TFIP11

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein component of the spliceosome that promotes the release of the lariat-intron during late-stage splicing through the recruitment of a pre-mRNA splicing factor called DEAH-box helicase 15. The encoded protein contains a G-patch domain, a hallmark of RNA-processing proteins, that binds DEAH-box helicase 15. This protein contains an atypical nuclear localization sequence as well as a nuclear speckle-targeting sequence, enabling it to localize to distinct speckled regions within the cell nucleus. Polymorphisms in this gene are associated with dental caries suggesting a role in amelogenesis. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA unwinding involved in DNA replication (GO:0006268)4.43022694
2negative regulation of retinoic acid receptor signaling pathway (GO:0048387)4.42843418
3regulation of translational termination (GO:0006449)4.39952677
4folic acid-containing compound biosynthetic process (GO:0009396)4.26857104
5NIK/NF-kappaB signaling (GO:0038061)4.21946531
6modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.12247655
7positive regulation by organism of defense response of other organism involved in symbiotic interact4.12247655
8modulation by symbiont of host immune response (GO:0052553)4.12247655
9positive regulation by symbiont of host defense response (GO:0052509)4.12247655
10modulation by symbiont of host defense response (GO:0052031)4.12247655
11modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.12247655
12mitotic nuclear envelope disassembly (GO:0007077)4.02870030
13protein localization to kinetochore (GO:0034501)3.95995667
14heterochromatin organization (GO:0070828)3.94025379
15antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.83584663
16regulation of retinoic acid receptor signaling pathway (GO:0048385)3.81662274
17membrane disassembly (GO:0030397)3.80736245
18nuclear envelope disassembly (GO:0051081)3.80736245
19maturation of SSU-rRNA (GO:0030490)3.77168622
20pre-miRNA processing (GO:0031054)3.72859425
21positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.72528819
22positive thymic T cell selection (GO:0045059)3.68236019
23regulation of B cell receptor signaling pathway (GO:0050855)3.68016741
24peptidyl-arginine omega-N-methylation (GO:0035247)3.64152932
25regulation of gamma-delta T cell differentiation (GO:0045586)3.62410734
26negative regulation of cAMP-mediated signaling (GO:0043951)3.56969592
27nucleobase biosynthetic process (GO:0046112)3.55561725
28negative regulation of interleukin-12 production (GO:0032695)3.51788938
29formation of translation preinitiation complex (GO:0001731)3.48308306
30positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.41447555
31regulation of translational fidelity (GO:0006450)3.37734399
32negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)3.32728515
33ncRNA 3-end processing (GO:0043628)3.32667306
34peptidyl-arginine methylation (GO:0018216)3.32660211
35peptidyl-arginine N-methylation (GO:0035246)3.32660211
36maternal placenta development (GO:0001893)3.30720462
37response to peptidoglycan (GO:0032494)3.30587988
38folic acid metabolic process (GO:0046655)3.28128610
39DNA replication checkpoint (GO:0000076)3.25983563
40nuclear pore complex assembly (GO:0051292)3.25651670
41nuclear envelope organization (GO:0006998)3.23772124
42macrophage activation involved in immune response (GO:0002281)3.22327767
43T cell migration (GO:0072678)3.21439823
44positive regulation of protein homooligomerization (GO:0032464)3.21242526
45DNA strand elongation involved in DNA replication (GO:0006271)3.21158283
46negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.16134822
473-UTR-mediated mRNA stabilization (GO:0070935)3.15529177
48nuclear pore organization (GO:0006999)3.12555252
49protein localization to chromosome, centromeric region (GO:0071459)3.11821903
50intracellular estrogen receptor signaling pathway (GO:0030520)3.10960716
51DNA replication initiation (GO:0006270)3.10015864
52mitotic G1/S transition checkpoint (GO:0044819)3.09743382
53viral transcription (GO:0019083)3.09200083
54response to muramyl dipeptide (GO:0032495)3.07203900
55regulation of gamma-delta T cell activation (GO:0046643)3.06683445
56regulation of protein heterodimerization activity (GO:0043497)3.05385475
57type I interferon signaling pathway (GO:0060337)3.03289203
58cellular response to type I interferon (GO:0071357)3.03289203
59spliceosomal tri-snRNP complex assembly (GO:0000244)3.03002329
60regulation of interferon-beta biosynthetic process (GO:0045357)3.02883149
61negative thymic T cell selection (GO:0045060)3.02877800
62translational initiation (GO:0006413)3.01174843
63negative regulation of T cell mediated immunity (GO:0002710)3.01079773
64glucocorticoid receptor signaling pathway (GO:0042921)3.01047848
65ribosome biogenesis (GO:0042254)3.00122832
66DNA strand elongation (GO:0022616)3.00052732
67translational termination (GO:0006415)2.99856304
68cellular response to interleukin-15 (GO:0071350)2.99513185
69thymic T cell selection (GO:0045061)2.99395413
70translational elongation (GO:0006414)2.98360209
71positive regulation of gamma-delta T cell activation (GO:0046645)2.98174748
72mitotic G1 DNA damage checkpoint (GO:0031571)2.97869907
73immunoglobulin mediated immune response (GO:0016064)2.96735761
74mRNA stabilization (GO:0048255)2.95104375
75RNA stabilization (GO:0043489)2.95104375
76response to type I interferon (GO:0034340)2.95040835
77negative T cell selection (GO:0043383)2.94379592
78regulation of T cell tolerance induction (GO:0002664)2.94126478
79regulation of chromatin binding (GO:0035561)2.92033235
80DNA replication-dependent nucleosome assembly (GO:0006335)2.91208385
81DNA replication-dependent nucleosome organization (GO:0034723)2.91208385
82germinal center formation (GO:0002467)2.90295859
83positive regulation of B cell differentiation (GO:0045579)2.89257137
84detection of molecule of bacterial origin (GO:0032490)2.87774722
85leukocyte aggregation (GO:0070486)2.87352366
86regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.87167493
87response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.87110863
88response to host immune response (GO:0052572)2.87110863
89antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.87003259
90antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.87003259
91endothelial cell chemotaxis (GO:0035767)2.86719235
92purine nucleobase biosynthetic process (GO:0009113)2.85738972
93T cell apoptotic process (GO:0070231)2.85614345
94IMP biosynthetic process (GO:0006188)2.84912433
95lipopolysaccharide-mediated signaling pathway (GO:0031663)2.84598812
96nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.83212820
97detection of other organism (GO:0098543)2.80915867
98histone arginine methylation (GO:0034969)2.80859191
99regulation of NFAT protein import into nucleus (GO:0051532)2.80758642
100DNA duplex unwinding (GO:0032508)2.76386390
101regulation of interferon-gamma-mediated signaling pathway (GO:0060334)2.76242091
102response to interleukin-15 (GO:0070672)2.73637222
103regulation of type I interferon-mediated signaling pathway (GO:0060338)2.73548167
104DNA geometric change (GO:0032392)2.72258035
105dosage compensation (GO:0007549)2.72233815
106peptidyl-lysine dimethylation (GO:0018027)2.70169401
107negative regulation of lymphocyte mediated immunity (GO:0002707)2.69714093
108negative regulation of cell killing (GO:0031342)2.69610960
109negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.69610960
110alternative mRNA splicing, via spliceosome (GO:0000380)2.68438098
111negative regulation of histone methylation (GO:0031061)2.68350922
112histone H2A monoubiquitination (GO:0035518)2.67731239
113tolerance induction (GO:0002507)2.67562869
114myeloid dendritic cell differentiation (GO:0043011)2.67460667
115positive T cell selection (GO:0043368)2.67376857
116regulation of response to interferon-gamma (GO:0060330)2.66236337
117positive regulation of nuclease activity (GO:0032075)2.65831843
118mitotic chromosome condensation (GO:0007076)2.65755402
119regulation of RNA export from nucleus (GO:0046831)2.65613888
120mitotic sister chromatid segregation (GO:0000070)2.65410105
121positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.64422332
122cellular response to interleukin-4 (GO:0071353)2.63873508
123negative regulation of RNA splicing (GO:0033119)2.63521313
124* RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.62978173
125* mRNA splicing, via spliceosome (GO:0000398)2.62978173
126detection of bacterium (GO:0016045)2.62777283
127activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.62424354
128Arp2/3 complex-mediated actin nucleation (GO:0034314)2.62092828
129B cell receptor signaling pathway (GO:0050853)2.61947086
130detection of external biotic stimulus (GO:0098581)2.61833687
131tetrahydrofolate metabolic process (GO:0046653)2.61010507
132IMP metabolic process (GO:0046040)2.60180283
133* RNA splicing, via transesterification reactions (GO:0000375)2.60062050
134amino sugar catabolic process (GO:0046348)2.58988835
135epithelial cell differentiation involved in prostate gland development (GO:0060742)2.58988706
136regulation of defense response to virus by host (GO:0050691)2.58023096
137negative regulation of translational initiation (GO:0045947)2.57997294
138regulation of B cell differentiation (GO:0045577)2.57946727
139trophectodermal cell differentiation (GO:0001829)2.57940674
140regulation of tolerance induction (GO:0002643)2.57138593
141glycine metabolic process (GO:0006544)2.56671442
142natural killer cell differentiation (GO:0001779)2.56670271
143regulation of translational initiation (GO:0006446)2.56398996
144negative regulation of leukocyte mediated immunity (GO:0002704)2.55864296
145neutrophil activation involved in immune response (GO:0002283)2.55691050
146ribonucleoprotein complex biogenesis (GO:0022613)2.55596648
147histone-serine phosphorylation (GO:0035404)2.55265170
148antigen processing and presentation of endogenous antigen (GO:0019883)2.55231448
149apoptotic process involved in morphogenesis (GO:0060561)2.54092975
150myeloid cell activation involved in immune response (GO:0002275)2.54022750
151protein complex disassembly (GO:0043241)2.53303767
152cellular protein complex disassembly (GO:0043624)2.53168556
153negative regulation of innate immune response (GO:0045824)2.52544457
154COPI coating of Golgi vesicle (GO:0048205)2.52465432
155cellular extravasation (GO:0045123)2.52206407
156myeloid dendritic cell activation (GO:0001773)2.52144492
157B cell homeostasis (GO:0001782)2.51486169
158response to protozoan (GO:0001562)2.51009824
159T cell selection (GO:0045058)2.50640507
160positive regulation of isotype switching (GO:0045830)2.49911068
161N-acetylneuraminate metabolic process (GO:0006054)2.49867222
162response to host (GO:0075136)2.48709883
163response to host defenses (GO:0052200)2.48709883
164response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.48709883
165negative regulation of interleukin-6 production (GO:0032715)2.48276067
166regulation of alpha-beta T cell proliferation (GO:0046640)2.45414249
167B cell mediated immunity (GO:0019724)2.44981917
168defense response to protozoan (GO:0042832)2.44723944
169positive regulation of interleukin-2 production (GO:0032743)2.44315363
170regulation of necroptotic process (GO:0060544)2.44011921
171chaperone mediated protein folding requiring cofactor (GO:0051085)2.43491774
172macrophage activation (GO:0042116)2.41785834
173regulation of T-helper 2 cell differentiation (GO:0045628)2.41688471
174neutrophil mediated immunity (GO:0002446)2.40912096
175regulation of interleukin-2 biosynthetic process (GO:0045076)2.39330345
176regulation of T cell mediated cytotoxicity (GO:0001914)2.37681702
177programmed necrotic cell death (GO:0097300)2.37171546
178granulocyte activation (GO:0036230)2.36303228
179regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)2.34023038
180positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.33569882
181production of molecular mediator involved in inflammatory response (GO:0002532)2.33275847
182regulation of isotype switching (GO:0045191)2.32502194
183negative regulation of cytokine production involved in immune response (GO:0002719)2.31604163
184T-helper 1 type immune response (GO:0042088)2.29893693
185positive regulation of T cell mediated cytotoxicity (GO:0001916)2.29688031
186T cell homeostasis (GO:0043029)2.29623497
187positive regulation of tolerance induction (GO:0002645)2.29494094

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.75818800
2MYC_22102868_ChIP-Seq_BL_Human3.57495343
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.57224554
4IRF8_22096565_ChIP-ChIP_GC-B_Human3.36651466
5FOXM1_23109430_ChIP-Seq_U2OS_Human3.22330108
6EGR1_19374776_ChIP-ChIP_THP-1_Human3.11113129
7ELF1_17652178_ChIP-ChIP_JURKAT_Human2.81975336
8MYC_18555785_ChIP-Seq_MESCs_Mouse2.78121429
9BP1_19119308_ChIP-ChIP_Hs578T_Human2.74654447
10NOTCH1_21737748_ChIP-Seq_TLL_Human2.62530876
11NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.57737132
12IRF8_21731497_ChIP-ChIP_J774_Mouse2.50150881
13VDR_21846776_ChIP-Seq_THP-1_Human2.39520872
14IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.31897835
15MYC_19079543_ChIP-ChIP_MESCs_Mouse2.30753510
16SPI1_23547873_ChIP-Seq_NB4_Human2.20869468
17SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.08967955
18STAT4_19710469_ChIP-ChIP_TH1__Mouse2.07849858
19KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.99236795
20XRN2_22483619_ChIP-Seq_HELA_Human1.98212058
21FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.97221440
22SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.88347180
23TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.85001543
24FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.83140387
25TCF7_22412390_ChIP-Seq_EML_Mouse1.83023174
26CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.79074745
27E2F4_17652178_ChIP-ChIP_JURKAT_Human1.78982128
28MYC_18358816_ChIP-ChIP_MESCs_Mouse1.77776973
29* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.77015326
30IRF8_27001747_Chip-Seq_BMDM_Mouse1.75581957
31KDM2B_26808549_Chip-Seq_DND41_Human1.74987059
32CIITA_25753668_ChIP-Seq_RAJI_Human1.74419453
33KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.72785214
34ELK3_25401928_ChIP-Seq_HUVEC_Human1.72142307
35* ETS1_20019798_ChIP-Seq_JURKAT_Human1.71883211
36CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.71821085
37MYC_19030024_ChIP-ChIP_MESCs_Mouse1.70939932
38CREB1_15753290_ChIP-ChIP_HEK293T_Human1.70439260
39KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.64608202
40MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.60834947
41MAF_26560356_Chip-Seq_TH1_Human1.59000017
42CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.58757051
43UTX_26944678_Chip-Seq_JUKART_Human1.58632206
44ZNF263_19887448_ChIP-Seq_K562_Human1.57813746
45LXR_22292898_ChIP-Seq_THP-1_Human1.56089779
46KDM2B_26808549_Chip-Seq_SUP-B15_Human1.55890218
47* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.54061688
48CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.51874773
49DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.51586894
50IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.50980346
51NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.50092490
52MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.48406353
53STAT3_1855785_ChIP-Seq_MESCs_Mouse1.47703676
54CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.46460087
55SCL_19346495_ChIP-Seq_HPC-7_Human1.45340174
56NELFA_20434984_ChIP-Seq_ESCs_Mouse1.44688510
57ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.44674965
58TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.43297709
59POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.42772555
60SPI1_23127762_ChIP-Seq_K562_Human1.42689133
61ERG_20887958_ChIP-Seq_HPC-7_Mouse1.42478511
62RUNX_20019798_ChIP-Seq_JUKART_Human1.41931331
63* GABP_19822575_ChIP-Seq_HepG2_Human1.37405802
64* JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.37085383
65ATF3_27146783_Chip-Seq_COLON_Human1.36807864
66* EST1_17652178_ChIP-ChIP_JURKAT_Human1.36509619
67KLF4_18555785_ChIP-Seq_MESCs_Mouse1.34226921
68HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.34169015
69* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.33788551
70STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.33385592
71MAF_26560356_Chip-Seq_TH2_Human1.29349514
72* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.28084526
73E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.27931160
74KDM5A_27292631_Chip-Seq_BREAST_Human1.27908869
75FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.26720506
76TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.25013713
77RACK7_27058665_Chip-Seq_MCF-7_Human1.24775913
78MYCN_18555785_ChIP-Seq_MESCs_Mouse1.24561058
79DCP1A_22483619_ChIP-Seq_HELA_Human1.23881176
80GATA3_27048872_Chip-Seq_THYMUS_Human1.23005556
81VDR_24763502_ChIP-Seq_THP-1_Human1.22931714
82E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.22547932
83ZFX_18555785_ChIP-Seq_MESCs_Mouse1.21898542
84TFEB_21752829_ChIP-Seq_HELA_Human1.21830280
85* GATA2_22383799_ChIP-Seq_G1ME_Mouse1.21380094
86PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.21309575
87AR_21909140_ChIP-Seq_LNCAP_Human1.21191905
88ZFP281_18757296_ChIP-ChIP_E14_Mouse1.21179155
89E2F1_21310950_ChIP-Seq_MCF-7_Human1.20886093
90PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.20705323
91VDR_23849224_ChIP-Seq_CD4+_Human1.20083539
92CLOCK_20551151_ChIP-Seq_293T_Human1.19348665
93FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.18702555
94TTF2_22483619_ChIP-Seq_HELA_Human1.18344401
95* GABP_17652178_ChIP-ChIP_JURKAT_Human1.18040072
96STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.17687806
97GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.17670764
98FOXP3_21729870_ChIP-Seq_TREG_Human1.17065863
99KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.15673381
100* THAP11_20581084_ChIP-Seq_MESCs_Mouse1.15571454
101P68_20966046_ChIP-Seq_HELA_Human1.14887607
102NANOG_18555785_ChIP-Seq_MESCs_Mouse1.14775078
103NCOR1_26117541_ChIP-Seq_K562_Human1.14527888
104* GATA3_26560356_Chip-Seq_TH2_Human1.13593289
105* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.13213452
106YY1_21170310_ChIP-Seq_MESCs_Mouse1.13174232
107PU.1_20513432_ChIP-Seq_Bcells_Mouse1.12764522
108MYB_26560356_Chip-Seq_TH1_Human1.12680775
109ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.12597755
110VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.11521039
111ELF1_20517297_ChIP-Seq_JURKAT_Human1.11253505
112MYB_26560356_Chip-Seq_TH2_Human1.10981074
113* RUNX1_22412390_ChIP-Seq_EML_Mouse1.10451426
114STAT6_21828071_ChIP-Seq_BEAS2B_Human1.09999748
115* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.08867534
116CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.08310307
117BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.07419778
118SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.07352652
119NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.06945387
120POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.06739732
121* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.06625842
122SRY_22984422_ChIP-ChIP_TESTIS_Rat1.05241689
123E2F1_18555785_ChIP-Seq_MESCs_Mouse1.03790097
124SRF_21415370_ChIP-Seq_HL-1_Mouse1.03120567
125BCOR_27268052_Chip-Seq_Bcells_Human1.02963785
126GATA1_19941827_ChIP-Seq_MEL_Mouse1.02755287
127KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.02698302
128MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.01628602
129BCL6_27268052_Chip-Seq_Bcells_Human1.00664518
130* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.99975326
131TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.99456774
132* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.99234942
133KDM2B_26808549_Chip-Seq_JURKAT_Human0.97645105
134STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.97247749
135* SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.95199188
136RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.94888215
137EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.94332088
138* FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.94079860
139RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.93608067
140MYB_21317192_ChIP-Seq_ERMYB_Mouse0.93013772
141E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.92448805
142HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.91888610

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching3.09173610
2MP0003111_abnormal_nucleus_morphology2.97183425
3MP0003705_abnormal_hypodermis_morpholog2.91412492
4MP0010352_gastrointestinal_tract_polyps2.82574326
5MP0003303_peritoneal_inflammation2.82530030
6MP0009840_abnormal_foam_cell2.72664473
7MP0005451_abnormal_body_composition2.67502066
8MP0005076_abnormal_cell_differentiation2.67063734
9MP0003077_abnormal_cell_cycle2.50799424
10MP0004957_abnormal_blastocyst_morpholog2.43668379
11MP0003724_increased_susceptibility_to2.40457805
12MP0010094_abnormal_chromosome_stability2.33353587
13MP0000015_abnormal_ear_pigmentation2.29214309
14MP0008260_abnormal_autophagy2.26266609
15MP0002148_abnormal_hypersensitivity_rea2.23639724
16MP0009785_altered_susceptibility_to2.17395541
17MP0001730_embryonic_growth_arrest2.16516899
18MP0002419_abnormal_innate_immunity2.16101421
19MP0002653_abnormal_ependyma_morphology2.14212613
20MP0005025_abnormal_response_to2.06527515
21MP0003300_gastrointestinal_ulcer2.03568645
22MP0003763_abnormal_thymus_physiology2.01711375
23MP0005075_abnormal_melanosome_morpholog1.99210879
24MP0008961_abnormal_basal_metabolism1.99024359
25MP0000685_abnormal_immune_system1.92432262
26MP0004381_abnormal_hair_follicle1.90862354
27MP0009333_abnormal_splenocyte_physiolog1.89738032
28MP0000350_abnormal_cell_proliferation1.88531611
29MP0002132_abnormal_respiratory_system1.85105028
30MP0008057_abnormal_DNA_replication1.83250723
31MP0010307_abnormal_tumor_latency1.81937988
32MP0003123_paternal_imprinting1.81592126
33MP0000703_abnormal_thymus_morphology1.78733845
34MP0004510_myositis1.75285987
35MP0008007_abnormal_cellular_replicative1.70403920
36MP0002877_abnormal_melanocyte_morpholog1.70194446
37MP0003566_abnormal_cell_adhesion1.67773012
38MP0001853_heart_inflammation1.67464677
39MP0002396_abnormal_hematopoietic_system1.67415556
40MP0003984_embryonic_growth_retardation1.64474633
41MP0002088_abnormal_embryonic_growth/wei1.63922490
42MP0009278_abnormal_bone_marrow1.63437487
43MP0009764_decreased_sensitivity_to1.62965723
44MP0001672_abnormal_embryogenesis/_devel1.60528484
45MP0005380_embryogenesis_phenotype1.60528484
46MP0003656_abnormal_erythrocyte_physiolo1.58971197
47MP0002398_abnormal_bone_marrow1.58822913
48MP0001849_ear_inflammation1.56579482
49MP0001697_abnormal_embryo_size1.55779875
50MP0004808_abnormal_hematopoietic_stem1.55096154
51MP0004947_skin_inflammation1.53015435
52MP0008932_abnormal_embryonic_tissue1.51251132
53MP0005310_abnormal_salivary_gland1.49832364
54MP0005023_abnormal_wound_healing1.48564738
55MP0002722_abnormal_immune_system1.48427694
56MP0002080_prenatal_lethality1.48418952
57MP0003806_abnormal_nucleotide_metabolis1.46713620
58MP0006035_abnormal_mitochondrial_morpho1.46216430
59MP0003221_abnormal_cardiomyocyte_apopto1.46038403
60MP0003828_pulmonary_edema1.45263348
61MP0000569_abnormal_digit_pigmentation1.44324045
62MP0001800_abnormal_humoral_immune1.40215921
63MP0000689_abnormal_spleen_morphology1.38772582
64MP0003646_muscle_fatigue1.37562573
65MP0000372_irregular_coat_pigmentation1.37481608
66MP0000490_abnormal_crypts_of1.35431058
67MP0000465_gastrointestinal_hemorrhage1.33127593
68MP0003436_decreased_susceptibility_to1.33089457
69MP0001545_abnormal_hematopoietic_system1.32575496
70MP0005397_hematopoietic_system_phenotyp1.32575496
71MP0000858_altered_metastatic_potential1.30200602
72MP0002086_abnormal_extraembryonic_tissu1.29261323
73MP0002405_respiratory_system_inflammati1.28685434
74MP0004197_abnormal_fetal_growth/weight/1.26615145
75MP0001533_abnormal_skeleton_physiology1.25833156
76MP0002019_abnormal_tumor_incidence1.24339443
77MP0000716_abnormal_immune_system1.24096068
78MP0002277_abnormal_respiratory_mucosa1.22205225
79MP0002429_abnormal_blood_cell1.21571207
80MP0005671_abnormal_response_to1.20856792
81MP0002723_abnormal_immune_serum1.19197202
82MP0002084_abnormal_developmental_patter1.19018184
83MP0002420_abnormal_adaptive_immunity1.18833223
84MP0002085_abnormal_embryonic_tissue1.18715638
85MP0002452_abnormal_antigen_presenting1.17845790
86MP0001819_abnormal_immune_cell1.17592651
87MP0001790_abnormal_immune_system1.16993749
88MP0005387_immune_system_phenotype1.16993749
89MP0008469_abnormal_protein_level1.16957760
90MP0005000_abnormal_immune_tolerance1.14085910
91MP0004233_abnormal_muscle_weight1.13540487
92MP0009672_abnormal_birth_weight1.13308796
93MP0000313_abnormal_cell_death1.12386943
94MP0005083_abnormal_biliary_tract1.10952229
95MP0000371_diluted_coat_color1.04756542
96MP0005621_abnormal_cell_physiology1.03908357
97MP0003191_abnormal_cellular_cholesterol1.02045619
98MP0002095_abnormal_skin_pigmentation1.01095506
99MP0000358_abnormal_cell_content/1.00896519
100MP0003866_abnormal_defecation1.00703981
101MP0006082_CNS_inflammation0.99983967
102MP0002089_abnormal_postnatal_growth/wei0.99631931
103MP0002332_abnormal_exercise_endurance0.98350437
104MP0001348_abnormal_lacrimal_gland0.97910953
105MP0006036_abnormal_mitochondrial_physio0.97420175
106MP0000733_abnormal_muscle_development0.95208457
107MP0003091_abnormal_cell_migration0.95072977
108MP0008058_abnormal_DNA_repair0.93991406
109MP0005408_hypopigmentation0.93965406
110MP0001915_intracranial_hemorrhage0.92017029
111MP0003172_abnormal_lysosome_physiology0.90141413
112MP0003448_altered_tumor_morphology0.88887473
113MP0000609_abnormal_liver_physiology0.88816353
114MP0001835_abnormal_antigen_presentation0.87886347
115MP0000537_abnormal_urethra_morphology0.87437608
116MP0005464_abnormal_platelet_physiology0.87416471
117MP0008770_decreased_survivor_rate0.87315465
118MP0003186_abnormal_redox_activity0.86528449
119MP0003786_premature_aging0.86505313
120MP0005384_cellular_phenotype0.86148293
121MP0001873_stomach_inflammation0.85190760
122MP0002166_altered_tumor_susceptibility0.83872833
123MP0009053_abnormal_anal_canal0.83670096
124MP0002138_abnormal_hepatobiliary_system0.83409524
125MP0006054_spinal_hemorrhage0.83383527
126MP0005058_abnormal_lysosome_morphology0.82762543
127MP0005623_abnormal_meninges_morphology0.80930740
128MP0009765_abnormal_xenobiotic_induced0.80042054
129MP0010155_abnormal_intestine_physiology0.78155552
130MP0001845_abnormal_inflammatory_respons0.78082053
131MP0000604_amyloidosis0.77833868
132MP0000598_abnormal_liver_morphology0.76439488
133MP0003183_abnormal_peptide_metabolism0.76149922
134MP0003136_yellow_coat_color0.75331059
135MP0000477_abnormal_intestine_morphology0.74017096
136MP0010630_abnormal_cardiac_muscle0.73308778
137MP0002254_reproductive_system_inflammat0.72245301
138MP0001986_abnormal_taste_sensitivity0.71488918
139MP0000343_altered_response_to0.69128980
140MP0003453_abnormal_keratinocyte_physiol0.67752160
141MP0009763_increased_sensitivity_to0.66569890
142MP0003950_abnormal_plasma_membrane0.64978638
143MP0002006_tumorigenesis0.61300868

Predicted human phenotypes

RankGene SetZ-score
1Recurrent bacterial skin infections (HP:0005406)4.58977863
2Recurrent abscess formation (HP:0002722)4.35894901
3Abnormality of glycolipid metabolism (HP:0010969)4.24276620
4Abnormality of liposaccharide metabolism (HP:0010968)4.24276620
5Abnormality of glycosphingolipid metabolism (HP:0004343)4.24276620
6Eczematoid dermatitis (HP:0000976)3.91093568
7Abnormality of macrophages (HP:0004311)3.78024784
8Increased density of long bones (HP:0006392)3.66329747
9Stomatitis (HP:0010280)3.61811342
10Orchitis (HP:0100796)3.43465869
11Gastrointestinal infarctions (HP:0005244)3.42358063
12Hand muscle atrophy (HP:0009130)3.40427436
13Albinism (HP:0001022)3.35004063
14Upper limb amyotrophy (HP:0009129)3.27465876
15Distal upper limb amyotrophy (HP:0007149)3.27465876
16Vacuolated lymphocytes (HP:0001922)3.26446396
17Mediastinal lymphadenopathy (HP:0100721)3.21651824
18Retrobulbar optic neuritis (HP:0100654)3.16901209
19Optic neuritis (HP:0100653)3.16901209
20Microvesicular hepatic steatosis (HP:0001414)3.14731865
21Cerebral aneurysm (HP:0004944)3.03512811
22Abnormality of the lower motor neuron (HP:0002366)2.93168346
23Ragged-red muscle fibers (HP:0003200)2.90533625
24Autoimmune hemolytic anemia (HP:0001890)2.88749753
25Selective tooth agenesis (HP:0001592)2.84684263
26Increased cerebral lipofuscin (HP:0011813)2.83172959
27Petechiae (HP:0000967)2.81749816
28Hyperacusis (HP:0010780)2.81377295
29Recurrent fungal infections (HP:0002841)2.80513932
30Nasal polyposis (HP:0100582)2.77361544
31Increased IgM level (HP:0003496)2.76134121
32Obstructive lung disease (HP:0006536)2.66934553
33Chronic obstructive pulmonary disease (HP:0006510)2.66934553
34Increased serum ferritin (HP:0003281)2.64537562
35Recurrent skin infections (HP:0001581)2.62149736
36Encephalitis (HP:0002383)2.61618170
37Pustule (HP:0200039)2.60365365
38Loss of speech (HP:0002371)2.58859205
39Deep palmar crease (HP:0006191)2.58760164
40Protrusio acetabuli (HP:0003179)2.58627463
41Abnormality of the anterior horn cell (HP:0006802)2.57334647
42Degeneration of anterior horn cells (HP:0002398)2.57334647
43Vasculitis (HP:0002633)2.56666867
44Achilles tendon contracture (HP:0001771)2.53576096
45Recurrent gram-negative bacterial infections (HP:0005420)2.53482728
46Genu recurvatum (HP:0002816)2.53396744
47Increased neuronal autofluorescent lipopigment (HP:0002074)2.47911098
48Meningitis (HP:0001287)2.45878346
49Abnormality of the nasal mucosa (HP:0000433)2.42811115
50Progressive external ophthalmoplegia (HP:0000590)2.42489872
51Abnormality of T cell physiology (HP:0011840)2.42176425
52Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.41546196
53Lymphopenia (HP:0001888)2.40083634
54Entropion (HP:0000621)2.39623397
55Ocular albinism (HP:0001107)2.38270123
56Difficulty climbing stairs (HP:0003551)2.36183207
57Elevated erythrocyte sedimentation rate (HP:0003565)2.34888710
58Abnormality of the Achilles tendon (HP:0005109)2.33674813
59Carpal bone hypoplasia (HP:0001498)2.33486141
60Granulocytopenia (HP:0001913)2.33476442
61Hypokinesia (HP:0002375)2.32852797
62Osteomyelitis (HP:0002754)2.29663387
63Severe short stature (HP:0003510)2.29013481
64Hypochromic anemia (HP:0001931)2.28674353
65Urticaria (HP:0001025)2.28577293
66Premature rupture of membranes (HP:0001788)2.28062645
67Keratoconjunctivitis sicca (HP:0001097)2.27404581
68Persistence of primary teeth (HP:0006335)2.26959025
69Abnormality of cells of the lymphoid lineage (HP:0012140)2.26524260
70Atrophy/Degeneration involving motor neurons (HP:0007373)2.26498929
71Dysostosis multiplex (HP:0000943)2.25926881
72Abnormality of the calcaneus (HP:0008364)2.22730802
73Inflammation of the large intestine (HP:0002037)2.22719498
74Chest pain (HP:0100749)2.19632393
75Autoimmune thrombocytopenia (HP:0001973)2.19336732
76Abnormal neuron morphology (HP:0012757)2.18977972
77Abnormality of the motor neurons (HP:0002450)2.18977972
78Recurrent cutaneous fungal infections (HP:0011370)2.18663328
79Chronic mucocutaneous candidiasis (HP:0002728)2.18663328
80Progressive neurologic deterioration (HP:0002344)2.18247036
81Global brain atrophy (HP:0002283)2.16272005
82Shallow orbits (HP:0000586)2.15094052
83Abnormality of iron homeostasis (HP:0011031)2.14752437
84Keratoconjunctivitis (HP:0001096)2.12719719
85Thrombocytosis (HP:0001894)2.11968835
86Short 4th metacarpal (HP:0010044)2.10194346
87Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.10194346
88Increased IgE level (HP:0003212)2.09744974
89Cone-rod dystrophy (HP:0000548)2.09299001
90Acute hepatic failure (HP:0006554)2.08969416
91Cerebral hypomyelination (HP:0006808)2.07739583
92Metaphyseal cupping (HP:0003021)2.07312729
93Pulmonary infiltrates (HP:0002113)2.07083006
94Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.06157631
95Anhidrosis (HP:0000970)2.05761180
96Ulnar bowing (HP:0003031)2.04903650
97Limb-girdle muscle atrophy (HP:0003797)2.04725084
98Basal cell carcinoma (HP:0002671)2.04345782
99Personality changes (HP:0000751)2.02231482
100Leukocytosis (HP:0001974)2.02195092
101Gingivitis (HP:0000230)2.01866097
102Eosinophilia (HP:0001880)2.01190402
103Cervical subluxation (HP:0003308)2.01108113
104Abnormality of the distal phalanges of the toes (HP:0010182)2.00310494
105Colitis (HP:0002583)2.00237534
106Keratitis (HP:0000491)2.00134853
107Anorexia (HP:0002039)1.99448219
108Insomnia (HP:0100785)1.99408244
109Ependymoma (HP:0002888)1.98847287
110Fatigue (HP:0012378)1.98652225
111IgA deficiency (HP:0002720)1.98421688
112IgG deficiency (HP:0004315)1.98296243
113Rectal prolapse (HP:0002035)1.98084556
114Progressive muscle weakness (HP:0003323)1.98032875
115Abnormality of the fingertips (HP:0001211)1.95810633
116Multiple enchondromatosis (HP:0005701)1.94861616
117Pointed chin (HP:0000307)1.94419217
118Spastic diplegia (HP:0001264)1.93221753
119Slow saccadic eye movements (HP:0000514)1.90898122
120Bicuspid aortic valve (HP:0001647)1.90170630
121Reticulocytosis (HP:0001923)1.89168990
122Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.88742264
123Pelvic girdle muscle weakness (HP:0003749)1.88372669
124Myositis (HP:0100614)1.87430429
125Amyotrophic lateral sclerosis (HP:0007354)1.87424530
126Abnormality of cells of the erythroid lineage (HP:0012130)1.87233189
127Trismus (HP:0000211)1.86830045
128Gastrointestinal stroma tumor (HP:0100723)1.86171252
129Chronic diarrhea (HP:0002028)1.84777881
130Iris hypopigmentation (HP:0007730)1.84744337
131High pitched voice (HP:0001620)1.82748092
132Cutaneous photosensitivity (HP:0000992)1.82173666
133Poor head control (HP:0002421)1.81779884
134Abnormal number of erythroid precursors (HP:0012131)1.80982489
135Deviation of the thumb (HP:0009603)1.80450945
136Abnormality of reticulocytes (HP:0004312)1.79910577
137Hypochromic microcytic anemia (HP:0004840)1.79864962
138Panhypogammaglobulinemia (HP:0003139)1.79440474
139Recurrent viral infections (HP:0004429)1.79127852
140T lymphocytopenia (HP:0005403)1.78935495
141Ankle contracture (HP:0006466)1.78047450
142Verrucae (HP:0200043)1.78040493
143Papilloma (HP:0012740)1.78040493
144Angiofibromas (HP:0010615)1.77877803
145Adenoma sebaceum (HP:0009720)1.77877803
146Prolonged neonatal jaundice (HP:0006579)1.77831103
147Hypertensive crisis (HP:0100735)1.77568678
148Vertebral arch anomaly (HP:0008438)1.77099697
149Mitral valve prolapse (HP:0001634)1.76724946
150Long palpebral fissure (HP:0000637)1.74991829
151Peripheral hypomyelination (HP:0007182)1.74727536
152Abnormality of eosinophils (HP:0001879)1.74230054
153Abnormality of mucopolysaccharide metabolism (HP:0011020)1.73870287
154Abnormality of polysaccharide metabolism (HP:0011012)1.73870287
155Abnormality of glycosaminoglycan metabolism (HP:0004371)1.73870287
156Cellulitis (HP:0100658)1.73463556
157Aplasia/Hypoplasia of the patella (HP:0006498)1.73198727
158Dysmetric saccades (HP:0000641)1.72328111
159IgM deficiency (HP:0002850)1.71036539
160Microretrognathia (HP:0000308)1.70994906
161Broad palm (HP:0001169)1.69920525
162Glossoptosis (HP:0000162)1.69473187
163Abnormality of the 4th metacarpal (HP:0010012)1.68785615
164Striae distensae (HP:0001065)1.68406352
165Renal duplication (HP:0000075)1.67944046
166Abnormality of T cells (HP:0002843)1.67506695
167Increased connective tissue (HP:0009025)1.66686389
168Radial bowing (HP:0002986)1.66513439
169Abnormality of the peritoneum (HP:0002585)1.65751222
170Gastrointestinal inflammation (HP:0004386)1.65137149
171Proximal placement of thumb (HP:0009623)1.64661241
172Reticulocytopenia (HP:0001896)1.63451175
173Agnosia (HP:0010524)1.63437414
174Dilatation of the ascending aorta (HP:0005111)1.62654139
175Annular pancreas (HP:0001734)1.62483944
176Patellar aplasia (HP:0006443)1.61971071
177Abnormality of T cell number (HP:0011839)1.60230267
178Pallor (HP:0000980)1.60056926
179Prominent nose (HP:0000448)1.59433738
180Neoplasm of the pancreas (HP:0002894)1.59181081
181Shoulder girdle muscle weakness (HP:0003547)1.58325385
182Abnormal delayed hypersensitivity skin test (HP:0002963)1.57966448
183Increased nuchal translucency (HP:0010880)1.57108070
184Abnormal number of incisors (HP:0011064)1.56701734
185Missing ribs (HP:0000921)1.56637054
186Peritonitis (HP:0002586)1.55210456

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EEF2K3.98475424
2TRIB33.77544457
3MAP3K103.68075204
4IRAK33.19003922
5ERN12.87636401
6MAP3K142.85443598
7CDK122.61915759
8PRPF4B2.57897150
9PDK22.52287815
10MAP4K12.51877336
11TSSK62.47105948
12NEK22.37998295
13PKN22.24593135
14STK102.10228802
15IRAK42.04641076
16BUB12.02751176
17IKBKE1.95761050
18CDC71.95524384
19TLK11.87160485
20BLK1.70139341
21SCYL21.66782722
22SIK31.65687007
23TESK21.65606974
24CSK1.65514109
25TAOK11.60274296
26GRK61.55887183
27MAP2K31.52517139
28ALK1.49658162
29EIF2AK11.47808633
30SRPK11.47418912
31LRRK21.45261418
32CDK41.45147867
33RIPK41.44540037
34FES1.42606004
35TTN1.40813895
36PASK1.37387542
37NEK11.33746457
38WEE11.31430364
39MAP3K81.28387296
40PIK3CG1.27775805
41MAP3K131.24343712
42FGR1.23484919
43ICK1.21451743
44FGFR41.19618733
45PTK61.19599006
46JAK31.15160855
47ZAP701.12635667
48TBK11.11804797
49MAP3K111.11662672
50RPS6KA41.11150371
51MAP3K11.10430419
52BRD41.09026739
53NME21.08909048
54MAP3K31.05315973
55PAK41.03123833
56PIM11.00781127
57SMG10.97967238
58PINK10.97505822
59ITK0.96890395
60LATS20.94210978
61TNK20.93505157
62RPS6KB20.93008029
63TESK10.92807181
64MTOR0.92001898
65EPHA20.91649586
66TAOK30.91393802
67IRAK10.90726259
68CDK70.89164100
69LYN0.88515173
70TTK0.86672928
71CCNB10.85104769
72SIK20.84145783
73BMX0.83904471
74CLK10.83398436
75PDGFRA0.80941231
76BCKDK0.79945511
77TYRO30.75606159
78PRKD20.75594887
79TYK20.72555520
80RAF10.72067978
81MAPKAPK30.70822791
82TEC0.70609354
83MATK0.69846325
84AURKA0.68869559
85PLK10.68520547
86CHEK10.67868767
87CHUK0.66736191
88PRKCQ0.66403813
89EPHB10.65779284
90ARAF0.64529336
91RIPK10.64144408
92DAPK30.61073799
93FGFR10.60672610
94PAK20.59209778
95STK40.58447371
96IRAK20.57287556
97BTK0.56002592
98CDK20.55511531
99KDR0.55326532
100PAK10.55235819
101CDK60.54679416
102TAOK20.54429786
103AURKB0.54128186
104MAP3K50.53314048
105BRSK10.52585014
106DYRK1B0.52251905
107HCK0.52212167
108ZAK0.52155511
109ATR0.51586013
110JAK10.50844396
111KSR20.48633203
112RPS6KC10.47712419
113RPS6KL10.47712419
114MAPK110.47086359
115MAPKAPK20.46884440
116CAMK1D0.46656383
117ILK0.46647818
118IKBKB0.46165007
119LCK0.45416884
120MAP3K60.45168192
121RPS6KA10.44666408
122PRKD30.44518753
123PTK20.42498428
124MAP2K20.42212040
125TGFBR10.42037945
126PRKCI0.41599946
127MELK0.41005606
128SYK0.40086468
129PRKCH0.39290027
130EIF2AK30.38629585
131PDK10.37764652
132MARK20.37203289
133MARK30.36680197
134JAK20.35581432
135TGFBR20.35090545
136NEK60.34232900
137ADRBK20.33718634
138PIM20.33607588
139CDK11A0.33015871
140STK110.32837570
141RPS6KA20.31481278
142ABL20.31446067
143CDK150.31280812
144TXK0.30352369
145NME10.30301089
146RET0.29213783
147CDK10.26586445

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.18655427
2One carbon pool by folate_Homo sapiens_hsa006702.77958922
3Spliceosome_Homo sapiens_hsa030402.67011806
4RNA transport_Homo sapiens_hsa030132.47867465
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.38462174
6Other glycan degradation_Homo sapiens_hsa005112.34726831
7Toll-like receptor signaling pathway_Homo sapiens_hsa046202.29857304
8Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.13817318
9Allograft rejection_Homo sapiens_hsa053302.05846325
10Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.01527488
11Antigen processing and presentation_Homo sapiens_hsa046122.00777142
12Graft-versus-host disease_Homo sapiens_hsa053321.95681881
13Cell cycle_Homo sapiens_hsa041101.94207277
14Base excision repair_Homo sapiens_hsa034101.92279459
15Mismatch repair_Homo sapiens_hsa034301.89143626
16Autoimmune thyroid disease_Homo sapiens_hsa053201.78818998
17Lysosome_Homo sapiens_hsa041421.68871391
18Chronic myeloid leukemia_Homo sapiens_hsa052201.68003035
19Ribosome_Homo sapiens_hsa030101.62723616
20Biosynthesis of amino acids_Homo sapiens_hsa012301.62431932
21Epstein-Barr virus infection_Homo sapiens_hsa051691.58049576
22Intestinal immune network for IgA production_Homo sapiens_hsa046721.52009059
23Cyanoamino acid metabolism_Homo sapiens_hsa004601.44295356
24mRNA surveillance pathway_Homo sapiens_hsa030151.39856155
25T cell receptor signaling pathway_Homo sapiens_hsa046601.38014118
26Glycosaminoglycan degradation_Homo sapiens_hsa005311.36483197
27Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.33084893
28B cell receptor signaling pathway_Homo sapiens_hsa046621.31399894
29Rheumatoid arthritis_Homo sapiens_hsa053231.31097658
30Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.29735723
31HTLV-I infection_Homo sapiens_hsa051661.29598194
32Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.29415151
33Proteasome_Homo sapiens_hsa030501.29258458
34Malaria_Homo sapiens_hsa051441.29243657
352-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.29136645
36Type I diabetes mellitus_Homo sapiens_hsa049401.28116576
37Viral carcinogenesis_Homo sapiens_hsa052031.26831027
38Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.26698534
39Acute myeloid leukemia_Homo sapiens_hsa052211.26178811
40Neurotrophin signaling pathway_Homo sapiens_hsa047221.25803168
41Staphylococcus aureus infection_Homo sapiens_hsa051501.24234581
42p53 signaling pathway_Homo sapiens_hsa041151.24104447
43Legionellosis_Homo sapiens_hsa051341.24095891
44Primary immunodeficiency_Homo sapiens_hsa053401.23645236
45Apoptosis_Homo sapiens_hsa042101.22448490
46Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.20342055
47Osteoclast differentiation_Homo sapiens_hsa043801.20180701
48Bladder cancer_Homo sapiens_hsa052191.19634368
49Salmonella infection_Homo sapiens_hsa051321.17917571
50Pentose phosphate pathway_Homo sapiens_hsa000301.17253545
51Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.17169040
52Central carbon metabolism in cancer_Homo sapiens_hsa052301.16977947
53Hematopoietic cell lineage_Homo sapiens_hsa046401.15375511
54Shigellosis_Homo sapiens_hsa051311.14399739
55RNA polymerase_Homo sapiens_hsa030201.13485787
56Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.11676073
57Nucleotide excision repair_Homo sapiens_hsa034201.09445709
58Sulfur relay system_Homo sapiens_hsa041221.09135791
59VEGF signaling pathway_Homo sapiens_hsa043701.06328897
60mTOR signaling pathway_Homo sapiens_hsa041501.04225193
61Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.03637840
62Small cell lung cancer_Homo sapiens_hsa052221.03466207
63Non-small cell lung cancer_Homo sapiens_hsa052231.02936410
64Hepatitis B_Homo sapiens_hsa051611.02827991
65Notch signaling pathway_Homo sapiens_hsa043300.98148815
66Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.97741034
67Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.97340609
68Phagosome_Homo sapiens_hsa041450.97310950
69Leishmaniasis_Homo sapiens_hsa051400.97272151
70Pyrimidine metabolism_Homo sapiens_hsa002400.95959149
71Carbon metabolism_Homo sapiens_hsa012000.95871301
72Measles_Homo sapiens_hsa051620.95833290
73HIF-1 signaling pathway_Homo sapiens_hsa040660.94270724
74MicroRNAs in cancer_Homo sapiens_hsa052060.94023539
75Hepatitis C_Homo sapiens_hsa051600.92791832
76Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.92326482
77Herpes simplex infection_Homo sapiens_hsa051680.91955962
78Regulation of autophagy_Homo sapiens_hsa041400.91204837
79Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.90525131
80Thyroid cancer_Homo sapiens_hsa052160.87475459
81Chemokine signaling pathway_Homo sapiens_hsa040620.87448919
82Cysteine and methionine metabolism_Homo sapiens_hsa002700.87280625
83NF-kappa B signaling pathway_Homo sapiens_hsa040640.87177957
84Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.87085696
85Oocyte meiosis_Homo sapiens_hsa041140.86180952
86AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.85985131
87Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.84221483
88Toxoplasmosis_Homo sapiens_hsa051450.82515553
89Non-homologous end-joining_Homo sapiens_hsa034500.79591258
90Pancreatic cancer_Homo sapiens_hsa052120.79377785
91Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.77379833
92Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.76461510
93Systemic lupus erythematosus_Homo sapiens_hsa053220.74058368
94Viral myocarditis_Homo sapiens_hsa054160.73770443
95Homologous recombination_Homo sapiens_hsa034400.72620228
96Adipocytokine signaling pathway_Homo sapiens_hsa049200.72544532
97Colorectal cancer_Homo sapiens_hsa052100.72327560
98Proteoglycans in cancer_Homo sapiens_hsa052050.68888832
99Insulin resistance_Homo sapiens_hsa049310.68611103
100African trypanosomiasis_Homo sapiens_hsa051430.68054591
101Prolactin signaling pathway_Homo sapiens_hsa049170.67884249
102Thyroid hormone signaling pathway_Homo sapiens_hsa049190.67272981
103TNF signaling pathway_Homo sapiens_hsa046680.63996478
104Renal cell carcinoma_Homo sapiens_hsa052110.63927010
105Sphingolipid metabolism_Homo sapiens_hsa006000.63924014
106Tuberculosis_Homo sapiens_hsa051520.63756685
107Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.63325222
108Basal transcription factors_Homo sapiens_hsa030220.63144221
109Endocytosis_Homo sapiens_hsa041440.62373768
110Lysine degradation_Homo sapiens_hsa003100.61800991
111Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.61233975
112Glioma_Homo sapiens_hsa052140.60972829
113Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.60550684
114Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.60217903
115Influenza A_Homo sapiens_hsa051640.59472096
116Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.57577144
117Leukocyte transendothelial migration_Homo sapiens_hsa046700.56581684
118RNA degradation_Homo sapiens_hsa030180.54333187
119Insulin signaling pathway_Homo sapiens_hsa049100.54225051
120Estrogen signaling pathway_Homo sapiens_hsa049150.53787487
121Asthma_Homo sapiens_hsa053100.53761835
122Transcriptional misregulation in cancer_Homo sapiens_hsa052020.53114714
123Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.51783253
124Jak-STAT signaling pathway_Homo sapiens_hsa046300.51448454
125Pertussis_Homo sapiens_hsa051330.51164657
126Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.50885875
127Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.49103807
128Inositol phosphate metabolism_Homo sapiens_hsa005620.47997995
129Sphingolipid signaling pathway_Homo sapiens_hsa040710.46851464
130Drug metabolism - other enzymes_Homo sapiens_hsa009830.46642907
131NOD-like receptor signaling pathway_Homo sapiens_hsa046210.45970629
132Type II diabetes mellitus_Homo sapiens_hsa049300.45771674
133Galactose metabolism_Homo sapiens_hsa000520.42863080
134FoxO signaling pathway_Homo sapiens_hsa040680.42454970
135Fructose and mannose metabolism_Homo sapiens_hsa000510.41872781
136RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.40415892
137Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.40115127
138Fanconi anemia pathway_Homo sapiens_hsa034600.39294865
139Collecting duct acid secretion_Homo sapiens_hsa049660.38692478
140Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.38540531
141Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.38281272

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