TEX40

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1epithelial cilium movement (GO:0003351)9.66406469
2reproduction (GO:0000003)9.50351597
3spermatid development (GO:0007286)9.32051146
4motile cilium assembly (GO:0044458)9.02880719
5piRNA metabolic process (GO:0034587)8.95518495
6regulation of oxidative stress-induced neuron death (GO:1903203)8.47388847
7cilium movement (GO:0003341)8.23190370
8synaptonemal complex organization (GO:0070193)8.19771284
9synaptonemal complex assembly (GO:0007130)8.06820862
10epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)7.91501317
11regulation of cilium movement (GO:0003352)7.77758104
12nucleosome disassembly (GO:0006337)7.57010853
13protein-DNA complex disassembly (GO:0032986)7.57010853
14regulation of oxidative phosphorylation (GO:0002082)7.56090242
15* male meiosis (GO:0007140)7.48841086
16single fertilization (GO:0007338)7.35461681
17relaxation of smooth muscle (GO:0044557)7.28597446
18sperm capacitation (GO:0048240)7.19016193
19potassium ion export (GO:0071435)6.92262389
20polyamine biosynthetic process (GO:0006596)6.40000167
21negative regulation of hydrogen peroxide-induced cell death (GO:1903206)6.38584917
22negative regulation of inclusion body assembly (GO:0090084)6.25791074
23fertilization (GO:0009566)6.24544398
24Leydig cell differentiation (GO:0033327)6.07968205
25cGMP-mediated signaling (GO:0019934)6.06409196
26* spermatogenesis (GO:0007283)6.00086729
27activation of protein kinase B activity (GO:0032148)5.98482691
28* male gamete generation (GO:0048232)5.98002346
29negative regulation of response to reactive oxygen species (GO:1901032)5.81888087
30DNA methylation involved in gamete generation (GO:0043046)5.79346364
31male sex determination (GO:0030238)5.79144380
32regulation of hydrogen peroxide-induced cell death (GO:1903205)5.78087632
33chromosome organization involved in meiosis (GO:0070192)5.67419281
34* gamete generation (GO:0007276)5.49617144
35microtubule depolymerization (GO:0007019)5.48928014
36male meiosis I (GO:0007141)5.46263376
37spermatid nucleus differentiation (GO:0007289)5.46156267
38organic cation transport (GO:0015695)5.44691235
39cellular process involved in reproduction in multicellular organism (GO:0022412)5.31901919
40germ cell development (GO:0007281)5.29302957
41regulation of inclusion body assembly (GO:0090083)5.26482516
42TOR signaling (GO:0031929)5.25369621
43regulation of autophagic vacuole assembly (GO:2000785)5.21892302
44regulation of dopamine secretion (GO:0014059)5.20065709
45ventricular system development (GO:0021591)5.19622699
46calcium ion-dependent exocytosis (GO:0017156)5.16688015
47glutamine family amino acid catabolic process (GO:0009065)5.12582566
48protein polymerization (GO:0051258)5.11162607
49cell recognition (GO:0008037)5.06016994
50microtubule severing (GO:0051013)5.05288932
51regulation of cellular respiration (GO:0043457)4.99894574
52glycogen metabolic process (GO:0005977)4.98172552
53glucan metabolic process (GO:0044042)4.93629090
54cellular glucan metabolic process (GO:0006073)4.93629090
55positive regulation of glycolytic process (GO:0045821)4.92892700
56androgen biosynthetic process (GO:0006702)4.92151618
57negative regulation of cardiac muscle cell apoptotic process (GO:0010667)4.81871726
58response to acidic pH (GO:0010447)4.74184490
59* meiotic nuclear division (GO:0007126)4.67148753
60seminiferous tubule development (GO:0072520)4.61672295
61regulation of microtubule-based movement (GO:0060632)4.55775388
62mitochondrion degradation (GO:0000422)4.55076790
63coenzyme catabolic process (GO:0009109)4.50013960
64tongue development (GO:0043586)4.49967950
65meiosis I (GO:0007127)4.47334445
66regulation of synaptic transmission, dopaminergic (GO:0032225)4.43759764
67oogenesis (GO:0048477)4.33170838
68membrane repolarization during action potential (GO:0086011)4.30981375
69regulation of vacuole organization (GO:0044088)4.29848405
70* multicellular organismal reproductive process (GO:0048609)4.29330009
71cellular biogenic amine biosynthetic process (GO:0042401)4.26313494
72amine biosynthetic process (GO:0009309)4.21497669
73regulation of phosphatase activity (GO:0010921)4.06228029
74monoubiquitinated protein deubiquitination (GO:0035520)4.06186272
75dicarboxylic acid biosynthetic process (GO:0043650)4.04356517
76aspartate family amino acid catabolic process (GO:0009068)4.03213852
77positive regulation of amine transport (GO:0051954)4.02596589
78diacylglycerol metabolic process (GO:0046339)3.94247613
79meiotic cell cycle (GO:0051321)3.90719981
80protein polyglutamylation (GO:0018095)3.90670539
81phosphatidylethanolamine biosynthetic process (GO:0006646)3.88811001
82cellular response to toxic substance (GO:0097237)3.87476825
83chaperone-mediated protein complex assembly (GO:0051131)3.87435229
84protein localization to cilium (GO:0061512)3.86128642
85negative regulation of smooth muscle contraction (GO:0045986)3.85931230
86chromosome condensation (GO:0030261)3.85753488
87negative regulation of JNK cascade (GO:0046329)3.82581607
88glycerol ether metabolic process (GO:0006662)3.82388771
89negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway (GO:1902176)3.81381929
90polyamine metabolic process (GO:0006595)3.81323750
91membrane repolarization (GO:0086009)3.80907449
92left/right pattern formation (GO:0060972)3.80579811
93DNA double-strand break processing (GO:0000729)3.75981719
94DNA packaging (GO:0006323)3.71701379
95single strand break repair (GO:0000012)3.70568123
96oligosaccharide biosynthetic process (GO:0009312)3.63931757
97genitalia morphogenesis (GO:0035112)3.63026740
98regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.59133435
99phosphatidylethanolamine metabolic process (GO:0046337)3.53471368
100ether metabolic process (GO:0018904)3.52981143
101multicellular organismal development (GO:0007275)3.50352457
102synapsis (GO:0007129)3.48340681
103cellular polysaccharide metabolic process (GO:0044264)3.44874838
104sexual reproduction (GO:0019953)3.43521346
105histone H3-K9 demethylation (GO:0033169)3.39307348
106protein K11-linked deubiquitination (GO:0035871)3.38762136
107negative regulation of stress-activated MAPK cascade (GO:0032873)3.37097782
108negative regulation of stress-activated protein kinase signaling cascade (GO:0070303)3.37097782
109intraciliary transport (GO:0042073)3.34892628
110tryptophan catabolic process (GO:0006569)3.33751981
111indole-containing compound catabolic process (GO:0042436)3.33751981
112indolalkylamine catabolic process (GO:0046218)3.33751981
113meiotic cell cycle process (GO:1903046)3.30682176
114gene silencing by RNA (GO:0031047)3.28960612
115potassium ion import (GO:0010107)3.27384332
116regulation of spindle checkpoint (GO:0090231)3.26252417
117polysaccharide metabolic process (GO:0005976)3.23229505
118negative regulation of organelle assembly (GO:1902116)3.20863732
119regulation of dephosphorylation (GO:0035303)3.19864763
120regulation of synaptic vesicle transport (GO:1902803)3.18063378
121carnitine transport (GO:0015879)3.16423171
122amino-acid betaine transport (GO:0015838)3.16423171
123negative regulation of reactive oxygen species metabolic process (GO:2000378)3.16343318
124protein refolding (GO:0042026)3.14499384
125cellular response to pH (GO:0071467)3.14331535
126carnitine transmembrane transport (GO:1902603)3.12074518
127microtubule-based movement (GO:0007018)3.10714581
128negative regulation of striated muscle cell apoptotic process (GO:0010664)3.10526142
129sex determination (GO:0007530)3.09600236
130regulation of centriole replication (GO:0046599)3.08548442
131dicarboxylic acid catabolic process (GO:0043649)3.08001771
132peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)3.04716488
133detection of chemical stimulus involved in sensory perception of smell (GO:0050911)3.03616249
134axoneme assembly (GO:0035082)2.98755925
135cilium organization (GO:0044782)2.97489270
136nucleus organization (GO:0006997)2.97121621
137lactate metabolic process (GO:0006089)2.93784763
138nucleoside diphosphate phosphorylation (GO:0006165)2.88472214
139polyol catabolic process (GO:0046174)2.87609236
140microtubule polymerization or depolymerization (GO:0031109)2.87200320
141centriole replication (GO:0007099)2.83739600
142centriole assembly (GO:0098534)2.83058174
143nuclear pore complex assembly (GO:0051292)2.82278902
144cilium assembly (GO:0042384)2.81983438
145glycolytic process (GO:0006096)2.81878297
146cellular component assembly involved in morphogenesis (GO:0010927)2.81616420
147sequestering of actin monomers (GO:0042989)2.81080679
148alditol metabolic process (GO:0019400)2.78731289
149cilium morphogenesis (GO:0060271)2.68572226
150positive regulation of macrophage activation (GO:0043032)2.67302719
151GTP biosynthetic process (GO:0006183)2.66414692
152regulation of meiosis I (GO:0060631)2.63862484
153interferon-gamma secretion (GO:0072643)2.63559652
154histone exchange (GO:0043486)2.62393244
155gene silencing (GO:0016458)2.60060892
156mitotic sister chromatid cohesion (GO:0007064)2.58832491
157peptidyl-glutamic acid modification (GO:0018200)2.50673646
158fusion of sperm to egg plasma membrane (GO:0007342)13.2880640
159cell wall macromolecule catabolic process (GO:0016998)12.9054905
160cell wall macromolecule metabolic process (GO:0044036)12.9054905
161sperm motility (GO:0030317)12.5646231
162cilium or flagellum-dependent cell motility (GO:0001539)12.3060398
163acrosome assembly (GO:0001675)12.1891102
164positive regulation of synaptic transmission, dopaminergic (GO:0032226)11.8928467
165sperm-egg recognition (GO:0035036)11.6192889
166regulation of phosphoprotein phosphatase activity (GO:0043666)11.3889850
167multicellular organism reproduction (GO:0032504)11.2373166
168acrosome reaction (GO:0007340)10.7446925
169positive regulation of catecholamine secretion (GO:0033605)10.6760513
170binding of sperm to zona pellucida (GO:0007339)10.5000376
171cell-cell recognition (GO:0009988)10.4009469
172plasma membrane fusion (GO:0045026)10.1410147
173axonemal dynein complex assembly (GO:0070286)10.1091520

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse5.11323539
2IGF1R_20145208_ChIP-Seq_DFB_Human4.91970064
3EZH2_22144423_ChIP-Seq_EOC_Human4.60347901
4ESR1_20079471_ChIP-ChIP_T-47D_Human4.15259831
5BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.50981447
6VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human3.30598465
7GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.76342887
8PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.52769034
9FLI1_27457419_Chip-Seq_LIVER_Mouse2.33087721
10CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.29426625
11ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.28626619
12CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.16629843
13VDR_22108803_ChIP-Seq_LS180_Human2.15553582
14ZNF274_21170338_ChIP-Seq_K562_Hela2.11913363
15PCGF2_27294783_Chip-Seq_ESCs_Mouse2.11309563
16GATA1_26923725_Chip-Seq_HPCs_Mouse2.09315071
17FUS_26573619_Chip-Seq_HEK293_Human2.08728556
18HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.08465055
19MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.04396811
20AHR_22903824_ChIP-Seq_MCF-7_Human2.02923464
21ARNT_22903824_ChIP-Seq_MCF-7_Human2.01772247
22FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse10.7572182
23MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse10.7226384
24BP1_19119308_ChIP-ChIP_Hs578T_Human10.1297464
25EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.93223630
26AR_21909140_ChIP-Seq_LNCAP_Human1.89959369
27KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.89468783
28STAT6_21828071_ChIP-Seq_BEAS2B_Human1.86526560
29AR_21572438_ChIP-Seq_LNCaP_Human1.84409911
30NANOG_20526341_ChIP-Seq_ESCs_Human1.78369722
31TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.76694842
32RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.74773320
33ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.73360210
34KAP1_22055183_ChIP-Seq_ESCs_Mouse1.70685993
35ELK4_26923725_Chip-Seq_MESODERM_Mouse1.70103196
36CBX2_27304074_Chip-Seq_ESCs_Mouse1.66224457
37CTBP1_25329375_ChIP-Seq_LNCAP_Human1.65730091
38GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.60385363
39GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.60274912
40RAC3_21632823_ChIP-Seq_H3396_Human1.56965509
41CTCF_27219007_Chip-Seq_Bcells_Human1.56527867
42STAT1_17558387_ChIP-Seq_HELA_Human1.56438474
43GBX2_23144817_ChIP-Seq_PC3_Human1.54652674
44FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.54131428
45PCGF2_27294783_Chip-Seq_NPCs_Mouse1.53692193
46ER_23166858_ChIP-Seq_MCF-7_Human1.50878513
47GATA3_21867929_ChIP-Seq_CD8_Mouse1.49948544
48OCT1_27270436_Chip-Seq_PROSTATE_Human1.48194654
49MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.48106999
50SMC4_20622854_ChIP-Seq_HELA_Human1.46978015
51KDM2B_26808549_Chip-Seq_REH_Human1.46871818
52TAL1_26923725_Chip-Seq_HPCs_Mouse1.46373978
53WDR5_24793694_ChIP-Seq_LNCAP_Human1.46371498
54ERA_21632823_ChIP-Seq_H3396_Human1.44379944
55NFE2_27457419_Chip-Seq_LIVER_Mouse1.43577764
56ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.43162564
57SOX2_22085726_ChIP-Seq_NPCs_Mouse1.42137162
58SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.41763921
59OCT4_20526341_ChIP-Seq_ESCs_Human1.40215693
60CBP_20019798_ChIP-Seq_JUKART_Human1.38703241
61IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.38703241
62SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.38399771
63MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.38276359
64CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.37128555
65GATA1_22025678_ChIP-Seq_K562_Human1.34819839
66SUZ12_27294783_Chip-Seq_NPCs_Mouse1.34568252
67TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.31745728
68BCAT_22108803_ChIP-Seq_LS180_Human1.31657143
69SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.31155354
70FLI1_21867929_ChIP-Seq_TH2_Mouse1.30502680
71REST_21632747_ChIP-Seq_MESCs_Mouse1.30274754
72LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.30209530
73E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.29757625
74CTBP2_25329375_ChIP-Seq_LNCAP_Human1.29404604
75KLF5_20875108_ChIP-Seq_MESCs_Mouse1.28475403
76GATA3_21867929_ChIP-Seq_TH1_Mouse1.27239231
77PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.26740850
78ZFP57_27257070_Chip-Seq_ESCs_Mouse1.26277019
79MYC_19829295_ChIP-Seq_ESCs_Human1.25125690
80TBL1_22424771_ChIP-Seq_293T_Human1.23808957
81UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.22702260
82TP53_18474530_ChIP-ChIP_U2OS_Human1.21075563
83NANOG_18555785_Chip-Seq_ESCs_Mouse1.18303875
84OCT4_18555785_Chip-Seq_ESCs_Mouse1.17021544
85CRX_20693478_ChIP-Seq_RETINA_Mouse1.17007058
86FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.13723425
87SMAD3_21741376_ChIP-Seq_EPCs_Human1.13283004
88RUNX1_26923725_Chip-Seq_HPCs_Mouse1.12918330
89P53_21459846_ChIP-Seq_SAOS-2_Human1.12461915
90EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.12366952
91SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.12134461
92ZNF263_19887448_ChIP-Seq_K562_Human1.11537961
93TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10673072
94RNF2_27304074_Chip-Seq_NSC_Mouse1.10521711
95P53_22387025_ChIP-Seq_ESCs_Mouse1.09200825
96RUNX2_22187159_ChIP-Seq_PCA_Human1.08868326
97GF1_26923725_Chip-Seq_HPCs_Mouse1.08581399
98CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.08114089
99P300_18555785_Chip-Seq_ESCs_Mouse1.07398299
100CMYC_18555785_Chip-Seq_ESCs_Mouse1.06872810
101KLF4_18555785_Chip-Seq_ESCs_Mouse1.06538191
102EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.06310858
103CTCF_20526341_ChIP-Seq_ESCs_Human1.06144793
104VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.05127277
105SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.05023442
106MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.04975274
107SPI1_20517297_ChIP-Seq_HL60_Human1.04413764
108PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.04282585
109NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.04084779
110FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.03558924
111RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.03530457
112TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03288715
113POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.03288715
114ESRRB_18555785_Chip-Seq_ESCs_Mouse1.03237204
115CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.03195538
116P53_22127205_ChIP-Seq_FIBROBLAST_Human1.02986873
117SPI1_26923725_Chip-Seq_HPCs_Mouse1.02978378
118MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.02879532
119CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.02623797
120RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.00489647
121EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.00295718
122P300_19829295_ChIP-Seq_ESCs_Human1.00242666
123RAD21_21589869_ChIP-Seq_MESCs_Mouse0.99470891
124EZH2_27294783_Chip-Seq_NPCs_Mouse0.99237790
125OCT4_21477851_ChIP-Seq_ESCs_Mouse0.99031625
126EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.97906556
127STAT3_18555785_Chip-Seq_ESCs_Mouse0.97360699
128ESET_19884257_ChIP-Seq_ESCs_Mouse0.97185576
129SUZ12_18555785_Chip-Seq_ESCs_Mouse0.97043997
130RARA_24833708_ChIP-Seq_LIVER_Mouse0.95634586
131SMAD4_21799915_ChIP-Seq_A2780_Human0.95469536
132PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.95066475
133PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.95000442
134CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.94533094
135YY1_22570637_ChIP-Seq_MALME-3M_Human0.94147149
136EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.93940308
137IRF8_21731497_ChIP-ChIP_J774_Mouse0.93187535
138PKCTHETA_26484144_Chip-Seq_BREAST_Human0.93157922
139LXR_22292898_ChIP-Seq_THP-1_Human0.92964125
140SMAD4_21741376_ChIP-Seq_EPCs_Human0.92802521
141RXR_22108803_ChIP-Seq_LS180_Human0.91919754
142ERG_20517297_ChIP-Seq_VCAP_Human0.91514218
143P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.91383303
144NANOG_19829295_ChIP-Seq_ESCs_Human0.91370424
145SOX2_19829295_ChIP-Seq_ESCs_Human0.91370424
146CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.91360074
147SOX9_26525672_Chip-Seq_HEART_Mouse0.91355813
148ELF5_23300383_ChIP-Seq_T47D_Human0.90885369
149SOX2_18555785_Chip-Seq_ESCs_Mouse0.90866019
150TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.90005133
151P300_27268052_Chip-Seq_Bcells_Human0.89685264
152LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.89450532
153CTCF_18555785_Chip-Seq_ESCs_Mouse0.89197652
154RUNX1_27457419_Chip-Seq_LIVER_Mouse0.88803268
155SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.88723800
156PRDM14_20953172_ChIP-Seq_ESCs_Human0.88489171
157PU1_27457419_Chip-Seq_LIVER_Mouse0.87719539
158FLI1_21867929_ChIP-Seq_CD8_Mouse0.87594276
159PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.87412944
160RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.87261017
161RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.87088246
162NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.86651936
163E2F1_18555785_Chip-Seq_ESCs_Mouse0.86154261
164TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.85002500
165AR_25329375_ChIP-Seq_VCAP_Human0.84572442
166PHF8_20622854_ChIP-Seq_HELA_Human0.84192252
167HOXB7_26014856_ChIP-Seq_BT474_Human0.84092350
168P68_20966046_ChIP-Seq_HELA_Human0.82509295
169RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.80460296
170GF1B_26923725_Chip-Seq_HPCs_Mouse0.80223541
171EED_16625203_ChIP-ChIP_MESCs_Mouse0.78887113
172E2F1_17053090_ChIP-ChIP_MCF-7_Human0.78779244
173AUTS2_25519132_ChIP-Seq_293T-REX_Human0.78625479
174PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.76305445
175FOXH1_21741376_ChIP-Seq_ESCs_Human0.75356559
176CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.75206659
177TOP2B_26459242_ChIP-Seq_MCF-7_Human0.74560044
178GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.73551187
179TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.71713634
180SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.70295581

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003315_abnormal_perineum_morphology7.58765279
2MP0008004_abnormal_stomach_pH6.64320655
3MP0003698_abnormal_male_reproductive6.06871406
4MP0001929_abnormal_gametogenesis5.60886471
5MP0008877_abnormal_DNA_methylation5.00346493
6MP0005360_urolithiasis4.07462971
7MP0002210_abnormal_sex_determination3.79194569
8MP0002161_abnormal_fertility/fecundity3.30198728
9MP0002653_abnormal_ependyma_morphology3.26726839
10MP0001145_abnormal_male_reproductive3.23094653
11MP0005058_abnormal_lysosome_morphology3.01909164
12MP0003045_fibrosis3.00977816
13MP0000537_abnormal_urethra_morphology2.89932877
14MP0000653_abnormal_sex_gland2.80007791
15MP0002132_abnormal_respiratory_system2.47130209
16MP0003136_yellow_coat_color2.32265684
17MP0010386_abnormal_urinary_bladder2.26857395
18MP0001664_abnormal_digestion2.10953676
19MP0005623_abnormal_meninges_morphology2.03640665
20MP0005499_abnormal_olfactory_system2.01439019
21MP0005394_taste/olfaction_phenotype2.01439019
22MP0010368_abnormal_lymphatic_system2.01319908
23MP0005410_abnormal_fertilization15.3525009
24MP0002160_abnormal_reproductive_system1.92963412
25MP0005187_abnormal_penis_morphology1.91223514
26MP0005670_abnormal_white_adipose1.88445064
27MP0000538_abnormal_urinary_bladder1.73995081
28MP0001188_hyperpigmentation1.68688326
29MP0001905_abnormal_dopamine_level1.65753579
30MP0008058_abnormal_DNA_repair1.64695322
31MP0009046_muscle_twitch1.64191298
32MP0004233_abnormal_muscle_weight1.50248697
33MP0003646_muscle_fatigue1.48949816
34MP0006072_abnormal_retinal_apoptosis1.48846662
35MP0001849_ear_inflammation1.47810044
36MP0008057_abnormal_DNA_replication1.47483736
37MP0000465_gastrointestinal_hemorrhage1.39253546
38MP0009697_abnormal_copulation1.36254310
39MP0004272_abnormal_basement_membrane1.30657679
40MP0001984_abnormal_olfaction1.24740034
41MP0010094_abnormal_chromosome_stability1.22738700
42MP0003718_maternal_effect1.19778896
43MP0002282_abnormal_trachea_morphology1.19151396
44MP0003632_abnormal_nervous_system1.10236117
45MP0000343_altered_response_to1.09349797
46MP0005409_darkened_coat_color1.07228457
47MP0005389_reproductive_system_phenotype1.04003993
48MP0005395_other_phenotype1.03702021
49MP0005647_abnormal_sex_gland1.01786566
50MP0005646_abnormal_pituitary_gland1.01614084
51MP0003936_abnormal_reproductive_system1.01002128
52MP0001765_abnormal_ion_homeostasis0.97922213
53MP0005248_abnormal_Harderian_gland0.97262340
54MP0002127_abnormal_cardiovascular_syste0.94815171
55MP0001501_abnormal_sleep_pattern0.91797390
56MP0002168_other_aberrant_phenotype0.90472479
57MP0004085_abnormal_heartbeat0.87470140
58MP0003806_abnormal_nucleotide_metabolis0.86467087
59MP0001529_abnormal_vocalization0.86250887
60MP0010234_abnormal_vibrissa_follicle0.84155829
61MP0000470_abnormal_stomach_morphology0.83995686
62MP0002249_abnormal_larynx_morphology0.82656750
63MP0003786_premature_aging0.76766556
64MP0000678_abnormal_parathyroid_gland0.73912128
65MP0008995_early_reproductive_senescence0.72323768
66MP0001661_extended_life_span0.72284971
67MP0008007_abnormal_cellular_replicative0.72032302
68MP0002233_abnormal_nose_morphology0.71205727
69MP0000631_abnormal_neuroendocrine_gland0.70559903
70MP0003111_abnormal_nucleus_morphology0.69501220
71MP0008789_abnormal_olfactory_epithelium0.69447987
72MP0002234_abnormal_pharynx_morphology0.66513698
73MP0004381_abnormal_hair_follicle0.60721765
74MP0003385_abnormal_body_wall0.60241757
75MP0005174_abnormal_tail_pigmentation0.59654758
76MP0000358_abnormal_cell_content/0.58742330
77MP0003878_abnormal_ear_physiology0.58430804
78MP0005377_hearing/vestibular/ear_phenot0.58430804
79MP0003699_abnormal_female_reproductive0.57810727
80MP0003329_amyloid_beta_deposits0.57366992
81MP0003011_delayed_dark_adaptation0.57206936
82MP0002998_abnormal_bone_remodeling0.55470934
83MP0003950_abnormal_plasma_membrane0.54457252
84MP0000230_abnormal_systemic_arterial0.54299591
85MP0004036_abnormal_muscle_relaxation0.52732179
86MP0005595_abnormal_vascular_smooth0.52438109
87MP0003938_abnormal_ear_development0.52021314
88MP0010307_abnormal_tumor_latency0.50412430
89MP0001756_abnormal_urination0.49951098
90MP0002090_abnormal_vision0.49934394
91MP0005620_abnormal_muscle_contractility0.49835567
92MP0002736_abnormal_nociception_after0.49082333
93MP0004782_abnormal_surfactant_physiolog0.49006952
94MP0005636_abnormal_mineral_homeostasis0.48040191
95MP0006036_abnormal_mitochondrial_physio0.47051873
96MP0002102_abnormal_ear_morphology0.47040341
97MP0009840_abnormal_foam_cell0.46991003
98MP0001270_distended_abdomen0.46696283
99MP0001293_anophthalmia0.46688100
100MP0001545_abnormal_hematopoietic_system0.45960469
101MP0005397_hematopoietic_system_phenotyp0.45960469
102MP0004133_heterotaxia0.45947978
103MP0001730_embryonic_growth_arrest0.45889028
104MP0002269_muscular_atrophy0.44968108
105MP0005166_decreased_susceptibility_to0.44047888
106MP0003115_abnormal_respiratory_system0.43979945
107MP0001119_abnormal_female_reproductive0.43713956
108MP0000762_abnormal_tongue_morphology0.43543495
109MP0000747_muscle_weakness0.42597443
110MP0004270_analgesia0.42506107
111MP0001968_abnormal_touch/_nociception0.41808067
112MP0003633_abnormal_nervous_system0.41567097
113MP0000462_abnormal_digestive_system0.41053554
114MP0004859_abnormal_synaptic_plasticity0.40934720
115MP0002928_abnormal_bile_duct0.40609755
116MP0002638_abnormal_pupillary_reflex0.40466849
117MP0000049_abnormal_middle_ear0.39391036
118MP0003868_abnormal_feces_composition0.38174857
119MP0005551_abnormal_eye_electrophysiolog0.36943551
120MP0004811_abnormal_neuron_physiology0.36921977
121MP0001764_abnormal_homeostasis0.36657531
122MP0003077_abnormal_cell_cycle0.36407584
123MP0001324_abnormal_eye_pigmentation0.36173552
124MP0003631_nervous_system_phenotype0.35839950
125MP0000920_abnormal_myelination0.35281092
126MP0005253_abnormal_eye_physiology0.34483456
127MP0002752_abnormal_somatic_nervous0.34368505
128MP0009250_abnormal_appendicular_skeleto0.33454293
129MP0002115_abnormal_skeleton_extremities0.32884181
130MP0000313_abnormal_cell_death0.32876268
131MP0004808_abnormal_hematopoietic_stem0.32780982
132MP0003879_abnormal_hair_cell0.32171902
133MP0003861_abnormal_nervous_system0.32097071
134MP0000026_abnormal_inner_ear0.31188270
135MP0004019_abnormal_vitamin_homeostasis0.30591093
136MP0002152_abnormal_brain_morphology0.30058392
137MP0006035_abnormal_mitochondrial_morpho0.29882730
138MP0009278_abnormal_bone_marrow0.28298781
139MP0005391_vision/eye_phenotype0.27783879
140MP0000569_abnormal_digit_pigmentation0.27641833
141MP0002084_abnormal_developmental_patter0.27433601
142MP0004134_abnormal_chest_morphology0.25951737
143MP0004084_abnormal_cardiac_muscle0.25560483
144MP0000604_amyloidosis0.25367986
145MP0009115_abnormal_fat_cell0.25013337
146MP0002572_abnormal_emotion/affect_behav0.24822861
147MP0000427_abnormal_hair_cycle0.23144769
148MP0004145_abnormal_muscle_electrophysio0.22795046
149MP0002229_neurodegeneration0.22677157
150MP0002971_abnormal_brown_adipose0.22256451
151MP0005666_abnormal_adipose_tissue0.21838052
152MP0001727_abnormal_embryo_implantation0.21584788
153MP0001697_abnormal_embryo_size0.21386408
154MP0002169_no_abnormal_phenotype0.21335305
155MP0002873_normal_phenotype0.21107086
156MP0001440_abnormal_grooming_behavior0.20778371
157MP0001672_abnormal_embryogenesis/_devel0.20465107
158MP0005380_embryogenesis_phenotype0.20465107
159MP0003635_abnormal_synaptic_transmissio0.20365278
160MP0008872_abnormal_physiological_respon0.19717148
161MP0003693_abnormal_embryo_hatching0.19126550
162MP0001919_abnormal_reproductive_system0.19056618
163MP0002822_catalepsy0.18609448
164MP0001986_abnormal_taste_sensitivity0.18199341
165MP0000534_abnormal_ureter_morphology0.18129567
166MP0002735_abnormal_chemical_nociception0.18118138
167MP0002272_abnormal_nervous_system0.18083870
168MP0009745_abnormal_behavioral_response0.18056380
169MP0002080_prenatal_lethality0.17853728
170MP0002085_abnormal_embryonic_tissue0.16723184

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)9.42182045
2Abnormal respiratory motile cilium morphology (HP:0005938)8.82160713
3Abnormal respiratory epithelium morphology (HP:0012253)8.82160713
4Sex reversal (HP:0012245)8.55078827
5Abnormal sex determination (HP:0012244)8.55078827
6Rhinitis (HP:0012384)7.89094918
7Resting tremor (HP:0002322)7.88238587
8Hypoplasia of the uterus (HP:0000013)7.74366882
9Abnormal ciliary motility (HP:0012262)7.62869852
10Chronic bronchitis (HP:0004469)7.31433155
11Nasal polyposis (HP:0100582)6.32694355
12Infertility (HP:0000789)6.28507814
13Gonadal dysgenesis (HP:0000133)5.91966363
14Reduced antithrombin III activity (HP:0001976)5.84327915
15Abnormality of the columella (HP:0009929)5.83920330
16Aplasia/hypoplasia of the uterus (HP:0008684)5.80596195
17Colitis (HP:0002583)5.26356990
18Abnormality of the nasal mucosa (HP:0000433)5.16434307
19Postural instability (HP:0002172)4.83445665
20Male pseudohermaphroditism (HP:0000037)4.80226197
21Germ cell neoplasia (HP:0100728)4.68815878
22Ventricular fibrillation (HP:0001663)4.66647454
23Facial hemangioma (HP:0000329)4.64428299
24Bronchiectasis (HP:0002110)4.53538367
25Bronchitis (HP:0012387)4.47521756
26Nephronophthisis (HP:0000090)4.43340357
27Thoracic kyphosis (HP:0002942)4.07224272
28Urinary urgency (HP:0000012)4.02329863
29Thoracolumbar scoliosis (HP:0002944)3.91840795
30Male infertility (HP:0003251)3.70550612
31Self-mutilation (HP:0000742)3.57830611
32Abnormality of the intrinsic pathway (HP:0010989)3.55924852
33Abnormal spermatogenesis (HP:0008669)3.43114336
34Inflammation of the large intestine (HP:0002037)3.37267787
35Type II lissencephaly (HP:0007260)3.37155405
36Abnormality of the renal medulla (HP:0100957)3.33046008
37Recurrent sinusitis (HP:0011108)3.28454717
38Recurrent otitis media (HP:0000403)3.23095465
39Abnormality of the lumbar spine (HP:0100712)3.21740906
40Retinal atrophy (HP:0001105)3.21739753
41Capillary hemangiomas (HP:0005306)3.21554308
42Gastrointestinal inflammation (HP:0004386)3.13767991
43Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)3.12540829
44Medial flaring of the eyebrow (HP:0010747)2.98611607
45Protruding tongue (HP:0010808)2.96959106
46Abnormality of the lower motor neuron (HP:0002366)2.91307807
47Sensory axonal neuropathy (HP:0003390)2.89119233
48Abnormality of midbrain morphology (HP:0002418)2.88903246
49Molar tooth sign on MRI (HP:0002419)2.88903246
50Atonic seizures (HP:0010819)2.87258989
51Tubulointerstitial nephritis (HP:0001970)2.73768457
52Tubular atrophy (HP:0000092)2.71221342
53Abnormality of the thoracic spine (HP:0100711)2.67500286
54Occipital encephalocele (HP:0002085)2.63533167
55Abnormality of male internal genitalia (HP:0000022)2.63484912
56Azoospermia (HP:0000027)2.59905891
57Recurrent bronchitis (HP:0002837)2.58247490
58Buphthalmos (HP:0000557)2.54134983
59Abnormality of the frontal sinuses (HP:0002687)2.53051459
60Gonadotropin excess (HP:0000837)2.52650560
61Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.52522981
62Decreased activity of mitochondrial respiratory chain (HP:0008972)2.52522981
63Congenital sensorineural hearing impairment (HP:0008527)2.48000043
64Aplasia/Hypoplasia involving the sinuses (HP:0009120)2.47744740
65Unsteady gait (HP:0002317)2.44846024
66Absent thumb (HP:0009777)2.39646955
67Tubulointerstitial abnormality (HP:0001969)2.39372766
68Decreased number of peripheral myelinated nerve fibers (HP:0003380)2.36970958
69Anterior segment dysgenesis (HP:0007700)2.34660387
70Impulsivity (HP:0100710)2.30968648
71Inability to walk (HP:0002540)2.25930541
72Facial diplegia (HP:0001349)2.23698020
73Syncope (HP:0001279)2.23409515
74Spinal rigidity (HP:0003306)2.23168307
75Prolonged QT interval (HP:0001657)2.21550267
76Amyotrophic lateral sclerosis (HP:0007354)2.20032307
77Absent rod-and cone-mediated responses on ERG (HP:0007688)2.19365044
78Hypothermia (HP:0002045)2.17411471
79Fibular hypoplasia (HP:0003038)2.16526182
80Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.12502787
81Postaxial foot polydactyly (HP:0001830)2.12229739
82Respiratory insufficiency due to defective ciliary clearance (HP:0200073)13.6708361
83Dynein arm defect of respiratory motile cilia (HP:0012255)12.5269740
84Absent/shortened dynein arms (HP:0200106)12.5269740
85Centrally nucleated skeletal muscle fibers (HP:0003687)1.97828007
86Abnormality of the ileum (HP:0001549)1.97231265
87Congenital hepatic fibrosis (HP:0002612)1.97035747
88High anterior hairline (HP:0009890)1.96552823
89Polyneuropathy (HP:0001271)1.95759286
90Tubulointerstitial fibrosis (HP:0005576)1.95564904
91Hypoplasia of the capital femoral epiphysis (HP:0003090)1.94510395
92Microglossia (HP:0000171)1.93553129
93Aortic aneurysm (HP:0004942)1.93405304
94Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.91673657
95Abnormal protein N-linked glycosylation (HP:0012347)1.91673657
96Abnormal protein glycosylation (HP:0012346)1.91673657
97Abnormal glycosylation (HP:0012345)1.91673657
98Coxa valga (HP:0002673)1.90218397
99Difficulty climbing stairs (HP:0003551)1.87505089
100Stage 5 chronic kidney disease (HP:0003774)1.85597817
101Generalized hypotonia (HP:0001290)1.84203405
102Facial cleft (HP:0002006)1.83804338
103Aplasia cutis congenita (HP:0001057)1.82611849
104Polydipsia (HP:0001959)1.82207864
105Abnormal drinking behavior (HP:0030082)1.82207864
106Short ribs (HP:0000773)1.82081084
107Aplasia/Hypoplasia of the uvula (HP:0010293)1.80432630
108Oculomotor apraxia (HP:0000657)1.80410967
109Congenital primary aphakia (HP:0007707)1.79393215
110Gait imbalance (HP:0002141)1.78931040
111Absent speech (HP:0001344)1.78011106
112Abnormality of the renal cortex (HP:0011035)1.75452480
113Pancreatic fibrosis (HP:0100732)1.74707998
114Meckel diverticulum (HP:0002245)1.73061969
115Depression (HP:0000716)1.71301625
116Postaxial hand polydactyly (HP:0001162)1.71103053
117Chronic sinusitis (HP:0011109)1.70723416
118Bradykinesia (HP:0002067)1.70035665
119Impaired proprioception (HP:0010831)1.69692156
120J-shaped sella turcica (HP:0002680)1.69462552
121Renal dysplasia (HP:0000110)1.68835632
122Flattened epiphyses (HP:0003071)1.68720556
123Cholecystitis (HP:0001082)1.67060405
124Abnormal gallbladder physiology (HP:0012438)1.67060405
125Squamous cell carcinoma (HP:0002860)1.65888953
126Tongue fasciculations (HP:0001308)1.64246016
127Absent frontal sinuses (HP:0002688)1.64020104
128Median cleft lip (HP:0000161)1.63000124
129Atrial fibrillation (HP:0005110)1.61668592
130Vitreoretinal degeneration (HP:0000655)1.60543804
131Abnormality of the dental root (HP:0006486)1.59884947
132Taurodontia (HP:0000679)1.59884947
133Abnormality of permanent molar morphology (HP:0011071)1.59884947
134Supernumerary spleens (HP:0009799)1.59813560
135Exercise-induced myalgia (HP:0003738)1.59526065
136Anxiety (HP:0000739)1.59231926
137Abnormality of ocular smooth pursuit (HP:0000617)1.59008385
138Aplasia/Hypoplasia of the tongue (HP:0010295)1.58532546
139Abnormality of renal excretion (HP:0011036)1.55826270
140Congenital glaucoma (HP:0001087)1.55225911
141Upper motor neuron abnormality (HP:0002127)1.54792075
142Nephrogenic diabetes insipidus (HP:0009806)1.54554249
143Abnormality of saccadic eye movements (HP:0000570)1.54482257
144High pitched voice (HP:0001620)1.53340335
145Hypoplasia of the brainstem (HP:0002365)1.52950239
146Aplasia/Hypoplasia of the brainstem (HP:0007362)1.52950239
147Bile duct proliferation (HP:0001408)1.52412677
148Abnormal biliary tract physiology (HP:0012439)1.52412677
149Spastic tetraparesis (HP:0001285)1.52121562
150Abnormality of the anterior horn cell (HP:0006802)1.51145160
151Degeneration of anterior horn cells (HP:0002398)1.51145160
152Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.50559234
153Absent epiphyses (HP:0010577)1.50559234
154Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.50396164
155Intellectual disability, progressive (HP:0006887)1.49483656
156Cystic liver disease (HP:0006706)1.49147123
157Aplasia/Hypoplasia of the lens (HP:0008063)1.48357126
158Abnormality of molar morphology (HP:0011070)1.48279311
159Abnormality of molar (HP:0011077)1.48279311
160Enlarged kidneys (HP:0000105)1.47620053
161Dyschromatopsia (HP:0007641)1.47507990
162Muscle fibrillation (HP:0010546)1.46907683
163Heterotopia (HP:0002282)1.45047821
164Abnormality of the dental pulp (HP:0006479)1.44014268
165Abnormality of dentin (HP:0010299)1.42439936
166Deformed sella turcica (HP:0002681)1.41647018
167Decreased central vision (HP:0007663)1.40697229
168Genital tract atresia (HP:0001827)1.38376153
169Aplasia/Hypoplasia of the fibula (HP:0006492)1.38089972
170Poor coordination (HP:0002370)1.37955119
171Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.35326857
172Vaginal atresia (HP:0000148)1.32614167
173Short thorax (HP:0010306)1.32262205
174Retinal dysplasia (HP:0007973)1.30553733
175Cerebellar dysplasia (HP:0007033)1.30108608
176Optic nerve hypoplasia (HP:0000609)1.29079969
177Nephropathy (HP:0000112)1.28250420
178True hermaphroditism (HP:0010459)1.26924370
179Abnormal urine output (HP:0012590)1.23036987
180Breast carcinoma (HP:0003002)1.21093012

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK39.19535020
2PDK49.19535020
3PDK25.98216127
4TESK14.68415942
5TLK14.02058511
6ZAK3.94751413
7PRKD33.61885439
8MYLK3.37859731
9ICK3.08558701
10RPS6KA53.01713583
11PTK2B2.41175705
12WNK42.15131890
13LATS12.13235311
14STK392.09795318
15PNCK2.08568953
16NEK21.70938155
17STK381.50440851
18MST1R1.24615279
19LATS21.21850367
20CDK31.18042239
21CCNB11.11379144
22PDK11.03083377
23SGK4941.02363617
24SGK2231.02363617
25ARAF0.98069820
26WEE10.97766244
27MAP3K90.91298993
28CSNK1A1L0.90147069
29CDC42BPA0.88534340
30VRK10.83393850
31DYRK1B0.83309569
32TYRO30.79554745
33WNK10.77407002
34PASK0.77247965
35CDC70.76884258
36FRK0.76779781
37TTK0.76570751
38MAPK150.73424426
39CSNK1G30.72716955
40LMTK20.70846903
41STK30.67615542
42DYRK30.67580758
43MELK0.65810142
44OBSCN0.63576338
45MAP3K130.63209751
46MAP3K10.62568198
47FGR0.61774714
48NME20.61520230
49CHEK20.60972617
50IRAK10.59912829
51STK38L0.58053741
52PINK10.56621718
53CSNK1G10.55049444
54EIF2AK30.51982362
55DAPK30.51132089
56PLK40.50882447
57CHEK10.50194387
58CSNK1G20.49102447
59PKN10.48775582
60FGFR20.48572988
61PDPK10.48271725
62ATR0.47429682
63DYRK20.46524182
64BRSK20.44839511
65ROCK10.43973423
66EEF2K0.43476868
67MAP2K70.42890226
68CDK50.41028270
69RIPK40.40808903
70RET0.38853127
71MAP3K40.38634886
72MAP2K60.38274828
73MOS0.37347781
74PRKCG0.36821738
75TESK20.36048662
76CAMK10.34605615
77TIE10.34106236
78PAK10.33932685
79ATM0.33432080
80PLK10.32996213
81TGFBR10.31831668
82ILK0.29378411
83MUSK0.29298924
84PKN20.29105312
85CDK120.26901497
86CDK80.26578086
87CLK10.25314056
88AKT20.24424875
89CAMK1G0.23627133
90BRSK10.23212951
91NTRK20.23200390
92IRAK20.22729194
93CSNK1A10.22271398
94CAMKK10.20821214
95BUB10.19566773
96MET0.19238240
97RPS6KB10.18555557
98RPS6KA40.18496318
99ADRBK20.18392852
100AURKB0.17885453
101SGK20.17791457
102FES0.17275581
103RPS6KA30.17275295
104BRAF0.17243087
105MTOR0.16449128
106NEK60.16223082
107MAPK120.16187539
108MAPKAPK50.15928853
109MAPK10.13178297
110MARK30.12514583
111GRK10.12289525
112PAK20.12235965
113CDK150.11805488
114KSR20.11419303
115PRKAA10.11271516
116CSNK2A10.11086192
117AURKA0.10585357
118CDK180.10233993
119GRK60.10231155
120PRKCZ0.10227272
121MINK10.09785692
122CSNK2A20.09770205
123BTK0.09010190
124MAPKAPK30.08881571
125CDK20.08733562
126CDK11A0.08584267
127STK40.07743373
128CDK10.07584149
129CDK140.06798273
130ZAP700.06710310
131MARK20.06561808
132PBK0.06316491
133PAK40.06313008
134PIM10.06213365
135GSK3B0.05789580
136STK110.05033499
137WNK30.04302924
138PAK60.03057095
139BMPR1B0.02793671
140MAPK80.02670631
141PRKDC0.02567207
142MAP3K80.02249819
143MAPK100.02025686
144CAMK2A0.02023707
145PRKG10.01078756
146PRKACG0.00627473
147STK100.00608742
148PRKCQ0.00411712
149PRKACB0.00367639
150MAP3K50.00135630
151RPS6KA10.00132229
152EGFR-0.0247640
153GRK5-0.0231268
154PRKG2-0.0201655
155MAP2K4-0.0170849
156PRKCA-0.0150380
157CSNK1E-0.0103038
158MAP3K10-0.0069284
159CSNK1D-0.0019641
160PRKCB-0.0014945

Predicted pathways (KEGG)

RankGene SetZ-score
1Pathogenic Escherichia coli infection_Homo sapiens_hsa051308.58797202
2Gap junction_Homo sapiens_hsa045405.70098830
3Vitamin B6 metabolism_Homo sapiens_hsa007504.35663869
4Glycolysis / Gluconeogenesis_Homo sapiens_hsa000104.25458685
5Pyruvate metabolism_Homo sapiens_hsa006203.95737230
6Nitrogen metabolism_Homo sapiens_hsa009103.32124912
7Fatty acid biosynthesis_Homo sapiens_hsa000613.29969696
8Apoptosis_Homo sapiens_hsa042103.26009886
9Phagosome_Homo sapiens_hsa041453.05956861
10Basal transcription factors_Homo sapiens_hsa030223.03660737
11Propanoate metabolism_Homo sapiens_hsa006402.82042802
12Arginine biosynthesis_Homo sapiens_hsa002202.73362834
13Glucagon signaling pathway_Homo sapiens_hsa049222.70768911
14Pentose phosphate pathway_Homo sapiens_hsa000302.65932708
15alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.54843842
16Linoleic acid metabolism_Homo sapiens_hsa005912.48803918
17Fanconi anemia pathway_Homo sapiens_hsa034602.27635296
18Oocyte meiosis_Homo sapiens_hsa041142.18307607
19Selenocompound metabolism_Homo sapiens_hsa004502.08009688
20Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.87851755
21Huntingtons disease_Homo sapiens_hsa050161.87491801
22Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.84442739
23Dorso-ventral axis formation_Homo sapiens_hsa043201.81589734
24Amphetamine addiction_Homo sapiens_hsa050311.74523350
25Glycerolipid metabolism_Homo sapiens_hsa005611.74281605
26Carbohydrate digestion and absorption_Homo sapiens_hsa049731.62449745
27Carbon metabolism_Homo sapiens_hsa012001.61849315
28Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.61430041
29Glycosaminoglycan degradation_Homo sapiens_hsa005311.54188682
30Butanoate metabolism_Homo sapiens_hsa006501.53586817
31RNA transport_Homo sapiens_hsa030131.51430845
32Glycerophospholipid metabolism_Homo sapiens_hsa005641.45441866
33Fructose and mannose metabolism_Homo sapiens_hsa000511.44854159
34Cardiac muscle contraction_Homo sapiens_hsa042601.44072927
35Cysteine and methionine metabolism_Homo sapiens_hsa002701.43812999
36Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.34580289
37Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.34523678
38mRNA surveillance pathway_Homo sapiens_hsa030151.30646712
39Steroid hormone biosynthesis_Homo sapiens_hsa001401.28585424
40PPAR signaling pathway_Homo sapiens_hsa033201.27779376
41Renin secretion_Homo sapiens_hsa049241.27434958
42Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.26667650
43Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.22184177
44Biosynthesis of amino acids_Homo sapiens_hsa012301.21357714
45Purine metabolism_Homo sapiens_hsa002301.21001344
46Mineral absorption_Homo sapiens_hsa049781.14110895
47Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.11703193
48Fat digestion and absorption_Homo sapiens_hsa049751.10726348
49Ether lipid metabolism_Homo sapiens_hsa005651.03447733
50Long-term potentiation_Homo sapiens_hsa047201.01429005
51Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.01282056
52Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.99347301
53Collecting duct acid secretion_Homo sapiens_hsa049660.99198638
54Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.95235743
55Phenylalanine metabolism_Homo sapiens_hsa003600.93922090
56Antigen processing and presentation_Homo sapiens_hsa046120.92782717
57Glutathione metabolism_Homo sapiens_hsa004800.92220805
58Renin-angiotensin system_Homo sapiens_hsa046140.90024495
59Synaptic vesicle cycle_Homo sapiens_hsa047210.83567923
60Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.82817334
61Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.81857481
62Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.80862356
63Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.79666981
64Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.76815547
65Fatty acid metabolism_Homo sapiens_hsa012120.74082953
66Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.73996076
67Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.72741954
68Estrogen signaling pathway_Homo sapiens_hsa049150.71844297
69Systemic lupus erythematosus_Homo sapiens_hsa053220.70317811
70Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.69250512
71Calcium signaling pathway_Homo sapiens_hsa040200.67358634
72Insulin secretion_Homo sapiens_hsa049110.65880804
73Chemical carcinogenesis_Homo sapiens_hsa052040.65874764
74Fatty acid degradation_Homo sapiens_hsa000710.65679001
75Oxytocin signaling pathway_Homo sapiens_hsa049210.65109200
76Homologous recombination_Homo sapiens_hsa034400.65105763
77Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.64811955
78Central carbon metabolism in cancer_Homo sapiens_hsa052300.64461707
79Transcriptional misregulation in cancer_Homo sapiens_hsa052020.63403995
80Arachidonic acid metabolism_Homo sapiens_hsa005900.63186002
81cGMP-PKG signaling pathway_Homo sapiens_hsa040220.56825877
82Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.55710703
83Pyrimidine metabolism_Homo sapiens_hsa002400.55273464
84Circadian rhythm_Homo sapiens_hsa047100.54793657
85Tryptophan metabolism_Homo sapiens_hsa003800.53705396
86Phosphatidylinositol signaling system_Homo sapiens_hsa040700.52047097
87Taste transduction_Homo sapiens_hsa047420.51898253
88Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.51704894
89Inositol phosphate metabolism_Homo sapiens_hsa005620.50170291
90TGF-beta signaling pathway_Homo sapiens_hsa043500.49984353
91Hedgehog signaling pathway_Homo sapiens_hsa043400.49551433
92Thyroid hormone synthesis_Homo sapiens_hsa049180.47966281
93ABC transporters_Homo sapiens_hsa020100.47102633
94Proteasome_Homo sapiens_hsa030500.44819458
95Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.44047113
96Cell cycle_Homo sapiens_hsa041100.43325050
97Tyrosine metabolism_Homo sapiens_hsa003500.42618611
98Wnt signaling pathway_Homo sapiens_hsa043100.42443308
99Endometrial cancer_Homo sapiens_hsa052130.42402861
100Metabolic pathways_Homo sapiens_hsa011000.42139359
101Adipocytokine signaling pathway_Homo sapiens_hsa049200.40326496
102Salivary secretion_Homo sapiens_hsa049700.39982696
103Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.39920781
104Circadian entrainment_Homo sapiens_hsa047130.39876656
105Endocytosis_Homo sapiens_hsa041440.39579607
106RNA degradation_Homo sapiens_hsa030180.38968417
107Legionellosis_Homo sapiens_hsa051340.38930782
108AMPK signaling pathway_Homo sapiens_hsa041520.36841581
109beta-Alanine metabolism_Homo sapiens_hsa004100.35743577
110Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.35706899
111VEGF signaling pathway_Homo sapiens_hsa043700.35651491
112Pancreatic secretion_Homo sapiens_hsa049720.35211160
113Gastric acid secretion_Homo sapiens_hsa049710.34735466
114DNA replication_Homo sapiens_hsa030300.33795113
115N-Glycan biosynthesis_Homo sapiens_hsa005100.33302671
116Bile secretion_Homo sapiens_hsa049760.32215347
117Alcoholism_Homo sapiens_hsa050340.30380857
118Thyroid hormone signaling pathway_Homo sapiens_hsa049190.30018379
119Choline metabolism in cancer_Homo sapiens_hsa052310.27805384
120Vascular smooth muscle contraction_Homo sapiens_hsa042700.26947518
121Spliceosome_Homo sapiens_hsa030400.26670734
122cAMP signaling pathway_Homo sapiens_hsa040240.23682112
123Prostate cancer_Homo sapiens_hsa052150.23558552
124Longevity regulating pathway - mammal_Homo sapiens_hsa042110.23323393
125Viral carcinogenesis_Homo sapiens_hsa052030.23138379
126Olfactory transduction_Homo sapiens_hsa047400.22454334
127Sphingolipid metabolism_Homo sapiens_hsa006000.21496596
128Sphingolipid signaling pathway_Homo sapiens_hsa040710.21211132
129Sulfur metabolism_Homo sapiens_hsa009200.20931498
130Dopaminergic synapse_Homo sapiens_hsa047280.20261975
131Glutamatergic synapse_Homo sapiens_hsa047240.20245070
132B cell receptor signaling pathway_Homo sapiens_hsa046620.20239237
133ECM-receptor interaction_Homo sapiens_hsa045120.18939986
134Non-homologous end-joining_Homo sapiens_hsa034500.18661630
135Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.16667145
136T cell receptor signaling pathway_Homo sapiens_hsa046600.15885076
137Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.14780543
138Melanoma_Homo sapiens_hsa052180.14424937
139MAPK signaling pathway_Homo sapiens_hsa040100.14412348
140Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.13267024
141Dilated cardiomyopathy_Homo sapiens_hsa054140.12773929
142Focal adhesion_Homo sapiens_hsa045100.12253480
143Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.11017198
144FoxO signaling pathway_Homo sapiens_hsa040680.10580467
145Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.08709514
146SNARE interactions in vesicular transport_Homo sapiens_hsa041300.08243945
147mTOR signaling pathway_Homo sapiens_hsa041500.07438836

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