TFAMP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of pigment cell differentiation (GO:0050932)8.12074849
2positive regulation of developmental pigmentation (GO:0048087)7.84487353
3regulation of odontogenesis of dentin-containing tooth (GO:0042487)7.56812011
4regulation of meiosis I (GO:0060631)7.55979970
5DNA methylation involved in gamete generation (GO:0043046)7.46310046
6protein-chromophore linkage (GO:0018298)7.34286089
7lipopolysaccharide biosynthetic process (GO:0009103)6.82517985
8lipopolysaccharide metabolic process (GO:0008653)6.14042182
9sulfate transmembrane transport (GO:1902358)6.02055282
10negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)5.59848276
11regulation of protein glycosylation (GO:0060049)5.56184731
12piRNA metabolic process (GO:0034587)5.39907340
13paraxial mesoderm development (GO:0048339)5.20402788
14sulfate transport (GO:0008272)5.18967869
15meiotic chromosome segregation (GO:0045132)5.11627852
16regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)5.01798871
17negative regulation of glycoprotein biosynthetic process (GO:0010561)4.96391934
18negative regulation of cell cycle G2/M phase transition (GO:1902750)4.92788030
19heme transport (GO:0015886)4.89466237
20germinal center formation (GO:0002467)4.75409219
21regulation of rhodopsin mediated signaling pathway (GO:0022400)4.58653500
22gamma-aminobutyric acid signaling pathway (GO:0007214)4.53510090
23positive regulation of dendritic spine morphogenesis (GO:0061003)4.40641201
24vitamin transmembrane transport (GO:0035461)4.37152477
25sympathetic nervous system development (GO:0048485)4.34430981
26positive regulation of meiosis (GO:0045836)4.24104572
27rhodopsin mediated signaling pathway (GO:0016056)4.17284397
28tyrosine metabolic process (GO:0006570)4.16348887
29L-phenylalanine catabolic process (GO:0006559)4.09407785
30erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.09407785
31response to nitrosative stress (GO:0051409)4.02453264
32ribonucleoprotein complex disassembly (GO:0032988)3.99346585
33regulation of developmental pigmentation (GO:0048070)3.95383883
34positive regulation of meiotic cell cycle (GO:0051446)3.92665873
35flavonoid metabolic process (GO:0009812)3.90072597
36notochord development (GO:0030903)3.88676996
37ionotropic glutamate receptor signaling pathway (GO:0035235)3.71795253
38DNA deamination (GO:0045006)3.67828292
39cellular response to reactive nitrogen species (GO:1902170)3.65509987
40regulation of nuclear cell cycle DNA replication (GO:0033262)3.64981876
41SMAD protein complex assembly (GO:0007183)3.64855981
42serotonin receptor signaling pathway (GO:0007210)3.56894422
43reciprocal DNA recombination (GO:0035825)3.55660176
44reciprocal meiotic recombination (GO:0007131)3.55660176
45iron coordination entity transport (GO:1901678)3.55485600
46negative regulation of glycoprotein metabolic process (GO:1903019)3.54454099
47tachykinin receptor signaling pathway (GO:0007217)3.50460042
48centriole replication (GO:0007099)3.47323085
49regulation of odontogenesis (GO:0042481)3.37735571
50negative regulation of stem cell proliferation (GO:2000647)3.31191207
51erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.30426970
52L-phenylalanine metabolic process (GO:0006558)3.30426970
53cellular response to gamma radiation (GO:0071480)3.30111090
54heart valve formation (GO:0003188)3.28270607
55regulation of transforming growth factor beta2 production (GO:0032909)3.26526992
56glutamate receptor signaling pathway (GO:0007215)3.25941128
57pantothenate metabolic process (GO:0015939)3.23446440
58protein kinase C-activating G-protein coupled receptor signaling pathway (GO:0007205)3.23099410
59postsynaptic membrane organization (GO:0001941)3.18406627
60sulfur compound transport (GO:0072348)3.11461388
61organelle disassembly (GO:1903008)3.09291991
62glycerol metabolic process (GO:0006071)3.08153870
63regulation of keratinocyte proliferation (GO:0010837)3.06992954
64regulation of interleukin-5 production (GO:0032674)3.06519897
65lysine catabolic process (GO:0006554)3.00099162
66lysine metabolic process (GO:0006553)3.00099162
67nodal signaling pathway (GO:0038092)2.99757120
68epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.99219430
69regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.98010834
70negative regulation of cell-matrix adhesion (GO:0001953)2.90350075
71regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.88655128
72cerebral cortex radially oriented cell migration (GO:0021799)2.85926449
73activation of protein kinase A activity (GO:0034199)2.85818184
74G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.83495405
75fucose catabolic process (GO:0019317)2.82083064
76L-fucose metabolic process (GO:0042354)2.82083064
77L-fucose catabolic process (GO:0042355)2.82083064
78aromatic amino acid family catabolic process (GO:0009074)2.80822863
79synaptic transmission, glutamatergic (GO:0035249)2.80733868
80cell migration in hindbrain (GO:0021535)2.78412870
81response to mercury ion (GO:0046689)2.78224171
82negative regulation of mast cell activation (GO:0033004)2.77192707
83cellular response to nitric oxide (GO:0071732)2.75547297
84negative regulation of norepinephrine secretion (GO:0010700)2.72173792
85aspartate family amino acid catabolic process (GO:0009068)2.71104858
86regulation of uterine smooth muscle contraction (GO:0070472)2.69225739
87somite rostral/caudal axis specification (GO:0032525)2.68154189
88negative regulation of DNA-dependent DNA replication (GO:2000104)2.67780851
89regulation of nephron tubule epithelial cell differentiation (GO:0072182)2.64233865
90alditol metabolic process (GO:0019400)2.62760507
91positive regulation of amine transport (GO:0051954)2.61704894
92chemosensory behavior (GO:0007635)2.61587569
93adaptation of signaling pathway (GO:0023058)2.61435146
94cellular response to sterol (GO:0036315)2.59789189
95positive regulation of SMAD protein import into nucleus (GO:0060391)2.59341087
96negative regulation of neural precursor cell proliferation (GO:2000178)2.58841432
97response to epinephrine (GO:0071871)2.56659337
98sphingosine metabolic process (GO:0006670)13.0002110
99diol metabolic process (GO:0034311)11.8510367
100sphingoid metabolic process (GO:0046519)11.2916814

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IGF1R_20145208_ChIP-Seq_DFB_Human4.88999588
2EZH2_22144423_ChIP-Seq_EOC_Human4.35626480
3AR_21572438_ChIP-Seq_LNCaP_Human3.97513742
4GBX2_23144817_ChIP-Seq_PC3_Human3.24498395
5CTBP2_25329375_ChIP-Seq_LNCAP_Human3.09597713
6GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.65920170
7CTBP1_25329375_ChIP-Seq_LNCAP_Human2.36482860
8P300_19829295_ChIP-Seq_ESCs_Human2.32842075
9ZNF274_21170338_ChIP-Seq_K562_Hela2.27104648
10ZFP57_27257070_Chip-Seq_ESCs_Mouse2.26432630
11RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.19269813
12TAF15_26573619_Chip-Seq_HEK293_Human2.08354236
13CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.02966749
14NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.97769071
15FLI1_27457419_Chip-Seq_LIVER_Mouse1.94304310
16FUS_26573619_Chip-Seq_HEK293_Human1.91308048
17CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.87083728
18TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.86338916
19POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.86338916
20AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.85626564
21ER_23166858_ChIP-Seq_MCF-7_Human1.84743295
22PIAS1_25552417_ChIP-Seq_VCAP_Human1.81634163
23POU3F2_20337985_ChIP-ChIP_501MEL_Human1.74073837
24SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.71197813
25TP63_19390658_ChIP-ChIP_HaCaT_Human1.71190507
26PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.65092886
27PCGF2_27294783_Chip-Seq_ESCs_Mouse1.63267485
28BMI1_23680149_ChIP-Seq_NPCS_Mouse1.59177608
29TOP2B_26459242_ChIP-Seq_MCF-7_Human1.55082350
30TCF4_23295773_ChIP-Seq_U87_Human1.54101688
31SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.51699317
32* STAT3_23295773_ChIP-Seq_U87_Human1.50937108
33SMAD4_21799915_ChIP-Seq_A2780_Human1.49646434
34SOX2_19829295_ChIP-Seq_ESCs_Human1.48206805
35NANOG_19829295_ChIP-Seq_ESCs_Human1.48206805
36SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.46693367
37EZH2_27294783_Chip-Seq_NPCs_Mouse1.45705564
38NOTCH1_21737748_ChIP-Seq_TLL_Human1.45458438
39NR3C1_21868756_ChIP-Seq_MCF10A_Human1.43985697
40SUZ12_27294783_Chip-Seq_NPCs_Mouse1.43400505
41GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.43363058
42PRDM14_20953172_ChIP-Seq_ESCs_Human1.43274387
43STAT6_21828071_ChIP-Seq_BEAS2B_Human1.43046913
44CBP_20019798_ChIP-Seq_JUKART_Human1.41347387
45IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.41347387
46FLI1_21867929_ChIP-Seq_TH2_Mouse1.40845342
47NFE2_27457419_Chip-Seq_LIVER_Mouse1.40211787
48REST_21632747_ChIP-Seq_MESCs_Mouse1.39918085
49AR_25329375_ChIP-Seq_VCAP_Human1.39467429
50VDR_22108803_ChIP-Seq_LS180_Human1.39371473
51CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.35163186
52STAT3_18555785_ChIP-Seq_MESCs_Mouse1.32695743
53PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.30719360
54TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.30563458
55TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.30341036
56UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.30205499
57BP1_19119308_ChIP-ChIP_Hs578T_Human1.29178075
58PCGF2_27294783_Chip-Seq_NPCs_Mouse1.28348060
59VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.26835349
60SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.26803790
61OCT4_21477851_ChIP-Seq_ESCs_Mouse1.26599174
62EZH2_27294783_Chip-Seq_ESCs_Mouse1.24471443
63SMAD3_21741376_ChIP-Seq_EPCs_Human1.24357264
64KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.23326697
65SMAD4_21741376_ChIP-Seq_EPCs_Human1.23042443
66EZH2_27304074_Chip-Seq_ESCs_Mouse1.22454841
67NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.20837237
68CRX_20693478_ChIP-Seq_RETINA_Mouse1.20521607
69SALL1_21062744_ChIP-ChIP_HESCs_Human1.19234053
70MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.17873799
71SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.16477790
72GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.15924691
73TP53_18474530_ChIP-ChIP_U2OS_Human1.15908696
74SMAD3_21741376_ChIP-Seq_ESCs_Human1.15106478
75TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.15087107
76KLF5_20875108_ChIP-Seq_MESCs_Mouse1.12960597
77EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.11710355
78EWS_26573619_Chip-Seq_HEK293_Human1.11427746
79JARID2_20075857_ChIP-Seq_MESCs_Mouse1.11421003
80RUNX2_22187159_ChIP-Seq_PCA_Human1.11400648
81EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.11279738
82AR_19668381_ChIP-Seq_PC3_Human1.10806510
83TCF4_22108803_ChIP-Seq_LS180_Human1.09842534
84E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.09639623
85TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.09179575
86EGR1_19032775_ChIP-ChIP_M12_Human1.08002500
87JARID2_20064375_ChIP-Seq_MESCs_Mouse1.07968563
88HOXB7_26014856_ChIP-Seq_BT474_Human1.07612354
89SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.07021048
90TBX3_20139965_ChIP-Seq_ESCs_Mouse1.06100950
91EED_16625203_ChIP-ChIP_MESCs_Mouse1.05281961
92TBX3_20139965_ChIP-Seq_MESCs_Mouse1.04798171
93SMAD3_21741376_ChIP-Seq_HESCs_Human1.04539571
94CJUN_26792858_Chip-Seq_BT549_Human1.03995422
95GATA3_21878914_ChIP-Seq_MCF-7_Human1.02378791
96SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.02078029
97RNF2_27304074_Chip-Seq_ESCs_Mouse1.01509812
98CTNNB1_20460455_ChIP-Seq_HCT116_Human1.00940538
99SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.00604043
100LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.99024259

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis8.09250991
2MP0003136_yellow_coat_color6.91347942
3MP0005171_absent_coat_pigmentation6.36027430
4MP0002653_abnormal_ependyma_morphology5.33575857
5MP0000569_abnormal_digit_pigmentation4.77693982
6MP0003045_fibrosis4.75255267
7MP0003890_abnormal_embryonic-extraembry3.62424404
8MP0003646_muscle_fatigue3.36738785
9MP0003879_abnormal_hair_cell3.13760016
10MP0005670_abnormal_white_adipose3.05592084
11MP0004381_abnormal_hair_follicle2.92212367
12MP0002168_other_aberrant_phenotype2.16600202
13MP0002735_abnormal_chemical_nociception2.12499669
14MP0005075_abnormal_melanosome_morpholog2.04080775
15MP0002138_abnormal_hepatobiliary_system1.99158586
16MP0005085_abnormal_gallbladder_physiolo1.85934380
17MP0003137_abnormal_impulse_conducting1.64158432
18MP0005174_abnormal_tail_pigmentation1.60964278
19MP0003195_calcinosis1.60797068
20MP0001486_abnormal_startle_reflex1.54904982
21MP0002095_abnormal_skin_pigmentation1.50724269
22MP0001501_abnormal_sleep_pattern1.49826832
23MP0009046_muscle_twitch1.47354403
24MP0000749_muscle_degeneration1.45489530
25MP0001984_abnormal_olfaction1.40988998
26MP0002938_white_spotting1.34089930
27MP0003705_abnormal_hypodermis_morpholog1.28487414
28MP0005395_other_phenotype1.25874931
29MP0002075_abnormal_coat/hair_pigmentati1.25853755
30MP0004859_abnormal_synaptic_plasticity1.23866230
31MP0004233_abnormal_muscle_weight1.20694878
32MP0001529_abnormal_vocalization1.19816443
33MP0002160_abnormal_reproductive_system1.17163446
34MP0008872_abnormal_physiological_respon1.16635514
35MP0000015_abnormal_ear_pigmentation1.12134958
36MP0002272_abnormal_nervous_system1.09172865
37MP0002733_abnormal_thermal_nociception1.04538947
38MP0003635_abnormal_synaptic_transmissio1.04159987
39MP0004147_increased_porphyrin_level1.03280227
40MP0001970_abnormal_pain_threshold1.02382078
41MP0010352_gastrointestinal_tract_polyps1.00985770
42MP0003183_abnormal_peptide_metabolism0.96779632
43MP0009745_abnormal_behavioral_response0.92626382
44MP0001440_abnormal_grooming_behavior0.92521732
45MP0002572_abnormal_emotion/affect_behav0.88226908
46MP0004043_abnormal_pH_regulation0.86510176
47MP0005551_abnormal_eye_electrophysiolog0.86194260
48MP0002971_abnormal_brown_adipose0.80206557
49MP0004270_analgesia0.80183773
50MP0005365_abnormal_bile_salt0.79816923
51MP0001186_pigmentation_phenotype0.78517004
52MP0002064_seizures0.78147440
53MP0008569_lethality_at_weaning0.77614160
54MP0004924_abnormal_behavior0.76264353
55MP0005386_behavior/neurological_phenoty0.76264353
56MP0000778_abnormal_nervous_system0.70530485
57MP0002269_muscular_atrophy0.68760089
58MP0003632_abnormal_nervous_system0.67744744
59MP0001968_abnormal_touch/_nociception0.67419868
60MP0002067_abnormal_sensory_capabilities0.66053833
61MP0002063_abnormal_learning/memory/cond0.65962885
62MP0000534_abnormal_ureter_morphology0.65905688
63MP0002229_neurodegeneration0.65464001
64MP0003329_amyloid_beta_deposits0.65060480
65MP0008770_decreased_survivor_rate0.63738184
66MP0005330_cardiomyopathy0.57074235
67MP0005410_abnormal_fertilization0.55998215
68MP0003787_abnormal_imprinting0.54730495
69MP0000427_abnormal_hair_cycle0.53807689
70MP0002277_abnormal_respiratory_mucosa0.53755377
71MP0008877_abnormal_DNA_methylation0.52979000
72MP0002734_abnormal_mechanical_nocicepti0.52272466
73MP0005389_reproductive_system_phenotype0.52061151
74MP0002876_abnormal_thyroid_physiology0.51986360
75MP0001324_abnormal_eye_pigmentation0.51678037
76MP0003252_abnormal_bile_duct0.49281444
77MP0002102_abnormal_ear_morphology0.47901872
78MP0003631_nervous_system_phenotype0.47818415
79MP0002882_abnormal_neuron_morphology0.47764884
80MP0002557_abnormal_social/conspecific_i0.46722776
81MP0000371_diluted_coat_color0.45429846
82MP0006072_abnormal_retinal_apoptosis0.44951512
83MP0002254_reproductive_system_inflammat0.44132396
84MP0004142_abnormal_muscle_tone0.43329307
85MP0000026_abnormal_inner_ear0.43282980
86MP0003698_abnormal_male_reproductive0.43148202
87MP0002736_abnormal_nociception_after0.42932147
88MP0008789_abnormal_olfactory_epithelium0.42861744
89MP0009115_abnormal_fat_cell0.39981262
90MP0002752_abnormal_somatic_nervous0.39892571
91MP0004484_altered_response_of0.39866187
92MP0005620_abnormal_muscle_contractility0.39466519
93MP0003959_abnormal_lean_body0.39426657
94MP0002928_abnormal_bile_duct0.39215591
95MP0001963_abnormal_hearing_physiology0.39128905
96MP0002751_abnormal_autonomic_nervous0.38306673
97MP0003937_abnormal_limbs/digits/tail_de0.36796735
98MP0005499_abnormal_olfactory_system0.36418394
99MP0005394_taste/olfaction_phenotype0.36418394
100MP0005195_abnormal_posterior_eye0.35869058

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)8.37409320
2Amelogenesis imperfecta (HP:0000705)7.46059939
3Parakeratosis (HP:0001036)6.15831997
4Acanthocytosis (HP:0001927)5.75795373
5Congenital nonbullous ichthyosiform erythroderma (HP:0007479)5.50296483
6Pancreatic cysts (HP:0001737)4.68012411
7Dialeptic seizures (HP:0011146)4.67127534
8Aplasia/Hypoplasia of the uvula (HP:0010293)4.27856152
9Focal seizures (HP:0007359)3.84731767
10Colon cancer (HP:0003003)3.72291668
11Hematochezia (HP:0002573)3.57782652
12Aplastic anemia (HP:0001915)3.57131865
13Chromosomal breakage induced by crosslinking agents (HP:0003221)3.50331627
14Proximal amyotrophy (HP:0007126)3.47090946
15Spontaneous hematomas (HP:0007420)3.32916771
16Abnormality of the renal medulla (HP:0100957)3.25017908
17Nephronophthisis (HP:0000090)3.23577174
18Rectal prolapse (HP:0002035)3.23112728
19Erythroderma (HP:0001019)3.18650166
20Difficulty walking (HP:0002355)3.10367000
21Congenital stationary night blindness (HP:0007642)3.01440711
22Abnormality of the renal cortex (HP:0011035)3.00142332
23Chromsome breakage (HP:0040012)2.98521888
24Pancreatic fibrosis (HP:0100732)2.94537698
25Esophageal varix (HP:0002040)2.91473417
26Congenital ichthyosiform erythroderma (HP:0007431)2.91297658
27Potter facies (HP:0002009)2.88470261
28Facial shape deformation (HP:0011334)2.88470261
29Overlapping toe (HP:0001845)2.87954983
30Febrile seizures (HP:0002373)2.83463382
31Poikilocytosis (HP:0004447)2.68249609
32Ulnar claw (HP:0001178)2.66929649
33Cystic liver disease (HP:0006706)2.63543566
34Global brain atrophy (HP:0002283)2.60773185
35Synostosis of carpal bones (HP:0005048)2.58975841
36Pendular nystagmus (HP:0012043)2.58324802
37Vertebral arch anomaly (HP:0008438)2.50450423
38Abnormality of the vocal cords (HP:0008777)2.49645756
39Duplicated collecting system (HP:0000081)2.49042277
40Prolonged partial thromboplastin time (HP:0003645)2.48869242
41Bile duct proliferation (HP:0001408)2.46465674
42Abnormal biliary tract physiology (HP:0012439)2.46465674
43Abnormality of aromatic amino acid family metabolism (HP:0004338)2.44483061
44Abnormality of the renal collecting system (HP:0004742)2.42573063
45Autoimmune hemolytic anemia (HP:0001890)2.41554635
46Scapular winging (HP:0003691)2.41465980
47Joint hemorrhage (HP:0005261)2.40543914
48True hermaphroditism (HP:0010459)2.31700211
49Increased neuronal autofluorescent lipopigment (HP:0002074)2.31273065
50Inability to walk (HP:0002540)2.29385345
51Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.26379321
52Broad-based gait (HP:0002136)2.22920555
53Progressive inability to walk (HP:0002505)2.20786857
54Tubulointerstitial fibrosis (HP:0005576)2.16491579
55Cerebellar dysplasia (HP:0007033)2.16434494
56Molar tooth sign on MRI (HP:0002419)2.15890824
57Abnormality of midbrain morphology (HP:0002418)2.15890824
58Abnormality of the intrinsic pathway (HP:0010989)2.15755608
59Enlarged kidneys (HP:0000105)2.11712137
60Abnormality of macular pigmentation (HP:0008002)2.11442839
61Bilateral sensorineural hearing impairment (HP:0008619)2.10948677
62Conical tooth (HP:0000698)2.10179482
63Atonic seizures (HP:0010819)2.10149988
64Neoplasm of the small intestine (HP:0100833)2.07688277
65Conjunctival telangiectasia (HP:0000524)2.03190143
66Absence seizures (HP:0002121)2.01551614
67Volvulus (HP:0002580)1.98761605
68Tarsal synostosis (HP:0008368)1.97377129
69Broad ribs (HP:0000885)1.97080638
70Tubular atrophy (HP:0000092)1.94313313
71Abnormality of monocarboxylic acid metabolism (HP:0010996)1.92568165
72Aplasia/Hypoplasia of the spleen (HP:0010451)1.89911863
73Oligodontia (HP:0000677)1.89350096
74Reticulocytopenia (HP:0001896)1.87326779
75Asplenia (HP:0001746)1.87161389
76Synostosis involving bones of the lower limbs (HP:0009138)1.86569756
77Synostosis involving bones of the feet (HP:0009140)1.86569756
78Meningioma (HP:0002858)1.84846119
79Portal hypertension (HP:0001409)1.84427288
80Albinism (HP:0001022)1.84067180
81Hypokalemia (HP:0002900)1.83565292
82Drooling (HP:0002307)1.83039753
83Absent speech (HP:0001344)1.81007566
84Radial bowing (HP:0002986)1.79944203
85Vacuolated lymphocytes (HP:0001922)1.79734073
86Hypoalbuminemia (HP:0003073)1.78857583
87Abnormal albumin level (HP:0012116)1.78857583
88Retinitis pigmentosa (HP:0000510)1.77870123
89Ulnar bowing (HP:0003031)1.77349419
90Increased cerebral lipofuscin (HP:0011813)1.74719495
91Impaired smooth pursuit (HP:0007772)1.74652343
92Decreased circulating renin level (HP:0003351)1.73951511
93Severe visual impairment (HP:0001141)1.73759415
94Clubbing of toes (HP:0100760)1.72593853
95Type II lissencephaly (HP:0007260)1.71956698
96Congenital hepatic fibrosis (HP:0002612)1.71776484
97Excessive salivation (HP:0003781)1.67344966
98Clumsiness (HP:0002312)1.67266651
99Hyperalaninemia (HP:0003348)1.66717553
100Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.66717553

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LATS19.73612030
2STK38L6.57104663
3LATS25.72024116
4PINK13.40412777
5FRK2.98740821
6PRKD32.79261029
7NLK2.70821444
8MAP3K42.61635818
9STK382.48971757
10ZAK2.46725886
11MAP3K62.35397927
12MAP2K71.95207938
13ACVR1B1.86473074
14MAP2K21.85476887
15STK31.74945275
16GRK11.52609467
17MAP3K21.35796059
18ADRBK21.34829086
19MELK1.20428011
20BMPR1B1.16854973
21NEK21.12320529
22PIK3CG1.11775185
23CASK1.08510461
24MAP2K41.05011114
25KSR20.98923191
26CSNK1A1L0.93322584
27CCNB10.90265503
28EIF2AK30.90158627
29WNK40.89335031
30MARK10.79455753
31DAPK20.78352985
32ADRBK10.77320218
33PRKAA20.68604052
34GRK70.67183473
35IRAK30.60404969
36RET0.54345134
37PDPK10.54307745
38MAP3K50.53857835
39SIK20.49919676
40NTRK30.44473947
41CSNK1G10.44462991
42STK390.44005459
43TGFBR10.41975946
44FER0.35976448
45DYRK1A0.35706715
46STK110.35122691
47MAPK70.34054348
48PRKD10.33901038
49CDK30.33721713
50GRK50.33512443
51MAP2K60.33362440
52PHKG20.31640038
53PHKG10.31640038
54TGFBR20.31433442
55SCYL20.31340877
56MAPK130.30239678
57MAP2K10.30230881
58WNK30.30220985
59PBK0.30123381
60DYRK20.30061799
61FGFR30.29324667
62MAP3K10.27974683
63OXSR10.26393197
64TEC0.26237925
65TAOK10.26188655
66CAMK2B0.25214771
67PRKCG0.23655867
68CDK50.22322605
69PRKCE0.21871067
70PIM10.20401873
71PRKG20.17691183
72TAF10.16337698
73TAOK30.15931322
74CSNK1A10.15142204
75PRKACA0.13696938
76CAMK2A0.13695328
77NUAK10.13242320
78MAPK30.13042110
79MOS0.12994771
80CSNK1D0.12960839
81PRKACB0.12775272
82MAPK80.11657203
83GSK3B0.11021708
84PIK3CA0.10858729
85ABL10.10355188
86PLK10.10311855
87TNK20.09770977
88TAOK20.09053426
89TRIM280.09011580
90MINK10.08722133
91PLK40.07816869
92CDK190.07731290
93MAP4K20.06109846
94TXK0.04225890
95SGK10.03976831
96AKT20.03492272
97MAPK10.03239350
98PRKCB0.02221522
99CSNK1G20.02097810
100MAPK40.01904267

Predicted pathways (KEGG)

RankGene SetZ-score
1Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004006.40382394
2Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001304.93102010
3Phototransduction_Homo sapiens_hsa047444.65663705
4Sphingolipid metabolism_Homo sapiens_hsa006003.65132643
5Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006013.44702188
6Nicotine addiction_Homo sapiens_hsa050333.31088545
7Taste transduction_Homo sapiens_hsa047423.11180513
8Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.90136312
9Dorso-ventral axis formation_Homo sapiens_hsa043202.28748848
10Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.23084300
11Morphine addiction_Homo sapiens_hsa050322.12132830
12GABAergic synapse_Homo sapiens_hsa047271.92344008
13Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.83089354
14Glutamatergic synapse_Homo sapiens_hsa047241.72297047
15Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.58380803
16Phenylalanine metabolism_Homo sapiens_hsa003601.24957411
17Butanoate metabolism_Homo sapiens_hsa006501.24190633
18Serotonergic synapse_Homo sapiens_hsa047261.21156971
19Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.20719852
20Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.20537520
21Calcium signaling pathway_Homo sapiens_hsa040201.17671824
22Circadian entrainment_Homo sapiens_hsa047131.15078906
23Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.11668584
24Histidine metabolism_Homo sapiens_hsa003401.10988886
25alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.07108761
26N-Glycan biosynthesis_Homo sapiens_hsa005101.05642897
27Maturity onset diabetes of the young_Homo sapiens_hsa049501.02317501
28Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.99133253
29Nitrogen metabolism_Homo sapiens_hsa009100.98969418
30Ovarian steroidogenesis_Homo sapiens_hsa049130.97808576
31Dilated cardiomyopathy_Homo sapiens_hsa054140.97577275
32Salivary secretion_Homo sapiens_hsa049700.96856434
33Tryptophan metabolism_Homo sapiens_hsa003800.93939515
34Sphingolipid signaling pathway_Homo sapiens_hsa040710.86439739
35Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.85206514
36Olfactory transduction_Homo sapiens_hsa047400.83772684
37Bile secretion_Homo sapiens_hsa049760.83731132
38Glycerolipid metabolism_Homo sapiens_hsa005610.83355852
39Long-term depression_Homo sapiens_hsa047300.79063227
40Vitamin digestion and absorption_Homo sapiens_hsa049770.78795651
41Basal transcription factors_Homo sapiens_hsa030220.76201915
42Linoleic acid metabolism_Homo sapiens_hsa005910.74330774
43Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.72878594
44Cysteine and methionine metabolism_Homo sapiens_hsa002700.70499622
45Steroid hormone biosynthesis_Homo sapiens_hsa001400.66475235
46cAMP signaling pathway_Homo sapiens_hsa040240.65996428
47Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.65859427
48ABC transporters_Homo sapiens_hsa020100.65528209
49Collecting duct acid secretion_Homo sapiens_hsa049660.65491676
50One carbon pool by folate_Homo sapiens_hsa006700.61478075
51Chemical carcinogenesis_Homo sapiens_hsa052040.60794485
52Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.60673076
53Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.60497407
54Viral myocarditis_Homo sapiens_hsa054160.60483423
55cGMP-PKG signaling pathway_Homo sapiens_hsa040220.58503071
56Gap junction_Homo sapiens_hsa045400.58411717
57VEGF signaling pathway_Homo sapiens_hsa043700.53866513
58Aldosterone synthesis and secretion_Homo sapiens_hsa049250.51907595
59TGF-beta signaling pathway_Homo sapiens_hsa043500.50495141
60Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.48339120
61Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.48172594
62Ether lipid metabolism_Homo sapiens_hsa005650.47821672
63Fatty acid degradation_Homo sapiens_hsa000710.46917269
64Tyrosine metabolism_Homo sapiens_hsa003500.44881592
65beta-Alanine metabolism_Homo sapiens_hsa004100.44308122
66Gastric acid secretion_Homo sapiens_hsa049710.44145144
67Platelet activation_Homo sapiens_hsa046110.42483076
68Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.42315938
69GnRH signaling pathway_Homo sapiens_hsa049120.40592760
70Vascular smooth muscle contraction_Homo sapiens_hsa042700.40330516
71Thyroid hormone synthesis_Homo sapiens_hsa049180.37714065
72NOD-like receptor signaling pathway_Homo sapiens_hsa046210.37337331
73Colorectal cancer_Homo sapiens_hsa052100.36002008
74Cholinergic synapse_Homo sapiens_hsa047250.35787745
75Insulin secretion_Homo sapiens_hsa049110.34248378
76Arachidonic acid metabolism_Homo sapiens_hsa005900.33453632
77Lysine degradation_Homo sapiens_hsa003100.33120519
78Fanconi anemia pathway_Homo sapiens_hsa034600.32930506
79Tuberculosis_Homo sapiens_hsa051520.32031650
80Dopaminergic synapse_Homo sapiens_hsa047280.31595019
81Retinol metabolism_Homo sapiens_hsa008300.31129343
82Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.30857327
83Renin secretion_Homo sapiens_hsa049240.30561192
84Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.28713036
85Oxytocin signaling pathway_Homo sapiens_hsa049210.28172314
86ECM-receptor interaction_Homo sapiens_hsa045120.26563717
87Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.26334716
88Phospholipase D signaling pathway_Homo sapiens_hsa040720.26072403
89Complement and coagulation cascades_Homo sapiens_hsa046100.25513623
90Type II diabetes mellitus_Homo sapiens_hsa049300.24874041
91Fatty acid biosynthesis_Homo sapiens_hsa000610.24364745
92Longevity regulating pathway - mammal_Homo sapiens_hsa042110.24098793
93Long-term potentiation_Homo sapiens_hsa047200.23722133
94Oocyte meiosis_Homo sapiens_hsa041140.23403227
95Adherens junction_Homo sapiens_hsa045200.20410460
96Hippo signaling pathway_Homo sapiens_hsa043900.19793440
97Adipocytokine signaling pathway_Homo sapiens_hsa049200.18570551
98Pyruvate metabolism_Homo sapiens_hsa006200.17157707
99Estrogen signaling pathway_Homo sapiens_hsa049150.16080439
100Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.15879804

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