TGFBI

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes an RGD-containing protein that binds to type I, II and IV collagens. The RGD motif is found in many extracellular matrix proteins modulating cell adhesion and serves as a ligand recognition sequence for several integrins. This protein plays a role in cell-collagen interactions and may be involved in endochondrial bone formation in cartilage. The protein is induced by transforming growth factor-beta and acts to inhibit cell adhesion. Mutations in this gene are associated with multiple types of corneal dystrophy. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1modulation by organism of immune response of other organism involved in symbiotic interaction (GO:006.55711929
2modulation by organism of defense response of other organism involved in symbiotic interaction (GO:06.55711929
3positive regulation by organism of defense response of other organism involved in symbiotic interact6.55711929
4modulation by symbiont of host immune response (GO:0052553)6.55711929
5positive regulation by symbiont of host defense response (GO:0052509)6.55711929
6modulation by symbiont of host defense response (GO:0052031)6.55711929
7skin morphogenesis (GO:0043589)5.16052697
8antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.92144049
9regulation of interferon-beta biosynthetic process (GO:0045357)4.72001883
10macrophage activation involved in immune response (GO:0002281)4.69818220
11collagen fibril organization (GO:0030199)4.53770735
12substrate-dependent cell migration (GO:0006929)4.46326861
13response to peptidoglycan (GO:0032494)4.44649927
14protein localization to endosome (GO:0036010)4.19439935
15barbed-end actin filament capping (GO:0051016)4.19193040
16response to immune response of other organism involved in symbiotic interaction (GO:0052564)4.16882946
17response to host immune response (GO:0052572)4.16882946
18apoptotic cell clearance (GO:0043277)4.11636338
19protein heterotrimerization (GO:0070208)4.08091303
20virion attachment to host cell (GO:0019062)4.05142297
21adhesion of symbiont to host cell (GO:0044650)4.05142297
22neutrophil activation involved in immune response (GO:0002283)3.94186760
23Golgi transport vesicle coating (GO:0048200)3.93161194
24COPI coating of Golgi vesicle (GO:0048205)3.93161194
25peptidyl-proline hydroxylation (GO:0019511)3.90179648
26negative regulation of smooth muscle cell migration (GO:0014912)3.88398108
27response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.86840777
28response to host (GO:0075136)3.86840777
29response to host defenses (GO:0052200)3.86840777
30protein retention in ER lumen (GO:0006621)3.85054096
31immunoglobulin mediated immune response (GO:0016064)3.84405445
32microglial cell activation (GO:0001774)3.78480222
33collagen metabolic process (GO:0032963)3.78353108
34cellular response to vitamin D (GO:0071305)3.75781215
35chondrocyte proliferation (GO:0035988)3.73168441
36positive regulation of interferon-alpha production (GO:0032727)3.72802993
37maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.72702122
38collagen catabolic process (GO:0030574)3.68311950
39stress fiber assembly (GO:0043149)3.62841034
40sequestering of extracellular ligand from receptor (GO:0035581)3.61523821
41type B pancreatic cell proliferation (GO:0044342)3.60974560
42cellular response to vitamin (GO:0071295)3.60793428
43protein hydroxylation (GO:0018126)3.60250090
44detection of molecule of bacterial origin (GO:0032490)3.59645661
45regulation of cholesterol storage (GO:0010885)3.59556010
46adhesion of symbiont to host (GO:0044406)3.58760578
47positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.58033486
48cell-substrate junction assembly (GO:0007044)3.57400024
49regulation of interferon-alpha production (GO:0032647)3.53476986
50multicellular organismal macromolecule metabolic process (GO:0044259)3.49959256
51regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.46349310
52extracellular matrix disassembly (GO:0022617)3.45651630
53extracellular fibril organization (GO:0043206)3.45516806
54positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)3.44717123
55cellular extravasation (GO:0045123)3.44400890
56dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.44256694
57respiratory burst (GO:0045730)3.40702165
58macrophage activation (GO:0042116)3.38855284
59positive regulation of antigen processing and presentation (GO:0002579)3.35162193
60regulation of dendritic cell antigen processing and presentation (GO:0002604)3.34749904
61multicellular organismal catabolic process (GO:0044243)3.34744548
62positive regulation of blood vessel endothelial cell migration (GO:0043536)3.34117071
63heparan sulfate proteoglycan biosynthetic process (GO:0015012)3.32591543
64fibril organization (GO:0097435)3.31808923
65positive regulation of membrane protein ectodomain proteolysis (GO:0051044)3.28981414
66multicellular organismal metabolic process (GO:0044236)3.28976774
67hemidesmosome assembly (GO:0031581)3.28442480
68cell migration involved in heart development (GO:0060973)3.22274357
69regulation of plasminogen activation (GO:0010755)3.17496745
70negative regulation of interleukin-12 production (GO:0032695)3.15154639
71bone trabecula formation (GO:0060346)3.15076276
72low-density lipoprotein particle clearance (GO:0034383)3.14301941
73glial cell migration (GO:0008347)3.13343049
74production of molecular mediator involved in inflammatory response (GO:0002532)3.12775278
75positive regulation of extracellular matrix organization (GO:1903055)3.11950713
76regulation of mononuclear cell migration (GO:0071675)3.11392450
77extracellular matrix assembly (GO:0085029)3.08776962
78venous blood vessel morphogenesis (GO:0048845)3.08293708
79negative regulation of pathway-restricted SMAD protein phosphorylation (GO:0060394)3.06859178
80pinocytosis (GO:0006907)3.05206416
81cell adhesion mediated by integrin (GO:0033627)3.04606922
82regulation of early endosome to late endosome transport (GO:2000641)3.04364115
83decidualization (GO:0046697)3.03632413
84response to muramyl dipeptide (GO:0032495)3.02638441
85positive regulation of osteoblast proliferation (GO:0033690)3.01164099
86positive regulation of mast cell activation (GO:0033005)2.99498773
87membrane raft organization (GO:0031579)2.96985511
88regulation of macrophage cytokine production (GO:0010935)2.96731426
89positive regulation of cellular amide metabolic process (GO:0034250)2.95973037
90regulation of B cell receptor signaling pathway (GO:0050855)2.94351125
91antigen processing and presentation of endogenous antigen (GO:0019883)2.94214103
92hypotonic response (GO:0006971)2.93344444
93regulation of mast cell degranulation (GO:0043304)2.91663198
94regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.90851198
95positive regulation of macrophage cytokine production (GO:0060907)2.89845223
96wound healing, spreading of cells (GO:0044319)2.88006509
97kidney mesenchyme development (GO:0072074)2.86540003
98positive regulation of axon extension (GO:0045773)2.85842202
99positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610812.84604350
100regulation of integrin activation (GO:0033623)2.84553017
101positive regulation of mast cell activation involved in immune response (GO:0033008)2.83503953
102positive regulation of mast cell degranulation (GO:0043306)2.83503953
103antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.82877638
104antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.82877638
105epithelial cell-cell adhesion (GO:0090136)2.82830656
106regulation of antigen processing and presentation (GO:0002577)2.82594237
107regulation of apoptotic process involved in morphogenesis (GO:1902337)2.82558810
108positive regulation of endothelial cell apoptotic process (GO:2000353)2.82542207
109regulation of extracellular matrix disassembly (GO:0010715)2.82009716
110vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.79273757
111lipopolysaccharide-mediated signaling pathway (GO:0031663)2.78848346
112myeloid cell activation involved in immune response (GO:0002275)2.78172761
113mesodermal cell differentiation (GO:0048333)2.77681053
114regulation of interleukin-8 biosynthetic process (GO:0045414)2.77604118
115regulation of membrane protein ectodomain proteolysis (GO:0051043)2.77428858
116positive regulation of p38MAPK cascade (GO:1900745)2.76648053
117chondroitin sulfate biosynthetic process (GO:0030206)2.76545350
118regulation of mast cell activation involved in immune response (GO:0033006)2.76350835
119keratan sulfate catabolic process (GO:0042340)2.76345447
120mesenchymal-epithelial cell signaling (GO:0060638)2.75953190
121* extracellular matrix organization (GO:0030198)2.75834467
122hydrogen peroxide biosynthetic process (GO:0050665)2.75551082
123I-kappaB phosphorylation (GO:0007252)2.75468602
124positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.75219045
125retina vasculature morphogenesis in camera-type eye (GO:0061299)2.74728390
126* extracellular structure organization (GO:0043062)2.74726310
127positive regulation of toll-like receptor signaling pathway (GO:0034123)2.73854428
128response to laminar fluid shear stress (GO:0034616)2.73164221
129basement membrane organization (GO:0071711)2.72469964
130leukocyte migration involved in inflammatory response (GO:0002523)2.70537481
131actin filament depolymerization (GO:0030042)2.69408767
132positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.68890702
133neutrophil activation (GO:0042119)2.68797426
134negative regulation of nitric oxide biosynthetic process (GO:0045019)2.67781353
135glomerular basement membrane development (GO:0032836)2.67460241
136regulation of monocyte chemotaxis (GO:0090025)2.67190149
137positive regulation of leukocyte degranulation (GO:0043302)2.67168747
138regulation of smooth muscle cell migration (GO:0014910)2.67104829
139granulocyte activation (GO:0036230)2.66361125
140negative regulation of chondrocyte differentiation (GO:0032331)2.65914982
141regulation of vitamin D biosynthetic process (GO:0060556)2.65528855
142negative regulation of granulocyte differentiation (GO:0030853)2.64250792
143response to vitamin D (GO:0033280)2.63904882
144endodermal cell differentiation (GO:0035987)2.63651274
145B cell mediated immunity (GO:0019724)2.61967377
146regulation of metalloenzyme activity (GO:0048552)2.61752708
147negative regulation of protein localization to plasma membrane (GO:1903077)2.61164083
148regulation of leukocyte degranulation (GO:0043300)2.61025692
149cell migration involved in sprouting angiogenesis (GO:0002042)2.60921971
150regulation of integrin-mediated signaling pathway (GO:2001044)2.60047161
151negative regulation of nitric-oxide synthase activity (GO:0051001)2.59681155
152negative regulation of fibrinolysis (GO:0051918)2.59035342
153lipoprotein transport (GO:0042953)2.58002959
154detection of external biotic stimulus (GO:0098581)2.57896350
155cortical actin cytoskeleton organization (GO:0030866)2.57475935
156leukocyte aggregation (GO:0070486)2.56934725
157regulation of macrophage chemotaxis (GO:0010758)2.56885223
158negative regulation of anoikis (GO:2000811)2.56791488
159positive regulation of astrocyte differentiation (GO:0048711)2.56522313
160positive regulation of interferon-beta production (GO:0032728)2.56433985
161embryo implantation (GO:0007566)2.55924023
162substrate adhesion-dependent cell spreading (GO:0034446)2.55769405
163positive regulation of chemokine biosynthetic process (GO:0045080)2.54970182
164tooth mineralization (GO:0034505)2.54794654
165regulation of mast cell activation (GO:0033003)2.54438926
166positive regulation of monocyte chemotaxis (GO:0090026)2.53952038
167glycosphingolipid catabolic process (GO:0046479)2.52577291
168regulation of myeloid leukocyte mediated immunity (GO:0002886)2.52301215
169leukotriene metabolic process (GO:0006691)2.52146490
170membrane protein ectodomain proteolysis (GO:0006509)2.51920918
171germinal center formation (GO:0002467)2.49097573
172positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.48691983
173positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.46549922
174hyaluronan catabolic process (GO:0030214)2.45081565
175neutrophil chemotaxis (GO:0030593)2.44092266
176positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.44086487
177negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.41598135
178regulation of apoptotic cell clearance (GO:2000425)2.41299456
179positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.40429156
180plasma lipoprotein particle clearance (GO:0034381)2.39432273
181lymphocyte chemotaxis (GO:0048247)2.39062220
182response to interferon-alpha (GO:0035455)2.38832973
183complement activation, alternative pathway (GO:0006957)2.37157968
184reactive oxygen species biosynthetic process (GO:1903409)2.37076178
185positive regulation of chemokine production (GO:0032722)2.37058844
186wound healing, spreading of epidermal cells (GO:0035313)2.36445676

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human5.89195600
2BP1_19119308_ChIP-ChIP_Hs578T_Human4.75038067
3IRF8_21731497_ChIP-ChIP_J774_Mouse4.71204995
4IRF8_22096565_ChIP-ChIP_GC-B_Human3.95915177
5* IRF8_27001747_Chip-Seq_BMDM_Mouse3.54711303
6* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.44146782
7* PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse3.29257482
8* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.99914122
9* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.99517586
10NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.96183948
11EGR1_19374776_ChIP-ChIP_THP-1_Human2.60868820
12MYB_21317192_ChIP-Seq_ERMYB_Mouse2.56785214
13TRIM28_21343339_ChIP-Seq_HEK293_Human2.53056242
14SMAD_19615063_ChIP-ChIP_OVARY_Human2.49141396
15RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.47871290
16TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.45008929
17* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.38140395
18BRD4_25478319_ChIP-Seq_HGPS_Human2.34614131
19FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.23058538
20MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.16751552
21STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.14501613
22IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.10430091
23WT1_19549856_ChIP-ChIP_CCG9911_Human2.10035736
24STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.09518589
25RARG_19884340_ChIP-ChIP_MEFs_Mouse2.09386733
26* BRD4_27068464_Chip-Seq_AML-cells_Mouse2.06489550
27STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.00328342
28THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.99889171
29* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.95999631
30CLOCK_20551151_ChIP-Seq_293T_Human1.83880057
31ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.79140765
32STAT6_21828071_ChIP-Seq_BEAS2B_Human1.78853067
33* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.69940085
34* TP53_22127205_ChIP-Seq_IMR90_Human1.69013088
35UBF1/2_26484160_Chip-Seq_HMECs_Human1.68713400
36ELK3_25401928_ChIP-Seq_HUVEC_Human1.67574978
37* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.62867739
38VDR_24787735_ChIP-Seq_THP-1_Human1.62817729
39VDR_24763502_ChIP-Seq_THP-1_Human1.58504721
40STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.57572363
41* ESR1_21235772_ChIP-Seq_MCF-7_Human1.55291522
42PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.53901620
43SMC1_22415368_ChIP-Seq_MEFs_Mouse1.53263788
44SPI1_23127762_ChIP-Seq_K562_Human1.51750886
45RXR_22158963_ChIP-Seq_LIVER_Mouse1.49862318
46* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.49477721
47GATA2_21666600_ChIP-Seq_HMVEC_Human1.49196889
48PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.48800506
49IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.46897145
50UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.46206171
51PPARA_22158963_ChIP-Seq_LIVER_Mouse1.43564051
52LXR_22158963_ChIP-Seq_LIVER_Mouse1.43264206
53P63_26484246_Chip-Seq_KERATINOCYTES_Human1.41004830
54SPI1_23547873_ChIP-Seq_NB4_Human1.40136975
55SCL_19346495_ChIP-Seq_HPC-7_Human1.39957807
56RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.38193042
57ESR2_21235772_ChIP-Seq_MCF-7_Human1.37526635
58VDR_21846776_ChIP-Seq_THP-1_Human1.36138751
59STAT4_19710469_ChIP-ChIP_TH1__Mouse1.36123284
60ATF3_27146783_Chip-Seq_COLON_Human1.35932285
61CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.34086765
62* PU_27001747_Chip-Seq_BMDM_Mouse1.33424297
63SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.33306824
64CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.32997311
65PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.32420059
66* CJUN_26792858_Chip-Seq_BT549_Human1.30785605
67MAF_26560356_Chip-Seq_TH1_Human1.29877457
68HIF1A_21447827_ChIP-Seq_MCF-7_Human1.29418663
69* TP53_18474530_ChIP-ChIP_U2OS_Human1.28963184
70RUNX_20019798_ChIP-Seq_JUKART_Human1.28599952
71GATA1_22025678_ChIP-Seq_K562_Human1.28519808
72KDM2B_26808549_Chip-Seq_SUP-B15_Human1.28359138
73EP300_21415370_ChIP-Seq_HL-1_Mouse1.28017730
74TCF7_22412390_ChIP-Seq_EML_Mouse1.26768133
75SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.26736094
76SOX2_20726797_ChIP-Seq_SW620_Human1.26172378
77TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.25688137
78RUNX1_22412390_ChIP-Seq_EML_Mouse1.24680183
79KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.24525470
80* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.24284300
81* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.24284300
82SOX9_24532713_ChIP-Seq_HFSC_Mouse1.22924228
83FOXO3_23340844_ChIP-Seq_DLD1_Human1.21746804
84TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.21275031
85EGR1_19032775_ChIP-ChIP_M12_Human1.20833506
86* LXR_22292898_ChIP-Seq_THP-1_Human1.19444721
87CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.18356307
88TBX20_22328084_ChIP-Seq_HEART_Mouse1.17798080
89TBX20_22080862_ChIP-Seq_HEART_Mouse1.17798080
90NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.16313218
91NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.15001871
92NFIB_24661679_ChIP-Seq_LUNG_Mouse1.14518137
93CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.12598875
94CDX2_19796622_ChIP-Seq_MESCs_Mouse1.11549447
95TP53_16413492_ChIP-PET_HCT116_Human1.11030371
96SMC3_22415368_ChIP-Seq_MEFs_Mouse1.10834846
97* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.09340517
98SA1_22415368_ChIP-Seq_MEFs_Mouse1.09038886
99RACK7_27058665_Chip-Seq_MCF-7_Human1.08886604
100HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.08094441
101TP53_23651856_ChIP-Seq_MEFs_Mouse1.07213692
102PPAR_26484153_Chip-Seq_NCI-H1993_Human1.07127009
103JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.07015613
104KDM2B_26808549_Chip-Seq_DND41_Human1.06645586
105CDX2_20551321_ChIP-Seq_CACO-2_Human1.06623203
106KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.05868978
107KDM2B_26808549_Chip-Seq_K562_Human1.04295304
108ZNF263_19887448_ChIP-Seq_K562_Human1.04171751
109TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.04023914
110JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.03095571
111FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.01184346
112MYB_26560356_Chip-Seq_TH2_Human1.01020166
113SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.00177574
114KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.99109888
115* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.98940233
116E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.98439019
117CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.97240264
118KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.96955862
119CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.96585562
120P300_27058665_Chip-Seq_ZR-75-30cells_Human0.95609558
121SALL4_18804426_ChIP-ChIP_XEN_Mouse0.95279170
122* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.94999958
123ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.94558376
124GATA2_19941826_ChIP-Seq_K562_Human0.94350627
125TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.93170592
126GATA1_19941826_ChIP-Seq_K562_Human0.92755171
127ZNF217_24962896_ChIP-Seq_MCF-7_Human0.92395716
128EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.92004049
129VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.91672754
130ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.90434604
131NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.90329689
132NRF2_20460467_ChIP-Seq_MEFs_Mouse0.90329689
133CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.90205554
134* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.90040045
135NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.89988100
136* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.89289209
137SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.89196893
138FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.88140914
139MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.82445686

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003436_decreased_susceptibility_to3.60796116
2MP0008438_abnormal_cutaneous_collagen3.29241210
3MP0003303_peritoneal_inflammation3.27326652
4MP0003705_abnormal_hypodermis_morpholog2.85278688
5MP0005058_abnormal_lysosome_morphology2.77134663
6MP0001835_abnormal_antigen_presentation2.63176553
7MP0005275_abnormal_skin_tensile2.60175091
8MP0002419_abnormal_innate_immunity2.52819799
9MP0001533_abnormal_skeleton_physiology2.42196406
10MP0003191_abnormal_cellular_cholesterol2.36784163
11MP0009384_cardiac_valve_regurgitation2.32178102
12MP0009840_abnormal_foam_cell2.31646668
13MP0003724_increased_susceptibility_to2.22851102
14MP0002148_abnormal_hypersensitivity_rea2.20628096
15MP0002254_reproductive_system_inflammat2.20375515
16MP0003300_gastrointestinal_ulcer2.17015684
17MP0005623_abnormal_meninges_morphology2.16680701
18MP0001542_abnormal_bone_strength2.11826193
19MP0003950_abnormal_plasma_membrane2.10430976
20MP0005000_abnormal_immune_tolerance2.04881438
21MP0003566_abnormal_cell_adhesion2.04257202
22MP0009785_altered_susceptibility_to2.02173206
23MP0005025_abnormal_response_to1.98836412
24MP0004510_myositis1.95307682
25MP0000343_altered_response_to1.95083414
26MP0009278_abnormal_bone_marrow1.92169431
27MP0001790_abnormal_immune_system1.84929670
28MP0005387_immune_system_phenotype1.84929670
29MP0004947_skin_inflammation1.81886116
30MP0006082_CNS_inflammation1.78259773
31MP0002452_abnormal_antigen_presenting1.73767900
32MP0003448_altered_tumor_morphology1.73048076
33MP0005076_abnormal_cell_differentiation1.58678573
34MP0005390_skeleton_phenotype1.56819160
35MP0002933_joint_inflammation1.56610555
36MP0002896_abnormal_bone_mineralization1.53425310
37MP0005023_abnormal_wound_healing1.53208053
38MP0005464_abnormal_platelet_physiology1.53067189
39MP0000685_abnormal_immune_system1.52272621
40MP0002877_abnormal_melanocyte_morpholog1.51252522
41MP0002060_abnormal_skin_morphology1.50206310
42MP0005503_abnormal_tendon_morphology1.49710113
43MP0001800_abnormal_humoral_immune1.49322311
44MP0000013_abnormal_adipose_tissue1.46567429
45MP0001851_eye_inflammation1.46328135
46MP0003075_altered_response_to1.45818314
47MP0000604_amyloidosis1.43581491
48MP0002405_respiratory_system_inflammati1.42389892
49MP0002723_abnormal_immune_serum1.42159179
50MP0000465_gastrointestinal_hemorrhage1.41904568
51MP0002998_abnormal_bone_remodeling1.41244753
52MP0001845_abnormal_inflammatory_respons1.38973118
53MP0004858_abnormal_nervous_system1.34063721
54MP0003453_abnormal_keratinocyte_physiol1.33117536
55MP0002295_abnormal_pulmonary_circulatio1.32142058
56MP0001819_abnormal_immune_cell1.31008339
57MP0001958_emphysema1.30675725
58MP0002420_abnormal_adaptive_immunity1.30637302
59MP0005257_abnormal_intraocular_pressure1.30606627
60MP0004272_abnormal_basement_membrane1.28927023
61MP0003172_abnormal_lysosome_physiology1.27072875
62MP0009764_decreased_sensitivity_to1.26861422
63MP0003828_pulmonary_edema1.25710150
64MP0006054_spinal_hemorrhage1.25492815
65MP0000733_abnormal_muscle_development1.25298648
66MP0003279_aneurysm1.25114799
67MP0008469_abnormal_protein_level1.22153308
68MP0005595_abnormal_vascular_smooth1.19997264
69MP0002796_impaired_skin_barrier1.19066308
70MP0010155_abnormal_intestine_physiology1.19007221
71MP0001853_heart_inflammation1.14330602
72MP0002282_abnormal_trachea_morphology1.12453372
73MP0000383_abnormal_hair_follicle1.12030914
74MP0005166_decreased_susceptibility_to1.11856501
75MP0005167_abnormal_blood-brain_barrier1.11510925
76MP0003941_abnormal_skin_development1.09428321
77MP0000767_abnormal_smooth_muscle1.07563121
78MP0002166_altered_tumor_susceptibility1.06958265
79MP0001545_abnormal_hematopoietic_system1.03888119
80MP0005397_hematopoietic_system_phenotyp1.03888119
81MP0004233_abnormal_muscle_weight1.02499710
82MP0003183_abnormal_peptide_metabolism0.99505541
83MP0001216_abnormal_epidermal_layer0.99292837
84MP0003690_abnormal_glial_cell0.99186170
85MP0005165_increased_susceptibility_to0.98280313
86MP0005164_abnormal_response_to0.97976959
87MP0000858_altered_metastatic_potential0.96749837
88MP0008260_abnormal_autophagy0.95339675
89MP0000751_myopathy0.93625117
90MP0001299_abnormal_eye_distance/0.93069921
91MP0010352_gastrointestinal_tract_polyps0.92686653
92MP0010234_abnormal_vibrissa_follicle0.92334660
93MP0002139_abnormal_hepatobiliary_system0.91770518
94MP0002006_tumorigenesis0.91025814
95MP0001243_abnormal_dermal_layer0.90197624
96MP0003795_abnormal_bone_structure0.89611194
97MP0000750_abnormal_muscle_regeneration0.88684811
98MP0005451_abnormal_body_composition0.86774625
99MP0005197_abnormal_uvea_morphology0.86748347
100MP0010678_abnormal_skin_adnexa0.85557025
101MP0002113_abnormal_skeleton_development0.85501289
102MP0009333_abnormal_splenocyte_physiolog0.85178894
103MP0003091_abnormal_cell_migration0.84105241
104MP0009250_abnormal_appendicular_skeleto0.83012689
105MP0000003_abnormal_adipose_tissue0.82004294
106MP0009053_abnormal_anal_canal0.81193724
107MP0000249_abnormal_blood_vessel0.80558286
108MP0005360_urolithiasis0.80468286
109MP0010030_abnormal_orbit_morphology0.80368197
110MP0009763_increased_sensitivity_to0.79869480
111MP0005508_abnormal_skeleton_morphology0.79858236
112MP0000762_abnormal_tongue_morphology0.79703090
113MP0004782_abnormal_surfactant_physiolog0.79022264
114MP0010368_abnormal_lymphatic_system0.78834190
115MP0000759_abnormal_skeletal_muscle0.78621603
116MP0001849_ear_inflammation0.77385466
117* MP0000716_abnormal_immune_system0.76438438
118MP0002098_abnormal_vibrissa_morphology0.75415668
119MP0009931_abnormal_skin_appearance0.75162609
120MP0005671_abnormal_response_to0.75059171
121MP0009780_abnormal_chondrocyte_physiolo0.73179587
122MP0001614_abnormal_blood_vessel0.71358760
123MP0000163_abnormal_cartilage_morphology0.71345009
124MP0010386_abnormal_urinary_bladder0.71229193
125MP0005193_abnormal_anterior_eye0.70304863
126MP0002115_abnormal_skeleton_extremities0.69684374
127MP0002168_other_aberrant_phenotype0.68730085
128MP0000579_abnormal_nail_morphology0.68370017
129MP0001915_intracranial_hemorrhage0.67811054
130MP0000569_abnormal_digit_pigmentation0.67289074
131MP0001879_abnormal_lymphatic_vessel0.67011426
132MP0004883_abnormal_blood_vessel0.65000846
133MP0001191_abnormal_skin_condition0.64774945
134MP0000534_abnormal_ureter_morphology0.64010112
135MP0005388_respiratory_system_phenotype0.63827428
136MP0002133_abnormal_respiratory_system0.63827428
137MP0003329_amyloid_beta_deposits0.62422624
138MP0002128_abnormal_blood_circulation0.61961670
139MP0002108_abnormal_muscle_morphology0.60744042
140MP0005409_darkened_coat_color0.60369191
141MP0004134_abnormal_chest_morphology0.60230597
142MP0003385_abnormal_body_wall0.56932153
143MP0000749_muscle_degeneration0.56906942

Predicted human phenotypes

RankGene SetZ-score
1Systemic lupus erythematosus (HP:0002725)5.55088374
2Recurrent abscess formation (HP:0002722)5.20716937
3Eczematoid dermatitis (HP:0000976)4.90166129
4Recurrent gram-negative bacterial infections (HP:0005420)4.62157822
5Recurrent bacterial skin infections (HP:0005406)4.59522641
6Thick nail (HP:0001805)3.99014618
7Soft skin (HP:0000977)3.83334025
8Increased cerebral lipofuscin (HP:0011813)3.82433037
9Glomerulonephritis (HP:0000099)3.74059656
10Bladder diverticulum (HP:0000015)3.69139754
11Vacuolated lymphocytes (HP:0001922)3.60556336
12Abnormality of dentin (HP:0010299)3.40163799
13Wormian bones (HP:0002645)3.39234681
14Abnormality of macrophages (HP:0004311)3.36501922
15Abnormality of complement system (HP:0005339)3.35562341
16Genu recurvatum (HP:0002816)3.25515443
17Increased neuronal autofluorescent lipopigment (HP:0002074)3.20560311
18Gingivitis (HP:0000230)3.20091753
19Complement deficiency (HP:0004431)3.19117433
20Blue sclerae (HP:0000592)3.18078110
21Osteolytic defects of the phalanges of the hand (HP:0009771)3.11580955
22Osteolytic defects of the hand bones (HP:0009699)3.11580955
23Dysostosis multiplex (HP:0000943)3.01707783
24Myocardial infarction (HP:0001658)2.95701745
25Spinal rigidity (HP:0003306)2.94014913
26Myositis (HP:0100614)2.93752876
27Peritonitis (HP:0002586)2.92202624
28Orchitis (HP:0100796)2.91138140
29Type 1 muscle fiber predominance (HP:0003803)2.90266611
30Neonatal short-limb short stature (HP:0008921)2.82736582
31Prostate neoplasm (HP:0100787)2.80809079
32Axonal loss (HP:0003447)2.80534329
33Periodontitis (HP:0000704)2.80507488
34Pustule (HP:0200039)2.79481431
35Mediastinal lymphadenopathy (HP:0100721)2.72943908
36Hematochezia (HP:0002573)2.72187828
37Cerebral aneurysm (HP:0004944)2.71934013
38Premature rupture of membranes (HP:0001788)2.68289247
39Nephritis (HP:0000123)2.63370214
40Cervical subluxation (HP:0003308)2.62956792
41Aortic regurgitation (HP:0001659)2.60679891
42Biconcave vertebral bodies (HP:0004586)2.59707138
43Protrusio acetabuli (HP:0003179)2.58175816
44Mucopolysacchariduria (HP:0008155)2.55834197
45Urinary glycosaminoglycan excretion (HP:0003541)2.55834197
46Disinhibition (HP:0000734)2.55483946
47Recurrent skin infections (HP:0001581)2.54882707
48Spontaneous hematomas (HP:0007420)2.54790031
49Vertebral compression fractures (HP:0002953)2.54600180
50Mitral stenosis (HP:0001718)2.49776775
51Thin bony cortex (HP:0002753)2.48984218
52Autoimmune thrombocytopenia (HP:0001973)2.47126545
53Elbow flexion contracture (HP:0002987)2.45546034
54Elevated erythrocyte sedimentation rate (HP:0003565)2.45155265
55Hyperextensible skin (HP:0000974)2.43866488
56Short nail (HP:0001799)2.43770474
57Alopecia of scalp (HP:0002293)2.40831376
58Atrophic scars (HP:0001075)2.40032904
59Amyloidosis (HP:0011034)2.39454822
60Abnormality of the acetabulum (HP:0003170)2.37194544
61Bowel diverticulosis (HP:0005222)2.36183058
62Joint laxity (HP:0001388)2.35208997
63Mitral regurgitation (HP:0001653)2.34551499
64Aortic dissection (HP:0002647)2.34120795
65Abnormality of the lumbar spine (HP:0100712)2.32713058
66Abnormality of polysaccharide metabolism (HP:0011012)2.32711141
67Abnormality of glycosaminoglycan metabolism (HP:0004371)2.32711141
68Abnormality of mucopolysaccharide metabolism (HP:0011020)2.32711141
69Milia (HP:0001056)2.30473538
70Obstructive lung disease (HP:0006536)2.23015152
71Chronic obstructive pulmonary disease (HP:0006510)2.23015152
72Nuclear cataract (HP:0100018)2.20894930
73Epiphyseal dysplasia (HP:0002656)2.20735535
74Arterial tortuosity (HP:0005116)2.20012277
75Abnormal delivery (HP:0001787)2.19147886
76Urticaria (HP:0001025)2.18552880
77Abnormality of liposaccharide metabolism (HP:0010968)2.17054466
78Abnormality of glycosphingolipid metabolism (HP:0004343)2.17054466
79Abnormality of glycolipid metabolism (HP:0010969)2.17054466
80Femoral bowing (HP:0002980)2.16683788
81Cellulitis (HP:0100658)2.15514019
82Plantar hyperkeratosis (HP:0007556)2.14440124
83Aortic valve stenosis (HP:0001650)2.13983452
84Aneurysm (HP:0002617)2.13024208
85Loss of speech (HP:0002371)2.12760534
86Natal tooth (HP:0000695)2.12244795
87Increased connective tissue (HP:0009025)2.11851377
88Increased IgE level (HP:0003212)2.11790765
89Mildly elevated creatine phosphokinase (HP:0008180)2.10694194
90Achilles tendon contracture (HP:0001771)2.09208167
91Cardiovascular calcification (HP:0011915)2.08236752
92Interstitial pulmonary disease (HP:0006530)2.07365962
93Ulnar bowing (HP:0003031)2.07057512
94Joint hemorrhage (HP:0005261)2.03842875
95Shallow orbits (HP:0000586)2.01626333
96Increased variability in muscle fiber diameter (HP:0003557)2.00920866
97Generalized amyotrophy (HP:0003700)1.98550013
98Mitral valve prolapse (HP:0001634)1.97782596
99Wrist flexion contracture (HP:0001239)1.97333062
100Aortic aneurysm (HP:0004942)1.96500830
101Upper limb amyotrophy (HP:0009129)1.96384388
102Distal upper limb amyotrophy (HP:0007149)1.96384388
103Vascular tortuosity (HP:0004948)1.95082319
104Abnormality of skull ossification (HP:0002703)1.93324325
105Spondylolisthesis (HP:0003302)1.92976987
106Optic neuritis (HP:0100653)1.92883466
107Retrobulbar optic neuritis (HP:0100654)1.92883466
108Disproportionate tall stature (HP:0001519)1.92771852
109Ankle contracture (HP:0006466)1.92655330
110Absent frontal sinuses (HP:0002688)1.91073464
111Recurrent fungal infections (HP:0002841)1.90610133
112Cupped ribs (HP:0000887)1.89139831
113Broad metatarsal (HP:0001783)1.87723086
114Abnormality of the Achilles tendon (HP:0005109)1.87222910
115Follicular hyperkeratosis (HP:0007502)1.86933867
116Palmoplantar hyperkeratosis (HP:0000972)1.84299302
117Broad face (HP:0000283)1.84054767
118Tibial bowing (HP:0002982)1.83751637
119Flared iliac wings (HP:0002869)1.82212481
120Long toe (HP:0010511)1.82198126
121Coxa vara (HP:0002812)1.81397588
122Delayed closure of the anterior fontanelle (HP:0001476)1.80519681
123Abnormality of the distal phalanges of the toes (HP:0010182)1.80392979
124Congenital glaucoma (HP:0001087)1.78582738
125Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.78527042
126Spinal cord lesions (HP:0100561)1.78313326
127Syringomyelia (HP:0003396)1.78313326
128Neurofibrillary tangles (HP:0002185)1.78249710
129Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.76037345
130Overgrowth (HP:0001548)1.75444119
131Ectopia lentis (HP:0001083)1.74975343
132Dilatation of the ascending aorta (HP:0005111)1.74193367
133Abnormality of skeletal muscle fiber size (HP:0012084)1.73901191
134Pathologic fracture (HP:0002756)1.73410168
135Fragile skin (HP:0001030)1.73301269
136Delayed cranial suture closure (HP:0000270)1.72378933
137Hyperacusis (HP:0010780)1.72102352
138Nonimmune hydrops fetalis (HP:0001790)1.72044001
139Arterial thrombosis (HP:0004420)1.71793184
140Round ear (HP:0100830)1.71213927
141Thoracic kyphosis (HP:0002942)1.70125959
142Neoplasm of head and neck (HP:0012288)1.69459834
143Esophageal neoplasm (HP:0100751)1.69459834
144Camptodactyly of toe (HP:0001836)1.69324204
145Inguinal hernia (HP:0000023)1.68901165
146Hallux valgus (HP:0001822)1.68445765
147Ovoid vertebral bodies (HP:0003300)1.67619367
148Premature loss of primary teeth (HP:0006323)1.66793026
149Mild short stature (HP:0003502)1.66778925
150Flat acetabular roof (HP:0003180)1.66380801
151Palmar hyperkeratosis (HP:0010765)1.65990540
152Osteoarthritis (HP:0002758)1.65792526
153Xanthomatosis (HP:0000991)1.65504000
154Asymmetric septal hypertrophy (HP:0001670)1.65307387
155Joint stiffness (HP:0001387)1.65137468
156Abnormality of the vasculature of the conjunctiva (HP:0008054)1.64893471
157Skin ulcer (HP:0200042)1.63478628
158Slender build (HP:0001533)1.63211328

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN14.33781764
2BLK3.11074246
3TYK22.88114672
4TGFBR22.83773094
5TESK12.60457538
6TRIB32.57484011
7LIMK12.50872604
8TBK12.49939203
9TTN2.47684687
10EPHB12.38612498
11MST1R2.36449258
12MAP3K32.31292617
13MYLK2.17662084
14NTRK12.10806137
15RIPK42.08728773
16LATS22.04789544
17MAP3K142.01204432
18KIT2.00059177
19RIPK11.98947348
20CSK1.78437263
21PKN21.74746563
22IRAK41.73278798
23MAP4K11.71791720
24MAP2K31.68768326
25CDC42BPA1.66466521
26PTK61.62065471
27CAMK1D1.58451059
28STK101.52422443
29LRRK21.49982197
30FGR1.47035600
31IKBKE1.44417312
32ARAF1.44290380
33EPHA31.42956791
34JAK11.38347282
35PRPF4B1.37977007
36DDR21.36725578
37BMX1.36415787
38JAK31.31490660
39FGFR41.28210852
40CSF1R1.22958927
41TAOK21.22644060
42IRAK31.21809076
43PRKD21.21219542
44HCK1.19137467
45IKBKB1.19043851
46JAK21.08013168
47NEK91.07935311
48FGFR31.07853068
49ZAP701.07391135
50MATK1.06536015
51RPS6KA41.05714318
52MET1.05379644
53TRPM71.04691572
54LMTK21.01910941
55MAP3K101.01343108
56STK381.01220004
57MAP3K60.96713008
58PAK40.96324731
59FES0.95251241
60ERBB40.94676266
61BTK0.93848421
62ICK0.92193876
63NME20.90432873
64EPHB20.87314775
65CAMK1G0.86897364
66MAP3K110.82834100
67STK30.81187137
68TAOK30.80131417
69PIM20.79082230
70EPHA20.78704663
71ILK0.75048920
72DMPK0.74999401
73KDR0.74216096
74CHUK0.72942829
75MOS0.72788744
76LYN0.72290151
77CDK60.72186732
78LCK0.71921479
79MAP3K10.71612912
80PDGFRA0.70537718
81ABL20.70460738
82MST40.70330294
83STK240.70329448
84RPS6KA20.70324793
85PIK3CG0.69929157
86ROCK10.69355168
87MUSK0.69219726
88LATS10.67329746
89MELK0.67181202
90ROCK20.66849917
91MAP3K20.65594153
92EGFR0.65352631
93DAPK30.64978951
94PAK60.63720646
95KSR10.63094131
96PIM10.61823890
97GRK70.61194382
98PRKG20.60769498
99SYK0.60237680
100GSK3A0.59905321
101PRKCD0.59747802
102MTOR0.58758526
103MAP3K80.58410752
104RPS6KA60.57916019
105ITK0.57328664
106MAPKAPK20.55083708
107MAP2K20.55054436
108PBK0.55022737
109ABL10.54863272
110GRK60.54820486
111MARK30.54202230
112RPS6KC10.53968446
113RPS6KL10.53968446
114TGFBR10.53770387
115PAK20.52412479
116SIK10.51880661
117PTK20.51406910
118PDGFRB0.51381088
119SMG10.49808452
120MAPKAPK30.49580098
121TESK20.49460513
122KSR20.49181668
123PRKCH0.49042864
124CLK10.47505805
125PTK2B0.47023798
126ERBB30.46609424
127MAP3K130.46148137
128FLT30.43394021
129TEC0.42844464
130SCYL20.42673219
131PAK10.42386678
132CAMKK20.42154176
133MAPK70.42109223
134MAP3K90.39769290
135PDPK10.38629622
136INSR0.35317392
137MAPK110.32620170
138SRC0.32022409
139BRAF0.31398023
140MAP3K120.28215229

Predicted pathways (KEGG)

RankGene SetZ-score
1Staphylococcus aureus infection_Homo sapiens_hsa051504.66252603
2Leishmaniasis_Homo sapiens_hsa051402.96629569
3Malaria_Homo sapiens_hsa051442.63956788
4Glycosaminoglycan degradation_Homo sapiens_hsa005312.40072003
5Lysosome_Homo sapiens_hsa041422.37595238
6Osteoclast differentiation_Homo sapiens_hsa043802.36235156
7Pertussis_Homo sapiens_hsa051332.31641472
8Complement and coagulation cascades_Homo sapiens_hsa046102.27546763
9Other glycan degradation_Homo sapiens_hsa005112.17134279
10Toll-like receptor signaling pathway_Homo sapiens_hsa046202.15011854
11Legionellosis_Homo sapiens_hsa051342.14336928
12Tuberculosis_Homo sapiens_hsa051522.03757215
13Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.93115297
14Phagosome_Homo sapiens_hsa041451.89302219
15Caffeine metabolism_Homo sapiens_hsa002321.73955178
16Toxoplasmosis_Homo sapiens_hsa051451.68491738
17Amoebiasis_Homo sapiens_hsa051461.56008886
18ECM-receptor interaction_Homo sapiens_hsa045121.54340793
19NF-kappa B signaling pathway_Homo sapiens_hsa040641.52869875
20Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.52214045
21Salmonella infection_Homo sapiens_hsa051321.50591086
22Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.45231416
23B cell receptor signaling pathway_Homo sapiens_hsa046621.43237082
24Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.42382075
25Galactose metabolism_Homo sapiens_hsa000521.42142459
26TNF signaling pathway_Homo sapiens_hsa046681.41103610
27Leukocyte transendothelial migration_Homo sapiens_hsa046701.40316874
28Shigellosis_Homo sapiens_hsa051311.38130374
29Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.37697303
30Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.31744511
31Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.26685735
32NOD-like receptor signaling pathway_Homo sapiens_hsa046211.26468665
33AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.26405935
34Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.25622891
35Vibrio cholerae infection_Homo sapiens_hsa051101.24015748
36Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.23961443
37Dilated cardiomyopathy_Homo sapiens_hsa054141.21820310
38Antigen processing and presentation_Homo sapiens_hsa046121.20200970
39Influenza A_Homo sapiens_hsa051641.20012130
40Measles_Homo sapiens_hsa051621.18794458
41Rheumatoid arthritis_Homo sapiens_hsa053231.15089423
42Proteoglycans in cancer_Homo sapiens_hsa052051.14655766
43Hematopoietic cell lineage_Homo sapiens_hsa046401.13997310
44Apoptosis_Homo sapiens_hsa042101.13860751
45Focal adhesion_Homo sapiens_hsa045101.09022538
46Central carbon metabolism in cancer_Homo sapiens_hsa052301.08993552
47Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.08811048
48Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.08188546
49Chemokine signaling pathway_Homo sapiens_hsa040621.05043689
50Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.04688495
51Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.98797077
52Renin-angiotensin system_Homo sapiens_hsa046140.97165009
53Jak-STAT signaling pathway_Homo sapiens_hsa046300.95540768
54Platelet activation_Homo sapiens_hsa046110.92627650
55Viral myocarditis_Homo sapiens_hsa054160.91689340
56RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.91563644
57Mineral absorption_Homo sapiens_hsa049780.89537943
58Chronic myeloid leukemia_Homo sapiens_hsa052200.89477281
59Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.88386626
60Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.87840795
61Hepatitis C_Homo sapiens_hsa051600.86965858
62Protein digestion and absorption_Homo sapiens_hsa049740.86804633
63Hepatitis B_Homo sapiens_hsa051610.84778023
64Adherens junction_Homo sapiens_hsa045200.82923133
65Prion diseases_Homo sapiens_hsa050200.82890114
66Pancreatic cancer_Homo sapiens_hsa052120.82430398
67N-Glycan biosynthesis_Homo sapiens_hsa005100.82402025
68Herpes simplex infection_Homo sapiens_hsa051680.80652462
69Intestinal immune network for IgA production_Homo sapiens_hsa046720.80122079
70Regulation of actin cytoskeleton_Homo sapiens_hsa048100.76338612
71Pentose phosphate pathway_Homo sapiens_hsa000300.76241194
72Small cell lung cancer_Homo sapiens_hsa052220.75350575
73Melanoma_Homo sapiens_hsa052180.74325598
74Histidine metabolism_Homo sapiens_hsa003400.74089749
75Acute myeloid leukemia_Homo sapiens_hsa052210.73227092
76p53 signaling pathway_Homo sapiens_hsa041150.72326151
77African trypanosomiasis_Homo sapiens_hsa051430.72181321
78Fructose and mannose metabolism_Homo sapiens_hsa000510.71608546
79Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.71511909
80Pentose and glucuronate interconversions_Homo sapiens_hsa000400.69821224
81Sulfur metabolism_Homo sapiens_hsa009200.69605967
82Adipocytokine signaling pathway_Homo sapiens_hsa049200.65341754
83Fat digestion and absorption_Homo sapiens_hsa049750.62322447
84Insulin resistance_Homo sapiens_hsa049310.62193512
85Graft-versus-host disease_Homo sapiens_hsa053320.61508647
86Phospholipase D signaling pathway_Homo sapiens_hsa040720.60391870
87PPAR signaling pathway_Homo sapiens_hsa033200.59862025
88Glioma_Homo sapiens_hsa052140.59632424
89Asthma_Homo sapiens_hsa053100.59536771
90Notch signaling pathway_Homo sapiens_hsa043300.58612071
91Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.57074203
92Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.56257078
93Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.55763261
94Sphingolipid metabolism_Homo sapiens_hsa006000.55560049
95Endocytosis_Homo sapiens_hsa041440.53797048
96VEGF signaling pathway_Homo sapiens_hsa043700.53726492
97Starch and sucrose metabolism_Homo sapiens_hsa005000.53407635
98Bladder cancer_Homo sapiens_hsa052190.53170170
99Neurotrophin signaling pathway_Homo sapiens_hsa047220.52762285
100MicroRNAs in cancer_Homo sapiens_hsa052060.50974149
101HIF-1 signaling pathway_Homo sapiens_hsa040660.50884342
102Transcriptional misregulation in cancer_Homo sapiens_hsa052020.50229217
103Non-small cell lung cancer_Homo sapiens_hsa052230.49274227
104GnRH signaling pathway_Homo sapiens_hsa049120.48521415
105Primary bile acid biosynthesis_Homo sapiens_hsa001200.46836967
106Hippo signaling pathway_Homo sapiens_hsa043900.46046821
107TGF-beta signaling pathway_Homo sapiens_hsa043500.45424394
108Sphingolipid signaling pathway_Homo sapiens_hsa040710.44493738
109ABC transporters_Homo sapiens_hsa020100.44123102
110Prostate cancer_Homo sapiens_hsa052150.43487833
111Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.41767708
112Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.39623017
113Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.38472094
114Renal cell carcinoma_Homo sapiens_hsa052110.37928426
115Arachidonic acid metabolism_Homo sapiens_hsa005900.36566536
116PI3K-Akt signaling pathway_Homo sapiens_hsa041510.35898763
117mTOR signaling pathway_Homo sapiens_hsa041500.35844811
118Prolactin signaling pathway_Homo sapiens_hsa049170.35617716
119Gap junction_Homo sapiens_hsa045400.34546343
120Rap1 signaling pathway_Homo sapiens_hsa040150.32707632
121Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.31038979
122Pathways in cancer_Homo sapiens_hsa052000.30491548
123HTLV-I infection_Homo sapiens_hsa051660.29125346
124Vitamin digestion and absorption_Homo sapiens_hsa049770.29007821

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