TES

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Cancer-associated chromosomal changes often involve regions containing fragile sites. This gene maps to a commom fragile site on chromosome 7q31.2 designated FRA7G. This gene is similar to mouse Testin, a testosterone-responsive gene encoding a Sertoli cell secretory protein containing three LIM domains. LIM domains are double zinc-finger motifs that mediate protein-protein interactions between transcription factors, cytoskeletal proteins and signaling proteins. This protein is a negative regulator of cell growth and may act as a tumor suppressor. This scaffold protein may also play a role in cell adhesion, cell spreading and in the reorganization of the actin cytoskeleton. Multiple protein isoforms are encoded by transcript variants of this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1membrane raft organization (GO:0031579)4.12949551
2antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.94343488
3antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.94343488
4antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.93078818
5antigen processing and presentation of endogenous antigen (GO:0019883)3.85052311
6desmosome organization (GO:0002934)3.80256494
7neutrophil activation involved in immune response (GO:0002283)3.71656664
8hemidesmosome assembly (GO:0031581)3.70114540
9ribosomal small subunit assembly (GO:0000028)3.68688901
10regulation of T-helper 1 cell differentiation (GO:0045625)3.66880733
11NIK/NF-kappaB signaling (GO:0038061)3.65868434
12Arp2/3 complex-mediated actin nucleation (GO:0034314)3.55839594
13positive regulation of gamma-delta T cell activation (GO:0046645)3.53385794
14positive regulation of natural killer cell differentiation (GO:0032825)3.44532531
15sequestering of actin monomers (GO:0042989)3.44277500
16hepatocyte apoptotic process (GO:0097284)3.41228788
17regulation of metalloenzyme activity (GO:0048552)3.29623289
18bundle of His cell to Purkinje myocyte communication (GO:0086069)3.26445939
19negative regulation of cell killing (GO:0031342)3.23995364
20negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.23995364
21regulation of interleukin-8 secretion (GO:2000482)3.20136245
22positive regulation of interleukin-8 secretion (GO:2000484)3.16708953
23positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.15920937
24positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.14636982
25regulation of interleukin-12 biosynthetic process (GO:0045075)3.12258497
26myeloid dendritic cell activation (GO:0001773)3.08040750
27positive regulation of alpha-beta T cell proliferation (GO:0046641)3.07261936
28antigen processing and presentation via MHC class Ib (GO:0002475)3.06391871
29interferon-gamma production (GO:0032609)3.06029320
30regulation of T cell tolerance induction (GO:0002664)3.02598135
31necroptotic process (GO:0070266)3.00739560
32myeloid dendritic cell differentiation (GO:0043011)2.98910291
33neutrophil activation (GO:0042119)2.97707190
34keratinocyte development (GO:0003334)2.97667894
35negative thymic T cell selection (GO:0045060)2.95670575
36positive regulation of isotype switching (GO:0045830)2.91340973
37regulation of alpha-beta T cell proliferation (GO:0046640)2.89521907
38negative T cell selection (GO:0043383)2.88050095
39positive regulation of interleukin-2 production (GO:0032743)2.86252536
40positive regulation of macrophage differentiation (GO:0045651)2.85045691
41granulocyte activation (GO:0036230)2.84742413
42regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.82643120
43viral transcription (GO:0019083)2.81122470
44positive regulation of T cell mediated cytotoxicity (GO:0001916)2.81082090
45regulation of apoptotic process involved in morphogenesis (GO:1902337)2.80386331
46cytidine catabolic process (GO:0006216)2.79837939
47cytidine deamination (GO:0009972)2.79837939
48cytidine metabolic process (GO:0046087)2.79837939
49actin nucleation (GO:0045010)2.79625904
50regulation of antigen processing and presentation (GO:0002577)2.79023423
51leukocyte aggregation (GO:0070486)2.78117930
52positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.76840771
53regulation of dendritic cell antigen processing and presentation (GO:0002604)2.76437924
54positive regulation of antigen processing and presentation (GO:0002579)2.73066088
55interferon-gamma secretion (GO:0072643)2.72936241
56response to type I interferon (GO:0034340)2.71927276
57translational termination (GO:0006415)2.70936064
58cellular response to type I interferon (GO:0071357)2.70781592
59type I interferon signaling pathway (GO:0060337)2.70781592
60dendritic cell chemotaxis (GO:0002407)2.69614428
61immunoglobulin mediated immune response (GO:0016064)2.69543273
62response to interferon-beta (GO:0035456)2.68967680
63regulation of transforming growth factor beta2 production (GO:0032909)2.64516911
64regulation of RIG-I signaling pathway (GO:0039535)2.64358805
65SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.63663544
66positive regulation of interferon-alpha production (GO:0032727)2.62241883
67positive regulation of interleukin-12 production (GO:0032735)2.61310759
68regulation of regulatory T cell differentiation (GO:0045589)2.61022140
69response to muramyl dipeptide (GO:0032495)2.60930914
70cellular response to interferon-beta (GO:0035458)2.60852397
71intestinal epithelial cell development (GO:0060576)2.59972866
72response to protozoan (GO:0001562)2.59271341
73natural killer cell mediated cytotoxicity (GO:0042267)2.56769280
74natural killer cell mediated immunity (GO:0002228)2.56769280
75regulation of transforming growth factor beta1 production (GO:0032908)2.55670460
76protein targeting to ER (GO:0045047)2.55279674
77interferon-gamma-mediated signaling pathway (GO:0060333)2.54851342
78dendritic cell migration (GO:0036336)2.54787377
79dendritic cell differentiation (GO:0097028)2.54763907
80regulation of T cell mediated cytotoxicity (GO:0001914)2.54369444
81response to interleukin-15 (GO:0070672)2.54325450
82regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)2.53946628
83regulation of natural killer cell differentiation (GO:0032823)2.53639240
84cotranslational protein targeting to membrane (GO:0006613)2.53306970
85response to peptidoglycan (GO:0032494)2.52136054
86natural killer cell activation (GO:0030101)2.52000605
87positive regulation of DNA recombination (GO:0045911)2.51970489
88defense response to protozoan (GO:0042832)2.51719606
89regulation of T cell receptor signaling pathway (GO:0050856)2.51701602
90pyrimidine ribonucleoside catabolic process (GO:0046133)2.51274327
91B cell mediated immunity (GO:0019724)2.50642160
92programmed necrotic cell death (GO:0097300)2.49804421
93regulation of interferon-alpha production (GO:0032647)2.49497365
94positive regulation of T-helper cell differentiation (GO:0045624)2.48899553
95cellular response to interleukin-15 (GO:0071350)2.48247912
96regulation of necroptotic process (GO:0060544)2.48209594
97regulation of gamma-delta T cell differentiation (GO:0045586)2.48061911
98T cell selection (GO:0045058)2.47387203
99negative regulation of B cell proliferation (GO:0030889)2.46902320
100cellular response to zinc ion (GO:0071294)2.46095536
101T-helper 1 type immune response (GO:0042088)2.45392498
102ribosomal small subunit biogenesis (GO:0042274)2.45143217
103T cell migration (GO:0072678)2.44392837
104regulation of T-helper 1 type immune response (GO:0002825)2.44201772
105regulation of interleukin-2 biosynthetic process (GO:0045076)2.43918670
106cytokine biosynthetic process (GO:0042089)2.42776685
107regulation of tolerance induction (GO:0002643)2.42591940
108positive regulation of immunoglobulin mediated immune response (GO:0002891)2.40974465
109positive regulation of B cell mediated immunity (GO:0002714)2.40974465
110establishment of protein localization to endoplasmic reticulum (GO:0072599)2.40200874
111UDP-N-acetylglucosamine metabolic process (GO:0006047)2.39807494
112regulation of gamma-delta T cell activation (GO:0046643)2.39116106
113positive regulation of leukocyte mediated cytotoxicity (GO:0001912)2.37091061
114negative regulation of T cell mediated immunity (GO:0002710)2.36809906
115monocyte chemotaxis (GO:0002548)2.36364717
116positive regulation of T cell chemotaxis (GO:0010820)2.35909420
117regulation of T cell chemotaxis (GO:0010819)2.35909420
118regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.35800628
119protein localization to endoplasmic reticulum (GO:0070972)2.35232939
120T cell apoptotic process (GO:0070231)2.35013850
121ER overload response (GO:0006983)2.34976837
122leukocyte cell-cell adhesion (GO:0007159)2.34674520
123positive regulation of interleukin-17 production (GO:0032740)2.34576694
124regulation of T-helper cell differentiation (GO:0045622)2.34292296
125tolerance induction (GO:0002507)2.33814827
126establishment of endothelial barrier (GO:0061028)2.33722840
127positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)2.33582420
128regulation of protein heterodimerization activity (GO:0043497)2.32944269
129T cell activation involved in immune response (GO:0002286)2.32738310
130tyrosine phosphorylation of STAT protein (GO:0007260)2.31745810
131regulation of B cell receptor signaling pathway (GO:0050855)2.31725043
132negative regulation of viral genome replication (GO:0045071)2.31703510
133negative regulation of stress fiber assembly (GO:0051497)2.31617951
134ribosome assembly (GO:0042255)2.31116859
135regulation of B cell differentiation (GO:0045577)2.30229393
136JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.29888771
137necrotic cell death (GO:0070265)2.28957750
138detection of other organism (GO:0098543)2.25168262
139detection of bacterium (GO:0016045)2.25076787
140wound healing, spreading of epidermal cells (GO:0035313)2.23683233
141modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.22850968
142positive regulation by organism of defense response of other organism involved in symbiotic interact2.22850968
143modulation by symbiont of host immune response (GO:0052553)2.22850968
144positive regulation by symbiont of host defense response (GO:0052509)2.22850968
145modulation by symbiont of host defense response (GO:0052031)2.22850968
146modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.22850968
147mammary gland epithelial cell proliferation (GO:0033598)2.21754478
148positive T cell selection (GO:0043368)2.21526293
149keratinocyte proliferation (GO:0043616)2.21141859
150negative regulation of glycoprotein biosynthetic process (GO:0010561)2.19604257
151nucleotide-binding oligomerization domain containing signaling pathway (GO:0070423)2.19501799
152regulation of leukocyte mediated cytotoxicity (GO:0001910)2.18008400
153negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.17635981
154G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.17444365
155leukocyte degranulation (GO:0043299)2.15463945
156cytokine metabolic process (GO:0042107)2.15087019
157hypotonic response (GO:0006971)2.14700830
158organelle membrane fusion (GO:0090174)2.14609842
159regulation of thymocyte apoptotic process (GO:0070243)2.14171031
160DNA deamination (GO:0045006)2.12695850
161positive regulation of cell killing (GO:0031343)2.11831856
162lymph node development (GO:0048535)2.11442139

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human4.70793437
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.36931208
3IRF8_21731497_ChIP-ChIP_J774_Mouse3.73805147
4TP63_17297297_ChIP-ChIP_HaCaT_Human3.69067225
5E2F7_22180533_ChIP-Seq_HELA_Human3.61489344
6IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.58751659
7EGR1_19374776_ChIP-ChIP_THP-1_Human3.33800311
8SMAD_19615063_ChIP-ChIP_OVARY_Human3.16386423
9* STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.08332893
10BP1_19119308_ChIP-ChIP_Hs578T_Human3.03441992
11SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.88318488
12* MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.75274886
13STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.73241289
14IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.71855909
15* STAT4_19710469_ChIP-ChIP_TH1__Mouse2.66275856
16MYB_21317192_ChIP-Seq_ERMYB_Mouse2.38353885
17RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.38081841
18IRF8_27001747_Chip-Seq_BMDM_Mouse2.36368007
19NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.29790416
20SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.28496255
21SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.27454043
22ELF1_17652178_ChIP-ChIP_JURKAT_Human2.23541049
23SPI1_23547873_ChIP-Seq_NB4_Human2.22601431
24* MYB_26560356_Chip-Seq_TH2_Human2.14618682
25GATA2_21666600_ChIP-Seq_HMVEC_Human2.08247265
26ASXL1_24218140_ChIP-Seq_BMDM_Mouse2.01007156
27* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.91758793
28NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.89963030
29CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.85892387
30MAF_26560356_Chip-Seq_TH1_Human1.85455755
31MYB_26560356_Chip-Seq_TH1_Human1.85067850
32TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.81597816
33FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.81539219
34TRIM28_21343339_ChIP-Seq_HEK293_Human1.80287376
35RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.77393492
36ELK1_19687146_ChIP-ChIP_HELA_Human1.76823902
37NOTCH1_21737748_ChIP-Seq_TLL_Human1.76416531
38EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.75302016
39GABP_17652178_ChIP-ChIP_JURKAT_Human1.73932369
40HIF1A_21447827_ChIP-Seq_MCF-7_Human1.73309870
41* PPAR_26484153_Chip-Seq_NCI-H1993_Human1.70044399
42MYC_18555785_ChIP-Seq_MESCs_Mouse1.69983414
43* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.66713095
44MYC_22102868_ChIP-Seq_BL_Human1.66023337
45BRD4_27068464_Chip-Seq_AML-cells_Mouse1.64979078
46RUNX1_22412390_ChIP-Seq_EML_Mouse1.63344934
47* FOXO3_23340844_ChIP-Seq_DLD1_Human1.61913944
48KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.59897314
49* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.56095886
50VDR_21846776_ChIP-Seq_THP-1_Human1.52465839
51RUNX_20019798_ChIP-Seq_JUKART_Human1.50217067
52STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.49859179
53VDR_24763502_ChIP-Seq_THP-1_Human1.48357435
54UTX_26944678_Chip-Seq_JUKART_Human1.48143733
55VDR_23849224_ChIP-Seq_CD4+_Human1.47507576
56* CJUN_26792858_Chip-Seq_BT549_Human1.47312598
57* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.46585420
58SOX2_20726797_ChIP-Seq_SW620_Human1.46170802
59SCL_19346495_ChIP-Seq_HPC-7_Human1.45681213
60HOXB4_20404135_ChIP-ChIP_EML_Mouse1.45082039
61JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.44985287
62* BRD4_25478319_ChIP-Seq_HGPS_Human1.42260834
63Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.40844560
64FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.40583568
65MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.40537002
66* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.38118237
67* CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.37312410
68E2F4_17652178_ChIP-ChIP_JURKAT_Human1.37034602
69NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.34315702
70STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.34282040
71EST1_17652178_ChIP-ChIP_JURKAT_Human1.31791632
72ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.31187817
73GATA1_22025678_ChIP-Seq_K562_Human1.30632809
74* SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.29764625
75PU_27001747_Chip-Seq_BMDM_Mouse1.29489719
76ATF3_27146783_Chip-Seq_COLON_Human1.29362348
77TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.29197150
78ESR1_21235772_ChIP-Seq_MCF-7_Human1.28369783
79* GATA4_25053715_ChIP-Seq_YYC3_Human1.28344266
80FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.28032289
81* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.25109992
82* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.25109992
83ELK1_22589737_ChIP-Seq_MCF10A_Human1.25084580
84GATA2_22383799_ChIP-Seq_G1ME_Mouse1.24916189
85GATA6_25053715_ChIP-Seq_YYC3_Human1.24244711
86GATA3_27048872_Chip-Seq_THYMUS_Human1.20892322
87CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.20167384
88ELF5_23300383_ChIP-Seq_T47D_Human1.19903748
89SALL4_18804426_ChIP-ChIP_XEN_Mouse1.17429163
90GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.17417453
91MYC_19079543_ChIP-ChIP_MESCs_Mouse1.15594511
92DCP1A_22483619_ChIP-Seq_HELA_Human1.15329716
93TFEB_21752829_ChIP-Seq_HELA_Human1.14930792
94MAF_26560356_Chip-Seq_TH2_Human1.14698682
95CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.13709105
96KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.13604204
97FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.13386891
98PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.13075823
99CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.11551048
100SOX2_27498859_Chip-Seq_STOMACH_Mouse1.11135656
101FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.10831826
102LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.10262965
103FOXM1_23109430_ChIP-Seq_U2OS_Human1.09512142
104EGR1_23403033_ChIP-Seq_LIVER_Mouse1.09100678
105P63_26484246_Chip-Seq_KERATINOCYTES_Human1.08164303
106* GATA3_24758297_ChIP-Seq_MCF-7_Human1.07851800
107* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.07376966
108HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.07268361
109NELFA_20434984_ChIP-Seq_ESCs_Mouse1.06879278
110RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.06829749
111TCF7_22412390_ChIP-Seq_EML_Mouse1.05404826
112FOXP3_21729870_ChIP-Seq_TREG_Human1.04913119
113* TP63_23658742_ChIP-Seq_EP156T_Human1.04758766
114XRN2_22483619_ChIP-Seq_HELA_Human1.04330769
115BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.04265677
116SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.03030977
117SPI1_23127762_ChIP-Seq_K562_Human1.01965481
118MYC_19030024_ChIP-ChIP_MESCs_Mouse1.01231421
119CDX2_20551321_ChIP-Seq_CACO-2_Human1.00074459
120ELK3_25401928_ChIP-Seq_HUVEC_Human0.98917934
121ETS1_20019798_ChIP-Seq_JURKAT_Human0.97788741
122VDR_24787735_ChIP-Seq_THP-1_Human0.97747701
123CREB1_15753290_ChIP-ChIP_HEK293T_Human0.96291229
124* NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.94665196
125* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.93757165
126GATA1_22383799_ChIP-Seq_G1ME_Mouse0.93073566
127MYC_18358816_ChIP-ChIP_MESCs_Mouse0.92806614
128GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.92760982
129SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.91507587
130E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.91449559
131ESR1_20079471_ChIP-ChIP_T-47D_Human0.90853886
132GATA3_26560356_Chip-Seq_TH2_Human0.90797428
133JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.89697257
134E2F1_21310950_ChIP-Seq_MCF-7_Human0.89299908
135ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.89110838
136KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.88837601
137HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.86420105
138TTF2_22483619_ChIP-Seq_HELA_Human0.85951681
139SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.85527162
140* CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.85477213
141PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.84434999
142E2F1_18555785_ChIP-Seq_MESCs_Mouse0.82861164
143* FOXM1_26456572_ChIP-Seq_MCF-7_Human0.82765498
144CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.82298647
145* EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.81636112
146FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.79911446

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation3.77002677
2MP0000685_abnormal_immune_system3.01071653
3MP0009785_altered_susceptibility_to2.99961732
4MP0005671_abnormal_response_to2.95090176
5MP0002148_abnormal_hypersensitivity_rea2.91335236
6MP0010234_abnormal_vibrissa_follicle2.69469714
7MP0003436_decreased_susceptibility_to2.68169115
8MP0005000_abnormal_immune_tolerance2.55520832
9MP0001790_abnormal_immune_system2.47214033
10MP0005387_immune_system_phenotype2.47214033
11MP0005025_abnormal_response_to2.32410631
12MP0003763_abnormal_thymus_physiology2.30322095
13MP0002166_altered_tumor_susceptibility2.28845685
14MP0002452_abnormal_antigen_presenting2.27934855
15MP0001800_abnormal_humoral_immune2.26787466
16MP0002723_abnormal_immune_serum2.18246972
17MP0001819_abnormal_immune_cell2.14737306
18MP0010352_gastrointestinal_tract_polyps2.14069866
19MP0002006_tumorigenesis2.14033651
20MP0002420_abnormal_adaptive_immunity2.13221054
21MP0002419_abnormal_innate_immunity2.06876169
22MP0010155_abnormal_intestine_physiology2.05197489
23MP0002405_respiratory_system_inflammati2.01391413
24MP0003724_increased_susceptibility_to2.00029102
25MP0009333_abnormal_splenocyte_physiolog1.98723662
26MP0004272_abnormal_basement_membrane1.94409824
27MP0004264_abnormal_extraembryonic_tissu1.93000354
28MP0002396_abnormal_hematopoietic_system1.91633113
29MP0003950_abnormal_plasma_membrane1.90014420
30MP0000858_altered_metastatic_potential1.86539602
31MP0006082_CNS_inflammation1.81957997
32MP0002398_abnormal_bone_marrow1.81037291
33MP0000490_abnormal_crypts_of1.77882600
34MP0010678_abnormal_skin_adnexa1.75431270
35MP0003300_gastrointestinal_ulcer1.75158054
36MP0000716_abnormal_immune_system1.71084824
37MP0001348_abnormal_lacrimal_gland1.69616870
38MP0001873_stomach_inflammation1.67300518
39MP0003303_peritoneal_inflammation1.67253109
40MP0001853_heart_inflammation1.66049103
41MP0004947_skin_inflammation1.63562662
42MP0003866_abnormal_defecation1.62885935
43MP0005275_abnormal_skin_tensile1.61947532
44MP0002138_abnormal_hepatobiliary_system1.61379652
45MP0004808_abnormal_hematopoietic_stem1.60493143
46MP0006054_spinal_hemorrhage1.58227933
47MP0002060_abnormal_skin_morphology1.58122485
48MP0003693_abnormal_embryo_hatching1.57348287
49MP0003191_abnormal_cellular_cholesterol1.57267910
50MP0003448_altered_tumor_morphology1.57010565
51MP0002796_impaired_skin_barrier1.55677657
52MP0005464_abnormal_platelet_physiology1.55651051
53MP0001845_abnormal_inflammatory_respons1.53635045
54MP0005310_abnormal_salivary_gland1.52344555
55MP0002877_abnormal_melanocyte_morpholog1.50489376
56MP0001216_abnormal_epidermal_layer1.46475699
57MP0002722_abnormal_immune_system1.46097195
58MP0008007_abnormal_cellular_replicative1.44951894
59MP0002429_abnormal_blood_cell1.42733890
60MP0001533_abnormal_skeleton_physiology1.38983992
61MP0000689_abnormal_spleen_morphology1.38981336
62MP0001851_eye_inflammation1.38664988
63MP0001545_abnormal_hematopoietic_system1.37898450
64MP0005397_hematopoietic_system_phenotyp1.37898450
65MP0000569_abnormal_digit_pigmentation1.32524116
66MP0005164_abnormal_response_to1.32052507
67MP0003566_abnormal_cell_adhesion1.27601047
68MP0003252_abnormal_bile_duct1.27585936
69MP0003806_abnormal_nucleotide_metabolis1.26899703
70MP0005174_abnormal_tail_pigmentation1.24729824
71MP0000703_abnormal_thymus_morphology1.24197242
72MP0004510_myositis1.23579408
73MP0000383_abnormal_hair_follicle1.15749426
74MP0002132_abnormal_respiratory_system1.14911106
75MP0008004_abnormal_stomach_pH1.13373959
76MP0005166_decreased_susceptibility_to1.12711486
77MP0009278_abnormal_bone_marrow1.12659435
78MP0002277_abnormal_respiratory_mucosa1.12151838
79MP0005023_abnormal_wound_healing1.09448526
80MP0002933_joint_inflammation1.07935398
81MP0010307_abnormal_tumor_latency1.07918735
82MP0002163_abnormal_gland_morphology1.07867118
83MP0003786_premature_aging1.06187844
84MP0004381_abnormal_hair_follicle1.06037874
85MP0000465_gastrointestinal_hemorrhage1.05969599
86MP0008057_abnormal_DNA_replication1.04331643
87MP0008469_abnormal_protein_level1.03642792
88MP0009764_decreased_sensitivity_to1.03145133
89MP0005501_abnormal_skin_physiology1.03011240
90MP0003091_abnormal_cell_migration1.01997658
91MP0003077_abnormal_cell_cycle1.01938159
92MP0002009_preneoplasia0.99622836
93MP0005076_abnormal_cell_differentiation0.97461269
94MP0002019_abnormal_tumor_incidence0.97334596
95MP0005165_increased_susceptibility_to0.96742193
96MP0002998_abnormal_bone_remodeling0.95367061
97MP0004957_abnormal_blastocyst_morpholog0.94917633
98MP0000013_abnormal_adipose_tissue0.91893881
99MP0003943_abnormal_hepatobiliary_system0.90398304
100MP0003453_abnormal_keratinocyte_physiol0.90394690
101MP0005058_abnormal_lysosome_morphology0.90340711
102MP0008260_abnormal_autophagy0.90185836
103MP0004484_altered_response_of0.89434888
104MP0004782_abnormal_surfactant_physiolog0.87387496
105MP0000371_diluted_coat_color0.83420782
106MP0010771_integument_phenotype0.82121752
107MP0005390_skeleton_phenotype0.79478021
108MP0000377_abnormal_hair_follicle0.79368443
109MP0000627_abnormal_mammary_gland0.79168701
110MP0002136_abnormal_kidney_physiology0.78538328
111MP0000343_altered_response_to0.78511131
112MP0001191_abnormal_skin_condition0.78252558
113MP0005075_abnormal_melanosome_morpholog0.77844369
114MP0000762_abnormal_tongue_morphology0.75328392
115MP0005360_urolithiasis0.74870939
116MP0009931_abnormal_skin_appearance0.74590425
117MP0003828_pulmonary_edema0.73636797
118MP0000613_abnormal_salivary_gland0.73179632
119MP0000477_abnormal_intestine_morphology0.69710060
120MP0002693_abnormal_pancreas_physiology0.68850114
121MP0000015_abnormal_ear_pigmentation0.68504645
122MP0009379_abnormal_foot_pigmentation0.68430922
123MP0003941_abnormal_skin_development0.67242879
124MP0002254_reproductive_system_inflammat0.66973798
125MP0005084_abnormal_gallbladder_morpholo0.65958879
126MP0010094_abnormal_chromosome_stability0.65468411
127MP0003795_abnormal_bone_structure0.65206702
128MP0001663_abnormal_digestive_system0.64885778
129MP0001881_abnormal_mammary_gland0.64764346
130MP0001346_abnormal_lacrimal_gland0.64754343
131MP0000313_abnormal_cell_death0.63661707
132MP0001879_abnormal_lymphatic_vessel0.63437601
133MP0002095_abnormal_skin_pigmentation0.62868601
134MP0000249_abnormal_blood_vessel0.62353423
135MP0008438_abnormal_cutaneous_collagen0.62111335

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)4.44764030
2Elevated erythrocyte sedimentation rate (HP:0003565)4.34948905
3Recurrent abscess formation (HP:0002722)4.33439617
4Myositis (HP:0100614)4.27843927
5Milia (HP:0001056)3.81873787
6Thrombocytosis (HP:0001894)3.77692094
7Orchitis (HP:0100796)3.68929245
8Recurrent bacterial skin infections (HP:0005406)3.68825858
9Retrobulbar optic neuritis (HP:0100654)3.67718168
10Optic neuritis (HP:0100653)3.67718168
11Recurrent fungal infections (HP:0002841)3.64068641
12Right ventricular cardiomyopathy (HP:0011663)3.58596873
13Onycholysis (HP:0001806)3.56481354
14Autoimmune thrombocytopenia (HP:0001973)3.32991368
15Abnormality of T cell number (HP:0011839)3.14986302
16Increased IgM level (HP:0003496)3.09276954
17Plantar hyperkeratosis (HP:0007556)3.06933814
18Recurrent viral infections (HP:0004429)3.06272385
19Abnormality of macrophages (HP:0004311)3.05053046
20Alopecia of scalp (HP:0002293)3.04699153
21Abnormality of T cell physiology (HP:0011840)3.00029909
22Abnormality of T cells (HP:0002843)2.97858358
23Glucose intolerance (HP:0000833)2.93871141
24Abnormal delayed hypersensitivity skin test (HP:0002963)2.92464937
25Mediastinal lymphadenopathy (HP:0100721)2.91276309
26Stomatitis (HP:0010280)2.89104479
27T lymphocytopenia (HP:0005403)2.88887254
28Chronic otitis media (HP:0000389)2.86051868
29Reticulocytopenia (HP:0001896)2.81688384
30Chronic mucocutaneous candidiasis (HP:0002728)2.80676775
31Recurrent cutaneous fungal infections (HP:0011370)2.80676775
32Autoimmune hemolytic anemia (HP:0001890)2.79606789
33Obstructive lung disease (HP:0006536)2.78947806
34Chronic obstructive pulmonary disease (HP:0006510)2.78947806
35Vacuolated lymphocytes (HP:0001922)2.78197178
36Recurrent bronchitis (HP:0002837)2.75326179
37Vasculitis (HP:0002633)2.73550923
38Aortic dissection (HP:0002647)2.72972539
39Atrophic scars (HP:0001075)2.70432696
40Pustule (HP:0200039)2.69703626
41Fragile nails (HP:0001808)2.67415525
42IgM deficiency (HP:0002850)2.66516632
43Malnutrition (HP:0004395)2.63149540
44Lip pit (HP:0100267)2.62050971
45Recurrent skin infections (HP:0001581)2.61430357
46Chronic diarrhea (HP:0002028)2.60801751
47Interstitial pulmonary disease (HP:0006530)2.60566426
48Eosinophilia (HP:0001880)2.59951253
49Subacute progressive viral hepatitis (HP:0006572)2.55852486
50Spondylolisthesis (HP:0003302)2.55346598
51Leukocytosis (HP:0001974)2.53774029
52Periodontitis (HP:0000704)2.51404330
53Nasal polyposis (HP:0100582)2.51258212
54Hypoplasia of the uterus (HP:0000013)2.49092956
55IgA deficiency (HP:0002720)2.48501904
56Arterial thrombosis (HP:0004420)2.48175221
57Thick nail (HP:0001805)2.44991375
58Granulocytopenia (HP:0001913)2.43320912
59Hypergammaglobulinemia (HP:0010702)2.42238384
60IgG deficiency (HP:0004315)2.41673752
61Cheilitis (HP:0100825)2.40495172
62Meningitis (HP:0001287)2.40291987
63Palpitations (HP:0001962)2.40192028
64Gingivitis (HP:0000230)2.39526901
65Pulmonary infiltrates (HP:0002113)2.39442007
66Abnormality of eosinophils (HP:0001879)2.39106408
67Petechiae (HP:0000967)2.35201681
68Severe combined immunodeficiency (HP:0004430)2.34442642
69Palmoplantar hyperkeratosis (HP:0000972)2.32265854
70Nail dystrophy (HP:0008404)2.31603485
71Hemoptysis (HP:0002105)2.29723419
72Syringomyelia (HP:0003396)2.24434853
73Spinal cord lesions (HP:0100561)2.24434853
74Abnormality of cells of the lymphoid lineage (HP:0012140)2.23529807
75Aplastic anemia (HP:0001915)2.22157290
76Recurrent gram-negative bacterial infections (HP:0005420)2.20962905
77Panhypogammaglobulinemia (HP:0003139)2.16878317
78Encephalitis (HP:0002383)2.15882540
79Palmar hyperkeratosis (HP:0010765)2.15646280
80Micronodular cirrhosis (HP:0001413)2.15505215
81Abnormality of the nasal mucosa (HP:0000433)2.15116584
82Lymphopenia (HP:0001888)2.14979778
83Osteolytic defects of the phalanges of the hand (HP:0009771)2.14423941
84Osteolytic defects of the hand bones (HP:0009699)2.14423941
85Metaphyseal dysplasia (HP:0100255)2.13785895
86Basal ganglia calcification (HP:0002135)2.12611053
87Combined immunodeficiency (HP:0005387)2.11664512
88Cellulitis (HP:0100658)2.11554001
89Vertebral compression fractures (HP:0002953)2.09472485
90Thyroiditis (HP:0100646)2.08737801
91Hypoproteinemia (HP:0003075)2.07091443
92Sparse eyelashes (HP:0000653)2.06915624
93Inflammation of the large intestine (HP:0002037)2.06829268
94Gastrointestinal infarctions (HP:0005244)2.06578544
95Entropion (HP:0000621)2.05551332
96Premature rupture of membranes (HP:0001788)2.04041388
97Abnormality of B cell number (HP:0010975)2.03544865
98B lymphocytopenia (HP:0010976)2.03544865
9911 pairs of ribs (HP:0000878)2.02302971
100Abnormal pancreas size (HP:0012094)2.01926411
101Xerostomia (HP:0000217)2.01765591
102Keratoconjunctivitis sicca (HP:0001097)2.00564513
103Spontaneous hematomas (HP:0007420)1.99952429
104Gastrointestinal inflammation (HP:0004386)1.98121218
105Abnormal glucose tolerance (HP:0001952)1.97779749
106Curly hair (HP:0002212)1.96995381
107Abnormal hair laboratory examination (HP:0003328)1.95593229
108Increased IgE level (HP:0003212)1.95163327
109Abnormality of cells of the erythroid lineage (HP:0012130)1.94240401
110Pallor (HP:0000980)1.94086024
111Abnormality of oral frenula (HP:0000190)1.92345711
112Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.92178370
113Abnormality of nail color (HP:0100643)1.92053683
114Fatigue (HP:0012378)1.91134449
115Abnormal blistering of the skin (HP:0008066)1.91133896
116Arterial tortuosity (HP:0005116)1.89705028
117Prostate neoplasm (HP:0100787)1.89059860
118Recurrent pneumonia (HP:0006532)1.88459814
119Erythema (HP:0010783)1.88082560
120Keratoconjunctivitis (HP:0001096)1.87913756
121Osteomyelitis (HP:0002754)1.87832863
122Reduced subcutaneous adipose tissue (HP:0003758)1.86426435
123Woolly hair (HP:0002224)1.85898206
124Urticaria (HP:0001025)1.83684131
125Acute myeloid leukemia (HP:0004808)1.82767690
126Ectropion (HP:0000656)1.82722431
127Amaurosis fugax (HP:0100576)1.82563006
128Skin ulcer (HP:0200042)1.81550309
129Lymphoma (HP:0002665)1.81313483
130Poor head control (HP:0002421)1.80936384
131Abnormal albumin level (HP:0012116)1.80448132
132Hypoalbuminemia (HP:0003073)1.80448132
133Aortic aneurysm (HP:0004942)1.78964600
134Chest pain (HP:0100749)1.78402072
135Aplasia cutis congenita (HP:0001057)1.78265632
136Increased density of long bones (HP:0006392)1.76450325
137Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.76383971
138Oral leukoplakia (HP:0002745)1.76273433
139Peritonitis (HP:0002586)1.76178159
140Abnormality of the prostate (HP:0008775)1.76162704
141Abnormal number of erythroid precursors (HP:0012131)1.76091979
142Verrucae (HP:0200043)1.75902742
143Papilloma (HP:0012740)1.75902742
144Viral hepatitis (HP:0006562)1.75817387
145Absent frontal sinuses (HP:0002688)1.75810920
146Alveolar cell carcinoma (HP:0006519)1.75476944
147Abnormality of small intestinal villus morphology (HP:0011472)1.75401914
148Villous atrophy (HP:0011473)1.75401914
149Joint swelling (HP:0001386)1.75380553
150Type I transferrin isoform profile (HP:0003642)1.75113044
151Recurrent lower respiratory tract infections (HP:0002783)1.73968127
152Albinism (HP:0001022)1.73528090
153Fragile skin (HP:0001030)1.71083548

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K143.39941089
2JAK32.87643941
3PIM22.85003768
4MAP4K12.76174079
5TXK2.62893206
6BLK2.58323982
7NME22.45558261
8IRAK32.40434692
9TBK12.38913622
10TRIM282.26221946
11IRAK42.22778460
12IKBKB2.17608534
13MST42.12754880
14ZAP702.12434759
15STK241.96174695
16TYK21.95994590
17TESK11.91050914
18IKBKE1.89114662
19EPHA21.83627216
20TEC1.72126644
21CHUK1.64490469
22KIT1.63041608
23RPS6KA41.60377399
24BCR1.57968651
25MET1.55584528
26LATS11.54758489
27NLK1.53830900
28NEK91.53094645
29BTK1.48626908
30FLT31.43746413
31STK101.40134585
32STK38L1.36697183
33PIM11.35578779
34ITK1.34318966
35MAP3K21.30316497
36KDR1.28528009
37JAK11.28227284
38TESK21.27928301
39PBK1.27336468
40TGFBR11.24494503
41MAP3K31.23023803
42LRRK21.22104449
43ERBB31.19866651
44STK31.15716581
45PASK1.15377727
46EPHA31.15343784
47MAP2K31.13137295
48FRK1.09929027
49NUAK11.07460931
50LCK1.05856341
51SYK1.03004556
52TAOK31.02596001
53CSK1.01359353
54STK391.01067883
55TRPM71.01040625
56ERN10.96416384
57ACVR1B0.94483154
58FGFR40.92637611
59EIF2AK30.92034984
60PAK40.91971113
61PTK60.87931744
62HCK0.87914260
63FGFR30.87025689
64PDK20.83908696
65AKT30.83387428
66TTN0.82271928
67STK160.82110737
68LYN0.80574810
69BMPR20.79513845
70CSF1R0.79069277
71RPS6KB20.78734099
72PTK20.78590657
73PIK3CG0.78138862
74PRKCI0.77647856
75MELK0.77582180
76LMTK20.77439486
77STK40.76885506
78FER0.76541278
79EIF2AK20.74987061
80EEF2K0.72921541
81EPHB10.72204684
82IRAK10.71101177
83MAP3K110.68798803
84PRKCQ0.68691105
85TAF10.67045566
86TGFBR20.64310748
87EIF2AK10.63638606
88MAPKAPK20.63121993
89SCYL20.59812701
90ZAK0.59696110
91PRKG20.58697772
92OXSR10.58411011
93LIMK10.58410001
94MAP3K120.58394796
95MAP4K20.58208601
96SIK30.56699437
97MYLK0.56578461
98MST1R0.56227159
99STK380.55308239
100BMPR1B0.54216903
101TNIK0.53572127
102SRPK10.53267182
103ADRBK10.53150761
104MAP3K80.52940615
105MARK30.52618757
106PKN20.52070784
107MAP3K130.51842451
108MAP2K20.51814637
109BUB10.50603976
110ERBB40.49616782
111AURKB0.48658524
112DYRK1B0.48394453
113RIPK40.47804374
114GRK10.47060069
115PLK40.46772518
116ABL20.46288574
117DYRK30.45917350
118PIK3CA0.45694339
119JAK20.45128825
120RIPK10.44533196
121BRSK20.43657115
122DAPK10.43372776
123TLK10.43170513
124GRK60.43069744
125ABL10.42334752
126RPS6KA50.41724662
127CDK60.40965557
128ILK0.39697317
129MAP2K60.39182736
130KSR10.37990460
131ARAF0.36608493
132VRK20.36511179
133GRK70.33664010
134HIPK20.33090832
135EGFR0.32376871
136IGF1R0.30408876
137PTK2B0.29891690

Predicted pathways (KEGG)

RankGene SetZ-score
1Allograft rejection_Homo sapiens_hsa053302.81265176
2Graft-versus-host disease_Homo sapiens_hsa053322.60806250
3Intestinal immune network for IgA production_Homo sapiens_hsa046722.27978327
4NF-kappa B signaling pathway_Homo sapiens_hsa040642.26131937
5Leishmaniasis_Homo sapiens_hsa051402.25270078
6Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.18395328
7Primary immunodeficiency_Homo sapiens_hsa053402.18190502
8Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.12748482
9Measles_Homo sapiens_hsa051622.06425886
10Ribosome_Homo sapiens_hsa030102.05596703
11Antigen processing and presentation_Homo sapiens_hsa046121.86629392
12Legionellosis_Homo sapiens_hsa051341.81522525
13Proteasome_Homo sapiens_hsa030501.74516083
14RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.74178010
15Autoimmune thyroid disease_Homo sapiens_hsa053201.70902001
16Toll-like receptor signaling pathway_Homo sapiens_hsa046201.69062457
17Type I diabetes mellitus_Homo sapiens_hsa049401.67976145
18NOD-like receptor signaling pathway_Homo sapiens_hsa046211.67435328
19Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.61754148
20Hematopoietic cell lineage_Homo sapiens_hsa046401.59302815
21Shigellosis_Homo sapiens_hsa051311.55747101
22Herpes simplex infection_Homo sapiens_hsa051681.55055709
23Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.53540682
24Viral myocarditis_Homo sapiens_hsa054161.53123246
25Jak-STAT signaling pathway_Homo sapiens_hsa046301.52304854
26Osteoclast differentiation_Homo sapiens_hsa043801.51894471
27TNF signaling pathway_Homo sapiens_hsa046681.47275208
28Toxoplasmosis_Homo sapiens_hsa051451.44882968
29Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.40359230
30Asthma_Homo sapiens_hsa053101.37439083
31Influenza A_Homo sapiens_hsa051641.36441104
32Apoptosis_Homo sapiens_hsa042101.36148891
33Malaria_Homo sapiens_hsa051441.34907603
34Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.33495021
35p53 signaling pathway_Homo sapiens_hsa041151.32370866
36Protein export_Homo sapiens_hsa030601.29167258
37Pertussis_Homo sapiens_hsa051331.29085282
38DNA replication_Homo sapiens_hsa030301.25354570
39Leukocyte transendothelial migration_Homo sapiens_hsa046701.21192962
40Salmonella infection_Homo sapiens_hsa051321.17951777
41T cell receptor signaling pathway_Homo sapiens_hsa046601.17829361
42Hepatitis B_Homo sapiens_hsa051611.12017947
43Epstein-Barr virus infection_Homo sapiens_hsa051691.11650172
44Tuberculosis_Homo sapiens_hsa051521.10717578
45Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.10688728
46Rheumatoid arthritis_Homo sapiens_hsa053231.09716535
47B cell receptor signaling pathway_Homo sapiens_hsa046621.06083350
48Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.05803085
49Other glycan degradation_Homo sapiens_hsa005111.02133141
50Small cell lung cancer_Homo sapiens_hsa052220.97250069
51ECM-receptor interaction_Homo sapiens_hsa045120.96505373
52Sulfur metabolism_Homo sapiens_hsa009200.96264388
53Viral carcinogenesis_Homo sapiens_hsa052030.94359397
54Chemokine signaling pathway_Homo sapiens_hsa040620.93130452
55Chronic myeloid leukemia_Homo sapiens_hsa052200.92459087
56Transcriptional misregulation in cancer_Homo sapiens_hsa052020.91550170
57Acute myeloid leukemia_Homo sapiens_hsa052210.90986576
58Mismatch repair_Homo sapiens_hsa034300.90827544
59AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.88964451
60Base excision repair_Homo sapiens_hsa034100.88160072
61HTLV-I infection_Homo sapiens_hsa051660.87973425
62Homologous recombination_Homo sapiens_hsa034400.85773705
63Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.85664618
64Spliceosome_Homo sapiens_hsa030400.82095687
65Hepatitis C_Homo sapiens_hsa051600.81657293
66Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.81444181
67Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.81152110
68Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.80285384
69Prolactin signaling pathway_Homo sapiens_hsa049170.75740111
70Cell cycle_Homo sapiens_hsa041100.74014032
71Pancreatic cancer_Homo sapiens_hsa052120.73400869
72Pyrimidine metabolism_Homo sapiens_hsa002400.73267026
73Phagosome_Homo sapiens_hsa041450.72399011
74RNA polymerase_Homo sapiens_hsa030200.71789250
75Caffeine metabolism_Homo sapiens_hsa002320.70145502
76Lysosome_Homo sapiens_hsa041420.69617117
77Nucleotide excision repair_Homo sapiens_hsa034200.66194345
78Renal cell carcinoma_Homo sapiens_hsa052110.66125058
79Drug metabolism - other enzymes_Homo sapiens_hsa009830.62722036
80Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.62257243
81RNA transport_Homo sapiens_hsa030130.62171066
82Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.61196253
83MicroRNAs in cancer_Homo sapiens_hsa052060.61155661
84Adherens junction_Homo sapiens_hsa045200.61120508
85Platelet activation_Homo sapiens_hsa046110.60731819
86Non-homologous end-joining_Homo sapiens_hsa034500.59565137
87Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.58817834
88Endocytosis_Homo sapiens_hsa041440.58747057
89Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.56619941
90Non-small cell lung cancer_Homo sapiens_hsa052230.56376547
91Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.55876759
92African trypanosomiasis_Homo sapiens_hsa051430.55793209
93Fanconi anemia pathway_Homo sapiens_hsa034600.53952790
94Sphingolipid metabolism_Homo sapiens_hsa006000.53341148
95Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.53147137
96Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.52017511
97Thyroid cancer_Homo sapiens_hsa052160.51185043
98SNARE interactions in vesicular transport_Homo sapiens_hsa041300.51042885
99RNA degradation_Homo sapiens_hsa030180.50040419
100Galactose metabolism_Homo sapiens_hsa000520.49661466
101Glutathione metabolism_Homo sapiens_hsa004800.49552855
102Glycosaminoglycan degradation_Homo sapiens_hsa005310.49287947
103Renin-angiotensin system_Homo sapiens_hsa046140.48820149
104N-Glycan biosynthesis_Homo sapiens_hsa005100.48541541
105FoxO signaling pathway_Homo sapiens_hsa040680.47778018
106Proteoglycans in cancer_Homo sapiens_hsa052050.46708645
107Nitrogen metabolism_Homo sapiens_hsa009100.45923147
108Regulation of actin cytoskeleton_Homo sapiens_hsa048100.44717964
109Amoebiasis_Homo sapiens_hsa051460.44152257
110Pathways in cancer_Homo sapiens_hsa052000.43724049
111Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.43479060
112Pentose and glucuronate interconversions_Homo sapiens_hsa000400.43105811
113One carbon pool by folate_Homo sapiens_hsa006700.42709311
114Prostate cancer_Homo sapiens_hsa052150.41686396
115Inositol phosphate metabolism_Homo sapiens_hsa005620.41432155
116HIF-1 signaling pathway_Homo sapiens_hsa040660.40881279
117TGF-beta signaling pathway_Homo sapiens_hsa043500.40793156
118Systemic lupus erythematosus_Homo sapiens_hsa053220.40282713
119Focal adhesion_Homo sapiens_hsa045100.40241687
120Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.39709999
121Basal transcription factors_Homo sapiens_hsa030220.39056600
122Staphylococcus aureus infection_Homo sapiens_hsa051500.39045186
123Bladder cancer_Homo sapiens_hsa052190.38248717
124Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.37933018

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