TET2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a methylcytosine dioxygenase that catalyzes the conversion of methylcytosine to 5-hydroxymethylcytosine. The encoded protein is involved in myelopoiesis, and defects in this gene have been associated with several myeloproliferative disorders. Two variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of B cell receptor signaling pathway (GO:0050855)5.32982246
2negative regulation of cell killing (GO:0031342)4.60530847
3negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.60530847
4cellular extravasation (GO:0045123)4.51764888
5modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.47711039
6modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.47711039
7positive regulation by organism of defense response of other organism involved in symbiotic interact4.47711039
8modulation by symbiont of host immune response (GO:0052553)4.47711039
9positive regulation by symbiont of host defense response (GO:0052509)4.47711039
10modulation by symbiont of host defense response (GO:0052031)4.47711039
11regulation of gamma-delta T cell activation (GO:0046643)4.22123423
12positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.87297466
13positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.85641581
14regulation of gamma-delta T cell differentiation (GO:0045586)3.80868022
15response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.80493263
16response to host immune response (GO:0052572)3.80493263
17positive regulation of cellular amide metabolic process (GO:0034250)3.79337337
18detection of external biotic stimulus (GO:0098581)3.73077543
19positive regulation of mast cell activation (GO:0033005)3.63532747
20B cell receptor signaling pathway (GO:0050853)3.59766207
21antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.59043087
22positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.57947990
23response to peptidoglycan (GO:0032494)3.52760030
24myeloid leukocyte mediated immunity (GO:0002444)3.49927982
25regulation of dendritic cell antigen processing and presentation (GO:0002604)3.47010531
26negative regulation of T cell mediated immunity (GO:0002710)3.42919407
27I-kappaB phosphorylation (GO:0007252)3.42807616
28negative regulation of translation, ncRNA-mediated (GO:0040033)3.42028208
29regulation of translation, ncRNA-mediated (GO:0045974)3.42028208
30negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.42028208
31response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.41668549
32response to host (GO:0075136)3.41668549
33response to host defenses (GO:0052200)3.41668549
34regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.39760642
35detection of biotic stimulus (GO:0009595)3.38631471
36regulation of mast cell activation (GO:0033003)3.38615246
37positive regulation of interferon-alpha production (GO:0032727)3.38221107
38hepatocyte apoptotic process (GO:0097284)3.36007136
39negative regulation of lymphocyte mediated immunity (GO:0002707)3.35509493
40regulation of interferon-alpha production (GO:0032647)3.31292687
41regulation of memory T cell differentiation (GO:0043380)3.24447087
42phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.24343795
43microglial cell activation (GO:0001774)3.23770018
44macrophage activation involved in immune response (GO:0002281)3.19407499
45histone H3-K36 demethylation (GO:0070544)3.18886286
46neutrophil activation involved in immune response (GO:0002283)3.15356046
47detection of bacterium (GO:0016045)3.13703608
48positive regulation of gamma-delta T cell activation (GO:0046645)3.13491469
49* histone H3-K4 trimethylation (GO:0080182)3.12844751
50positive regulation of interleukin-1 beta secretion (GO:0050718)3.12562816
51NIK/NF-kappaB signaling (GO:0038061)3.12283388
52interferon-gamma production (GO:0032609)3.11815302
53positive regulation of granulocyte differentiation (GO:0030854)3.10030141
54negative thymic T cell selection (GO:0045060)3.09251788
55regulation of MHC class I biosynthetic process (GO:0045343)3.07058849
56neutrophil activation (GO:0042119)3.06795742
57positive regulation of B cell differentiation (GO:0045579)3.06708858
58negative regulation of B cell proliferation (GO:0030889)3.05091690
59regulation of mast cell activation involved in immune response (GO:0033006)3.04460028
60negative T cell selection (GO:0043383)3.04317168
61regulation of protein polyubiquitination (GO:1902914)3.04259888
62regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.03488986
63positive regulation of mast cell activation involved in immune response (GO:0033008)3.03185082
64positive regulation of mast cell degranulation (GO:0043306)3.03185082
65activated T cell proliferation (GO:0050798)3.00683610
66response to muramyl dipeptide (GO:0032495)3.00396263
67cellular response to ethanol (GO:0071361)2.99324470
68regulation of interferon-beta biosynthetic process (GO:0045357)2.98250160
69negative regulation of type 2 immune response (GO:0002829)2.98057944
70positive regulation of antigen processing and presentation (GO:0002579)2.96110216
71regulation of mast cell degranulation (GO:0043304)2.95211164
72regulation of B cell differentiation (GO:0045577)2.95202494
73positive regulation of heat generation (GO:0031652)2.92224225
74negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.92166192
75negative regulation of T-helper cell differentiation (GO:0045623)2.92166192
76negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.91963402
77defense response to protozoan (GO:0042832)2.91074573
78negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.90684466
79granulocyte activation (GO:0036230)2.90523509
80positive regulation of interleukin-12 production (GO:0032735)2.89397060
81regulation of interleukin-6 biosynthetic process (GO:0045408)2.89349947
82positive regulation of interferon-beta production (GO:0032728)2.88451561
83positive regulation of interleukin-1 secretion (GO:0050716)2.88010657
84response to interleukin-15 (GO:0070672)2.87532062
85regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.86290452
86superoxide anion generation (GO:0042554)2.85826768
87cytokine secretion (GO:0050663)2.84774230
88leukocyte aggregation (GO:0070486)2.82370441
89positive T cell selection (GO:0043368)2.80544699
90regulation of MHC class II biosynthetic process (GO:0045346)2.80043140
91* histone H3-K4 methylation (GO:0051568)2.79843381
92regulation of interleukin-1 beta secretion (GO:0050706)2.79286062
93antigen processing and presentation of endogenous antigen (GO:0019883)2.77495935
94negative regulation of adaptive immune response (GO:0002820)2.77294173
95T cell migration (GO:0072678)2.76993136
96respiratory burst (GO:0045730)2.76918801
97positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.75543223
98regulation of RIG-I signaling pathway (GO:0039535)2.75001344
99production of molecular mediator involved in inflammatory response (GO:0002532)2.74537671
100negative regulation of leukocyte mediated immunity (GO:0002704)2.74451649
101cellular response to interleukin-15 (GO:0071350)2.73817674
102cytoplasmic mRNA processing body assembly (GO:0033962)2.72483229
103regulation of interleukin-8 biosynthetic process (GO:0045414)2.71762955
104regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.71218185
105monoubiquitinated protein deubiquitination (GO:0035520)2.70648492
106positive regulation of interleukin-1 beta production (GO:0032731)2.70563165
107positive thymic T cell selection (GO:0045059)2.70422388
108positive regulation of interferon-gamma biosynthetic process (GO:0045078)2.70370012
109dendritic cell migration (GO:0036336)2.69918275
110response to protozoan (GO:0001562)2.66080906
111negative regulation of interleukin-17 production (GO:0032700)2.65954610
112regulation of germinal center formation (GO:0002634)2.64013238
113regulation of interleukin-12 biosynthetic process (GO:0045075)2.63360523
114immunoglobulin mediated immune response (GO:0016064)2.63108489
115germinal center formation (GO:0002467)2.62440464
116T-helper 1 type immune response (GO:0042088)2.62135832
117neutrophil mediated immunity (GO:0002446)2.61494100
118macrophage activation (GO:0042116)2.60444606
119positive regulation of type 2 immune response (GO:0002830)2.59973389
120modulation by symbiont of host cellular process (GO:0044068)2.59879821
121positive regulation of chemokine biosynthetic process (GO:0045080)2.59543496
122regulation of fever generation (GO:0031620)2.58252307
123nuclear pore complex assembly (GO:0051292)2.57516562
124regulation of chromatin silencing (GO:0031935)2.56562166
125regulation of T-helper 1 cell differentiation (GO:0045625)2.51275111
126regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.49306100
127detection of molecule of bacterial origin (GO:0032490)2.48878199
128positive regulation of interleukin-1 production (GO:0032732)2.48875619
129negative regulation of mast cell activation (GO:0033004)2.48873749
130myeloid dendritic cell activation (GO:0001773)2.48401721
131positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.46086675
132negative regulation of DNA-dependent DNA replication (GO:2000104)2.45159426
133regulation of interleukin-12 production (GO:0032655)2.44720371
134natural killer cell mediated immunity (GO:0002228)2.42976134
135natural killer cell mediated cytotoxicity (GO:0042267)2.42976134
136regulation of activation of Janus kinase activity (GO:0010533)2.42296913
137pore complex assembly (GO:0046931)2.41940957
138regulation of alpha-beta T cell proliferation (GO:0046640)2.41577776
139regulation of nuclear cell cycle DNA replication (GO:0033262)2.38332084
140histone H3-K9 demethylation (GO:0033169)2.38304390
141positive regulation of response to biotic stimulus (GO:0002833)2.37132338
142regulation of antigen processing and presentation (GO:0002577)2.36528343
143negative regulation of interleukin-12 production (GO:0032695)2.36249731
144positive regulation of T cell chemotaxis (GO:0010820)2.35689774
145regulation of T cell chemotaxis (GO:0010819)2.35689774
146cellular response to type I interferon (GO:0071357)2.34008344
147type I interferon signaling pathway (GO:0060337)2.34008344
148myeloid dendritic cell differentiation (GO:0043011)2.33915506
149positive regulation of alpha-beta T cell proliferation (GO:0046641)2.33053676
150monocyte chemotaxis (GO:0002548)2.32216119
151response to type I interferon (GO:0034340)2.32209718
152regulation of interleukin-1 secretion (GO:0050704)2.31853457
153replication fork processing (GO:0031297)2.31303322
154positive regulation of leukocyte apoptotic process (GO:2000108)2.31217775
155CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.30483970
156T-helper cell differentiation (GO:0042093)2.30483970
157histone lysine demethylation (GO:0070076)2.29393696
158histone demethylation (GO:0016577)2.28979711
159myeloid cell activation involved in immune response (GO:0002275)2.27754135
160detection of other organism (GO:0098543)2.27663262
161positive regulation of defense response to virus by host (GO:0002230)2.26966284
162CD4-positive, alpha-beta T cell differentiation (GO:0043367)2.26343733
163interferon-gamma-mediated signaling pathway (GO:0060333)2.26295819
164dendritic cell chemotaxis (GO:0002407)2.25900028
165lipopolysaccharide-mediated signaling pathway (GO:0031663)2.25777985

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human4.67765394
2IRF8_22096565_ChIP-ChIP_GC-B_Human4.15367965
3IRF8_21731497_ChIP-ChIP_J774_Mouse3.68160100
4FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.43106320
5E2F7_22180533_ChIP-Seq_HELA_Human3.34279379
6SALL1_21062744_ChIP-ChIP_HESCs_Human3.20808801
7STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.98082334
8EGR1_19374776_ChIP-ChIP_THP-1_Human2.86731944
9SMAD_19615063_ChIP-ChIP_OVARY_Human2.84331549
10IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.66129529
11IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.65415140
12VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.49906889
13GBX2_23144817_ChIP-Seq_PC3_Human2.48401807
14STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.47939654
15Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.42649385
16BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.35540047
17SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.34890660
18IRF8_27001747_Chip-Seq_BMDM_Mouse2.34724108
19GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.03357523
20TP63_19390658_ChIP-ChIP_HaCaT_Human2.02384908
21GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.00217891
22FLI1_27457419_Chip-Seq_LIVER_Mouse1.90732320
23CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.90659932
24MYB_26560356_Chip-Seq_TH2_Human1.87334469
25* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.83739188
26POU3F2_20337985_ChIP-ChIP_501MEL_Human1.74774415
27PCGF2_27294783_Chip-Seq_ESCs_Mouse1.72886912
28NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.65531349
29RUNX_20019798_ChIP-Seq_JUKART_Human1.61691924
30SUZ12_27294783_Chip-Seq_NPCs_Mouse1.60122466
31* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.58017428
32PCGF2_27294783_Chip-Seq_NPCs_Mouse1.57483055
33CDX2_19796622_ChIP-Seq_MESCs_Mouse1.56219153
34* SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.55254752
35NFE2_27457419_Chip-Seq_LIVER_Mouse1.54031205
36GATA3_27048872_Chip-Seq_THYMUS_Human1.52164076
37KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.50480254
38KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.50480254
39KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.50480254
40* E2F1_18555785_Chip-Seq_ESCs_Mouse1.50323469
41ZFP57_27257070_Chip-Seq_ESCs_Mouse1.49907755
42* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.49319292
43GATA1_22025678_ChIP-Seq_K562_Human1.46254085
44SPI1_23547873_ChIP-Seq_NB4_Human1.45219033
45* NANOG_18555785_Chip-Seq_ESCs_Mouse1.44166156
46ER_23166858_ChIP-Seq_MCF-7_Human1.43255839
47MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.41858649
48GATA3_26560356_Chip-Seq_TH2_Human1.39787374
49GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.35186268
50MYB_26560356_Chip-Seq_TH1_Human1.34397124
51EZH2_27294783_Chip-Seq_NPCs_Mouse1.32057301
52TAF15_26573619_Chip-Seq_HEK293_Human1.31555280
53* SUZ12_18555785_Chip-Seq_ESCs_Mouse1.30918886
54EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.30749405
55AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.30492882
56TCF4_18268006_ChIP-ChIP_LS174T_Human1.27817724
57RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.26586710
58* STAT3_18555785_Chip-Seq_ESCs_Mouse1.26518749
59HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.26271166
60* CMYC_18555785_Chip-Seq_ESCs_Mouse1.25958227
61* P53_22387025_ChIP-Seq_ESCs_Mouse1.25294707
62VDR_24787735_ChIP-Seq_THP-1_Human1.24714955
63PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.24638452
64SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.24497684
65RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.24482492
66* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.23832813
67STAT4_19710469_ChIP-ChIP_TH1__Mouse1.22515047
68FUS_26573619_Chip-Seq_HEK293_Human1.21819377
69IGF1R_20145208_ChIP-Seq_DFB_Human1.21119442
70P300_19829295_ChIP-Seq_ESCs_Human1.20831545
71* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.20577343
72* SMAD4_21799915_ChIP-Seq_A2780_Human1.20223778
73STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.19094227
74SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.19057887
75EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.18222871
76FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.18061091
77* NMYC_18555785_Chip-Seq_ESCs_Mouse1.17962855
78PU_27001747_Chip-Seq_BMDM_Mouse1.17892426
79PU1_27457419_Chip-Seq_LIVER_Mouse1.17099387
80* FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.15494230
81SMRT_27268052_Chip-Seq_Bcells_Human1.14787916
82LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.14228786
83* P300_18555785_Chip-Seq_ESCs_Mouse1.13522213
84ESR1_20079471_ChIP-ChIP_T-47D_Human1.12844568
85AHR_22903824_ChIP-Seq_MCF-7_Human1.12306379
86* SOX2_18555785_Chip-Seq_ESCs_Mouse1.12240268
87RUNX1_27457419_Chip-Seq_LIVER_Mouse1.12080435
88RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.11468405
89VDR_24763502_ChIP-Seq_THP-1_Human1.11458099
90* OCT4_18555785_Chip-Seq_ESCs_Mouse1.11441354
91SCL_19346495_ChIP-Seq_HPC-7_Human1.10423991
92NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.08351325
93BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.08124348
94ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.08048281
95FLI1_21867929_ChIP-Seq_TH2_Mouse1.07660304
96PRDM14_20953172_ChIP-Seq_ESCs_Human1.06977252
97MYB_21317192_ChIP-Seq_ERMYB_Mouse1.06257171
98BCAT_22108803_ChIP-Seq_LS180_Human1.05286967
99PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.04993482
100STAT3_23295773_ChIP-Seq_U87_Human1.04921143
101TCF4_23295773_ChIP-Seq_U87_Human1.04720843
102PIAS1_25552417_ChIP-Seq_VCAP_Human1.03623747
103TP53_16413492_ChIP-PET_HCT116_Human1.03329426
104TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.03232716
105ZFX_18555785_Chip-Seq_ESCs_Mouse1.02956013
106GATA1_19941827_ChIP-Seq_MEL_Mouse1.02383346
107* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.01940202
108CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.00130383
109ESRRB_18555785_Chip-Seq_ESCs_Mouse1.00097526
110OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.99848260
111GATA2_21666600_ChIP-Seq_HMVEC_Human0.99214224
112CTCF_18555785_Chip-Seq_ESCs_Mouse0.99028141
113* BRD4_27068464_Chip-Seq_AML-cells_Mouse0.98896729
114EWS_26573619_Chip-Seq_HEK293_Human0.98401777
115KLF4_18555785_Chip-Seq_ESCs_Mouse0.97644756
116CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97196908
117GATA2_19941826_ChIP-Seq_K562_Human0.96482809
118SPI1_23127762_ChIP-Seq_K562_Human0.96209338
119CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.95871561
120MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.95857798
121E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.95790320
122POU5F1_16153702_ChIP-ChIP_HESCs_Human0.95415468
123RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.95028086
124SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.94340037
125AR_21572438_ChIP-Seq_LNCaP_Human0.94235461
126RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.94225609
127OCT4_21477851_ChIP-Seq_ESCs_Mouse0.93562062
128* TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91060225
129* POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.91060225
130TP63_23658742_ChIP-Seq_EP156T_Human0.90115046
131* ARNT_22903824_ChIP-Seq_MCF-7_Human0.89892109
132KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.89737945
133MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.89664383
134STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.89655016
135EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.89590588
136GATA1_19941826_ChIP-Seq_K562_Human0.89580687

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation5.30845469
2MP0001835_abnormal_antigen_presentation3.84986379
3MP0005671_abnormal_response_to2.46104464
4MP0003787_abnormal_imprinting2.44198849
5MP0002148_abnormal_hypersensitivity_rea2.30680473
6MP0000371_diluted_coat_color2.14327033
7MP0008057_abnormal_DNA_replication2.12020942
8MP0009785_altered_susceptibility_to2.11514765
9MP0005387_immune_system_phenotype2.10700598
10MP0001790_abnormal_immune_system2.10700598
11MP0000015_abnormal_ear_pigmentation2.10077750
12MP0003172_abnormal_lysosome_physiology2.07598784
13MP0005171_absent_coat_pigmentation2.04984763
14MP0002419_abnormal_innate_immunity2.02604510
15MP0003303_peritoneal_inflammation1.99467684
16MP0003941_abnormal_skin_development1.96868823
17MP0003436_decreased_susceptibility_to1.94228720
18MP0005000_abnormal_immune_tolerance1.88331719
19MP0001800_abnormal_humoral_immune1.88191711
20MP0004510_myositis1.85568796
21MP0002452_abnormal_antigen_presenting1.84041286
22MP0002006_tumorigenesis1.75726752
23MP0005076_abnormal_cell_differentiation1.74757337
24MP0002277_abnormal_respiratory_mucosa1.73743942
25MP0000465_gastrointestinal_hemorrhage1.71243789
26MP0000685_abnormal_immune_system1.70016314
27MP0005075_abnormal_melanosome_morpholog1.69541871
28MP0002723_abnormal_immune_serum1.68841721
29MP0005025_abnormal_response_to1.66558125
30MP0003724_increased_susceptibility_to1.66005283
31MP0010307_abnormal_tumor_latency1.65694772
32MP0005174_abnormal_tail_pigmentation1.65408986
33MP0002254_reproductive_system_inflammat1.60681280
34MP0002009_preneoplasia1.60539500
35MP0002396_abnormal_hematopoietic_system1.59725703
36MP0003656_abnormal_erythrocyte_physiolo1.56287731
37MP0001819_abnormal_immune_cell1.54457394
38MP0008058_abnormal_DNA_repair1.54234429
39MP0002420_abnormal_adaptive_immunity1.48970666
40MP0002166_altered_tumor_susceptibility1.46662159
41MP0004883_abnormal_blood_vessel1.44694042
42MP0003866_abnormal_defecation1.41747483
43MP0003136_yellow_coat_color1.40635431
44MP0006292_abnormal_olfactory_placode1.35965155
45MP0005310_abnormal_salivary_gland1.35008041
46MP0001188_hyperpigmentation1.34230482
47MP0002075_abnormal_coat/hair_pigmentati1.33388359
48MP0006082_CNS_inflammation1.33283389
49MP0003448_altered_tumor_morphology1.30223746
50MP0000383_abnormal_hair_follicle1.30159542
51MP0005367_renal/urinary_system_phenotyp1.28228790
52MP0000516_abnormal_urinary_system1.28228790
53MP0003191_abnormal_cellular_cholesterol1.27809864
54MP0003183_abnormal_peptide_metabolism1.26956583
55MP0001186_pigmentation_phenotype1.25045329
56MP0002638_abnormal_pupillary_reflex1.23113037
57MP0004130_abnormal_muscle_cell1.23021080
58MP0003252_abnormal_bile_duct1.21765737
59MP0002398_abnormal_bone_marrow1.18968392
60MP0001853_heart_inflammation1.18759231
61MP0002405_respiratory_system_inflammati1.18612482
62MP0008004_abnormal_stomach_pH1.17738548
63MP0001851_eye_inflammation1.16874294
64MP0003828_pulmonary_edema1.16848013
65MP0003111_abnormal_nucleus_morphology1.12660125
66MP0005164_abnormal_response_to1.12128824
67MP0010094_abnormal_chromosome_stability1.11840354
68MP0000716_abnormal_immune_system1.09548235
69MP0005645_abnormal_hypothalamus_physiol1.08694487
70MP0002095_abnormal_skin_pigmentation1.07776582
71MP0003045_fibrosis1.07674714
72MP0004484_altered_response_of1.06482267
73MP0004782_abnormal_surfactant_physiolog1.05044406
74MP0008260_abnormal_autophagy1.03589177
75MP0003690_abnormal_glial_cell1.02561535
76MP0002332_abnormal_exercise_endurance1.02420280
77MP0000427_abnormal_hair_cycle1.01577975
78MP0001984_abnormal_olfaction1.00217398
79MP0009764_decreased_sensitivity_to0.99836892
80MP0006054_spinal_hemorrhage0.99726936
81MP0010155_abnormal_intestine_physiology0.98597715
82MP0004808_abnormal_hematopoietic_stem0.97691669
83MP0003121_genomic_imprinting0.96723425
84MP0002877_abnormal_melanocyte_morpholog0.96584389
85MP0008469_abnormal_protein_level0.96046890
86MP0005464_abnormal_platelet_physiology0.94071446
87MP0005409_darkened_coat_color0.91977658
88MP0003950_abnormal_plasma_membrane0.90696628
89MP0002998_abnormal_bone_remodeling0.88915784
90MP0003763_abnormal_thymus_physiology0.88872770
91MP0001545_abnormal_hematopoietic_system0.88863625
92MP0005397_hematopoietic_system_phenotyp0.88863625
93MP0009278_abnormal_bone_marrow0.88540595
94MP0005646_abnormal_pituitary_gland0.88443519
95MP0001845_abnormal_inflammatory_respons0.85846868
96MP0000627_abnormal_mammary_gland0.84115160
97MP0002876_abnormal_thyroid_physiology0.83898227
98MP0003195_calcinosis0.83323850
99MP0008961_abnormal_basal_metabolism0.83046178
100MP0009697_abnormal_copulation0.82773179
101MP0010352_gastrointestinal_tract_polyps0.82336224
102MP0008007_abnormal_cellular_replicative0.82203658
103MP0009765_abnormal_xenobiotic_induced0.81473526
104MP0004381_abnormal_hair_follicle0.81054422
105MP0008877_abnormal_DNA_methylation0.80352016
106MP0005451_abnormal_body_composition0.80115608
107MP0002429_abnormal_blood_cell0.79569836
108MP0002722_abnormal_immune_system0.79018441
109MP0009115_abnormal_fat_cell0.78715789
110MP0001873_stomach_inflammation0.78568352
111MP0009333_abnormal_splenocyte_physiolog0.78056497
112MP0000249_abnormal_blood_vessel0.77883020
113MP0000689_abnormal_spleen_morphology0.77213469
114MP0005167_abnormal_blood-brain_barrier0.76180865
115MP0003646_muscle_fatigue0.75434309
116MP0001293_anophthalmia0.75299297
117MP0005248_abnormal_Harderian_gland0.75243017
118MP0001533_abnormal_skeleton_physiology0.75021610
119MP0000858_altered_metastatic_potential0.74649586
120MP0009763_increased_sensitivity_to0.74072409
121MP0000703_abnormal_thymus_morphology0.73990346
122MP0004947_skin_inflammation0.73013384
123MP0001986_abnormal_taste_sensitivity0.72770890
124MP0002138_abnormal_hepatobiliary_system0.71903000
125MP0002928_abnormal_bile_duct0.70890368
126MP0003300_gastrointestinal_ulcer0.70432191
127MP0003221_abnormal_cardiomyocyte_apopto0.70430049
128MP0002098_abnormal_vibrissa_morphology0.69153313
129MP0005253_abnormal_eye_physiology0.68901493
130MP0004264_abnormal_extraembryonic_tissu0.68320937
131MP0003077_abnormal_cell_cycle0.67907603
132MP0003075_altered_response_to0.66800223
133MP0010678_abnormal_skin_adnexa0.64128985
134MP0000604_amyloidosis0.61737046
135MP0001663_abnormal_digestive_system0.58681342
136MP0002132_abnormal_respiratory_system0.57924831

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)3.95635919
2Genetic anticipation (HP:0003743)3.85274436
3Chromsome breakage (HP:0040012)3.77930101
4Optic neuritis (HP:0100653)3.74307091
5Retrobulbar optic neuritis (HP:0100654)3.74307091
6Abnormality of the nasal septum (HP:0000419)3.62319292
7Abnormality of T cell number (HP:0011839)3.59041338
8Abnormal delayed hypersensitivity skin test (HP:0002963)3.58815542
9Recurrent abscess formation (HP:0002722)3.58434438
10T lymphocytopenia (HP:0005403)3.58237661
11Abnormality of the fingertips (HP:0001211)3.54257005
12Gastrointestinal infarctions (HP:0005244)3.32023298
13Prolonged bleeding time (HP:0003010)3.27295872
14Recurrent bacterial skin infections (HP:0005406)3.15909119
15Eczematoid dermatitis (HP:0000976)3.15202192
16Spontaneous hematomas (HP:0007420)3.13190910
17Parkinsonism with favorable response to dopaminergic medication (HP:0002548)3.08755153
18Encephalitis (HP:0002383)3.04141361
19Meningitis (HP:0001287)3.02000998
20Hemoptysis (HP:0002105)3.00598778
21Myositis (HP:0100614)2.96977951
22* Gingival bleeding (HP:0000225)2.93910165
23Orchitis (HP:0100796)2.92835266
24Leukocytosis (HP:0001974)2.89756539
25Lip pit (HP:0100267)2.81514172
26Prostate neoplasm (HP:0100787)2.78250817
27Mediastinal lymphadenopathy (HP:0100721)2.76661737
28Ectopic kidney (HP:0000086)2.76025669
29Progressive cerebellar ataxia (HP:0002073)2.67038822
30Congenital stationary night blindness (HP:0007642)2.66663496
31* Epistaxis (HP:0000421)2.63496024
32Abnormality of T cells (HP:0002843)2.62072047
33Abnormality of the columella (HP:0009929)2.61419989
34Papillary thyroid carcinoma (HP:0002895)2.58465143
35Gingivitis (HP:0000230)2.55923436
36* Chest pain (HP:0100749)2.52144134
37Submucous cleft hard palate (HP:0000176)2.51449030
38Absent frontal sinuses (HP:0002688)2.48188036
39Stomatitis (HP:0010280)2.46606590
40Urticaria (HP:0001025)2.45806672
41Periodontitis (HP:0000704)2.45113266
42Gangrene (HP:0100758)2.43313807
43Slow saccadic eye movements (HP:0000514)2.43090952
44* Arterial thrombosis (HP:0004420)2.39537725
45Hypochromic microcytic anemia (HP:0004840)2.39259827
46Urethral obstruction (HP:0000796)2.38881991
47Autoimmune hemolytic anemia (HP:0001890)2.38565580
48Postural instability (HP:0002172)2.38147832
49Clubbing of toes (HP:0100760)2.36140709
50Peritonitis (HP:0002586)2.34450774
51Recurrent fungal infections (HP:0002841)2.33694810
52Stomach cancer (HP:0012126)2.29449085
53Abnormality of the pleura (HP:0002103)2.27883980
54Gaze-evoked nystagmus (HP:0000640)2.25495086
55Pulmonary embolism (HP:0002204)2.24819325
56Depressed nasal tip (HP:0000437)2.24255304
57Increased IgM level (HP:0003496)2.23830692
58Intestinal fistula (HP:0100819)2.21616126
59Premature loss of primary teeth (HP:0006323)2.21478579
60Abnormality of eosinophils (HP:0001879)2.18952353
61Abnormal hair whorl (HP:0010721)2.18786162
62Recurrent bronchitis (HP:0002837)2.18645474
63Keratoconjunctivitis (HP:0001096)2.18362323
64Abnormality of the renal collecting system (HP:0004742)2.17957817
65Aplasia cutis congenita (HP:0001057)2.16081515
66Duplicated collecting system (HP:0000081)2.14969574
67Keratoconjunctivitis sicca (HP:0001097)2.12835079
68Neoplasm of the oral cavity (HP:0100649)2.12805781
69Widely spaced teeth (HP:0000687)2.12355099
70Inflammation of the large intestine (HP:0002037)2.12325088
71Increased IgE level (HP:0003212)2.12266577
72Anorexia (HP:0002039)2.12064604
73Recurrent cutaneous fungal infections (HP:0011370)2.11878606
74Chronic mucocutaneous candidiasis (HP:0002728)2.11878606
75Abnormality of T cell physiology (HP:0011840)2.09668337
76Pulmonary infiltrates (HP:0002113)2.08308395
77Autoimmune thrombocytopenia (HP:0001973)2.08230257
78Agnosia (HP:0010524)2.07832323
79Anal stenosis (HP:0002025)2.07785418
80Deep philtrum (HP:0002002)2.07489045
81Granulocytopenia (HP:0001913)2.06811119
82Viral hepatitis (HP:0006562)2.03751092
83Pustule (HP:0200039)2.02682644
84Alveolar cell carcinoma (HP:0006519)2.02438758
85White forelock (HP:0002211)2.02396967
86Panhypogammaglobulinemia (HP:0003139)2.01583234
87Thick nail (HP:0001805)2.01180607
88Hyperventilation (HP:0002883)2.01090723
89Fair hair (HP:0002286)1.99852946
90Neoplasm of the adrenal cortex (HP:0100641)1.99833553
91Episodic fever (HP:0001954)1.99687173
92Subacute progressive viral hepatitis (HP:0006572)1.99625611
93Abnormality of incisor morphology (HP:0011063)1.97249899
94Colitis (HP:0002583)1.95114570
95Osteomyelitis (HP:0002754)1.93717173
96Dysmetric saccades (HP:0000641)1.93532913
97Abnormality of macrophages (HP:0004311)1.93417374
98Neoplasm of the tracheobronchial system (HP:0100552)1.92832476
99Thyroiditis (HP:0100646)1.92691207
100Aplasia/Hypoplasia of the uvula (HP:0010293)1.91469802
101Hypochromic anemia (HP:0001931)1.89965932
102Midline defect of the nose (HP:0004122)1.89250186
103Hematochezia (HP:0002573)1.88495798
104Febrile seizures (HP:0002373)1.87815634
105Petechiae (HP:0000967)1.86872557
106Large earlobe (HP:0009748)1.86794306
107Generalized hypopigmentation of hair (HP:0011358)1.86424849
108Vasculitis (HP:0002633)1.86096436
109Abnormality of chromosome stability (HP:0003220)1.85806646
110Abnormality of the frontal sinuses (HP:0002687)1.85213933
111Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.85002579
112Facial diplegia (HP:0001349)1.84425033
113Acute myeloid leukemia (HP:0004808)1.84421717
114Recurrent viral infections (HP:0004429)1.83410255
115Syringomyelia (HP:0003396)1.83052217
116Spinal cord lesions (HP:0100561)1.83052217
117Abnormality of the endocardium (HP:0004306)1.82653642
118Gastrointestinal inflammation (HP:0004386)1.82311887
119Recurrent skin infections (HP:0001581)1.81861276
120Acute hepatic failure (HP:0006554)1.81844740
121Keratitis (HP:0000491)1.81346615
122Abnormality of the peritoneum (HP:0002585)1.80501755
123Narrow palate (HP:0000189)1.79733939
124Chronic diarrhea (HP:0002028)1.79245508
125Abnormality of the incisor (HP:0000676)1.78756290
126Cellulitis (HP:0100658)1.77370410
127Amyloidosis (HP:0011034)1.77303156
128* Vertigo (HP:0002321)1.77193522
129Abnormal platelet volume (HP:0011876)1.76901609
130Adactyly (HP:0009776)1.76164939
131Hemiplegia (HP:0002301)1.75925166
132Abnormality of DNA repair (HP:0003254)1.75788625
133Abnormality of the labia minora (HP:0012880)1.74961408
134Increased number of teeth (HP:0011069)1.74280233
135Recurrent gram-negative bacterial infections (HP:0005420)1.73976633
136Skull defect (HP:0001362)1.73817144
137Papilledema (HP:0001085)1.73632856
138Agammaglobulinemia (HP:0004432)1.73495859
139Trigonocephaly (HP:0000243)1.73019819
140Recurrent pneumonia (HP:0006532)1.72976273
141Protruding tongue (HP:0010808)1.70266342
142Meckel diverticulum (HP:0002245)1.68604892
143Eosinophilia (HP:0001880)1.68428260
144Broad face (HP:0000283)1.67604923
145Long eyelashes (HP:0000527)1.67457910
146Volvulus (HP:0002580)1.65120755
147Patchy hypopigmentation of hair (HP:0011365)1.65027653
148Leukopenia (HP:0001882)1.64054182
149Ectropion (HP:0000656)1.64041758
150Hip dysplasia (HP:0001385)1.63263637
151Pulmonary artery stenosis (HP:0004415)1.62074930
152Elevated erythrocyte sedimentation rate (HP:0003565)1.61467312
153Glioma (HP:0009733)1.61306274
154Albinism (HP:0001022)1.61081344
155Abnormality of the ileum (HP:0001549)1.61030759
156Chronic obstructive pulmonary disease (HP:0006510)1.59946081
157Obstructive lung disease (HP:0006536)1.59946081
158Hypoplastic ischia (HP:0003175)1.59901542
159Basal ganglia calcification (HP:0002135)1.56422064
160Wide nose (HP:0000445)1.55306298
161IgA deficiency (HP:0002720)1.54565661
162Abnormality of the prostate (HP:0008775)1.53332836
163Abnormality of the preputium (HP:0100587)1.52866140
164Aplasia/Hypoplasia of the fovea (HP:0008060)1.52676171

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K144.56675335
2AKT33.41125440
3ZAK3.39374345
4IRAK32.98277383
5CDK122.93406705
6BRD42.41818858
7IRAK42.39799160
8TXK2.33950401
9PIK3CG2.25498462
10SGK22.04351725
11IKBKB2.02364089
12RIPK41.95805018
13CHUK1.94644344
14IKBKE1.93425652
15FES1.84353974
16SIK31.83218844
17EIF2AK21.83125210
18JAK31.82803050
19INSRR1.78679951
20EPHA21.75588600
21JAK11.71534896
22MAP2K31.70952815
23YES11.70185783
24GRK61.67625227
25BMPR21.63671689
26MAP3K131.60149256
27SGK31.58805988
28TYK21.54651431
29ERBB31.52313270
30EPHA31.42553823
31CDK191.38477746
32FGFR31.35553997
33ZAP701.34244530
34FGR1.31994741
35TNK21.31718962
36CAMK1D1.30398050
37MATK1.27315302
38MAP3K21.21278026
39OXSR11.20239918
40NUAK11.18893569
41CASK1.17050602
42PIM11.16914261
43PRPF4B1.15033569
44ACVR1B1.13434673
45ATR1.11762718
46MAP3K71.11493748
47WNK11.08794679
48MKNK21.07153414
49MAP3K61.03200549
50CAMK1G1.03142203
51CDK31.03012457
52SGK4940.97806457
53SGK2230.97806457
54PTK2B0.97008992
55TEC0.96903387
56BLK0.96678677
57TBK10.95833562
58CAMKK20.93064518
59KIT0.88118141
60MARK20.80096794
61MAPK70.79199129
62HCK0.78237023
63MAP2K40.76258823
64MARK30.76191160
65NEK60.75797843
66STK40.75085315
67TAOK30.74872040
68MAP4K20.74786943
69PDK10.74498243
70SGK10.73819880
71ADRBK20.73779716
72MKNK10.72717824
73MAP3K50.71734846
74CLK10.71582040
75TTK0.71178703
76PIK3CA0.69002399
77ATM0.68931493
78CHEK20.66234540
79PBK0.65410502
80ERBB20.64986223
81STK38L0.64517510
82FRK0.63710320
83MAP3K40.62745048
84STK110.62116798
85TNIK0.61440743
86GRK70.60621516
87MAP3K30.58590221
88EPHB10.56810450
89SYK0.56488046
90CAMK40.56275699
91MAP3K10.55326433
92PRKCQ0.55263291
93TAOK10.54846847
94BMPR1B0.54126522
95SRPK10.53646737
96LYN0.52658262
97LCK0.52613531
98MAP4K10.52089499
99RPS6KB10.52023314
100WNK30.51738245
101SIK20.51243286
102AKT10.49534980
103ITK0.49389597
104CDC42BPA0.48995255
105IRAK10.48688302
106PLK30.48478419
107CSK0.47985161
108BTK0.47873292
109MAPK140.46953346
110ADRBK10.46383675
111CSF1R0.46132251
112TGFBR20.45892588
113HIPK20.45558368
114PLK40.45264117
115MELK0.45138282
116RET0.45060637
117PLK20.45046527
118JAK20.44805150
119TRPM70.44518797
120STK240.43877377
121MAP2K60.42692546
122PDGFRB0.42230810
123STK100.42117352
124OBSCN0.41853970
125PAK30.41543606
126FYN0.41370582
127TAOK20.41297547
128STK380.41164660
129NLK0.40837830
130DYRK1A0.40624920
131PRKAA20.40063390
132NEK90.39658244
133PRKCE0.39647945
134CDK60.38199862
135ABL10.37517257
136RIPK10.37078806
137GSK3B0.35763044
138GRK10.35568024
139PKN10.35438849
140IRAK20.35215231
141STK30.34995250
142MAPK10.34562342
143RPS6KA50.33549344

Predicted pathways (KEGG)

RankGene SetZ-score
1Allograft rejection_Homo sapiens_hsa053302.82228875
2Graft-versus-host disease_Homo sapiens_hsa053322.67442707
3NF-kappa B signaling pathway_Homo sapiens_hsa040642.61771190
4NOD-like receptor signaling pathway_Homo sapiens_hsa046212.24767607
5Intestinal immune network for IgA production_Homo sapiens_hsa046722.13293632
6Toll-like receptor signaling pathway_Homo sapiens_hsa046202.09226338
7Leishmaniasis_Homo sapiens_hsa051402.03547167
8Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.01734754
9Asthma_Homo sapiens_hsa053101.99514676
10Measles_Homo sapiens_hsa051621.99434130
11RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.96253425
12Type I diabetes mellitus_Homo sapiens_hsa049401.95565399
13Autoimmune thyroid disease_Homo sapiens_hsa053201.94153478
14Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.91809570
15Influenza A_Homo sapiens_hsa051641.74974668
16Herpes simplex infection_Homo sapiens_hsa051681.68739447
17Osteoclast differentiation_Homo sapiens_hsa043801.58421032
18TNF signaling pathway_Homo sapiens_hsa046681.56128364
19Platelet activation_Homo sapiens_hsa046111.53252428
20Rheumatoid arthritis_Homo sapiens_hsa053231.48654742
21Legionellosis_Homo sapiens_hsa051341.36517272
22Fanconi anemia pathway_Homo sapiens_hsa034601.36390630
23Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.31326832
24Tuberculosis_Homo sapiens_hsa051521.30296678
25Jak-STAT signaling pathway_Homo sapiens_hsa046301.29284899
26African trypanosomiasis_Homo sapiens_hsa051431.28851966
27Dorso-ventral axis formation_Homo sapiens_hsa043201.27654330
28Hematopoietic cell lineage_Homo sapiens_hsa046401.27626623
29Toxoplasmosis_Homo sapiens_hsa051451.21549221
30Primary immunodeficiency_Homo sapiens_hsa053401.21094482
31Transcriptional misregulation in cancer_Homo sapiens_hsa052021.20983727
32Non-small cell lung cancer_Homo sapiens_hsa052231.12406685
33Malaria_Homo sapiens_hsa051441.10947860
34Phototransduction_Homo sapiens_hsa047441.09923244
35Chemokine signaling pathway_Homo sapiens_hsa040621.07175332
36Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.04004174
37B cell receptor signaling pathway_Homo sapiens_hsa046621.02480171
38Apoptosis_Homo sapiens_hsa042101.01459266
39Hepatitis B_Homo sapiens_hsa051611.01073235
40Type II diabetes mellitus_Homo sapiens_hsa049300.99980562
41Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.97785258
42Viral myocarditis_Homo sapiens_hsa054160.97271082
43Hepatitis C_Homo sapiens_hsa051600.94029930
44Renal cell carcinoma_Homo sapiens_hsa052110.90349123
45T cell receptor signaling pathway_Homo sapiens_hsa046600.90118895
46Pertussis_Homo sapiens_hsa051330.88502468
47Non-homologous end-joining_Homo sapiens_hsa034500.87376064
48Neurotrophin signaling pathway_Homo sapiens_hsa047220.87323221
49Staphylococcus aureus infection_Homo sapiens_hsa051500.86907720
50Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.86297735
51Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.85998077
52Acute myeloid leukemia_Homo sapiens_hsa052210.84625091
53Notch signaling pathway_Homo sapiens_hsa043300.84477039
54MicroRNAs in cancer_Homo sapiens_hsa052060.83582369
55Small cell lung cancer_Homo sapiens_hsa052220.80680249
56Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.79936742
57Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.78001938
58Salmonella infection_Homo sapiens_hsa051320.77531387
59Phosphatidylinositol signaling system_Homo sapiens_hsa040700.76390482
60Phagosome_Homo sapiens_hsa041450.75716296
61Carbohydrate digestion and absorption_Homo sapiens_hsa049730.75502580
62Lysine degradation_Homo sapiens_hsa003100.74912891
63Thyroid hormone signaling pathway_Homo sapiens_hsa049190.74685367
64Sphingolipid signaling pathway_Homo sapiens_hsa040710.74156119
65Adherens junction_Homo sapiens_hsa045200.73619233
66Choline metabolism in cancer_Homo sapiens_hsa052310.73594845
67Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.73045571
68mTOR signaling pathway_Homo sapiens_hsa041500.72337129
69Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.72244354
70Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.71954253
71Phospholipase D signaling pathway_Homo sapiens_hsa040720.71861665
72Homologous recombination_Homo sapiens_hsa034400.71553293
73Antigen processing and presentation_Homo sapiens_hsa046120.71231562
74Epstein-Barr virus infection_Homo sapiens_hsa051690.70132563
75HTLV-I infection_Homo sapiens_hsa051660.69577569
76Systemic lupus erythematosus_Homo sapiens_hsa053220.69145286
77VEGF signaling pathway_Homo sapiens_hsa043700.67802857
78GnRH signaling pathway_Homo sapiens_hsa049120.67639027
79Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.67036456
80Inositol phosphate metabolism_Homo sapiens_hsa005620.66308855
81Prostate cancer_Homo sapiens_hsa052150.64847430
82FoxO signaling pathway_Homo sapiens_hsa040680.63659372
83One carbon pool by folate_Homo sapiens_hsa006700.63642797
84Prolactin signaling pathway_Homo sapiens_hsa049170.62957226
85Glycosaminoglycan degradation_Homo sapiens_hsa005310.61773042
86Viral carcinogenesis_Homo sapiens_hsa052030.61746743
87AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.61446768
88Ether lipid metabolism_Homo sapiens_hsa005650.59631222
89Insulin resistance_Homo sapiens_hsa049310.59181629
90Circadian rhythm_Homo sapiens_hsa047100.58803607
91Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.57499995
92Nicotine addiction_Homo sapiens_hsa050330.57342642
93Chronic myeloid leukemia_Homo sapiens_hsa052200.57043736
94p53 signaling pathway_Homo sapiens_hsa041150.56298833
95Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.55846413
96Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.55503140
97Melanoma_Homo sapiens_hsa052180.54817563
98Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.53923097
99Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.53824305
100Vitamin digestion and absorption_Homo sapiens_hsa049770.53245983
101Other glycan degradation_Homo sapiens_hsa005110.53113829
102Pancreatic cancer_Homo sapiens_hsa052120.52789980
103MAPK signaling pathway_Homo sapiens_hsa040100.52484138
104alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.52140271
105Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.51685283
106Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.51374507
107Lysosome_Homo sapiens_hsa041420.51233832
108ABC transporters_Homo sapiens_hsa020100.51188482
109Adipocytokine signaling pathway_Homo sapiens_hsa049200.50884320
110Regulation of actin cytoskeleton_Homo sapiens_hsa048100.48389346
111Pathways in cancer_Homo sapiens_hsa052000.47341231
112Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.46989880
113Longevity regulating pathway - mammal_Homo sapiens_hsa042110.46632535
114Endometrial cancer_Homo sapiens_hsa052130.46085524
115Amoebiasis_Homo sapiens_hsa051460.45960810
116SNARE interactions in vesicular transport_Homo sapiens_hsa041300.45746953
117Collecting duct acid secretion_Homo sapiens_hsa049660.45560653
118RNA degradation_Homo sapiens_hsa030180.45391944
119Glycerophospholipid metabolism_Homo sapiens_hsa005640.45086711
120Glioma_Homo sapiens_hsa052140.44064018
121HIF-1 signaling pathway_Homo sapiens_hsa040660.43857884
122Long-term depression_Homo sapiens_hsa047300.43649856
123Regulation of autophagy_Homo sapiens_hsa041400.43383988
124Cholinergic synapse_Homo sapiens_hsa047250.43185484
125Colorectal cancer_Homo sapiens_hsa052100.42798159
126Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.42392221
127cAMP signaling pathway_Homo sapiens_hsa040240.41931326
128ErbB signaling pathway_Homo sapiens_hsa040120.40195851
129Shigellosis_Homo sapiens_hsa051310.39752546
130Leukocyte transendothelial migration_Homo sapiens_hsa046700.39581000

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