TERF2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a telomere specific protein, TERF2, which is a component of the telomere nucleoprotein complex. This protein is present at telomeres in metaphase of the cell cycle, is a second negative regulator of telomere length and plays a key role in the protective activity of telomeres. While having similar telomere binding activity and domain organization, TERF2 differs from TERF1 in that its N terminus is basic rather than acidic. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1L-fucose catabolic process (GO:0042355)4.90838303
2fucose catabolic process (GO:0019317)4.90838303
3L-fucose metabolic process (GO:0042354)4.90838303
4behavioral response to nicotine (GO:0035095)4.82711853
5DNA unwinding involved in DNA replication (GO:0006268)4.27472181
6pre-miRNA processing (GO:0031054)4.21086768
7mitotic sister chromatid cohesion (GO:0007064)4.16230937
8protein localization to kinetochore (GO:0034501)4.06287042
9DNA deamination (GO:0045006)3.95581564
10negative regulation of histone methylation (GO:0031061)3.89512181
11negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.76002995
12ribosomal small subunit assembly (GO:0000028)3.75195959
13negative regulation of RNA splicing (GO:0033119)3.68868479
14response to pheromone (GO:0019236)3.63027546
15regulation of meiosis I (GO:0060631)3.59467871
16cellular ketone body metabolic process (GO:0046950)3.55284868
17positive regulation of cell cycle G2/M phase transition (GO:1902751)3.47015090
18positive regulation of G2/M transition of mitotic cell cycle (GO:0010971)3.47015090
19DNA topological change (GO:0006265)3.46268946
20regulation of RNA export from nucleus (GO:0046831)3.46130356
21negative regulation of mRNA metabolic process (GO:1903312)3.44269253
22positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.42123829
23positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.42123829
24positive regulation of mitotic sister chromatid separation (GO:1901970)3.42123829
25piRNA metabolic process (GO:0034587)3.40833661
26negative regulation of mRNA processing (GO:0050686)3.40000767
27histone H4-K12 acetylation (GO:0043983)3.39631008
28regulation of histone H3-K9 methylation (GO:0051570)3.36490687
29heterochromatin organization (GO:0070828)3.35664151
30protein localization to chromosome, centromeric region (GO:0071459)3.30383033
31positive regulation of meiosis (GO:0045836)3.28916461
32regulation of sister chromatid cohesion (GO:0007063)3.26914203
33sister chromatid segregation (GO:0000819)3.23624973
34regulation of DNA endoreduplication (GO:0032875)3.23300603
35meiotic chromosome segregation (GO:0045132)3.21405822
36kinetochore organization (GO:0051383)3.20909796
37detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.20272127
38regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.18611038
39positive regulation of histone deacetylation (GO:0031065)3.18243939
40regulation of histone H3-K4 methylation (GO:0051569)3.17880082
41regulation of hexokinase activity (GO:1903299)3.13955316
42regulation of glucokinase activity (GO:0033131)3.13955316
43ketone body metabolic process (GO:1902224)3.10877548
44attachment of spindle microtubules to kinetochore (GO:0008608)3.10468267
45peptidyl-lysine trimethylation (GO:0018023)3.10408546
46definitive hemopoiesis (GO:0060216)3.10201628
47platelet dense granule organization (GO:0060155)3.09468086
48respiratory chain complex IV assembly (GO:0008535)3.08785006
49water-soluble vitamin biosynthetic process (GO:0042364)3.07415752
50mitotic chromosome condensation (GO:0007076)3.06779216
51positive regulation of chromosome segregation (GO:0051984)3.06392413
52maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.05839030
53synapsis (GO:0007129)3.00151631
54chromatin assembly (GO:0031497)2.99532305
55positive regulation of meiotic cell cycle (GO:0051446)2.99276068
56DNA methylation involved in gamete generation (GO:0043046)2.98334424
57protein K6-linked ubiquitination (GO:0085020)2.96851940
58positive regulation of histone H3-K4 methylation (GO:0051571)2.95742950
59histone H3-K4 methylation (GO:0051568)2.95398705
60inositol phosphate catabolic process (GO:0071545)2.95323022
61mitotic sister chromatid segregation (GO:0000070)2.94529337
62startle response (GO:0001964)2.94467116
63histone H3-K4 trimethylation (GO:0080182)2.93905503
64glucocorticoid receptor signaling pathway (GO:0042921)2.93230839
65negative regulation of cell killing (GO:0031342)2.93041675
66negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.93041675
67embryonic process involved in female pregnancy (GO:0060136)2.92998251
68alternative mRNA splicing, via spliceosome (GO:0000380)2.92123907
69reciprocal meiotic recombination (GO:0007131)2.87555128
70reciprocal DNA recombination (GO:0035825)2.87555128
71RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.87174350
72protein-DNA complex disassembly (GO:0032986)2.85902957
73nucleosome disassembly (GO:0006337)2.85902957
74V(D)J recombination (GO:0033151)2.85106052
75kidney morphogenesis (GO:0060993)2.84600796
76DNA geometric change (GO:0032392)2.82417731
77peptidyl-lysine dimethylation (GO:0018027)2.81273404
78NLS-bearing protein import into nucleus (GO:0006607)2.81022421
79nuclear pore organization (GO:0006999)2.80833547
80replication fork processing (GO:0031297)2.80512153
81histone lysine methylation (GO:0034968)2.80508650
82DNA duplex unwinding (GO:0032508)2.79214083
83DNA double-strand break processing (GO:0000729)2.78745025
84mRNA splice site selection (GO:0006376)2.78438225
85cytochrome complex assembly (GO:0017004)2.77672428
86mitotic nuclear envelope disassembly (GO:0007077)2.77584634
87regulation of histone methylation (GO:0031060)2.77058505
88viral transcription (GO:0019083)2.75910719
89regulation of nucleobase-containing compound transport (GO:0032239)2.75371868
90auditory receptor cell stereocilium organization (GO:0060088)2.73774572
91double-strand break repair via homologous recombination (GO:0000724)2.73611117
92negative regulation of gene expression, epigenetic (GO:0045814)2.73010493
93membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.72898324
94recombinational repair (GO:0000725)2.71406534
95negative regulation of reactive oxygen species metabolic process (GO:2000378)2.71066325
96histone methylation (GO:0016571)2.70282526
97protein complex biogenesis (GO:0070271)2.69738210
98positive regulation by host of viral transcription (GO:0043923)2.65072094
99primary amino compound metabolic process (GO:1901160)2.64845645
100preassembly of GPI anchor in ER membrane (GO:0016254)2.64196884
101dopamine transport (GO:0015872)2.64005063
102translational termination (GO:0006415)2.63240461
103regulation of neurotransmitter uptake (GO:0051580)2.63036905
104megakaryocyte development (GO:0035855)2.62820602
105nuclear envelope disassembly (GO:0051081)2.62809503
106membrane disassembly (GO:0030397)2.62809503
107neuronal action potential (GO:0019228)2.62689590
108regulation of mitotic spindle organization (GO:0060236)2.62616283
109mitochondrial respiratory chain complex assembly (GO:0033108)2.62339846
110phosphorylated carbohydrate dephosphorylation (GO:0046838)2.62157068
111inositol phosphate dephosphorylation (GO:0046855)2.62157068
112peptidyl-lysine methylation (GO:0018022)2.61559678
113regulation of rhodopsin mediated signaling pathway (GO:0022400)2.60707893
114positive regulation of gene expression, epigenetic (GO:0045815)2.60458960
115protein import into peroxisome matrix (GO:0016558)2.59973166
116positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.59952105
117dendritic spine morphogenesis (GO:0060997)2.58927862
118rhodopsin mediated signaling pathway (GO:0016056)2.58091473
119maturation of SSU-rRNA (GO:0030490)2.57984444
120RNA stabilization (GO:0043489)2.57738144
121mRNA stabilization (GO:0048255)2.57738144
122histone H2A monoubiquitination (GO:0035518)2.57092600
123negative regulation of histone modification (GO:0031057)2.56808561
124kynurenine metabolic process (GO:0070189)2.56692320
125polyol catabolic process (GO:0046174)2.56308423
126presynaptic membrane assembly (GO:0097105)2.56034684
127base-excision repair (GO:0006284)2.54379547
128kinetochore assembly (GO:0051382)2.54202516
129intracellular estrogen receptor signaling pathway (GO:0030520)2.53665117
130regulation of spindle organization (GO:0090224)2.53502762
131proline transport (GO:0015824)2.51891155
132nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.51850679
133* negative regulation of DNA-dependent DNA replication (GO:2000104)2.51631418
134presynaptic membrane organization (GO:0097090)2.51169346
135somite development (GO:0061053)2.50096963
136DNA strand elongation (GO:0022616)2.49648922
137regulation of protein glycosylation (GO:0060049)2.49633963
138mitochondrial respiratory chain complex I assembly (GO:0032981)2.49479414
139NADH dehydrogenase complex assembly (GO:0010257)2.49479414
140mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.49479414
141rRNA catabolic process (GO:0016075)2.48703160
142protein localization to cilium (GO:0061512)2.48578237
143reflex (GO:0060004)2.48161571
144chromatin silencing (GO:0006342)2.48079041
145formation of translation preinitiation complex (GO:0001731)2.47823421
146DNA strand elongation involved in DNA replication (GO:0006271)2.47732010
147mitotic metaphase plate congression (GO:0007080)2.47494993
148detection of light stimulus involved in visual perception (GO:0050908)2.47264138
149detection of light stimulus involved in sensory perception (GO:0050962)2.47264138
150DNA conformation change (GO:0071103)2.47177724
151genetic imprinting (GO:0071514)2.47138269
152histone H4-K16 acetylation (GO:0043984)2.46882765
153positive regulation of histone methylation (GO:0031062)2.46684576
154positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.46661074
155somatic diversification of immune receptors via somatic mutation (GO:0002566)2.46611968
156somatic hypermutation of immunoglobulin genes (GO:0016446)2.46611968
157gamma-aminobutyric acid transport (GO:0015812)2.46544578
158glycerophospholipid catabolic process (GO:0046475)2.46454110
159serotonin metabolic process (GO:0042428)2.46286144
160positive regulation of sodium ion transmembrane transport (GO:1902307)2.46220427
161regulation of translational fidelity (GO:0006450)2.46189686
162nonmotile primary cilium assembly (GO:0035058)2.45997500
163negative regulation of translation, ncRNA-mediated (GO:0040033)2.45839174
164regulation of translation, ncRNA-mediated (GO:0045974)2.45839174
165negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.45839174
166adaptation of signaling pathway (GO:0023058)2.45823787
167regulation of stem cell maintenance (GO:2000036)2.44465912
168G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.44360990
169negative regulation of synaptic transmission, GABAergic (GO:0032229)2.43965086
170regulation of action potential (GO:0098900)2.43509380
171nuclear pore complex assembly (GO:0051292)2.42402323
172protein polyglutamylation (GO:0018095)2.41923970
173regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.41563179
174histone H2A acetylation (GO:0043968)2.41240591
175chromatin assembly or disassembly (GO:0006333)2.41130219
176behavioral response to ethanol (GO:0048149)2.40975402
177* protein localization to chromosome (GO:0034502)2.40744533
178phosphatidylinositol acyl-chain remodeling (GO:0036149)2.40720887
179DNA strand renaturation (GO:0000733)2.39355203
180regulation of calcium ion-dependent exocytosis (GO:0017158)2.39256273
181indole-containing compound catabolic process (GO:0042436)2.38342658
182indolalkylamine catabolic process (GO:0046218)2.38342658
183tryptophan catabolic process (GO:0006569)2.38342658
184retinal cone cell development (GO:0046549)2.38110143
185multicellular organism reproduction (GO:0032504)2.37999046
186axoneme assembly (GO:0035082)2.37754867
187membrane depolarization during action potential (GO:0086010)2.37035759
188protein K11-linked deubiquitination (GO:0035871)2.36145365
189C4-dicarboxylate transport (GO:0015740)2.35951837
190indolalkylamine metabolic process (GO:0006586)2.35923690
191inner ear receptor stereocilium organization (GO:0060122)2.35417780
192negative regulation of cytosolic calcium ion concentration (GO:0051481)2.33769110

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.86968101
2FOXM1_23109430_ChIP-Seq_U2OS_Human5.28869182
3MYC_22102868_ChIP-Seq_BL_Human4.00904883
4EGR1_19374776_ChIP-ChIP_THP-1_Human3.96818429
5ZNF274_21170338_ChIP-Seq_K562_Hela3.91061873
6E2F4_17652178_ChIP-ChIP_JURKAT_Human3.43441949
7VDR_22108803_ChIP-Seq_LS180_Human3.29656356
8GBX2_23144817_ChIP-Seq_PC3_Human2.93657106
9GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.77588512
10GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.72354995
11FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.71692448
12TP63_19390658_ChIP-ChIP_HaCaT_Human2.70785211
13ZFP57_27257070_Chip-Seq_ESCs_Mouse2.66477444
14VDR_21846776_ChIP-Seq_THP-1_Human2.64186927
15EZH2_22144423_ChIP-Seq_EOC_Human2.49197082
16STAT6_21828071_ChIP-Seq_BEAS2B_Human2.46315215
17IGF1R_20145208_ChIP-Seq_DFB_Human2.45284167
18POU3F2_20337985_ChIP-ChIP_501MEL_Human2.36525970
19FLI1_27457419_Chip-Seq_LIVER_Mouse2.31041596
20E2F1_21310950_ChIP-Seq_MCF-7_Human2.29694424
21MYC_18555785_ChIP-Seq_MESCs_Mouse2.29540236
22TCF7_22412390_ChIP-Seq_EML_Mouse2.27220825
23SCL_19346495_ChIP-Seq_HPC-7_Human2.19936287
24* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.15782448
25CIITA_25753668_ChIP-Seq_RAJI_Human2.14322227
26* MYC_19079543_ChIP-ChIP_MESCs_Mouse2.08128281
27RBPJ_22232070_ChIP-Seq_NCS_Mouse2.06886974
28CTBP2_25329375_ChIP-Seq_LNCAP_Human2.03383874
29KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.99902415
30P300_19829295_ChIP-Seq_ESCs_Human1.99391593
31CTBP1_25329375_ChIP-Seq_LNCAP_Human1.98188199
32HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.95637898
33KDM2B_26808549_Chip-Seq_DND41_Human1.92983271
34EST1_17652178_ChIP-ChIP_JURKAT_Human1.90473286
35* CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.88454570
36NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.87277895
37NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.84038595
38PCGF2_27294783_Chip-Seq_ESCs_Mouse1.81533816
39PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.78241830
40* ER_23166858_ChIP-Seq_MCF-7_Human1.77691977
41KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.77509554
42SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.75352220
43TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.73948745
44HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.73077662
45STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.72422967
46BCAT_22108803_ChIP-Seq_LS180_Human1.67399271
47EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.67296985
48KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.66626423
49SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.65740126
50UTX_26944678_Chip-Seq_JUKART_Human1.63574818
51ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.59508596
52TAF15_26573619_Chip-Seq_HEK293_Human1.58045951
53GABP_17652178_ChIP-ChIP_JURKAT_Human1.57619365
54AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.57198374
55TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.55117934
56STAT3_23295773_ChIP-Seq_U87_Human1.54815623
57PKCTHETA_26484144_Chip-Seq_BREAST_Human1.54260161
58ZFP281_27345836_Chip-Seq_ESCs_Mouse1.53681556
59SALL1_21062744_ChIP-ChIP_HESCs_Human1.53325860
60REST_21632747_ChIP-Seq_MESCs_Mouse1.52476744
61TCF4_23295773_ChIP-Seq_U87_Human1.51893496
62* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.51538382
63UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.50418285
64RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.48056651
65ESR1_15608294_ChIP-ChIP_MCF-7_Human1.47605751
66POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.47482773
67TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.47482773
68MAF_26560356_Chip-Seq_TH1_Human1.46830468
69MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.46619695
70KDM2B_26808549_Chip-Seq_JURKAT_Human1.46028377
71AR_25329375_ChIP-Seq_VCAP_Human1.45994985
72SMAD4_21799915_ChIP-Seq_A2780_Human1.45386638
73VDR_24763502_ChIP-Seq_THP-1_Human1.44933288
74NANOG_19829295_ChIP-Seq_ESCs_Human1.44448192
75SOX2_19829295_ChIP-Seq_ESCs_Human1.44448192
76ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.44374945
77TP53_22573176_ChIP-Seq_HFKS_Human1.43893912
78IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.42159654
79CBP_20019798_ChIP-Seq_JUKART_Human1.42159654
80MYC_18940864_ChIP-ChIP_HL60_Human1.42004115
81EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.41307769
82KDM2B_26808549_Chip-Seq_SUP-B15_Human1.40961661
83PCGF2_27294783_Chip-Seq_NPCs_Mouse1.39547355
84BMI1_23680149_ChIP-Seq_NPCS_Mouse1.38713028
85* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.38689492
86DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.38144903
87MYB_26560356_Chip-Seq_TH2_Human1.37756233
88DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.37311651
89TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.36268826
90FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.35740962
91RNF2_27304074_Chip-Seq_NSC_Mouse1.34799663
92MYB_26560356_Chip-Seq_TH1_Human1.33693333
93KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.33599211
94KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.33599211
95KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.33599211
96MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.33577626
97TCF4_22108803_ChIP-Seq_LS180_Human1.32958362
98MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.32647462
99MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.32339037
100SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.32166728
101YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.32034635
102MYCN_18555785_ChIP-Seq_MESCs_Mouse1.31497649
103TTF2_22483619_ChIP-Seq_HELA_Human1.30369518
104E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.28386112
105XRN2_22483619_ChIP-Seq_HELA_Human1.27554054
106FLI1_21867929_ChIP-Seq_TH2_Mouse1.27473474
107HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.27345863
108CBX2_27304074_Chip-Seq_ESCs_Mouse1.27111812
109IRF1_19129219_ChIP-ChIP_H3396_Human1.26385429
110SUZ12_27294783_Chip-Seq_NPCs_Mouse1.26152914
111SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.25509478
112PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.25242344
113PRDM14_20953172_ChIP-Seq_ESCs_Human1.25151066
114* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.24796628
115ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.24786184
116MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.24026171
117EZH2_27294783_Chip-Seq_NPCs_Mouse1.22669512
118NR3C1_21868756_ChIP-Seq_MCF10A_Human1.22211793
119NANOG_21062744_ChIP-ChIP_HESCs_Human1.22034466
120SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.21563532
121TOP2B_26459242_ChIP-Seq_MCF-7_Human1.20955969
122PIAS1_25552417_ChIP-Seq_VCAP_Human1.20946540
123NFE2_27457419_Chip-Seq_LIVER_Mouse1.20883410
124POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.20734881
125TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.20117457
126AR_21572438_ChIP-Seq_LNCaP_Human1.19625411
127EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.18604419
128GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.18474334
129BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.18240773
130EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.17774831
131ELK1_19687146_ChIP-ChIP_HELA_Human1.16899034
132CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.16106267
133AR_21909140_ChIP-Seq_LNCAP_Human1.15641363
134FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.14146604
135SMAD3_21741376_ChIP-Seq_EPCs_Human1.13948495
136KLF5_20875108_ChIP-Seq_MESCs_Mouse1.13770014
137FOXA1_25329375_ChIP-Seq_VCAP_Human1.13208651
138FOXA1_27270436_Chip-Seq_PROSTATE_Human1.13208651
139KDM5A_27292631_Chip-Seq_BREAST_Human1.12629269
140OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.12162235
141SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.11863279
142HOXB7_26014856_ChIP-Seq_BT474_Human1.10289195
143NCOR_22424771_ChIP-Seq_293T_Human1.10193907
144CDX2_22108803_ChIP-Seq_LS180_Human1.10104357
145SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.10074235
146NANOG_18555785_Chip-Seq_ESCs_Mouse1.09821004
147TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.09368642
148ETV2_25802403_ChIP-Seq_MESCs_Mouse1.08919408
149CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.08849353
150MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.08779987
151CRX_20693478_ChIP-Seq_RETINA_Mouse1.08304623
152TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.05622771
153SPI1_23127762_ChIP-Seq_K562_Human1.05574012
154TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.05184314
155SMAD4_21741376_ChIP-Seq_EPCs_Human1.04970242
156FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.04867027
157GATA3_21878914_ChIP-Seq_MCF-7_Human1.04726004
158EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.04506107
159HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.04122672
160RUNX2_22187159_ChIP-Seq_PCA_Human1.03522633
161P53_22387025_ChIP-Seq_ESCs_Mouse1.02456226
162REST_18959480_ChIP-ChIP_MESCs_Mouse1.02067603
163* FOXA1_21572438_ChIP-Seq_LNCaP_Human1.01769384
164GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.01632125
165WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.99877359
166* CHD1_26751641_Chip-Seq_LNCaP_Human0.99697486
167MAF_26560356_Chip-Seq_TH2_Human0.99661508
168ZFP281_18757296_ChIP-ChIP_E14_Mouse0.99314401
169E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.98768746
170SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.97464872
171NCOR1_26117541_ChIP-Seq_K562_Human0.97445450
172CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.96876829
173EWS_26573619_Chip-Seq_HEK293_Human0.96610771
174SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.95280376
175SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.95208975
176SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.93970150
177TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.93077829
178VDR_23849224_ChIP-Seq_CD4+_Human0.92985143
179SOX2_18555785_ChIP-Seq_MESCs_Mouse0.92857623
180FOXP3_21729870_ChIP-Seq_TREG_Human0.91546180
181NOTCH1_21737748_ChIP-Seq_TLL_Human0.91309571
182MYC_18358816_ChIP-ChIP_MESCs_Mouse0.89970536
183ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.89345535
184FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.89246689
185PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.89013020
186* THAP11_20581084_ChIP-Seq_MESCs_Mouse0.88777819
187NFIB_24661679_ChIP-Seq_LUNG_Mouse0.87254281
188* ZFX_18555785_ChIP-Seq_MESCs_Mouse0.86991885
189KLF4_18555785_ChIP-Seq_MESCs_Mouse0.86177951
190FUS_26573619_Chip-Seq_HEK293_Human0.85454095
191RUNX1_22412390_ChIP-Seq_EML_Mouse0.85116810

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication4.52387017
2MP0003283_abnormal_digestive_organ3.55763628
3MP0010094_abnormal_chromosome_stability3.19972554
4MP0008877_abnormal_DNA_methylation3.11396196
5MP0002102_abnormal_ear_morphology2.85752040
6MP0002837_dystrophic_cardiac_calcinosis2.81803325
7MP0002396_abnormal_hematopoietic_system2.77686366
8MP0003123_paternal_imprinting2.71981048
9* MP0003111_abnormal_nucleus_morphology2.69012587
10MP0003195_calcinosis2.68600975
11MP0004808_abnormal_hematopoietic_stem2.67041464
12MP0005076_abnormal_cell_differentiation2.63301244
13MP0003121_genomic_imprinting2.42943998
14MP0009278_abnormal_bone_marrow2.34764796
15MP0003787_abnormal_imprinting2.34497146
16MP0001968_abnormal_touch/_nociception2.28347685
17MP0009046_muscle_twitch2.28292388
18MP0009745_abnormal_behavioral_response2.26000833
19MP0003077_abnormal_cell_cycle2.22474071
20MP0004043_abnormal_pH_regulation2.13898542
21MP0003880_abnormal_central_pattern2.06527481
22MP0004885_abnormal_endolymph2.04012132
23MP0003646_muscle_fatigue2.03569001
24MP0004957_abnormal_blastocyst_morpholog2.00342001
25MP0005551_abnormal_eye_electrophysiolog1.98717483
26MP0003693_abnormal_embryo_hatching1.97964008
27MP0002272_abnormal_nervous_system1.93129038
28MP0010352_gastrointestinal_tract_polyps1.92171168
29MP0003122_maternal_imprinting1.88751825
30MP0001486_abnormal_startle_reflex1.81863287
31MP0002064_seizures1.81844568
32MP0002736_abnormal_nociception_after1.80366964
33MP0000490_abnormal_crypts_of1.76309540
34MP0004147_increased_porphyrin_level1.73723668
35MP0005174_abnormal_tail_pigmentation1.71910134
36MP0001986_abnormal_taste_sensitivity1.67834678
37MP0000703_abnormal_thymus_morphology1.67832928
38MP0003763_abnormal_thymus_physiology1.67318342
39MP0008872_abnormal_physiological_respon1.66470224
40MP0003635_abnormal_synaptic_transmissio1.65721484
41MP0000516_abnormal_urinary_system1.65574660
42MP0005367_renal/urinary_system_phenotyp1.65574660
43MP0002877_abnormal_melanocyte_morpholog1.65350836
44MP0001545_abnormal_hematopoietic_system1.65007048
45MP0005397_hematopoietic_system_phenotyp1.65007048
46MP0002163_abnormal_gland_morphology1.64519130
47MP0005645_abnormal_hypothalamus_physiol1.62304947
48MP0002653_abnormal_ependyma_morphology1.62083724
49MP0004142_abnormal_muscle_tone1.61938912
50MP0002876_abnormal_thyroid_physiology1.61879688
51MP0002938_white_spotting1.58506686
52MP0001501_abnormal_sleep_pattern1.53676774
53MP0004742_abnormal_vestibular_system1.52223548
54MP0005646_abnormal_pituitary_gland1.49720505
55MP0002084_abnormal_developmental_patter1.48270076
56MP0000427_abnormal_hair_cycle1.48046420
57MP0008007_abnormal_cellular_replicative1.46522484
58MP0000350_abnormal_cell_proliferation1.45486276
59MP0006054_spinal_hemorrhage1.45474375
60MP0004197_abnormal_fetal_growth/weight/1.43325474
61MP0002009_preneoplasia1.42357140
62MP0002398_abnormal_bone_marrow1.40242381
63MP0002063_abnormal_learning/memory/cond1.40191821
64MP0002572_abnormal_emotion/affect_behav1.40069686
65MP0002751_abnormal_autonomic_nervous1.40021951
66MP0001697_abnormal_embryo_size1.38038638
67MP0008058_abnormal_DNA_repair1.37919042
68MP0005253_abnormal_eye_physiology1.35964440
69MP0002557_abnormal_social/conspecific_i1.35258100
70MP0004233_abnormal_muscle_weight1.33692799
71MP0004859_abnormal_synaptic_plasticity1.33314386
72MP0002735_abnormal_chemical_nociception1.32787029
73MP0006276_abnormal_autonomic_nervous1.32153452
74MP0002638_abnormal_pupillary_reflex1.30362341
75MP0004924_abnormal_behavior1.28788829
76MP0005386_behavior/neurological_phenoty1.28788829
77MP0004145_abnormal_muscle_electrophysio1.28395700
78MP0002234_abnormal_pharynx_morphology1.27563178
79MP0003890_abnormal_embryonic-extraembry1.27291819
80MP0002085_abnormal_embryonic_tissue1.26206354
81MP0001730_embryonic_growth_arrest1.25982514
82MP0003119_abnormal_digestive_system1.25815144
83MP0000631_abnormal_neuroendocrine_gland1.24953256
84MP0001984_abnormal_olfaction1.24940352
85MP0002928_abnormal_bile_duct1.24023698
86MP0002086_abnormal_extraembryonic_tissu1.23556644
87MP0002160_abnormal_reproductive_system1.23108576
88MP0008961_abnormal_basal_metabolism1.22177623
89MP0005084_abnormal_gallbladder_morpholo1.21201162
90MP0001485_abnormal_pinna_reflex1.19897404
91MP0001672_abnormal_embryogenesis/_devel1.19052129
92MP0005380_embryogenesis_phenotype1.19052129
93MP0002733_abnormal_thermal_nociception1.18407487
94MP0002166_altered_tumor_susceptibility1.17794391
95MP0001970_abnormal_pain_threshold1.16379380
96MP0000569_abnormal_digit_pigmentation1.16105115
97MP0001529_abnormal_vocalization1.15319864
98MP0001905_abnormal_dopamine_level1.14635234
99MP0009703_decreased_birth_body1.13598942
100MP0006292_abnormal_olfactory_placode1.13381307
101MP0002019_abnormal_tumor_incidence1.13138536
102MP0010307_abnormal_tumor_latency1.11109004
103MP0002067_abnormal_sensory_capabilities1.10947478
104MP0002138_abnormal_hepatobiliary_system1.10153255
105MP0003567_abnormal_fetal_cardiomyocyte1.08912611
106MP0005389_reproductive_system_phenotype1.08460896
107* MP0002080_prenatal_lethality1.08230282
108MP0003984_embryonic_growth_retardation1.07834739
109MP0009672_abnormal_birth_weight1.07820334
110MP0003136_yellow_coat_color1.07199073
111MP0000015_abnormal_ear_pigmentation1.06822783
112MP0002088_abnormal_embryonic_growth/wei1.05415816
113MP0005623_abnormal_meninges_morphology1.04890350
114MP0003300_gastrointestinal_ulcer1.03968371
115MP0006072_abnormal_retinal_apoptosis1.03886500
116MP0002722_abnormal_immune_system1.02342677
117MP0003718_maternal_effect1.02298317
118MP0002734_abnormal_mechanical_nocicepti1.02145004
119MP0004215_abnormal_myocardial_fiber1.01412895
120MP0000313_abnormal_cell_death1.00615548
121MP0005220_abnormal_exocrine_pancreas0.99641181
122MP0002184_abnormal_innervation0.98332963
123MP0001502_abnormal_circadian_rhythm0.96729995
124MP0000372_irregular_coat_pigmentation0.96443644
125MP0008770_decreased_survivor_rate0.95740245
126MP0010234_abnormal_vibrissa_follicle0.95009847
127MP0002006_tumorigenesis0.94048595
128MP0000613_abnormal_salivary_gland0.93016340
129MP0000003_abnormal_adipose_tissue0.91741273
130MP0003935_abnormal_craniofacial_develop0.90797529
131MP0003045_fibrosis0.90469548
132MP0000778_abnormal_nervous_system0.89951465
133MP0000689_abnormal_spleen_morphology0.89644150
134MP0002095_abnormal_skin_pigmentation0.89451721
135MP0001919_abnormal_reproductive_system0.85733221
136MP0003861_abnormal_nervous_system0.85717266
137MP0000716_abnormal_immune_system0.85344414
138MP0008932_abnormal_embryonic_tissue0.83958646
139MP0009333_abnormal_splenocyte_physiolog0.83460554
140MP0003698_abnormal_male_reproductive0.83290413
141MP0005379_endocrine/exocrine_gland_phen0.83092701
142MP0002925_abnormal_cardiovascular_devel0.82708868
143MP0003866_abnormal_defecation0.82485071
144MP0002429_abnormal_blood_cell0.81919871
145MP0002752_abnormal_somatic_nervous0.81846309
146MP0000733_abnormal_muscle_development0.78847254
147MP0001440_abnormal_grooming_behavior0.78773028
148MP0001800_abnormal_humoral_immune0.77813733
149MP0001188_hyperpigmentation0.77256544
150MP0003942_abnormal_urinary_system0.77046619
151MP0005409_darkened_coat_color0.76733458
152MP0009780_abnormal_chondrocyte_physiolo0.76005339
153MP0005248_abnormal_Harderian_gland0.75938478
154MP0002882_abnormal_neuron_morphology0.74635557
155MP0006036_abnormal_mitochondrial_physio0.74094816
156MP0008995_early_reproductive_senescence0.73929976
157MP0003943_abnormal_hepatobiliary_system0.73752131
158MP0004134_abnormal_chest_morphology0.73663189
159MP0002114_abnormal_axial_skeleton0.73260867
160MP0001784_abnormal_fluid_regulation0.72548389
161MP0001944_abnormal_pancreas_morphology0.72545916
162MP0008875_abnormal_xenobiotic_pharmacok0.72337683
163MP0003303_peritoneal_inflammation0.72279202
164MP0005195_abnormal_posterior_eye0.72135500
165MP0000432_abnormal_head_morphology0.71670856
166MP0005423_abnormal_somatic_nervous0.71227680
167MP0003137_abnormal_impulse_conducting0.71110206
168MP0002210_abnormal_sex_determination0.70050002
169MP0000537_abnormal_urethra_morphology0.69379234
170MP0002116_abnormal_craniofacial_bone0.68943735
171MP0000685_abnormal_immune_system0.67881390
172MP0001145_abnormal_male_reproductive0.67676033
173MP0001293_anophthalmia0.67656850
174MP0002081_perinatal_lethality0.67465380
175MP0003786_premature_aging0.67041563
176MP0004133_heterotaxia0.66111062
177MP0002075_abnormal_coat/hair_pigmentati0.65488943
178MP0002693_abnormal_pancreas_physiology0.64926138
179MP0002420_abnormal_adaptive_immunity0.62699574
180MP0001929_abnormal_gametogenesis0.61428822

Predicted human phenotypes

RankGene SetZ-score
1Volvulus (HP:0002580)4.97544558
2Pancreatic cysts (HP:0001737)4.09198924
3Abnormality of midbrain morphology (HP:0002418)3.98671663
4Molar tooth sign on MRI (HP:0002419)3.98671663
5Abnormality of the fingertips (HP:0001211)3.57258350
6Pancreatic fibrosis (HP:0100732)3.54933792
7Abnormality of the renal cortex (HP:0011035)3.51152266
8Focal motor seizures (HP:0011153)3.31570423
9Type II lissencephaly (HP:0007260)3.27587967
10Nephronophthisis (HP:0000090)3.26165686
11Increased nuchal translucency (HP:0010880)3.22644890
12True hermaphroditism (HP:0010459)3.14867941
13Papilledema (HP:0001085)3.12082921
14Congenital stationary night blindness (HP:0007642)3.10911079
15Hyperacusis (HP:0010780)2.98482443
16Febrile seizures (HP:0002373)2.92129467
17Neoplasm of the adrenal cortex (HP:0100641)2.88594751
18Abnormality of the renal medulla (HP:0100957)2.79953360
19Macroorchidism (HP:0000053)2.77518145
20Facial hemangioma (HP:0000329)2.73853723
21Hyperventilation (HP:0002883)2.72572398
22Basal cell carcinoma (HP:0002671)2.72415415
23Renal cortical cysts (HP:0000803)2.70965420
24Aplasia/Hypoplasia of the uvula (HP:0010293)2.64767928
25Long eyelashes (HP:0000527)2.62437297
26Attenuation of retinal blood vessels (HP:0007843)2.61196640
27Large for gestational age (HP:0001520)2.56214354
28Focal seizures (HP:0007359)2.54578238
29Hemiparesis (HP:0001269)2.49149077
30Abnormal drinking behavior (HP:0030082)2.42911440
31Polydipsia (HP:0001959)2.42911440
32Cutaneous melanoma (HP:0012056)2.41918199
33Gaze-evoked nystagmus (HP:0000640)2.40299398
34Acute lymphatic leukemia (HP:0006721)2.40174432
35Inability to walk (HP:0002540)2.37577307
36Abnormal rod and cone electroretinograms (HP:0008323)2.37041506
37Tubular atrophy (HP:0000092)2.36776225
38Cystic liver disease (HP:0006706)2.35705064
39Lissencephaly (HP:0001339)2.32641707
40Progressive inability to walk (HP:0002505)2.32181804
41Hypothermia (HP:0002045)2.30508207
42Obsessive-compulsive behavior (HP:0000722)2.28461986
43Asymmetry of the thorax (HP:0001555)2.27907811
44Short 4th metacarpal (HP:0010044)2.27679783
45Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.27679783
46Renal duplication (HP:0000075)2.22978535
47Chronic hepatic failure (HP:0100626)2.21335392
48Medial flaring of the eyebrow (HP:0010747)2.19949471
49Neoplasm of the oral cavity (HP:0100649)2.19774490
50Polyuria (HP:0000103)2.19145351
51Dialeptic seizures (HP:0011146)2.17939717
52Furrowed tongue (HP:0000221)2.17909069
53Epileptic encephalopathy (HP:0200134)2.13562373
54Myelodysplasia (HP:0002863)2.13035668
55Missing ribs (HP:0000921)2.12559773
56Progressive macrocephaly (HP:0004481)2.12536476
57Asplenia (HP:0001746)2.12205816
58Panhypogammaglobulinemia (HP:0003139)2.12117150
59Broad-based gait (HP:0002136)2.11518997
60Poikiloderma (HP:0001029)2.10756599
61Thick eyebrow (HP:0000574)2.10191138
62Abnormal delayed hypersensitivity skin test (HP:0002963)2.09559917
63Squamous cell carcinoma (HP:0002860)2.09406221
64Cellulitis (HP:0100658)2.08399133
65Sclerocornea (HP:0000647)2.08317826
66Abnormality of the pons (HP:0007361)2.06634686
67Severe muscular hypotonia (HP:0006829)2.04450767
68Heterotopia (HP:0002282)2.03673629
69Hypomagnesemia (HP:0002917)2.03348221
70Truncal obesity (HP:0001956)2.02820209
71Medulloblastoma (HP:0002885)2.02003628
72Cerebellar dysplasia (HP:0007033)2.01730587
73Abnormality of the ileum (HP:0001549)2.01511240
74Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.01026243
75Abnormality of alanine metabolism (HP:0010916)2.01026243
76Hyperalaninemia (HP:0003348)2.01026243
77Proximal placement of thumb (HP:0009623)2.00504619
78Increased circulating renin level (HP:0000848)1.99335566
79Meckel diverticulum (HP:0002245)1.98773561
80Bile duct proliferation (HP:0001408)1.97903885
81Abnormal biliary tract physiology (HP:0012439)1.97903885
82Ketoacidosis (HP:0001993)1.97195583
83Anencephaly (HP:0002323)1.97195340
84Pendular nystagmus (HP:0012043)1.97080538
85Fair hair (HP:0002286)1.95968787
86Hyperglycinuria (HP:0003108)1.95730495
87T lymphocytopenia (HP:0005403)1.95081762
88Deviation of the thumb (HP:0009603)1.95028509
89Concave nail (HP:0001598)1.94602867
9011 pairs of ribs (HP:0000878)1.94253286
91Bilateral microphthalmos (HP:0007633)1.93402652
92Metabolic alkalosis (HP:0200114)1.93372682
93Protruding tongue (HP:0010808)1.92014231
94Subacute progressive viral hepatitis (HP:0006572)1.91002689
95Aplasia/Hypoplasia of the tongue (HP:0010295)1.90774631
96Colon cancer (HP:0003003)1.89760079
97Agammaglobulinemia (HP:0004432)1.89061628
98Hypoplasia of the pons (HP:0012110)1.88942366
993-Methylglutaconic aciduria (HP:0003535)1.88838155
100Abnormal number of incisors (HP:0011064)1.88687592
101Oligodactyly (HP:0012165)1.88580489
102Viral hepatitis (HP:0006562)1.88489182
103Abolished electroretinogram (ERG) (HP:0000550)1.88330166
104Rib fusion (HP:0000902)1.88288615
105Reticulocytopenia (HP:0001896)1.86432135
106Urethral obstruction (HP:0000796)1.85873047
107Acute necrotizing encephalopathy (HP:0006965)1.85855959
108Stomach cancer (HP:0012126)1.85448509
109Decreased central vision (HP:0007663)1.85250051
110Aplasia/Hypoplasia of the spleen (HP:0010451)1.85170207
111Overriding aorta (HP:0002623)1.84599573
112Insomnia (HP:0100785)1.84348760
113Broad thumb (HP:0011304)1.83954283
114Recurrent viral infections (HP:0004429)1.83810741
115Supernumerary spleens (HP:0009799)1.83717122
116Flat cornea (HP:0007720)1.83449465
117Absent speech (HP:0001344)1.82231457
118Disproportionate short-trunk short stature (HP:0003521)1.81798137
119Spontaneous hematomas (HP:0007420)1.81786540
120Broad palm (HP:0001169)1.81664122
121Pachygyria (HP:0001302)1.79849098
122Chromsome breakage (HP:0040012)1.79722717
123Supernumerary ribs (HP:0005815)1.79416178
124Supernumerary bones of the axial skeleton (HP:0009144)1.79022102
125Dynein arm defect of respiratory motile cilia (HP:0012255)1.78598517
126Absent/shortened dynein arms (HP:0200106)1.78598517
127Increased corneal curvature (HP:0100692)1.78174044
128Keratoconus (HP:0000563)1.78174044
129Bulbous nose (HP:0000414)1.77599369
130Renovascular hypertension (HP:0100817)1.77350202
131Progressive cerebellar ataxia (HP:0002073)1.76716947
132Absent thumb (HP:0009777)1.76078216
133Aplasia/Hypoplasia of the patella (HP:0006498)1.76019444
134Nephroblastoma (Wilms tumor) (HP:0002667)1.76005371
135Increased CSF lactate (HP:0002490)1.75910753
136Acute encephalopathy (HP:0006846)1.75459291
137Abnormality of T cell number (HP:0011839)1.75375223
138Limb dystonia (HP:0002451)1.75085632
139Cutis marmorata (HP:0000965)1.74485877
140Abnormality of chromosome stability (HP:0003220)1.73727491
141Prominent nose (HP:0000448)1.73415140
142Papilloma (HP:0012740)1.72750673
143Verrucae (HP:0200043)1.72750673
144Widely spaced teeth (HP:0000687)1.72051234
145Somatic mutation (HP:0001428)1.72021778
146Epileptiform EEG discharges (HP:0011182)1.72006688
147Male pseudohermaphroditism (HP:0000037)1.71269466
148Hypoplastic ischia (HP:0003175)1.71228886
149Oligodactyly (hands) (HP:0001180)1.70816814
150Congenital, generalized hypertrichosis (HP:0004540)1.70777182
151Hypsarrhythmia (HP:0002521)1.70641260
152Deep philtrum (HP:0002002)1.70556178
153Bicuspid aortic valve (HP:0001647)1.69932395
154Atonic seizures (HP:0010819)1.69862836
155Absent rod-and cone-mediated responses on ERG (HP:0007688)1.68723790
156High pitched voice (HP:0001620)1.68246541
157Elfin facies (HP:0004428)1.68225070
158Rhabdomyosarcoma (HP:0002859)1.67873025
159Hypotelorism (HP:0000601)1.67790081
160Hypoplastic iliac wings (HP:0002866)1.67485638
161Broad phalanges of the hand (HP:0009768)1.67477565
162Abnormality of the diencephalon (HP:0010662)1.67377898
163Intestinal atresia (HP:0011100)1.67177325
164Duplicated collecting system (HP:0000081)1.66915059
165EEG with generalized epileptiform discharges (HP:0011198)1.66657738
166Patellar aplasia (HP:0006443)1.66576692
167Neoplasm of striated muscle (HP:0009728)1.65632905
168Type 2 muscle fiber atrophy (HP:0003554)1.65535157
169Thrombocytosis (HP:0001894)1.65471186
170Birth length less than 3rd percentile (HP:0003561)1.65182177
171Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.64546084
172Thyroiditis (HP:0100646)1.63828987
173Acute myeloid leukemia (HP:0004808)1.63736605
174Syringomyelia (HP:0003396)1.63056986
175Spinal cord lesions (HP:0100561)1.63056986
176Aqueductal stenosis (HP:0002410)1.62820434
177Increased number of teeth (HP:0011069)1.61296079
178Pointed chin (HP:0000307)1.60899781
179Intestinal malrotation (HP:0002566)1.60411058
180Dislocated radial head (HP:0003083)1.59940902
181Abnormality of the labia minora (HP:0012880)1.59441648
182Orthostatic hypotension (HP:0001278)1.59212027
183Embryonal renal neoplasm (HP:0011794)1.58755106
184Atresia of the external auditory canal (HP:0000413)1.58362316
185Broad finger (HP:0001500)1.58149773
186Exostoses (HP:0100777)1.57806660
187Lower limb asymmetry (HP:0100559)1.57539043
188Annular pancreas (HP:0001734)1.57470086
189Tented upper lip vermilion (HP:0010804)1.56642976
190Vertebral arch anomaly (HP:0008438)1.55844046
191Ependymoma (HP:0002888)1.55099506
192Abnormality of the radial head (HP:0003995)1.54556866
193Sacral dimple (HP:0000960)1.54510811
194Bladder carcinoma (HP:0002862)1.54046863
195Bladder neoplasm (HP:0009725)1.54046863
196Abnormality of the carotid arteries (HP:0005344)1.54011080

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK123.70501746
2CDC73.16627236
3MAP3K102.75479528
4WNK42.72233196
5BMPR1B2.66456694
6ADRBK22.65488456
7NUAK12.60669521
8BRD42.40935844
9EEF2K2.32482546
10PINK12.22190314
11STK392.19374633
12PASK2.18778703
13NEK22.17616332
14PKN22.09791558
15DAPK22.07247044
16ALK2.05766655
17WNK32.05053882
18TAF12.03904346
19MAPK131.98835596
20PRKD31.97282097
21SIK21.82248685
22MKNK11.80281513
23HIPK21.77296819
24MARK11.74803725
25TNIK1.70700494
26PRKD21.68976840
27TYRO31.66047292
28GRK11.65348396
29ZAK1.64596811
30NTRK31.62716876
31CDK61.60706240
32MKNK21.59285149
33ACVR1B1.56764519
34OXSR11.52991401
35MAP4K11.51998041
36CDK91.47791682
37VRK21.47293847
38ICK1.45051835
39TLK11.40845867
40CASK1.40739275
41MAP3K41.36721828
42UHMK11.35912718
43PLK21.34951597
44PDGFRA1.33618130
45FRK1.33057328
46FGFR21.29851336
47INSRR1.28374452
48CDK71.27997771
49TAOK31.23125056
50FGFR31.22754807
51MAP4K21.19726925
52CDK41.19484411
53BRSK21.16021846
54TSSK61.15330611
55ATR1.14694864
56PHKG21.14450668
57PHKG11.14450668
58PAK31.13897372
59CAMK1G1.13825199
60CLK11.12350770
61CCNB11.11731716
62PIM11.10758756
63EIF2AK11.10450663
64CHEK11.08958088
65PNCK1.07005157
66STK38L1.06995470
67CDK81.05529255
68YES11.04804304
69MAPKAPK51.02830482
70PLK11.01545053
71* CDK21.01476091
72PRKCG1.01040863
73TRIB31.00817171
74RPS6KB21.00610343
75PDGFRB1.00331769
76STK30.99810546
77EPHA30.99482481
78EPHA40.99179800
79AKT30.98715623
80TRIM280.98609490
81MST40.98367288
82GRK60.97985291
83NTRK20.95960368
84CHEK20.95934632
85EIF2AK30.94803071
86STK100.93016194
87PTK60.91736121
88MTOR0.90083010
89DYRK20.87611469
90CHUK0.87404002
91TTK0.87393310
92STK40.87289707
93NLK0.85694997
94FLT30.84503696
95ATM0.83988745
96PRKCH0.83086967
97BMX0.82137090
98CSNK1A1L0.81944837
99SYK0.78574168
100ADRBK10.78573119
101JAK30.77661237
102AURKB0.77036264
103VRK10.74712656
104RPS6KB10.74662040
105RIPK40.74466323
106CDK10.74333579
107MELK0.72417374
108PRKCE0.71940148
109CSNK1G30.71861523
110TGFBR10.71741105
111DYRK30.71326385
112DMPK0.70497291
113PRKCI0.70405089
114* MAPK140.70349233
115MARK20.70312071
116WEE10.69336832
117STK380.68659991
118WNK10.68197520
119LATS10.67924995
120CSNK1G10.67136020
121MAP3K60.65730945
122TEC0.65627378
123DAPK10.65389526
124CDC42BPA0.64545743
125STK110.64197588
126GRK50.63334458
127CSNK1G20.63056938
128PLK30.61971644
129PRKCQ0.61349471
130RPS6KA40.60850439
131PRKDC0.58986602
132* GSK3B0.58802173
133BUB10.58264502
134FGR0.57414407
135CSNK1D0.56917131
136TNK20.56855668
137CAMK1D0.55568146
138BTK0.54919652
139MAPK100.54171555
140LCK0.54081534
141BRSK10.53808302
142DYRK1A0.52388926
143PTK2B0.52011073
144RPS6KC10.51850268
145RPS6KL10.51850268
146MUSK0.51441605
147CSNK2A20.51376901
148AKT10.49801753
149SGK20.49309763
150MAPKAPK30.49089694
151RPS6KA60.47859779
152LRRK20.46835451
153CAMK2A0.45911923
154MAP2K60.40906502
155ERBB30.39237177
156EIF2AK20.39003175
157STK160.38950208
158PRKAA10.37496771
159CAMK10.34820903
160CSNK1E0.34093918
161CSNK1A10.33671530
162CAMKK20.33575028
163IRAK10.33433754
164PRKACA0.32937529
165CDK30.32837920
166IKBKB0.31618302
167MAP3K90.31087164
168PRKCZ0.30806938
169TXK0.30794357

Predicted pathways (KEGG)

RankGene SetZ-score
1Phototransduction_Homo sapiens_hsa047443.11382736
2Maturity onset diabetes of the young_Homo sapiens_hsa049502.73926823
3Mismatch repair_Homo sapiens_hsa034302.56286964
4Nicotine addiction_Homo sapiens_hsa050332.52999387
5Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.48238235
6Butanoate metabolism_Homo sapiens_hsa006502.38695647
7Base excision repair_Homo sapiens_hsa034102.32647661
8DNA replication_Homo sapiens_hsa030302.27982236
9Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.25632159
10Nitrogen metabolism_Homo sapiens_hsa009102.21672452
11alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.15803745
12Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.03721481
13Linoleic acid metabolism_Homo sapiens_hsa005911.99940387
14Selenocompound metabolism_Homo sapiens_hsa004501.95810473
15Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.92686272
16Cell cycle_Homo sapiens_hsa041101.80927054
17mRNA surveillance pathway_Homo sapiens_hsa030151.76680763
18Spliceosome_Homo sapiens_hsa030401.74178428
19Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.68924285
20RNA transport_Homo sapiens_hsa030131.64773430
21Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.60084998
22B cell receptor signaling pathway_Homo sapiens_hsa046621.54606574
23Oxidative phosphorylation_Homo sapiens_hsa001901.53264924
24Ether lipid metabolism_Homo sapiens_hsa005651.47512450
25Taste transduction_Homo sapiens_hsa047421.47301422
26Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.46237015
27Chronic myeloid leukemia_Homo sapiens_hsa052201.42730020
28Homologous recombination_Homo sapiens_hsa034401.37712303
29Primary immunodeficiency_Homo sapiens_hsa053401.36608137
30Propanoate metabolism_Homo sapiens_hsa006401.36031385
31Ribosome_Homo sapiens_hsa030101.28530360
32Colorectal cancer_Homo sapiens_hsa052101.26549822
33Oocyte meiosis_Homo sapiens_hsa041141.26309149
34GABAergic synapse_Homo sapiens_hsa047271.25738024
35Long-term potentiation_Homo sapiens_hsa047201.25383306
36MicroRNAs in cancer_Homo sapiens_hsa052061.23296542
37Transcriptional misregulation in cancer_Homo sapiens_hsa052021.23088521
38Non-small cell lung cancer_Homo sapiens_hsa052231.22580570
39Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.22507956
40RNA degradation_Homo sapiens_hsa030181.22196448
41Parkinsons disease_Homo sapiens_hsa050121.21282241
42Non-homologous end-joining_Homo sapiens_hsa034501.19651167
43Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.19305310
44Regulation of autophagy_Homo sapiens_hsa041401.19270237
45Nucleotide excision repair_Homo sapiens_hsa034201.19004976
46mTOR signaling pathway_Homo sapiens_hsa041501.18180055
47Fanconi anemia pathway_Homo sapiens_hsa034601.13656176
48Dorso-ventral axis formation_Homo sapiens_hsa043201.11861636
49Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.11585076
50Wnt signaling pathway_Homo sapiens_hsa043101.10864824
51Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.10702359
52Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.09779543
53HTLV-I infection_Homo sapiens_hsa051661.09646118
54Thyroid hormone signaling pathway_Homo sapiens_hsa049191.09025165
55Collecting duct acid secretion_Homo sapiens_hsa049661.08834885
56Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.06897722
57Endometrial cancer_Homo sapiens_hsa052131.06785064
58Glioma_Homo sapiens_hsa052141.06067625
59Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.05934067
60Serotonergic synapse_Homo sapiens_hsa047261.02256766
61Neurotrophin signaling pathway_Homo sapiens_hsa047221.00071943
62Circadian rhythm_Homo sapiens_hsa047100.99649706
63Cardiac muscle contraction_Homo sapiens_hsa042600.98664139
64Acute myeloid leukemia_Homo sapiens_hsa052210.97167186
65Tryptophan metabolism_Homo sapiens_hsa003800.97078713
66Lysine degradation_Homo sapiens_hsa003100.96280144
67Notch signaling pathway_Homo sapiens_hsa043300.95733517
68Calcium signaling pathway_Homo sapiens_hsa040200.95574108
69Thyroid cancer_Homo sapiens_hsa052160.94331130
70Pancreatic cancer_Homo sapiens_hsa052120.90572149
71Viral carcinogenesis_Homo sapiens_hsa052030.90427651
72Basal cell carcinoma_Homo sapiens_hsa052170.89836019
73Prostate cancer_Homo sapiens_hsa052150.88962826
74Estrogen signaling pathway_Homo sapiens_hsa049150.88043702
75Salivary secretion_Homo sapiens_hsa049700.87489357
76VEGF signaling pathway_Homo sapiens_hsa043700.86969989
77Small cell lung cancer_Homo sapiens_hsa052220.86329570
78T cell receptor signaling pathway_Homo sapiens_hsa046600.84650915
79Hepatitis B_Homo sapiens_hsa051610.84557578
80Phosphatidylinositol signaling system_Homo sapiens_hsa040700.84166917
81p53 signaling pathway_Homo sapiens_hsa041150.83986791
82Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.83781864
83Intestinal immune network for IgA production_Homo sapiens_hsa046720.82278518
84Caffeine metabolism_Homo sapiens_hsa002320.81544423
85Platelet activation_Homo sapiens_hsa046110.81537923
86ErbB signaling pathway_Homo sapiens_hsa040120.81410265
87Dopaminergic synapse_Homo sapiens_hsa047280.81192551
88Type I diabetes mellitus_Homo sapiens_hsa049400.80783081
89Hedgehog signaling pathway_Homo sapiens_hsa043400.80673966
90MAPK signaling pathway_Homo sapiens_hsa040100.80074197
91SNARE interactions in vesicular transport_Homo sapiens_hsa041300.79771323
92Aldosterone synthesis and secretion_Homo sapiens_hsa049250.79749390
93Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.79649590
94Amphetamine addiction_Homo sapiens_hsa050310.79613309
95Long-term depression_Homo sapiens_hsa047300.79592565
96Purine metabolism_Homo sapiens_hsa002300.78319588
97Protein export_Homo sapiens_hsa030600.78143619
98FoxO signaling pathway_Homo sapiens_hsa040680.76292462
99Hippo signaling pathway_Homo sapiens_hsa043900.76155937
100Herpes simplex infection_Homo sapiens_hsa051680.75707100
101Olfactory transduction_Homo sapiens_hsa047400.75342485
102Insulin secretion_Homo sapiens_hsa049110.75144934
103One carbon pool by folate_Homo sapiens_hsa006700.74515117
104Epstein-Barr virus infection_Homo sapiens_hsa051690.74380670
105AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.72591489
106Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.72406433
107Alzheimers disease_Homo sapiens_hsa050100.72276424
108Peroxisome_Homo sapiens_hsa041460.72114966
109Melanogenesis_Homo sapiens_hsa049160.72108795
110Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.71657376
111Longevity regulating pathway - mammal_Homo sapiens_hsa042110.70890355
112ABC transporters_Homo sapiens_hsa020100.70369179
113Choline metabolism in cancer_Homo sapiens_hsa052310.70288296
114Cholinergic synapse_Homo sapiens_hsa047250.69582995
115Gastric acid secretion_Homo sapiens_hsa049710.68378347
116Glutamatergic synapse_Homo sapiens_hsa047240.67847985
117Gap junction_Homo sapiens_hsa045400.67778057
118GnRH signaling pathway_Homo sapiens_hsa049120.67777406
119Pathways in cancer_Homo sapiens_hsa052000.67188204
120Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.66319420
121cAMP signaling pathway_Homo sapiens_hsa040240.65409357
122Huntingtons disease_Homo sapiens_hsa050160.64408040
123Cocaine addiction_Homo sapiens_hsa050300.64355530
124Adherens junction_Homo sapiens_hsa045200.64305513
125Vitamin B6 metabolism_Homo sapiens_hsa007500.64111282
126Prolactin signaling pathway_Homo sapiens_hsa049170.63708778
127Circadian entrainment_Homo sapiens_hsa047130.63705536
128Renal cell carcinoma_Homo sapiens_hsa052110.63039284
129cGMP-PKG signaling pathway_Homo sapiens_hsa040220.62618648
130Oxytocin signaling pathway_Homo sapiens_hsa049210.62425052
131Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.62304414
132Morphine addiction_Homo sapiens_hsa050320.62125164
133Ovarian steroidogenesis_Homo sapiens_hsa049130.61670069
134Proteoglycans in cancer_Homo sapiens_hsa052050.60926960
135RNA polymerase_Homo sapiens_hsa030200.60784967
136Osteoclast differentiation_Homo sapiens_hsa043800.60755499
137Renin secretion_Homo sapiens_hsa049240.59396701
138Chemokine signaling pathway_Homo sapiens_hsa040620.59395863
139Measles_Homo sapiens_hsa051620.59104585
140Type II diabetes mellitus_Homo sapiens_hsa049300.57741499
141Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.57234842
142Basal transcription factors_Homo sapiens_hsa030220.56542283
143Antigen processing and presentation_Homo sapiens_hsa046120.56469025
144Viral myocarditis_Homo sapiens_hsa054160.56454928
145Vascular smooth muscle contraction_Homo sapiens_hsa042700.55094707
146beta-Alanine metabolism_Homo sapiens_hsa004100.54780143
147Synaptic vesicle cycle_Homo sapiens_hsa047210.51025046
148Sulfur relay system_Homo sapiens_hsa041220.50186552
149Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.49428997
150Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.49047375
151Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.48823827
152Arachidonic acid metabolism_Homo sapiens_hsa005900.48020565
153Mineral absorption_Homo sapiens_hsa049780.46336644
154Proteasome_Homo sapiens_hsa030500.42371341
155Asthma_Homo sapiens_hsa053100.39165899
156Cysteine and methionine metabolism_Homo sapiens_hsa002700.37338851
157Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.37019567
158Pyrimidine metabolism_Homo sapiens_hsa002400.34742848
159Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.34481524
160Sulfur metabolism_Homo sapiens_hsa009200.33149429
161TGF-beta signaling pathway_Homo sapiens_hsa043500.32487274
162Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.31243231
163Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.30316883

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