TEX26

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cilium movement (GO:0003341)9.99254826
2epithelial cilium movement (GO:0003351)9.33785464
3piRNA metabolic process (GO:0034587)8.58924441
4epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)7.47088689
5motile cilium assembly (GO:0044458)7.40174503
6multicellular organism reproduction (GO:0032504)7.39970504
7male meiosis (GO:0007140)7.26338338
8cilium or flagellum-dependent cell motility (GO:0001539)7.24512914
9sperm motility (GO:0030317)6.48859177
10fusion of sperm to egg plasma membrane (GO:0007342)6.46655117
11sperm-egg recognition (GO:0035036)6.23190315
12cell wall macromolecule metabolic process (GO:0044036)6.14885221
13cell wall macromolecule catabolic process (GO:0016998)6.14885221
14binding of sperm to zona pellucida (GO:0007339)6.08658018
15reproduction (GO:0000003)6.02095161
16meiotic cell cycle (GO:0051321)5.92188704
17spermatid development (GO:0007286)5.58995685
18axoneme assembly (GO:0035082)5.47750858
19DNA methylation involved in gamete generation (GO:0043046)5.43487576
20cell-cell recognition (GO:0009988)5.43359920
21single fertilization (GO:0007338)5.41375598
22microtubule bundle formation (GO:0001578)5.39638429
23acrosome assembly (GO:0001675)5.32961107
24synaptonemal complex organization (GO:0070193)5.21469350
25microtubule severing (GO:0051013)5.19295573
26male meiosis I (GO:0007141)5.17119360
27synaptonemal complex assembly (GO:0007130)5.09617444
28fertilization (GO:0009566)5.06874974
29ventricular system development (GO:0021591)5.05181084
30regulation of cilium movement (GO:0003352)5.01828809
31plasma membrane fusion (GO:0045026)4.86982613
32microtubule polymerization or depolymerization (GO:0031109)4.80521626
33acrosome reaction (GO:0007340)4.77380089
34regulation of female gonad development (GO:2000194)4.74428442
35regulation of microtubule-based movement (GO:0060632)4.69061908
36meiosis I (GO:0007127)4.56386728
37gamete generation (GO:0007276)4.48974658
38spermatogenesis (GO:0007283)4.45468294
39male gamete generation (GO:0048232)4.44140729
40left/right axis specification (GO:0070986)4.41595733
41intraciliary transport (GO:0042073)4.40930877
42female gamete generation (GO:0007292)4.40023276
43regulation of meiosis (GO:0040020)4.39034438
44meiotic nuclear division (GO:0007126)4.36372918
45cell projection assembly (GO:0030031)4.28800184
46cilium organization (GO:0044782)4.22612948
47microtubule depolymerization (GO:0007019)4.12190063
48protein localization to cilium (GO:0061512)4.02465144
49cilium assembly (GO:0042384)4.02032852
50protein polyglutamylation (GO:0018095)4.01358758
51smoothened signaling pathway (GO:0007224)3.92457180
52glomerular epithelial cell development (GO:0072310)3.90758553
53mitotic metaphase plate congression (GO:0007080)3.90494966
54cilium morphogenesis (GO:0060271)3.83437463
55primary alcohol catabolic process (GO:0034310)3.81958924
56regulation of meiosis I (GO:0060631)3.80320852
57nucleoside diphosphate phosphorylation (GO:0006165)3.75647182
58negative regulation of inclusion body assembly (GO:0090084)3.75204579
59histone H2A monoubiquitination (GO:0035518)3.73049159
60regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.71582428
61negative regulation of meiosis (GO:0045835)3.70150515
62ethanol metabolic process (GO:0006067)3.69841592
63lung epithelium development (GO:0060428)3.67725633
64oocyte maturation (GO:0001556)3.64958350
65centriole replication (GO:0007099)3.59951625
66regulation of meiotic cell cycle (GO:0051445)3.57918270
67negative regulation of retinoic acid receptor signaling pathway (GO:0048387)3.57311491
68determination of left/right symmetry (GO:0007368)3.57251713
69centriole assembly (GO:0098534)3.56386917
70female gonad development (GO:0008585)3.56123844
71germ cell development (GO:0007281)3.53546962
72chromosome organization involved in meiosis (GO:0070192)3.52573987
73regulation of sister chromatid cohesion (GO:0007063)3.51967781
74vitamin transmembrane transport (GO:0035461)3.51330511
75multicellular organismal reproductive process (GO:0048609)3.50774568
76sperm capacitation (GO:0048240)3.49959740
77monoubiquitinated protein deubiquitination (GO:0035520)3.49510873
78one-carbon compound transport (GO:0019755)3.48285292
79gene silencing by RNA (GO:0031047)3.44802271
80cellular process involved in reproduction in multicellular organism (GO:0022412)3.44566241
81histone exchange (GO:0043486)3.43270952
82meiotic cell cycle process (GO:1903046)3.41051354
83metaphase plate congression (GO:0051310)3.40482439
84determination of bilateral symmetry (GO:0009855)3.40363096
85establishment of chromosome localization (GO:0051303)3.38143205
86cellular component assembly involved in morphogenesis (GO:0010927)3.37056789
87regulation of exit from mitosis (GO:0007096)3.36360958
88specification of symmetry (GO:0009799)3.34215659
89attachment of spindle microtubules to kinetochore (GO:0008608)3.32268175
90GTP biosynthetic process (GO:0006183)3.30256818
91mitotic chromosome condensation (GO:0007076)3.22886547
92retinal rod cell development (GO:0046548)3.19611450
93microtubule-based movement (GO:0007018)3.19508790
94positive regulation of smoothened signaling pathway (GO:0045880)3.19453363
95diterpenoid biosynthetic process (GO:0016102)3.18820794
96lateral ventricle development (GO:0021670)3.18522692
97chromosome condensation (GO:0030261)3.16665859
98mitotic sister chromatid segregation (GO:0000070)3.15116361
99spermatid nucleus differentiation (GO:0007289)3.14618320
100histone H2A ubiquitination (GO:0033522)3.13486720
101regulation of acrosome reaction (GO:0060046)3.09214217
102nonmotile primary cilium assembly (GO:0035058)3.09026034
103regulation of interleukin-5 production (GO:0032674)3.08662914
104type B pancreatic cell development (GO:0003323)3.07741573
105DNA damage induced protein phosphorylation (GO:0006975)3.07536986
106DNA methylation (GO:0006306)3.06995280
107DNA alkylation (GO:0006305)3.06995280
108protein K6-linked ubiquitination (GO:0085020)3.04053943
109pyrimidine-containing compound transmembrane transport (GO:0072531)3.02479050
110maturation of 5.8S rRNA (GO:0000460)3.01278919
111single strand break repair (GO:0000012)2.99845361
112meiotic chromosome segregation (GO:0045132)2.99009083
113regulation of centriole replication (GO:0046599)2.97029076
114microtubule-based process (GO:0007017)2.95881599
115ethanol oxidation (GO:0006069)2.93785358
116regulation of interleukin-13 production (GO:0032656)2.92547124
117phosphatidylethanolamine biosynthetic process (GO:0006646)2.92440768
118organelle assembly (GO:0070925)2.92051594
119negative regulation of meiotic cell cycle (GO:0051447)2.92042319
120establishment of apical/basal cell polarity (GO:0035089)2.87878200
121chromatin remodeling at centromere (GO:0031055)2.87793268
122negative regulation of T cell differentiation in thymus (GO:0033085)2.86954284
123cytoplasmic microtubule organization (GO:0031122)2.85920165
124establishment of tissue polarity (GO:0007164)2.85570863
125establishment of planar polarity (GO:0001736)2.85570863
126regulation of inclusion body assembly (GO:0090083)2.85494814
127regulation of transforming growth factor beta2 production (GO:0032909)2.85218150
128left/right pattern formation (GO:0060972)2.84386067
129positive regulation of meiosis (GO:0045836)2.83432557
130UTP biosynthetic process (GO:0006228)2.82410513
131mitotic sister chromatid cohesion (GO:0007064)2.82018195
132regulation of smoothened signaling pathway (GO:0008589)2.78107719
133phosphatidylethanolamine metabolic process (GO:0046337)2.77297008
134terpenoid biosynthetic process (GO:0016114)2.68942152
135establishment or maintenance of monopolar cell polarity (GO:0061339)2.66013257
136establishment of monopolar cell polarity (GO:0061162)2.66013257
137negative regulation of JUN kinase activity (GO:0043508)2.63943494
138intra-S DNA damage checkpoint (GO:0031573)2.62292033
139spinal cord motor neuron differentiation (GO:0021522)2.60308678
140photoreceptor cell maintenance (GO:0045494)2.60163880
141glutathione derivative metabolic process (GO:1901685)2.59769760
142glutathione derivative biosynthetic process (GO:1901687)2.59769760
143negative regulation of B cell mediated immunity (GO:0002713)2.54567767
144negative regulation of immunoglobulin mediated immune response (GO:0002890)2.54567767
145response to xenobiotic stimulus (GO:0009410)2.53803328
146protein refolding (GO:0042026)2.51580489
147tongue development (GO:0043586)2.50225261
148retinoic acid metabolic process (GO:0042573)2.41832512
149response to pheromone (GO:0019236)2.40863923
150telencephalon development (GO:0021537)2.40594445
151lateral sprouting from an epithelium (GO:0060601)2.40332017
152heart looping (GO:0001947)2.35479764
153regulation of autophagic vacuole assembly (GO:2000785)2.34771879
154embryonic heart tube morphogenesis (GO:0003143)2.32766086
155phosphatidylcholine biosynthetic process (GO:0006656)2.32745726
156exogenous drug catabolic process (GO:0042738)2.27404624
157neuron fate determination (GO:0048664)2.26940703
158tolerance induction (GO:0002507)2.26908513
159mitochondrion degradation (GO:0000422)2.25865462
160dorsal/ventral neural tube patterning (GO:0021904)2.24240363
161axonemal dynein complex assembly (GO:0070286)10.4762232

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse5.13134327
2TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.46663677
3TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.30277691
4KAP1_22055183_ChIP-Seq_ESCs_Mouse3.02385881
5GATA1_26923725_Chip-Seq_HPCs_Mouse2.79616707
6EZH2_22144423_ChIP-Seq_EOC_Human2.65184421
7DROSHA_22980978_ChIP-Seq_HELA_Human2.50372372
8GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.48284655
9FOXM1_23109430_ChIP-Seq_U2OS_Human2.39620557
10GBX2_23144817_ChIP-Seq_PC3_Human2.35918411
11FLI1_27457419_Chip-Seq_LIVER_Mouse2.35475953
12MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.35068383
13RNF2_27304074_Chip-Seq_NSC_Mouse2.29792138
14VDR_22108803_ChIP-Seq_LS180_Human2.25895194
15PIAS1_25552417_ChIP-Seq_VCAP_Human2.23683575
16CTBP1_25329375_ChIP-Seq_LNCAP_Human2.16426204
17STAT6_21828071_ChIP-Seq_BEAS2B_Human2.10649838
18CTBP2_25329375_ChIP-Seq_LNCAP_Human2.03379098
19PCGF2_27294783_Chip-Seq_ESCs_Mouse1.98766920
20PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.96426580
21HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.94614100
22BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.93416921
23POU3F2_20337985_ChIP-ChIP_501MEL_Human1.93093975
24NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.92162119
25NR3C1_21868756_ChIP-Seq_MCF10A_Human1.89088420
26MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.87426002
27MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.82809806
28FUS_26573619_Chip-Seq_HEK293_Human1.81066363
29KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.75743754
30FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.74950718
31FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.73268725
32AR_21572438_ChIP-Seq_LNCaP_Human1.71356910
33TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.68692351
34TP53_18474530_ChIP-ChIP_U2OS_Human1.68173626
35RBPJ_22232070_ChIP-Seq_NCS_Mouse1.66521287
36ARNT_22903824_ChIP-Seq_MCF-7_Human1.63503849
37CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.60717803
38NANOG_18555785_Chip-Seq_ESCs_Mouse1.60665787
39SMAD3_21741376_ChIP-Seq_EPCs_Human1.58234972
40RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.57797861
41ELK4_26923725_Chip-Seq_MESODERM_Mouse1.56760816
42TAL1_26923725_Chip-Seq_HPCs_Mouse1.55300993
43RUNX1_26923725_Chip-Seq_HPCs_Mouse1.55267394
44STAT1_17558387_ChIP-Seq_HELA_Human1.54655986
45EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.53828195
46TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.53384579
47SALL1_21062744_ChIP-ChIP_HESCs_Human1.52180135
48ER_23166858_ChIP-Seq_MCF-7_Human1.50965557
49AHR_22903824_ChIP-Seq_MCF-7_Human1.48473735
50ZNF274_21170338_ChIP-Seq_K562_Hela1.48370605
51ZFP57_27257070_Chip-Seq_ESCs_Mouse1.47218157
52FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.47041877
53SUZ12_27294783_Chip-Seq_NPCs_Mouse1.46446533
54AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.44854766
55TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.44434158
56PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.44267709
57POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.44233563
58TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.44233563
59KDM2B_26808549_Chip-Seq_REH_Human1.41063147
60ESR1_20079471_ChIP-ChIP_T-47D_Human1.40489217
61CBX2_27304074_Chip-Seq_ESCs_Mouse1.40178279
62AR_21909140_ChIP-Seq_LNCAP_Human1.38824558
63PHF8_20622853_ChIP-Seq_HELA_Human1.38576264
64NFE2_27457419_Chip-Seq_LIVER_Mouse1.38564942
65EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.37814060
66AR_25329375_ChIP-Seq_VCAP_Human1.37491989
67CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.37210005
68CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.37206021
69CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.35664798
70HNFA_21074721_ChIP-Seq_CACO-2_Human1.35011244
71SMAD4_21799915_ChIP-Seq_A2780_Human1.32575757
72STAT3_18555785_Chip-Seq_ESCs_Mouse1.31690327
73ERG_20517297_ChIP-Seq_VCAP_Human1.31566478
74TCF4_22108803_ChIP-Seq_LS180_Human1.31309046
75RUNX2_22187159_ChIP-Seq_PCA_Human1.29341577
76STAT3_23295773_ChIP-Seq_U87_Human1.28587790
77CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.28237265
78GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.27577868
79SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.27443166
80NFYB_21822215_ChIP-Seq_K562_Human1.27319057
81GF1B_26923725_Chip-Seq_HPCs_Mouse1.27113747
82ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.26663263
83ZNF217_24962896_ChIP-Seq_MCF-7_Human1.26455132
84FLI1_21867929_ChIP-Seq_TH2_Mouse1.26293401
85P53_22387025_ChIP-Seq_ESCs_Mouse1.25776529
86BCAT_22108803_ChIP-Seq_LS180_Human1.24967201
87MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.24117257
88TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.23945933
89EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.23671663
90KLF4_18555785_Chip-Seq_ESCs_Mouse1.22563484
91GATA3_21867929_ChIP-Seq_TH1_Mouse1.21336334
92SOX2_18555785_Chip-Seq_ESCs_Mouse1.21252170
93CBX2_22325352_ChIP-Seq_293T-Rex_Human1.21245044
94TCF4_23295773_ChIP-Seq_U87_Human1.19963237
95CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.19849230
96CMYC_18555785_Chip-Seq_ESCs_Mouse1.19566777
97LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.19456113
98FOXM1_26456572_ChIP-Seq_MCF-7_Human1.18858560
99PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.18238990
100EZH2_27294783_Chip-Seq_NPCs_Mouse1.18177196
101TP63_23658742_ChIP-Seq_EP156T_Human1.17963729
102OCT4_18555785_Chip-Seq_ESCs_Mouse1.17757801
103P53_22127205_ChIP-Seq_FIBROBLAST_Human1.17432143
104SUZ12_18555785_Chip-Seq_ESCs_Mouse1.16863163
105EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.16743020
106RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.14918764
107LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.14062975
108EZH2_27294783_Chip-Seq_ESCs_Mouse1.13737353
109UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.13056753
110ESRRB_18555785_Chip-Seq_ESCs_Mouse1.12674312
111ZFX_18555785_Chip-Seq_ESCs_Mouse1.12458784
112P300_19829295_ChIP-Seq_ESCs_Human1.12446087
113SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.11776721
114BMI1_23680149_ChIP-Seq_NPCS_Mouse1.11615571
115TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.10785262
116RBPJ_21746931_ChIP-Seq_IB4_Human1.10747557
117CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.10467447
118P300_18555785_Chip-Seq_ESCs_Mouse1.10287291
119SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.10275194
120SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.09104407
121GF1_26923725_Chip-Seq_HPCs_Mouse1.09021932
122CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.08377489
123TBL1_22424771_ChIP-Seq_293T_Human1.08187592
124CTCF_18555785_Chip-Seq_ESCs_Mouse1.08111577
125CRX_20693478_ChIP-Seq_RETINA_Mouse1.07662412
126GATA6_21074721_ChIP-Seq_CACO-2_Human1.07145417
127TDRD3_21172665_ChIP-Seq_MCF-7_Human1.06828976
128GATA3_21867929_ChIP-Seq_CD8_Mouse1.06663039
129TAF15_26573619_Chip-Seq_HEK293_Human1.05927685
130SMAD3_21741376_ChIP-Seq_ESCs_Human1.05798923
131E2F1_18555785_Chip-Seq_ESCs_Mouse1.05530142
132CDX2_22108803_ChIP-Seq_LS180_Human1.05248856
133SMAD4_21741376_ChIP-Seq_EPCs_Human1.05095008
134SOX2_22085726_ChIP-Seq_NPCs_Mouse1.04567904
135RXR_22108803_ChIP-Seq_LS180_Human1.04495294
136ETV1_20927104_ChIP-Seq_GIST48_Human1.04018222
137NMYC_18555785_Chip-Seq_ESCs_Mouse1.03734003
138EP300_21415370_ChIP-Seq_HL-1_Mouse1.03647214
139GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.03236855
140CBP_21632823_ChIP-Seq_H3396_Human1.02873766
141SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.02379747
142RUNX1_27457419_Chip-Seq_LIVER_Mouse1.02253995
143SOX2_21211035_ChIP-Seq_LN229_Gbm1.01924109
144IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.01780982
145CBP_20019798_ChIP-Seq_JUKART_Human1.01780982
146NFYA_21822215_ChIP-Seq_K562_Human1.01719274
147WDR5_24793694_ChIP-Seq_LNCAP_Human1.01204568
148TOP2B_26459242_ChIP-Seq_MCF-7_Human1.01128503
149SMRT_27268052_Chip-Seq_Bcells_Human1.00096202
150EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.00019022
151SMAD4_21741376_ChIP-Seq_HESCs_Human0.99227248
152EWS_26573619_Chip-Seq_HEK293_Human0.99194375
153KLF5_20875108_ChIP-Seq_MESCs_Mouse0.98086286
154AR_19668381_ChIP-Seq_PC3_Human0.97592390
155FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.97498900
156FOXA1_25329375_ChIP-Seq_VCAP_Human0.97006710
157FOXA1_27270436_Chip-Seq_PROSTATE_Human0.97006710
158MYC_19829295_ChIP-Seq_ESCs_Human0.96636438
159SUZ12_27294783_Chip-Seq_ESCs_Mouse0.94600781
160FOXA1_21572438_ChIP-Seq_LNCaP_Human0.94404464
161SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.94206002
162TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.94191475

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization6.26717526
2MP0002653_abnormal_ependyma_morphology4.88641016
3MP0003646_muscle_fatigue4.85293193
4MP0000566_synostosis4.48619041
5MP0003718_maternal_effect4.33982459
6MP0001929_abnormal_gametogenesis4.17858937
7MP0008877_abnormal_DNA_methylation4.09953585
8MP0005377_hearing/vestibular/ear_phenot3.52107534
9MP0003878_abnormal_ear_physiology3.52107534
10MP0002102_abnormal_ear_morphology3.41699496
11MP0003698_abnormal_male_reproductive3.38121585
12MP0002210_abnormal_sex_determination3.08865940
13MP0008875_abnormal_xenobiotic_pharmacok3.05502273
14MP0002132_abnormal_respiratory_system2.82832438
15MP0005646_abnormal_pituitary_gland2.71513702
16MP0000653_abnormal_sex_gland2.71139887
17MP0005451_abnormal_body_composition2.53842625
18MP0002161_abnormal_fertility/fecundity2.52502292
19MP0003136_yellow_coat_color2.45342924
20MP0001145_abnormal_male_reproductive2.36238684
21MP0003693_abnormal_embryo_hatching2.15275098
22MP0003699_abnormal_female_reproductive2.01178081
23MP0005395_other_phenotype2.00573701
24MP0002277_abnormal_respiratory_mucosa1.93402848
25MP0001119_abnormal_female_reproductive1.91626342
26MP0003283_abnormal_digestive_organ1.91182724
27MP0006292_abnormal_olfactory_placode1.90129997
28MP0010094_abnormal_chromosome_stability1.89893164
29MP0005248_abnormal_Harderian_gland1.86116273
30MP0003937_abnormal_limbs/digits/tail_de1.82612372
31MP0003787_abnormal_imprinting1.81412929
32MP0003077_abnormal_cell_cycle1.75168152
33MP0000026_abnormal_inner_ear1.74566043
34MP0010030_abnormal_orbit_morphology1.66912548
35MP0005423_abnormal_somatic_nervous1.64453970
36MP0001293_anophthalmia1.56846460
37MP0002249_abnormal_larynx_morphology1.54871655
38MP0001346_abnormal_lacrimal_gland1.49393703
39MP0000383_abnormal_hair_follicle1.49196169
40MP0001984_abnormal_olfaction1.47120362
41MP0002160_abnormal_reproductive_system1.43193401
42MP0002282_abnormal_trachea_morphology1.42890211
43MP0009053_abnormal_anal_canal1.41022176
44MP0005408_hypopigmentation1.39692057
45MP0003111_abnormal_nucleus_morphology1.37865050
46MP0004957_abnormal_blastocyst_morpholog1.37304627
47MP0005389_reproductive_system_phenotype1.36799935
48MP0008932_abnormal_embryonic_tissue1.36560447
49MP0004270_analgesia1.36001262
50MP0000579_abnormal_nail_morphology1.34574182
51MP0003315_abnormal_perineum_morphology1.33036905
52MP0003950_abnormal_plasma_membrane1.32844015
53MP0008004_abnormal_stomach_pH1.29120150
54MP0003121_genomic_imprinting1.29004723
55MP0006072_abnormal_retinal_apoptosis1.27382682
56MP0009046_muscle_twitch1.26136680
57MP0004043_abnormal_pH_regulation1.25762982
58MP0009780_abnormal_chondrocyte_physiolo1.24970815
59MP0005171_absent_coat_pigmentation1.24463353
60MP0001963_abnormal_hearing_physiology1.24120554
61MP0001486_abnormal_startle_reflex1.23839172
62MP0000462_abnormal_digestive_system1.21730832
63MP0002234_abnormal_pharynx_morphology1.20882392
64MP0001529_abnormal_vocalization1.18657052
65MP0010386_abnormal_urinary_bladder1.14871008
66MP0003938_abnormal_ear_development1.11526962
67MP0008789_abnormal_olfactory_epithelium1.05902559
68MP0000955_abnormal_spinal_cord1.05864827
69MP0000049_abnormal_middle_ear1.05684769
70MP0004145_abnormal_muscle_electrophysio1.03533476
71MP0008058_abnormal_DNA_repair1.03523919
72MP0005310_abnormal_salivary_gland1.03504372
73MP0002085_abnormal_embryonic_tissue1.02536248
74MP0003123_paternal_imprinting1.02397827
75MP0002837_dystrophic_cardiac_calcinosis0.99584342
76MP0002084_abnormal_developmental_patter0.99558891
77MP0003879_abnormal_hair_cell0.99484011
78MP0001970_abnormal_pain_threshold0.98378144
79MP0001919_abnormal_reproductive_system0.97426594
80MP0002735_abnormal_chemical_nociception0.97355339
81MP0000778_abnormal_nervous_system0.96884743
82MP0004019_abnormal_vitamin_homeostasis0.96627692
83MP0005187_abnormal_penis_morphology0.96494315
84MP0009745_abnormal_behavioral_response0.96107941
85MP0004233_abnormal_muscle_weight0.95175084
86MP0002736_abnormal_nociception_after0.94298733
87MP0010678_abnormal_skin_adnexa0.93180424
88MP0000678_abnormal_parathyroid_gland0.93053738
89MP0002272_abnormal_nervous_system0.92716363
90MP0002572_abnormal_emotion/affect_behav0.92689665
91MP0000631_abnormal_neuroendocrine_gland0.92527651
92MP0005391_vision/eye_phenotype0.91531541
93MP0002638_abnormal_pupillary_reflex0.90911265
94MP0005623_abnormal_meninges_morphology0.90268558
95MP0003890_abnormal_embryonic-extraembry0.89934473
96MP0001944_abnormal_pancreas_morphology0.89670987
97MP0001905_abnormal_dopamine_level0.87645375
98MP0000613_abnormal_salivary_gland0.86406270
99MP0003861_abnormal_nervous_system0.85400201
100MP0003755_abnormal_palate_morphology0.84527744
101MP0004264_abnormal_extraembryonic_tissu0.84102454
102MP0002877_abnormal_melanocyte_morpholog0.81987859
103MP0002557_abnormal_social/conspecific_i0.80570463
104MP0002116_abnormal_craniofacial_bone0.80523967
105MP0005365_abnormal_bile_salt0.80279579
106MP0003880_abnormal_central_pattern0.79414372
107MP0002168_other_aberrant_phenotype0.79275694
108MP0001502_abnormal_circadian_rhythm0.79261947
109MP0001968_abnormal_touch/_nociception0.78686359
110MP0009250_abnormal_appendicular_skeleto0.78127908
111MP0005195_abnormal_posterior_eye0.77826573
112MP0004885_abnormal_endolymph0.77732640
113MP0003633_abnormal_nervous_system0.75618179
114MP0005083_abnormal_biliary_tract0.75450213
115MP0002734_abnormal_mechanical_nocicepti0.75423548
116MP0002693_abnormal_pancreas_physiology0.75408374
117MP0006276_abnormal_autonomic_nervous0.75388391
118MP0002067_abnormal_sensory_capabilities0.74526800
119MP0001765_abnormal_ion_homeostasis0.72651753
120MP0005085_abnormal_gallbladder_physiolo0.70767146
121MP0002092_abnormal_eye_morphology0.70566189
122MP0004742_abnormal_vestibular_system0.70411265
123MP0003942_abnormal_urinary_system0.69490057
124MP0005379_endocrine/exocrine_gland_phen0.69380460
125MP0002752_abnormal_somatic_nervous0.69130199
126MP0001730_embryonic_growth_arrest0.67600549
127MP0002229_neurodegeneration0.67472476
128MP0000350_abnormal_cell_proliferation0.67061228
129MP0002928_abnormal_bile_duct0.65001706
130MP0001849_ear_inflammation0.64874462
131MP0001697_abnormal_embryo_size0.64862716
132MP0005499_abnormal_olfactory_system0.64807140
133MP0005394_taste/olfaction_phenotype0.64807140
134MP0002233_abnormal_nose_morphology0.64540873
135MP0000639_abnormal_adrenal_gland0.64324089
136MP0002882_abnormal_neuron_morphology0.61512259
137MP0003656_abnormal_erythrocyte_physiolo0.61427552
138MP0005636_abnormal_mineral_homeostasis0.60465809
139MP0003631_nervous_system_phenotype0.59411572
140MP0001324_abnormal_eye_pigmentation0.59002058
141MP0004133_heterotaxia0.57954569
142MP0005551_abnormal_eye_electrophysiolog0.57148948
143MP0002109_abnormal_limb_morphology0.57068488
144MP0001485_abnormal_pinna_reflex0.56993998
145MP0000432_abnormal_head_morphology0.56076238
146MP0002177_abnormal_outer_ear0.55878792
147MP0002163_abnormal_gland_morphology0.54606703
148MP0005380_embryogenesis_phenotype0.54574456
149MP0001672_abnormal_embryogenesis/_devel0.54574456
150MP0004782_abnormal_surfactant_physiolog0.54172132
151MP0000427_abnormal_hair_cycle0.52075953
152MP0001286_abnormal_eye_development0.52017502
153MP0002295_abnormal_pulmonary_circulatio0.51714830
154MP0005253_abnormal_eye_physiology0.51507580
155MP0002152_abnormal_brain_morphology0.51096269
156MP0009697_abnormal_copulation0.49899619

Predicted human phenotypes

RankGene SetZ-score
1Abnormal ciliary motility (HP:0012262)8.81337895
2Chronic bronchitis (HP:0004469)8.51009095
3Rhinitis (HP:0012384)8.06139662
4Dynein arm defect of respiratory motile cilia (HP:0012255)8.00801815
5Absent/shortened dynein arms (HP:0200106)8.00801815
6Abnormal respiratory epithelium morphology (HP:0012253)6.42822810
7Abnormal respiratory motile cilium morphology (HP:0005938)6.42822810
8Infertility (HP:0000789)5.29203339
9Male infertility (HP:0003251)5.23655575
10Bronchiectasis (HP:0002110)5.05892945
11Pancreatic fibrosis (HP:0100732)4.41777521
12Nasal polyposis (HP:0100582)4.21241669
13Nephronophthisis (HP:0000090)3.80537281
14Chronic sinusitis (HP:0011109)3.80299486
15True hermaphroditism (HP:0010459)3.79654212
16Molar tooth sign on MRI (HP:0002419)3.74056686
17Abnormality of midbrain morphology (HP:0002418)3.74056686
18Bronchitis (HP:0012387)3.72858827
19Pancreatic cysts (HP:0001737)3.46022722
20Abnormality of the nasal mucosa (HP:0000433)3.26217923
21Cystic liver disease (HP:0006706)3.10663460
22Supernumerary spleens (HP:0009799)3.10035758
23Occipital encephalocele (HP:0002085)3.09592960
24Abnormality of the renal medulla (HP:0100957)3.01670014
25Aplasia/Hypoplasia of the tongue (HP:0010295)2.98364511
26Tubulointerstitial nephritis (HP:0001970)2.87449185
27Medial flaring of the eyebrow (HP:0010747)2.84386496
28Papillary thyroid carcinoma (HP:0002895)2.61360153
29Recurrent otitis media (HP:0000403)2.60563227
30Abnormal biliary tract physiology (HP:0012439)2.53132559
31Bile duct proliferation (HP:0001408)2.53132559
32Postaxial foot polydactyly (HP:0001830)2.51470440
33Tubular atrophy (HP:0000092)2.48326254
34Chronic otitis media (HP:0000389)2.37161069
35Congenital primary aphakia (HP:0007707)2.32012159
36Chronic hepatic failure (HP:0100626)2.30747509
37Recurrent sinusitis (HP:0011108)2.24542662
38Gait imbalance (HP:0002141)2.23786242
39Bifid tongue (HP:0010297)2.17008344
40Bell-shaped thorax (HP:0001591)2.15659490
41Congenital hepatic fibrosis (HP:0002612)2.12901781
42Abnormality of dentin (HP:0010299)2.09795475
43Genital tract atresia (HP:0001827)2.07021729
44Cortical dysplasia (HP:0002539)2.06279925
45Abnormality of the fovea (HP:0000493)2.05940487
46Abdominal situs inversus (HP:0003363)2.04852120
47Abnormality of abdominal situs (HP:0011620)2.04852120
48Anencephaly (HP:0002323)2.04267976
49Abnormality of macular pigmentation (HP:0008002)2.03770082
50Sclerocornea (HP:0000647)2.03423827
51Respiratory insufficiency due to defective ciliary clearance (HP:0200073)13.6154724
52Abnormal respiratory motile cilium physiology (HP:0012261)10.5787754
53Tubulointerstitial abnormality (HP:0001969)1.98853273
54Nephrogenic diabetes insipidus (HP:0009806)1.98806424
55Postaxial hand polydactyly (HP:0001162)1.96967018
56Male pseudohermaphroditism (HP:0000037)1.95977082
57Oculomotor apraxia (HP:0000657)1.95975762
58Secondary amenorrhea (HP:0000869)1.91328845
59Poor coordination (HP:0002370)1.86425171
60Hyperactive renin-angiotensin system (HP:0000841)1.84236105
61Vaginal atresia (HP:0000148)1.83137140
62Chromsome breakage (HP:0040012)1.83018764
63Insulin-resistant diabetes mellitus (HP:0000831)1.81645240
64Aplasia/Hypoplasia of the lens (HP:0008063)1.80590509
65Preaxial hand polydactyly (HP:0001177)1.79412118
66Chromosomal breakage induced by crosslinking agents (HP:0003221)1.76774450
67Median cleft lip (HP:0000161)1.76091859
68Atelectasis (HP:0100750)1.74193558
69Breast hypoplasia (HP:0003187)1.73913980
70Microglossia (HP:0000171)1.73134387
71Abnormal spermatogenesis (HP:0008669)1.72441056
72Abnormality of the renal cortex (HP:0011035)1.71716945
73Flat capital femoral epiphysis (HP:0003370)1.67549482
74Abnormal gallbladder physiology (HP:0012438)1.66684304
75Cholecystitis (HP:0001082)1.66684304
76Abnormality of lateral ventricle (HP:0030047)1.64589440
77Fibular hypoplasia (HP:0003038)1.62681651
78Premature ovarian failure (HP:0008209)1.59060519
79Recurrent bronchitis (HP:0002837)1.58256570
80Adrenal hypoplasia (HP:0000835)1.53228056
81Nephropathy (HP:0000112)1.53004428
82Furrowed tongue (HP:0000221)1.50547760
83Stage 5 chronic kidney disease (HP:0003774)1.50226285
84Facial hemangioma (HP:0000329)1.48049733
85Patellar aplasia (HP:0006443)1.47926311
86Anophthalmia (HP:0000528)1.47481385
87Abnormal drinking behavior (HP:0030082)1.45973727
88Polydipsia (HP:0001959)1.45973727
89Aplasia/Hypoplasia of the sternum (HP:0006714)1.45625790
90Abnormality of the labia minora (HP:0012880)1.45507175
91Sloping forehead (HP:0000340)1.45371830
92Narrow forehead (HP:0000341)1.44118148
93Shawl scrotum (HP:0000049)1.42545925
94Oligodactyly (hands) (HP:0001180)1.42340319
95Hypergonadotropic hypogonadism (HP:0000815)1.41469725
96Aplasia/Hypoplasia of the fibula (HP:0006492)1.40876180
97Aganglionic megacolon (HP:0002251)1.40097820
98Renal dysplasia (HP:0000110)1.39850862
99Cone-rod dystrophy (HP:0000548)1.37845097
100Broad foot (HP:0001769)1.37179968
101Intellectual disability, moderate (HP:0002342)1.37076014
102Hyperkalemia (HP:0002153)1.36047282
103Abnormality of the dental root (HP:0006486)1.35764706
104Taurodontia (HP:0000679)1.35764706
105Abnormality of permanent molar morphology (HP:0011071)1.35764706
106Tubulointerstitial fibrosis (HP:0005576)1.35613130
107Multicystic kidney dysplasia (HP:0000003)1.35371807
108Abnormality of the dental pulp (HP:0006479)1.35216582
109Long toe (HP:0010511)1.34364073
110Primary amenorrhea (HP:0000786)1.33608746
111Birth length less than 3rd percentile (HP:0003561)1.33199770
112Polyuria (HP:0000103)1.32543949
113Portal hypertension (HP:0001409)1.26540564
114Prominent nasal bridge (HP:0000426)1.25263211
115Progressive cerebellar ataxia (HP:0002073)1.22423188
116Decreased central vision (HP:0007663)1.21979944
117Optic nerve coloboma (HP:0000588)1.20496696
118Abnormality of renal excretion (HP:0011036)1.17397778
119Abnormal urine output (HP:0012590)1.17094313
120Specific learning disability (HP:0001328)1.17072924
121Renal salt wasting (HP:0000127)1.15462738
122Short nail (HP:0001799)1.14497950
123Abnormality of the hepatic vasculature (HP:0006707)1.13856227
124Holoprosencephaly (HP:0001360)1.12412412
125Abnormal rod and cone electroretinograms (HP:0008323)1.12003673
126Retinitis pigmentosa (HP:0000510)1.08240188
127Aplasia/Hypoplasia of the spleen (HP:0010451)1.07583879
128Asplenia (HP:0001746)1.05938176
129Decreased circulating renin level (HP:0003351)1.04924778
130Short thorax (HP:0010306)1.04820353
131Absent frontal sinuses (HP:0002688)1.04225899
132Highly arched eyebrow (HP:0002553)1.02691078
133Hyperaldosteronism (HP:0000859)1.02556604
134Esophageal atresia (HP:0002032)1.02198546

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK33.61338087
2PDK43.61338087
3MAP3K63.53251416
4LATS13.43401787
5MUSK3.37178757
6PRKD33.21006114
7PLK43.10489918
8CASK2.96454709
9STK38L2.86704834
10ERBB42.84837169
11PNCK2.78501975
12BRAF2.76398645
13TTK2.60458937
14TAOK32.59874395
15MAPK152.57240435
16MST42.54633299
17LATS22.52598224
18EEF2K2.36601835
19KSR22.34637683
20INSRR2.19809853
21ARAF2.17959805
22MOS2.17446228
23PINK12.15677845
24PDK22.05198211
25EPHA22.03154401
26TSSK61.83128300
27CDC71.66182903
28MAP3K91.63548390
29CDK81.59856972
30CHEK21.52996425
31MAP3K41.48655576
32STK31.47909327
33RAF11.46070166
34NEK21.45425315
35TESK11.41528026
36MAPKAPK31.39953182
37DMPK1.37280965
38MAP4K21.36565014
39MAP2K71.31525821
40MAPK131.30147903
41TLK11.28108861
42BMPR21.27469194
43MELK1.25563835
44EPHA41.22476492
45DYRK21.21515671
46CDK91.15454980
47BRSK21.14785272
48PLK11.11405314
49STK381.10973541
50BRD41.09661750
51ADRBK21.09412290
52DYRK31.08260733
53NTRK21.00601897
54MAP3K20.98158454
55STK100.94057941
56MAP3K130.93225556
57KSR10.89700680
58BMPR1B0.89078056
59NTRK30.88482686
60WNK30.87551684
61CDK30.85870541
62VRK10.85136187
63NME10.85072847
64MAPKAPK50.83963136
65PAK60.82941309
66BCR0.82688065
67WNK40.81551145
68WEE10.81499501
69ICK0.77626854
70PLK30.75415817
71RPS6KA40.74201034
72AURKA0.72945049
73TYRO30.68727756
74EPHB20.68313935
75PLK20.63597840
76MAP2K40.61155463
77MET0.60648506
78CAMK1G0.58598729
79NEK90.56333330
80TAOK10.55914238
81ERBB20.55270984
82PTK2B0.54913134
83PASK0.51973816
84PRKAA10.50889091
85AURKB0.49110429
86DDR20.49003676
87PRKCQ0.48768922
88MAP3K80.48191855
89ATM0.47885507
90PRKAA20.46997752
91CHEK10.46672313
92NUAK10.46610962
93MST1R0.45199419
94PRKD20.43729063
95ROCK10.42829745
96UHMK10.42447895
97MARK30.42198104
98HIPK20.42166173
99ERBB30.41268248
100PRKCG0.39423944
101SGK20.38564122
102STK390.38291071
103ACVR1B0.38101796
104TRPM70.37644886
105MARK20.37199690
106CAMK2A0.36575378
107MAP3K50.35841004
108SGK10.35569471
109STK160.34390208
110RPS6KA50.34259341
111PRKG10.33665215
112DYRK1B0.33229392
113CSNK1G10.32771468
114MAP3K70.32119909
115DYRK1A0.32022700
116GRK10.31620015
117PRKCZ0.31456714
118CSK0.30913585
119PKN10.30739525
120BUB10.30258396
121PRKACA0.29975615
122CAMKK10.28522994
123STK240.28256754
124IRAK10.28252058
125PRKCE0.27295375
126FRK0.26743454
127LRRK20.26612030
128RET0.26350325
129MINK10.25885994
130MARK10.25843403
131CDK10.25332041
132ROCK20.25227784
133PBK0.24598954
134ADRBK10.24486947
135FGR0.23326254
136TIE10.22993545
137SGK2230.22825261
138SGK4940.22825261
139CAMK2G0.22278703
140PAK10.21884565
141SRPK10.21080961
142CSNK1G30.20267912
143PDK10.20193925
144CDK50.20049165
145AKT20.18874015
146CSNK1G20.18726821
147NTRK10.18591356
148OXSR10.17236460
149CCNB10.17220939
150CDK150.16922092
151BRSK10.16456604
152CDK180.16158213
153MAP2K10.15767551
154CDK20.15478871
155PAK30.14230858
156NEK60.14058573
157NLK0.13013096

Predicted pathways (KEGG)

RankGene SetZ-score
1Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009804.08751764
2Vitamin B6 metabolism_Homo sapiens_hsa007503.98823969
3Basal transcription factors_Homo sapiens_hsa030223.81997106
4Cell cycle_Homo sapiens_hsa041103.43605706
5Histidine metabolism_Homo sapiens_hsa003403.35381488
6Phenylalanine metabolism_Homo sapiens_hsa003603.33664945
7Chemical carcinogenesis_Homo sapiens_hsa052043.31973730
8RNA degradation_Homo sapiens_hsa030183.09753331
9Linoleic acid metabolism_Homo sapiens_hsa005912.80716070
10alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.76218524
11Ovarian steroidogenesis_Homo sapiens_hsa049132.73626241
12Tyrosine metabolism_Homo sapiens_hsa003502.63796449
13Circadian rhythm_Homo sapiens_hsa047102.57298175
14Oocyte meiosis_Homo sapiens_hsa041142.55227071
15Dorso-ventral axis formation_Homo sapiens_hsa043202.40642020
16Progesterone-mediated oocyte maturation_Homo sapiens_hsa049142.37748046
17beta-Alanine metabolism_Homo sapiens_hsa004102.37543348
18Ether lipid metabolism_Homo sapiens_hsa005652.21921311
19Fanconi anemia pathway_Homo sapiens_hsa034602.17374387
20Glutathione metabolism_Homo sapiens_hsa004802.05431187
21Maturity onset diabetes of the young_Homo sapiens_hsa049501.92857882
22Pyruvate metabolism_Homo sapiens_hsa006201.91051615
23Propanoate metabolism_Homo sapiens_hsa006401.83432119
24Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.76237807
25Butanoate metabolism_Homo sapiens_hsa006501.74511605
26Retinol metabolism_Homo sapiens_hsa008301.68540284
27Basal cell carcinoma_Homo sapiens_hsa052171.65391630
28Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.65377546
29Protein export_Homo sapiens_hsa030601.64631941
30RNA transport_Homo sapiens_hsa030131.61261810
31Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.59184255
32Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.58466298
33Homologous recombination_Homo sapiens_hsa034401.54632751
34Fatty acid degradation_Homo sapiens_hsa000711.49611772
35Caffeine metabolism_Homo sapiens_hsa002321.48912389
36Primary bile acid biosynthesis_Homo sapiens_hsa001201.48085037
37Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.47990663
38Glucagon signaling pathway_Homo sapiens_hsa049221.41297889
39Glycerophospholipid metabolism_Homo sapiens_hsa005641.33848694
40mRNA surveillance pathway_Homo sapiens_hsa030151.33499472
41Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.28960099
42Salivary secretion_Homo sapiens_hsa049701.25068494
43Purine metabolism_Homo sapiens_hsa002301.24736922
44Huntingtons disease_Homo sapiens_hsa050161.24483154
45TGF-beta signaling pathway_Homo sapiens_hsa043501.22982471
46ABC transporters_Homo sapiens_hsa020101.22683144
47Nucleotide excision repair_Homo sapiens_hsa034201.22639761
48Nitrogen metabolism_Homo sapiens_hsa009101.21803457
49Peroxisome_Homo sapiens_hsa041461.21493011
50Steroid biosynthesis_Homo sapiens_hsa001001.18414606
51Steroid hormone biosynthesis_Homo sapiens_hsa001401.12808076
52PPAR signaling pathway_Homo sapiens_hsa033201.11748245
53Pancreatic cancer_Homo sapiens_hsa052121.10554004
54Base excision repair_Homo sapiens_hsa034101.09719875
55p53 signaling pathway_Homo sapiens_hsa041151.08965685
56Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.07972166
57Amphetamine addiction_Homo sapiens_hsa050311.07497017
58GnRH signaling pathway_Homo sapiens_hsa049121.07272777
59Phototransduction_Homo sapiens_hsa047441.06351315
60Fatty acid biosynthesis_Homo sapiens_hsa000611.03178464
61Cocaine addiction_Homo sapiens_hsa050301.02146569
62Estrogen signaling pathway_Homo sapiens_hsa049151.00998100
63Colorectal cancer_Homo sapiens_hsa052100.97283529
64Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.96552640
65Hedgehog signaling pathway_Homo sapiens_hsa043400.95601382
66Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.93576610
67Cysteine and methionine metabolism_Homo sapiens_hsa002700.92392613
68Insulin secretion_Homo sapiens_hsa049110.89706836
69Non-homologous end-joining_Homo sapiens_hsa034500.88412091
70Sulfur metabolism_Homo sapiens_hsa009200.87385932
71Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.85704718
72Arachidonic acid metabolism_Homo sapiens_hsa005900.85650339
73Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.85399462
74Pyrimidine metabolism_Homo sapiens_hsa002400.79353799
75Serotonergic synapse_Homo sapiens_hsa047260.77391851
76Sphingolipid metabolism_Homo sapiens_hsa006000.76939814
77Prolactin signaling pathway_Homo sapiens_hsa049170.75475899
78Tryptophan metabolism_Homo sapiens_hsa003800.75356882
79GABAergic synapse_Homo sapiens_hsa047270.75235616
80Mismatch repair_Homo sapiens_hsa034300.74444771
81Choline metabolism in cancer_Homo sapiens_hsa052310.73782810
82Systemic lupus erythematosus_Homo sapiens_hsa053220.71523493
83Hippo signaling pathway_Homo sapiens_hsa043900.71495365
84Long-term depression_Homo sapiens_hsa047300.71200310
85Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.70811013
86Glutamatergic synapse_Homo sapiens_hsa047240.68836924
87Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.67759767
88Arginine and proline metabolism_Homo sapiens_hsa003300.67599706
89Notch signaling pathway_Homo sapiens_hsa043300.63255559
90Selenocompound metabolism_Homo sapiens_hsa004500.62778836
91Calcium signaling pathway_Homo sapiens_hsa040200.61299990
92Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.61234591
93Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.60672152
94RNA polymerase_Homo sapiens_hsa030200.59634298
95Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.59582964
96Cardiac muscle contraction_Homo sapiens_hsa042600.59565705
97Olfactory transduction_Homo sapiens_hsa047400.58846264
98Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.57500748
99Gap junction_Homo sapiens_hsa045400.57021342
100Wnt signaling pathway_Homo sapiens_hsa043100.56272887
101cAMP signaling pathway_Homo sapiens_hsa040240.55876360
102Inositol phosphate metabolism_Homo sapiens_hsa005620.53856337
103Renal cell carcinoma_Homo sapiens_hsa052110.53630957
104Long-term potentiation_Homo sapiens_hsa047200.52373588
105DNA replication_Homo sapiens_hsa030300.51646529
106Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.51457935
107MicroRNAs in cancer_Homo sapiens_hsa052060.50753548
108Synaptic vesicle cycle_Homo sapiens_hsa047210.50184505
109Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.50170637
110Gastric acid secretion_Homo sapiens_hsa049710.50145585
111Axon guidance_Homo sapiens_hsa043600.49799794
112Dopaminergic synapse_Homo sapiens_hsa047280.49743952
113Metabolic pathways_Homo sapiens_hsa011000.49297080
114Ras signaling pathway_Homo sapiens_hsa040140.48464324
115Circadian entrainment_Homo sapiens_hsa047130.48119342
116Vascular smooth muscle contraction_Homo sapiens_hsa042700.47961115
117VEGF signaling pathway_Homo sapiens_hsa043700.46346340
118Collecting duct acid secretion_Homo sapiens_hsa049660.46333994
119Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.46286137
120cGMP-PKG signaling pathway_Homo sapiens_hsa040220.45876665
121Morphine addiction_Homo sapiens_hsa050320.45588247
122AMPK signaling pathway_Homo sapiens_hsa041520.44798120
123Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.44687855
124Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.43770564
125Glycerolipid metabolism_Homo sapiens_hsa005610.43204895
126Carbohydrate digestion and absorption_Homo sapiens_hsa049730.42576248
127Tight junction_Homo sapiens_hsa045300.42423482
128Bile secretion_Homo sapiens_hsa049760.41575104
129Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.40716130
130Longevity regulating pathway - mammal_Homo sapiens_hsa042110.40444141
131Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.39968276
132FoxO signaling pathway_Homo sapiens_hsa040680.39569338
133Phosphatidylinositol signaling system_Homo sapiens_hsa040700.38618114
134Adherens junction_Homo sapiens_hsa045200.38045748
135Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.36646833
136Starch and sucrose metabolism_Homo sapiens_hsa005000.35211213
137Viral carcinogenesis_Homo sapiens_hsa052030.34318035
138Nicotine addiction_Homo sapiens_hsa050330.33845275
139Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.33621936
140Thyroid hormone signaling pathway_Homo sapiens_hsa049190.33046954
141Transcriptional misregulation in cancer_Homo sapiens_hsa052020.32424603
142Pancreatic secretion_Homo sapiens_hsa049720.31428873
143Melanogenesis_Homo sapiens_hsa049160.31072212
144HTLV-I infection_Homo sapiens_hsa051660.31023628
145Arginine biosynthesis_Homo sapiens_hsa002200.30654821
146Epstein-Barr virus infection_Homo sapiens_hsa051690.30052717
147Taste transduction_Homo sapiens_hsa047420.29162762
148Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.28286961
149Vibrio cholerae infection_Homo sapiens_hsa051100.27488735
150Renin secretion_Homo sapiens_hsa049240.26767612
151Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.26538392
152Thyroid hormone synthesis_Homo sapiens_hsa049180.26445474
153Endometrial cancer_Homo sapiens_hsa052130.26238626
154Alcoholism_Homo sapiens_hsa050340.26017332
155Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.25810205
156MAPK signaling pathway_Homo sapiens_hsa040100.25537836
157Other glycan degradation_Homo sapiens_hsa005110.24688665
158Oxytocin signaling pathway_Homo sapiens_hsa049210.23437235
159Pentose and glucuronate interconversions_Homo sapiens_hsa000400.22469355
160Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.21944665
161Oxidative phosphorylation_Homo sapiens_hsa001900.21699975

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