TEX12

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is similar to a mouse gene that is expressed in the testis. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA methylation involved in gamete generation (GO:0043046)9.94173176
2* synaptonemal complex assembly (GO:0007130)9.62397045
3* synaptonemal complex organization (GO:0070193)8.81751698
4male meiosis (GO:0007140)8.29410267
5male meiosis I (GO:0007141)7.60815673
6meiotic nuclear division (GO:0007126)7.16218543
7regulation of meiosis I (GO:0060631)7.04553480
8meiotic chromosome segregation (GO:0045132)6.89495599
9meiosis I (GO:0007127)6.75737596
10* chromosome organization involved in meiosis (GO:0070192)6.57257271
11histone H3-K9 demethylation (GO:0033169)5.70658225
12resolution of meiotic recombination intermediates (GO:0000712)5.61190728
13* meiotic cell cycle process (GO:1903046)5.54218186
14reciprocal DNA recombination (GO:0035825)5.53515326
15reciprocal meiotic recombination (GO:0007131)5.53515326
16attachment of spindle microtubules to kinetochore (GO:0008608)5.31848965
17oogenesis (GO:0048477)5.21221150
18DNA replication checkpoint (GO:0000076)5.16474105
19mitotic metaphase plate congression (GO:0007080)5.03087601
20female gamete generation (GO:0007292)4.79843491
21DNA alkylation (GO:0006305)4.75726902
22DNA methylation (GO:0006306)4.75726902
23oocyte maturation (GO:0001556)4.75361908
24gene silencing by RNA (GO:0031047)4.67936064
25protein K6-linked ubiquitination (GO:0085020)4.63805839
26negative regulation of meiosis (GO:0045835)4.61090612
27sister chromatid cohesion (GO:0007062)4.51505494
28chromatin remodeling at centromere (GO:0031055)4.50671917
29regulation of histone H3-K9 methylation (GO:0051570)4.50295251
30regulation of double-strand break repair via homologous recombination (GO:0010569)4.45106375
31purine nucleobase biosynthetic process (GO:0009113)4.42591988
32histone H3-K36 demethylation (GO:0070544)4.40770874
33histone exchange (GO:0043486)4.40275356
34negative regulation of inclusion body assembly (GO:0090084)4.31643581
35meiotic cell cycle (GO:0051321)4.26369518
36metaphase plate congression (GO:0051310)4.24714624
37nuclear pore organization (GO:0006999)4.17831110
38CENP-A containing nucleosome assembly (GO:0034080)4.11989772
39kinetochore organization (GO:0051383)4.08289696
40kinetochore assembly (GO:0051382)4.06955803
41nuclear pore complex assembly (GO:0051292)4.02888708
42regulation of DNA endoreduplication (GO:0032875)3.88788659
43binding of sperm to zona pellucida (GO:0007339)3.84894351
44spermatid development (GO:0007286)3.83826920
45acrosome assembly (GO:0001675)3.81875104
46DNA replication-independent nucleosome assembly (GO:0006336)3.80077222
47DNA replication-independent nucleosome organization (GO:0034724)3.80077222
48embryonic body morphogenesis (GO:0010172)3.79975819
49axoneme assembly (GO:0035082)3.79191196
50regulation of meiosis (GO:0040020)3.78344827
51mitotic chromosome condensation (GO:0007076)3.77255090
52positive regulation of meiosis (GO:0045836)3.66902084
53epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.66628974
54maturation of 5.8S rRNA (GO:0000460)3.66608726
55establishment of chromosome localization (GO:0051303)3.66597514
56DNA methylation or demethylation (GO:0044728)3.66096943
57spindle checkpoint (GO:0031577)3.65294253
58positive regulation of translational initiation (GO:0045948)3.64122217
59regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.62978150
60nucleobase biosynthetic process (GO:0046112)3.62238664
61regulation of chromosome segregation (GO:0051983)3.61578383
62mitotic sister chromatid cohesion (GO:0007064)3.61034612
63positive regulation of chromosome segregation (GO:0051984)3.55753254
64mitotic spindle checkpoint (GO:0071174)3.54354014
65positive regulation of meiotic cell cycle (GO:0051446)3.52863008
66reproductive system development (GO:0061458)3.52725344
67sex differentiation (GO:0007548)3.51558340
687-methylguanosine mRNA capping (GO:0006370)3.44153682
69nuclear division (GO:0000280)3.39561996
70chromosome segregation (GO:0007059)3.39296709
71DNA damage induced protein phosphorylation (GO:0006975)3.38711557
72positive regulation of response to oxidative stress (GO:1902884)3.37513143
73positive regulation of cellular response to oxidative stress (GO:1900409)3.37513143
74monoubiquitinated protein deubiquitination (GO:0035520)3.36136603
75regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.35383198
767-methylguanosine RNA capping (GO:0009452)3.34893952
77RNA capping (GO:0036260)3.34893952
78negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.33528091
79mitotic spindle assembly checkpoint (GO:0007094)3.33466180
80regulation of hydrogen peroxide metabolic process (GO:0010310)3.33268326
81regulation of mitotic metaphase/anaphase transition (GO:0030071)3.32432424
82negative regulation of mitotic sister chromatid separation (GO:2000816)3.29626928
83negative regulation of mitotic sister chromatid segregation (GO:0033048)3.29626928
84negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.29626928
85negative regulation of sister chromatid segregation (GO:0033046)3.29626928
86negative regulation of chromosome segregation (GO:0051985)3.29175478
87regulation of cilium movement (GO:0003352)3.28387344
88positive regulation of mitotic sister chromatid separation (GO:1901970)3.28276940
89positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.28276940
90positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.28276940
91negative regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043518)3.26999575
92spindle assembly checkpoint (GO:0071173)3.26561459
93regulation of sister chromatid segregation (GO:0033045)3.26183452
94regulation of mitotic sister chromatid separation (GO:0010965)3.26183452
95regulation of mitotic sister chromatid segregation (GO:0033047)3.26183452
96regulation of DNA methylation (GO:0044030)3.22941508
97regulation of sister chromatid cohesion (GO:0007063)3.21679440
98fatty acid elongation (GO:0030497)3.21575963
99* DNA biosynthetic process (GO:0071897)3.20086783
100synapsis (GO:0007129)3.19947711
101negative regulation of nuclear division (GO:0051784)3.18649832
102acrosome reaction (GO:0007340)3.18581790
103* DNA synthesis involved in DNA repair (GO:0000731)3.18365154
104inner cell mass cell proliferation (GO:0001833)3.17281960
105organelle fission (GO:0048285)3.17199447
106gene silencing (GO:0016458)3.15808548
107DNA replication-dependent nucleosome organization (GO:0034723)3.15502535
108DNA replication-dependent nucleosome assembly (GO:0006335)3.15502535
109DNA modification (GO:0006304)3.14908653
110regulation of microtubule-based movement (GO:0060632)3.14454539
111regulation of regulatory T cell differentiation (GO:0045589)3.13428850
112histone H2A monoubiquitination (GO:0035518)3.10171234
113microtubule depolymerization (GO:0007019)3.08824492
114germ cell development (GO:0007281)3.08533479
115transcription elongation from RNA polymerase II promoter (GO:0006368)3.06214456
116genitalia morphogenesis (GO:0035112)3.06029468
117proteasome assembly (GO:0043248)3.05600839
118protein localization to chromosome (GO:0034502)3.05016277
119* chromosome organization (GO:0051276)3.04825842
120fertilization (GO:0009566)3.03218700
121regulation of meiotic cell cycle (GO:0051445)3.02182194
122protein localization to chromosome, centromeric region (GO:0071459)3.02129599
123pore complex assembly (GO:0046931)3.01677784
124centriole replication (GO:0007099)3.01114986
125protein localization to kinetochore (GO:0034501)3.00609700
126regulation of transcription from RNA polymerase I promoter (GO:0006356)3.00452000
127ribosome biogenesis (GO:0042254)3.00375607
128negative regulation of gene silencing (GO:0060969)2.99974198
129histone H2A acetylation (GO:0043968)2.99679955
130regulation of helicase activity (GO:0051095)2.97620587
131DNA double-strand break processing (GO:0000729)2.97174812
132transcription from RNA polymerase I promoter (GO:0006360)2.96403469
133protein ADP-ribosylation (GO:0006471)2.95465867
134histone demethylation (GO:0016577)2.90891298
135L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.88066663
136centriole assembly (GO:0098534)2.87147080
137epithelial cilium movement (GO:0003351)2.85314317
138sperm-egg recognition (GO:0035036)2.84536841
139gamete generation (GO:0007276)2.84374629
140body morphogenesis (GO:0010171)2.82321768
141DNA catabolic process, exonucleolytic (GO:0000738)2.78514077
142positive regulation of lamellipodium assembly (GO:0010592)2.78212064
143male gamete generation (GO:0048232)2.76008358
144spermatogenesis (GO:0007283)2.75750590
145positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc2.73641617
146histone lysine demethylation (GO:0070076)2.72297995
147sperm motility (GO:0030317)2.66656376
148histone H3-K9 methylation (GO:0051567)2.65309324
149cellular process involved in reproduction in multicellular organism (GO:0022412)2.64854185
150protein dealkylation (GO:0008214)2.64773601
151protein demethylation (GO:0006482)2.64773601
152negative regulation of appetite (GO:0032099)2.64541937
153negative regulation of response to food (GO:0032096)2.64541937
154negative regulation of signal transduction by p53 class mediator (GO:1901797)2.64214024
155negative regulation of meiotic cell cycle (GO:0051447)2.63468906
156negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class 2.52879362
157negative regulation of cyclin-dependent protein serine/threonine kinase activity (GO:0045736)2.51236116
158signal complex assembly (GO:0007172)2.49512898
159protein refolding (GO:0042026)2.45883334
160gonadal mesoderm development (GO:0007506)2.45280976
161L-methionine biosynthetic process (GO:0071265)2.45141549
162amino acid salvage (GO:0043102)2.45141549
163piRNA metabolic process (GO:0034587)12.8245763

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.07230739
2IGF1R_20145208_ChIP-Seq_DFB_Human5.26590859
3MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse5.16277167
4E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.74432479
5FOXM1_23109430_ChIP-Seq_U2OS_Human4.43999452
6FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.54528673
7AR_21909140_ChIP-Seq_LNCAP_Human3.52104698
8E2F4_17652178_ChIP-ChIP_JURKAT_Human3.47042652
9MYCN_21190229_ChIP-Seq_SHEP-21N_Human3.31207010
10KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.16682421
11TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.10998733
12FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.91243040
13ER_23166858_ChIP-Seq_MCF-7_Human2.88521842
14BP1_19119308_ChIP-ChIP_Hs578T_Human2.83706833
15CREB1_15753290_ChIP-ChIP_HEK293T_Human2.64213188
16GABP_17652178_ChIP-ChIP_JURKAT_Human2.63959554
17KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.51217062
18MYC_18555785_ChIP-Seq_MESCs_Mouse2.50011848
19VDR_22108803_ChIP-Seq_LS180_Human2.49285452
20KAP1_22055183_ChIP-Seq_ESCs_Mouse2.48879843
21JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.33924030
22SALL1_21062744_ChIP-ChIP_HESCs_Human2.28676960
23BMI1_23680149_ChIP-Seq_NPCS_Mouse2.24437179
24EST1_17652178_ChIP-ChIP_JURKAT_Human2.20499840
25* POU3F2_20337985_ChIP-ChIP_501MEL_Human2.17643512
26MYCN_18555785_ChIP-Seq_MESCs_Mouse2.15385681
27BCAT_22108803_ChIP-Seq_LS180_Human2.10878654
28TAF15_26573619_Chip-Seq_HEK293_Human2.08555794
29PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.00821207
30E2F1_21310950_ChIP-Seq_MCF-7_Human1.96120878
31CTBP1_25329375_ChIP-Seq_LNCAP_Human1.95369263
32ETS1_20019798_ChIP-Seq_JURKAT_Human1.93493424
33NELFA_20434984_ChIP-Seq_ESCs_Mouse1.91005004
34CTBP2_25329375_ChIP-Seq_LNCAP_Human1.89140264
35FLI1_27457419_Chip-Seq_LIVER_Mouse1.84853459
36MYC_19030024_ChIP-ChIP_MESCs_Mouse1.81757004
37CBX2_27304074_Chip-Seq_ESCs_Mouse1.80661190
38VDR_23849224_ChIP-Seq_CD4+_Human1.79959488
39ZNF274_21170338_ChIP-Seq_K562_Hela1.79680178
40CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.76514560
41MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.64777134
42FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.64315639
43MYC_18358816_ChIP-ChIP_MESCs_Mouse1.62979225
44EWS_26573619_Chip-Seq_HEK293_Human1.62486756
45AR_25329375_ChIP-Seq_VCAP_Human1.61797998
46PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.60399613
47CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.60212509
48MYC_19079543_ChIP-ChIP_MESCs_Mouse1.59543661
49DCP1A_22483619_ChIP-Seq_HELA_Human1.59234055
50POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.55072989
51GATA3_26560356_Chip-Seq_TH1_Human1.50548625
52HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.50410542
53CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.49421599
54GABP_19822575_ChIP-Seq_HepG2_Human1.43899972
55GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.43862716
56RBPJ_22232070_ChIP-Seq_NCS_Mouse1.42101207
57ERA_21632823_ChIP-Seq_H3396_Human1.41815008
58ESR1_20079471_ChIP-ChIP_T-47D_Human1.41554306
59TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.40667925
60FOXA1_21572438_ChIP-Seq_LNCaP_Human1.40436607
61PADI4_21655091_ChIP-ChIP_MCF-7_Human1.40182901
62PCGF2_27294783_Chip-Seq_ESCs_Mouse1.39969983
63PHF8_20622853_ChIP-Seq_HELA_Human1.39699774
64PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.39004250
65PRDM14_20953172_ChIP-Seq_ESCs_Human1.38045117
66E2F1_18555785_ChIP-Seq_MESCs_Mouse1.37793459
67RUNX2_22187159_ChIP-Seq_PCA_Human1.35315216
68KLF5_20875108_ChIP-Seq_MESCs_Mouse1.34527551
69UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.34461067
70GATA1_26923725_Chip-Seq_HPCs_Mouse1.31815284
71GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.31114012
72CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.30182489
73* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.29872090
74TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.29039945
75MYC_18940864_ChIP-ChIP_HL60_Human1.28420849
76NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.28233399
77SMAD4_21741376_ChIP-Seq_EPCs_Human1.27038942
78CBX2_22325352_ChIP-Seq_293T-Rex_Human1.26947447
79HTT_18923047_ChIP-ChIP_STHdh_Human1.26229349
80GATA6_21074721_ChIP-Seq_CACO-2_Human1.25825148
81TBL1_22424771_ChIP-Seq_293T_Human1.25515953
82RUNX1_26923725_Chip-Seq_HPCs_Mouse1.23344036
83GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.23308008
84TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human1.22718701
85NFE2_27457419_Chip-Seq_LIVER_Mouse1.20675226
86SMAD4_21799915_ChIP-Seq_A2780_Human1.20390216
87YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.20286280
88RNF2_27304074_Chip-Seq_NSC_Mouse1.20158242
89P300_19829295_ChIP-Seq_ESCs_Human1.19930430
90NANOG_18555785_ChIP-Seq_MESCs_Mouse1.18819782
91XRN2_22483619_ChIP-Seq_HELA_Human1.18786004
92GATA3_21867929_ChIP-Seq_TH1_Mouse1.17313856
93FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.16918317
94CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.16908592
95FOXP3_21729870_ChIP-Seq_TREG_Human1.15560949
96FOXA1_25329375_ChIP-Seq_VCAP_Human1.15271939
97FOXA1_27270436_Chip-Seq_PROSTATE_Human1.15271939
98KDM5A_27292631_Chip-Seq_BREAST_Human1.15224688
99LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.15134954
100NFYB_21822215_ChIP-Seq_K562_Human1.14624808
101MYC_19829295_ChIP-Seq_ESCs_Human1.12380683
102SRF_21415370_ChIP-Seq_HL-1_Mouse1.12211871
103PKCTHETA_26484144_Chip-Seq_BREAST_Human1.12051306
104HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.11428911
105* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.09427011
106ZFP57_27257070_Chip-Seq_ESCs_Mouse1.09137276
107TOP2B_26459242_ChIP-Seq_MCF-7_Human1.08952474
108E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.06715047
109SUZ12_27294783_Chip-Seq_NPCs_Mouse1.06364186
110AR_20517297_ChIP-Seq_VCAP_Human1.06224070
111MYB_26560356_Chip-Seq_TH2_Human1.05431764
112TCF4_22108803_ChIP-Seq_LS180_Human1.05418864
113IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.05257332
114CBP_20019798_ChIP-Seq_JUKART_Human1.05257332
115NOTCH1_21737748_ChIP-Seq_TLL_Human1.03921197
116* PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.03848441
117STAT3_23295773_ChIP-Seq_U87_Human1.02619355
118NANOG_18555785_Chip-Seq_ESCs_Mouse1.02371007
119EGR1_23403033_ChIP-Seq_LIVER_Mouse1.02062737
120NCOR_22424771_ChIP-Seq_293T_Human1.01026063
121KLF4_18555785_ChIP-Seq_MESCs_Mouse1.00223224
122GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.99634978
123TP53_22573176_ChIP-Seq_HFKS_Human0.97687042
124PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.97044102
125SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.96983260
126NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.96412791
127CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.96048395
128PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.95365548
129RUNX1_27457419_Chip-Seq_LIVER_Mouse0.94955262
130ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.93866470
131STAT1_17558387_ChIP-Seq_HELA_Human0.93760626
132SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.93533190
133YY1_21170310_ChIP-Seq_MESCs_Mouse0.92780103
134RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.92285084
135EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.92167155
136CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.91909087
137* SETDB1_19884257_ChIP-Seq_MESCs_Mouse0.90018123
138TP63_19390658_ChIP-ChIP_HaCaT_Human0.88192788
139RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.87710339
140HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.86126464
141STAT3_1855785_ChIP-Seq_MESCs_Mouse0.83035445
142LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.82623002
143FOXH1_21741376_ChIP-Seq_EPCs_Human0.81189533
144SMAD_19615063_ChIP-ChIP_OVARY_Human0.80119028
145ELK1_19687146_ChIP-ChIP_HELA_Human0.80051332
146SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.79982967
147HOXB4_20404135_ChIP-ChIP_EML_Mouse0.79841676
148EZH2_27294783_Chip-Seq_NPCs_Mouse0.79796232
149MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.78630275
150AUTS2_25519132_ChIP-Seq_293T-REX_Human0.78339251
151RBPJ_21746931_ChIP-Seq_IB4_Human0.76991916
152BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.75613614
153STAT3_18555785_Chip-Seq_ESCs_Mouse0.75063837
154* RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.74028904
155TTF2_22483619_ChIP-Seq_HELA_Human0.71894593
156HOXB7_26014856_ChIP-Seq_BT474_Human0.71641355
157FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.71481823
158FUS_26573619_Chip-Seq_HEK293_Human0.71233481
159CDX2_22108803_ChIP-Seq_LS180_Human0.71227044
160ETV1_20927104_ChIP-Seq_GIST48_Human0.70857175
161CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.69730887
162ESRRB_18555785_Chip-Seq_ESCs_Mouse0.69711715
163* TBX5_21415370_ChIP-Seq_HL-1_Mouse0.69598053
164HNFA_21074721_ChIP-Seq_CACO-2_Human0.68962346

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation8.81821316
2MP0003693_abnormal_embryo_hatching4.49009949
3MP0003718_maternal_effect4.13349409
4MP0008995_early_reproductive_senescence4.01320074
5* MP0002210_abnormal_sex_determination3.98570207
6MP0010094_abnormal_chromosome_stability3.77911745
7MP0008004_abnormal_stomach_pH3.66443016
8* MP0001929_abnormal_gametogenesis3.63674691
9MP0003111_abnormal_nucleus_morphology3.51897536
10MP0003786_premature_aging3.51893631
11MP0001145_abnormal_male_reproductive3.20226293
12* MP0000653_abnormal_sex_gland3.05911129
13MP0008057_abnormal_DNA_replication2.91254901
14MP0003077_abnormal_cell_cycle2.90739433
15MP0004957_abnormal_blastocyst_morpholog2.83410520
16* MP0003698_abnormal_male_reproductive2.68144093
17MP0003123_paternal_imprinting2.64479442
18MP0008007_abnormal_cellular_replicative2.44046773
19* MP0008058_abnormal_DNA_repair2.42646638
20MP0005451_abnormal_body_composition2.36634650
21* MP0001119_abnormal_female_reproductive2.08242712
22MP0006292_abnormal_olfactory_placode2.06231563
23MP0010234_abnormal_vibrissa_follicle1.92735582
24MP0008932_abnormal_embryonic_tissue1.89414220
25MP0003646_muscle_fatigue1.89251987
26MP0002139_abnormal_hepatobiliary_system1.86908242
27* MP0002161_abnormal_fertility/fecundity1.85244419
28MP0001984_abnormal_olfaction1.84849352
29MP0005360_urolithiasis1.80264800
30MP0000678_abnormal_parathyroid_gland1.79398002
31* MP0003699_abnormal_female_reproductive1.76892530
32MP0001188_hyperpigmentation1.70781293
33MP0005395_other_phenotype1.66573765
34MP0005410_abnormal_fertilization1.62158687
35MP0005310_abnormal_salivary_gland1.50703656
36MP0001730_embryonic_growth_arrest1.49201364
37MP0010678_abnormal_skin_adnexa1.43316482
38MP0000350_abnormal_cell_proliferation1.41910520
39MP0003315_abnormal_perineum_morphology1.39521520
40MP0008260_abnormal_autophagy1.28462866
41MP0001873_stomach_inflammation1.28190219
42MP0005647_abnormal_sex_gland1.26012700
43MP0000383_abnormal_hair_follicle1.22649757
44MP0008789_abnormal_olfactory_epithelium1.21152796
45MP0003121_genomic_imprinting1.20893155
46MP0003890_abnormal_embryonic-extraembry1.15898457
47MP0005365_abnormal_bile_salt1.14391817
48MP0002102_abnormal_ear_morphology1.13693636
49MP0005408_hypopigmentation1.08093524
50MP0009697_abnormal_copulation1.05603038
51MP0005671_abnormal_response_to1.04071253
52MP0005380_embryogenesis_phenotype1.00811977
53MP0001672_abnormal_embryogenesis/_devel1.00811977
54MP0003937_abnormal_limbs/digits/tail_de1.00158117
55MP0001501_abnormal_sleep_pattern1.00141503
56MP0010368_abnormal_lymphatic_system0.98833879
57MP0009840_abnormal_foam_cell0.97917878
58MP0005394_taste/olfaction_phenotype0.97874456
59MP0005499_abnormal_olfactory_system0.97874456
60MP0002160_abnormal_reproductive_system0.94571821
61MP0000579_abnormal_nail_morphology0.94559495
62MP0002166_altered_tumor_susceptibility0.93878888
63MP0002009_preneoplasia0.93439583
64MP0001529_abnormal_vocalization0.92982445
65MP0003787_abnormal_imprinting0.91383590
66MP0005330_cardiomyopathy0.89099608
67MP0005085_abnormal_gallbladder_physiolo0.87750871
68MP0003186_abnormal_redox_activity0.87419711
69MP0010307_abnormal_tumor_latency0.86704588
70MP0005389_reproductive_system_phenotype0.86326226
71MP0002132_abnormal_respiratory_system0.86071330
72MP0002085_abnormal_embryonic_tissue0.85543189
73MP0002653_abnormal_ependyma_morphology0.84375837
74MP0001697_abnormal_embryo_size0.83399874
75MP0002971_abnormal_brown_adipose0.83116145
76MP0003763_abnormal_thymus_physiology0.82350022
77MP0006035_abnormal_mitochondrial_morpho0.79125822
78MP0009672_abnormal_birth_weight0.77384343
79MP0003984_embryonic_growth_retardation0.76522411
80MP0009333_abnormal_splenocyte_physiolog0.75557008
81MP0000313_abnormal_cell_death0.73388253
82MP0004043_abnormal_pH_regulation0.73356448
83MP0002019_abnormal_tumor_incidence0.73295268
84MP0004142_abnormal_muscle_tone0.72788614
85MP0003936_abnormal_reproductive_system0.72113399
86MP0003191_abnormal_cellular_cholesterol0.70597338
87MP0002088_abnormal_embryonic_growth/wei0.70314554
88MP0002837_dystrophic_cardiac_calcinosis0.69431732
89MP0002080_prenatal_lethality0.63798715
90MP0008875_abnormal_xenobiotic_pharmacok0.63263034
91MP0004808_abnormal_hematopoietic_stem0.62582443
92MP0002249_abnormal_larynx_morphology0.62387158
93MP0006082_CNS_inflammation0.61607999
94MP0005076_abnormal_cell_differentiation0.61121659
95MP0003453_abnormal_keratinocyte_physiol0.59799036
96MP0004036_abnormal_muscle_relaxation0.59386363
97MP0005621_abnormal_cell_physiology0.59350537
98MP0002796_impaired_skin_barrier0.59253690
99MP0000749_muscle_degeneration0.58086785
100MP0003221_abnormal_cardiomyocyte_apopto0.55974860
101MP0001853_heart_inflammation0.55470045
102MP0002084_abnormal_developmental_patter0.55320493
103MP0000465_gastrointestinal_hemorrhage0.55282135
104MP0005332_abnormal_amino_acid0.55082359
105MP0003868_abnormal_feces_composition0.54992316
106MP0003632_abnormal_nervous_system0.54028926
107MP0002269_muscular_atrophy0.53808628
108MP0002396_abnormal_hematopoietic_system0.52729772
109MP0009703_decreased_birth_body0.52546379
110MP0001177_atelectasis0.52474184
111MP0005058_abnormal_lysosome_morphology0.52308307
112MP0002006_tumorigenesis0.52301941
113MP0001661_extended_life_span0.51642178
114MP0000566_synostosis0.51563303
115MP0005275_abnormal_skin_tensile0.49821290
116MP0005384_cellular_phenotype0.49758723
117MP0003879_abnormal_hair_cell0.49473206
118MP0004019_abnormal_vitamin_homeostasis0.49250886
119MP0000013_abnormal_adipose_tissue0.48001435
120MP0004197_abnormal_fetal_growth/weight/0.47328441
121MP0000703_abnormal_thymus_morphology0.46090958
122MP0001764_abnormal_homeostasis0.45585208
123MP0003938_abnormal_ear_development0.45075687
124MP0004085_abnormal_heartbeat0.44151532
125MP0001191_abnormal_skin_condition0.44151048
126MP0010030_abnormal_orbit_morphology0.43540600
127MP0002086_abnormal_extraembryonic_tissu0.42658140
128MP0000427_abnormal_hair_cycle0.41631708
129MP0001293_anophthalmia0.41562891
130MP0001485_abnormal_pinna_reflex0.41417452
131MP0004145_abnormal_muscle_electrophysio0.41313634
132MP0000609_abnormal_liver_physiology0.40061116
133MP0003755_abnormal_palate_morphology0.38518711
134MP0002092_abnormal_eye_morphology0.38485734
135MP0002693_abnormal_pancreas_physiology0.38436072
136MP0002638_abnormal_pupillary_reflex0.38099977
137MP0000639_abnormal_adrenal_gland0.38003856
138MP0002277_abnormal_respiratory_mucosa0.37894711
139MP0006036_abnormal_mitochondrial_physio0.37045589
140MP0010329_abnormal_lipoprotein_level0.36955093
141MP0003943_abnormal_hepatobiliary_system0.36926628
142MP0000778_abnormal_nervous_system0.36616119
143MP0003137_abnormal_impulse_conducting0.36480111
144MP0000627_abnormal_mammary_gland0.35887576
145MP0001664_abnormal_digestion0.35835898
146MP0003941_abnormal_skin_development0.35606690
147MP0001919_abnormal_reproductive_system0.34571772
148MP0000647_abnormal_sebaceous_gland0.34253240
149MP0000432_abnormal_head_morphology0.33823722
150MP0003638_abnormal_response/metabolism_0.33767922
151MP0001915_intracranial_hemorrhage0.33570272
152MP0001542_abnormal_bone_strength0.33290152
153MP0004782_abnormal_surfactant_physiolog0.33100349
154MP0000631_abnormal_neuroendocrine_gland0.32807519
155MP0003806_abnormal_nucleotide_metabolis0.32475432
156MP0003115_abnormal_respiratory_system0.32084618

Predicted human phenotypes

RankGene SetZ-score
1Azoospermia (HP:0000027)8.20773802
2Abnormal spermatogenesis (HP:0008669)7.52622853
3Amyotrophic lateral sclerosis (HP:0007354)5.00020473
4Chromsome breakage (HP:0040012)4.85918029
5Volvulus (HP:0002580)4.77910954
6Chromosomal breakage induced by crosslinking agents (HP:0003221)4.69110823
7Oligodactyly (hands) (HP:0001180)4.67042220
8Rimmed vacuoles (HP:0003805)4.66264317
9Abnormality of the labia minora (HP:0012880)4.55998416
10Impulsivity (HP:0100710)4.54375411
11Lip pit (HP:0100267)4.51750174
12Carpal bone hypoplasia (HP:0001498)4.41695051
13Breast hypoplasia (HP:0003187)4.29846221
14Birth length less than 3rd percentile (HP:0003561)4.26800414
15Spontaneous abortion (HP:0005268)4.08279746
16Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)4.07926232
17Degeneration of the lateral corticospinal tracts (HP:0002314)4.07926232
18Facial hemangioma (HP:0000329)3.90319527
19Aplastic anemia (HP:0001915)3.89483581
20Abnormality of the corticospinal tract (HP:0002492)3.80597828
21Patellar aplasia (HP:0006443)3.80097744
22Atrophy/Degeneration involving motor neurons (HP:0007373)3.78797803
23Capillary hemangiomas (HP:0005306)3.73712785
24Oligodactyly (HP:0012165)3.71971261
25Aplasia/Hypoplasia involving the carpal bones (HP:0006502)3.68631510
26Aplasia/Hypoplasia involving the musculature (HP:0001460)3.68453041
27Tubulointerstitial nephritis (HP:0001970)3.62333507
28Supernumerary spleens (HP:0009799)3.53631242
29Horizontal nystagmus (HP:0000666)3.52675016
30Aplasia/Hypoplasia of the patella (HP:0006498)3.48234510
31Male infertility (HP:0003251)3.45770637
32Absent radius (HP:0003974)3.34944284
33Nephrogenic diabetes insipidus (HP:0009806)3.32750065
34Absent forearm bone (HP:0003953)3.29585551
35Aplasia involving forearm bones (HP:0009822)3.29585551
36Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.17320116
37Gonadotropin excess (HP:0000837)3.10929769
38Abnormal protein N-linked glycosylation (HP:0012347)3.07253225
39Abnormal protein glycosylation (HP:0012346)3.07253225
40Abnormal glycosylation (HP:0012345)3.07253225
41Abnormal isoelectric focusing of serum transferrin (HP:0003160)3.07253225
42Hyperglycinemia (HP:0002154)3.06149559
43Abnormality of chromosome stability (HP:0003220)3.04000564
44Pancreatic fibrosis (HP:0100732)2.91126907
45Resting tremor (HP:0002322)2.90475681
46Congenital primary aphakia (HP:0007707)2.87357569
47Papillary thyroid carcinoma (HP:0002895)2.85208610
48Gait imbalance (HP:0002141)2.78750918
49Posterior subcapsular cataract (HP:0007787)2.73275210
50Horseshoe kidney (HP:0000085)2.71154547
51Medial flaring of the eyebrow (HP:0010747)2.68623563
52Meckel diverticulum (HP:0002245)2.68390757
53Hyperglycinuria (HP:0003108)2.61246044
54Hypoplasia of the uterus (HP:0000013)2.60505518
55Secondary amenorrhea (HP:0000869)2.57009573
56Abnormality of the preputium (HP:0100587)2.54877322
57Hand muscle atrophy (HP:0009130)2.54869659
58Urinary urgency (HP:0000012)2.54747575
59Microretrognathia (HP:0000308)2.52388266
60Abnormality of lateral ventricle (HP:0030047)2.52142831
61Upper motor neuron abnormality (HP:0002127)2.50914463
6211 pairs of ribs (HP:0000878)2.49964436
63Shawl scrotum (HP:0000049)2.49122701
64Prolonged neonatal jaundice (HP:0006579)2.47241807
65Impaired vibration sensation in the lower limbs (HP:0002166)2.46890780
66Abnormality of the lower motor neuron (HP:0002366)2.46689297
67Aplasia/Hypoplasia of the ulna (HP:0006495)2.40543845
68Abnormality of the ileum (HP:0001549)2.39375592
69Limb dystonia (HP:0002451)2.35712251
70Abnormality of chromosome segregation (HP:0002916)2.35536469
71Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.34049146
72Aplasia/Hypoplasia of the uvula (HP:0010293)2.30953453
73Adrenal hypoplasia (HP:0000835)2.30216060
74Ectopic kidney (HP:0000086)2.25927033
75Short thumb (HP:0009778)2.25555698
76Wrist flexion contracture (HP:0001239)2.24048668
77Tetraplegia (HP:0002445)2.23328011
78Aplasia/Hypoplasia of the earlobes (HP:0009906)2.22627732
79Breast aplasia (HP:0100783)2.21913351
80Amniotic constriction ring (HP:0009775)2.19717694
81Abnormality of placental membranes (HP:0011409)2.19717694
82Pseudobulbar signs (HP:0002200)2.17792380
83Poor coordination (HP:0002370)2.16571671
84Infertility (HP:0000789)2.16449306
85Aplasia/Hypoplasia of the breasts (HP:0010311)2.14952153
86Premature ovarian failure (HP:0008209)2.14035650
87Genital tract atresia (HP:0001827)2.12759073
88Degeneration of anterior horn cells (HP:0002398)2.12548195
89Abnormality of the anterior horn cell (HP:0006802)2.12548195
90Absent speech (HP:0001344)2.11703728
91Ankle contracture (HP:0006466)2.11363786
92Sandal gap (HP:0001852)2.11227793
93Fair hair (HP:0002286)2.10881072
94Stenosis of the external auditory canal (HP:0000402)2.10471537
95Cleft eyelid (HP:0000625)2.10087500
96Type I transferrin isoform profile (HP:0003642)2.09898033
97Neoplasm of the oral cavity (HP:0100649)2.09556698
98Abnormal lung lobation (HP:0002101)2.08208770
99Stillbirth (HP:0003826)2.07175523
100Vaginal atresia (HP:0000148)2.07122723
101Hypoplastic labia majora (HP:0000059)2.06880424
102Unsteady gait (HP:0002317)2.06398455
103Short tibia (HP:0005736)2.05982668
104Fibular aplasia (HP:0002990)2.05197108
105Hypobetalipoproteinemia (HP:0003563)2.04910098
106Broad alveolar ridges (HP:0000187)2.03838119
107Rhinitis (HP:0012384)2.03382551
108Heterotopia (HP:0002282)2.00921894
109Abnormality of serine family amino acid metabolism (HP:0010894)2.00183036
110Abnormality of glycine metabolism (HP:0010895)2.00183036
111Duodenal stenosis (HP:0100867)1.99374615
112Small intestinal stenosis (HP:0012848)1.99374615
113Median cleft lip (HP:0000161)1.98046989
114Pancreatic cysts (HP:0001737)1.97978431
115Aplasia/Hypoplasia of the sternum (HP:0006714)1.97769322
116Hypoplastic iliac wings (HP:0002866)1.97739755
117Abnormality of midbrain morphology (HP:0002418)1.94830748
118Molar tooth sign on MRI (HP:0002419)1.94830748
119Aplasia/Hypoplasia of the tibia (HP:0005772)1.94288547
120Abnormality of the clitoris (HP:0000056)1.94141389
121Spastic gait (HP:0002064)1.93313335
122Rough bone trabeculation (HP:0100670)1.92005417
123Increased nuchal translucency (HP:0010880)1.90929790
124Prominent nose (HP:0000448)1.90858588
125Multicystic kidney dysplasia (HP:0000003)1.90823354
126Abnormality of the labia majora (HP:0012881)1.90464079
127Exocrine pancreatic insufficiency (HP:0001738)1.88961213
128Truncal obesity (HP:0001956)1.88683651
129Entropion (HP:0000621)1.88323439
130Aplasia/hypoplasia of the uterus (HP:0008684)1.88080975
131External ophthalmoplegia (HP:0000544)1.87818361
132Cystic hygroma (HP:0000476)1.86848813
133Muscle fiber splitting (HP:0003555)1.86723618
134Hypoplasia of the capital femoral epiphysis (HP:0003090)1.84597488
135Small epiphyses (HP:0010585)1.82909765
136Type II lissencephaly (HP:0007260)1.82482433
137Cerebral hypomyelination (HP:0006808)1.81959477
138Osteomalacia (HP:0002749)1.81038184
139Prominent supraorbital ridges (HP:0000336)1.80395105
140Large hands (HP:0001176)1.80057869
141Type 2 muscle fiber atrophy (HP:0003554)1.79392378
142Hyperpituitarism (HP:0010514)1.79167596
143Intrahepatic cholestasis (HP:0001406)1.79041422
144Irregular epiphyses (HP:0010582)1.78773078
145Abnormality of cochlea (HP:0000375)1.78420068
146Flat capital femoral epiphysis (HP:0003370)1.78104985
147Chronic bronchitis (HP:0004469)1.77860636
148Aplasia/Hypoplasia of the fibula (HP:0006492)1.76070505
149Ventricular fibrillation (HP:0001663)1.75221526
150Synostosis of carpal bones (HP:0005048)1.75035963
151Abnormality of the proximal phalanges of the hand (HP:0009834)1.74814568
152Gout (HP:0001997)1.74507046
153Ureteral duplication (HP:0000073)1.73795699
154Cortical dysplasia (HP:0002539)1.73627133
155Upper limb amyotrophy (HP:0009129)1.73282391
156Distal upper limb amyotrophy (HP:0007149)1.73282391
157Microglossia (HP:0000171)1.73258381
158Oral leukoplakia (HP:0002745)1.73024669
159Abnormal respiratory motile cilium physiology (HP:0012261)1.72815811
160Clubbing of toes (HP:0100760)1.72217521
161Abnormality of DNA repair (HP:0003254)1.72073814
162Sloping forehead (HP:0000340)1.71580491
163Abnormal respiratory epithelium morphology (HP:0012253)1.70817381
164Abnormal respiratory motile cilium morphology (HP:0005938)1.70817381
165Shoulder girdle muscle weakness (HP:0003547)1.70257726
166Sensorimotor neuropathy (HP:0007141)1.69796307
167Pili torti (HP:0003777)1.69637356
168X-linked dominant inheritance (HP:0001423)1.69160221
169Abnormality of the labia (HP:0000058)1.68724709
170Abnormality of the shoulder girdle musculature (HP:0001435)1.68344671
171Abnormality of serum amino acid levels (HP:0003112)1.67988351
172Non-midline cleft lip (HP:0100335)1.67688032
173Follicular hyperkeratosis (HP:0007502)1.67247580
174Selective tooth agenesis (HP:0001592)1.67025354
175Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.65414536
176Decreased activity of mitochondrial respiratory chain (HP:0008972)1.65414536
177Bulbar palsy (HP:0001283)1.64725100
178Dynein arm defect of respiratory motile cilia (HP:0012255)1.64361581
179Absent/shortened dynein arms (HP:0200106)1.64361581

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PNCK7.14727266
2BRSK24.86893126
3ACVR1B4.86250598
4CDK194.80474740
5CDC73.78625005
6WEE13.53780490
7PLK43.52928182
8TXK3.14742027
9BRSK12.83614897
10STK38L2.63635387
11TTK2.62400055
12NEK22.60516327
13EIF2AK12.40027515
14MET2.37547076
15MAP3K62.34924214
16IRAK32.32759654
17PLK12.30988926
18SRPK12.09857926
19CHEK22.03988289
20BUB12.01186692
21FGR1.96331950
22CDK121.94482356
23PLK31.93295948
24PINK11.86388835
25LATS21.84957277
26FRK1.73408275
27ERBB41.72770066
28LATS11.71996738
29PTK2B1.70237143
30DYRK31.68150751
31STK31.64127908
32MAP3K21.59227657
33OXSR11.59130797
34MKNK21.57604666
35CCNB11.57537556
36FES1.57256536
37MARK31.55765920
38CAMK1G1.55259667
39EIF2AK31.49025758
40PBK1.48832208
41CDK81.45997154
42MAP3K51.43487738
43MUSK1.41471648
44MELK1.31262314
45CHEK11.29257026
46CSF1R1.27456033
47ERBB31.22452173
48DYRK21.20281505
49BMX1.20154217
50AURKB1.20067299
51OBSCN1.18767293
52STK241.18454264
53BRAF1.16165610
54PDGFRB1.14248549
55NEK91.14182834
56TAOK31.13429036
57CDK71.08782591
58ATR1.06657480
59PDK41.05837935
60PDK31.05837935
61CDK31.00465489
62NEK10.98786505
63BCR0.96324226
64CASK0.95822025
65ABL20.95332127
66MST40.89477651
67ATM0.87682370
68KDR0.85237867
69MAP3K130.81058267
70TYRO30.80175811
71MAP3K100.79556760
72RPS6KA40.77774645
73AURKA0.75873685
74MKNK10.75097614
75CDK90.74723221
76EGFR0.73601897
77MAP2K70.72832624
78TLK10.72012027
79RET0.71467324
80RAF10.71220093
81CDK20.70577141
82NEK60.70432709
83VRK10.68163365
84NLK0.67088056
85CDK10.66800816
86RPS6KA50.66633106
87BMPR20.65192215
88CDK40.64415535
89RPS6KB10.60771669
90STK160.60697657
91MST1R0.60426716
92MAPK110.60029443
93ROCK10.59240392
94MAP3K80.56803258
95PRKD30.55255693
96MAP3K40.54939964
97BMPR1B0.54905384
98SGK10.54853005
99EIF2AK20.51310438
100PRKAA10.51062085
101SGK2230.49965790
102SGK4940.49965790
103CSNK1G10.49498245
104PLK20.49338810
105CSK0.48228596
106AKT30.45819721
107CSNK2A10.45725620
108PDK20.43865473
109FER0.43066153
110IRAK20.42708717
111CDK140.42624489
112DYRK1A0.42546348
113EPHA20.42375413
114MOS0.42058239
115GRK10.41827299
116CDK60.41294753
117PDK10.41235851
118ITK0.40238994
119JAK20.39657532
120LCK0.39511705
121TAOK10.38824782
122IGF1R0.38596930
123CSNK1G20.38235883
124STK40.37670146
125PRKCQ0.37470751
126CDK11A0.35195570
127MAP3K90.35129277
128FGFR20.31604502
129TNK20.31346446
130MYLK0.31267682
131WNK30.30956433
132ZAK0.30797961
133CAMK10.30433858
134CSNK1G30.29797847
135PRKCI0.28509565
136MAPK130.28223882
137SGK20.28152330
138KSR10.28131639
139GRK70.28036459
140STK110.27781699
141CDK50.27539101
142DMPK0.26029362
143TYK20.23987870
144WNK10.23982441
145IRAK40.23617131
146JAK30.23169023
147GSK3B0.22937276
148BRD40.22610912
149KSR20.22502255
150CSNK2A20.21800644
151IRAK10.21231209
152NUAK10.19913246
153MAPK80.19681372
154STK380.18821726
155ARAF0.15625539
156ABL10.14963116

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.87942143
2Vitamin B6 metabolism_Homo sapiens_hsa007504.53524374
3RNA polymerase_Homo sapiens_hsa030204.53307272
4Basal transcription factors_Homo sapiens_hsa030223.96213260
5Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.78257684
6Homologous recombination_Homo sapiens_hsa034403.19194668
7Cell cycle_Homo sapiens_hsa041103.15816615
8DNA replication_Homo sapiens_hsa030302.97485569
9RNA transport_Homo sapiens_hsa030132.95270653
10Pathogenic Escherichia coli infection_Homo sapiens_hsa051302.92747805
11Fanconi anemia pathway_Homo sapiens_hsa034602.48608481
12Mismatch repair_Homo sapiens_hsa034302.37681550
13Proteasome_Homo sapiens_hsa030502.21966711
14Nucleotide excision repair_Homo sapiens_hsa034202.19231439
15Pyrimidine metabolism_Homo sapiens_hsa002402.18782303
16Sulfur relay system_Homo sapiens_hsa041222.01978081
17RNA degradation_Homo sapiens_hsa030182.00631769
18p53 signaling pathway_Homo sapiens_hsa041151.89264155
19Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.89196081
20Steroid biosynthesis_Homo sapiens_hsa001001.81246431
21SNARE interactions in vesicular transport_Homo sapiens_hsa041301.80494130
22mRNA surveillance pathway_Homo sapiens_hsa030151.69790597
23Spliceosome_Homo sapiens_hsa030401.69700408
24Purine metabolism_Homo sapiens_hsa002301.57984751
25Oocyte meiosis_Homo sapiens_hsa041141.56433643
26Base excision repair_Homo sapiens_hsa034101.53023837
27Pentose phosphate pathway_Homo sapiens_hsa000301.52438588
28Primary bile acid biosynthesis_Homo sapiens_hsa001201.44117643
29One carbon pool by folate_Homo sapiens_hsa006701.30117601
30Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.19644688
31Selenocompound metabolism_Homo sapiens_hsa004501.19309490
32Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.13335220
33T cell receptor signaling pathway_Homo sapiens_hsa046601.12863432
34Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.09604363
35Non-homologous end-joining_Homo sapiens_hsa034501.08883947
36Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.07732938
37alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.05911879
38Ether lipid metabolism_Homo sapiens_hsa005651.05364182
39Linoleic acid metabolism_Homo sapiens_hsa005911.04626262
40Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.04511335
41Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.01553322
42Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.98502140
43Circadian rhythm_Homo sapiens_hsa047100.97926829
44Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.96503111
45Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.96337272
46Cysteine and methionine metabolism_Homo sapiens_hsa002700.96043064
47Fatty acid biosynthesis_Homo sapiens_hsa000610.95456590
48Glycerophospholipid metabolism_Homo sapiens_hsa005640.95324810
49Epstein-Barr virus infection_Homo sapiens_hsa051690.95056037
50Protein export_Homo sapiens_hsa030600.94110049
51Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.93537655
52Herpes simplex infection_Homo sapiens_hsa051680.93503995
53Biosynthesis of amino acids_Homo sapiens_hsa012300.93104556
54Dorso-ventral axis formation_Homo sapiens_hsa043200.91007005
55Folate biosynthesis_Homo sapiens_hsa007900.87701430
56Primary immunodeficiency_Homo sapiens_hsa053400.83997547
57Peroxisome_Homo sapiens_hsa041460.81323220
58Regulation of autophagy_Homo sapiens_hsa041400.80279671
59Drug metabolism - other enzymes_Homo sapiens_hsa009830.75853203
60Shigellosis_Homo sapiens_hsa051310.75785354
61ABC transporters_Homo sapiens_hsa020100.74700979
62Viral myocarditis_Homo sapiens_hsa054160.74388018
63Cyanoamino acid metabolism_Homo sapiens_hsa004600.73385581
64Hedgehog signaling pathway_Homo sapiens_hsa043400.71958082
65MAPK signaling pathway_Homo sapiens_hsa040100.70918509
66Glucagon signaling pathway_Homo sapiens_hsa049220.69722140
67Vitamin digestion and absorption_Homo sapiens_hsa049770.68942954
68Fatty acid metabolism_Homo sapiens_hsa012120.66223770
69Glycerolipid metabolism_Homo sapiens_hsa005610.65197952
70Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.65040696
71Complement and coagulation cascades_Homo sapiens_hsa046100.64302402
72Olfactory transduction_Homo sapiens_hsa047400.62614947
73beta-Alanine metabolism_Homo sapiens_hsa004100.61878576
74Phototransduction_Homo sapiens_hsa047440.60421330
75Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.59672550
76Gap junction_Homo sapiens_hsa045400.57437154
77Autoimmune thyroid disease_Homo sapiens_hsa053200.56135321
78Arginine biosynthesis_Homo sapiens_hsa002200.55306128
79Steroid hormone biosynthesis_Homo sapiens_hsa001400.54617410
80Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.52789856
81TGF-beta signaling pathway_Homo sapiens_hsa043500.52694407
82Staphylococcus aureus infection_Homo sapiens_hsa051500.51536217
83Other glycan degradation_Homo sapiens_hsa005110.50738976
84Glutathione metabolism_Homo sapiens_hsa004800.50327205
85Transcriptional misregulation in cancer_Homo sapiens_hsa052020.49837135
86Parkinsons disease_Homo sapiens_hsa050120.49040421
87Amphetamine addiction_Homo sapiens_hsa050310.48525192
88Regulation of actin cytoskeleton_Homo sapiens_hsa048100.48512062
89Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.47082682
90Caffeine metabolism_Homo sapiens_hsa002320.46589087
91Arachidonic acid metabolism_Homo sapiens_hsa005900.46501696
92Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.45479691
93Metabolic pathways_Homo sapiens_hsa011000.43018301
94Ovarian steroidogenesis_Homo sapiens_hsa049130.42926675
95Fatty acid degradation_Homo sapiens_hsa000710.42610531
96Antigen processing and presentation_Homo sapiens_hsa046120.42332505
97Arginine and proline metabolism_Homo sapiens_hsa003300.41997233
98Phenylalanine metabolism_Homo sapiens_hsa003600.41952681
99Influenza A_Homo sapiens_hsa051640.41433198
100Legionellosis_Homo sapiens_hsa051340.40914879
101Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.40569394
1022-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.38188000
103VEGF signaling pathway_Homo sapiens_hsa043700.38157027
104Alcoholism_Homo sapiens_hsa050340.37701545
105Choline metabolism in cancer_Homo sapiens_hsa052310.37295126
106Phagosome_Homo sapiens_hsa041450.36657558
107Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.36406955
108FoxO signaling pathway_Homo sapiens_hsa040680.35259321
109mTOR signaling pathway_Homo sapiens_hsa041500.34552784
110Systemic lupus erythematosus_Homo sapiens_hsa053220.33621602
111Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.32633301
112Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.32347548
113PPAR signaling pathway_Homo sapiens_hsa033200.32329229
114Tyrosine metabolism_Homo sapiens_hsa003500.32194567
115Calcium signaling pathway_Homo sapiens_hsa040200.32163590
116Chemical carcinogenesis_Homo sapiens_hsa052040.31930479
117Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.31170342
118Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.30251935
119Synaptic vesicle cycle_Homo sapiens_hsa047210.30212585
120Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.29817538
121Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.29804661
122N-Glycan biosynthesis_Homo sapiens_hsa005100.29514873
123cGMP-PKG signaling pathway_Homo sapiens_hsa040220.29323955
124Carbon metabolism_Homo sapiens_hsa012000.29314555
125Fructose and mannose metabolism_Homo sapiens_hsa000510.29139780
126NOD-like receptor signaling pathway_Homo sapiens_hsa046210.28090881
127Butanoate metabolism_Homo sapiens_hsa006500.28039001
128Histidine metabolism_Homo sapiens_hsa003400.28023166
129Sphingolipid metabolism_Homo sapiens_hsa006000.27299588
130Salmonella infection_Homo sapiens_hsa051320.26855761
131Nitrogen metabolism_Homo sapiens_hsa009100.26653362
132Apoptosis_Homo sapiens_hsa042100.26589530
133Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.26328291
134Propanoate metabolism_Homo sapiens_hsa006400.26136784
135HTLV-I infection_Homo sapiens_hsa051660.26038076
136Retinol metabolism_Homo sapiens_hsa008300.25924099
137MicroRNAs in cancer_Homo sapiens_hsa052060.25629287
138Fatty acid elongation_Homo sapiens_hsa000620.25267929
139Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.24967764
140Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.24835228
141Pentose and glucuronate interconversions_Homo sapiens_hsa000400.22343286
142Huntingtons disease_Homo sapiens_hsa050160.21399262
143Vascular smooth muscle contraction_Homo sapiens_hsa042700.19436308
144Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.18996840
145Fat digestion and absorption_Homo sapiens_hsa049750.17411606
146Mineral absorption_Homo sapiens_hsa049780.17271919

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