TEX28

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1female mating behavior (GO:0060180)8.97281258
2negative regulation of T cell receptor signaling pathway (GO:0050860)7.89745666
3monocyte chemotaxis (GO:0002548)7.16411498
4negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)6.72605505
5adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)5.49126080
6relaxation of smooth muscle (GO:0044557)5.41652772
7transmission of nerve impulse (GO:0019226)5.10977683
8protein-chromophore linkage (GO:0018298)5.08317632
9regulation of T cell receptor signaling pathway (GO:0050856)5.00106044
10multicellular organismal reproductive behavior (GO:0033057)4.55218308
11intestinal epithelial cell development (GO:0060576)4.22937594
12indolalkylamine metabolic process (GO:0006586)4.21104546
13L-methionine biosynthetic process from methylthioadenosine (GO:0019509)4.19685816
14limb bud formation (GO:0060174)4.13377197
15cytidine metabolic process (GO:0046087)4.03912395
16cytidine catabolic process (GO:0006216)4.03912395
17cytidine deamination (GO:0009972)4.03912395
18regulation of chemokine-mediated signaling pathway (GO:0070099)4.03792693
19positive regulation of T cell chemotaxis (GO:0010820)3.94807446
20regulation of T cell chemotaxis (GO:0010819)3.94807446
21regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.93970630
22adaptation of signaling pathway (GO:0023058)3.91149795
23pyrimidine ribonucleoside catabolic process (GO:0046133)3.86696489
24regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.86462449
25phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)3.84757385
26negative regulation of smooth muscle contraction (GO:0045986)3.80260314
27regulation of chronic inflammatory response (GO:0002676)3.72654399
28phasic smooth muscle contraction (GO:0014821)3.69122505
29DNA deamination (GO:0045006)3.68317850
30amine catabolic process (GO:0009310)3.65674997
31cellular biogenic amine catabolic process (GO:0042402)3.65674997
32positive regulation of interleukin-2 production (GO:0032743)3.64715068
33meiotic chromosome segregation (GO:0045132)3.64126320
34amino acid salvage (GO:0043102)3.44812436
35L-methionine salvage (GO:0071267)3.44812436
36L-methionine biosynthetic process (GO:0071265)3.44812436
37S-adenosylmethionine metabolic process (GO:0046500)3.40476261
38keratinocyte development (GO:0003334)3.40161177
39nephron tubule formation (GO:0072079)3.32891571
40tryptophan metabolic process (GO:0006568)3.29338038
41neural tube formation (GO:0001841)3.28743769
42otic vesicle formation (GO:0030916)3.28085248
43dopamine transport (GO:0015872)3.27980752
44negative regulation of cytosolic calcium ion concentration (GO:0051481)3.27539612
45opioid receptor signaling pathway (GO:0038003)3.23541407
46cellular response to ATP (GO:0071318)3.23533106
47regulation of activation of Janus kinase activity (GO:0010533)3.23110424
48histone H3-K4 trimethylation (GO:0080182)3.20449387
49inner ear receptor stereocilium organization (GO:0060122)3.16640319
50peristalsis (GO:0030432)3.13976679
51indole-containing compound metabolic process (GO:0042430)3.07349001
52proline biosynthetic process (GO:0006561)3.03906677
53negative regulation of myotube differentiation (GO:0010832)3.03483624
54long term synaptic depression (GO:0060292)3.00746392
55negative regulation of muscle contraction (GO:0045932)2.94392940
56single strand break repair (GO:0000012)2.93940972
57regulation of neurotransmitter uptake (GO:0051580)2.92933039
58cellular response to interleukin-15 (GO:0071350)2.91849662
59synaptic transmission, dopaminergic (GO:0001963)2.87160583
60NLS-bearing protein import into nucleus (GO:0006607)2.86390175
61multi-organism reproductive behavior (GO:0044705)2.86224907
62nucleotide transmembrane transport (GO:1901679)2.84973308
63tryptophan catabolic process (GO:0006569)2.84810292
64indole-containing compound catabolic process (GO:0042436)2.84810292
65indolalkylamine catabolic process (GO:0046218)2.84810292
66reproductive behavior (GO:0019098)2.82914627
67positive regulation of T cell apoptotic process (GO:0070234)2.82455127
68regulation of cell migration involved in sprouting angiogenesis (GO:0090049)2.81353453
69regulation of microtubule-based movement (GO:0060632)2.81209905
70nucleoside diphosphate catabolic process (GO:0009134)2.76619966
71startle response (GO:0001964)2.76548216
72positive regulation of monocyte chemotaxis (GO:0090026)2.74681920
73negative regulation of B cell proliferation (GO:0030889)2.73887624
74tyrosine phosphorylation of STAT protein (GO:0007260)2.71273718
75eosinophil chemotaxis (GO:0048245)2.70447841
76positive regulation of uterine smooth muscle contraction (GO:0070474)2.70352721
77embryonic epithelial tube formation (GO:0001838)2.69967256
78regulation of interleukin-2 production (GO:0032663)2.66760711
79regulation of regulatory T cell differentiation (GO:0045589)2.66720041
80positive regulation of NF-kappaB import into nucleus (GO:0042346)2.65208546
81glial cell proliferation (GO:0014009)2.56945674
82tachykinin receptor signaling pathway (GO:0007217)2.56126668
83catecholamine transport (GO:0051937)2.56093835
84myoblast migration (GO:0051451)2.54332253
85peptidyl-lysine trimethylation (GO:0018023)2.54328836
86vocalization behavior (GO:0071625)2.54076214
87response to catecholamine (GO:0071869)2.54068830
88response to monoamine (GO:0071867)2.54068830
89epithelial tube formation (GO:0072175)2.50180358
90positive regulation of extracellular matrix organization (GO:1903055)2.49216812
91pyrimidine-containing compound transmembrane transport (GO:0072531)2.49087274
92positive regulation of interleukin-8 secretion (GO:2000484)2.49083964
93positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)2.47800912
94detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.47663222
95spinal cord development (GO:0021510)2.47215658
96regulation of T cell migration (GO:2000404)2.47066499
97regulation of rhodopsin mediated signaling pathway (GO:0022400)2.46554797
98DNA demethylation (GO:0080111)2.45778141
99regulation of acrosome reaction (GO:0060046)2.45242185
100regulation of female receptivity (GO:0045924)10.4331418

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.82902452
2EZH2_22144423_ChIP-Seq_EOC_Human3.19892070
3VDR_22108803_ChIP-Seq_LS180_Human3.17968200
4GBX2_23144817_ChIP-Seq_PC3_Human3.02761423
5BP1_19119308_ChIP-ChIP_Hs578T_Human2.53768253
6ZNF274_21170338_ChIP-Seq_K562_Hela2.52275505
7STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.36837666
8POU3F2_20337985_ChIP-ChIP_501MEL_Human2.36360068
9IGF1R_20145208_ChIP-Seq_DFB_Human2.36233268
10TAF15_26573619_Chip-Seq_HEK293_Human2.35730401
11STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.32973372
12TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.25436291
13POU5F1_26923725_Chip-Seq_MESODERM_Mouse2.25436291
14TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.24077716
15FUS_26573619_Chip-Seq_HEK293_Human2.14769706
16P300_19829295_ChIP-Seq_ESCs_Human2.08202339
17E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.95777161
18CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.92717162
19IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.90129116
20TP53_16413492_ChIP-PET_HCT116_Human1.88277675
21* TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.86272390
22CTBP2_25329375_ChIP-Seq_LNCAP_Human1.79586776
23PIAS1_25552417_ChIP-Seq_VCAP_Human1.74998367
24ER_23166858_ChIP-Seq_MCF-7_Human1.74419542
25FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.73810504
26PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.69660730
27CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.69063291
28FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.61731038
29BCAT_22108803_ChIP-Seq_LS180_Human1.60949985
30SOX2_19829295_ChIP-Seq_ESCs_Human1.58770063
31NANOG_19829295_ChIP-Seq_ESCs_Human1.58770063
32AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.58197109
33CTBP1_25329375_ChIP-Seq_LNCAP_Human1.52313912
34RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.51103923
35UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.50630853
36RXR_22108803_ChIP-Seq_LS180_Human1.48633676
37TCF4_23295773_ChIP-Seq_U87_Human1.45571341
38EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.44634783
39PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.44034036
40TCF4_22108803_ChIP-Seq_LS180_Human1.42624808
41STAT3_23295773_ChIP-Seq_U87_Human1.38626481
42KLF5_20875108_ChIP-Seq_MESCs_Mouse1.37098636
43ZFP57_27257070_Chip-Seq_ESCs_Mouse1.36557238
44GATA3_21878914_ChIP-Seq_MCF-7_Human1.35504189
45CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.30146134
46EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.29779744
47FOXA1_21572438_ChIP-Seq_LNCaP_Human1.29660749
48MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.29063949
49PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.28017237
50ESR1_20079471_ChIP-ChIP_T-47D_Human1.24466791
51TDRD3_21172665_ChIP-Seq_MCF-7_Human1.22679093
52EGR1_23403033_ChIP-Seq_LIVER_Mouse1.22212855
53CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.21969301
54ETV2_25802403_ChIP-Seq_MESCs_Mouse1.21881739
55ZNF217_24962896_ChIP-Seq_MCF-7_Human1.21881092
56SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.20571947
57PRDM14_20953172_ChIP-Seq_ESCs_Human1.19235706
58MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.19117368
59CBP_20019798_ChIP-Seq_JUKART_Human1.19033953
60IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.19033953
61TOP2B_26459242_ChIP-Seq_MCF-7_Human1.18047301
62SUZ12_27294783_Chip-Seq_NPCs_Mouse1.17973121
63HOXB7_26014856_ChIP-Seq_BT474_Human1.17826099
64ELF1_17652178_ChIP-ChIP_JURKAT_Human1.14633682
65SMAD3_21741376_ChIP-Seq_EPCs_Human1.14339875
66AR_25329375_ChIP-Seq_VCAP_Human1.13100090
67SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.12662417
68FOXM1_26456572_ChIP-Seq_MCF-7_Human1.12443081
69SMAD4_21799915_ChIP-Seq_A2780_Human1.12422303
70MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.12083267
71TP53_22573176_ChIP-Seq_HFKS_Human1.11973763
72HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.11107863
73EWS_26573619_Chip-Seq_HEK293_Human1.08384440
74PKCTHETA_26484144_Chip-Seq_BREAST_Human1.06564606
75TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.05038588
76FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.03023584
77FLI1_21867929_ChIP-Seq_TH2_Mouse1.01977349
78SMRT_27268052_Chip-Seq_Bcells_Human1.01044389
79SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.99332929
80BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.98486869
81RUNX_20019798_ChIP-Seq_JUKART_Human0.98233111
82CJUN_26792858_Chip-Seq_BT549_Human0.98206411
83EZH2_27294783_Chip-Seq_NPCs_Mouse0.97263618
84FOXA1_25329375_ChIP-Seq_VCAP_Human0.94919276
85FOXA1_27270436_Chip-Seq_PROSTATE_Human0.94919276
86IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.94630885
87GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.94520263
88AHR_22903824_ChIP-Seq_MCF-7_Human0.93882876
89POU5F1_16153702_ChIP-ChIP_HESCs_Human0.92909334
90RUNX2_22187159_ChIP-Seq_PCA_Human0.92326702
91NCOR_22424771_ChIP-Seq_293T_Human0.91983948
92AUTS2_25519132_ChIP-Seq_293T-REX_Human0.91596140
93GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.91493947
94ARNT_22903824_ChIP-Seq_MCF-7_Human0.90950130
95NANOG_18555785_Chip-Seq_ESCs_Mouse0.90450556
96GATA3_26560356_Chip-Seq_TH2_Human0.90295640
97SMAD4_21741376_ChIP-Seq_EPCs_Human0.90200126
98KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.89768520
99OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.89387368
100EGR1_19032775_ChIP-ChIP_M12_Human0.89076910

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003136_yellow_coat_color8.42196488
2MP0009780_abnormal_chondrocyte_physiolo4.84723994
3MP0002132_abnormal_respiratory_system3.91459423
4MP0002163_abnormal_gland_morphology3.47049968
5MP0000372_irregular_coat_pigmentation3.22252370
6MP0004381_abnormal_hair_follicle3.03577116
7MP0005646_abnormal_pituitary_gland2.55161527
8MP0005379_endocrine/exocrine_gland_phen2.26408359
9MP0001968_abnormal_touch/_nociception2.19483213
10MP0005187_abnormal_penis_morphology2.17335724
11MP0003045_fibrosis2.16494468
12MP0004885_abnormal_endolymph2.13797248
13MP0006276_abnormal_autonomic_nervous2.10974364
14MP0003938_abnormal_ear_development2.08623200
15MP0005671_abnormal_response_to2.08233056
16MP0002638_abnormal_pupillary_reflex1.87701954
17MP0005360_urolithiasis1.85764571
18MP0000647_abnormal_sebaceous_gland1.79550761
19MP0000537_abnormal_urethra_morphology1.73933907
20MP0003879_abnormal_hair_cell1.70503918
21MP0002909_abnormal_adrenal_gland1.67699353
22MP0002736_abnormal_nociception_after1.56001695
23MP0002138_abnormal_hepatobiliary_system1.55005057
24MP0005410_abnormal_fertilization1.52719977
25MP0005670_abnormal_white_adipose1.46270045
26MP0002282_abnormal_trachea_morphology1.42436786
27MP0002090_abnormal_vision1.42097210
28MP0004145_abnormal_muscle_electrophysio1.39664111
29MP0008872_abnormal_physiological_respon1.36462021
30MP0001485_abnormal_pinna_reflex1.29834630
31MP0003567_abnormal_fetal_cardiomyocyte1.29139714
32MP0005551_abnormal_eye_electrophysiolog1.26605532
33MP0001984_abnormal_olfaction1.24239226
34MP0002168_other_aberrant_phenotype1.23886657
35MP0004782_abnormal_surfactant_physiolog1.21008606
36MP0000230_abnormal_systemic_arterial1.19466671
37MP0009333_abnormal_splenocyte_physiolog1.18375397
38MP0002653_abnormal_ependyma_morphology1.17967155
39MP0001501_abnormal_sleep_pattern1.17102432
40MP0008775_abnormal_heart_ventricle1.15262032
41MP0009765_abnormal_xenobiotic_induced1.11589259
42MP0001486_abnormal_startle_reflex1.06488689
43MP0000538_abnormal_urinary_bladder1.05134863
44MP0005310_abnormal_salivary_gland1.03765887
45MP0005395_other_phenotype1.03027218
46MP0008004_abnormal_stomach_pH1.00867405
47MP0003718_maternal_effect0.98543220
48MP0004742_abnormal_vestibular_system0.98497650
49MP0001764_abnormal_homeostasis0.97043741
50MP0003122_maternal_imprinting0.95444132
51MP0000516_abnormal_urinary_system0.94583122
52MP0005367_renal/urinary_system_phenotyp0.94583122
53MP0000049_abnormal_middle_ear0.89669102
54MP0006035_abnormal_mitochondrial_morpho0.88500202
55MP0002938_white_spotting0.88371259
56MP0003646_muscle_fatigue0.86337714
57MP0008961_abnormal_basal_metabolism0.84456004
58MP0009745_abnormal_behavioral_response0.83814124
59MP0005075_abnormal_melanosome_morpholog0.81180660
60MP0002277_abnormal_respiratory_mucosa0.80936381
61MP0001529_abnormal_vocalization0.79688617
62MP0002735_abnormal_chemical_nociception0.78671981
63MP0009764_decreased_sensitivity_to0.77011184
64MP0002148_abnormal_hypersensitivity_rea0.76316843
65MP0000613_abnormal_salivary_gland0.75672807
66MP0001853_heart_inflammation0.74728623
67MP0002405_respiratory_system_inflammati0.74044827
68MP0005645_abnormal_hypothalamus_physiol0.72981291
69MP0010155_abnormal_intestine_physiology0.72619473
70MP0003828_pulmonary_edema0.72617681
71MP0003724_increased_susceptibility_to0.72419077
72MP0003638_abnormal_response/metabolism_0.72374229
73MP0000631_abnormal_neuroendocrine_gland0.70754129
74MP0001963_abnormal_hearing_physiology0.69356959
75MP0008875_abnormal_xenobiotic_pharmacok0.68471788
76MP0000026_abnormal_inner_ear0.67560011
77MP0004085_abnormal_heartbeat0.67253241
78MP0002233_abnormal_nose_morphology0.66446361
79MP0002751_abnormal_autonomic_nervous0.66068138
80MP0003755_abnormal_palate_morphology0.65725252
81MP0000778_abnormal_nervous_system0.64229790
82MP0009785_altered_susceptibility_to0.62553667
83MP0001905_abnormal_dopamine_level0.61331671
84MP0001346_abnormal_lacrimal_gland0.60634462
85MP0000534_abnormal_ureter_morphology0.60523649
86MP0003880_abnormal_central_pattern0.59942451
87MP0003937_abnormal_limbs/digits/tail_de0.59431869
88MP0004130_abnormal_muscle_cell0.59275439
89MP0003942_abnormal_urinary_system0.58337798
90MP0001502_abnormal_circadian_rhythm0.58039127
91MP0002557_abnormal_social/conspecific_i0.57980368
92MP0008995_early_reproductive_senescence0.56422773
93MP0001800_abnormal_humoral_immune0.56409637
94MP0001851_eye_inflammation0.55756228
95MP0009278_abnormal_bone_marrow0.53109966
96MP0002876_abnormal_thyroid_physiology0.52765746
97MP0000685_abnormal_immune_system0.52452821
98MP0005253_abnormal_eye_physiology0.51105647
99MP0008789_abnormal_olfactory_epithelium0.49849419
100MP0000569_abnormal_digit_pigmentation0.49790414

Predicted human phenotypes

RankGene SetZ-score
1Concave nail (HP:0001598)5.25343223
2Thyroid-stimulating hormone excess (HP:0002925)4.93879137
3Severe visual impairment (HP:0001141)3.87730340
4Abnormality of lateral ventricle (HP:0030047)3.78826909
5Neonatal respiratory distress (HP:0002643)3.49644764
6Keratoconjunctivitis sicca (HP:0001097)3.44234978
7True hermaphroditism (HP:0010459)3.41808570
8Abnormal rod and cone electroretinograms (HP:0008323)3.39177166
9Keratoconjunctivitis (HP:0001096)3.38417639
10Type I diabetes mellitus (HP:0100651)3.36886906
11Hypoproteinemia (HP:0003075)3.36087116
1211 pairs of ribs (HP:0000878)3.22138051
13Hemiparesis (HP:0001269)3.17539383
14Premature skin wrinkling (HP:0100678)3.06113225
15Attenuation of retinal blood vessels (HP:0007843)3.00679344
16Congenital stationary night blindness (HP:0007642)2.93274069
17Tubular atrophy (HP:0000092)2.92402009
18Abnormality of midbrain morphology (HP:0002418)2.77420806
19Molar tooth sign on MRI (HP:0002419)2.77420806
20Stomatitis (HP:0010280)2.76531423
21Keratitis (HP:0000491)2.68758283
22Anhidrosis (HP:0000970)2.67069219
23Abolished electroretinogram (ERG) (HP:0000550)2.66285976
24Mesangial abnormality (HP:0001966)2.65955199
25Intestinal atresia (HP:0011100)2.62393321
26Pancreatic cysts (HP:0001737)2.60890451
27Conical tooth (HP:0000698)2.59896005
28Hypoplastic iliac wings (HP:0002866)2.59112880
29Gaze-evoked nystagmus (HP:0000640)2.57980912
30Short chin (HP:0000331)2.57175310
31Febrile seizures (HP:0002373)2.57010925
32Hyperventilation (HP:0002883)2.55721314
33Absent eyebrow (HP:0002223)2.54813481
34Hypoalbuminemia (HP:0003073)2.53159848
35Abnormal albumin level (HP:0012116)2.53159848
36Oligodontia (HP:0000677)2.52861390
37Retinal dysplasia (HP:0007973)2.52375445
38Broad alveolar ridges (HP:0000187)2.51022714
39Focal seizures (HP:0007359)2.48233426
40Abnormality of the dental root (HP:0006486)2.48076782
41Taurodontia (HP:0000679)2.48076782
42Abnormality of permanent molar morphology (HP:0011071)2.48076782
43Cerebellar dysplasia (HP:0007033)2.45328454
44Hypothermia (HP:0002045)2.45327745
45Bony spicule pigmentary retinopathy (HP:0007737)2.42946836
46Pigmentary retinal degeneration (HP:0001146)2.42530600
47T lymphocytopenia (HP:0005403)2.36177735
48Sparse eyelashes (HP:0000653)2.35781491
49Abnormality of molar morphology (HP:0011070)2.34546540
50Abnormality of molar (HP:0011077)2.34546540
51Abnormality of the dental pulp (HP:0006479)2.34250601
52Agitation (HP:0000713)2.33554940
53Abnormality of the anterior horn cell (HP:0006802)2.26296369
54Degeneration of anterior horn cells (HP:0002398)2.26296369
55Hypoplastic nipples (HP:0002557)2.25353428
56Thyroiditis (HP:0100646)2.21063456
57Elevated erythrocyte sedimentation rate (HP:0003565)2.20147958
58Respiratory difficulties (HP:0002880)2.20071821
59Abnormality of macular pigmentation (HP:0008002)2.19802571
60X-linked dominant inheritance (HP:0001423)2.19459671
61Albinism (HP:0001022)2.16311909
62Narrow forehead (HP:0000341)2.16262816
63Bifid tongue (HP:0010297)2.14782705
64Brittle hair (HP:0002299)2.14492904
65Abnormality of T cell number (HP:0011839)2.13887095
66Depressed nasal tip (HP:0000437)2.12547525
67Abnormality of the labia minora (HP:0012880)2.11653758
68Large for gestational age (HP:0001520)2.09519475
69Medial flaring of the eyebrow (HP:0010747)2.08373472
70Choroideremia (HP:0001139)2.07924445
71Increased connective tissue (HP:0009025)2.05798311
723-Methylglutaconic aciduria (HP:0003535)2.02545577
73Diastasis recti (HP:0001540)2.00816708
74Optic nerve hypoplasia (HP:0000609)2.00547894
75Severe combined immunodeficiency (HP:0004430)2.00443605
76Erythroderma (HP:0001019)1.99360301
77IgG deficiency (HP:0004315)1.98907581
78Gangrene (HP:0100758)1.98162479
79Prominent supraorbital ridges (HP:0000336)1.98073638
80Cystic liver disease (HP:0006706)1.91901735
81Fibular hypoplasia (HP:0003038)1.89213631
82Decreased electroretinogram (ERG) amplitude (HP:0000654)1.89101835
83Microvesicular hepatic steatosis (HP:0001414)1.86871435
84Facial hemangioma (HP:0000329)1.86014711
85Pancreatic fibrosis (HP:0100732)1.85953905
86Optic neuritis (HP:0100653)1.85451652
87Retrobulbar optic neuritis (HP:0100654)1.85451652
88Renal hypoplasia (HP:0000089)1.80017375
89Type II lissencephaly (HP:0007260)1.79944473
90Keratoconus (HP:0000563)1.78095963
91Increased corneal curvature (HP:0100692)1.78095963
92Ureteral obstruction (HP:0006000)1.77547125
93Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.74882573
94Abnormality of transition element cation homeostasis (HP:0011030)1.74201646
95Aplasia/Hypoplasia of the fovea (HP:0008060)1.71227345
96Hypoplasia of the fovea (HP:0007750)1.71227345
97Cupped ear (HP:0000378)1.68493358
98Amelogenesis imperfecta (HP:0000705)1.67517997
99Sex reversal (HP:0012245)1.67391250
100Abnormal sex determination (HP:0012244)1.67391250

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK5.47885432
2CASK4.10550024
3FRK4.02399159
4ADRBK23.45541021
5MST43.31603589
6MAP4K23.21921645
7EPHB22.61253117
8TAF12.44754745
9WNK32.34682494
10NUAK12.33216153
11TLK12.16926466
12EPHA42.08634296
13STK161.84489033
14ERBB21.77155060
15TYRO31.73018768
16IRAK31.70292586
17BUB11.70156282
18PINK11.62602198
19ACVR1B1.55344602
20PIK3CG1.54396980
21MAPKAPK31.53869844
22OXSR11.44796952
23IRAK11.37696454
24FES1.36921853
25PAK31.33556803
26IKBKB1.31409671
27INSRR1.27522400
28BCKDK1.23409191
29DMPK1.21797234
30TNK21.20349745
31PRKCG1.05556527
32CHUK1.04313184
33KSR11.03957339
34KIT1.03053591
35ICK1.02424219
36PRKCE1.02096009
37PRKCI1.01493649
38BMPR20.98308037
39GRK10.97934196
40ILK0.92958069
41PLK20.92453173
42IKBKE0.92359523
43NTRK20.92327084
44PRKD30.90489005
45PNCK0.89825109
46MARK10.89531925
47CDK120.88789852
48MAP3K120.83810520
49STK390.83772473
50PRKCQ0.83257149
51ADRBK10.82365188
52TBK10.78726539
53SYK0.77017080
54ZAP700.75933325
55CAMK1G0.74384301
56DYRK1A0.68902762
57ITK0.61873689
58ROCK10.61346727
59EPHA20.59761259
60DAPK10.58762491
61VRK10.56869366
62DAPK20.56176109
63KDR0.55841788
64MAP3K100.55333021
65DYRK30.53559502
66DYRK20.52838425
67CDK190.50416190
68CSK0.50047542
69CAMK10.49831483
70TAOK30.48570019
71TNIK0.47111506
72TEC0.46079878
73CAMK2A0.44765207
74LYN0.41936173
75MYLK0.40991771
76FGR0.39882023
77JAK20.38546322
78LCK0.37749022
79MINK10.37542306
80CSNK2A10.35596175
81MAP2K10.33829640
82MAP3K140.33742812
83CDK50.32811926
84MAPK70.32571470
85CSNK1G20.31678802
86PRKCH0.31074050
87STK38L0.30893581
88TRIM280.30450012
89IRAK40.30217602
90PRKCD0.29550066
91ABL10.28687753
92CAMK40.28554803
93MAP3K40.28427065
94LATS20.27330233
95VRK20.27155716
96STK30.26172742
97PRKACA0.25555875
98JAK30.25532447
99PRKACG0.23475928
100MKNK20.22950344

Predicted pathways (KEGG)

RankGene SetZ-score
1Tryptophan metabolism_Homo sapiens_hsa003803.60439057
2Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006013.06650001
3Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.81673168
4Caffeine metabolism_Homo sapiens_hsa002322.49356131
5Selenocompound metabolism_Homo sapiens_hsa004502.39445368
6Primary immunodeficiency_Homo sapiens_hsa053402.36010580
7Olfactory transduction_Homo sapiens_hsa047402.20228703
8Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.18265365
9Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.16445382
10Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.15778659
11Nitrogen metabolism_Homo sapiens_hsa009101.94684597
12Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.93713551
13Circadian entrainment_Homo sapiens_hsa047131.76021815
14Autoimmune thyroid disease_Homo sapiens_hsa053201.75992808
15Nicotine addiction_Homo sapiens_hsa050331.68184465
16Phototransduction_Homo sapiens_hsa047441.68056216
17Rheumatoid arthritis_Homo sapiens_hsa053231.59836384
18NOD-like receptor signaling pathway_Homo sapiens_hsa046211.59119845
19Basal transcription factors_Homo sapiens_hsa030221.58234298
20Graft-versus-host disease_Homo sapiens_hsa053321.57650691
21Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.56860059
22Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.56014888
23Salivary secretion_Homo sapiens_hsa049701.49746929
24Morphine addiction_Homo sapiens_hsa050321.49416418
25T cell receptor signaling pathway_Homo sapiens_hsa046601.48821133
26Steroid hormone biosynthesis_Homo sapiens_hsa001401.43014007
27alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.40311139
28Chemokine signaling pathway_Homo sapiens_hsa040621.37435338
29Linoleic acid metabolism_Homo sapiens_hsa005911.36363798
30Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.33650127
31Measles_Homo sapiens_hsa051621.25366927
32Arginine and proline metabolism_Homo sapiens_hsa003301.25346629
33Retinol metabolism_Homo sapiens_hsa008301.18534013
34Allograft rejection_Homo sapiens_hsa053301.17221416
35Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.11316570
36Taste transduction_Homo sapiens_hsa047421.11285018
37Intestinal immune network for IgA production_Homo sapiens_hsa046721.10594388
38ABC transporters_Homo sapiens_hsa020101.10526886
39Circadian rhythm_Homo sapiens_hsa047101.10040232
40Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.09788622
41Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.04129063
42Butanoate metabolism_Homo sapiens_hsa006501.02770442
43cAMP signaling pathway_Homo sapiens_hsa040241.01010613
44Hematopoietic cell lineage_Homo sapiens_hsa046400.98424994
45Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.97052707
46Sulfur metabolism_Homo sapiens_hsa009200.95409562
47Jak-STAT signaling pathway_Homo sapiens_hsa046300.91348826
48Staphylococcus aureus infection_Homo sapiens_hsa051500.85782784
49N-Glycan biosynthesis_Homo sapiens_hsa005100.83863832
50GABAergic synapse_Homo sapiens_hsa047270.83147458
51Chemical carcinogenesis_Homo sapiens_hsa052040.83084418
52Calcium signaling pathway_Homo sapiens_hsa040200.82879609
53Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.81298622
54Purine metabolism_Homo sapiens_hsa002300.80821001
55Glycosaminoglycan degradation_Homo sapiens_hsa005310.80260669
56Antigen processing and presentation_Homo sapiens_hsa046120.79013699
57Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.78026516
58Serotonergic synapse_Homo sapiens_hsa047260.77011861
59Toll-like receptor signaling pathway_Homo sapiens_hsa046200.75621550
60Collecting duct acid secretion_Homo sapiens_hsa049660.74635256
61RNA polymerase_Homo sapiens_hsa030200.74461628
62Sulfur relay system_Homo sapiens_hsa041220.68950390
63Dopaminergic synapse_Homo sapiens_hsa047280.68908201
64Type I diabetes mellitus_Homo sapiens_hsa049400.67596150
65Oxidative phosphorylation_Homo sapiens_hsa001900.66404963
66Lysine degradation_Homo sapiens_hsa003100.63053822
67Prion diseases_Homo sapiens_hsa050200.62788713
68NF-kappa B signaling pathway_Homo sapiens_hsa040640.62306409
69Platelet activation_Homo sapiens_hsa046110.58151138
70Legionellosis_Homo sapiens_hsa051340.55946643
71Fatty acid degradation_Homo sapiens_hsa000710.54222912
72Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.54035591
73Homologous recombination_Homo sapiens_hsa034400.52709142
74Renin secretion_Homo sapiens_hsa049240.51578326
75Thyroid hormone signaling pathway_Homo sapiens_hsa049190.51246390
76Regulation of autophagy_Homo sapiens_hsa041400.49198649
77Dorso-ventral axis formation_Homo sapiens_hsa043200.47337022
78TNF signaling pathway_Homo sapiens_hsa046680.46808045
79Proteasome_Homo sapiens_hsa030500.46234139
80Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.43938842
81Sphingolipid metabolism_Homo sapiens_hsa006000.42878501
82Glutamatergic synapse_Homo sapiens_hsa047240.42602947
83Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.42506704
84RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.41908327
85Mineral absorption_Homo sapiens_hsa049780.41645082
86Ovarian steroidogenesis_Homo sapiens_hsa049130.40101005
87Primary bile acid biosynthesis_Homo sapiens_hsa001200.38792456
88Glycerolipid metabolism_Homo sapiens_hsa005610.37934151
89Arachidonic acid metabolism_Homo sapiens_hsa005900.37539658
90Long-term depression_Homo sapiens_hsa047300.37114573
91Tyrosine metabolism_Homo sapiens_hsa003500.36110371
92Alcoholism_Homo sapiens_hsa050340.34551176
93Pentose and glucuronate interconversions_Homo sapiens_hsa000400.34547093
94Fatty acid biosynthesis_Homo sapiens_hsa000610.33983247
95Cocaine addiction_Homo sapiens_hsa050300.33457290
96Folate biosynthesis_Homo sapiens_hsa007900.32495821
97Epstein-Barr virus infection_Homo sapiens_hsa051690.32244683
98Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.31540421
99Vascular smooth muscle contraction_Homo sapiens_hsa042700.31195698
100Parkinsons disease_Homo sapiens_hsa050120.30853109

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