapiens_hsa007901.52212273
42beta-Alanine metabolism_Homo sapiens_hsa004101.47961628
43Fatty acid metabolism_Homo sapiens_hsa012121.47798763
44Fatty acid biosynthesis_Homo sapiens_hsa000611.46219969
45Glycerophospholipid metabolism_Homo sapiens_hsa005641.45483960
46Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.39569774
47Butanoate metabolism_Homo sapiens_hsa006501.39049905
48Propanoate metabolism_Homo sapiens_hsa006401.38490690
49Retinol metabolism_Homo sapiens_hsa008301.38276542
50Vascular smooth muscle contraction_Homo sapiens_hsa042701.34902085
51Carbon metabolism_Homo sapiens_hsa012001.31251176
52Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.31019676
53Choline metabolism in cancer_Homo sapiens_hsa052311.30278766
54Cysteine and methionine metabolism_Homo sapiens_hsa002701.29761992
55Fat digestion and absorption_Homo sapiens_hsa049751.29525954
56Circadian rhythm_Homo sapiens_hsa047101.29458163
57Long-term depression_Homo sapiens_hsa047301.22677591
58Pyruvate metabolism_Homo sapiens_hsa006201.22312817
59Bile secretion_Homo sapiens_hsa049761.19627009
60Arginine and proline metabolism_Homo sapiens_hsa003301.19340729
61Steroid hormone biosynthesis_Homo sapiens_hsa001401.17087535
62Tyrosine metabolism_Homo sapiens_hsa003501.16827109
63Sulfur relay system_Homo sapiens_hsa041221.16113508
64Glutathione metabolism_Homo sapiens_hsa004801.15662051
65Vitamin digestion and absorption_Homo sapiens_hsa049771.08635560
66Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.07525029
67Steroid biosynthesis_Homo sapiens_hsa001001.06371972
68Phosphatidylinositol signaling system_Homo sapiens_hsa040701.04538176
69Notch signaling pathway_Homo sapiens_hsa043301.00919580
70Ras signaling pathway_Homo sapiens_hsa040141.00642590
71Lysine degradation_Homo sapiens_hsa003100.98499385
72Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.97948706
73Fatty acid elongation_Homo sapiens_hsa000620.97896118
74Sphingolipid signaling pathway_Homo sapiens_hsa040710.97469119
75alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.96092172
76Pentose phosphate pathway_Homo sapiens_hsa000300.93273264
77Renal cell carcinoma_Homo sapiens_hsa052110.92013203
78Starch and sucrose metabolism_Homo sapiens_hsa005000.90733968
79Dorso-ventral axis formation_Homo sapiens_hsa043200.89126970
80Linoleic acid metabolism_Homo sapiens_hsa005910.88993524
81Pancreatic cancer_Homo sapiens_hsa052120.87799691
82Phospholipase D signaling pathway_Homo sapiens_hsa040720.86770619
83Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.86517197
84ABC transporters_Homo sapiens_hsa020100.86396898
85Mismatch repair_Homo sapiens_hsa034300.85409385
86Inositol phosphate metabolism_Homo sapiens_hsa005620.84032583
87Insulin signaling pathway_Homo sapiens_hsa049100.83977300
88Endocytosis_Homo sapiens_hsa041440.82677836
89Pertussis_Homo sapiens_hsa051330.82527907
90Glioma_Homo sapiens_hsa052140.82348587
91Platelet activation_Homo sapiens_hsa046110.79223619
92Renin secretion_Homo sapiens_hsa049240.77186261
93HIF-1 signaling pathway_Homo sapiens_hsa040660.74376952
94Serotonergic synapse_Homo sapiens_hsa047260.74335954
95Shigellosis_Homo sapiens_hsa051310.73585390
96ErbB signaling pathway_Homo sapiens_hsa040120.73056792
97Bladder cancer_Homo sapiens_hsa052190.71080688
98DNA replication_Homo sapiens_hsa030300.70525355
99Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.69812439
100Chronic myeloid leukemia_Homo sapiens_hsa052200.68503744
101Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.67896032
102Neurotrophin signaling pathway_Homo sapiens_hsa047220.67833605
103AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.67267918
104p53 signaling pathway_Homo sapiens_hsa041150.66559315
105Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.66454612
106Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.65418205
107Glycerolipid metabolism_Homo sapiens_hsa005610.63531519
108Axon guidance_Homo sapiens_hsa043600.63396872
109Salmonella infection_Homo sapiens_hsa051320.63200745
110Fructose and mannose metabolism_Homo sapiens_hsa000510.63076337
111Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.61615444
112Focal adhesion_Homo sapiens_hsa045100.60784419
113Galactose metabolism_Homo sapiens_hsa000520.60458912
114Toxoplasmosis_Homo sapiens_hsa051450.59992076
115Influenza A_Homo sapiens_hsa051640.58602281
116Arachidonic acid metabolism_Homo sapiens_hsa005900.58458215
117Estrogen signaling pathway_Homo sapiens_hsa049150.57106081
118Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.57065513
119Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.56892041
120Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.53667474
121MAPK signaling pathway_Homo sapiens_hsa040100.51934412
122Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.51733864
123Thyroid hormone signaling pathway_Homo sapiens_hsa049190.51517001
124TNF signaling pathway_Homo sapiens_hsa046680.50794848
125Pancreatic secretion_Homo sapiens_hsa049720.50418600
126Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.50117391
127RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.49292977
128Phototransduction_Homo sapiens_hsa047440.48786729
129Rap1 signaling pathway_Homo sapiens_hsa040150.48773056
130Adherens junction_Homo sapiens_hsa045200.48279618
131Tuberculosis_Homo sapiens_hsa051520.47171697
132Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.47091694
133Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.46843200
134Pathways in cancer_Homo sapiens_hsa052000.46707769
135NOD-like receptor signaling pathway_Homo sapiens_hsa046210.44982503
136Hippo signaling pathway_Homo sapiens_hsa043900.44611512
137Leukocyte transendothelial migration_Homo sapiens_hsa046700.42885222
138Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.42307953
139RNA transport_Homo sapiens_hsa030130.41034234
140Regulation of actin cytoskeleton_Homo sapiens_hsa048100.39784761
141Melanogenesis_Homo sapiens_hsa049160.39766837
142Small cell lung cancer_Homo sapiens_hsa052220.39131610
143Basal cell carcinoma_Homo sapiens_hsa052170.37889044
144Tight junction_Homo sapiens_hsa045300.37628077
145Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.36660958
146Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.35595501
147Oxytocin signaling pathway_Homo sapiens_hsa049210.35507337
148Thyroid cancer_Homo sapiens_hsa052160.34187179
149Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.34123340
150Gastric acid secretion_Homo sapiens_hsa049710.33455740
151Metabolic pathways_Homo sapiens_hsa011000.33438502
152Non-small cell lung cancer_Homo sapiens_hsa052230.33266909
153Insulin resistance_Homo sapiens_hsa049310.31717457
154Long-term potentiation_Homo sapiens_hsa047200.30947041
155Central carbon metabolism in cancer_Homo sapiens_hsa052300.29354163
156Maturity onset diabetes of the young_Homo sapiens_hsa049500.28953410
157Sulfur metabolism_Homo sapiens_hsa009200.28650017
158Base excision repair_Homo sapiens_hsa034100.24687129
159Adipocytokine signaling pathway_Homo sapiens_hsa049200.24425835
160Acute myeloid leukemia_Homo sapiens_hsa052210.22635487
161MicroRNAs in cancer_Homo sapiens_hsa052060.21907917
162ECM-receptor interaction_Homo sapiens_hsa045120.21359350
163Proteoglycans in cancer_Homo sapiens_hsa052050.21233753
164AMPK signaling pathway_Homo sapiens_hsa041520.19238316
165mTOR signaling pathway_Homo sapiens_hsa041500.17035869
166Hedgehog signaling pathway_Homo sapiens_hsa043400.16601166
167Ribosome_Homo sapiens_hsa030100.16600027
168Systemic lupus erythematosus_Homo sapiens_hsa053220.15081706
169Hepatitis C_Homo sapiens_hsa051600.12930258

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