TEX19

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synapsis (GO:0007129)6.70210408
2DNA synthesis involved in DNA repair (GO:0000731)6.50940626
3mitotic chromosome condensation (GO:0007076)6.37803398
4chromosome organization involved in meiosis (GO:0070192)6.26664625
5synaptonemal complex assembly (GO:0007130)6.04150989
6piRNA metabolic process (GO:0034587)5.79760987
7male meiosis I (GO:0007141)5.55448751
8negative regulation of retinoic acid receptor signaling pathway (GO:0048387)5.40062794
9nuclear pore complex assembly (GO:0051292)5.39618242
10synaptonemal complex organization (GO:0070193)5.23500011
11protein localization to chromosome, centromeric region (GO:0071459)4.95897423
12nuclear pore organization (GO:0006999)4.87057673
13meiosis I (GO:0007127)4.79665438
14DNA unwinding involved in DNA replication (GO:0006268)4.74577475
15regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)4.72410207
16DNA replication initiation (GO:0006270)4.69074458
17mitotic sister chromatid segregation (GO:0000070)4.63071240
18regulation of retinoic acid receptor signaling pathway (GO:0048385)4.57949694
19DNA strand elongation involved in DNA replication (GO:0006271)4.56514947
20DNA strand elongation (GO:0022616)4.54396311
21meiotic chromosome segregation (GO:0045132)4.50625420
22mitotic metaphase plate congression (GO:0007080)4.47126710
23meiotic nuclear division (GO:0007126)4.40175047
24meiotic cell cycle process (GO:1903046)4.39342419
25positive regulation of chromosome segregation (GO:0051984)4.30195365
26regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.29282009
27DNA methylation involved in gamete generation (GO:0043046)4.24637166
28sister chromatid cohesion (GO:0007062)4.24535596
29sister chromatid segregation (GO:0000819)4.23524434
30mitotic sister chromatid cohesion (GO:0007064)4.21699997
31male meiosis (GO:0007140)4.08400467
32telomere maintenance via semi-conservative replication (GO:0032201)4.07260335
33DNA replication checkpoint (GO:0000076)4.06354850
34mitotic nuclear envelope disassembly (GO:0007077)4.05756971
35attachment of spindle microtubules to kinetochore (GO:0008608)3.98472797
36protein localization to chromosome (GO:0034502)3.97322811
37regulation of translational fidelity (GO:0006450)3.95854425
38pore complex assembly (GO:0046931)3.90589905
39positive regulation of mitotic sister chromatid separation (GO:1901970)3.89920373
40positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.89920373
41positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.89920373
42formation of translation preinitiation complex (GO:0001731)3.88869049
43regulation of histone H3-K9 methylation (GO:0051570)3.88225408
44nuclear envelope disassembly (GO:0051081)3.85599760
45membrane disassembly (GO:0030397)3.85599760
46regulation of sister chromatid cohesion (GO:0007063)3.85476494
47protein localization to kinetochore (GO:0034501)3.82115819
48chromosome condensation (GO:0030261)3.70068100
49regulation of meiosis I (GO:0060631)3.69272880
50DNA packaging (GO:0006323)3.68851524
51regulation of RNA export from nucleus (GO:0046831)3.64772385
52metaphase plate congression (GO:0051310)3.58763120
53ribosomal small subunit biogenesis (GO:0042274)3.56634976
54regulation of spindle organization (GO:0090224)3.45955812
55DNA replication-dependent nucleosome assembly (GO:0006335)3.44203136
56DNA replication-dependent nucleosome organization (GO:0034723)3.44203136
57gene silencing by RNA (GO:0031047)3.44065718
58ribosome biogenesis (GO:0042254)3.43961042
59regulation of chromosome segregation (GO:0051983)3.43114788
60telomere maintenance via recombination (GO:0000722)3.35323483
61CENP-A containing nucleosome assembly (GO:0034080)3.33886904
62chromosome segregation (GO:0007059)3.25858313
63chromosome organization (GO:0051276)3.24134459
64ribonucleoprotein complex biogenesis (GO:0022613)3.23676956
65resolution of meiotic recombination intermediates (GO:0000712)3.20761205
66mitotic recombination (GO:0006312)3.18939519
67DNA biosynthetic process (GO:0071897)3.17160596
68transcription from mitochondrial promoter (GO:0006390)3.16025713
69chromatin remodeling at centromere (GO:0031055)3.14210543
70reciprocal DNA recombination (GO:0035825)3.14025223
71reciprocal meiotic recombination (GO:0007131)3.14025223
72establishment of chromosome localization (GO:0051303)3.13437599
73histone exchange (GO:0043486)3.13015117
74negative regulation of chromosome segregation (GO:0051985)3.12047897
75DNA conformation change (GO:0071103)3.11558406
76establishment of integrated proviral latency (GO:0075713)3.09225652
77mitotic spindle checkpoint (GO:0071174)3.07729879
78nuclear envelope organization (GO:0006998)3.04951108
79DNA replication-independent nucleosome assembly (GO:0006336)3.03040222
80DNA replication-independent nucleosome organization (GO:0034724)3.03040222
81regulation of chromatin binding (GO:0035561)3.02356399
82gonadal mesoderm development (GO:0007506)3.01815761
83chromatin assembly or disassembly (GO:0006333)3.01539526
84nucleotide-excision repair, DNA gap filling (GO:0006297)2.99950621
85spindle checkpoint (GO:0031577)2.99706446
86regulation of mitotic spindle organization (GO:0060236)2.98104988
87DNA topological change (GO:0006265)2.96866992
88DNA duplex unwinding (GO:0032508)2.95246710
89regulation of DNA endoreduplication (GO:0032875)2.94111592
90telomere maintenance via telomere lengthening (GO:0010833)2.94096986
91regulation of mitotic sister chromatid separation (GO:0010965)2.93343753
92regulation of mitotic sister chromatid segregation (GO:0033047)2.93343753
93regulation of sister chromatid segregation (GO:0033045)2.93343753
94spliceosomal tri-snRNP complex assembly (GO:0000244)2.93319107
95mitotic spindle assembly checkpoint (GO:0007094)2.92241772
96negative regulation of sister chromatid segregation (GO:0033046)2.91216111
97negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.91216111
98negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.91216111
99negative regulation of mitotic sister chromatid segregation (GO:0033048)2.91216111
100negative regulation of mitotic sister chromatid separation (GO:2000816)2.91216111

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.00307975
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.64900406
3MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse4.26374740
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.70660042
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.65547730
6FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.59321056
7HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.28951185
8EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.98555833
9KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.79603016
10MYC_19079543_ChIP-ChIP_MESCs_Mouse2.67256250
11MYC_18358816_ChIP-ChIP_MESCs_Mouse2.60556945
12CREB1_15753290_ChIP-ChIP_HEK293T_Human2.51174360
13MYC_19030024_ChIP-ChIP_MESCs_Mouse2.49921476
14JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.41610852
15XRN2_22483619_ChIP-Seq_HELA_Human2.31615399
16ETS1_20019798_ChIP-Seq_JURKAT_Human2.28274588
17TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.22585735
18E2F1_21310950_ChIP-Seq_MCF-7_Human2.21022302
19AR_21909140_ChIP-Seq_LNCAP_Human2.20885134
20POU5F1_18555785_ChIP-Seq_MESCs_Mouse2.20855841
21THAP11_20581084_ChIP-Seq_MESCs_Mouse2.16456153
22DCP1A_22483619_ChIP-Seq_HELA_Human2.15782656
23EST1_17652178_ChIP-ChIP_JURKAT_Human2.05714482
24* MYC_22102868_ChIP-Seq_BL_Human2.05374280
25* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.03215381
26EGR1_19374776_ChIP-ChIP_THP-1_Human1.95826729
27ZFX_18555785_ChIP-Seq_MESCs_Mouse1.95203836
28TTF2_22483619_ChIP-Seq_HELA_Human1.92237426
29NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.90923174
30MYCN_18555785_ChIP-Seq_MESCs_Mouse1.89905365
31GABP_19822575_ChIP-Seq_HepG2_Human1.82496263
32KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.78240221
33DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.77128464
34PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.76304506
35GABP_17652178_ChIP-ChIP_JURKAT_Human1.70250197
36CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.69060137
37KDM5A_27292631_Chip-Seq_BREAST_Human1.67100765
38FOXP3_21729870_ChIP-Seq_TREG_Human1.66087321
39CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.65225361
40NOTCH1_21737748_ChIP-Seq_TLL_Human1.64963591
41CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.62251445
42YY1_21170310_ChIP-Seq_MESCs_Mouse1.57920603
43ZNF263_19887448_ChIP-Seq_K562_Human1.55227204
44CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.54925861
45* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.54663736
46CIITA_25753668_ChIP-Seq_RAJI_Human1.53293660
47MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.51838941
48VDR_23849224_ChIP-Seq_CD4+_Human1.49384532
49ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.48018446
50YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.44534656
51MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.41072486
52TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.38830447
53CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.38401722
54NANOG_18555785_ChIP-Seq_MESCs_Mouse1.37793711
55KLF4_18555785_ChIP-Seq_MESCs_Mouse1.37516383
56VDR_21846776_ChIP-Seq_THP-1_Human1.37400718
57FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.37030833
58E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.34267915
59E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.32923958
60ERG_20887958_ChIP-Seq_HPC-7_Mouse1.30174654
61TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.29055781
62ELF1_17652178_ChIP-ChIP_JURKAT_Human1.27715643
63TP63_19390658_ChIP-ChIP_HaCaT_Human1.25496421
64ESR1_15608294_ChIP-ChIP_MCF-7_Human1.19559405
65HOXB4_20404135_ChIP-ChIP_EML_Mouse1.18649068
66CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.12534366
67SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.12084068
68SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.12029305
69ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.11924569
70PADI4_21655091_ChIP-ChIP_MCF-7_Human1.09490534
71PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.07013673
72PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.06944066
73TFEB_21752829_ChIP-Seq_HELA_Human1.02868411
74STAT3_1855785_ChIP-Seq_MESCs_Mouse1.02338192
75HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.00312676
76SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.99332274
77SRF_21415370_ChIP-Seq_HL-1_Mouse0.98435097
78BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.94635279
79SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.94411464
80NCOR1_26117541_ChIP-Seq_K562_Human0.90689932
81GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.90226492
82PKCTHETA_26484144_Chip-Seq_BREAST_Human0.89114393
83CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.87617716
84KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.84348388
85KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.84348388
86KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.84348388
87TBX5_21415370_ChIP-Seq_HL-1_Mouse0.83647574
88P68_20966046_ChIP-Seq_HELA_Human0.83413962
89HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.82429787
90* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.82115961
91POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.82016840
92CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.81078092
93SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.79351838
94FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.78725234
95TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.78601503
96SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.77968602
97CHD1_26751641_Chip-Seq_LNCaP_Human0.77911373
98ELK1_19687146_ChIP-ChIP_HELA_Human0.76270082
99NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.76156763
100SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.75883755

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.18792950
2MP0010094_abnormal_chromosome_stability4.87682496
3MP0003111_abnormal_nucleus_morphology4.81027552
4MP0008058_abnormal_DNA_repair4.32009949
5MP0004957_abnormal_blastocyst_morpholog3.96223365
6MP0003077_abnormal_cell_cycle3.80100639
7MP0008057_abnormal_DNA_replication3.76710401
8MP0008877_abnormal_DNA_methylation3.58739419
9MP0003718_maternal_effect2.88062885
10MP0002210_abnormal_sex_determination2.66686478
11MP0008932_abnormal_embryonic_tissue2.46317865
12MP0001929_abnormal_gametogenesis2.41896639
13MP0001730_embryonic_growth_arrest2.39270652
14MP0010307_abnormal_tumor_latency2.34904324
15MP0008007_abnormal_cellular_replicative2.24883289
16MP0000350_abnormal_cell_proliferation2.11141032
17MP0001145_abnormal_male_reproductive1.91482109
18MP0001672_abnormal_embryogenesis/_devel1.84209418
19MP0005380_embryogenesis_phenotype1.84209418
20MP0002160_abnormal_reproductive_system1.81455671
21MP0005076_abnormal_cell_differentiation1.80998162
22MP0000653_abnormal_sex_gland1.77568365
23MP0005451_abnormal_body_composition1.75193719
24MP0001986_abnormal_taste_sensitivity1.71592119
25MP0001697_abnormal_embryo_size1.71068942
26MP0003786_premature_aging1.71062548
27MP0003699_abnormal_female_reproductive1.70465805
28MP0003698_abnormal_male_reproductive1.61155407
29MP0003984_embryonic_growth_retardation1.58341797
30MP0002080_prenatal_lethality1.57217473
31MP0000313_abnormal_cell_death1.54933377
32MP0002877_abnormal_melanocyte_morpholog1.51811598
33MP0000678_abnormal_parathyroid_gland1.51297646
34MP0002088_abnormal_embryonic_growth/wei1.51213221
35MP0006035_abnormal_mitochondrial_morpho1.45619866
36MP0004233_abnormal_muscle_weight1.43006450
37MP0008995_early_reproductive_senescence1.42659337
38MP0002396_abnormal_hematopoietic_system1.40389978
39MP0005423_abnormal_somatic_nervous1.39433469
40MP0002161_abnormal_fertility/fecundity1.39188653
41MP0001119_abnormal_female_reproductive1.33956429
42MP0002009_preneoplasia1.33222923
43MP0001346_abnormal_lacrimal_gland1.31151339
44MP0008260_abnormal_autophagy1.28381052
45MP0009333_abnormal_splenocyte_physiolog1.27769893
46MP0002085_abnormal_embryonic_tissue1.20317464
47MP0000490_abnormal_crypts_of1.19723414
48MP0002086_abnormal_extraembryonic_tissu1.16508608
49MP0004185_abnormal_adipocyte_glucose1.14838121
50MP0009697_abnormal_copulation1.12339813
51MP0000358_abnormal_cell_content/1.08981056
52MP0002084_abnormal_developmental_patter1.08593325
53MP0005389_reproductive_system_phenotype1.07967153
54MP0009379_abnormal_foot_pigmentation1.07402081
55MP0000703_abnormal_thymus_morphology1.07128723
56MP0006292_abnormal_olfactory_placode1.04265519
57MP0005501_abnormal_skin_physiology1.03918350
58MP0009672_abnormal_birth_weight1.00841243
59MP0004197_abnormal_fetal_growth/weight/0.99464038
60MP0002019_abnormal_tumor_incidence0.99127521
61MP0001661_extended_life_span0.96646680
62MP0004264_abnormal_extraembryonic_tissu0.94543045
63MP0010234_abnormal_vibrissa_follicle0.93344809
64MP0006036_abnormal_mitochondrial_physio0.92463294
65MP0004808_abnormal_hematopoietic_stem0.91556711
66MP0005410_abnormal_fertilization0.84994064
67MP0002796_impaired_skin_barrier0.84236815
68MP0002163_abnormal_gland_morphology0.84226822
69MP0003943_abnormal_hepatobiliary_system0.80650961
70MP0005395_other_phenotype0.80316154
71MP0003890_abnormal_embryonic-extraembry0.80109335
72MP0003763_abnormal_thymus_physiology0.79553014
73MP0003315_abnormal_perineum_morphology0.79423512
74MP0005384_cellular_phenotype0.77020226
75MP0008789_abnormal_olfactory_epithelium0.75566248
76MP0010030_abnormal_orbit_morphology0.75107286
77MP0001348_abnormal_lacrimal_gland0.70571729
78MP0002166_altered_tumor_susceptibility0.69487166
79MP0003123_paternal_imprinting0.69433896
80MP0005621_abnormal_cell_physiology0.69116333
81MP0005499_abnormal_olfactory_system0.66519360
82MP0005394_taste/olfaction_phenotype0.66519360
83MP0009840_abnormal_foam_cell0.65453975
84MP0002006_tumorigenesis0.65340778
85MP0004381_abnormal_hair_follicle0.62543376
86MP0000566_synostosis0.62434800
87MP0001666_abnormal_nutrient_absorption0.61637668
88MP0003941_abnormal_skin_development0.61538139
89MP0001919_abnormal_reproductive_system0.61190709
90MP0005058_abnormal_lysosome_morphology0.61063387
91MP0002269_muscular_atrophy0.59984816
92MP0009703_decreased_birth_body0.58112790
93MP0002398_abnormal_bone_marrow0.57274308
94MP0001881_abnormal_mammary_gland0.57028900
95MP0004782_abnormal_surfactant_physiolog0.56508548
96MP0003959_abnormal_lean_body0.56140778
97MP0002722_abnormal_immune_system0.55625295
98MP0000015_abnormal_ear_pigmentation0.53360890
99MP0002089_abnormal_postnatal_growth/wei0.52355997
100MP0005409_darkened_coat_color0.50798337

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)5.73701915
2Chromsome breakage (HP:0040012)5.50128348
3Birth length less than 3rd percentile (HP:0003561)3.96621941
4Microvesicular hepatic steatosis (HP:0001414)3.95589022
5Progressive external ophthalmoplegia (HP:0000590)3.79197564
6Progressive muscle weakness (HP:0003323)3.71653684
7Reticulocytopenia (HP:0001896)3.51200224
8Premature ovarian failure (HP:0008209)3.40843597
9Increased nuchal translucency (HP:0010880)3.08712886
10Abnormality of cochlea (HP:0000375)3.01601633
11Abnormality of the preputium (HP:0100587)2.97299997
12Male infertility (HP:0003251)2.97263714
13Cholecystitis (HP:0001082)2.83880292
14Abnormal gallbladder physiology (HP:0012438)2.83880292
15Poikiloderma (HP:0001029)2.79338133
16Abnormality of chromosome stability (HP:0003220)2.75054907
17Nephroblastoma (Wilms tumor) (HP:0002667)2.74970008
18Aplasia/Hypoplasia of the uvula (HP:0010293)2.73918466
19Abnormality of glycolysis (HP:0004366)2.71944004
20Facial hemangioma (HP:0000329)2.70913491
21Ragged-red muscle fibers (HP:0003200)2.68040208
22Azoospermia (HP:0000027)2.67935233
23Truncus arteriosus (HP:0001660)2.66843778
24Meckel diverticulum (HP:0002245)2.63939374
25Small intestinal stenosis (HP:0012848)2.60115503
26Duodenal stenosis (HP:0100867)2.60115503
27Myelodysplasia (HP:0002863)2.57130397
28Squamous cell carcinoma (HP:0002860)2.56231979
29Testicular atrophy (HP:0000029)2.55859756
30Abnormality of chromosome segregation (HP:0002916)2.54685230
31Abnormality of DNA repair (HP:0003254)2.50827978
32Embryonal renal neoplasm (HP:0011794)2.48175447
33Abnormality of the ileum (HP:0001549)2.47425757
34Multiple enchondromatosis (HP:0005701)2.46190125
35Horseshoe kidney (HP:0000085)2.45503678
36Abnormal lung lobation (HP:0002101)2.44517069
37Spontaneous abortion (HP:0005268)2.44464955
38Aplasia/Hypoplasia of the sacrum (HP:0008517)2.43403458
39Ectopic kidney (HP:0000086)2.39665399
40Hypergonadotropic hypogonadism (HP:0000815)2.39028348
41Increased serum pyruvate (HP:0003542)2.35911068
42Abnormal spermatogenesis (HP:0008669)2.34670379
43Abnormality of reticulocytes (HP:0004312)2.30672058
44Absent radius (HP:0003974)2.29393772
45Upper limb muscle weakness (HP:0003484)2.26055352
46Abnormality of cells of the erythroid lineage (HP:0012130)2.25567515
47Absent thumb (HP:0009777)2.22495360
48Cafe-au-lait spot (HP:0000957)2.21454911
49Overlapping toe (HP:0001845)2.20978526
50Breast hypoplasia (HP:0003187)2.19003137
51Duplicated collecting system (HP:0000081)2.18417322
52Ankyloglossia (HP:0010296)2.15672248
53Ureteral duplication (HP:0000073)2.12878784
54Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.11887878
55Gonadotropin excess (HP:0000837)2.10811620
56Embryonal neoplasm (HP:0002898)2.10698633
57Aplasia involving forearm bones (HP:0009822)2.10237833
58Absent forearm bone (HP:0003953)2.10237833
59Heterotopia (HP:0002282)2.06731195
60Septate vagina (HP:0001153)2.06426479
6111 pairs of ribs (HP:0000878)2.05198257
62Impulsivity (HP:0100710)2.04594854
63Atresia of the external auditory canal (HP:0000413)2.00843779
64Gout (HP:0001997)2.00208628
65Proximal placement of thumb (HP:0009623)1.95866698
66Morphological abnormality of the inner ear (HP:0011390)1.94743153
67Dysmetric saccades (HP:0000641)1.94195657
68Abnormality of the renal collecting system (HP:0004742)1.92226516
69Abnormality of the carotid arteries (HP:0005344)1.89611124
70Abnormality of the duodenum (HP:0002246)1.89413244
71Abnormal number of erythroid precursors (HP:0012131)1.88850548
72Choanal atresia (HP:0000453)1.88572083
73Pallor (HP:0000980)1.85924832
74Dysphonia (HP:0001618)1.85515018
75Secondary amenorrhea (HP:0000869)1.85428461
76Impaired proprioception (HP:0010831)1.83852589
77Duplication of thumb phalanx (HP:0009942)1.82944781
78Prolonged partial thromboplastin time (HP:0003645)1.82901246
79Deviation of the thumb (HP:0009603)1.82898373
80Basal cell carcinoma (HP:0002671)1.82107950
81Combined immunodeficiency (HP:0005387)1.81403804
82External ophthalmoplegia (HP:0000544)1.81348068
83Vaginal fistula (HP:0004320)1.79844832
84Capillary hemangiomas (HP:0005306)1.78410782
85Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.77898150
86Short thumb (HP:0009778)1.76500375
87Abnormality of abdominal situs (HP:0011620)1.76345129
88Abdominal situs inversus (HP:0003363)1.76345129
89Entropion (HP:0000621)1.76285560
90Patellar aplasia (HP:0006443)1.76062117
91Trismus (HP:0000211)1.74861592
92Progressive hearing impairment (HP:0001730)1.74419901
93Sloping forehead (HP:0000340)1.73673683
94Reticulocytosis (HP:0001923)1.73579769
95Macrocytic anemia (HP:0001972)1.71224420
96Bowel incontinence (HP:0002607)1.70769676
97Hemorrhage of the eye (HP:0011885)1.70200597
98Arteriovenous malformation (HP:0100026)1.69742576
99Aplasia/Hypoplasia of the patella (HP:0006498)1.67838502
100Urethral obstruction (HP:0000796)1.66710805

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.51824558
2TTK3.49484609
3CDK123.15953303
4CDC73.02307556
5SMG13.00526615
6EEF2K2.76337293
7SRPK12.68493248
8ICK2.10477490
9CHEK22.00633182
10KSR21.91395742
11EIF2AK11.90060625
12TRIB31.82311341
13CDK71.80498540
14PBK1.77315153
15NEK11.76142155
16NME21.75274600
17BRSK11.74794784
18MAP3K101.73963982
19AURKA1.71427498
20PLK11.71032123
21PLK41.67306676
22WEE11.66967570
23VRK21.64001560
24TSSK61.63865125
25RPS6KB21.63747297
26PDK21.59864230
27SCYL21.57572457
28CHEK11.57046277
29MAP3K81.55904917
30NEK21.55152424
31CDK41.52867040
32BRAF1.52731370
33ATR1.51770301
34TAF11.35518821
35PRPF4B1.32750083
36EIF2AK31.32212916
37RAF11.31871661
38MAP3K131.31176953
39MAP3K91.31003190
40CDK81.30035567
41STK161.29230238
42AURKB1.28539532
43VRK11.28502019
44CDK191.27332062
45BRSK21.25904739
46NME11.24497900
47ARAF1.23987306
48PLK31.12128336
49MAPK111.07002448
50STK241.02249203
51TESK21.01876967
52NEK60.97838874
53CDK90.97294948
54MELK0.96303222
55CDK20.93369980
56ATM0.90841826
57CDK10.87076333
58PKN20.78349206
59LATS20.77255376
60CLK10.76801124
61STK40.76531076
62IRAK30.76461423
63MTOR0.75845252
64PRKCI0.75527999
65ZAK0.72435188
66BRD40.72276840
67CDK60.71056331
68CDK11A0.69252378
69STK100.69069313
70KSR10.68509092
71PIM10.65598817
72CCNB10.64370589
73AKT20.63236328
74PNCK0.63003907
75MAP3K20.62174877
76CDK150.57810069
77MAPKAPK50.56000316
78TAOK20.55345849
79TLK10.55054711
80STK30.54331561
81CDK30.53326166
82RPS6KB10.53263544
83FGFR40.53023720
84CDK180.50896549
85CSNK2A20.50423978
86CSNK1E0.48408549
87CDK140.47196421
88MAP3K140.47084564
89CSNK2A10.46889327
90PAK10.44793762
91NEK90.44002118
92PASK0.43079509
93BMX0.42767504
94EIF2AK20.42652146
95MARK30.41612100
96TYRO30.36289027
97GSK3B0.34351638
98ALK0.33644961
99LRRK20.33063530
100MAPK140.30942816

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030305.08276036
2Mismatch repair_Homo sapiens_hsa034303.87226450
3Cell cycle_Homo sapiens_hsa041103.67463128
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.36372033
5Base excision repair_Homo sapiens_hsa034103.32709831
6RNA transport_Homo sapiens_hsa030133.06031452
7Homologous recombination_Homo sapiens_hsa034402.95497549
8Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.73729286
9Nucleotide excision repair_Homo sapiens_hsa034202.69808779
10Spliceosome_Homo sapiens_hsa030402.57018699
11Non-homologous end-joining_Homo sapiens_hsa034502.53749198
12Ribosome_Homo sapiens_hsa030102.48127626
13mRNA surveillance pathway_Homo sapiens_hsa030152.38157368
14Basal transcription factors_Homo sapiens_hsa030222.30561409
15One carbon pool by folate_Homo sapiens_hsa006702.14559415
16Fanconi anemia pathway_Homo sapiens_hsa034602.14161189
17Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.84153368
18Oocyte meiosis_Homo sapiens_hsa041141.83580818
19RNA polymerase_Homo sapiens_hsa030201.77732490
20Pyrimidine metabolism_Homo sapiens_hsa002401.66925888
21Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.60951757
22RNA degradation_Homo sapiens_hsa030181.44586189
23Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.28011094
24Biosynthesis of amino acids_Homo sapiens_hsa012301.25929617
25p53 signaling pathway_Homo sapiens_hsa041151.25416833
26Thyroid cancer_Homo sapiens_hsa052161.23758598
27Cysteine and methionine metabolism_Homo sapiens_hsa002701.23603936
28Sulfur relay system_Homo sapiens_hsa041221.20746228
29Proteasome_Homo sapiens_hsa030501.17281535
30Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.16739439
31Viral carcinogenesis_Homo sapiens_hsa052031.12384230
32Pentose phosphate pathway_Homo sapiens_hsa000301.05402553
33Non-small cell lung cancer_Homo sapiens_hsa052231.04121121
34Selenocompound metabolism_Homo sapiens_hsa004501.03268023
352-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.02553910
36Central carbon metabolism in cancer_Homo sapiens_hsa052300.95435687
37Chronic myeloid leukemia_Homo sapiens_hsa052200.94279159
38Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.93296056
39Folate biosynthesis_Homo sapiens_hsa007900.92082904
40Pyruvate metabolism_Homo sapiens_hsa006200.91212274
41Purine metabolism_Homo sapiens_hsa002300.88596567
42Bladder cancer_Homo sapiens_hsa052190.87839870
43Carbon metabolism_Homo sapiens_hsa012000.87599160
44Epstein-Barr virus infection_Homo sapiens_hsa051690.86268875
45mTOR signaling pathway_Homo sapiens_hsa041500.84322175
46Pancreatic cancer_Homo sapiens_hsa052120.81206337
47Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.76144061
48Systemic lupus erythematosus_Homo sapiens_hsa053220.74734681
49HTLV-I infection_Homo sapiens_hsa051660.74103764
50Fructose and mannose metabolism_Homo sapiens_hsa000510.71034006
51Acute myeloid leukemia_Homo sapiens_hsa052210.69569732
52Steroid biosynthesis_Homo sapiens_hsa001000.67784889
53Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.67658859
54N-Glycan biosynthesis_Homo sapiens_hsa005100.66228306
55Cyanoamino acid metabolism_Homo sapiens_hsa004600.65426503
56Prostate cancer_Homo sapiens_hsa052150.64208585
57Small cell lung cancer_Homo sapiens_hsa052220.63476179
58Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.62258042
59Herpes simplex infection_Homo sapiens_hsa051680.61701104
60Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.61661605
61MicroRNAs in cancer_Homo sapiens_hsa052060.59271956
62Alcoholism_Homo sapiens_hsa050340.59103341
63Apoptosis_Homo sapiens_hsa042100.57973225
64Endometrial cancer_Homo sapiens_hsa052130.55301878
65Hepatitis B_Homo sapiens_hsa051610.52670999
66Vitamin B6 metabolism_Homo sapiens_hsa007500.51845356
67Colorectal cancer_Homo sapiens_hsa052100.45563353
68Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.44641621
69Lysine degradation_Homo sapiens_hsa003100.44234274
70Inositol phosphate metabolism_Homo sapiens_hsa005620.42992794
71Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.42741156
72Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.37183740
73Thyroid hormone signaling pathway_Homo sapiens_hsa049190.36848924
74Drug metabolism - other enzymes_Homo sapiens_hsa009830.33389819
75Fatty acid elongation_Homo sapiens_hsa000620.33265632
76Glioma_Homo sapiens_hsa052140.31745638
77Transcriptional misregulation in cancer_Homo sapiens_hsa052020.31201008
78Arginine biosynthesis_Homo sapiens_hsa002200.30862241
79Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.30345564
80HIF-1 signaling pathway_Homo sapiens_hsa040660.29576715
81Regulation of autophagy_Homo sapiens_hsa041400.28961289
82Phenylalanine metabolism_Homo sapiens_hsa003600.28000583
83Insulin signaling pathway_Homo sapiens_hsa049100.27616027
84Fatty acid biosynthesis_Homo sapiens_hsa000610.27531039
85Primary immunodeficiency_Homo sapiens_hsa053400.27378520
86Huntingtons disease_Homo sapiens_hsa050160.26331898
87ErbB signaling pathway_Homo sapiens_hsa040120.25991300
88Longevity regulating pathway - mammal_Homo sapiens_hsa042110.25366097
89Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.25355222
90Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.25030594
91B cell receptor signaling pathway_Homo sapiens_hsa046620.24855290
92VEGF signaling pathway_Homo sapiens_hsa043700.23057488
93Dorso-ventral axis formation_Homo sapiens_hsa043200.22989836
94Phosphatidylinositol signaling system_Homo sapiens_hsa040700.22742063
95Shigellosis_Homo sapiens_hsa051310.22663832
96Vitamin digestion and absorption_Homo sapiens_hsa049770.22443843
97AMPK signaling pathway_Homo sapiens_hsa041520.22417265
98Influenza A_Homo sapiens_hsa051640.20377722
99Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.19726018
100Arginine and proline metabolism_Homo sapiens_hsa003300.19042630

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