TENM2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1hemidesmosome assembly (GO:0031581)9.99588656
2neuron cell-cell adhesion (GO:0007158)5.65379208
3vocalization behavior (GO:0071625)5.55522555
4regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.07205200
5regulation of short-term neuronal synaptic plasticity (GO:0048172)5.02654739
6ionotropic glutamate receptor signaling pathway (GO:0035235)4.97601161
7protein localization to synapse (GO:0035418)4.93240453
8positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.80507038
9neuron recognition (GO:0008038)4.75643459
10glutamate receptor signaling pathway (GO:0007215)4.75559118
11synaptic vesicle exocytosis (GO:0016079)4.73577535
12desmosome organization (GO:0002934)4.73321357
13positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.69295092
14regulation of glutamate receptor signaling pathway (GO:1900449)4.56868700
15bundle of His cell to Purkinje myocyte communication (GO:0086069)4.40712264
16axonal fasciculation (GO:0007413)4.28243919
17regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.23737968
18exploration behavior (GO:0035640)4.20526597
19locomotory exploration behavior (GO:0035641)4.18278163
20dendritic spine morphogenesis (GO:0060997)4.14801879
21synaptic transmission, glutamatergic (GO:0035249)4.13554379
22presynaptic membrane assembly (GO:0097105)4.13238453
23glutamate secretion (GO:0014047)4.10909380
24cell-substrate junction assembly (GO:0007044)4.09624322
25neuron-neuron synaptic transmission (GO:0007270)4.06567855
26regulation of long-term neuronal synaptic plasticity (GO:0048169)4.01503387
27regulation of synaptic vesicle exocytosis (GO:2000300)4.01401653
28postsynaptic membrane organization (GO:0001941)3.97923268
29cell communication involved in cardiac conduction (GO:0086065)3.97482004
30gamma-aminobutyric acid signaling pathway (GO:0007214)3.92758220
31response to histamine (GO:0034776)3.83543395
32negative regulation of keratinocyte proliferation (GO:0010839)3.80728633
33regulation of neuronal synaptic plasticity (GO:0048168)3.79687310
34regulation of excitatory postsynaptic membrane potential (GO:0060079)3.76326075
35presynaptic membrane organization (GO:0097090)3.74800520
36G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.73924681
37synaptic vesicle maturation (GO:0016188)3.73240286
38axon extension involved in axon guidance (GO:0048846)3.71148660
39neuron projection extension involved in neuron projection guidance (GO:1902284)3.71148660
40layer formation in cerebral cortex (GO:0021819)3.70089970
41neurotransmitter secretion (GO:0007269)3.66414276
42regulation of postsynaptic membrane potential (GO:0060078)3.66240716
43regulation of synaptic vesicle transport (GO:1902803)3.63193069
44regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.62302404
45neuronal action potential propagation (GO:0019227)3.60967270
46neurotransmitter-gated ion channel clustering (GO:0072578)3.55490410
47synaptic vesicle endocytosis (GO:0048488)3.54967774
48intermediate filament organization (GO:0045109)3.54896342
49axon extension (GO:0048675)3.52551073
50positive regulation of synapse maturation (GO:0090129)3.51930566
51long-term memory (GO:0007616)3.46171227
52regulation of vesicle fusion (GO:0031338)3.45904061
53synaptic vesicle docking involved in exocytosis (GO:0016081)3.44536617
54transmission of nerve impulse (GO:0019226)3.42438266
55cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.42392425
56regulation of synapse structural plasticity (GO:0051823)3.41778958
57behavioral defense response (GO:0002209)3.41167325
58behavioral fear response (GO:0001662)3.41167325
59positive regulation of synapse assembly (GO:0051965)3.38961960
60regulation of dendritic spine morphogenesis (GO:0061001)3.37935954
61cell communication by electrical coupling (GO:0010644)3.37809063
62keratinocyte proliferation (GO:0043616)3.36998881
63fear response (GO:0042596)3.34783240
64positive regulation of membrane potential (GO:0045838)3.34095146
65innervation (GO:0060384)3.34068331
66G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.33789415
67positive regulation of neurotransmitter secretion (GO:0001956)3.33655082
68membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.30278094
69cell adhesion mediated by integrin (GO:0033627)3.29838244
70regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.29696654
71proline transport (GO:0015824)3.29544660
72long-term synaptic potentiation (GO:0060291)3.28259272
73regulation of synaptic transmission, glutamatergic (GO:0051966)3.28041580
74neurotransmitter transport (GO:0006836)3.25680154
75negative regulation of microtubule polymerization (GO:0031115)3.25506081
76startle response (GO:0001964)3.25098121
77synapse assembly (GO:0007416)3.24350603
78ventricular cardiac muscle cell action potential (GO:0086005)3.23631616
79pyrimidine nucleobase catabolic process (GO:0006208)3.23240844
80lateral sprouting from an epithelium (GO:0060601)3.22575441
81regulation of synaptic plasticity (GO:0048167)3.22349861
82behavioral response to cocaine (GO:0048148)3.22345431
83regulation of axon guidance (GO:1902667)3.22187544
84regulation of glutamate secretion (GO:0014048)3.21403679
85endodermal cell differentiation (GO:0035987)3.19522839
86establishment of tissue polarity (GO:0007164)3.19047508
87establishment of planar polarity (GO:0001736)3.19047508
88negative regulation of synaptic transmission, GABAergic (GO:0032229)3.18985455
89detection of calcium ion (GO:0005513)3.18458709
90central nervous system projection neuron axonogenesis (GO:0021952)3.18363750
91dendrite morphogenesis (GO:0048813)3.17248678
92cell migration in hindbrain (GO:0021535)3.16939182
93positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.16577366
94regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.15337914
95positive regulation of neurotransmitter transport (GO:0051590)3.14167797
96membrane depolarization (GO:0051899)3.14124341
97cochlea development (GO:0090102)3.12371911
98learning (GO:0007612)3.09994530
99positive regulation of dendritic spine development (GO:0060999)3.09399919
100regulation of axon extension involved in axon guidance (GO:0048841)3.08420580
101regulation of dendritic spine development (GO:0060998)3.06452531
102regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.04871872
103dendritic spine organization (GO:0097061)3.03485378
104regulation of neurotransmitter secretion (GO:0046928)3.02725382
105positive regulation of dendritic spine morphogenesis (GO:0061003)3.02508832
106neuron projection extension (GO:1990138)3.01639159
107positive regulation of action potential (GO:0045760)3.01242776
108auditory behavior (GO:0031223)2.99733814
109mating behavior (GO:0007617)2.98931719
110social behavior (GO:0035176)2.98593350
111intraspecies interaction between organisms (GO:0051703)2.98593350
112gamma-aminobutyric acid transport (GO:0015812)2.98005919
113positive regulation of synaptic transmission, GABAergic (GO:0032230)2.97421058
114membrane depolarization during action potential (GO:0086010)2.96940307
115dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.96655487
116synapse organization (GO:0050808)2.96580317
117regulation of neurotransmitter levels (GO:0001505)2.96475057
118cerebellar Purkinje cell differentiation (GO:0021702)2.95552006
119negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.94281438
120regulation of respiratory system process (GO:0044065)2.93899705
121negative chemotaxis (GO:0050919)2.93807787
122membrane hyperpolarization (GO:0060081)2.93356795
123righting reflex (GO:0060013)2.92277794
124positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.91326237
125cardiac myofibril assembly (GO:0055003)2.90574978
126regulation of synapse assembly (GO:0051963)2.90495060
127regulation of dopamine metabolic process (GO:0042053)2.89768713
128regulation of catecholamine metabolic process (GO:0042069)2.89768713
129sarcomere organization (GO:0045214)2.86439474
130synaptic transmission (GO:0007268)2.85140633
131negative regulation of axon guidance (GO:1902668)2.84939728
132regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.84387563
133regulation of keratinocyte proliferation (GO:0010837)2.79465003
134intermediate filament cytoskeleton organization (GO:0045104)2.69325887
135neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.67237470
136intermediate filament-based process (GO:0045103)2.66588913
137sodium ion export (GO:0071436)2.65429970
138homophilic cell adhesion via plasma membrane adhesion molecules (GO:0007156)2.61286126
139cardiac right ventricle morphogenesis (GO:0003215)2.61180222
140calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.60356171
141suckling behavior (GO:0001967)2.58977950
142regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.55421378
143cardiac muscle cell action potential (GO:0086001)2.54992466
144negative regulation of axon extension involved in axon guidance (GO:0048843)2.53717495
145cardiac muscle cell action potential involved in contraction (GO:0086002)2.51884708
146developmental cell growth (GO:0048588)2.51019219
147negative regulation of protein localization to cell surface (GO:2000009)2.50976450
148nucleobase catabolic process (GO:0046113)2.48253038
149limb bud formation (GO:0060174)2.47903490
150camera-type eye morphogenesis (GO:0048593)2.47609666
151regulation of heart rate by cardiac conduction (GO:0086091)2.46834130
152positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.45842798
153ventricular cardiac muscle tissue morphogenesis (GO:0055010)2.45727106
154heparan sulfate proteoglycan metabolic process (GO:0030201)2.44247012
155cardiac conduction (GO:0061337)2.44105919
156gap junction assembly (GO:0016264)2.43379954
157establishment of skin barrier (GO:0061436)2.42136080
158cardiac muscle contraction (GO:0060048)2.41698665
159heparan sulfate proteoglycan biosynthetic process (GO:0015012)2.38960966
160negative regulation of chondrocyte differentiation (GO:0032331)2.38456779
161skin morphogenesis (GO:0043589)2.38028712
162urinary tract smooth muscle contraction (GO:0014848)2.37396113
163epidermis development (GO:0008544)2.36951254
164ganglion development (GO:0061548)2.35326673
165collagen fibril organization (GO:0030199)2.34097686
166negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.32588489
167regulation of cell communication by electrical coupling (GO:0010649)2.32480010
168apical protein localization (GO:0045176)2.31295967
169regulation of actin filament-based movement (GO:1903115)2.29017083
170membrane assembly (GO:0071709)2.27413982
171cardiac muscle tissue morphogenesis (GO:0055008)2.27245923

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.28463177
2TP63_17297297_ChIP-ChIP_HaCaT_Human6.26152328
3GBX2_23144817_ChIP-Seq_PC3_Human3.97500148
4JARID2_20064375_ChIP-Seq_MESCs_Mouse3.12982206
5SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.08715652
6SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.00532048
7EZH2_27304074_Chip-Seq_ESCs_Mouse2.67580682
8SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.67180869
9JARID2_20075857_ChIP-Seq_MESCs_Mouse2.60730957
10RNF2_18974828_ChIP-Seq_MESCs_Mouse2.57306732
11EZH2_18974828_ChIP-Seq_MESCs_Mouse2.57306732
12SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.56756891
13REST_21632747_ChIP-Seq_MESCs_Mouse2.51386927
14TAF15_26573619_Chip-Seq_HEK293_Human2.47249994
15SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.46685547
16EED_16625203_ChIP-ChIP_MESCs_Mouse2.38123845
17MTF2_20144788_ChIP-Seq_MESCs_Mouse2.34912967
18SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.32545024
19GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.21571727
20RBPJ_22232070_ChIP-Seq_NCS_Mouse2.18029332
21CTBP1_25329375_ChIP-Seq_LNCAP_Human2.17785502
22CTBP2_25329375_ChIP-Seq_LNCAP_Human2.15695444
23SUZ12_27294783_Chip-Seq_ESCs_Mouse2.13569677
24EZH2_27294783_Chip-Seq_ESCs_Mouse2.13313894
25TRIM28_21343339_ChIP-Seq_HEK293_Human2.09856454
26RNF2_27304074_Chip-Seq_ESCs_Mouse2.08420463
27ZFP57_27257070_Chip-Seq_ESCs_Mouse2.07908938
28NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.07324400
29DROSHA_22980978_ChIP-Seq_HELA_Human1.95151440
30REST_18959480_ChIP-ChIP_MESCs_Mouse1.94866016
31IKZF1_21737484_ChIP-ChIP_HCT116_Human1.93782575
32RARB_27405468_Chip-Seq_BRAIN_Mouse1.93384400
33EP300_21415370_ChIP-Seq_HL-1_Mouse1.92956153
34AR_21572438_ChIP-Seq_LNCaP_Human1.88679492
35CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.83843302
36BMI1_23680149_ChIP-Seq_NPCS_Mouse1.79205775
37SMAD4_21799915_ChIP-Seq_A2780_Human1.78920382
38ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.78363073
39P300_19829295_ChIP-Seq_ESCs_Human1.78218381
40PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.73315581
41CBX2_27304074_Chip-Seq_ESCs_Mouse1.71976403
42RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.68499544
43* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.62926876
44ZNF274_21170338_ChIP-Seq_K562_Hela1.61922198
45GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.61562754
46IGF1R_20145208_ChIP-Seq_DFB_Human1.60728567
47POU3F2_20337985_ChIP-ChIP_501MEL_Human1.58774008
48FUS_26573619_Chip-Seq_HEK293_Human1.56423923
49PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.54342733
50SMAD3_21741376_ChIP-Seq_EPCs_Human1.54246537
51TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.51926421
52TOP2B_26459242_ChIP-Seq_MCF-7_Human1.51640673
53VDR_22108803_ChIP-Seq_LS180_Human1.50964399
54EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.46278817
55PIAS1_25552417_ChIP-Seq_VCAP_Human1.44689056
56RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.44608979
57SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.42596489
58NR3C1_23031785_ChIP-Seq_PC12_Mouse1.41404827
59RNF2_27304074_Chip-Seq_NSC_Mouse1.37564812
60AR_25329375_ChIP-Seq_VCAP_Human1.36838164
61OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.35915584
62CJUN_26792858_Chip-Seq_BT549_Human1.29935823
63SOX2_21211035_ChIP-Seq_LN229_Gbm1.29319797
64PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.28207749
65CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.27877168
66SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.27077359
67ERG_21242973_ChIP-ChIP_JURKAT_Human1.27041996
68RING1B_27294783_Chip-Seq_ESCs_Mouse1.25124455
69UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.24581715
70STAT6_21828071_ChIP-Seq_BEAS2B_Human1.22149956
71TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.18168077
72STAT3_23295773_ChIP-Seq_U87_Human1.17771186
73TP53_18474530_ChIP-ChIP_U2OS_Human1.17544039
74ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.17322138
75MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.16893332
76ARNT_22903824_ChIP-Seq_MCF-7_Human1.16789395
77TP53_16413492_ChIP-PET_HCT116_Human1.15104001
78AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.14337764
79RUNX2_22187159_ChIP-Seq_PCA_Human1.13606560
80AHR_22903824_ChIP-Seq_MCF-7_Human1.13398313
81KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.13365666
82POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.12792756
83TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12792756
84CDX2_19796622_ChIP-Seq_MESCs_Mouse1.12635647
85ZNF217_24962896_ChIP-Seq_MCF-7_Human1.12482951
86PRDM14_20953172_ChIP-Seq_ESCs_Human1.11371657
87TP53_20018659_ChIP-ChIP_R1E_Mouse1.11360883
88NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.11116812
89NRF2_20460467_ChIP-Seq_MEFs_Mouse1.11116812
90TCF4_23295773_ChIP-Seq_U87_Human1.11024952
91SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.10824916
92TCF4_18268006_ChIP-ChIP_LS174T_Human1.10071796
93BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.08468075
94RING1B_27294783_Chip-Seq_NPCs_Mouse1.08109523
95BCAT_22108803_ChIP-Seq_LS180_Human1.07854796
96TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.07603919
97NR3C1_21868756_ChIP-Seq_MCF10A_Human1.06488182
98WT1_19549856_ChIP-ChIP_CCG9911_Human1.05703268
99AR_19668381_ChIP-Seq_PC3_Human1.05654048
100NANOG_18555785_Chip-Seq_ESCs_Mouse1.05511641
101JUN_21703547_ChIP-Seq_K562_Human1.05499422
102LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05104180
103ER_23166858_ChIP-Seq_MCF-7_Human1.04481594
104* SOX9_24532713_ChIP-Seq_HFSC_Mouse1.04249739
105EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.03643485
106SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.03308724
107CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03004955
108MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.02897725
109P53_22127205_ChIP-Seq_FIBROBLAST_Human1.02005253
110SMAD3_21741376_ChIP-Seq_HESCs_Human1.01698570
111YAP1_20516196_ChIP-Seq_MESCs_Mouse0.99693051
112ISL1_27105846_Chip-Seq_CPCs_Mouse0.96990204
113TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96459876
114TP63_23658742_ChIP-Seq_EP156T_Human0.95515278
115WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.95232695
116RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.94557115
117KDM2B_26808549_Chip-Seq_REH_Human0.94203276
118SMAD_19615063_ChIP-ChIP_OVARY_Human0.93613110
119WT1_25993318_ChIP-Seq_PODOCYTE_Human0.93506759
120STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.93240111
121RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.92623522
122SMAD4_21741376_ChIP-Seq_HESCs_Human0.91408621
123MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.90982141
124OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.90892920
125TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.90882011
126SMAD3_21741376_ChIP-Seq_ESCs_Human0.89841144
127EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.89513649
128RXR_22108803_ChIP-Seq_LS180_Human0.89369587
129EWS_26573619_Chip-Seq_HEK293_Human0.88163879
130CBP_20019798_ChIP-Seq_JUKART_Human0.86930551

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern5.66745681
2MP0000579_abnormal_nail_morphology5.65951622
3MP0004859_abnormal_synaptic_plasticity5.47802705
4MP0003635_abnormal_synaptic_transmissio3.87381799
5MP0005275_abnormal_skin_tensile3.59268165
6MP0004270_analgesia3.48389510
7MP0009745_abnormal_behavioral_response3.27987659
8MP0002063_abnormal_learning/memory/cond3.21766907
9MP0008438_abnormal_cutaneous_collagen3.08555784
10MP0001968_abnormal_touch/_nociception2.88613056
11MP0002064_seizures2.86802938
12MP0002572_abnormal_emotion/affect_behav2.83575398
13MP0006276_abnormal_autonomic_nervous2.60462050
14MP0009046_muscle_twitch2.55579105
15MP0005423_abnormal_somatic_nervous2.54325555
16MP0001501_abnormal_sleep_pattern2.45228438
17MP0004272_abnormal_basement_membrane2.42936025
18MP0002272_abnormal_nervous_system2.41305059
19MP0002822_catalepsy2.40601844
20MP0002734_abnormal_mechanical_nocicepti2.38929242
21MP0001440_abnormal_grooming_behavior2.37048219
22MP0000778_abnormal_nervous_system2.33232371
23MP0002736_abnormal_nociception_after2.33034716
24MP0000566_synostosis2.32673809
25MP0002735_abnormal_chemical_nociception2.30830490
26MP0001486_abnormal_startle_reflex2.30455456
27MP0000762_abnormal_tongue_morphology2.26205615
28MP0001529_abnormal_vocalization2.22201811
29MP0002184_abnormal_innervation2.08970717
30MP0003705_abnormal_hypodermis_morpholog2.03693832
31MP0001188_hyperpigmentation1.93755495
32MP0002067_abnormal_sensory_capabilities1.92847844
33MP0004084_abnormal_cardiac_muscle1.90729749
34MP0001984_abnormal_olfaction1.90437685
35MP0002733_abnormal_thermal_nociception1.89688057
36MP0005503_abnormal_tendon_morphology1.83417222
37MP0000467_abnormal_esophagus_morphology1.81249865
38MP0002557_abnormal_social/conspecific_i1.80323500
39MP0001970_abnormal_pain_threshold1.80235825
40MP0001905_abnormal_dopamine_level1.78238150
41MP0004924_abnormal_behavior1.73166518
42MP0005386_behavior/neurological_phenoty1.73166518
43MP0001299_abnormal_eye_distance/1.71337215
44MP0003941_abnormal_skin_development1.69347376
45MP0001958_emphysema1.67813982
46MP0005645_abnormal_hypothalamus_physiol1.67352153
47MP0003329_amyloid_beta_deposits1.63595076
48MP0002060_abnormal_skin_morphology1.62725711
49MP0004885_abnormal_endolymph1.56018057
50MP0003122_maternal_imprinting1.55728650
51MP0005646_abnormal_pituitary_gland1.55369966
52MP0009780_abnormal_chondrocyte_physiolo1.54225054
53MP0004811_abnormal_neuron_physiology1.51246385
54MP0010368_abnormal_lymphatic_system1.49688288
55MP0009384_cardiac_valve_regurgitation1.47976341
56MP0010386_abnormal_urinary_bladder1.47536666
57MP0003566_abnormal_cell_adhesion1.46127015
58MP0002837_dystrophic_cardiac_calcinosis1.43592613
59MP0000955_abnormal_spinal_cord1.42727933
60MP0005499_abnormal_olfactory_system1.42253527
61MP0005394_taste/olfaction_phenotype1.42253527
62MP0005409_darkened_coat_color1.41446741
63MP0002882_abnormal_neuron_morphology1.39561964
64MP0003787_abnormal_imprinting1.39389520
65MP0002909_abnormal_adrenal_gland1.38420163
66MP0009053_abnormal_anal_canal1.36962883
67MP0004858_abnormal_nervous_system1.36392533
68MP0003879_abnormal_hair_cell1.35149556
69MP0009379_abnormal_foot_pigmentation1.34304914
70MP0005257_abnormal_intraocular_pressure1.33793592
71MP0002066_abnormal_motor_capabilities/c1.30600515
72MP0008569_lethality_at_weaning1.30216705
73MP0004742_abnormal_vestibular_system1.29898487
74MP0000569_abnormal_digit_pigmentation1.28722227
75MP0001502_abnormal_circadian_rhythm1.28713864
76MP0003385_abnormal_body_wall1.23987525
77MP0005623_abnormal_meninges_morphology1.22911035
78MP0002295_abnormal_pulmonary_circulatio1.21447883
79MP0000383_abnormal_hair_follicle1.16651296
80MP0001849_ear_inflammation1.12860352
81MP0002098_abnormal_vibrissa_morphology1.11696968
82MP0002152_abnormal_brain_morphology1.11206642
83MP0003755_abnormal_palate_morphology1.10397649
84MP0003279_aneurysm1.08030066
85MP0004142_abnormal_muscle_tone1.04792713
86MP0000631_abnormal_neuroendocrine_gland1.03478694
87MP0005551_abnormal_eye_electrophysiolog1.03460281
88MP0000749_muscle_degeneration1.02580778
89MP0003283_abnormal_digestive_organ1.02433672
90MP0002796_impaired_skin_barrier1.02041805
91MP0009250_abnormal_appendicular_skeleto1.01608274
92MP0005330_cardiomyopathy1.00548219
93MP0008789_abnormal_olfactory_epithelium0.99665350
94MP0003633_abnormal_nervous_system0.99202492
95MP0000534_abnormal_ureter_morphology0.97509104
96MP0010678_abnormal_skin_adnexa0.97138100
97MP0002972_abnormal_cardiac_muscle0.96143074
98MP0000751_myopathy0.95052528
99MP0004145_abnormal_muscle_electrophysio0.94748600
100MP0010771_integument_phenotype0.93439418
101MP0005620_abnormal_muscle_contractility0.91329195
102MP0003631_nervous_system_phenotype0.91309811
103MP0002638_abnormal_pupillary_reflex0.91308563
104MP0002069_abnormal_eating/drinking_beha0.91282194
105MP0001963_abnormal_hearing_physiology0.91082680
106MP0002752_abnormal_somatic_nervous0.89815153
107MP0006292_abnormal_olfactory_placode0.89329954
108MP0002229_neurodegeneration0.87637438
109MP0001879_abnormal_lymphatic_vessel0.87512455
110MP0008775_abnormal_heart_ventricle0.87244192
111MP0006138_congestive_heart_failure0.86649423
112MP0005187_abnormal_penis_morphology0.86536169
113MP0008872_abnormal_physiological_respon0.86384621
114MP0001216_abnormal_epidermal_layer0.84118861
115MP0004085_abnormal_heartbeat0.82774008
116MP0000462_abnormal_digestive_system0.82535418
117MP0010030_abnormal_orbit_morphology0.81936903
118MP0006072_abnormal_retinal_apoptosis0.81218707
119MP0005535_abnormal_body_temperature0.81046600
120MP0004036_abnormal_muscle_relaxation0.79117844
121MP0005508_abnormal_skeleton_morphology0.78729561
122MP0002102_abnormal_ear_morphology0.78094827
123MP0002876_abnormal_thyroid_physiology0.77874655
124MP0000026_abnormal_inner_ear0.76749101
125MP0004134_abnormal_chest_morphology0.76462939
126MP0000427_abnormal_hair_cycle0.73663632
127MP0004087_abnormal_muscle_fiber0.73570400
128MP0002282_abnormal_trachea_morphology0.72231206
129MP0001485_abnormal_pinna_reflex0.71978987
130MP0002234_abnormal_pharynx_morphology0.71095019
131MP0000538_abnormal_urinary_bladder0.69852682
132MP0001664_abnormal_digestion0.68633204
133MP0003632_abnormal_nervous_system0.67495996
134MP0003861_abnormal_nervous_system0.66461303
135MP0008874_decreased_physiological_sensi0.66341111
136MP0003634_abnormal_glial_cell0.65020981
137MP0004484_altered_response_of0.64648917
138MP0000604_amyloidosis0.62189757
139MP0000013_abnormal_adipose_tissue0.62157545
140MP0001177_atelectasis0.62053915
141MP0001943_abnormal_respiration0.60845556
142MP0004215_abnormal_myocardial_fiber0.60026892
143MP0003121_genomic_imprinting0.59608384
144MP0002751_abnormal_autonomic_nervous0.59367613
145MP0005379_endocrine/exocrine_gland_phen0.58663643
146MP0003137_abnormal_impulse_conducting0.57016284
147MP0002090_abnormal_vision0.56979239
148MP0003938_abnormal_ear_development0.51065760
149MP0000537_abnormal_urethra_morphology0.48853900
150MP0010770_preweaning_lethality0.48806905

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.37282751
2Atrophic scars (HP:0001075)7.19803440
3Milia (HP:0001056)6.23166831
4Fragile nails (HP:0001808)5.76785938
5Onycholysis (HP:0001806)5.52018491
6Focal seizures (HP:0007359)5.49719437
7Myokymia (HP:0002411)5.17583448
8Visual hallucinations (HP:0002367)4.95714209
9Plantar hyperkeratosis (HP:0007556)4.78136390
10Abnormality of nail color (HP:0100643)4.77491059
11Atonic seizures (HP:0010819)4.64833529
12Epileptic encephalopathy (HP:0200134)4.58681097
13Right ventricular cardiomyopathy (HP:0011663)4.42283981
14Absence seizures (HP:0002121)4.42253618
15Thick nail (HP:0001805)4.29453964
16Febrile seizures (HP:0002373)4.25298192
17Alopecia of scalp (HP:0002293)4.20604287
18Hyperventilation (HP:0002883)4.08667767
19Dialeptic seizures (HP:0011146)4.04328814
20Progressive cerebellar ataxia (HP:0002073)3.89879418
21Amblyopia (HP:0000646)3.80780643
22Generalized tonic-clonic seizures (HP:0002069)3.77620971
23Broad-based gait (HP:0002136)3.71956221
24Cerebral inclusion bodies (HP:0100314)3.63053957
25Fragile skin (HP:0001030)3.59950508
26Drooling (HP:0002307)3.41651812
27Excessive salivation (HP:0003781)3.41651812
28Supranuclear gaze palsy (HP:0000605)3.41328860
29Sudden death (HP:0001699)3.35539672
30Limb dystonia (HP:0002451)3.19133367
31Nail dystrophy (HP:0008404)3.18688886
32Neurofibrillary tangles (HP:0002185)3.17517397
33Premature rupture of membranes (HP:0001788)3.16608570
34Ridged nail (HP:0001807)3.05666466
35Palmoplantar hyperkeratosis (HP:0000972)3.03378163
36Truncal ataxia (HP:0002078)2.98533593
37Ventricular tachycardia (HP:0004756)2.93481028
38Anxiety (HP:0000739)2.90664523
39Follicular hyperkeratosis (HP:0007502)2.89239013
40Palmar hyperkeratosis (HP:0010765)2.88869500
41Hemiparesis (HP:0001269)2.78747284
42Syncope (HP:0001279)2.77276801
43Epileptiform EEG discharges (HP:0011182)2.73248359
44Polyphagia (HP:0002591)2.73173962
45Bundle branch block (HP:0011710)2.72645546
46Action tremor (HP:0002345)2.70227961
47Atrial fibrillation (HP:0005110)2.69392120
48Protrusio acetabuli (HP:0003179)2.66887381
49Poor eye contact (HP:0000817)2.66003257
50Gaze-evoked nystagmus (HP:0000640)2.62302478
51Vascular tortuosity (HP:0004948)2.59972738
52Hypoplasia of dental enamel (HP:0006297)2.53903234
53Dysmetria (HP:0001310)2.53518892
54Mutism (HP:0002300)2.52827250
55Absent speech (HP:0001344)2.52285603
56EEG with generalized epileptiform discharges (HP:0011198)2.50930211
57Impaired vibration sensation in the lower limbs (HP:0002166)2.50231831
58Abnormal eating behavior (HP:0100738)2.50114951
59Progressive inability to walk (HP:0002505)2.49751797
60Abnormality of salivation (HP:0100755)2.49452689
61Diplopia (HP:0000651)2.48990103
62Abnormality of binocular vision (HP:0011514)2.48990103
63Dysdiadochokinesis (HP:0002075)2.46481496
64Pterygium (HP:0001059)2.45494170
65Gait imbalance (HP:0002141)2.44008488
66Arterial tortuosity (HP:0005116)2.43899698
67Primary atrial arrhythmia (HP:0001692)2.43450171
68Bladder diverticulum (HP:0000015)2.42236621
69Depression (HP:0000716)2.41736877
70Exotropia (HP:0000577)2.41719069
71Ankle clonus (HP:0011448)2.41268122
72Protruding tongue (HP:0010808)2.38923679
73Fatigable weakness (HP:0003473)2.38500984
74Abnormality of the neuromuscular junction (HP:0003398)2.38500984
75Hypothermia (HP:0002045)2.34825234
76Genu recurvatum (HP:0002816)2.33467064
77Abnormality of the corticospinal tract (HP:0002492)2.32757993
78Supraventricular tachycardia (HP:0004755)2.31978229
79Urinary bladder sphincter dysfunction (HP:0002839)2.31237369
80Impaired social interactions (HP:0000735)2.31055866
81Abnormal social behavior (HP:0012433)2.31055866
82Broad metatarsal (HP:0001783)2.30605493
83Supraventricular arrhythmia (HP:0005115)2.29017178
84Hypsarrhythmia (HP:0002521)2.26753940
85Inability to walk (HP:0002540)2.25749156
86Amyotrophic lateral sclerosis (HP:0007354)2.25646557
87Agitation (HP:0000713)2.24016101
88Hypodontia (HP:0000668)2.23065336
89Shallow orbits (HP:0000586)2.19218029
90Abnormal blistering of the skin (HP:0008066)2.18728646
91Delusions (HP:0000746)2.17499701
92Hyporeflexia of lower limbs (HP:0002600)2.16732778
93Abnormality of dentin (HP:0010299)2.14989857
94Natal tooth (HP:0000695)2.14947209
95Fetal akinesia sequence (HP:0001989)2.14363825
96Impaired smooth pursuit (HP:0007772)2.13776918
97Aplasia cutis congenita (HP:0001057)2.13186186
98Termporal pattern (HP:0011008)2.13166287
99Insidious onset (HP:0003587)2.13166287
100Acute necrotizing encephalopathy (HP:0006965)2.10280620
101Aortic dissection (HP:0002647)2.08632302
102Stereotypic behavior (HP:0000733)2.07473305
103Sparse scalp hair (HP:0002209)2.05510684
104Palmoplantar keratoderma (HP:0000982)2.03788067
105Spastic gait (HP:0002064)2.00448101
106Genetic anticipation (HP:0003743)2.00016135
107Soft skin (HP:0000977)1.99062491
108Neonatal short-limb short stature (HP:0008921)1.98929665
109Progressive macrocephaly (HP:0004481)1.98065400
110Urinary urgency (HP:0000012)1.98012121
111Psychosis (HP:0000709)1.97395543
112Bradykinesia (HP:0002067)1.97371649
113Absent/shortened dynein arms (HP:0200106)1.96308010
114Dynein arm defect of respiratory motile cilia (HP:0012255)1.96308010
115Esotropia (HP:0000565)1.96075544
116Hypotrichosis (HP:0001006)1.95828109
117Hyperthyroidism (HP:0000836)1.94836263
118Medial flaring of the eyebrow (HP:0010747)1.94031910
119Morphological abnormality of the middle ear (HP:0008609)1.93859854
120Generalized myoclonic seizures (HP:0002123)1.93579337
121Coronal craniosynostosis (HP:0004440)1.92813682
122Pheochromocytoma (HP:0002666)1.92269715
123Pili torti (HP:0003777)1.90985976
124Congenital primary aphakia (HP:0007707)1.90882932
125Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.90637406
126Abnormal ciliary motility (HP:0012262)1.90438664
127Oligodontia (HP:0000677)1.89783298
128Retinal dysplasia (HP:0007973)1.89506789
129Postural instability (HP:0002172)1.88749169
130Abnormality of the calf musculature (HP:0001430)1.88682458
131Specific learning disability (HP:0001328)1.88015370
132Lipoatrophy (HP:0100578)1.87877675
133Difficulty climbing stairs (HP:0003551)1.87529600
134Ventricular arrhythmia (HP:0004308)1.87304558
135Split foot (HP:0001839)1.86407175
136Delayed gross motor development (HP:0002194)1.84436165
137Aplasia/Hypoplasia of the brainstem (HP:0007362)1.84201685
138Hypoplasia of the brainstem (HP:0002365)1.84201685
139Thickened helices (HP:0000391)1.82525560
140Blue irides (HP:0000635)1.81822349
141Sleep apnea (HP:0010535)1.81699050
142Genital tract atresia (HP:0001827)1.80534665
143Lower limb muscle weakness (HP:0007340)1.80012472
144Degeneration of the lateral corticospinal tracts (HP:0002314)1.79222303
145Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.79222303
146Papilledema (HP:0001085)1.79175178
147Heart block (HP:0012722)1.78873882
148Abnormal mitochondria in muscle tissue (HP:0008316)1.78865573
149Inappropriate behavior (HP:0000719)1.78530945
150Failure to thrive in infancy (HP:0001531)1.78490684
151Absent eyelashes (HP:0000561)1.78375196
152Hypoventilation (HP:0002791)1.78302845
153Limited hip movement (HP:0008800)1.78224601
154Nephrogenic diabetes insipidus (HP:0009806)1.78211429
155Vaginal atresia (HP:0000148)1.77751735
156Torticollis (HP:0000473)1.76963909
157Abnormality of ocular smooth pursuit (HP:0000617)1.76954603
158Hypoplastic labia majora (HP:0000059)1.76788169
159Esophageal atresia (HP:0002032)1.76619076
160Scanning speech (HP:0002168)1.75960156
161Laryngomalacia (HP:0001601)1.75872474
162Gastroesophageal reflux (HP:0002020)1.74992055
163Widely spaced teeth (HP:0000687)1.74620644
164Abnormal atrioventricular conduction (HP:0005150)1.70315620
165Vertebral arch anomaly (HP:0008438)1.69292288
166Woolly hair (HP:0002224)1.68976641
167Bradycardia (HP:0001662)1.65549185
168Labial hypoplasia (HP:0000066)1.63413275
169Prolonged QT interval (HP:0001657)1.61198417
170Overgrowth (HP:0001548)1.59606683
171Anonychia (HP:0001798)1.58312932
172Ulnar claw (HP:0001178)1.57187125
173Muscle fiber splitting (HP:0003555)1.54592073
174Atrioventricular block (HP:0001678)1.54588830
175Hammertoe (HP:0001765)1.52647878
176Selective tooth agenesis (HP:0001592)1.52261218
177Abnormality of the labia majora (HP:0012881)1.52051559
178Type 1 muscle fiber predominance (HP:0003803)1.51283690
179Hip dysplasia (HP:0001385)1.50511115
180Left ventricular hypertrophy (HP:0001712)1.50055945
181Ankle contracture (HP:0006466)1.49895685
182Tibial bowing (HP:0002982)1.49779327
183Corneal dystrophy (HP:0001131)1.49397775
184Advanced eruption of teeth (HP:0006288)1.47683973
185Aplasia involving bones of the upper limbs (HP:0009823)1.46306971
186Aplasia of the phalanges of the hand (HP:0009802)1.46306971
187Aplasia involving bones of the extremities (HP:0009825)1.46306971
188Mild short stature (HP:0003502)1.45472847

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.64344371
2EPHA44.40318232
3MARK13.77011092
4MAP3K93.32809495
5MAP3K43.18948543
6CASK2.97928962
7MAP2K72.79655371
8MAP3K122.60404771
9MYLK2.51502566
10MINK12.49992614
11PNCK2.42448426
12RIPK42.25197704
13NTRK22.21508498
14TTN2.04037585
15MAP2K41.95008743
16MAPK131.93416809
17PLK21.92257058
18TNIK1.87910981
19DAPK21.83865773
20GRK51.71009990
21DAPK11.68053858
22KSR11.61330900
23SIK11.58863543
24SIK21.58691605
25DMPK1.54481088
26NTRK11.52766781
27PINK11.42908873
28NME11.42057926
29CDK51.41146031
30ARAF1.39385334
31EPHA31.38708614
32PDGFRA1.37644014
33PAK61.35834228
34CAMK2A1.28116982
35KSR21.26923435
36BMPR21.23029246
37WNK31.22054159
38PRKCG1.21158552
39CAMK2B1.18944595
40PRPF4B1.16694021
41FGR1.15630119
42PTK21.15226956
43MET1.15063373
44UHMK11.14930541
45PIM21.14600142
46FES1.10744351
47ROCK11.09181569
48GRK71.08492606
49PTK2B1.04747042
50RIPK11.01465808
51CDK190.99526254
52DYRK1A0.99382651
53DDR20.98456128
54LATS10.98212223
55PHKG10.95526031
56PHKG20.95526031
57TGFBR10.94848432
58LIMK10.93357564
59CSNK1G20.91781705
60WNK10.83873107
61EPHB20.83098348
62CDK180.82527702
63MOS0.80428692
64MAP3K130.79736684
65BCR0.79667939
66DYRK20.78365732
67CDK150.77973451
68LATS20.77917851
69CDK140.77659057
70MST1R0.75284181
71FER0.73323352
72PRKCE0.72311497
73MAP3K20.72259339
74SIK30.72215595
75OXSR10.71562205
76PAK30.70046066
77ERBB30.69526875
78PAK20.68069312
79CDK11A0.67609306
80PDGFRB0.67479904
81PRKD10.67322062
82MAP3K60.67155661
83SGK2230.66330233
84SGK4940.66330233
85SGK10.66221904
86STK380.65879204
87NEK90.65567082
88CAMKK10.64726642
89CAMK2D0.64168425
90LMTK20.63946064
91GRK60.63907135
92STK110.60129190
93OBSCN0.59772832
94RAF10.59028598
95PRKCH0.58416290
96ADRBK10.56947326
97CSNK1G30.56627612
98TYRO30.55109982
99MARK20.54910151
100MUSK0.54286886
101STK38L0.52364139
102FLT30.52311753
103SGK20.51430249
104PRKCZ0.51318563
105PRKD30.50649794
106CAMK10.50224137
107AKT30.48739650
108BMPR1B0.48518917
109RPS6KC10.47283055
110RPS6KL10.47283055
111PKN10.45982761
112RPS6KA60.45533295
113CAMKK20.45392473
114RET0.44978760
115TNK20.44057936
116PRKAA10.42536602
117PRKD20.42298376
118PIK3CA0.42151390
119FYN0.41258762
120CAMK2G0.41238884
121ROCK20.41153207
122CAMK1G0.40257418
123TGFBR20.39913157
124MAP2K10.38396193
125PRKACA0.38279849
126MAPK120.36460690
127BRAF0.36014607
128FGFR20.35128029
129RPS6KA20.35019586
130PRKCB0.34636476
131RPS6KA30.33186928
132CSNK1E0.32529863
133PRKG10.32427871
134MAPKAPK50.32133345
135ADRBK20.31726246

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.50336253
2Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.92130566
3ECM-receptor interaction_Homo sapiens_hsa045122.91855691
4Synaptic vesicle cycle_Homo sapiens_hsa047212.89700950
5Long-term potentiation_Homo sapiens_hsa047202.83788651
6Amphetamine addiction_Homo sapiens_hsa050312.73393922
7Circadian entrainment_Homo sapiens_hsa047132.65085625
8Glutamatergic synapse_Homo sapiens_hsa047242.61672813
9GABAergic synapse_Homo sapiens_hsa047272.59768229
10Olfactory transduction_Homo sapiens_hsa047402.48968536
11Morphine addiction_Homo sapiens_hsa050322.44811837
12Dopaminergic synapse_Homo sapiens_hsa047282.34416462
13Taste transduction_Homo sapiens_hsa047422.24930836
14Salivary secretion_Homo sapiens_hsa049702.10734255
15Serotonergic synapse_Homo sapiens_hsa047262.07613663
16Renin secretion_Homo sapiens_hsa049242.00554055
17Collecting duct acid secretion_Homo sapiens_hsa049661.99879932
18Cocaine addiction_Homo sapiens_hsa050301.89105708
19Insulin secretion_Homo sapiens_hsa049111.88443692
20Cholinergic synapse_Homo sapiens_hsa047251.84357607
21Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.83065028
22Long-term depression_Homo sapiens_hsa047301.77182274
23Calcium signaling pathway_Homo sapiens_hsa040201.71823943
24Gastric acid secretion_Homo sapiens_hsa049711.69656382
25Focal adhesion_Homo sapiens_hsa045101.68275284
26Oxidative phosphorylation_Homo sapiens_hsa001901.67994817
27Aldosterone synthesis and secretion_Homo sapiens_hsa049251.64096363
28Oxytocin signaling pathway_Homo sapiens_hsa049211.57039173
29Alzheimers disease_Homo sapiens_hsa050101.55098185
30Axon guidance_Homo sapiens_hsa043601.51903493
31Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.45971100
32Phototransduction_Homo sapiens_hsa047441.45258839
33Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.42030896
34GnRH signaling pathway_Homo sapiens_hsa049121.39226667
35Cardiac muscle contraction_Homo sapiens_hsa042601.38974101
36Gap junction_Homo sapiens_hsa045401.36495035
37Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.34957325
38Parkinsons disease_Homo sapiens_hsa050121.26841109
39Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.24407219
40Vibrio cholerae infection_Homo sapiens_hsa051101.22867855
41Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.17495520
42Amoebiasis_Homo sapiens_hsa051461.17380302
43Hippo signaling pathway_Homo sapiens_hsa043901.17072159
44cAMP signaling pathway_Homo sapiens_hsa040241.16372814
45Protein digestion and absorption_Homo sapiens_hsa049741.12704704
46Melanogenesis_Homo sapiens_hsa049161.12126149
47Estrogen signaling pathway_Homo sapiens_hsa049151.08395626
48Adherens junction_Homo sapiens_hsa045201.06030553
49cGMP-PKG signaling pathway_Homo sapiens_hsa040221.01421424
50Basal cell carcinoma_Homo sapiens_hsa052171.00787029
51Phosphatidylinositol signaling system_Homo sapiens_hsa040700.98261738
52Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.96902944
53Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.95553866
54Huntingtons disease_Homo sapiens_hsa050160.93847226
55Type II diabetes mellitus_Homo sapiens_hsa049300.93268413
56Glioma_Homo sapiens_hsa052140.90346785
57Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.89986508
58Vascular smooth muscle contraction_Homo sapiens_hsa042700.88322869
59Regulation of actin cytoskeleton_Homo sapiens_hsa048100.87084938
60ErbB signaling pathway_Homo sapiens_hsa040120.85803409
61Pancreatic secretion_Homo sapiens_hsa049720.82681474
62Tight junction_Homo sapiens_hsa045300.81951345
63Small cell lung cancer_Homo sapiens_hsa052220.81420939
64Melanoma_Homo sapiens_hsa052180.81035144
65Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.80615002
66PI3K-Akt signaling pathway_Homo sapiens_hsa041510.78282888
67Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.77998126
68Proteoglycans in cancer_Homo sapiens_hsa052050.77177794
69Oocyte meiosis_Homo sapiens_hsa041140.74973623
70Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.73799237
71Steroid biosynthesis_Homo sapiens_hsa001000.72604259
72Dorso-ventral axis formation_Homo sapiens_hsa043200.68240265
73Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.67348458
74Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.63555307
75Choline metabolism in cancer_Homo sapiens_hsa052310.63412289
76Pathways in cancer_Homo sapiens_hsa052000.62776882
77MAPK signaling pathway_Homo sapiens_hsa040100.61458309
78Thyroid hormone synthesis_Homo sapiens_hsa049180.60861948
79Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.60756969
80Glucagon signaling pathway_Homo sapiens_hsa049220.60556115
81Dilated cardiomyopathy_Homo sapiens_hsa054140.60530275
82African trypanosomiasis_Homo sapiens_hsa051430.59180360
83TGF-beta signaling pathway_Homo sapiens_hsa043500.58485444
84Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.58471591
85Phospholipase D signaling pathway_Homo sapiens_hsa040720.57864927
86Alcoholism_Homo sapiens_hsa050340.57722089
87Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.57029543
88Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.55974828
89Ras signaling pathway_Homo sapiens_hsa040140.55747040
90Wnt signaling pathway_Homo sapiens_hsa043100.55090220
91Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.52537383
92VEGF signaling pathway_Homo sapiens_hsa043700.51697730
93Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.48097429
94MicroRNAs in cancer_Homo sapiens_hsa052060.47837558
95AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.46711057
96Bile secretion_Homo sapiens_hsa049760.46438717
97Prion diseases_Homo sapiens_hsa050200.45122703
98AMPK signaling pathway_Homo sapiens_hsa041520.44824620
99Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.44277834
100Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.43812658
101Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.43810620
102Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.42762346
103Rap1 signaling pathway_Homo sapiens_hsa040150.42722632
104Circadian rhythm_Homo sapiens_hsa047100.42234757
105Sphingolipid signaling pathway_Homo sapiens_hsa040710.40488216
106Central carbon metabolism in cancer_Homo sapiens_hsa052300.40221657
107Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.39525472
108Rheumatoid arthritis_Homo sapiens_hsa053230.38776741
109Neurotrophin signaling pathway_Homo sapiens_hsa047220.37514750
110Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.36857022
111Inositol phosphate metabolism_Homo sapiens_hsa005620.34090745
112Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.31580847
113Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.30402719
114Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.29578248
115Type I diabetes mellitus_Homo sapiens_hsa049400.29409879
116Carbohydrate digestion and absorption_Homo sapiens_hsa049730.28205985
117Renal cell carcinoma_Homo sapiens_hsa052110.26704825
118Phagosome_Homo sapiens_hsa041450.26027829
119Thyroid hormone signaling pathway_Homo sapiens_hsa049190.23322277
120Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.23035349
121Ovarian steroidogenesis_Homo sapiens_hsa049130.22731816
122Hedgehog signaling pathway_Homo sapiens_hsa043400.22497868
123Endometrial cancer_Homo sapiens_hsa052130.22041114
124Colorectal cancer_Homo sapiens_hsa052100.21088870
125Insulin signaling pathway_Homo sapiens_hsa049100.20928295
126SNARE interactions in vesicular transport_Homo sapiens_hsa041300.20052227
127Mineral absorption_Homo sapiens_hsa049780.16386166

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