TEX30

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synapsis (GO:0007129)6.12828786
2attachment of spindle microtubules to kinetochore (GO:0008608)6.09888842
3chromatin remodeling at centromere (GO:0031055)5.12309235
4CENP-A containing nucleosome assembly (GO:0034080)5.11574794
5telomere maintenance via semi-conservative replication (GO:0032201)5.02724741
6DNA strand elongation involved in DNA replication (GO:0006271)4.93608112
7male meiosis I (GO:0007141)4.84785975
8telomere maintenance via recombination (GO:0000722)4.76559379
9DNA strand elongation (GO:0022616)4.70493865
10DNA replication initiation (GO:0006270)4.55959107
11DNA replication-independent nucleosome assembly (GO:0006336)4.53012671
12DNA replication-independent nucleosome organization (GO:0034724)4.53012671
13mitotic recombination (GO:0006312)4.52454641
14DNA replication checkpoint (GO:0000076)4.47535211
15kinetochore organization (GO:0051383)4.42726852
16chromosome organization involved in meiosis (GO:0070192)4.37129110
17DNA deamination (GO:0045006)4.30199086
18meiosis I (GO:0007127)4.29112635
19histone exchange (GO:0043486)4.27748103
20viral mRNA export from host cell nucleus (GO:0046784)4.17741165
21meiotic chromosome segregation (GO:0045132)4.16276430
22negative regulation of ubiquitin-protein transferase activity (GO:0051444)4.11955939
23negative regulation of ligase activity (GO:0051352)4.11955939
24kinetochore assembly (GO:0051382)4.06644390
25ribosomal small subunit assembly (GO:0000028)4.06041920
26DNA replication-dependent nucleosome organization (GO:0034723)4.04483227
27DNA replication-dependent nucleosome assembly (GO:0006335)4.04483227
28mitotic metaphase plate congression (GO:0007080)3.97628841
29mitotic sister chromatid segregation (GO:0000070)3.94063886
30DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.92146753
31regulation of cellular amino acid metabolic process (GO:0006521)3.91094480
32telomere maintenance via telomere lengthening (GO:0010833)3.87453466
33signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.86713231
34signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.86713231
35signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.86713231
36establishment of protein localization to mitochondrial membrane (GO:0090151)3.86361419
37signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.85861473
38intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.85861473
39nucleotide-excision repair, DNA gap filling (GO:0006297)3.85482930
40mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.85088162
41positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.76949644
42protein localization to kinetochore (GO:0034501)3.76093678
43signal transduction involved in DNA integrity checkpoint (GO:0072401)3.72520328
44signal transduction involved in DNA damage checkpoint (GO:0072422)3.72520328
45male meiosis (GO:0007140)3.69352677
46piRNA metabolic process (GO:0034587)3.67409005
47metaphase plate congression (GO:0051310)3.66961120
48signal transduction involved in cell cycle checkpoint (GO:0072395)3.66800656
49positive regulation of ligase activity (GO:0051351)3.64241732
50DNA catabolic process, exonucleolytic (GO:0000738)3.55510978
51sister chromatid segregation (GO:0000819)3.55302155
52mitotic chromosome condensation (GO:0007076)3.53973855
53meiotic nuclear division (GO:0007126)3.53758511
54nucleobase biosynthetic process (GO:0046112)3.53582660
55chaperone-mediated protein transport (GO:0072321)3.52437874
56protein localization to chromosome, centromeric region (GO:0071459)3.50784474
57maturation of SSU-rRNA (GO:0030490)3.50032623
58protein complex biogenesis (GO:0070271)3.48785208
59DNA unwinding involved in DNA replication (GO:0006268)3.45553339
60establishment of integrated proviral latency (GO:0075713)3.39882487
61proteasome assembly (GO:0043248)3.38887466
62deoxyribonucleotide biosynthetic process (GO:0009263)3.38571211
63establishment of chromosome localization (GO:0051303)3.38244341
64protein neddylation (GO:0045116)3.37963022
65regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.37922863
66DNA ligation (GO:0006266)3.37329656
67formation of translation preinitiation complex (GO:0001731)3.37272549
68mitotic nuclear envelope disassembly (GO:0007077)3.36755517
69purine nucleobase biosynthetic process (GO:0009113)3.35776040
70regulation of nuclear cell cycle DNA replication (GO:0033262)3.34968532
71mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.34048990
72mitochondrial respiratory chain complex I assembly (GO:0032981)3.34048990
73NADH dehydrogenase complex assembly (GO:0010257)3.34048990
74regulation of ubiquitin-protein transferase activity (GO:0051438)3.33879200
75mitochondrial respiratory chain complex assembly (GO:0033108)3.33329841
76transcription-coupled nucleotide-excision repair (GO:0006283)3.31606033
77mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.29369124
78ATP synthesis coupled proton transport (GO:0015986)3.29182834
79energy coupled proton transport, down electrochemical gradient (GO:0015985)3.29182834
80tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.28322290
81RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.28322290
82regulation of ligase activity (GO:0051340)3.25084174
83respiratory chain complex IV assembly (GO:0008535)3.24948243
84regulation of double-strand break repair via homologous recombination (GO:0010569)3.23831118
85rRNA modification (GO:0000154)3.23558926
86regulation of mitochondrial translation (GO:0070129)3.21815437
87deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.19047838
88DNA synthesis involved in DNA repair (GO:0000731)3.18344758
89chromosome segregation (GO:0007059)3.17611770
90chromatin assembly or disassembly (GO:0006333)3.16046438
91DNA double-strand break processing (GO:0000729)3.14971969
92maturation of 5.8S rRNA (GO:0000460)3.14192686
93regulation of meiosis I (GO:0060631)3.12426479
94protein K6-linked ubiquitination (GO:0085020)3.11547496
95mitotic spindle checkpoint (GO:0071174)3.11417222
96meiotic cell cycle process (GO:1903046)3.11158067
97replication fork processing (GO:0031297)3.10909655
98telomere maintenance (GO:0000723)3.10882819
99histone H2A acetylation (GO:0043968)3.10653709
100telomere organization (GO:0032200)3.10388620
101pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.10204478
102ATP-dependent chromatin remodeling (GO:0043044)3.09751737
103sister chromatid cohesion (GO:0007062)3.09715464
104nuclear envelope disassembly (GO:0051081)3.09254786
105membrane disassembly (GO:0030397)3.09254786
106spliceosomal snRNP assembly (GO:0000387)3.07370614
107DNA damage response, signal transduction by p53 class mediator (GO:0030330)3.05822661
108pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.04514167
109regulation of centriole replication (GO:0046599)3.04463010
110nuclear pore organization (GO:0006999)3.04048802
111establishment of viral latency (GO:0019043)3.03853284
112ribosomal large subunit biogenesis (GO:0042273)3.03669116
113synaptonemal complex assembly (GO:0007130)3.03337279
114negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.02662195
115rRNA processing (GO:0006364)3.02661561
116ribosome biogenesis (GO:0042254)3.02579933
117IMP biosynthetic process (GO:0006188)3.02493917
118cell cycle G1/S phase transition (GO:0044843)3.01461433
119G1/S transition of mitotic cell cycle (GO:0000082)3.01461433
120nuclear pore complex assembly (GO:0051292)3.01328680
121antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.00603114
122exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.99782107
123DNA methylation involved in gamete generation (GO:0043046)2.99632235
124termination of RNA polymerase II transcription (GO:0006369)2.99356722
125cytochrome complex assembly (GO:0017004)2.99226513
126mitotic spindle assembly checkpoint (GO:0007094)2.98951783
127regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.98739710
128positive regulation of cell cycle arrest (GO:0071158)2.97682948
129anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.97303410
130ribonucleoprotein complex biogenesis (GO:0022613)2.96611959
131negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.95177825
132cullin deneddylation (GO:0010388)2.93885647
133protein deneddylation (GO:0000338)2.93652722
134mismatch repair (GO:0006298)2.92906956
135pseudouridine synthesis (GO:0001522)2.92293449
136rRNA metabolic process (GO:0016072)2.90672116
137nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.89216959
138resolution of meiotic recombination intermediates (GO:0000712)2.88206950
139mitotic cell cycle (GO:0000278)2.88179989
140maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.87280612
141rRNA methylation (GO:0031167)2.86174240
142positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.86042132
143regulation of mitotic metaphase/anaphase transition (GO:0030071)2.85272963
144negative regulation of mitotic sister chromatid separation (GO:2000816)2.84736395
145negative regulation of mitotic sister chromatid segregation (GO:0033048)2.84736395
146negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.84736395
147negative regulation of sister chromatid segregation (GO:0033046)2.84736395
148spindle checkpoint (GO:0031577)2.84188754
1497-methylguanosine mRNA capping (GO:0006370)2.83888060
150protein localization to chromosome (GO:0034502)2.83126623
151ribosomal small subunit biogenesis (GO:0042274)2.83100676
152synaptonemal complex organization (GO:0070193)2.82395516
153regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.81333624
154RNA capping (GO:0036260)2.80652072
1557-methylguanosine RNA capping (GO:0009452)2.80652072

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.45676340
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.12198918
3E2F4_17652178_ChIP-ChIP_JURKAT_Human4.10522448
4FOXM1_23109430_ChIP-Seq_U2OS_Human3.96375333
5MYC_18555785_ChIP-Seq_MESCs_Mouse3.94149612
6FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.53848884
7EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.30496259
8EST1_17652178_ChIP-ChIP_JURKAT_Human3.18278450
9GABP_17652178_ChIP-ChIP_JURKAT_Human3.08083311
10JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.00894858
11CREB1_15753290_ChIP-ChIP_HEK293T_Human2.82469678
12MYC_19030024_ChIP-ChIP_MESCs_Mouse2.69976938
13MYC_18358816_ChIP-ChIP_MESCs_Mouse2.69767701
14ETS1_20019798_ChIP-Seq_JURKAT_Human2.67746121
15HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.60515183
16ELF1_17652178_ChIP-ChIP_JURKAT_Human2.59540102
17MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.52673238
18MYC_19079543_ChIP-ChIP_MESCs_Mouse2.44009034
19AR_21909140_ChIP-Seq_LNCAP_Human2.42486577
20VDR_23849224_ChIP-Seq_CD4+_Human2.41346954
21CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.36100835
22E2F1_21310950_ChIP-Seq_MCF-7_Human2.32242113
23HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.26622860
24NELFA_20434984_ChIP-Seq_ESCs_Mouse2.25953227
25NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.18107206
26DCP1A_22483619_ChIP-Seq_HELA_Human2.17875768
27FOXP3_21729870_ChIP-Seq_TREG_Human2.12192333
28HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.10174044
29XRN2_22483619_ChIP-Seq_HELA_Human2.08902282
30PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.06021427
31ELK1_19687146_ChIP-ChIP_HELA_Human2.03449252
32FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.98045639
33MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.96528957
34MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.94890841
35E2F1_18555785_ChIP-Seq_MESCs_Mouse1.93923761
36SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.93769130
37MYCN_18555785_ChIP-Seq_MESCs_Mouse1.82637090
38TTF2_22483619_ChIP-Seq_HELA_Human1.80958470
39GABP_19822575_ChIP-Seq_HepG2_Human1.79714494
40THAP11_20581084_ChIP-Seq_MESCs_Mouse1.79683826
41HOXB4_20404135_ChIP-ChIP_EML_Mouse1.77498092
42SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.75288175
43SRF_21415370_ChIP-Seq_HL-1_Mouse1.69758143
44KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.67166251
45TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.62494934
46YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.60555262
47TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.56452235
48POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.52332639
49CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.50423244
50YY1_21170310_ChIP-Seq_MESCs_Mouse1.47193251
51FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.46455978
52ERG_20887958_ChIP-Seq_HPC-7_Mouse1.46451405
53ZFX_18555785_ChIP-Seq_MESCs_Mouse1.45405888
54CIITA_25753668_ChIP-Seq_RAJI_Human1.43245315
55RBPJ_22232070_ChIP-Seq_NCS_Mouse1.42293495
56SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.41775919
57NOTCH1_21737748_ChIP-Seq_TLL_Human1.37998382
58PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.35614846
59PADI4_21655091_ChIP-ChIP_MCF-7_Human1.33719011
60ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.33578902
61* ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.33319356
62MYC_18940864_ChIP-ChIP_HL60_Human1.27353863
63NANOG_18555785_ChIP-Seq_MESCs_Mouse1.26640047
64SALL1_21062744_ChIP-ChIP_HESCs_Human1.26134884
65E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.21790125
66KDM5A_27292631_Chip-Seq_BREAST_Human1.20335998
67EWS_26573619_Chip-Seq_HEK293_Human1.19920920
68EGR1_19374776_ChIP-ChIP_THP-1_Human1.19027649
69ZNF274_21170338_ChIP-Seq_K562_Hela1.16416621
70SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.16186702
71FLI1_27457419_Chip-Seq_LIVER_Mouse1.15057283
72E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.11843594
73IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.09493636
74CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.09036006
75FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.08324556
76CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.07978053
77VDR_22108803_ChIP-Seq_LS180_Human1.06415967
78ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.06120403
79POU3F2_20337985_ChIP-ChIP_501MEL_Human1.04268157
80HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.04131866
81* SPI1_23547873_ChIP-Seq_NB4_Human1.02601031
82CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.02109987
83GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.00840268
84FUS_26573619_Chip-Seq_HEK293_Human1.00241153
85HTT_18923047_ChIP-ChIP_STHdh_Human0.99386953
86POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.96315053
87KLF4_18555785_ChIP-Seq_MESCs_Mouse0.92892514
88IGF1R_20145208_ChIP-Seq_DFB_Human0.88565322
89TFEB_21752829_ChIP-Seq_HELA_Human0.88447759
90TP53_22573176_ChIP-Seq_HFKS_Human0.88228955
91EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.87306074
92ELK1_22589737_ChIP-Seq_MCF10A_Human0.86916777
93BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.84975249
94MYC_22102868_ChIP-Seq_BL_Human0.84275772
95TP63_19390658_ChIP-ChIP_HaCaT_Human0.83840649
96CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.83707298
97SOX2_18555785_ChIP-Seq_MESCs_Mouse0.83322709
98CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.83277014
99CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.80966234
100FOXA1_27270436_Chip-Seq_PROSTATE_Human0.80370655
101FOXA1_25329375_ChIP-Seq_VCAP_Human0.80370655
102PCGF2_27294783_Chip-Seq_ESCs_Mouse0.79085496
103BP1_19119308_ChIP-ChIP_Hs578T_Human0.78663532
104RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.77897641
105PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.77336841
106GATA1_22025678_ChIP-Seq_K562_Human0.77021992
107KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.74841267
108STAT3_1855785_ChIP-Seq_MESCs_Mouse0.72183573
109CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.71786155
110HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.71409589
111DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.70828150
112POU5F1_16153702_ChIP-ChIP_HESCs_Human0.70297257
113PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.70146802
114FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.69336954
115CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.68625674
116STAT4_19710469_ChIP-ChIP_TH1__Mouse0.67720502
117SOX17_20123909_ChIP-Seq_XEN_Mouse0.67533391
118IRF1_19129219_ChIP-ChIP_H3396_Human0.65340815
119DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.65326838
120AR_20517297_ChIP-Seq_VCAP_Human0.65016524
121CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.64951802
122TBX5_21415370_ChIP-Seq_HL-1_Mouse0.63579964
123MYB_26560356_Chip-Seq_TH2_Human0.61705708

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability4.85080473
2MP0003693_abnormal_embryo_hatching4.84221666
3MP0008057_abnormal_DNA_replication4.25067316
4MP0008877_abnormal_DNA_methylation4.23004947
5MP0003111_abnormal_nucleus_morphology4.13482821
6MP0008058_abnormal_DNA_repair4.04401379
7MP0004957_abnormal_blastocyst_morpholog3.93787216
8MP0003077_abnormal_cell_cycle3.92988432
9MP0008007_abnormal_cellular_replicative3.37555292
10MP0003786_premature_aging2.88274646
11MP0008932_abnormal_embryonic_tissue2.56523833
12MP0000372_irregular_coat_pigmentation2.56266989
13MP0002396_abnormal_hematopoietic_system2.44666900
14MP0003123_paternal_imprinting2.29916145
15MP0002210_abnormal_sex_determination2.05879722
16MP0001929_abnormal_gametogenesis1.84893082
17MP0003806_abnormal_nucleotide_metabolis1.83261799
18MP0005084_abnormal_gallbladder_morpholo1.77558129
19MP0008995_early_reproductive_senescence1.75822547
20MP0004808_abnormal_hematopoietic_stem1.72599152
21MP0001145_abnormal_male_reproductive1.71946073
22MP0000350_abnormal_cell_proliferation1.70785382
23MP0000490_abnormal_crypts_of1.62649972
24MP0006054_spinal_hemorrhage1.62316410
25MP0006035_abnormal_mitochondrial_morpho1.61081760
26MP0000653_abnormal_sex_gland1.59287853
27MP0003763_abnormal_thymus_physiology1.57632323
28MP0001730_embryonic_growth_arrest1.56106854
29MP0003718_maternal_effect1.54184508
30MP0006072_abnormal_retinal_apoptosis1.51544062
31MP0010307_abnormal_tumor_latency1.42527860
32MP0002019_abnormal_tumor_incidence1.39669973
33MP0003195_calcinosis1.39150988
34MP0005397_hematopoietic_system_phenotyp1.37616141
35MP0001545_abnormal_hematopoietic_system1.37616141
36MP0009333_abnormal_splenocyte_physiolog1.36110291
37MP0000313_abnormal_cell_death1.34807390
38MP0001119_abnormal_female_reproductive1.33689087
39MP0009697_abnormal_copulation1.32721045
40MP0006292_abnormal_olfactory_placode1.32291567
41MP0000358_abnormal_cell_content/1.31615071
42MP0002160_abnormal_reproductive_system1.31325851
43MP0006036_abnormal_mitochondrial_physio1.29995016
44MP0002398_abnormal_bone_marrow1.29891517
45MP0001661_extended_life_span1.29236340
46MP0004147_increased_porphyrin_level1.28988899
47MP0003121_genomic_imprinting1.26301524
48MP0003950_abnormal_plasma_membrane1.22190781
49MP0003186_abnormal_redox_activity1.19072117
50MP0002009_preneoplasia1.18972417
51MP0002837_dystrophic_cardiac_calcinosis1.17686379
52MP0003698_abnormal_male_reproductive1.17182469
53MP0001835_abnormal_antigen_presentation1.16900553
54MP0005380_embryogenesis_phenotype1.16841625
55MP0001672_abnormal_embryogenesis/_devel1.16841625
56MP0001697_abnormal_embryo_size1.16401212
57MP0003315_abnormal_perineum_morphology1.15782102
58MP0008789_abnormal_olfactory_epithelium1.14560238
59MP0002080_prenatal_lethality1.10663842
60MP0003984_embryonic_growth_retardation1.09909054
61MP0000689_abnormal_spleen_morphology1.09468966
62MP0000703_abnormal_thymus_morphology1.09286484
63MP0005379_endocrine/exocrine_gland_phen1.07087183
64MP0002088_abnormal_embryonic_growth/wei1.03468615
65MP0005389_reproductive_system_phenotype1.00881923
66MP0002722_abnormal_immune_system1.00609592
67MP0002429_abnormal_blood_cell0.98893996
68MP0002938_white_spotting0.98173641
69MP0005174_abnormal_tail_pigmentation0.97768553
70MP0005671_abnormal_response_to0.96741285
71MP0002095_abnormal_skin_pigmentation0.95789498
72MP0002132_abnormal_respiratory_system0.94349278
73MP0003646_muscle_fatigue0.92890054
74MP0002085_abnormal_embryonic_tissue0.92649774
75MP0000015_abnormal_ear_pigmentation0.91108492
76MP0000858_altered_metastatic_potential0.90479885
77MP0003567_abnormal_fetal_cardiomyocyte0.89056792
78MP0002148_abnormal_hypersensitivity_rea0.88781686
79MP0000716_abnormal_immune_system0.88429062
80MP0001853_heart_inflammation0.88395582
81MP0010352_gastrointestinal_tract_polyps0.87628813
82MP0001529_abnormal_vocalization0.84524054
83MP0003943_abnormal_hepatobiliary_system0.83375790
84MP0005075_abnormal_melanosome_morpholog0.82849201
85MP0005646_abnormal_pituitary_gland0.81663994
86MP0002161_abnormal_fertility/fecundity0.81557690
87MP0005253_abnormal_eye_physiology0.80209364
88MP0005410_abnormal_fertilization0.79503788
89MP0002420_abnormal_adaptive_immunity0.79106315
90MP0002086_abnormal_extraembryonic_tissu0.79082335
91MP0005395_other_phenotype0.78474003
92MP0001819_abnormal_immune_cell0.77186252
93MP0009053_abnormal_anal_canal0.77063357
94MP0009379_abnormal_foot_pigmentation0.76965072
95MP0002006_tumorigenesis0.75664861
96MP0001764_abnormal_homeostasis0.75105654
97MP0004197_abnormal_fetal_growth/weight/0.75041425
98MP0005408_hypopigmentation0.74427452
99MP0003890_abnormal_embryonic-extraembry0.73845185
100MP0001188_hyperpigmentation0.73605230
101MP0001873_stomach_inflammation0.72836691
102MP0000647_abnormal_sebaceous_gland0.72291969
103MP0008875_abnormal_xenobiotic_pharmacok0.71233838
104MP0002102_abnormal_ear_morphology0.71056417
105MP0000566_synostosis0.69617417
106MP0002166_altered_tumor_susceptibility0.68983772
107MP0005636_abnormal_mineral_homeostasis0.68899378
108MP0001984_abnormal_olfaction0.68016058
109MP0008873_increased_physiological_sensi0.67505320
110MP0001919_abnormal_reproductive_system0.66291098
111MP0001800_abnormal_humoral_immune0.65695428
112MP0003699_abnormal_female_reproductive0.65393315
113MP0009785_altered_susceptibility_to0.65328707
114MP0002163_abnormal_gland_morphology0.65200173
115MP0002452_abnormal_antigen_presenting0.64401343
116MP0001293_anophthalmia0.63884300
117MP0004215_abnormal_myocardial_fiber0.63716601
118MP0005377_hearing/vestibular/ear_phenot0.63482155
119MP0003878_abnormal_ear_physiology0.63482155
120MP0002139_abnormal_hepatobiliary_system0.62278864
121MP0005332_abnormal_amino_acid0.60127231
122MP0002084_abnormal_developmental_patter0.60049127
123MP0005266_abnormal_metabolism0.59664882
124MP0001243_abnormal_dermal_layer0.59307326
125MP0003787_abnormal_imprinting0.59266684
126MP0003656_abnormal_erythrocyte_physiolo0.58998776
127MP0002277_abnormal_respiratory_mucosa0.58720687
128MP0008872_abnormal_physiological_respon0.58717730
129MP0002723_abnormal_immune_serum0.58389541
130MP0005000_abnormal_immune_tolerance0.57841430
131MP0003941_abnormal_skin_development0.57123718
132MP0003936_abnormal_reproductive_system0.55038031
133MP0001881_abnormal_mammary_gland0.54543596
134MP0002282_abnormal_trachea_morphology0.54455430
135MP0005645_abnormal_hypothalamus_physiol0.51115545

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)4.81922111
2Acute necrotizing encephalopathy (HP:0006965)4.62195230
3Abnormal number of erythroid precursors (HP:0012131)4.59548558
4Aplastic anemia (HP:0001915)4.58785901
5Abnormality of cells of the erythroid lineage (HP:0012130)4.36363329
6Abnormal mitochondria in muscle tissue (HP:0008316)4.22042609
7Acute encephalopathy (HP:0006846)4.19946096
8Mitochondrial inheritance (HP:0001427)4.14554656
9Chromsome breakage (HP:0040012)4.12083330
10Reticulocytopenia (HP:0001896)4.01489814
11Progressive macrocephaly (HP:0004481)3.99567704
12Chromosomal breakage induced by crosslinking agents (HP:0003221)3.82024440
13Hepatocellular necrosis (HP:0001404)3.80845365
1411 pairs of ribs (HP:0000878)3.61948966
15Hepatic necrosis (HP:0002605)3.60330228
16Breast hypoplasia (HP:0003187)3.46773056
17Abnormal spermatogenesis (HP:0008669)3.23506773
18Cerebral edema (HP:0002181)3.21660621
19Lipid accumulation in hepatocytes (HP:0006561)3.19676433
20Oral leukoplakia (HP:0002745)3.08875307
21Abnormality of chromosome stability (HP:0003220)3.05727297
22Renal Fanconi syndrome (HP:0001994)3.03690821
23Type I transferrin isoform profile (HP:0003642)2.94077299
24Patellar aplasia (HP:0006443)2.93373586
25Meckel diverticulum (HP:0002245)2.91031954
26Abnormality of the heme biosynthetic pathway (HP:0010472)2.86095736
27Abnormality of the preputium (HP:0100587)2.84924378
28Lactic acidosis (HP:0003128)2.83507646
29Methylmalonic acidemia (HP:0002912)2.78283649
30Abnormality of the ileum (HP:0001549)2.78197675
31Carpal bone hypoplasia (HP:0001498)2.73913260
32Myelodysplasia (HP:0002863)2.73822558
33Abnormality of the anterior horn cell (HP:0006802)2.72796694
34Degeneration of anterior horn cells (HP:0002398)2.72796694
35Increased intramyocellular lipid droplets (HP:0012240)2.70799875
36Aplasia/Hypoplasia of the patella (HP:0006498)2.68388244
37Azoospermia (HP:0000027)2.67639021
38Abnormal lung lobation (HP:0002101)2.66780519
39Absent thumb (HP:0009777)2.66489486
40Aplasia/Hypoplasia of the uvula (HP:0010293)2.64125648
41Impulsivity (HP:0100710)2.63915682
42Colon cancer (HP:0003003)2.61872761
43Bone marrow hypocellularity (HP:0005528)2.55078498
44Abnormality of the renal collecting system (HP:0004742)2.54712826
45Microretrognathia (HP:0000308)2.51319424
46Small intestinal stenosis (HP:0012848)2.50214429
47Duodenal stenosis (HP:0100867)2.50214429
48Pallor (HP:0000980)2.49189597
49Gonadotropin excess (HP:0000837)2.46498390
50Respiratory failure (HP:0002878)2.44856545
51Macrocytic anemia (HP:0001972)2.44626371
52Pancytopenia (HP:0001876)2.44384853
53Exercise intolerance (HP:0003546)2.43448047
54Methylmalonic aciduria (HP:0012120)2.39583546
55Premature graying of hair (HP:0002216)2.38615587
56Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.34100997
57Abnormality of alanine metabolism (HP:0010916)2.34100997
58Hyperalaninemia (HP:0003348)2.34100997
59Rough bone trabeculation (HP:0100670)2.33896922
60Volvulus (HP:0002580)2.31948465
61Duplicated collecting system (HP:0000081)2.29031001
62Abnormality of methionine metabolism (HP:0010901)2.28874466
63Sloping forehead (HP:0000340)2.26322970
64Lethargy (HP:0001254)2.25931672
65Cleft eyelid (HP:0000625)2.23597606
66Thrombocytosis (HP:0001894)2.23252360
67Pulmonary fibrosis (HP:0002206)2.18812366
68Medulloblastoma (HP:0002885)2.17838827
69Increased serum pyruvate (HP:0003542)2.15524006
70Generalized aminoaciduria (HP:0002909)2.14488436
71Type 2 muscle fiber atrophy (HP:0003554)2.13846598
72Ectopic kidney (HP:0000086)2.13664473
73Abnormality of the pons (HP:0007361)2.12868916
74Microvesicular hepatic steatosis (HP:0001414)2.10575100
75Secondary amenorrhea (HP:0000869)2.09917115
76Nephroblastoma (Wilms tumor) (HP:0002667)2.08390083
77Supernumerary spleens (HP:0009799)2.06461495
78Hyperglycinemia (HP:0002154)2.06208139
79Cerebral hypomyelination (HP:0006808)2.06097380
80Increased muscle lipid content (HP:0009058)2.05742580
81Selective tooth agenesis (HP:0001592)2.05143628
82Increased serum lactate (HP:0002151)2.04568995
83Neoplasm of the pancreas (HP:0002894)2.02648745
84Optic disc pallor (HP:0000543)2.02479934
85Reduced antithrombin III activity (HP:0001976)2.02223365
86Agnosia (HP:0010524)2.01099585
87Abnormality of the duodenum (HP:0002246)2.01025836
88Clubbing of toes (HP:0100760)1.99984783
89Poor head control (HP:0002421)1.99964804
90Lymphoma (HP:0002665)1.98888885
913-Methylglutaconic aciduria (HP:0003535)1.97703934
92CNS demyelination (HP:0007305)1.97406605
93Muscle fiber atrophy (HP:0100295)1.96660650
94Horseshoe kidney (HP:0000085)1.95510654
95Abnormality of the calcaneus (HP:0008364)1.95399835
96Exertional dyspnea (HP:0002875)1.94694053
97Short middle phalanx of the 5th finger (HP:0004220)1.93898542
98Atrophy/Degeneration involving motor neurons (HP:0007373)1.93537323
99Abnormality of the fingertips (HP:0001211)1.93520092
100Leukodystrophy (HP:0002415)1.93393684
101Abnormality of glycolysis (HP:0004366)1.92152376
102Embryonal renal neoplasm (HP:0011794)1.91137736
103Triphalangeal thumb (HP:0001199)1.90620190
104Increased hepatocellular lipid droplets (HP:0006565)1.90430666
105Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.90080276
106Decreased activity of mitochondrial respiratory chain (HP:0008972)1.90080276
107Congenital, generalized hypertrichosis (HP:0004540)1.89768827
108Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.88986669
109Abnormal protein N-linked glycosylation (HP:0012347)1.88986669
110Abnormal protein glycosylation (HP:0012346)1.88986669
111Abnormal glycosylation (HP:0012345)1.88986669
112Abnormality of renal resorption (HP:0011038)1.88778077
113Abnormality of aspartate family amino acid metabolism (HP:0010899)1.88764738
114Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.88251543
115Absent radius (HP:0003974)1.87927221
116Hypoplasia of the pons (HP:0012110)1.87674022
117Calcaneovalgus deformity (HP:0001848)1.86902617
118Increased CSF lactate (HP:0002490)1.86760550
119B lymphocytopenia (HP:0010976)1.86084046
120Optic nerve coloboma (HP:0000588)1.85345004
121Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.83500999
122Cellular immunodeficiency (HP:0005374)1.82188886
123Abnormality of the labia minora (HP:0012880)1.81900930
124Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.81812350
125Acute myeloid leukemia (HP:0004808)1.81466223
126Abnormality of serum amino acid levels (HP:0003112)1.80908260
127True hermaphroditism (HP:0010459)1.80572799
128Abnormality of urine glucose concentration (HP:0011016)1.80448676
129Glycosuria (HP:0003076)1.80448676
130Tubulointerstitial nephritis (HP:0001970)1.79663849
131Abnormality of lateral ventricle (HP:0030047)1.78778487
132Hypoplasia of the capital femoral epiphysis (HP:0003090)1.78260841
133Short thumb (HP:0009778)1.77672758
134Pancreatic fibrosis (HP:0100732)1.77602951
135Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.75153973
136Medial flaring of the eyebrow (HP:0010747)1.75069325
137Hypoglycemic coma (HP:0001325)1.74570414
138Progressive microcephaly (HP:0000253)1.74469937
139Abnormality of dicarboxylic acid metabolism (HP:0010995)1.74239154
140Dicarboxylic aciduria (HP:0003215)1.74239154
141Abnormal trabecular bone morphology (HP:0100671)1.73872046
142Irregular epiphyses (HP:0010582)1.73842696
143Neoplasm of the colon (HP:0100273)1.73250168
144Oligodactyly (hands) (HP:0001180)1.73041740
145Abnormality of B cell number (HP:0010975)1.72983764
146Aplasia/Hypoplasia of the sacrum (HP:0008517)1.72472022
147Abnormality of placental membranes (HP:0011409)1.72099003
148Amniotic constriction ring (HP:0009775)1.72099003
149Abnormality of DNA repair (HP:0003254)1.71417710
150Male pseudohermaphroditism (HP:0000037)1.71401454
151Aplasia involving forearm bones (HP:0009822)1.71393895
152Absent forearm bone (HP:0003953)1.71393895
153Rhabdomyosarcoma (HP:0002859)1.71002864
154Respiratory difficulties (HP:0002880)1.69918016

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NEK18.18189311
2NEK24.10634022
3CDC73.78313746
4VRK23.77398058
5BUB13.42459402
6WEE13.39371656
7ACVR1B3.07531835
8PLK42.98758436
9EIF2AK12.62069036
10EIF2AK32.42733726
11STK162.26725131
12BRSK22.24900782
13PDK22.11643573
14SRPK12.11457546
15VRK12.07110282
16CCNB11.81686893
17MKNK11.73870264
18PLK11.60019104
19TTK1.59943138
20ZAK1.55037532
21MAP3K121.54454630
22PNCK1.49512371
23AURKB1.49082870
24NME21.46223745
25BRSK11.42469698
26TRIM281.40829112
27MKNK21.40087419
28ATR1.38689335
29BMPR1B1.38328102
30BCKDK1.36760853
31DYRK31.32517476
32PLK31.31315193
33RPS6KA41.30582758
34PIM21.28860359
35TAF11.23101020
36PASK1.22364056
37TSSK61.22157974
38CDK71.22052606
39CLK11.21140700
40IRAK41.20567054
41CHEK21.19541563
42CDK81.19384479
43MAP4K21.04528057
44FRK1.01444194
45TEC1.00666633
46WNK30.97068217
47MST40.96573425
48CSNK1G10.90243355
49AURKA0.89577835
50CHEK10.86863831
51STK40.86289562
52TLK10.85608922
53EIF2AK20.84788936
54PIM10.83206050
55DAPK10.82906046
56INSRR0.81091103
57BRAF0.75082806
58CDK190.71733022
59CDK40.71274750
60PBK0.71066707
61ADRBK20.70676556
62MUSK0.70579691
63ATM0.69215359
64RPS6KB20.68568391
65TXK0.68083660
66GRK10.66047403
67MAP4K10.63823072
68OXSR10.63441825
69CSNK1G30.62982500
70MAP3K80.61741245
71CSNK2A10.61591595
72TESK10.60440648
73STK100.57893633
74CDK30.57806680
75PINK10.56360999
76BMPR20.56252967
77MELK0.54374624
78STK240.54067088
79TGFBR10.52785836
80IKBKB0.52512796
81ERBB30.50840282
82TAOK30.49029453
83ABL20.48519234
84CDK20.48198107
85KIT0.47968710
86BCR0.47706449
87LIMK10.46859148
88STK38L0.46591328
89BTK0.45925786
90RPS6KA50.45388044
91STK390.45064314
92IRAK30.44968292
93CSNK2A20.44520205
94JAK30.43948687
95CDK10.43751709
96MAPKAPK50.43572662
97MAP3K30.43458198
98CSNK1G20.40486450
99NUAK10.38398825
100RPS6KC10.36932289
101RPS6KL10.36932289
102STK30.36789747
103RPS6KA60.36068484
104PDK30.34759362
105PDK40.34759362
106TESK20.33525706
107NEK90.33352690
108SCYL20.33126999
109MARK30.32967239
110MST1R0.32703794
111MYLK0.32448195
112RPS6KB10.31017936
113ARAF0.28659975
114YES10.28446994
115PRKCI0.27781560
116PRKCQ0.27616982
117NME10.27280278
118CSNK1A1L0.27167990
119KDR0.25466725
120CHUK0.25111364
121PLK20.24304040
122PAK10.24047817
123MET0.23539987
124ZAP700.22852007
125CDK120.21958180
126CDK60.20751033
127SIK30.20385984
128MAP3K60.18333104
129LYN0.17766600
130NLK0.16313862
131MAP2K30.16294460
132AKT10.16260314
133FLT30.15993258
134RAF10.15432192
135DYRK20.15350303
136PAK40.15226705

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030305.31558573
2Mismatch repair_Homo sapiens_hsa034304.40781746
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.68682740
4Proteasome_Homo sapiens_hsa030503.43750334
5Homologous recombination_Homo sapiens_hsa034403.42120660
6Base excision repair_Homo sapiens_hsa034103.18274142
7Ribosome_Homo sapiens_hsa030103.11075402
8RNA polymerase_Homo sapiens_hsa030203.10058778
9Spliceosome_Homo sapiens_hsa030403.02484631
10Nucleotide excision repair_Homo sapiens_hsa034202.99341446
11RNA transport_Homo sapiens_hsa030132.78875223
12Cell cycle_Homo sapiens_hsa041102.66138934
13Pyrimidine metabolism_Homo sapiens_hsa002402.63165238
14Basal transcription factors_Homo sapiens_hsa030222.42524842
15One carbon pool by folate_Homo sapiens_hsa006702.39533646
16Fanconi anemia pathway_Homo sapiens_hsa034602.36507553
17Non-homologous end-joining_Homo sapiens_hsa034502.34243007
18RNA degradation_Homo sapiens_hsa030182.15349071
19Protein export_Homo sapiens_hsa030601.99983808
20Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.83039589
21mRNA surveillance pathway_Homo sapiens_hsa030151.69305203
22p53 signaling pathway_Homo sapiens_hsa041151.56801474
23Purine metabolism_Homo sapiens_hsa002301.51018730
24Propanoate metabolism_Homo sapiens_hsa006401.50523516
25Fatty acid elongation_Homo sapiens_hsa000621.42148086
26Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.41665165
27Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.33645916
28Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.32224573
29Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.26715878
30Epstein-Barr virus infection_Homo sapiens_hsa051691.07738397
31Huntingtons disease_Homo sapiens_hsa050161.03045205
32Herpes simplex infection_Homo sapiens_hsa051681.01041789
33Parkinsons disease_Homo sapiens_hsa050120.99142788
34Pyruvate metabolism_Homo sapiens_hsa006200.95126758
35Sulfur metabolism_Homo sapiens_hsa009200.94631631
36Antigen processing and presentation_Homo sapiens_hsa046120.93151860
37Systemic lupus erythematosus_Homo sapiens_hsa053220.92538122
38Peroxisome_Homo sapiens_hsa041460.91821532
39Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.91592521
402-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.89428742
41Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.86222971
42Oocyte meiosis_Homo sapiens_hsa041140.80409105
43Steroid biosynthesis_Homo sapiens_hsa001000.79914839
44Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.77132654
45Selenocompound metabolism_Homo sapiens_hsa004500.76425939
46Pentose phosphate pathway_Homo sapiens_hsa000300.74646155
47Legionellosis_Homo sapiens_hsa051340.70585661
48Folate biosynthesis_Homo sapiens_hsa007900.70099319
49Oxidative phosphorylation_Homo sapiens_hsa001900.67293863
50N-Glycan biosynthesis_Homo sapiens_hsa005100.66691497
51Viral carcinogenesis_Homo sapiens_hsa052030.65531267
52Drug metabolism - other enzymes_Homo sapiens_hsa009830.65484151
53Primary immunodeficiency_Homo sapiens_hsa053400.65368659
54Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.65121118
55Butanoate metabolism_Homo sapiens_hsa006500.64843918
56Collecting duct acid secretion_Homo sapiens_hsa049660.63796931
57Thyroid cancer_Homo sapiens_hsa052160.63742038
58Allograft rejection_Homo sapiens_hsa053300.62970966
59Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.62618595
60HTLV-I infection_Homo sapiens_hsa051660.62440399
61Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.57555428
62Caffeine metabolism_Homo sapiens_hsa002320.56543906
63Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.55981292
64Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.54358307
65Vitamin B6 metabolism_Homo sapiens_hsa007500.54115602
66Rheumatoid arthritis_Homo sapiens_hsa053230.52862422
67Measles_Homo sapiens_hsa051620.52446463
68Cysteine and methionine metabolism_Homo sapiens_hsa002700.52207810
69Intestinal immune network for IgA production_Homo sapiens_hsa046720.51725585
70Cardiac muscle contraction_Homo sapiens_hsa042600.51444742
71Graft-versus-host disease_Homo sapiens_hsa053320.50971788
72Glutathione metabolism_Homo sapiens_hsa004800.50826428
73Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.48833666
74Nitrogen metabolism_Homo sapiens_hsa009100.46015394
75Primary bile acid biosynthesis_Homo sapiens_hsa001200.44743748
76Sulfur relay system_Homo sapiens_hsa041220.44102440
77Tryptophan metabolism_Homo sapiens_hsa003800.43989712
78Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.43867908
79Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.42920435
80Transcriptional misregulation in cancer_Homo sapiens_hsa052020.42892155
81Regulation of autophagy_Homo sapiens_hsa041400.42183047
82Small cell lung cancer_Homo sapiens_hsa052220.41240902
83Fatty acid metabolism_Homo sapiens_hsa012120.40927545
84Type I diabetes mellitus_Homo sapiens_hsa049400.39250587
85Autoimmune thyroid disease_Homo sapiens_hsa053200.38835030
86Influenza A_Homo sapiens_hsa051640.38468149
87NF-kappa B signaling pathway_Homo sapiens_hsa040640.38067774
88Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.37945603
89Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.37677530
90Phototransduction_Homo sapiens_hsa047440.37579103
91Hepatitis B_Homo sapiens_hsa051610.37198640
92RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.36830849
93Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.35149967
94Hematopoietic cell lineage_Homo sapiens_hsa046400.33786981
95Apoptosis_Homo sapiens_hsa042100.33666784
96Arachidonic acid metabolism_Homo sapiens_hsa005900.33526890
97Maturity onset diabetes of the young_Homo sapiens_hsa049500.33365505
98Pentose and glucuronate interconversions_Homo sapiens_hsa000400.33295305
99Chemical carcinogenesis_Homo sapiens_hsa052040.32976971
100Alzheimers disease_Homo sapiens_hsa050100.32853699
101MicroRNAs in cancer_Homo sapiens_hsa052060.32722743
102Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.32611442
103Metabolic pathways_Homo sapiens_hsa011000.30904482
104Cyanoamino acid metabolism_Homo sapiens_hsa004600.29644112
105Fatty acid degradation_Homo sapiens_hsa000710.29005476
106Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.27229779
107Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.27228723
108SNARE interactions in vesicular transport_Homo sapiens_hsa041300.26617273
109Alcoholism_Homo sapiens_hsa050340.26560159
110Asthma_Homo sapiens_hsa053100.26325693
111Biosynthesis of amino acids_Homo sapiens_hsa012300.26102758
112Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.25768122
113Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.24694985
114Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.22429172
115NOD-like receptor signaling pathway_Homo sapiens_hsa046210.19982861
116Steroid hormone biosynthesis_Homo sapiens_hsa001400.18233700
117TGF-beta signaling pathway_Homo sapiens_hsa043500.17493587
118beta-Alanine metabolism_Homo sapiens_hsa004100.17469628
119Shigellosis_Homo sapiens_hsa051310.16823849
120Leishmaniasis_Homo sapiens_hsa051400.16219662
121Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.12318893
122Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.12066058
123Linoleic acid metabolism_Homo sapiens_hsa005910.11975713
124Viral myocarditis_Homo sapiens_hsa054160.11431520
125Carbon metabolism_Homo sapiens_hsa012000.09784174
126Colorectal cancer_Homo sapiens_hsa052100.09315055
127Galactose metabolism_Homo sapiens_hsa000520.07950404
128Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.06504227
129Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.06364525
130Renin-angiotensin system_Homo sapiens_hsa046140.06097818
131Pathways in cancer_Homo sapiens_hsa052000.04996148
132Prostate cancer_Homo sapiens_hsa052150.04784932
133Jak-STAT signaling pathway_Homo sapiens_hsa046300.04774086
134Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.04634224
135Pertussis_Homo sapiens_hsa051330.03819435

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