TFPI

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a Kunitz-type serine protease inhibitor that regulates the tissue factor (TF)-dependent pathway of blood coagulation. The coagulation process initiates with the formation of a factor VIIa-TF complex, which proteolytically activates additional proteases (factors IX and X) and ultimately leads to the formation of a fibrin clot. The product of this gene inhibits the activated factor X and VIIa-TF proteases in an autoregulatory loop. Inhibition of the encoded protein restores hemostasis in animal models of hemophilia. This gene encodes multiple protein isoforms that differ in their inhibitory activity, specificity and cellular localization. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cellular response to vascular endothelial growth factor stimulus (GO:0035924)8.08435414
2interleukin-6-mediated signaling pathway (GO:0070102)7.96391705
3positive regulation of protein kinase C signaling (GO:0090037)7.27769747
4positive regulation of tyrosine phosphorylation of Stat1 protein (GO:0042511)6.30631435
5endothelium development (GO:0003158)6.11367592
6negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)5.90130379
7vascular endothelial growth factor receptor signaling pathway (GO:0048010)5.68445311
8positive regulation vascular endothelial growth factor production (GO:0010575)5.52323669
9positive regulation of astrocyte differentiation (GO:0048711)5.36010562
10positive regulation of vasculogenesis (GO:2001214)5.32615392
11sexual reproduction (GO:0019953)5.19935119
12leukocyte tethering or rolling (GO:0050901)5.19404162
13morphogenesis of an endothelium (GO:0003159)5.15481831
14endothelial tube morphogenesis (GO:0061154)5.15481831
15potassium ion import (GO:0010107)5.09885217
16sprouting angiogenesis (GO:0002040)4.91720712
17blood vessel endothelial cell migration (GO:0043534)4.76664892
18transcytosis (GO:0045056)4.72285896
19hyaluronan catabolic process (GO:0030214)4.65609019
20retina vasculature morphogenesis in camera-type eye (GO:0061299)4.61472183
21basement membrane organization (GO:0071711)4.58155669
22regulation of vascular endothelial growth factor production (GO:0010574)4.48273988
23leukocyte migration involved in inflammatory response (GO:0002523)4.46041677
24establishment of endothelial barrier (GO:0061028)4.24916627
25mRNA transcription from RNA polymerase II promoter (GO:0042789)3.95597057
26regulation of tyrosine phosphorylation of Stat1 protein (GO:0042510)3.94525799
27high-density lipoprotein particle remodeling (GO:0034375)3.92079002
28positive regulation of transforming growth factor beta receptor signaling pathway (GO:0030511)3.89241579
29cell migration involved in sprouting angiogenesis (GO:0002042)3.87620269
30reverse cholesterol transport (GO:0043691)3.87189463
31regulation of cell migration involved in sprouting angiogenesis (GO:0090049)3.86513675
32blood vessel maturation (GO:0001955)3.84171383
33cellular response to interleukin-6 (GO:0071354)3.81365280
34regulation of vasculogenesis (GO:2001212)3.79523142
35negative regulation of sodium ion transport (GO:0010766)3.75115004
36embryonic heart tube development (GO:0035050)3.74811370
37negative regulation of complement activation (GO:0045916)3.71814338
38negative regulation of platelet activation (GO:0010544)3.69488377
39regulation of protein activation cascade (GO:2000257)3.67916631
40positive regulation of endothelial cell migration (GO:0010595)3.67154616
41regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030947)3.62662111
42negative regulation of blood vessel endothelial cell migration (GO:0043537)3.62176674
43regulation of complement activation (GO:0030449)3.58921286
44regulation of protein kinase C signaling (GO:0090036)3.57968005
45negative regulation of endothelial cell apoptotic process (GO:2000352)3.52580032
46UDP-N-acetylglucosamine metabolic process (GO:0006047)3.51927343
47heart trabecula formation (GO:0060347)3.49193999
48endothelial cell differentiation (GO:0045446)3.45566850
49tryptophan catabolic process (GO:0006569)3.44766533
50indole-containing compound catabolic process (GO:0042436)3.44766533
51indolalkylamine catabolic process (GO:0046218)3.44766533
52mRNA transcription (GO:0009299)3.40901326
53positive regulation of endothelial cell proliferation (GO:0001938)3.39437169
54surfactant homeostasis (GO:0043129)3.35267642
55regulation of hippo signaling (GO:0035330)3.33568126
56plasma lipoprotein particle remodeling (GO:0034369)3.33132792
57protein-lipid complex remodeling (GO:0034368)3.33132792
58macromolecular complex remodeling (GO:0034367)3.33132792
59vasculogenesis (GO:0001570)3.32670686
60triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.31589137
61cholesterol efflux (GO:0033344)3.30966386
62peptidyl-tyrosine autophosphorylation (GO:0038083)3.30900177
63plasma lipoprotein particle assembly (GO:0034377)3.30330042
64chondrocyte proliferation (GO:0035988)3.27217457
65regulation of establishment or maintenance of cell polarity (GO:0032878)3.23913965
66regulation of pigment cell differentiation (GO:0050932)3.20892851
67cell migration involved in heart development (GO:0060973)3.20722306
68negative regulation of protein localization to cell surface (GO:2000009)3.20570351
69positive regulation of cardiac muscle hypertrophy (GO:0010613)3.16120105
70positive regulation of muscle hypertrophy (GO:0014742)3.16120105
71regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)3.15251537
72intestinal cholesterol absorption (GO:0030299)3.15127240
73regulation of endothelial cell migration (GO:0010594)3.13208852
74phospholipid homeostasis (GO:0055091)3.12163576
75response to interleukin-6 (GO:0070741)3.11416845
76definitive hemopoiesis (GO:0060216)3.09732767
77regulation of establishment of cell polarity (GO:2000114)3.09359145
78negative regulation of lipase activity (GO:0060192)3.05111921
79neuron projection extension involved in neuron projection guidance (GO:1902284)3.05059472
80axon extension involved in axon guidance (GO:0048846)3.05059472
81regulation of fibrinolysis (GO:0051917)3.03536067
82interkinetic nuclear migration (GO:0022027)3.02933796
83ovulation from ovarian follicle (GO:0001542)3.02413478
84negative regulation of protein activation cascade (GO:2000258)3.01225126
85regulation of endothelial cell proliferation (GO:0001936)3.01099526
86low-density lipoprotein particle remodeling (GO:0034374)2.99575349
87vasculature development (GO:0001944)2.98606735
88protein heterotrimerization (GO:0070208)2.98399211
89endothelial cell migration (GO:0043542)2.97825851
90aromatic amino acid family catabolic process (GO:0009074)2.96936145
91positive regulation of epithelial cell migration (GO:0010634)2.96549317
92regulation of tight junction assembly (GO:2000810)2.96128933
93positive regulation of developmental pigmentation (GO:0048087)2.94768898
94negative regulation of vascular permeability (GO:0043116)2.94531082
95patterning of blood vessels (GO:0001569)2.94471700
96regulation of sarcomere organization (GO:0060297)2.94425522
97very-low-density lipoprotein particle assembly (GO:0034379)2.94278778
98regulation of endothelial cell apoptotic process (GO:2000351)2.93640633
99endocardial cushion development (GO:0003197)2.91810178
1003-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.90065593
101purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.90065593
102plasma lipoprotein particle organization (GO:0071827)2.89447710
103tryptophan metabolic process (GO:0006568)2.89444509
104cellular response to ethanol (GO:0071361)2.89440852
105renal tubule morphogenesis (GO:0061333)2.88397496
106indolalkylamine metabolic process (GO:0006586)2.87324861
107nephron epithelium morphogenesis (GO:0072088)2.83785545
108nephron tubule morphogenesis (GO:0072078)2.83785545
109endothelial cell development (GO:0001885)2.83448416
110detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.82344509
111positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.81610506
112negative regulation of endothelial cell migration (GO:0010596)2.80329005
113substrate adhesion-dependent cell spreading (GO:0034446)2.79560392
114thrombin receptor signaling pathway (GO:0070493)2.79268681
115kynurenine metabolic process (GO:0070189)2.78984266
116blood coagulation, intrinsic pathway (GO:0007597)2.76791298
117negative regulation of nitric-oxide synthase activity (GO:0051001)2.76447304
118regulation of non-canonical Wnt signaling pathway (GO:2000050)2.75313464
119protein-lipid complex assembly (GO:0065005)2.74236844
120venous blood vessel morphogenesis (GO:0048845)2.73337559
121phagocytosis, recognition (GO:0006910)2.72479891
122pathway-restricted SMAD protein phosphorylation (GO:0060389)2.72375938
123peptidyl-glutamic acid carboxylation (GO:0017187)2.70571041
124protein carboxylation (GO:0018214)2.70571041
125monoubiquitinated protein deubiquitination (GO:0035520)2.69361839
126flavonoid metabolic process (GO:0009812)2.69111324
127heme transport (GO:0015886)2.68019992
128cellular response to sterol (GO:0036315)2.67373145
129negative regulation of fibrinolysis (GO:0051918)2.67203610
130regulation of cholesterol esterification (GO:0010872)2.66702874
131cellular response to thyroid hormone stimulus (GO:0097067)2.66056826
132establishment of protein localization to Golgi (GO:0072600)2.64788380
133phospholipid translocation (GO:0045332)2.64383267
134lipid translocation (GO:0034204)2.64383267
135negative regulation of axon extension involved in axon guidance (GO:0048843)2.64175459
136negative regulation of coagulation (GO:0050819)2.63669686
137vitamin catabolic process (GO:0009111)2.63510479
138fat-soluble vitamin catabolic process (GO:0042363)2.63510479
139atrial cardiac muscle cell action potential (GO:0086014)2.62756331
140Notch signaling involved in heart development (GO:0061314)2.62536912
141protein-lipid complex subunit organization (GO:0071825)2.61329138
142cholesterol transport (GO:0030301)2.60993685
143sterol transport (GO:0015918)2.60993685
144endothelial cell proliferation (GO:0001935)2.60946348
145regulation of integrin-mediated signaling pathway (GO:2001044)2.60850154
146regulation of epithelial cell migration (GO:0010632)2.60596785
147lipoprotein metabolic process (GO:0042157)2.58869764
148trabecula morphogenesis (GO:0061383)2.58436494
149regulation of integrin activation (GO:0033623)2.58398354
150negative regulation of humoral immune response (GO:0002921)2.58284560
151trabecula formation (GO:0060343)2.57499577
152acylglycerol homeostasis (GO:0055090)2.57163044
153triglyceride homeostasis (GO:0070328)2.57163044
154sphingoid metabolic process (GO:0046519)2.56530073
155negative regulation of angiogenesis (GO:0016525)2.56512391
156signal peptide processing (GO:0006465)2.56162137
157phospholipid efflux (GO:0033700)2.55853677
158glomerular basement membrane development (GO:0032836)2.53813472
159negative regulation of blood coagulation (GO:0030195)2.52822442
160negative regulation of hemostasis (GO:1900047)2.52822442
161arginine catabolic process (GO:0006527)2.52199857
162regulation of blood vessel endothelial cell migration (GO:0043535)2.52110203
163cell adhesion mediated by integrin (GO:0033627)2.52094159
164positive regulation of cell junction assembly (GO:1901890)2.50979980
165positive regulation of focal adhesion assembly (GO:0051894)2.50979980
166tyrosine phosphorylation of STAT protein (GO:0007260)2.50075073
167angiogenesis (GO:0001525)2.49642391
168wound healing, spreading of epidermal cells (GO:0035313)2.48639755
169negative regulation of thymocyte apoptotic process (GO:0070244)2.47660903
170bundle of His cell to Purkinje myocyte communication (GO:0086069)2.47293633
171negative regulation of telomerase activity (GO:0051974)2.46952934
172angiogenesis involved in wound healing (GO:0060055)2.46542653
173negative regulation of blood vessel morphogenesis (GO:2000181)2.46053154
174L-phenylalanine catabolic process (GO:0006559)2.43126959
175erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.43126959
176tonic smooth muscle contraction (GO:0014820)2.43004707
177sulfation (GO:0051923)2.42167938
178fibrinolysis (GO:0042730)2.41395996
179negative regulation of calcium ion transport into cytosol (GO:0010523)2.41035408
180lymph vessel development (GO:0001945)12.4833971
181lymphangiogenesis (GO:0001946)11.0047954
182vascular endothelial growth factor signaling pathway (GO:0038084)10.3501364

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human9.03160125
2E2F7_22180533_ChIP-Seq_HELA_Human4.15490407
3KLF2_18264089_ChIP-ChIP_MESCs_Mouse4.08343530
4KLF5_18264089_ChIP-ChIP_MESCs_Mouse4.08343530
5KLF4_18264089_ChIP-ChIP_MESCs_Mouse4.08343530
6PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.67173214
7CLOCK_20551151_ChIP-Seq_293T_Human3.34990587
8GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.27064723
9CEBPD_23245923_ChIP-Seq_MEFs_Mouse3.07424331
10GBX2_23144817_ChIP-Seq_PC3_Human3.04576156
11NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.81055079
12TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.77814325
13VDR_22108803_ChIP-Seq_LS180_Human2.64941111
14POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.56344740
15ZFP57_27257070_Chip-Seq_ESCs_Mouse2.51413440
16GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.49582000
17* POU3F2_20337985_ChIP-ChIP_501MEL_Human2.44713106
18RARG_19884340_ChIP-ChIP_MEFs_Mouse2.37990319
19* SALL4_18804426_ChIP-ChIP_XEN_Mouse2.37055280
20EGR1_19374776_ChIP-ChIP_THP-1_Human2.35265705
21STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.34758487
22* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human2.32109372
23ZNF274_21170338_ChIP-Seq_K562_Hela2.24007052
24SALL1_21062744_ChIP-ChIP_HESCs_Human2.22946323
25TRIM28_21343339_ChIP-Seq_HEK293_Human2.21321912
26* GATA2_21666600_ChIP-Seq_HMVEC_Human2.12818222
27ZIC3_20872845_ChIP-ChIP_MESCs_Mouse2.08513253
28CDX2_19796622_ChIP-Seq_MESCs_Mouse2.07396444
29P300_19829295_ChIP-Seq_ESCs_Human2.06005938
30STAT3_1855785_ChIP-Seq_MESCs_Mouse2.05077409
31HIF1A_21447827_ChIP-Seq_MCF-7_Human2.02215267
32ELK3_25401928_ChIP-Seq_HUVEC_Human2.00034897
33SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.99640779
34EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.99447618
35PIAS1_25552417_ChIP-Seq_VCAP_Human1.97655325
36FLI1_27457419_Chip-Seq_LIVER_Mouse1.95480240
37TP53_16413492_ChIP-PET_HCT116_Human1.93741517
38SMAD_19615063_ChIP-ChIP_OVARY_Human1.93723621
39PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.85437718
40STAT3_23295773_ChIP-Seq_U87_Human1.84891055
41ESR1_20079471_ChIP-ChIP_T-47D_Human1.83370750
42IGF1R_20145208_ChIP-Seq_DFB_Human1.81983767
43SMAD4_21799915_ChIP-Seq_A2780_Human1.80105889
44* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.78955930
45ER_23166858_ChIP-Seq_MCF-7_Human1.76393799
46TP63_17297297_ChIP-ChIP_HaCaT_Human1.74040669
47PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.73556304
48TAF15_26573619_Chip-Seq_HEK293_Human1.73440141
49HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.73323533
50EWS_26573619_Chip-Seq_HEK293_Human1.71606164
51CTBP2_25329375_ChIP-Seq_LNCAP_Human1.71009136
52EGR1_23403033_ChIP-Seq_LIVER_Mouse1.68226830
53PCGF2_27294783_Chip-Seq_ESCs_Mouse1.68176826
54BCAT_22108803_ChIP-Seq_LS180_Human1.66720830
55NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.65738053
56ESR1_21235772_ChIP-Seq_MCF-7_Human1.61227441
57* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.61066196
58NR3C1_21868756_ChIP-Seq_MCF10A_Human1.60221452
59UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.59792285
60RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.59330664
61SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.59136877
62HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.58176768
63FUS_26573619_Chip-Seq_HEK293_Human1.57519661
64CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.57314143
65TCF4_23295773_ChIP-Seq_U87_Human1.53753235
66PPAR_26484153_Chip-Seq_NCI-H1993_Human1.53256444
67* NRF2_20460467_ChIP-Seq_MEFs_Mouse1.52417764
68* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.52417764
69EP300_21415370_ChIP-Seq_HL-1_Mouse1.51774930
70SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.51449924
71AR_21909140_ChIP-Seq_LNCAP_Human1.51427909
72MYC_18555785_ChIP-Seq_MESCs_Mouse1.51372677
73TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.50779277
74EZH2_27294783_Chip-Seq_NPCs_Mouse1.50579498
75* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.49635894
76TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.49197361
77FOXM1_23109430_ChIP-Seq_U2OS_Human1.48766918
78OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.48355880
79* FOXM1_26456572_ChIP-Seq_MCF-7_Human1.46913330
80MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.45748374
81CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.44273997
82NELFA_20434984_ChIP-Seq_ESCs_Mouse1.43077312
83TCF4_22108803_ChIP-Seq_LS180_Human1.41772040
84CTBP1_25329375_ChIP-Seq_LNCAP_Human1.40623226
85CDX2_22108803_ChIP-Seq_LS180_Human1.40261440
86* AR_25329375_ChIP-Seq_VCAP_Human1.39559549
87AHR_22903824_ChIP-Seq_MCF-7_Human1.38925157
88* SMAD3_21741376_ChIP-Seq_EPCs_Human1.37011164
89* AR_21572438_ChIP-Seq_LNCaP_Human1.36220900
90RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.35810597
91PCGF2_27294783_Chip-Seq_NPCs_Mouse1.34243397
92NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.34135743
93IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.33938694
94CBP_20019798_ChIP-Seq_JUKART_Human1.33938694
95SUZ12_27294783_Chip-Seq_NPCs_Mouse1.33474437
96SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.33088831
97SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.33088831
98* FOXA2_19822575_ChIP-Seq_HepG2_Human1.33040188
99CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.32928626
100TP53_18474530_ChIP-ChIP_U2OS_Human1.32596021
101TOP2B_26459242_ChIP-Seq_MCF-7_Human1.31936916
102* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.31351513
103NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.30660054
104ARNT_22903824_ChIP-Seq_MCF-7_Human1.29229417
105ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.29176144
106MYC_19079543_ChIP-ChIP_MESCs_Mouse1.29035875
107RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.28856644
108ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.28720977
109FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.28048030
110LXR_22158963_ChIP-Seq_LIVER_Mouse1.27685719
111FLI1_21867929_ChIP-Seq_TH2_Mouse1.27101647
112ESR2_21235772_ChIP-Seq_MCF-7_Human1.26922245
113MYB_21317192_ChIP-Seq_ERMYB_Mouse1.26101057
114DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.24363588
115RUNX2_22187159_ChIP-Seq_PCA_Human1.23895483
116* NANOG_18555785_Chip-Seq_ESCs_Mouse1.23627322
117* SOX2_18555785_ChIP-Seq_MESCs_Mouse1.22670044
118SOX2_19829295_ChIP-Seq_ESCs_Human1.21975581
119NANOG_19829295_ChIP-Seq_ESCs_Human1.21975581
120THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.21465106
121TCF3_18692474_ChIP-Seq_MEFs_Mouse1.21040532
122* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.20978491
123TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.20825872
124NANOG_18555785_ChIP-Seq_MESCs_Mouse1.20546899
125KLF5_20875108_ChIP-Seq_MESCs_Mouse1.20054852
126SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.19445311
127NFE2_27457419_Chip-Seq_LIVER_Mouse1.17505746
128PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.17464585
129SMAD3_21741376_ChIP-Seq_HESCs_Human1.15977446
130EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.15682862
131SMAD4_21741376_ChIP-Seq_EPCs_Human1.14898956
132NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.13891565
133CRX_20693478_ChIP-Seq_RETINA_Mouse1.13656561
134E2F1_18555785_Chip-Seq_ESCs_Mouse1.12904628
135STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.11938424
136RXR_22108803_ChIP-Seq_LS180_Human1.11612301
137TBX20_22328084_ChIP-Seq_HEART_Mouse1.11356989
138TBX20_22080862_ChIP-Seq_HEART_Mouse1.11356989
139FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.11128456
140* TCF4_18268006_ChIP-ChIP_LS174T_Human1.10407313
141ZNF263_19887448_ChIP-Seq_K562_Human1.10357174
142* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.10070080
143TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.09684847
144* SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.09504408
145* FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.09212927
146GATA4_21415370_ChIP-Seq_HL-1_Mouse1.09043720
147RBPJ_22232070_ChIP-Seq_NCS_Mouse1.08790450
148ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.08198414
149CTNNB1_20460455_ChIP-Seq_HCT116_Human1.07732870
150EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.07080393
151OCT4_21477851_ChIP-Seq_ESCs_Mouse1.06914644
152TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05551153
153FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.05495135
154* P53_22387025_ChIP-Seq_ESCs_Mouse1.05438212
155KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.04699928
156* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.04689099
157POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.04605285
158TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04605285
159ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.04264748
160* SOX2_20726797_ChIP-Seq_SW620_Human1.03660411
161GATA1_19941826_ChIP-Seq_K562_Human1.01740576
162KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.01718255
163ESR1_15608294_ChIP-ChIP_MCF-7_Human1.01252703
164NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.01200644
165SOX17_20123909_ChIP-Seq_XEN_Mouse0.99935445
166TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.99895252
167CJUN_26792858_Chip-Seq_BT549_Human0.98874573
168SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.97900087
169JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.97702755
170WT1_19549856_ChIP-ChIP_CCG9911_Human0.96981024
171E2F4_17652178_ChIP-ChIP_JURKAT_Human0.96312139
172MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.93851046
173GATA1_22025678_ChIP-Seq_K562_Human0.93545393
174BRD4_25478319_ChIP-Seq_HGPS_Human0.93406539
175* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.92832916
176MYC_19030024_ChIP-ChIP_MESCs_Mouse0.90712150
177ATF3_27146783_Chip-Seq_COLON_Human0.90681579
178OCT4_18692474_ChIP-Seq_MEFs_Mouse0.88525682
179EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.87110807
180NCOR1_26117541_ChIP-Seq_K562_Human0.86937480
181KDM2B_26808549_Chip-Seq_SUP-B15_Human0.86458753
182* GATA1_22383799_ChIP-Seq_G1ME_Mouse0.84528799
183* SOX2_18692474_ChIP-Seq_MEFs_Mouse0.82823325
184RACK7_27058665_Chip-Seq_MCF-7_Human0.81172611
185TFEB_21752829_ChIP-Seq_HELA_Human0.80906099
186HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.80359892
187* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.79367980

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010368_abnormal_lymphatic_system7.46826716
2MP0003195_calcinosis6.56988994
3MP0001879_abnormal_lymphatic_vessel5.97476159
4MP0003724_increased_susceptibility_to5.21969944
5MP0000013_abnormal_adipose_tissue4.92841517
6MP0003950_abnormal_plasma_membrane4.72945000
7MP0008004_abnormal_stomach_pH4.56699313
8MP0004272_abnormal_basement_membrane3.85874360
9MP0008438_abnormal_cutaneous_collagen3.04758897
10MP0003300_gastrointestinal_ulcer2.71239297
11MP0004215_abnormal_myocardial_fiber2.67130586
12MP0005085_abnormal_gallbladder_physiolo2.59447775
13MP0005360_urolithiasis2.40196443
14MP0003252_abnormal_bile_duct2.38272865
15MP0001851_eye_inflammation2.25674954
16MP0002168_other_aberrant_phenotype2.25448665
17MP0005365_abnormal_bile_salt2.22453540
18MP0004084_abnormal_cardiac_muscle2.16271773
19MP0010329_abnormal_lipoprotein_level2.07963243
20MP0002138_abnormal_hepatobiliary_system2.07961297
21MP0000003_abnormal_adipose_tissue2.03346367
22MP0003868_abnormal_feces_composition2.02874554
23MP0000465_gastrointestinal_hemorrhage1.89834265
24MP0001666_abnormal_nutrient_absorption1.84917659
25MP0002139_abnormal_hepatobiliary_system1.77851900
26MP0003828_pulmonary_edema1.77332620
27MP0003566_abnormal_cell_adhesion1.72745292
28MP0003279_aneurysm1.72038801
29* MP0006054_spinal_hemorrhage1.69042855
30MP0000569_abnormal_digit_pigmentation1.65769154
31MP0008875_abnormal_xenobiotic_pharmacok1.64214160
32MP0005409_darkened_coat_color1.63826767
33MP0005395_other_phenotype1.62822533
34MP0003705_abnormal_hypodermis_morpholog1.59772559
35MP0005167_abnormal_blood-brain_barrier1.59309065
36MP0003045_fibrosis1.57059543
37MP0005551_abnormal_eye_electrophysiolog1.56999089
38MP0009780_abnormal_chondrocyte_physiolo1.56454814
39MP0005670_abnormal_white_adipose1.51154665
40MP0005187_abnormal_penis_morphology1.49011806
41MP0003890_abnormal_embryonic-extraembry1.43596478
42MP0004808_abnormal_hematopoietic_stem1.39637754
43MP0000767_abnormal_smooth_muscle1.37813136
44MP0000343_altered_response_to1.37730774
45MP0004130_abnormal_muscle_cell1.36194748
46MP0008775_abnormal_heart_ventricle1.35637152
47MP0005084_abnormal_gallbladder_morpholo1.35054620
48MP0001986_abnormal_taste_sensitivity1.34329351
49MP0005623_abnormal_meninges_morphology1.32846185
50MP0003646_muscle_fatigue1.30820946
51MP0005410_abnormal_fertilization1.30522690
52MP0003385_abnormal_body_wall1.28634415
53MP0003567_abnormal_fetal_cardiomyocyte1.26965216
54MP0002925_abnormal_cardiovascular_devel1.26314256
55MP0004043_abnormal_pH_regulation1.24060256
56MP0005164_abnormal_response_to1.23225008
57MP0005367_renal/urinary_system_phenotyp1.23095824
58MP0000516_abnormal_urinary_system1.23095824
59MP0002396_abnormal_hematopoietic_system1.22766440
60MP0005275_abnormal_skin_tensile1.20926376
61MP0010630_abnormal_cardiac_muscle1.20861421
62MP0001873_stomach_inflammation1.20554645
63* MP0002128_abnormal_blood_circulation1.20109626
64MP0006138_congestive_heart_failure1.18960714
65MP0001614_abnormal_blood_vessel1.15405269
66* MP0002086_abnormal_extraembryonic_tissu1.14762353
67MP0001243_abnormal_dermal_layer1.13560455
68* MP0002088_abnormal_embryonic_growth/wei1.12654900
69MP0002876_abnormal_thyroid_physiology1.12434368
70MP0002127_abnormal_cardiovascular_syste1.12056706
71MP0005385_cardiovascular_system_phenoty1.11788522
72MP0001544_abnormal_cardiovascular_syste1.11788522
73MP0005023_abnormal_wound_healing1.11336888
74MP0004147_increased_porphyrin_level1.11327188
75MP0005375_adipose_tissue_phenotype1.05174532
76MP0000230_abnormal_systemic_arterial1.02238703
77* MP0003984_embryonic_growth_retardation1.02036557
78MP0002295_abnormal_pulmonary_circulatio1.01031809
79MP0000249_abnormal_blood_vessel0.99715941
80MP0003943_abnormal_hepatobiliary_system0.99472405
81MP0004883_abnormal_blood_vessel0.98681297
82MP0005595_abnormal_vascular_smooth0.98267925
83MP0003136_yellow_coat_color0.96641096
84MP0002933_joint_inflammation0.96316914
85MP0005332_abnormal_amino_acid0.95555504
86MP0001958_emphysema0.94330436
87MP0008057_abnormal_DNA_replication0.93451060
88MP0004036_abnormal_muscle_relaxation0.93238019
89* MP0000266_abnormal_heart_morphology0.93076234
90MP0003937_abnormal_limbs/digits/tail_de0.92013052
91MP0005503_abnormal_tendon_morphology0.91435041
92MP0002928_abnormal_bile_duct0.91184287
93MP0002938_white_spotting0.90918938
94MP0001533_abnormal_skeleton_physiology0.90859655
95MP0003123_paternal_imprinting0.90245199
96* MP0001915_intracranial_hemorrhage0.89330668
97MP0003091_abnormal_cell_migration0.88953248
98MP0002972_abnormal_cardiac_muscle0.88386597
99MP0005171_absent_coat_pigmentation0.87152497
100* MP0001672_abnormal_embryogenesis/_devel0.86442258
101* MP0005380_embryogenesis_phenotype0.86442258
102MP0002254_reproductive_system_inflammat0.84047436
103MP0003011_delayed_dark_adaptation0.83866024
104MP0009697_abnormal_copulation0.83420575
105MP0010352_gastrointestinal_tract_polyps0.83389248
106MP0003718_maternal_effect0.83032096
107MP0005165_increased_susceptibility_to0.81026522
108MP0005330_cardiomyopathy0.79018687
109MP0003935_abnormal_craniofacial_develop0.78268897
110MP0001697_abnormal_embryo_size0.77759480
111MP0001501_abnormal_sleep_pattern0.75538231
112MP0004264_abnormal_extraembryonic_tissu0.75412872
113MP0005220_abnormal_exocrine_pancreas0.74931183
114MP0001485_abnormal_pinna_reflex0.74796010
115MP0002118_abnormal_lipid_homeostasis0.74147925
116MP0000427_abnormal_hair_cycle0.74144080
117MP0005408_hypopigmentation0.74141126
118MP0000639_abnormal_adrenal_gland0.73932834
119MP0003941_abnormal_skin_development0.73728934
120MP0005508_abnormal_skeleton_morphology0.73602910
121* MP0001784_abnormal_fluid_regulation0.73212258
122MP0002089_abnormal_postnatal_growth/wei0.73164713
123MP0003122_maternal_imprinting0.72432707
124MP0001542_abnormal_bone_strength0.71361794
125MP0004085_abnormal_heartbeat0.71178405
126MP0003119_abnormal_digestive_system0.70808482
127MP0002160_abnormal_reproductive_system0.70522399
128MP0005253_abnormal_eye_physiology0.70239658
129MP0003221_abnormal_cardiomyocyte_apopto0.70107709
130MP0001756_abnormal_urination0.70016186
131MP0001324_abnormal_eye_pigmentation0.68929748
132MP0004019_abnormal_vitamin_homeostasis0.67941120
133MP0000462_abnormal_digestive_system0.67052379
134MP0005195_abnormal_posterior_eye0.66721830
135MP0001299_abnormal_eye_distance/0.66233438
136MP0008007_abnormal_cellular_replicative0.66207557
137MP0009763_increased_sensitivity_to0.66157882
138MP0003303_peritoneal_inflammation0.63646054
139MP0005620_abnormal_muscle_contractility0.63073492
140MP0002896_abnormal_bone_mineralization0.61837549
141MP0000598_abnormal_liver_morphology0.61630123
142MP0009278_abnormal_bone_marrow0.61228790
143MP0004087_abnormal_muscle_fiber0.60677597
144MP0001661_extended_life_span0.60061581
145MP0000647_abnormal_sebaceous_gland0.59604049
146MP0004484_altered_response_of0.59567497
147MP0009250_abnormal_appendicular_skeleto0.59557341
148MP0004185_abnormal_adipocyte_glucose0.59437073
149MP0005666_abnormal_adipose_tissue0.58856249
150MP0001191_abnormal_skin_condition0.58344857
151MP0002282_abnormal_trachea_morphology0.58331381
152MP0000750_abnormal_muscle_regeneration0.57739995
153MP0000383_abnormal_hair_follicle0.57657076
154MP0001175_abnormal_lung_morphology0.56727190
155MP0005376_homeostasis/metabolism_phenot0.56606872
156MP0009046_muscle_twitch0.56216312
157MP0003121_genomic_imprinting0.55993244
158MP0001730_embryonic_growth_arrest0.55775482
159MP0002060_abnormal_skin_morphology0.52893023
160MP0005390_skeleton_phenotype0.52454127
161MP0009384_cardiac_valve_regurgitation0.52141718
162MP0002332_abnormal_exercise_endurance0.51933026

Predicted human phenotypes

RankGene SetZ-score
1Capillary hemangiomas (HP:0005306)6.50634839
2Broad metatarsal (HP:0001783)6.18833745
3Short hallux (HP:0010109)6.16983304
4Aplasia/Hypoplasia of the hallux (HP:0008362)5.83958253
5Congenital, generalized hypertrichosis (HP:0004540)4.90980468
6Ventricular tachycardia (HP:0004756)4.72175068
7Premature rupture of membranes (HP:0001788)4.59115350
8Hypoplastic ischia (HP:0003175)4.58391220
9Lymphedema (HP:0001004)4.29993965
10Abnormality of the ischium (HP:0003174)4.13535171
11Lymphangioma (HP:0100764)4.07821781
12Protrusio acetabuli (HP:0003179)3.96018102
13Preaxial foot polydactyly (HP:0001841)3.91114601
14Aplasia/Hypoplasia of the pubic bone (HP:0009104)3.89443939
15Hypobetalipoproteinemia (HP:0003563)3.89273336
16Cerebral aneurysm (HP:0004944)3.86041987
17Hematochezia (HP:0002573)3.61199218
18Prominent supraorbital ridges (HP:0000336)3.59109447
19Hyperventilation (HP:0002883)3.56013908
20Right ventricular cardiomyopathy (HP:0011663)3.49229470
21Abnormality of the peritoneum (HP:0002585)3.46277448
22Prolonged partial thromboplastin time (HP:0003645)3.41831296
23Abnormality of the common coagulation pathway (HP:0010990)3.41044206
24Spontaneous hematomas (HP:0007420)3.30621615
25Absent eyelashes (HP:0000561)3.29316556
26Cardiomegaly (HP:0001640)3.16463222
27Absent toe (HP:0010760)3.15880841
28Pancreatic cysts (HP:0001737)3.11252998
29Deep venous thrombosis (HP:0002625)3.10130989
30Myocardial infarction (HP:0001658)3.04976598
31Aortic dissection (HP:0002647)3.04520500
32Aplasia/Hypoplasia of the tibia (HP:0005772)3.02446258
33Hypolipoproteinemia (HP:0010981)3.01939088
34Aortic aneurysm (HP:0004942)3.01133444
35Polycythemia (HP:0001901)2.98920901
36Spontaneous abortion (HP:0005268)2.98387651
37Acanthocytosis (HP:0001927)2.98372772
38Large for gestational age (HP:0001520)2.94933917
39Keratoconus (HP:0000563)2.94502253
40Increased corneal curvature (HP:0100692)2.94502253
41Bicuspid aortic valve (HP:0001647)2.92459794
42Menorrhagia (HP:0000132)2.76173951
43Abnormality of the renal cortex (HP:0011035)2.75614547
44Venous abnormality (HP:0002624)2.75038827
45Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.72772540
46Enlarged kidneys (HP:0000105)2.72308343
47Chronic hepatic failure (HP:0100626)2.68398197
48Hypophosphatemic rickets (HP:0004912)2.64394474
49Lipoatrophy (HP:0100578)2.62241872
50Complement deficiency (HP:0004431)2.62130951
51Pancreatic fibrosis (HP:0100732)2.60968815
52Hydroxyprolinuria (HP:0003080)2.60430472
53Abnormality of proline metabolism (HP:0010907)2.60430472
54Venous insufficiency (HP:0005293)2.59686743
55Epidermoid cyst (HP:0200040)2.58725199
56Abnormality of the nasal septum (HP:0000419)2.57631928
57Esophageal varix (HP:0002040)2.57242644
58True hermaphroditism (HP:0010459)2.55610824
59Joint hemorrhage (HP:0005261)2.53983166
60Low anterior hairline (HP:0000294)2.50497246
61Atrial fibrillation (HP:0005110)2.49773000
62Gaze-evoked nystagmus (HP:0000640)2.46176859
63Fair hair (HP:0002286)2.45539213
64Vascular tortuosity (HP:0004948)2.44474074
65Exercise-induced muscle cramps (HP:0003710)2.44260176
66Aneurysm (HP:0002617)2.44221049
67Absent eyebrow (HP:0002223)2.43806181
68Abnormality of the sella turcica (HP:0002679)2.43146711
69Intrahepatic cholestasis (HP:0001406)2.42629680
70Potter facies (HP:0002009)2.41506992
71Facial shape deformation (HP:0011334)2.41506992
72Supraventricular arrhythmia (HP:0005115)2.40741120
73Genetic anticipation (HP:0003743)2.38899589
74Accelerated skeletal maturation (HP:0005616)2.34663708
75Soft skin (HP:0000977)2.34503327
76Increased connective tissue (HP:0009025)2.34370138
77Pigmentary retinal degeneration (HP:0001146)2.33770190
78Cervical subluxation (HP:0003308)2.33762798
79Periorbital edema (HP:0100539)2.31938199
80Abnormality of the wing of the ilium (HP:0011867)2.31932572
81Abnormality of the nasal mucosa (HP:0000433)2.31712897
82Abnormality of the renal medulla (HP:0100957)2.31193509
83Hypothermia (HP:0002045)2.30505283
84Glomerulonephritis (HP:0000099)2.28686810
85Abnormality of the intrinsic pathway (HP:0010989)2.28019696
86Conjunctival telangiectasia (HP:0000524)2.27122235
87Ovoid vertebral bodies (HP:0003300)2.26751720
88Ankle contracture (HP:0006466)2.26630014
89Shallow orbits (HP:0000586)2.26014121
90Facial edema (HP:0000282)2.25601548
91Large hands (HP:0001176)2.25269892
92Abnormality of the vasculature of the conjunctiva (HP:0008054)2.24712967
93Primary atrial arrhythmia (HP:0001692)2.24519685
94Arterial tortuosity (HP:0005116)2.23333218
95Cystic liver disease (HP:0006706)2.21145787
96Toxemia of pregnancy (HP:0100603)2.19658997
97Supraventricular tachycardia (HP:0004755)2.18762425
98Platyspondyly (HP:0000926)2.17411996
99Molar tooth sign on MRI (HP:0002419)2.15712778
100Abnormality of midbrain morphology (HP:0002418)2.15712778
101Tubular atrophy (HP:0000092)2.15217899
102Bladder diverticulum (HP:0000015)2.15179964
103Broad hallux (HP:0010055)2.13716325
104Hyperlipoproteinemia (HP:0010980)2.12850245
105Exotropia (HP:0000577)2.11790943
106Submucous cleft hard palate (HP:0000176)2.10418827
107Attenuation of retinal blood vessels (HP:0007843)2.09990593
108Cone-rod dystrophy (HP:0000548)2.09453645
109Decreased central vision (HP:0007663)2.09280562
110Reduced subcutaneous adipose tissue (HP:0003758)2.08631511
111Blue sclerae (HP:0000592)2.08175607
112Hypoalphalipoproteinemia (HP:0003233)2.07980576
113Palpebral edema (HP:0100540)2.07552878
114Abnormality of the pubic bones (HP:0003172)2.07383786
115Peritonitis (HP:0002586)2.07083375
116Protruding tongue (HP:0010808)2.06934451
117Dilated cardiomyopathy (HP:0001644)2.06384738
118Renal cortical cysts (HP:0000803)2.04052612
119Conjugated hyperbilirubinemia (HP:0002908)2.03845061
120Coxa valga (HP:0002673)2.02279463
121Congenital stationary night blindness (HP:0007642)2.00829390
122Aplasia/Hypoplasia of the tongue (HP:0010295)2.00095866
123Nonimmune hydrops fetalis (HP:0001790)11.7234768
124Nephronophthisis (HP:0000090)1.97149181
125Portal hypertension (HP:0001409)1.93742242
126Osteomalacia (HP:0002749)1.93667731
127Broad toe (HP:0001837)1.93372768
128Chondrocalcinosis (HP:0000934)1.93033054
129Central scotoma (HP:0000603)1.92698317
130Hyporeflexia of lower limbs (HP:0002600)1.91796184
131Bulbous nose (HP:0000414)1.90842861
132Congenital hepatic fibrosis (HP:0002612)1.90416393
133Mesangial abnormality (HP:0001966)1.90307219
134Widely spaced teeth (HP:0000687)1.88773415
135Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.87248855
136Abnormality of alanine metabolism (HP:0010916)1.87248855
137Hyperalaninemia (HP:0003348)1.87248855
138Scotoma (HP:0000575)1.86445634
139Thrombocytosis (HP:0001894)1.86076990
140Facial diplegia (HP:0001349)1.85792644
141Medial flaring of the eyebrow (HP:0010747)1.85012018
142Purpura (HP:0000979)1.84778979
143Cardiovascular calcification (HP:0011915)1.84680142
144Hypoplastic iliac wings (HP:0002866)1.84389139
145Cupped ear (HP:0000378)1.84035087
146Hypotrichosis (HP:0001006)1.83861974
147Xanthomatosis (HP:0000991)1.83821429
148Disproportionate short-trunk short stature (HP:0003521)1.82947810
149Bifid tongue (HP:0010297)1.82756972
150Short chin (HP:0000331)1.81859689
151Polygenic inheritance (HP:0010982)1.80594160
152Poikilocytosis (HP:0004447)1.80479561
153Papillary thyroid carcinoma (HP:0002895)1.80461377
154Abnormality of macular pigmentation (HP:0008002)1.77961917
155Vertebral compression fractures (HP:0002953)1.76368839
156Abnormality of Sharpey fibers (HP:0100685)1.76236704
157Muscle fiber splitting (HP:0003555)1.74935582
158Abnormality of the hepatic vasculature (HP:0006707)1.74211253
159Ileus (HP:0002595)1.73372741
160Hypercholesterolemia (HP:0003124)1.72225375
161Mucosal telangiectasiae (HP:0100579)1.69985157
162Increased number of teeth (HP:0011069)1.68952230
163Genital tract atresia (HP:0001827)1.68455426
164Reticulocytopenia (HP:0001896)1.67808549
165Asymmetric septal hypertrophy (HP:0001670)1.67303285
166Abnormality of glutamine family amino acid metabolism (HP:0010902)1.66720160
167Diastasis recti (HP:0001540)1.65905487
168Wormian bones (HP:0002645)1.65621118
169Febrile seizures (HP:0002373)1.65404927
170Short foot (HP:0001773)1.64974494
171Long eyelashes (HP:0000527)1.64855385
172Visceral angiomatosis (HP:0100761)1.64259505
173Selective tooth agenesis (HP:0001592)1.62339780
174Vascular calcification (HP:0004934)1.62323744
175Hemangiomatosis (HP:0007461)1.61182468
176Abnormality of the pericardium (HP:0001697)1.61121732
177Thin skin (HP:0000963)1.60656594
178Low posterior hairline (HP:0002162)1.60222168
179Spinal rigidity (HP:0003306)1.57236001
180Abnormality of skeletal muscle fiber size (HP:0012084)1.55832142

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK7.47613560
2TIE16.95015847
3TGFBR23.05977567
4TGFBR12.81910957
5AKT32.23443525
6LATS12.09478107
7STK392.08266396
8KDR13.2394577
9NUAK11.89937678
10ERN11.89686228
11MKNK21.87348659
12PKN21.80443999
13EIF2AK31.62295154
14TNIK1.61687140
15WNK41.57959837
16NLK1.55197199
17ADRBK21.52674518
18PIK3CG1.47933302
19JAK31.45881771
20CASK1.37708583
21FLT31.35939198
22PLK21.33020544
23STK38L1.30906933
24WNK31.27635021
25MAPK131.26760807
26JAK11.24953549
27ADRBK11.18620622
28INSRR1.18517847
29NTRK31.17590679
30BCR1.09380209
31CAMK41.08894521
32SCYL21.05898809
33MELK1.04389900
34PRKAA21.02308201
35OXSR11.02074328
36MAP4K21.00290057
37WEE11.00191369
38FGFR30.98456630
39TRIM280.95066107
40PRKCE0.92095118
41TTN0.92014538
42GRK10.91949304
43PNCK0.89730238
44PTK2B0.87434963
45PTK60.86780171
46FGFR20.86208509
47FER0.80314365
48MYLK0.78843705
49RPS6KB20.78611297
50PAK40.77814796
51TAOK30.77737927
52STK100.76914706
53PDGFRA0.75201247
54SGK20.71553913
55MAP2K30.70949793
56MET0.68965502
57MKNK10.68819710
58MAP3K110.68350908
59MAP3K20.68213236
60RPS6KA40.67895007
61PDGFRB0.66655844
62PINK10.66458097
63ROCK10.65932153
64LRRK20.64787614
65JAK20.63394078
66STK380.62766625
67TAF10.62408052
68RIPK10.61244694
69TRIB30.60690378
70EPHB10.59860713
71BRSK20.59613546
72PRKG20.58861520
73MAPKAPK30.56486130
74BLK0.55519706
75MAP2K10.54168262
76PDK20.54035172
77NEK10.51966077
78WNK10.51912466
79MUSK0.51432033
80EPHB20.49174366
81CDK90.48837786
82IRAK10.48638527
83MAP3K80.48081681
84PTK20.48011618
85TEC0.47851777
86CAMK1G0.47532556
87ACVR1B0.46914183
88ERBB40.46424252
89PRKG10.46202613
90ERBB20.45050877
91RET0.44874040
92CDC70.43927839
93MAPKAPK50.43637938
94LMTK20.43444388
95MAPK120.42956928
96MAP3K100.42270092
97PAK20.41440088
98MAP3K70.41347326
99LIMK10.39887707
100LATS20.39453701
101TRPM70.39066274
102YES10.38969237
103FGFR40.38823328
104PRKCG0.34974192
105CSNK1A1L0.34419689
106NEK90.34273558
107PKN10.33328870
108CAMK2A0.33132963
109PLK40.32824265
110NME20.32673818
111CDK70.32368832
112CSNK1D0.31613650
113IGF1R0.31062777
114SGK2230.31043970
115SGK4940.31043970
116MAP3K40.29773518
117DDR20.29223778
118CDK80.29215384
119BMPR1B0.29083827
120FGFR10.28852136
121TAOK20.28808797
122PIK3CA0.28662575
123MAP3K30.28377639
124TESK10.27858150
125TYK20.27850777
126ERBB30.27368521
127MST40.26284375
128PIM20.25500081
129EPHA20.23008754
130KIT0.22886133
131MATK0.22763204
132EGFR0.22605328
133MAP2K20.22589346
134NEK20.21695050
135PLK30.21519235
136SRC0.21477708
137MARK30.20929740
138LYN0.20784362
139EEF2K0.20534051
140STK30.18494858
141ZAK0.18170396
142VRK10.18118766
143MAPK70.17108459
144TBK10.16984384
145MAP4K10.16889505
146PAK30.16838451
147MAP3K10.16633079
148PRKD10.16255363
149OBSCN0.16140176
150DMPK0.15852753
151ILK0.15701196
152EPHA30.14835080
153BCKDK0.13782789
154CLK10.12824440
155BUB10.11732434
156EIF2AK10.10959286
157INSR0.10450260
158CDK60.10077435
159PDK30.09872995
160PDK40.09872995
161PLK10.09346495

Predicted pathways (KEGG)

RankGene SetZ-score
1Malaria_Homo sapiens_hsa051444.56802641
2Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005323.14779638
3African trypanosomiasis_Homo sapiens_hsa051433.00935579
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.73473846
5Primary bile acid biosynthesis_Homo sapiens_hsa001202.51917190
6Steroid hormone biosynthesis_Homo sapiens_hsa001402.43846430
7Focal adhesion_Homo sapiens_hsa045102.41118045
8Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.35560492
9AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049332.28901278
10Leukocyte transendothelial migration_Homo sapiens_hsa046702.21231749
11Nitrogen metabolism_Homo sapiens_hsa009102.14342529
12ECM-receptor interaction_Homo sapiens_hsa045122.13461073
13Butanoate metabolism_Homo sapiens_hsa006502.08065813
14Pantothenate and CoA biosynthesis_Homo sapiens_hsa007702.06891036
15Retinol metabolism_Homo sapiens_hsa008301.86473309
16DNA replication_Homo sapiens_hsa030301.86402634
17Chemical carcinogenesis_Homo sapiens_hsa052041.84804051
18* Complement and coagulation cascades_Homo sapiens_hsa046101.83483279
19Dilated cardiomyopathy_Homo sapiens_hsa054141.80130615
20Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.79742711
21Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.77192095
22Pentose and glucuronate interconversions_Homo sapiens_hsa000401.76294950
23Adherens junction_Homo sapiens_hsa045201.74349769
24Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.71713015
25Propanoate metabolism_Homo sapiens_hsa006401.71076406
26Fat digestion and absorption_Homo sapiens_hsa049751.69635617
27Tryptophan metabolism_Homo sapiens_hsa003801.69626648
28Antigen processing and presentation_Homo sapiens_hsa046121.68727914
29Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.68537614
30Rap1 signaling pathway_Homo sapiens_hsa040151.65519088
31PI3K-Akt signaling pathway_Homo sapiens_hsa041511.60863089
32Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.60828817
33Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.59335794
34Histidine metabolism_Homo sapiens_hsa003401.54082629
35Small cell lung cancer_Homo sapiens_hsa052221.51785938
36Starch and sucrose metabolism_Homo sapiens_hsa005001.50655986
37Selenocompound metabolism_Homo sapiens_hsa004501.49679978
38TNF signaling pathway_Homo sapiens_hsa046681.48175734
39Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.46719384
40Linoleic acid metabolism_Homo sapiens_hsa005911.45378094
41Fatty acid biosynthesis_Homo sapiens_hsa000611.43097830
42Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.42095786
43Proteoglycans in cancer_Homo sapiens_hsa052051.38847492
44Steroid biosynthesis_Homo sapiens_hsa001001.31838842
45alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.31744641
46Thyroid cancer_Homo sapiens_hsa052161.29869187
47Glycosaminoglycan degradation_Homo sapiens_hsa005311.29312341
48Mismatch repair_Homo sapiens_hsa034301.29196296
49Maturity onset diabetes of the young_Homo sapiens_hsa049501.23934714
50HTLV-I infection_Homo sapiens_hsa051661.21474025
51Fatty acid metabolism_Homo sapiens_hsa012121.21244113
52HIF-1 signaling pathway_Homo sapiens_hsa040661.20401121
53Cell cycle_Homo sapiens_hsa041101.16808462
54Caffeine metabolism_Homo sapiens_hsa002321.16364062
55Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.15205411
56TGF-beta signaling pathway_Homo sapiens_hsa043501.14550216
57Glycerolipid metabolism_Homo sapiens_hsa005611.13996245
58Platelet activation_Homo sapiens_hsa046111.12289296
59Sphingolipid metabolism_Homo sapiens_hsa006001.12273294
60Lysine degradation_Homo sapiens_hsa003101.11416257
61Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.10721953
62Phototransduction_Homo sapiens_hsa047441.10379003
63Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.08615728
64Viral carcinogenesis_Homo sapiens_hsa052031.07849733
65Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.06678781
66Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.05661679
67Jak-STAT signaling pathway_Homo sapiens_hsa046301.05655272
68Toxoplasmosis_Homo sapiens_hsa051451.05291775
69Viral myocarditis_Homo sapiens_hsa054161.04820551
70Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.03806567
71Vitamin digestion and absorption_Homo sapiens_hsa049771.02776176
72Dorso-ventral axis formation_Homo sapiens_hsa043201.02019830
73Galactose metabolism_Homo sapiens_hsa000521.01124512
74Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.00479465
75p53 signaling pathway_Homo sapiens_hsa041151.00199409
76Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.99532657
77Pathways in cancer_Homo sapiens_hsa052000.99167581
78Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.98098429
79Peroxisome_Homo sapiens_hsa041460.97142698
80Bile secretion_Homo sapiens_hsa049760.95865020
812-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.95179119
82Vascular smooth muscle contraction_Homo sapiens_hsa042700.94148275
83N-Glycan biosynthesis_Homo sapiens_hsa005100.93925657
84Amoebiasis_Homo sapiens_hsa051460.93352563
85Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.93198352
86Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.93104274
87Ether lipid metabolism_Homo sapiens_hsa005650.91139426
88Nucleotide excision repair_Homo sapiens_hsa034200.89993644
89Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.89605261
90Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.88984366
91Notch signaling pathway_Homo sapiens_hsa043300.88453698
92Ras signaling pathway_Homo sapiens_hsa040140.85528584
93Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.84859012
94Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.83858445
95Apoptosis_Homo sapiens_hsa042100.83025441
96Leishmaniasis_Homo sapiens_hsa051400.83013140
97Thyroid hormone synthesis_Homo sapiens_hsa049180.81596309
98Osteoclast differentiation_Homo sapiens_hsa043800.81396651
99Arginine biosynthesis_Homo sapiens_hsa002200.81141939
100Mineral absorption_Homo sapiens_hsa049780.81090392
101Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.80379274
102Legionellosis_Homo sapiens_hsa051340.78847141
103Shigellosis_Homo sapiens_hsa051310.77821833
104RNA transport_Homo sapiens_hsa030130.77589055
105Regulation of actin cytoskeleton_Homo sapiens_hsa048100.77309640
106Lysosome_Homo sapiens_hsa041420.76847168
107ABC transporters_Homo sapiens_hsa020100.76374370
108Hematopoietic cell lineage_Homo sapiens_hsa046400.75954139
109beta-Alanine metabolism_Homo sapiens_hsa004100.75545868
110Base excision repair_Homo sapiens_hsa034100.75427092
111PPAR signaling pathway_Homo sapiens_hsa033200.75230000
112Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.74280492
113VEGF signaling pathway_Homo sapiens_hsa043700.69872554
114One carbon pool by folate_Homo sapiens_hsa006700.69673101
115Tight junction_Homo sapiens_hsa045300.68707772
116Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.67022530
117Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.66869040
118Taste transduction_Homo sapiens_hsa047420.66472071
119Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.66357661
120Herpes simplex infection_Homo sapiens_hsa051680.66003021
121Protein digestion and absorption_Homo sapiens_hsa049740.64994252
122Hippo signaling pathway_Homo sapiens_hsa043900.64480372
123NF-kappa B signaling pathway_Homo sapiens_hsa040640.63982253
124MicroRNAs in cancer_Homo sapiens_hsa052060.63573898
125Basal transcription factors_Homo sapiens_hsa030220.62781249
126Ovarian steroidogenesis_Homo sapiens_hsa049130.61534223
127Other glycan degradation_Homo sapiens_hsa005110.61117285
128Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.60649869
129Ribosome_Homo sapiens_hsa030100.59485595
130Arachidonic acid metabolism_Homo sapiens_hsa005900.59271256
131Serotonergic synapse_Homo sapiens_hsa047260.58263455
132Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.56743969
133Central carbon metabolism in cancer_Homo sapiens_hsa052300.56637015
134Bladder cancer_Homo sapiens_hsa052190.56268338
135Carbon metabolism_Homo sapiens_hsa012000.55981428
136Drug metabolism - other enzymes_Homo sapiens_hsa009830.55346154
137Pancreatic cancer_Homo sapiens_hsa052120.55275994
138Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.53344304
139Calcium signaling pathway_Homo sapiens_hsa040200.52968448
140Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.52864789
141Olfactory transduction_Homo sapiens_hsa047400.52681351
142Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.51236706
143Hepatitis B_Homo sapiens_hsa051610.51224679
144Chronic myeloid leukemia_Homo sapiens_hsa052200.51099125
145Salivary secretion_Homo sapiens_hsa049700.51064270
146Glutamatergic synapse_Homo sapiens_hsa047240.50098386
147Measles_Homo sapiens_hsa051620.49560565
148Melanoma_Homo sapiens_hsa052180.49234712
149Pertussis_Homo sapiens_hsa051330.49232465
150Staphylococcus aureus infection_Homo sapiens_hsa051500.48380833
151Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.48026588
152Renin-angiotensin system_Homo sapiens_hsa046140.47460982
153Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.47255957
154Epstein-Barr virus infection_Homo sapiens_hsa051690.47189663
155Sulfur metabolism_Homo sapiens_hsa009200.46261616
156Pyrimidine metabolism_Homo sapiens_hsa002400.46082309
157Fatty acid degradation_Homo sapiens_hsa000710.45847665
158Circadian rhythm_Homo sapiens_hsa047100.44850265
159Tyrosine metabolism_Homo sapiens_hsa003500.44543214
160Spliceosome_Homo sapiens_hsa030400.43983097
161Cysteine and methionine metabolism_Homo sapiens_hsa002700.43870697
162Insulin resistance_Homo sapiens_hsa049310.43837441
163Arginine and proline metabolism_Homo sapiens_hsa003300.43691296
164Morphine addiction_Homo sapiens_hsa050320.42568712
165Homologous recombination_Homo sapiens_hsa034400.42222776
166Cyanoamino acid metabolism_Homo sapiens_hsa004600.41998708
167RNA degradation_Homo sapiens_hsa030180.41647664
168Proteasome_Homo sapiens_hsa030500.40604852
169Phagosome_Homo sapiens_hsa041450.39238030
170Pancreatic secretion_Homo sapiens_hsa049720.33888191
171Nicotine addiction_Homo sapiens_hsa050330.33381011

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