TEX33

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1reproduction (GO:0000003)9.92406575
2axonemal dynein complex assembly (GO:0070286)9.88870295
3spermatid development (GO:0007286)9.67339648
4motile cilium assembly (GO:0044458)9.57669827
5cilium or flagellum-dependent cell motility (GO:0001539)9.41852430
6cilium movement (GO:0003341)8.40827670
7regulation of cilium movement (GO:0003352)8.03649475
8epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)7.67405513
9single fertilization (GO:0007338)7.46874085
10sperm capacitation (GO:0048240)7.44568422
11synaptonemal complex organization (GO:0070193)7.01207850
12synaptonemal complex assembly (GO:0007130)6.94919464
13male meiosis (GO:0007140)6.92696023
14negative regulation of inclusion body assembly (GO:0090084)6.71741161
15piRNA metabolic process (GO:0034587)6.57100664
16spermatogenesis (GO:0007283)6.47072449
17male gamete generation (GO:0048232)6.44651353
18organic cation transport (GO:0015695)6.38898569
19microtubule depolymerization (GO:0007019)6.38404866
20fertilization (GO:0009566)6.24254691
21spermatid nucleus differentiation (GO:0007289)6.20797308
22gamete generation (GO:0007276)5.93096386
23regulation of inclusion body assembly (GO:0090083)5.68578419
24calcium ion-dependent exocytosis (GO:0017156)5.63298181
25germ cell development (GO:0007281)5.35365340
26cellular process involved in reproduction in multicellular organism (GO:0022412)5.32107185
27sexual reproduction (GO:0019953)5.21575176
28ventricular system development (GO:0021591)5.15167887
29cell recognition (GO:0008037)5.09043700
30glycerol ether metabolic process (GO:0006662)4.98427713
31single strand break repair (GO:0000012)4.80205591
32chromosome organization involved in meiosis (GO:0070192)4.71306073
33microtubule severing (GO:0051013)4.69656669
34regulation of microtubule-based movement (GO:0060632)4.69066341
35multicellular organismal reproductive process (GO:0048609)4.66768701
36chromosome condensation (GO:0030261)4.61856520
37ether metabolic process (GO:0018904)4.60693383
38DNA packaging (GO:0006323)4.37983254
39male meiosis I (GO:0007141)4.36975705
40DNA methylation involved in gamete generation (GO:0043046)4.24794830
41seminiferous tubule development (GO:0072520)4.19896703
42protein K11-linked deubiquitination (GO:0035871)4.16806681
43left/right pattern formation (GO:0060972)4.14436213
44meiotic nuclear division (GO:0007126)4.11486726
45chaperone-mediated protein complex assembly (GO:0051131)3.86329736
46multicellular organismal development (GO:0007275)3.74920772
47monoubiquitinated protein deubiquitination (GO:0035520)3.71674705
48genitalia morphogenesis (GO:0035112)3.59828939
49sequestering of actin monomers (GO:0042989)3.53465919
50meiosis I (GO:0007127)3.44433340
51protein polyglutamylation (GO:0018095)3.30439214
52microtubule polymerization or depolymerization (GO:0031109)3.29256852
53meiotic cell cycle (GO:0051321)3.15786835
54polyol catabolic process (GO:0046174)3.14965159
55protein refolding (GO:0042026)3.11811346
56glycolytic process (GO:0006096)3.11543367
57positive regulation of macrophage activation (GO:0043032)3.06091851
58nucleus organization (GO:0006997)3.05806330
59alditol metabolic process (GO:0019400)3.02403199
60protein localization to cilium (GO:0061512)2.98694892
61carnitine transport (GO:0015879)2.96932403
62amino-acid betaine transport (GO:0015838)2.96932403
63regulation of spindle checkpoint (GO:0090231)2.96822851
64nucleoside diphosphate phosphorylation (GO:0006165)2.93264256
65cilium organization (GO:0044782)2.90554355
66interferon-gamma secretion (GO:0072643)2.86658508
67centriole assembly (GO:0098534)2.82409212
68cilium assembly (GO:0042384)2.80742051
69carnitine transmembrane transport (GO:1902603)2.80546922
70microtubule-based movement (GO:0007018)2.77073773
71cellular component assembly involved in morphogenesis (GO:0010927)2.74889356
72polyamine biosynthetic process (GO:0006596)2.72686660
73GTP biosynthetic process (GO:0006183)2.72249235
74chromatin silencing (GO:0006342)2.71908232
75intraciliary transport (GO:0042073)2.70113488
76mitotic sister chromatid cohesion (GO:0007064)2.67518877
77synapsis (GO:0007129)2.65747168
78cilium morphogenesis (GO:0060271)2.65419234
79meiotic cell cycle process (GO:1903046)2.64667752
80glycerol metabolic process (GO:0006071)2.61992081
81lactate metabolic process (GO:0006089)2.61581358
82axoneme assembly (GO:0035082)2.57849166
83centriole replication (GO:0007099)2.50560847
84negative regulation of organelle assembly (GO:1902116)2.47291859
85regulation of cilium assembly (GO:1902017)2.46627372
86RNA localization (GO:0006403)2.42493890
87nucleosome disassembly (GO:0006337)2.41513623
88protein-DNA complex disassembly (GO:0032986)2.41513623
89cell wall macromolecule catabolic process (GO:0016998)15.1832260
90cell wall macromolecule metabolic process (GO:0044036)15.1832260
91sperm motility (GO:0030317)13.8837443
92fusion of sperm to egg plasma membrane (GO:0007342)13.8401751
93acrosome reaction (GO:0007340)11.9230900
94acrosome assembly (GO:0001675)11.8437938
95sperm-egg recognition (GO:0035036)11.7222142
96multicellular organism reproduction (GO:0032504)11.2692983
97binding of sperm to zona pellucida (GO:0007339)10.6510930
98plasma membrane fusion (GO:0045026)10.5484891
99cell-cell recognition (GO:0009988)10.5040866
100epithelial cilium movement (GO:0003351)10.4146946

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse9.23893169
2TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.94847816
3EZH2_22144423_ChIP-Seq_EOC_Human3.58587625
4GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.40823199
5BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.21836039
6STAT6_21828071_ChIP-Seq_BEAS2B_Human2.86812068
7PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.71884503
8FLI1_27457419_Chip-Seq_LIVER_Mouse2.37039998
9VDR_22108803_ChIP-Seq_LS180_Human2.32902241
10CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.32883504
11CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.08822559
12GATA1_26923725_Chip-Seq_HPCs_Mouse2.07284379
13EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human2.05311531
14PCGF2_27294783_Chip-Seq_ESCs_Mouse2.04628543
15KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.98425699
16ZNF274_21170338_ChIP-Seq_K562_Hela1.92521524
17CBX2_27304074_Chip-Seq_ESCs_Mouse1.78731761
18TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.76081184
19RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.72574719
20STAT1_17558387_ChIP-Seq_HELA_Human1.72252412
21ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.71121810
22MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.69868289
23GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.67410594
24ELK4_26923725_Chip-Seq_MESODERM_Mouse1.67202535
25KAP1_22055183_ChIP-Seq_ESCs_Mouse1.64634970
26KDM2B_26808549_Chip-Seq_REH_Human1.63557039
27TAL1_26923725_Chip-Seq_HPCs_Mouse1.59148351
28GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.58857013
29FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.56077807
30SOX2_22085726_ChIP-Seq_NPCs_Mouse1.55445743
31WDR5_24793694_ChIP-Seq_LNCAP_Human1.52970375
32GATA3_21867929_ChIP-Seq_CD8_Mouse1.52186050
33PCGF2_27294783_Chip-Seq_NPCs_Mouse1.50782414
34NFE2_27457419_Chip-Seq_LIVER_Mouse1.46632528
35TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.44346249
36CBP_20019798_ChIP-Seq_JUKART_Human1.43306926
37IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.43306926
38ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.40453121
39SUZ12_27294783_Chip-Seq_NPCs_Mouse1.40090477
40CTBP2_25329375_ChIP-Seq_LNCAP_Human1.38215640
41ZFP57_27257070_Chip-Seq_ESCs_Mouse1.35834046
42GATA3_21867929_ChIP-Seq_TH1_Mouse1.33860916
43PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.32545439
44REST_21632747_ChIP-Seq_MESCs_Mouse1.32244140
45TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.30661952
46LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.30093296
47P53_21459846_ChIP-Seq_SAOS-2_Human1.27496757
48FLI1_21867929_ChIP-Seq_TH2_Mouse1.27379707
49CRX_20693478_ChIP-Seq_RETINA_Mouse1.24468265
50SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.23650843
51FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.22587287
52NANOG_18555785_Chip-Seq_ESCs_Mouse1.22303170
53GF1_26923725_Chip-Seq_HPCs_Mouse1.20347194
54EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.17277064
55CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.16754165
56MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.16553570
57TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16220096
58POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.16220096
59CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.15674374
60OCT4_18555785_Chip-Seq_ESCs_Mouse1.15147432
61CMYC_18555785_Chip-Seq_ESCs_Mouse1.14193485
62P53_22387025_ChIP-Seq_ESCs_Mouse1.13764940
63MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.13733154
64RAD21_21589869_ChIP-Seq_MESCs_Mouse1.13309981
65RUNX1_26923725_Chip-Seq_HPCs_Mouse1.08798842
66PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.08084139
67SPI1_26923725_Chip-Seq_HPCs_Mouse1.07672223
68SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.07323457
69NFIB_24661679_ChIP-Seq_LUNG_Mouse1.06970739
70P300_18555785_Chip-Seq_ESCs_Mouse1.06753011
71CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse1.06366345
72TAF15_26573619_Chip-Seq_HEK293_Human1.06188758
73EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.05845222
74ESET_19884257_ChIP-Seq_ESCs_Mouse1.04097037
75KLF4_18555785_Chip-Seq_ESCs_Mouse1.03682209
76KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.03237782
77EZH2_27294783_Chip-Seq_NPCs_Mouse1.02878935
78SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.02706093
79OCT4_21477851_ChIP-Seq_ESCs_Mouse1.02665254
80PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.02423812
81EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.02222702
82EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.99110012
83ESRRB_18555785_Chip-Seq_ESCs_Mouse0.98555217
84GATA1_19941827_ChIP-Seq_MEL86_Mouse0.97704103
85SUZ12_18555785_Chip-Seq_ESCs_Mouse0.97259912
86ERG_20517297_ChIP-Seq_VCAP_Human0.97168052
87SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.97002588
88PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.96594638
89NFYB_21822215_ChIP-Seq_K562_Human0.95946670
90SOX9_26525672_Chip-Seq_HEART_Mouse0.95000663
91GF1B_26923725_Chip-Seq_HPCs_Mouse0.93579165
92RNF2_27304074_Chip-Seq_NSC_Mouse0.93526767
93STAT3_18555785_Chip-Seq_ESCs_Mouse0.93443387
94SOX2_18555785_Chip-Seq_ESCs_Mouse0.93361453
95PU1_27457419_Chip-Seq_LIVER_Mouse0.93198566
96RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.93100680
97YY1_22570637_ChIP-Seq_MALME-3M_Human0.92149471
98LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.91943204
99RARA_24833708_ChIP-Seq_LIVER_Mouse0.91897694
100RXRA_24833708_ChIP-Seq_LIVER_Mouse0.91589139

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive6.17819671
2MP0001929_abnormal_gametogenesis5.61710793
3MP0008877_abnormal_DNA_methylation3.94993394
4MP0002210_abnormal_sex_determination3.42566110
5MP0002161_abnormal_fertility/fecundity3.35856941
6MP0001145_abnormal_male_reproductive2.91743426
7MP0005670_abnormal_white_adipose2.67805353
8MP0000653_abnormal_sex_gland2.54086923
9MP0002653_abnormal_ependyma_morphology2.45932278
10MP0005410_abnormal_fertilization16.5639535
11MP0005623_abnormal_meninges_morphology1.51354704
12MP0002160_abnormal_reproductive_system1.49812343
13MP0004233_abnormal_muscle_weight1.44609750
14MP0002282_abnormal_trachea_morphology1.24939573
15MP0001984_abnormal_olfaction1.22124695
16MP0003646_muscle_fatigue1.20816261
17MP0001765_abnormal_ion_homeostasis1.18026436
18MP0008058_abnormal_DNA_repair1.12372945
19MP0002234_abnormal_pharynx_morphology0.94568588
20MP0005647_abnormal_sex_gland0.92975408
21MP0009046_muscle_twitch0.89412506
22MP0005389_reproductive_system_phenotype0.75089062
23MP0005377_hearing/vestibular/ear_phenot0.67897130
24MP0003878_abnormal_ear_physiology0.67897130
25MP0003011_delayed_dark_adaptation0.66611659
26MP0005636_abnormal_mineral_homeostasis0.64516833
27MP0008995_early_reproductive_senescence0.61890293
28MP0003115_abnormal_respiratory_system0.60142409
29MP0002102_abnormal_ear_morphology0.58650266
30MP0002928_abnormal_bile_duct0.58297072
31MP0001324_abnormal_eye_pigmentation0.54951215
32MP0005666_abnormal_adipose_tissue0.50242497
33MP0002736_abnormal_nociception_after0.49885307
34MP0004019_abnormal_vitamin_homeostasis0.49720281
35MP0010094_abnormal_chromosome_stability0.49061015
36MP0005551_abnormal_eye_electrophysiolog0.48327923
37MP0000358_abnormal_cell_content/0.47481054
38MP0003699_abnormal_female_reproductive0.45852190
39MP0004036_abnormal_muscle_relaxation0.44704319
40MP0001764_abnormal_homeostasis0.44059927
41MP0005253_abnormal_eye_physiology0.42531310
42MP0001293_anophthalmia0.42370625
43MP0002269_muscular_atrophy0.41073908
44MP0000569_abnormal_digit_pigmentation0.39510165
45MP0003329_amyloid_beta_deposits0.37512362
46MP0006036_abnormal_mitochondrial_physio0.35494440
47MP0009115_abnormal_fat_cell0.35387080
48MP0002971_abnormal_brown_adipose0.34713433
49MP0003950_abnormal_plasma_membrane0.32359700
50MP0005391_vision/eye_phenotype0.32299316
51MP0001119_abnormal_female_reproductive0.30993188
52MP0000534_abnormal_ureter_morphology0.29753577
53MP0004133_heterotaxia0.29733669
54MP0001968_abnormal_touch/_nociception0.29699698
55MP0003633_abnormal_nervous_system0.29447765
56MP0008875_abnormal_xenobiotic_pharmacok0.29030515
57MP0005397_hematopoietic_system_phenotyp0.27848222
58MP0001545_abnormal_hematopoietic_system0.27848222
59MP0004811_abnormal_neuron_physiology0.25395177
60MP0002796_impaired_skin_barrier0.25301943
61MP0002139_abnormal_hepatobiliary_system0.25168125
62MP0002132_abnormal_respiratory_system0.24936234
63MP0003942_abnormal_urinary_system0.24718679
64MP0006035_abnormal_mitochondrial_morpho0.24545739
65MP0003111_abnormal_nucleus_morphology0.23853286
66MP0003786_premature_aging0.22321591
67MP0003879_abnormal_hair_cell0.22261431
68MP0001986_abnormal_taste_sensitivity0.21276966
69MP0010307_abnormal_tumor_latency0.21251549
70MP0003861_abnormal_nervous_system0.20917938
71MP0009278_abnormal_bone_marrow0.20457476
72MP0002693_abnormal_pancreas_physiology0.20377100
73MP0002169_no_abnormal_phenotype0.19924062
74MP0002873_normal_phenotype0.19708114
75MP0001849_ear_inflammation0.19619848
76MP0003631_nervous_system_phenotype0.19300224
77MP0002152_abnormal_brain_morphology0.19262517
78MP0005365_abnormal_bile_salt0.18999453
79MP0000604_amyloidosis0.17783252
80MP0004742_abnormal_vestibular_system0.17660581
81MP0005319_abnormal_enzyme/_coenzyme0.17507318
82MP0002092_abnormal_eye_morphology0.16825448
83MP0003959_abnormal_lean_body0.16748292
84MP0009672_abnormal_birth_weight0.16722236
85MP0006072_abnormal_retinal_apoptosis0.16520301
86MP0002295_abnormal_pulmonary_circulatio0.15942115
87MP0003948_abnormal_gas_homeostasis0.15843297
88MP0002229_neurodegeneration0.14894744
89MP0002405_respiratory_system_inflammati0.14827815
90MP0004145_abnormal_muscle_electrophysio0.14766654
91MP0008569_lethality_at_weaning0.14348983
92MP0000313_abnormal_cell_death0.14236742
93MP0005195_abnormal_posterior_eye0.13791569
94MP0001730_embryonic_growth_arrest0.13511129
95MP0000462_abnormal_digestive_system0.13126496
96MP0002118_abnormal_lipid_homeostasis0.12909263
97MP0009250_abnormal_appendicular_skeleto0.12586285
98MP0010329_abnormal_lipoprotein_level0.12555109
99MP0000001_mammalian_phenotype0.12095098
100MP0008057_abnormal_DNA_replication0.11099155

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)9.39942427
2Abnormal respiratory motile cilium morphology (HP:0005938)9.39046201
3Abnormal respiratory epithelium morphology (HP:0012253)9.39046201
4Rhinitis (HP:0012384)7.58505986
5Abnormal ciliary motility (HP:0012262)7.53747144
6Chronic bronchitis (HP:0004469)7.51853152
7Infertility (HP:0000789)6.64615834
8Nasal polyposis (HP:0100582)6.38981486
9Abnormality of the nasal mucosa (HP:0000433)5.24331441
10Bronchitis (HP:0012387)4.60858677
11Bronchiectasis (HP:0002110)4.46724955
12Male infertility (HP:0003251)4.36034031
13Nephronophthisis (HP:0000090)4.08178079
14Recurrent sinusitis (HP:0011108)3.47446685
15Abnormal spermatogenesis (HP:0008669)3.39251409
16Recurrent otitis media (HP:0000403)3.29831476
17Abnormality of the renal medulla (HP:0100957)3.13080847
18Tubulointerstitial nephritis (HP:0001970)2.92957175
19Medial flaring of the eyebrow (HP:0010747)2.68103481
20Recurrent bronchitis (HP:0002837)2.66862360
21Molar tooth sign on MRI (HP:0002419)2.58431965
22Abnormality of midbrain morphology (HP:0002418)2.58431965
23Impulsivity (HP:0100710)2.44032058
24Tubular atrophy (HP:0000092)2.42524116
25Tubulointerstitial abnormality (HP:0001969)2.31187304
26Azoospermia (HP:0000027)2.21529624
27Cholecystitis (HP:0001082)2.17340387
28Abnormal gallbladder physiology (HP:0012438)2.17340387
29Gonadotropin excess (HP:0000837)2.11753081
30Dynein arm defect of respiratory motile cilia (HP:0012255)13.5582437
31Absent/shortened dynein arms (HP:0200106)13.5582437
32Respiratory insufficiency due to defective ciliary clearance (HP:0200073)13.2972150
33Dyschromatopsia (HP:0007641)1.93700698
34Decreased central vision (HP:0007663)1.86024802
35Postaxial foot polydactyly (HP:0001830)1.81035591
36Stage 5 chronic kidney disease (HP:0003774)1.74441006
37Spastic tetraparesis (HP:0001285)1.73626230
38Tubulointerstitial fibrosis (HP:0005576)1.71637714
39Asymmetric septal hypertrophy (HP:0001670)1.71242004
40Congenital hepatic fibrosis (HP:0002612)1.68644717
41Gait imbalance (HP:0002141)1.65191633
42Congenital primary aphakia (HP:0007707)1.65106434
43Abnormality of the renal cortex (HP:0011035)1.63793862
44Heterotopia (HP:0002282)1.61860229
45Abnormality of permanent molar morphology (HP:0011071)1.60878017
46Abnormality of the dental root (HP:0006486)1.60878017
47Taurodontia (HP:0000679)1.60878017
48Abnormality of renal excretion (HP:0011036)1.58874267
49Choroideremia (HP:0001139)1.58289138
50Hypoplasia of the capital femoral epiphysis (HP:0003090)1.57818188
51Chronic sinusitis (HP:0011109)1.57525568
52Polydipsia (HP:0001959)1.57287247
53Abnormal drinking behavior (HP:0030082)1.57287247
54Aplasia/Hypoplasia of the lens (HP:0008063)1.56823476
55Abnormal biliary tract physiology (HP:0012439)1.56784039
56Bile duct proliferation (HP:0001408)1.56784039
57Short ribs (HP:0000773)1.55195351
58Bundle branch block (HP:0011710)1.52800857
59Abnormality of molar (HP:0011077)1.50981265
60Abnormality of molar morphology (HP:0011070)1.50981265
61Abnormality of the dental pulp (HP:0006479)1.48294637
62Fibular hypoplasia (HP:0003038)1.48148878
63Postaxial hand polydactyly (HP:0001162)1.47791691
64Renal dysplasia (HP:0000110)1.46881066
65Oculomotor apraxia (HP:0000657)1.46703833
66Bell-shaped thorax (HP:0001591)1.46433864
67Hemorrhage of the eye (HP:0011885)1.44471370
68Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.43222898
69Double outlet right ventricle (HP:0001719)1.42081174
70Congenital malformation of the right heart (HP:0011723)1.42081174
71Nephrogenic diabetes insipidus (HP:0009806)1.41650920
72Facial cleft (HP:0002006)1.38674502
73Cystic liver disease (HP:0006706)1.37489652
74Deformed sella turcica (HP:0002681)1.35313883
75Abnormality of dentin (HP:0010299)1.34844922
76Optic nerve hypoplasia (HP:0000609)1.34652107
77Abnormality of saccadic eye movements (HP:0000570)1.32200120
78Pancreatic fibrosis (HP:0100732)1.32135196
79Constricted visual fields (HP:0001133)1.31610304
80Vaginal atresia (HP:0000148)1.30708659
81Abnormality of the lower motor neuron (HP:0002366)1.28829472
82Genital tract atresia (HP:0001827)1.28808996
83Easy fatigability (HP:0003388)1.27697857
84Decreased electroretinogram (ERG) amplitude (HP:0000654)1.25856293
85Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.25464734
86Absent epiphyses (HP:0010577)1.25464734
87Sensory axonal neuropathy (HP:0003390)1.25338702
88Abnormality of the neuromuscular junction (HP:0003398)1.24317537
89Fatigable weakness (HP:0003473)1.24317537
90Cerebellar dysplasia (HP:0007033)1.24288257
91Abnormality of ocular smooth pursuit (HP:0000617)1.24186319
92Neurofibrillary tangles (HP:0002185)1.23513337
93Poor coordination (HP:0002370)1.21817182
94Vascular calcification (HP:0004934)1.20821692
95Aplasia/Hypoplasia of the tongue (HP:0010295)1.20539780
96Abnormal urine output (HP:0012590)1.19781680
97True hermaphroditism (HP:0010459)1.19409598
98Nephropathy (HP:0000112)1.16958902
99J-shaped sella turcica (HP:0002680)1.15699104
100Absent frontal sinuses (HP:0002688)1.14684481

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK39.11982404
2PDK49.11982404
3PDK25.92140147
4TESK15.37134388
5PRKD34.09711726
6ICK3.69415246
7PTK2B1.93454540
8WNK41.85171284
9STK391.78560106
10PNCK1.64011918
11STK381.57295699
12DYRK1B1.34899566
13NEK21.32974573
14PDK11.15117494
15IRAK10.97297056
16LMTK20.75835148
17DYRK30.75097356
18TYRO30.74019889
19MAP2K60.72409925
20MAPK150.70499903
21WNK10.64171801
22PASK0.64039273
23RIPK40.63173097
24PDPK10.61000055
25CCNB10.58610799
26STK30.54545661
27CHEK20.54228614
28EEF2K0.52658401
29IRAK20.52402034
30TTK0.49001671
31CAMK1G0.45719581
32NTRK20.43856759
33STK38L0.42462374
34TESK20.42233424
35PINK10.40962291
36PLK40.39210740
37MUSK0.37696864
38CHEK10.34347817
39MAPKAPK50.31534420
40PAK10.31042645
41PRKCG0.29308969
42ATM0.23332953
43PAK20.22867412
44NEK60.22489150
45WEE10.21327394
46MARK20.21174393
47MAP3K100.20583131
48CAMKK10.20082978
49ATR0.18367582
50MTOR0.18317870
51BRSK20.18174309
52PRKCZ0.16164115
53PRKAA10.15059911
54STK110.14249303
55PRKG20.14026558
56PKN10.13808076
57PAK40.12910832
58PRKCQ0.12696461
59RPS6KB10.10259511
60CDK150.09938546
61PLK10.09589306
62CDC70.09212703
63MAP3K50.07780476
64CDK180.07572974
65CDK120.06876245
66CDK11A0.06400139
67RPS6KA10.06040003
68MARK30.05860586
69PRKG10.05708106
70CSNK2A10.05602004
71YES10.05587847
72PRKACG0.05396280
73GSK3B0.04827033
74BRSK10.03964002
75CAMK2A0.03518000
76CDK140.03382553
77CSNK2A20.02785963
78CDK60.02662854
79CSNK1D0.02338241
80RIPK10.02051940
81PRKCD0.01303701
82PRKCA0.01121549
83MAPK80.01118819
84PDGFRB0.01116354
85CDK10.00899729
86STK100.00889682
87PRKACB0.00750673
88CDK20.00537132
89PRKCB0.00496838
90WNK30.00281515
91PIM10.00016003
92CAMK1-0.0314523
93BRAF-0.0301689
94GSK3A-0.0252707
95RPS6KA3-0.0242902
96PRKACA-0.0240876
97MAP3K1-0.0168206
98CSF1R-0.0089392
99EGFR-0.0069657
100ZAP70-0.0042181

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycolysis / Gluconeogenesis_Homo sapiens_hsa000104.56349771
2Fatty acid biosynthesis_Homo sapiens_hsa000614.18420342
3Vitamin B6 metabolism_Homo sapiens_hsa007503.54378129
4Pyruvate metabolism_Homo sapiens_hsa006203.51901768
5alpha-Linolenic acid metabolism_Homo sapiens_hsa005923.00154940
6Linoleic acid metabolism_Homo sapiens_hsa005912.94807066
7Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.68056782
8Propanoate metabolism_Homo sapiens_hsa006402.63196896
9Glucagon signaling pathway_Homo sapiens_hsa049222.59120977
10Carbohydrate digestion and absorption_Homo sapiens_hsa049732.30925416
11Basal transcription factors_Homo sapiens_hsa030222.25610273
12Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.11732457
13Glycosaminoglycan degradation_Homo sapiens_hsa005312.07243993
14Glycerolipid metabolism_Homo sapiens_hsa005612.04512972
15Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005122.02806922
16Selenocompound metabolism_Homo sapiens_hsa004501.97420059
17Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.86435814
18PPAR signaling pathway_Homo sapiens_hsa033201.81579925
19Pentose phosphate pathway_Homo sapiens_hsa000301.70107749
20Oocyte meiosis_Homo sapiens_hsa041141.69686161
21Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.65790323
22Glycerophospholipid metabolism_Homo sapiens_hsa005641.61495772
23Mineral absorption_Homo sapiens_hsa049781.60764271
24Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.55636688
25Fructose and mannose metabolism_Homo sapiens_hsa000511.49927286
26Amphetamine addiction_Homo sapiens_hsa050311.39361978
27Fat digestion and absorption_Homo sapiens_hsa049751.39353074
28Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.37301132
29Ether lipid metabolism_Homo sapiens_hsa005651.37284313
30Carbon metabolism_Homo sapiens_hsa012001.35967063
31Dorso-ventral axis formation_Homo sapiens_hsa043201.33596781
32Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.31637668
33Collecting duct acid secretion_Homo sapiens_hsa049661.28255092
34Cardiac muscle contraction_Homo sapiens_hsa042601.27522856
35Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.24799802
36Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.22783882
37Fatty acid degradation_Homo sapiens_hsa000711.19874719
38Fanconi anemia pathway_Homo sapiens_hsa034601.19370988
39Fatty acid metabolism_Homo sapiens_hsa012121.17443921
40Glutathione metabolism_Homo sapiens_hsa004801.16108153
41Cysteine and methionine metabolism_Homo sapiens_hsa002701.08135200
42Chemical carcinogenesis_Homo sapiens_hsa052041.06903772
43Antigen processing and presentation_Homo sapiens_hsa046121.03916979
44Renin secretion_Homo sapiens_hsa049241.03142633
45Purine metabolism_Homo sapiens_hsa002301.01791499
46Huntingtons disease_Homo sapiens_hsa050161.01602388
47Hedgehog signaling pathway_Homo sapiens_hsa043400.86238583
48Biosynthesis of amino acids_Homo sapiens_hsa012300.82220840
49mRNA surveillance pathway_Homo sapiens_hsa030150.81483008
50Arachidonic acid metabolism_Homo sapiens_hsa005900.79699068
51Insulin secretion_Homo sapiens_hsa049110.78930584
52Bile secretion_Homo sapiens_hsa049760.75578778
53Sulfur metabolism_Homo sapiens_hsa009200.69827023
54Pentose and glucuronate interconversions_Homo sapiens_hsa000400.69192638
55Adipocytokine signaling pathway_Homo sapiens_hsa049200.68555808
56Thyroid hormone synthesis_Homo sapiens_hsa049180.68127183
57Estrogen signaling pathway_Homo sapiens_hsa049150.64886878
58Inositol phosphate metabolism_Homo sapiens_hsa005620.63606238
59Central carbon metabolism in cancer_Homo sapiens_hsa052300.61523252
60cGMP-PKG signaling pathway_Homo sapiens_hsa040220.60786847
61Systemic lupus erythematosus_Homo sapiens_hsa053220.60686666
62RNA transport_Homo sapiens_hsa030130.60536870
63Synaptic vesicle cycle_Homo sapiens_hsa047210.60170163
64Renin-angiotensin system_Homo sapiens_hsa046140.60006836
65Long-term potentiation_Homo sapiens_hsa047200.58869324
66Calcium signaling pathway_Homo sapiens_hsa040200.55633980
67Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.55099025
68Pancreatic secretion_Homo sapiens_hsa049720.54572853
69Phosphatidylinositol signaling system_Homo sapiens_hsa040700.54305961
70ABC transporters_Homo sapiens_hsa020100.54249199
71Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.52762652
72Protein digestion and absorption_Homo sapiens_hsa049740.52342036
73Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.51985337
74Legionellosis_Homo sapiens_hsa051340.51761744
75Salivary secretion_Homo sapiens_hsa049700.49153212
76Thyroid hormone signaling pathway_Homo sapiens_hsa049190.48273777
77Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.48191307
78Gastric acid secretion_Homo sapiens_hsa049710.45702845
79Taste transduction_Homo sapiens_hsa047420.41669363
80Metabolic pathways_Homo sapiens_hsa011000.41636567
81Endocytosis_Homo sapiens_hsa041440.38198133
82AMPK signaling pathway_Homo sapiens_hsa041520.37354469
83Vascular smooth muscle contraction_Homo sapiens_hsa042700.35258142
84Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.33390492
85cAMP signaling pathway_Homo sapiens_hsa040240.32408298
86VEGF signaling pathway_Homo sapiens_hsa043700.29637852
87Circadian entrainment_Homo sapiens_hsa047130.27090434
88Alcoholism_Homo sapiens_hsa050340.23332101
89Pyrimidine metabolism_Homo sapiens_hsa002400.21379417
90Retinol metabolism_Homo sapiens_hsa008300.20506404
91Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.17964263
92Cocaine addiction_Homo sapiens_hsa050300.15014584
93N-Glycan biosynthesis_Homo sapiens_hsa005100.13318456
94Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.12951279
95Basal cell carcinoma_Homo sapiens_hsa052170.10710846
96Wnt signaling pathway_Homo sapiens_hsa043100.10508980
97Steroid hormone biosynthesis_Homo sapiens_hsa001400.09521965
98B cell receptor signaling pathway_Homo sapiens_hsa046620.06968448
99Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.05561716
100HIF-1 signaling pathway_Homo sapiens_hsa040660.04809439

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