TFF2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Members of the trefoil family are characterized by having at least one copy of the trefoil motif, a 40-amino acid domain that contains three conserved disulfides. They are stable secretory proteins expressed in gastrointestinal mucosa. Their functions are not defined, but they may protect the mucosa from insults, stabilize the mucus layer and affect healing of the epithelium. The encoded protein inhibits gastric acid secretion. This gene and two other related trefoil family member genes are found in a cluster on chromosome 21. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of necroptotic process (GO:0060546)8.62122785
2labyrinthine layer blood vessel development (GO:0060716)8.29147842
3calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)8.00331783
4embryonic digestive tract morphogenesis (GO:0048557)7.89817354
5intestinal absorption (GO:0050892)7.78959245
6negative regulation of Notch signaling pathway (GO:0045746)7.77084468
7transcytosis (GO:0045056)7.75456388
8cobalamin metabolic process (GO:0009235)7.68346938
9regulation of keratinocyte proliferation (GO:0010837)7.55973402
10regulation of keratinocyte differentiation (GO:0045616)7.45807026
11regulation of phospholipase A2 activity (GO:0032429)7.42081635
12peptidyl-proline hydroxylation (GO:0019511)7.09599344
13negative regulation of necrotic cell death (GO:0060547)6.92511626
14sterol catabolic process (GO:0016127)6.90824431
15cholesterol catabolic process (GO:0006707)6.90824431
16negative regulation of epithelial to mesenchymal transition (GO:0010719)6.70170544
17regulation of necroptotic process (GO:0060544)6.52585321
18trabecula formation (GO:0060343)6.34711849
19receptor guanylyl cyclase signaling pathway (GO:0007168)6.05997771
20glycolipid catabolic process (GO:0019377)5.98734891
21cysteine metabolic process (GO:0006534)5.86767163
22branched-chain amino acid catabolic process (GO:0009083)5.69748732
23membrane lipid catabolic process (GO:0046466)5.62080858
24valine metabolic process (GO:0006573)5.60591403
25cellular response to cadmium ion (GO:0071276)5.53740105
26morphogenesis of embryonic epithelium (GO:0016331)5.52691979
27protein hydroxylation (GO:0018126)5.45887070
28cellular response to arsenic-containing substance (GO:0071243)5.41756879
29placenta blood vessel development (GO:0060674)5.31485012
30lung epithelial cell differentiation (GO:0060487)5.21153974
31proline biosynthetic process (GO:0006561)5.19598753
32Golgi transport vesicle coating (GO:0048200)5.12038478
33COPI coating of Golgi vesicle (GO:0048205)5.12038478
34lung cell differentiation (GO:0060479)4.99478643
35protein autoprocessing (GO:0016540)4.99142183
36branched-chain amino acid metabolic process (GO:0009081)4.95855371
37tight junction assembly (GO:0070830)4.91660859
38leukotriene biosynthetic process (GO:0019370)4.79990546
39regulation of necrotic cell death (GO:0010939)4.79969617
40ceramide catabolic process (GO:0046514)4.79832668
41regulation of cell maturation (GO:1903429)4.76698624
42neural crest cell migration (GO:0001755)4.74001215
43negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)4.73161498
44mitochondrial calcium ion transport (GO:0006851)4.66999916
45retinal metabolic process (GO:0042574)4.65999780
46cellular modified amino acid catabolic process (GO:0042219)4.53664771
47negative regulation of epithelial cell differentiation (GO:0030857)4.53272608
48intestinal epithelial cell development (GO:0060576)4.47245914
49cGMP biosynthetic process (GO:0006182)4.45804586
50digestive system process (GO:0022600)4.45188300
51maintenance of gastrointestinal epithelium (GO:0030277)4.40740839
52antibacterial humoral response (GO:0019731)4.40309391
53regulation of epidermal cell differentiation (GO:0045604)4.34855078
54negative regulation of meiotic cell cycle (GO:0051447)4.34359339
55neutrophil mediated immunity (GO:0002446)4.30462901
56activation of signaling protein activity involved in unfolded protein response (GO:0006987)4.29879079
57positive regulation of heat generation (GO:0031652)4.24260825
58zinc ion transport (GO:0006829)4.20094267
59GDP-mannose metabolic process (GO:0019673)4.19483405
60daunorubicin metabolic process (GO:0044597)4.16007942
61polyketide metabolic process (GO:0030638)4.16007942
62doxorubicin metabolic process (GO:0044598)4.16007942
63aspartate family amino acid catabolic process (GO:0009068)4.13335021
64antimicrobial humoral response (GO:0019730)4.10526040
65positive regulation of nuclease activity (GO:0032075)4.09307957
66response to endoplasmic reticulum stress (GO:0034976)4.09218728
67protein maturation by protein folding (GO:0022417)4.07443294
68negative regulation of DNA-templated transcription, elongation (GO:0032785)4.07426130
69signal peptide processing (GO:0006465)4.06271746
70regulation of fever generation (GO:0031620)4.05231199
71positive regulation of prostaglandin secretion (GO:0032308)3.99467837
724-hydroxyproline metabolic process (GO:0019471)3.92392492
73endoplasmic reticulum unfolded protein response (GO:0030968)3.90891085
74serine family amino acid biosynthetic process (GO:0009070)3.89510074
75O-glycan processing (GO:0016266)3.87383050
76homocysteine metabolic process (GO:0050667)3.85077351
77histone H2B ubiquitination (GO:0033523)3.85071748
78negative regulation of stem cell differentiation (GO:2000737)3.85047047
79maintenance of protein localization in organelle (GO:0072595)3.83595202
80fucose catabolic process (GO:0019317)3.79799996
81L-fucose metabolic process (GO:0042354)3.79799996
82L-fucose catabolic process (GO:0042355)3.79799996
83diterpenoid biosynthetic process (GO:0016102)3.79165166
84cellular response to unfolded protein (GO:0034620)3.79114377
85regulation of nuclease activity (GO:0032069)3.72175135
86negative regulation of epidermal cell differentiation (GO:0045605)3.70909831
87aminoglycoside antibiotic metabolic process (GO:0030647)3.66198536
88innate immune response in mucosa (GO:0002227)3.65333664
89cellular aldehyde metabolic process (GO:0006081)3.64398947
90steroid catabolic process (GO:0006706)3.62964239
91sulfur amino acid catabolic process (GO:0000098)3.61756633
92creatine metabolic process (GO:0006600)3.60564976
93ER-nucleus signaling pathway (GO:0006984)3.59910851
94cellular response to topologically incorrect protein (GO:0035967)3.58449843
95coenzyme catabolic process (GO:0009109)3.57232671
96icosanoid secretion (GO:0032309)3.53444478
97arachidonic acid secretion (GO:0050482)3.53444478
98glutamine metabolic process (GO:0006541)3.51535958
99primary alcohol catabolic process (GO:0034310)3.50135723
100glutathione derivative biosynthetic process (GO:1901687)3.47646923
101glutathione derivative metabolic process (GO:1901685)3.47646923
102regulation of Notch signaling pathway (GO:0008593)3.47243570
103columnar/cuboidal epithelial cell differentiation (GO:0002065)3.43492518
104proline metabolic process (GO:0006560)3.41369389
105succinate metabolic process (GO:0006105)3.37414285
106positive regulation of protein homooligomerization (GO:0032464)3.36761767
107ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)3.35622929
108phosphatidylserine acyl-chain remodeling (GO:0036150)3.32777870
109potassium ion export (GO:0071435)3.31300522
110leukotriene metabolic process (GO:0006691)3.29596371
111myeloid leukocyte mediated immunity (GO:0002444)3.29281078
112epithelial structure maintenance (GO:0010669)3.26628922
113regulation of prostaglandin secretion (GO:0032306)3.26553601
114sulfation (GO:0051923)3.24420747
115positive regulation of NF-kappaB import into nucleus (GO:0042346)3.23791416
116regulation of heat generation (GO:0031650)3.22903737
117cellular response to zinc ion (GO:0071294)3.22848541
118COPII vesicle coating (GO:0048208)3.20861032
119cyclooxygenase pathway (GO:0019371)3.20758896
120bundle of His cell to Purkinje myocyte communication (GO:0086069)3.17910933
121lung secretory cell differentiation (GO:0061140)3.17790021
122phosphatidylinositol acyl-chain remodeling (GO:0036149)3.17409844
123erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.15747872
124L-phenylalanine catabolic process (GO:0006559)3.15747872
125positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003603.14681098
126serine family amino acid metabolic process (GO:0009069)3.12313059
127negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class 3.11800184
128response to unfolded protein (GO:0006986)3.11754188
129sphingolipid catabolic process (GO:0030149)3.11145722
130phosphatidylglycerol acyl-chain remodeling (GO:0036148)3.10412238
131ER overload response (GO:0006983)3.09123067
132ethanol oxidation (GO:0006069)3.07314954
133negative regulation of fatty acid biosynthetic process (GO:0045717)3.04177727
134retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.03467072
135L-serine metabolic process (GO:0006563)3.02160702
136regulation of oxidative stress-induced intrinsic apoptotic signaling pathway (GO:1902175)3.01170199
137biotin metabolic process (GO:0006768)3.01019097
138L-phenylalanine metabolic process (GO:0006558)3.00965129
139erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.00965129
140protein O-linked glycosylation (GO:0006493)3.00127646
141primary alcohol metabolic process (GO:0034308)2.99778145
142glandular epithelial cell differentiation (GO:0002067)2.99754852
143response to topologically incorrect protein (GO:0035966)2.99087241
144protein N-linked glycosylation via asparagine (GO:0018279)2.98386693
145cell redox homeostasis (GO:0045454)2.97469933
146peptidyl-asparagine modification (GO:0018196)2.96407229
147terpenoid biosynthetic process (GO:0016114)2.95412271
148mitochondrion distribution (GO:0048311)2.94556767
149icosanoid transport (GO:0071715)2.94248311
150fatty acid derivative transport (GO:1901571)2.94248311
151nucleotide-sugar biosynthetic process (GO:0009226)2.92003060
152regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator 2.91153161
153endocrine pancreas development (GO:0031018)2.90541125
154positive regulation of interferon-gamma biosynthetic process (GO:0045078)2.86811477
155natural killer cell mediated immunity (GO:0002228)2.83630674
156natural killer cell mediated cytotoxicity (GO:0042267)2.83630674
157regulation of epidermis development (GO:0045682)2.81283409
158progesterone metabolic process (GO:0042448)2.80787585
159fucose metabolic process (GO:0006004)2.80365615
160cGMP metabolic process (GO:0046068)2.78199032
161retinol metabolic process (GO:0042572)2.65411000
162negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.63665546
163positive regulation of icosanoid secretion (GO:0032305)2.59820061
164histone H2A ubiquitination (GO:0033522)2.57494432
165glycoside metabolic process (GO:0016137)2.56185415
166regulation of epithelial to mesenchymal transition (GO:0010717)2.54464909
167regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.53235894
168prostanoid metabolic process (GO:0006692)2.50401316
169prostaglandin metabolic process (GO:0006693)2.50401316
170barbed-end actin filament capping (GO:0051016)2.49329527
171ethanol metabolic process (GO:0006067)2.45686917
172fucosylation (GO:0036065)2.41112634
173positive regulation of DNA repair (GO:0045739)2.40701906
174negative regulation of transcription by competitive promoter binding (GO:0010944)19.2197970
175intestinal cholesterol absorption (GO:0030299)15.7268207
176exocrine pancreas development (GO:0031017)14.7188717
177* digestion (GO:0007586)14.1897991
178positive regulation of translational initiation (GO:0045948)12.8308234
179protein retention in ER lumen (GO:0006621)11.6439454
180maintenance of protein localization in endoplasmic reticulum (GO:0035437)10.8355987
181negative regulation of epidermis development (GO:0045683)10.6604241
182heart trabecula formation (GO:0060347)10.4020657
183morphogenesis of an epithelial fold (GO:0060571)10.2417535

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat6.90209779
2ESR1_20079471_ChIP-ChIP_T-47D_Human4.61094814
3STAT6_21828071_ChIP-Seq_BEAS2B_Human4.24548683
4ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.16294067
5ZNF263_19887448_ChIP-Seq_K562_Human3.98300342
6SOX2_27498859_Chip-Seq_STOMACH_Mouse3.93157344
7ESR1_21235772_ChIP-Seq_MCF-7_Human3.49459678
8ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse3.16932545
9GATA4_25053715_ChIP-Seq_YYC3_Human3.12520310
10ESR2_21235772_ChIP-Seq_MCF-7_Human3.06144710
11HIF1A_21447827_ChIP-Seq_MCF-7_Human2.91742305
12IRF8_22096565_ChIP-ChIP_GC-B_Human2.87754713
13ZNF652_21678463_ChIP-ChIP_ZR75-1_Human2.86990146
14PPARA_22158963_ChIP-Seq_LIVER_Mouse2.80872115
15* CDX2_20551321_ChIP-Seq_CACO-2_Human2.74024246
16ERG_21242973_ChIP-ChIP_JURKAT_Human2.69564041
17FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.59574542
18* RXR_22158963_ChIP-Seq_LIVER_Mouse2.49925827
19FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.48661258
20GATA6_25053715_ChIP-Seq_YYC3_Human2.44263525
21STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.35169885
22TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.31206838
23LXR_22158963_ChIP-Seq_LIVER_Mouse2.29962395
24CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.17925404
25SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.13220820
26GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.04101711
27KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.03888747
28KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.03888747
29KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.03888747
30RARG_19884340_ChIP-ChIP_MEFs_Mouse2.03823399
31PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.02976077
32EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.95905925
33PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.91527498
34TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.84629048
35CDX2_22108803_ChIP-Seq_LS180_Human1.84566721
36SOX2_20726797_ChIP-Seq_SW620_Human1.80968673
37EGR1_19032775_ChIP-ChIP_M12_Human1.73630484
38SMAD4_21741376_ChIP-Seq_HESCs_Human1.71675914
39SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.70808953
40IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.67404538
41AHR_22903824_ChIP-Seq_MCF-7_Human1.64981348
42P63_26484246_Chip-Seq_KERATINOCYTES_Human1.62051278
43HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.58305101
44NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.55667135
45FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.53720553
46RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.53650257
47TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.53518371
48TP63_17297297_ChIP-ChIP_HaCaT_Human1.53139016
49SMAD3_21741376_ChIP-Seq_HESCs_Human1.50500593
50E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.47811351
51TCF4_18268006_ChIP-ChIP_LS174T_Human1.47514870
52PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.44831681
53ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.44150066
54CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.43469437
55LXR_22292898_ChIP-Seq_THP-1_Human1.41100754
56FOXA1_25329375_ChIP-Seq_VCAP_Human1.40159266
57FOXA1_27270436_Chip-Seq_PROSTATE_Human1.40159266
58AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.36585882
59RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.33121256
60GATA1_22025678_ChIP-Seq_K562_Human1.29908524
61CJUN_26792858_Chip-Seq_BT549_Human1.28978703
62RUNX1_27514584_Chip-Seq_MCF-7_Human1.28975078
63TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.27418670
64PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.27226759
65PPAR_26484153_Chip-Seq_NCI-H1993_Human1.26326582
66SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.25953537
67SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.25953537
68EP300_21415370_ChIP-Seq_HL-1_Mouse1.25237772
69CREB1_26743006_Chip-Seq_LNCaP_Human1.25105110
70ATF3_27146783_Chip-Seq_COLON_Human1.24567609
71GATA3_24758297_ChIP-Seq_MCF-7_Human1.24349715
72ARNT_22903824_ChIP-Seq_MCF-7_Human1.22740268
73* SA1_27219007_Chip-Seq_ERYTHROID_Human1.21618292
74BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.20112870
75TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.19326965
76RACK7_27058665_Chip-Seq_MCF-7_Human1.18573303
77ERG_20517297_ChIP-Seq_VCAP_Human1.17645559
78NOTCH1_21737748_ChIP-Seq_TLL_Human1.17615413
79FOXA1_25552417_ChIP-Seq_VCAP_Human1.17570007
80EGR1_23403033_ChIP-Seq_LIVER_Mouse1.16964826
81ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.16562888
82TP63_22573176_ChIP-Seq_HFKS_Human1.16538470
83P68_20966046_ChIP-Seq_HELA_Human1.16409465
84STAT1_20625510_ChIP-Seq_HELA_Human1.15741323
85CHD1_26751641_Chip-Seq_LNCaP_Human1.15634927
86NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.14614146
87SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.13363642
88P53_22127205_ChIP-Seq_FIBROBLAST_Human1.12551939
89FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.12028393
90KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.11147746
91BCOR_27268052_Chip-Seq_Bcells_Human1.09562095
92KLF5_25053715_ChIP-Seq_YYC3_Human1.09102865
93ELF5_23300383_ChIP-Seq_T47D_Human1.08387449
94CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.07868352
95FOXA2_19822575_ChIP-Seq_HepG2_Human1.07578704
96FOXH1_21741376_ChIP-Seq_ESCs_Human1.06109276
97FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.05801825
98FOXO3_23340844_ChIP-Seq_DLD1_Human1.05384101
99CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04539519
100FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.03897878
101MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.03711904
102CLOCK_20551151_ChIP-Seq_293T_Human1.03602602
103ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.03449669
104SOX2_21211035_ChIP-Seq_LN229_Human1.02730630
105* SMAD4_21741376_ChIP-Seq_EPCs_Human1.02434480
106KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.02011448
107SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.01349560
108FOXM1_26456572_ChIP-Seq_MCF-7_Human1.01230238
109NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.00980718
110* P53_21459846_ChIP-Seq_SAOS-2_Human1.00267044
111JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.99838262
112CTCF_27219007_Chip-Seq_Bcells_Human0.99415164
113TCF4_22108803_ChIP-Seq_LS180_Human0.98333674
114DNAJC2_21179169_ChIP-ChIP_NT2_Human0.97728857
115OCT4_20526341_ChIP-Seq_ESCs_Human0.96279821
116Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.96225775
117IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.96003650
118CBP_20019798_ChIP-Seq_JUKART_Human0.96003650
119EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.95170530
120SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.94252953
121* FOXH1_21741376_ChIP-Seq_EPCs_Human0.93726620
122FLI1_27457419_Chip-Seq_LIVER_Mouse0.91765026
123ERA_21632823_ChIP-Seq_H3396_Human0.91573304
124TCF3_18692474_ChIP-Seq_MEFs_Mouse0.89197302
125PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.89072805
126GATA2_21666600_ChIP-Seq_HMVEC_Human0.88841401
127ISL1_27105846_Chip-Seq_CPCs_Mouse0.87887436
128CTCF_20526341_ChIP-Seq_ESCs_Human0.86600243
129TBX20_22328084_ChIP-Seq_HEART_Mouse0.86006469
130TBX20_22080862_ChIP-Seq_HEART_Mouse0.86006469
131MYC_19829295_ChIP-Seq_ESCs_Human0.85860023
132JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.85837843
133PCGF2_27294783_Chip-Seq_ESCs_Mouse0.85003624
134TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.84087961
135FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.82934468
136GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.82639688
137SMC4_20622854_ChIP-Seq_HELA_Human0.82464681
138PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.81267715
139* ESET_19884257_ChIP-Seq_ESCs_Mouse0.81221464
140* CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.81170347
141ETS1_21867929_ChIP-Seq_TH2_Mouse0.81084511
142P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.80698776
143CDX2_19796622_ChIP-Seq_MESCs_Mouse0.80606541
144* SOX3_22085726_ChIP-Seq_MUSCLE_Mouse0.80049289
145GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.79832697
146TDRD3_21172665_ChIP-Seq_MCF-7_Human0.79817666
147* CEBPB_22108803_ChIP-Seq_LS180_Human0.78545897
148ZFX_18555785_Chip-Seq_ESCs_Mouse0.77981056
149PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.77437811
150PIAS1_25552417_ChIP-Seq_VCAP_Human0.77312797
151TAF2_19829295_ChIP-Seq_ESCs_Human0.77268140
152NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.76680521
153ZNF217_24962896_ChIP-Seq_MCF-7_Human0.75052971
154NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.74741632
155SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.74579645
156ZNF274_21170338_ChIP-Seq_K562_Hela0.74295609
157TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.73959432
158IRF1_19129219_ChIP-ChIP_H3396_Human0.73489399

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005083_abnormal_biliary_tract8.67007834
2MP0001666_abnormal_nutrient_absorption8.37999414
3MP0008004_abnormal_stomach_pH7.93420289
4MP0000462_abnormal_digestive_system6.78518136
5MP0005365_abnormal_bile_salt5.87103072
6MP0005220_abnormal_exocrine_pancreas5.45081889
7MP0003938_abnormal_ear_development4.30924918
8MP0003868_abnormal_feces_composition4.27098507
9MP0005084_abnormal_gallbladder_morpholo4.03038984
10* MP0001664_abnormal_digestion3.37456369
11MP0003119_abnormal_digestive_system3.37341500
12MP0001873_stomach_inflammation3.36886279
13MP0005085_abnormal_gallbladder_physiolo3.27185303
14* MP0000490_abnormal_crypts_of2.54036706
15MP0002693_abnormal_pancreas_physiology2.30699817
16MP0005666_abnormal_adipose_tissue2.07306212
17MP0003959_abnormal_lean_body2.06762486
18MP0003806_abnormal_nucleotide_metabolis2.03700415
19MP0004264_abnormal_extraembryonic_tissu1.99715090
20* MP0000470_abnormal_stomach_morphology1.85193076
21MP0010234_abnormal_vibrissa_follicle1.75661880
22MP0003705_abnormal_hypodermis_morpholog1.72499021
23MP0002139_abnormal_hepatobiliary_system1.65166426
24MP0004036_abnormal_muscle_relaxation1.55285436
25MP0002277_abnormal_respiratory_mucosa1.54193743
26MP0002909_abnormal_adrenal_gland1.49614159
27MP0005670_abnormal_white_adipose1.46195676
28MP0005448_abnormal_energy_balance1.39681052
29MP0001944_abnormal_pancreas_morphology1.34282615
30MP0003638_abnormal_response/metabolism_1.33952716
31MP0002233_abnormal_nose_morphology1.27375370
32MP0002118_abnormal_lipid_homeostasis1.27278538
33MP0004233_abnormal_muscle_weight1.25730177
34MP0002138_abnormal_hepatobiliary_system1.23078148
35MP0003186_abnormal_redox_activity1.14973388
36MP0001270_distended_abdomen1.11879447
37MP0005332_abnormal_amino_acid1.09688807
38MP0000566_synostosis1.07924014
39MP0005275_abnormal_skin_tensile1.07733103
40MP0005451_abnormal_body_composition1.07658458
41MP0009379_abnormal_foot_pigmentation1.04841881
42MP0003252_abnormal_bile_duct1.03902288
43MP0005408_hypopigmentation1.01094958
44MP0000343_altered_response_to0.97992951
45MP0006054_spinal_hemorrhage0.93983728
46MP0005409_darkened_coat_color0.91268783
47MP0002078_abnormal_glucose_homeostasis0.91042113
48MP0009250_abnormal_appendicular_skeleto0.90221104
49MP0002796_impaired_skin_barrier0.87644916
50MP0009384_cardiac_valve_regurgitation0.86442016
51MP0009840_abnormal_foam_cell0.86026367
52MP0003763_abnormal_thymus_physiology0.79734101
53MP0001286_abnormal_eye_development0.78930213
54MP0009643_abnormal_urine_homeostasis0.77718020
55MP0000428_abnormal_craniofacial_morphol0.76091874
56MP0008789_abnormal_olfactory_epithelium0.75919642
57MP0000372_irregular_coat_pigmentation0.74245357
58MP0004484_altered_response_of0.73847660
59* MP0005165_increased_susceptibility_to0.72682976
60MP0003953_abnormal_hormone_level0.72498017
61MP0005503_abnormal_tendon_morphology0.72370655
62* MP0001663_abnormal_digestive_system0.71637463
63MP0002102_abnormal_ear_morphology0.71481230
64MP0010329_abnormal_lipoprotein_level0.71195052
65MP0004043_abnormal_pH_regulation0.69840352
66MP0000003_abnormal_adipose_tissue0.69828998
67MP0002163_abnormal_gland_morphology0.69219210
68MP0000613_abnormal_salivary_gland0.68709811
69MP0002877_abnormal_melanocyte_morpholog0.66977402
70MP0005508_abnormal_skeleton_morphology0.66732007
71MP0005164_abnormal_response_to0.64678540
72MP0008875_abnormal_xenobiotic_pharmacok0.63693311
73MP0004782_abnormal_surfactant_physiolog0.63118249
74MP0005535_abnormal_body_temperature0.63102183
75MP0008961_abnormal_basal_metabolism0.62321502
76MP0004185_abnormal_adipocyte_glucose0.61686333
77MP0002735_abnormal_chemical_nociception0.59198544
78MP0006036_abnormal_mitochondrial_physio0.58148151
79MP0002971_abnormal_brown_adipose0.58120437
80* MP0005381_digestive/alimentary_phenotyp0.56810750
81MP0000163_abnormal_cartilage_morphology0.56763958
82MP0005058_abnormal_lysosome_morphology0.56312292
83MP0002098_abnormal_vibrissa_morphology0.55650386
84MP0000598_abnormal_liver_morphology0.55596936
85MP0001845_abnormal_inflammatory_respons0.55079147
86MP0008438_abnormal_cutaneous_collagen0.54699768
87MP0000371_diluted_coat_color0.54675839
88MP0005452_abnormal_adipose_tissue0.54591189
89MP0002736_abnormal_nociception_after0.54300904
90MP0002234_abnormal_pharynx_morphology0.53967493
91MP0009764_decreased_sensitivity_to0.53956098
92MP0005319_abnormal_enzyme/_coenzyme0.52436359
93MP0000609_abnormal_liver_physiology0.52415963
94MP0010630_abnormal_cardiac_muscle0.52164228
95MP0005636_abnormal_mineral_homeostasis0.51880610
96MP0005310_abnormal_salivary_gland0.51156931
97MP0005394_taste/olfaction_phenotype0.50135891
98MP0005499_abnormal_olfactory_system0.50135891
99MP0000681_abnormal_thyroid_gland0.49697076
100MP0003656_abnormal_erythrocyte_physiolo0.47978750
101MP0002060_abnormal_skin_morphology0.47791812
102MP0002282_abnormal_trachea_morphology0.46955391
103MP0002876_abnormal_thyroid_physiology0.46786088
104MP0000367_abnormal_coat/_hair0.46403780
105MP0002928_abnormal_bile_duct0.45642342
106MP0009765_abnormal_xenobiotic_induced0.43624021
107MP0000750_abnormal_muscle_regeneration0.42236585
108MP0001243_abnormal_dermal_layer0.41810183
109MP0004883_abnormal_blood_vessel0.41289681
110MP0005023_abnormal_wound_healing0.41140352
111MP0010155_abnormal_intestine_physiology0.40596501
112MP0001346_abnormal_lacrimal_gland0.40215753
113MP0000467_abnormal_esophagus_morphology0.40122454
114MP0000858_altered_metastatic_potential0.39757253
115MP0003935_abnormal_craniofacial_develop0.38662485
116MP0002128_abnormal_blood_circulation0.38285287
117MP0003183_abnormal_peptide_metabolism0.38235747
118MP0004272_abnormal_basement_membrane0.38142030
119MP0003329_amyloid_beta_deposits0.38119518
120MP0005360_urolithiasis0.38075395
121MP0001731_abnormal_postnatal_growth0.37790366
122MP0005375_adipose_tissue_phenotype0.37210719
123MP0001764_abnormal_homeostasis0.36465957
124MP0003283_abnormal_digestive_organ0.36118992
125MP0002089_abnormal_postnatal_growth/wei0.35675727
126MP0000377_abnormal_hair_follicle0.35571481
127MP0004147_increased_porphyrin_level0.33951833
128MP0009642_abnormal_blood_homeostasis0.33837733
129MP0000627_abnormal_mammary_gland0.33551321
130MP0003448_altered_tumor_morphology0.33221094
131MP0002295_abnormal_pulmonary_circulatio0.33003767
132MP0005584_abnormal_enzyme/coenzyme_acti0.32363620
133MP0005257_abnormal_intraocular_pressure0.32313980
134MP0000477_abnormal_intestine_morphology0.32183970
135MP0003724_increased_susceptibility_to0.31361098
136MP0005334_abnormal_fat_pad0.31206421
137MP0003795_abnormal_bone_structure0.27822689
138MP0003191_abnormal_cellular_cholesterol0.27703507
139MP0001216_abnormal_epidermal_layer0.27424076
140MP0000647_abnormal_sebaceous_gland0.27135035
141MP0010678_abnormal_skin_adnexa0.26894982
142MP0005501_abnormal_skin_physiology0.25662561
143MP0009931_abnormal_skin_appearance0.24906811
144MP0000579_abnormal_nail_morphology0.24820477
145MP0003453_abnormal_keratinocyte_physiol0.24732493
146MP0004130_abnormal_muscle_cell0.24592500
147MP0008469_abnormal_protein_level0.23772555
148MP0000762_abnormal_tongue_morphology0.22763719
149MP0008872_abnormal_physiological_respon0.22330129
150MP0003045_fibrosis0.22179124
151MP0001756_abnormal_urination0.22085005
152MP0004947_skin_inflammation0.22021418
153MP0010771_integument_phenotype0.21604591

Predicted human phenotypes

RankGene SetZ-score
1Broad metatarsal (HP:0001783)9.12138966
2Vertebral arch anomaly (HP:0008438)9.06357293
3Short nail (HP:0001799)8.60660556
4Steatorrhea (HP:0002570)7.62963220
5Abnormality of the lumbar spine (HP:0100712)6.68324773
6Gout (HP:0001997)6.67604474
7Fat malabsorption (HP:0002630)6.43592596
8Mesomelia (HP:0003027)6.32555847
9Radial bowing (HP:0002986)5.98050493
10Redundant skin (HP:0001582)5.71341624
11Thoracic kyphosis (HP:0002942)5.61952114
12Short chin (HP:0000331)5.43142272
13Decreased subcutaneous fat (HP:0001002)5.37539622
14Long toe (HP:0010511)4.91536669
15Abnormality of subcutaneous fat tissue (HP:0001001)4.80268054
16Type I diabetes mellitus (HP:0100651)4.68505283
17Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)4.52303091
18Exocrine pancreatic insufficiency (HP:0001738)4.50953500
19Maternal diabetes (HP:0009800)4.37793181
20Bowing of the arm (HP:0006488)4.29249083
21Bowed forearm bones (HP:0003956)4.29249083
22Abnormality of the intrinsic pathway (HP:0010989)4.13870014
23Right ventricular cardiomyopathy (HP:0011663)4.12672785
24Hypoplasia of the pons (HP:0012110)4.08906006
25Abnormality of the thoracic spine (HP:0100711)3.96111222
26Tubulointerstitial nephritis (HP:0001970)3.94289517
27Abnormality of the pons (HP:0007361)3.81217806
28Ovoid vertebral bodies (HP:0003300)3.80274191
29Pancreatitis (HP:0001733)3.71732600
30Broad hallux (HP:0010055)3.63603742
31Abnormality of aromatic amino acid family metabolism (HP:0004338)3.56904422
32Abnormal pancreas size (HP:0012094)3.53510396
33Cortical dysplasia (HP:0002539)3.48915145
34Ketosis (HP:0001946)3.48542994
35Tubulointerstitial fibrosis (HP:0005576)3.43329379
36Premature skin wrinkling (HP:0100678)3.43248778
37Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)3.41505479
38Joint stiffness (HP:0001387)3.38042259
39Ketoacidosis (HP:0001993)3.32317256
40Hyperuricemia (HP:0002149)3.27976788
41Increased purine levels (HP:0004368)3.27976788
42Abnormal number of erythroid precursors (HP:0012131)3.23006694
43Hyperglycinemia (HP:0002154)3.15778083
44Long foot (HP:0001833)3.09661614
45Abnormality of cells of the erythroid lineage (HP:0012130)3.07895229
46Abnormality of the epiphyses of the hand (HP:0005924)3.01030815
47Renal salt wasting (HP:0000127)2.97227957
48Hypoproteinemia (HP:0003075)2.95106795
49Hyperglycinuria (HP:0003108)2.92758519
50Broad toe (HP:0001837)2.91883625
51Abnormality of sulfur amino acid metabolism (HP:0004339)2.89568294
52Abnormality involving the epiphyses of the upper limbs (HP:0003839)2.84500739
53Flared metaphyses (HP:0003015)2.83328224
54Hypoglycemic coma (HP:0001325)2.73231891
55Exercise-induced myalgia (HP:0003738)2.71774786
56Limited elbow extension (HP:0001377)2.70420470
57Carpal bone hypoplasia (HP:0001498)2.69591056
58Amyloidosis (HP:0011034)2.66972856
59Abnormality of glycine metabolism (HP:0010895)2.65989715
60Abnormality of serine family amino acid metabolism (HP:0010894)2.65989715
61Prenatal maternal abnormality (HP:0002686)2.62989421
62Hypoplasia of the radius (HP:0002984)2.62232828
63Ventricular fibrillation (HP:0001663)2.59110988
64Abnormal tarsal ossification (HP:0008369)2.55716997
65Follicular hyperkeratosis (HP:0007502)2.51883005
66Abnormality of fatty-acid metabolism (HP:0004359)2.51054435
67Short metatarsal (HP:0010743)2.49517453
68Megaloblastic anemia (HP:0001889)2.46522465
69Abnormality of the common coagulation pathway (HP:0010990)2.45811015
70Abnormality of endocrine pancreas physiology (HP:0012093)2.45567960
71Abnormality of the pancreatic islet cells (HP:0006476)2.45567960
72Abnormality of purine metabolism (HP:0004352)2.44775021
73Fatigue (HP:0012378)2.43317827
74Esophageal varix (HP:0002040)2.39745485
75Abnormal protein N-linked glycosylation (HP:0012347)2.37213046
76Abnormal protein glycosylation (HP:0012346)2.37213046
77Abnormal glycosylation (HP:0012345)2.37213046
78Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.37213046
79Vacuolated lymphocytes (HP:0001922)2.35438951
80Abnormality of carpal bone ossification (HP:0006257)2.34063094
81Syncope (HP:0001279)2.32440280
82Reduced antithrombin III activity (HP:0001976)2.29244296
83Progressive muscle weakness (HP:0003323)2.28293935
84Abnormality of the renal cortex (HP:0011035)2.25106388
85Optic nerve hypoplasia (HP:0000609)2.22808225
86Tubular atrophy (HP:0000092)2.22730077
87Rhabdomyolysis (HP:0003201)2.20004611
88Myoglobinuria (HP:0002913)2.18273485
89Pectus carinatum (HP:0000768)2.12873458
90Congenital ichthyosiform erythroderma (HP:0007431)2.12517130
91Forearm undergrowth (HP:0009821)2.10939689
92Sprengel anomaly (HP:0000912)2.10358257
93Late onset (HP:0003584)2.10284469
94Aplasia/Hypoplasia of metatarsal bones (HP:0001964)2.09846086
95Palpitations (HP:0001962)2.08737862
96Dysostosis multiplex (HP:0000943)2.05270322
97Opisthotonus (HP:0002179)2.04996590
98Lethargy (HP:0001254)2.04206902
99Methylmalonic aciduria (HP:0012120)2.04061423
100Acute hepatic failure (HP:0006554)2.03625808
101Vascular calcification (HP:0004934)2.03066151
102Hypoglycemic seizures (HP:0002173)2.01454048
103Azoospermia (HP:0000027)13.7155551
104Abnormal spermatogenesis (HP:0008669)10.3304489
105Abnormality of the vitamin B12 metabolism (HP:0004341)1.98650458
106Acute encephalopathy (HP:0006846)1.98509504
107Abnormality of methionine metabolism (HP:0010901)1.96474603
108Abnormality of dicarboxylic acid metabolism (HP:0010995)1.95897505
109Dicarboxylic aciduria (HP:0003215)1.95897505
110Ankyloglossia (HP:0010296)1.94514425
111Lumbar hyperlordosis (HP:0002938)1.93814485
112Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.93389282
113Prolonged QT interval (HP:0001657)1.92675631
114Barrel-shaped chest (HP:0001552)1.92275061
115Flat acetabular roof (HP:0003180)1.91608801
116Abnormality of vitamin B metabolism (HP:0004340)1.91502869
117Periodontitis (HP:0000704)1.91150217
118Tubulointerstitial abnormality (HP:0001969)1.90615797
119Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.89575723
120Myopathic facies (HP:0002058)1.89183346
121Glomerulosclerosis (HP:0000096)1.89060602
122Hyperammonemia (HP:0001987)1.88875993
123Large hands (HP:0001176)1.87823818
124Hypoplasia of the odontoid process (HP:0003311)1.86615954
125Infantile muscular hypotonia (HP:0008947)1.86199727
126Small epiphyses (HP:0010585)1.84279316
127Myocardial infarction (HP:0001658)1.84265163
128Cardiovascular calcification (HP:0011915)1.84213699
129Conjugated hyperbilirubinemia (HP:0002908)1.83700398
130Hepatic necrosis (HP:0002605)1.81831018
131Ankle clonus (HP:0011448)1.81330795
132Congenital glaucoma (HP:0001087)1.81062322
133Hepatocellular necrosis (HP:0001404)1.80837205
134Beaking of vertebral bodies (HP:0004568)1.80512676
135Intrahepatic cholestasis (HP:0001406)1.80337130
136Hypotension (HP:0002615)1.79572679
137Cerebral edema (HP:0002181)1.79258893
138Abnormality of renal excretion (HP:0011036)1.76478890
139Pili torti (HP:0003777)1.76244062
140Abnormal foot bone ossification (HP:0010675)1.75259659
141Broad finger (HP:0001500)1.74763411
142Cortical visual impairment (HP:0100704)1.74543822
143Arterial tortuosity (HP:0005116)1.73409284
144Abnormal hand bone ossification (HP:0010660)1.71054253
145Tongue fasciculations (HP:0001308)1.68156587
146Broad phalanx (HP:0006009)1.67726839
147Arachnodactyly (HP:0001166)1.67515101
148Muscle stiffness (HP:0003552)1.66532493
149High anterior hairline (HP:0009890)1.57183455
150Abnormal pupillary function (HP:0007686)1.57061870
151Broad long bones (HP:0005622)1.52884361
152Abnormality of glycolysis (HP:0004366)1.51218873
153Renal hypoplasia (HP:0000089)1.50512811
154Abnormality of mucopolysaccharide metabolism (HP:0011020)1.50487713
155Abnormality of polysaccharide metabolism (HP:0011012)1.50487713
156Abnormality of glycosaminoglycan metabolism (HP:0004371)1.50487713
157Abnormal ossification of hand bones (HP:0005921)1.50251494
158Soft skin (HP:0000977)1.49448234
159Disproportionate tall stature (HP:0001519)1.47929760
160Urinary glycosaminoglycan excretion (HP:0003541)1.46161158
161Mucopolysacchariduria (HP:0008155)1.46161158
162Abnormality of abdominal situs (HP:0011620)1.44690879
163Abdominal situs inversus (HP:0003363)1.44690879
164Joint laxity (HP:0001388)1.42668598
165Hyperventilation (HP:0002883)1.41688227
166Ventricular arrhythmia (HP:0004308)1.41665383
167Vascular tortuosity (HP:0004948)1.39400277
168Increased density of long bones (HP:0006392)1.37816903
169Cerebral palsy (HP:0100021)1.34863742
170Osteopenia (HP:0000938)1.32138883
171Epiphyseal stippling (HP:0010655)1.31988453

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK8.95775190
2ERN15.14944536
3ERBB44.58641231
4PBK4.38430441
5MAP2K23.92839024
6EIF2AK33.65369433
7TRIB33.17422113
8PKN23.02017905
9EPHA22.63540782
10FRK2.22437297
11MAPKAPK32.01417615
12NEK114.7356841
13INSRR1.96839077
14ZAP701.95774952
15PIK3CG1.85074405
16NME11.83941805
17EPHB21.83723030
18CDK81.79269745
19MAP2K11.78885707
20IRAK31.65787459
21TAOK31.58386440
22MST1R1.49216467
23WNK41.42394163
24RPS6KB21.33911393
25MST41.29628494
26PDK21.29333169
27PAK21.28988425
28PDGFRB1.28972924
29NME21.20088479
30EEF2K1.19939904
31SCYL21.09060635
32PTK61.03265737
33PIK3CA1.01291008
34MAPK150.99425216
35STK390.99397261
36DYRK1A0.99133673
37LRRK20.97054935
38MAP2K60.96018101
39STK160.91848935
40MAP3K20.87154757
41FLT30.77715943
42LATS10.77096365
43ARAF0.74956167
44PRKCI0.74425686
45TTN0.69026163
46CAMKK10.67171471
47PINK10.64744916
48DAPK20.64279681
49KSR20.63907816
50PDPK10.63243857
51PDK30.60817297
52PDK40.60817297
53SIK10.59875887
54DMPK0.59447501
55MAP3K90.57740404
56FER0.55364696
57MET0.54093629
58RET0.51109704
59MAPK120.48882356
60PDK10.48120876
61IRAK10.47849124
62MYLK0.47214521
63MAP3K120.45718234
64GRK10.44449677
65RPS6KB10.43859015
66PRKCZ0.43588088
67MTOR0.43319249
68RIPK40.43296299
69TGFBR20.43083462
70ZAK0.42410750
71PASK0.41973892
72STK240.40089577
73MAP3K70.39880111
74PRKD30.37284267
75BMPR20.37142304
76IRAK40.37126362
77DYRK1B0.36255239
78IRAK20.35852794
79ERBB30.35296667
80OXSR10.32273545
81MAP2K30.30809807
82STK40.30579467
83MAP3K30.29551035
84TESK10.29303264
85STK38L0.29113626
86CDK190.28557782
87RPS6KA10.28470580
88CSNK1G10.28094595
89PRKCH0.27853191
90MAPKAPK50.27670096
91TBK10.27623202
92ADRBK10.27599778
93MAP2K70.26514789
94ABL20.26397652
95MAP3K80.26199524
96TAOK10.25046659
97PRKACB0.23995326
98EPHB10.23800772
99SGK2230.23623247
100SGK4940.23623247
101CAMKK20.22924330
102EIF2AK10.22373961
103NEK60.22181980
104MATK0.21570924
105PRKD10.21397895
106MAPK30.20825801
107PAK40.20816556
108DDR20.19938619
109CSNK1G30.19907624
110ABL10.19585566
111RIPK10.19422026
112LMTK20.18919998
113JAK20.18269694
114NUAK10.18212832
115PIM20.18051972
116MAP3K10.17902270
117PTK20.17901311
118PRKG20.17434358
119MAP3K100.16617668
120STK100.15970144
121IGF1R0.15708233
122PRKD20.15539443
123ILK0.15477165
124PRKCD0.14564846
125FYN0.13821543
126CDK90.13349724
127MAP2K40.12958623
128CSNK1A1L0.12135984
129TGFBR10.11654511
130EGFR0.11652480
131MAPK110.11419269
132BMX0.11247803
133TYRO30.11170635
134PRKAA20.10394091
135HIPK20.10094225
136CSK0.09779409
137PHKG20.09075715
138PHKG10.09075715
139TRPM70.08814258
140MELK0.07644230
141CSNK1E0.07105499
142CSNK1G20.05956793
143SRC0.05545935
144PRKCE0.05376207
145CDK30.04927171
146MAPK130.04624162
147CAMK2D0.04210095
148MAP3K40.03644365
149PRKCQ0.03164135
150GRK50.03154100

Predicted pathways (KEGG)

RankGene SetZ-score
1Pancreatic secretion_Homo sapiens_hsa049727.69128007
2Fat digestion and absorption_Homo sapiens_hsa049756.08497952
3Protein digestion and absorption_Homo sapiens_hsa049744.83008674
4Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006034.60665576
5Glycerolipid metabolism_Homo sapiens_hsa005613.06225414
6Protein export_Homo sapiens_hsa030602.99933274
7Folate biosynthesis_Homo sapiens_hsa007902.76638744
8Maturity onset diabetes of the young_Homo sapiens_hsa049502.44593551
9Cyanoamino acid metabolism_Homo sapiens_hsa004602.22419448
10Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.21439104
11Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.17430997
12Vitamin digestion and absorption_Homo sapiens_hsa049772.15853794
13Hepatitis C_Homo sapiens_hsa051602.02598120
14Tight junction_Homo sapiens_hsa045301.97116295
15Propanoate metabolism_Homo sapiens_hsa006401.95378709
16Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.93409366
17Glycosaminoglycan degradation_Homo sapiens_hsa005311.84685182
18Sulfur metabolism_Homo sapiens_hsa009201.78478656
19Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.67031425
20Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.54472884
21Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.53567572
22Steroid biosynthesis_Homo sapiens_hsa001001.51555645
23Leukocyte transendothelial migration_Homo sapiens_hsa046701.51163279
24Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.46432879
25alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.44880714
26Tyrosine metabolism_Homo sapiens_hsa003501.40950905
272-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.40290331
28Linoleic acid metabolism_Homo sapiens_hsa005911.37347844
29Steroid hormone biosynthesis_Homo sapiens_hsa001401.37192204
30Glutathione metabolism_Homo sapiens_hsa004801.33230364
31Chemical carcinogenesis_Homo sapiens_hsa052041.30707517
32Fatty acid biosynthesis_Homo sapiens_hsa000611.25008787
33Renin-angiotensin system_Homo sapiens_hsa046141.21403469
34Gastric acid secretion_Homo sapiens_hsa049711.13879502
35Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.13598599
36Arginine and proline metabolism_Homo sapiens_hsa003301.04704442
37Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.97194388
38Other glycan degradation_Homo sapiens_hsa005110.95427619
39Fatty acid degradation_Homo sapiens_hsa000710.95382354
40Biosynthesis of amino acids_Homo sapiens_hsa012300.92416024
41Starch and sucrose metabolism_Homo sapiens_hsa005000.89921409
42beta-Alanine metabolism_Homo sapiens_hsa004100.89833703
43Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.84780315
44Cysteine and methionine metabolism_Homo sapiens_hsa002700.84496245
45RNA polymerase_Homo sapiens_hsa030200.83095065
46Selenocompound metabolism_Homo sapiens_hsa004500.82828586
47Sulfur relay system_Homo sapiens_hsa041220.81698347
48Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.80908840
49N-Glycan biosynthesis_Homo sapiens_hsa005100.79686725
50Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.79176822
51Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.78419672
52PPAR signaling pathway_Homo sapiens_hsa033200.78346350
53Fatty acid elongation_Homo sapiens_hsa000620.77943048
54Pyruvate metabolism_Homo sapiens_hsa006200.76355473
55Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.75321390
56Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.73966021
57Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.73896620
58Taste transduction_Homo sapiens_hsa047420.73179411
59Vascular smooth muscle contraction_Homo sapiens_hsa042700.71635950
60Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.71597879
61Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.71419873
62cGMP-PKG signaling pathway_Homo sapiens_hsa040220.71289528
63Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.67270367
64Arachidonic acid metabolism_Homo sapiens_hsa005900.67019907
65Pyrimidine metabolism_Homo sapiens_hsa002400.66380845
66Influenza A_Homo sapiens_hsa051640.63972563
67Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.62650400
68Sphingolipid metabolism_Homo sapiens_hsa006000.61869121
69Purine metabolism_Homo sapiens_hsa002300.61833204
70Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.58424591
71Primary bile acid biosynthesis_Homo sapiens_hsa001200.58299742
72Fructose and mannose metabolism_Homo sapiens_hsa000510.53080491
73Ether lipid metabolism_Homo sapiens_hsa005650.52865224
74Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.52170121
75Carbon metabolism_Homo sapiens_hsa012000.51700402
76Carbohydrate digestion and absorption_Homo sapiens_hsa049730.48948947
77Notch signaling pathway_Homo sapiens_hsa043300.47121635
78Proteasome_Homo sapiens_hsa030500.47089773
79Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.45223551
80Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.43601420
81Vibrio cholerae infection_Homo sapiens_hsa051100.42564829
82p53 signaling pathway_Homo sapiens_hsa041150.41373923
83Drug metabolism - other enzymes_Homo sapiens_hsa009830.41368950
84Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.39736170
85Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.39172745
86Insulin secretion_Homo sapiens_hsa049110.38610394
87Arginine biosynthesis_Homo sapiens_hsa002200.38244583
88Alzheimers disease_Homo sapiens_hsa050100.37906455
89Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.37905758
90Legionellosis_Homo sapiens_hsa051340.36961749
91One carbon pool by folate_Homo sapiens_hsa006700.36792919
92Metabolic pathways_Homo sapiens_hsa011000.35929731
93Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.35852581
94Parkinsons disease_Homo sapiens_hsa050120.35850703
95Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.35554222
96Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.35526250
97Histidine metabolism_Homo sapiens_hsa003400.35415314
98Caffeine metabolism_Homo sapiens_hsa002320.33175858
99Oxidative phosphorylation_Homo sapiens_hsa001900.32487241
100Lysine degradation_Homo sapiens_hsa003100.32414476
101Collecting duct acid secretion_Homo sapiens_hsa049660.32348443
102Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.31673702
103Tryptophan metabolism_Homo sapiens_hsa003800.30319915
104Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.30030911
105Fatty acid metabolism_Homo sapiens_hsa012120.27104727
106Shigellosis_Homo sapiens_hsa051310.27064407
107Lysosome_Homo sapiens_hsa041420.24342985
108Phenylalanine metabolism_Homo sapiens_hsa003600.23462393
109Ovarian steroidogenesis_Homo sapiens_hsa049130.23266878
110Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.23077748
111Glycerophospholipid metabolism_Homo sapiens_hsa005640.20278745
112Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.19760378
113Pentose and glucuronate interconversions_Homo sapiens_hsa000400.19296124
114Mineral absorption_Homo sapiens_hsa049780.17057792
115Galactose metabolism_Homo sapiens_hsa000520.14363213
116Thyroid hormone synthesis_Homo sapiens_hsa049180.14133867
117Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.13946836
118Peroxisome_Homo sapiens_hsa041460.13288493
119VEGF signaling pathway_Homo sapiens_hsa043700.12652582
120Calcium signaling pathway_Homo sapiens_hsa040200.10836001
121Salivary secretion_Homo sapiens_hsa049700.10681322
122Endometrial cancer_Homo sapiens_hsa052130.10201998
123SNARE interactions in vesicular transport_Homo sapiens_hsa041300.10146482
124Regulation of autophagy_Homo sapiens_hsa041400.08565772
125Nitrogen metabolism_Homo sapiens_hsa009100.08513502
126Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.07828672
127Bile secretion_Homo sapiens_hsa049760.07132269
128Butanoate metabolism_Homo sapiens_hsa006500.05508410
129Toxoplasmosis_Homo sapiens_hsa051450.05131239
130Pentose phosphate pathway_Homo sapiens_hsa000300.04317016
131Retinol metabolism_Homo sapiens_hsa008300.03304292
132Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.02611638

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