TELO2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that functions as an S-phase checkpoint protein in the cell cycle. The protein may also play a role in DNA repair. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1response to pheromone (GO:0019236)5.24507790
2negative regulation of cell size (GO:0045792)4.69957520
3negative regulation of erythrocyte differentiation (GO:0045647)4.51400665
4mannose metabolic process (GO:0006013)4.51106174
5regulation of mammary gland epithelial cell proliferation (GO:0033599)4.43565342
6proline biosynthetic process (GO:0006561)4.24535219
7apoptotic process involved in morphogenesis (GO:0060561)4.18636337
8DNA deamination (GO:0045006)4.11459619
9peptidyl-arginine omega-N-methylation (GO:0035247)3.99912668
10regulation of translational fidelity (GO:0006450)3.99591434
113-UTR-mediated mRNA stabilization (GO:0070935)3.78675244
12intracellular estrogen receptor signaling pathway (GO:0030520)3.72200034
13spliceosomal tri-snRNP complex assembly (GO:0000244)3.67708648
14COPI coating of Golgi vesicle (GO:0048205)3.56271724
15Golgi transport vesicle coating (GO:0048200)3.56271724
16tRNA methylation (GO:0030488)3.52841979
17regulation of nuclear cell cycle DNA replication (GO:0033262)3.52816175
18activation of Rac GTPase activity (GO:0032863)3.52643959
19planar cell polarity pathway involved in neural tube closure (GO:0090179)3.50652084
20maternal placenta development (GO:0001893)3.50187187
21protein retention in ER lumen (GO:0006621)3.47928584
22adherens junction assembly (GO:0034333)3.47628845
23negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.45733291
24negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.42176237
25pentose-phosphate shunt (GO:0006098)3.41139249
26ribosomal small subunit assembly (GO:0000028)3.39029521
27telomere maintenance via semi-conservative replication (GO:0032201)3.34585582
28maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.25332920
29histone arginine methylation (GO:0034969)3.22717806
30focal adhesion assembly (GO:0048041)3.18432301
31cell-substrate adherens junction assembly (GO:0007045)3.18432301
32positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.14870349
33regulation of chromatin binding (GO:0035561)3.11142818
34semaphorin-plexin signaling pathway (GO:0071526)3.10254604
35telomere maintenance via recombination (GO:0000722)3.08854003
36peptidyl-arginine methylation (GO:0018216)3.06930723
37peptidyl-arginine N-methylation (GO:0035246)3.06930723
38DNA replication initiation (GO:0006270)3.06438323
39positive regulation of Cdc42 GTPase activity (GO:0043089)3.05900041
40negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)3.03988094
41kinetochore assembly (GO:0051382)3.03691912
42regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.02934151
43RNA stabilization (GO:0043489)2.99256978
44mRNA stabilization (GO:0048255)2.99256978
45glucose catabolic process (GO:0006007)2.97836938
46activation of MAPKKK activity (GO:0000185)2.96948310
47retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.96711521
48nucleosome disassembly (GO:0006337)2.95145067
49protein-DNA complex disassembly (GO:0032986)2.95145067
50positive regulation of histone deacetylation (GO:0031065)2.94866421
51DNA strand elongation involved in DNA replication (GO:0006271)2.94636493
52regulation of monocyte differentiation (GO:0045655)2.93730250
53ribosomal large subunit biogenesis (GO:0042273)2.92718237
54mesenchymal cell differentiation involved in kidney development (GO:0072161)2.92576997
55mesenchymal cell differentiation involved in renal system development (GO:2001012)2.92576997
56telomere maintenance via telomere lengthening (GO:0010833)2.92008166
57kinetochore organization (GO:0051383)2.90553113
58mitotic chromosome condensation (GO:0007076)2.89749256
59UV protection (GO:0009650)2.88879056
60DNA strand elongation (GO:0022616)2.88577114
61mitotic recombination (GO:0006312)2.87796740
62histone H4 deacetylation (GO:0070933)2.85110382
63protein localization to endosome (GO:0036010)2.82277797
64exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.80764382
65proline metabolic process (GO:0006560)2.80239305
66pseudouridine synthesis (GO:0001522)2.79642531
67epithelial cell differentiation involved in prostate gland development (GO:0060742)2.79461042
68regulation of mitotic spindle checkpoint (GO:1903504)2.79350151
69regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.79350151
70regulation of glucose import in response to insulin stimulus (GO:2001273)2.78313032
71DNA integration (GO:0015074)2.78153188
72CENP-A containing nucleosome assembly (GO:0034080)2.78112258
73NADPH regeneration (GO:0006740)2.78022563
74RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.77283234
75tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.77283234
76positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.76164570
77proteasome assembly (GO:0043248)2.76059522
78establishment of integrated proviral latency (GO:0075713)2.75809221
79positive regulation of cell adhesion mediated by integrin (GO:0033630)2.74850329
80ribosomal small subunit biogenesis (GO:0042274)2.74686898
81tRNA modification (GO:0006400)2.73590739
82DNA damage response, detection of DNA damage (GO:0042769)2.73178430
83developmental pigmentation (GO:0048066)2.72357375
84ribonucleoprotein complex biogenesis (GO:0022613)2.71334684
85deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.71095509
86cell-cell junction maintenance (GO:0045217)2.70559994
87regulation of type I interferon-mediated signaling pathway (GO:0060338)2.70124282
88regulation of early endosome to late endosome transport (GO:2000641)2.68305131
89regulation of NFAT protein import into nucleus (GO:0051532)2.68292639
90nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.67504849
91protein complex localization (GO:0031503)2.67151341
92negative regulation of myotube differentiation (GO:0010832)2.66087085
93termination of RNA polymerase I transcription (GO:0006363)2.65966306
94heterochromatin organization (GO:0070828)2.65811713
95GDP-mannose metabolic process (GO:0019673)2.65218406
96NIK/NF-kappaB signaling (GO:0038061)2.65003800
97DNA ligation (GO:0006266)2.64883231
98basement membrane organization (GO:0071711)2.64366426
99apoptotic process involved in development (GO:1902742)2.63473086
100ribosome biogenesis (GO:0042254)2.63403381
101activation of JUN kinase activity (GO:0007257)2.63114650
102rRNA processing (GO:0006364)2.61465048
103lymphoid progenitor cell differentiation (GO:0002320)2.61279506
104chromatin remodeling at centromere (GO:0031055)2.60718280
105nucleotide-excision repair, DNA gap filling (GO:0006297)2.59694735
106DNA synthesis involved in DNA repair (GO:0000731)2.59330705
107histone H2A acetylation (GO:0043968)2.58629984
108lymph vessel development (GO:0001945)2.58400772
109thymic T cell selection (GO:0045061)2.58301756
110rRNA metabolic process (GO:0016072)2.57929273
111cellular protein complex localization (GO:0034629)2.57619212
112glucose 6-phosphate metabolic process (GO:0051156)2.57589647
113cellular response to virus (GO:0098586)2.55394054
114modulation by virus of host process (GO:0019054)2.54522410
115transcription elongation from RNA polymerase I promoter (GO:0006362)2.54413205
116snRNA processing (GO:0016180)2.53321365
117IMP biosynthetic process (GO:0006188)2.53149015
118negative regulation of DNA-templated transcription, elongation (GO:0032785)2.52803104
119regulation of timing of cell differentiation (GO:0048505)2.52610380
120maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.52433849
121folic acid metabolic process (GO:0046655)2.51121921
122meiotic chromosome segregation (GO:0045132)2.50176330
123histone mRNA metabolic process (GO:0008334)2.49965157
124negative regulation of mRNA processing (GO:0050686)2.49661712
125centriole assembly (GO:0098534)2.49402092
126negative regulation of viral release from host cell (GO:1902187)2.48948262
127histone H3-K9 methylation (GO:0051567)2.48613479
128atrioventricular valve morphogenesis (GO:0003181)2.47593389
129pentose metabolic process (GO:0019321)2.46799084
130RNA methylation (GO:0001510)2.46419174
131positive regulation of gamma-delta T cell activation (GO:0046645)2.46350009
132mitotic G1 DNA damage checkpoint (GO:0031571)2.45972092
133transcription-coupled nucleotide-excision repair (GO:0006283)2.45905758
134telomere maintenance (GO:0000723)2.44776460
135mismatch repair (GO:0006298)2.44211675
136barbed-end actin filament capping (GO:0051016)2.44076823
137regulation of development, heterochronic (GO:0040034)2.43971396
138post-embryonic morphogenesis (GO:0009886)2.43894306
139modulation by symbiont of host cellular process (GO:0044068)2.43056764
140ncRNA processing (GO:0034470)2.42991461
141DNA replication-independent nucleosome organization (GO:0034724)2.42949306
142DNA replication-independent nucleosome assembly (GO:0006336)2.42949306
143negative regulation of mRNA metabolic process (GO:1903312)2.42615939
144deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.42486446
145telomere organization (GO:0032200)2.41678063
146cytoplasmic sequestering of transcription factor (GO:0042994)2.41444785
147amyloid precursor protein catabolic process (GO:0042987)2.41175261
148tRNA processing (GO:0008033)2.40869725
149histone H3-K4 trimethylation (GO:0080182)2.40859509
150response to muramyl dipeptide (GO:0032495)2.40697579
151stress fiber assembly (GO:0043149)2.40451489
152activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.40438649
153positive thymic T cell selection (GO:0045059)2.40314862
154peptidyl-lysine dimethylation (GO:0018027)2.40156925
155DNA strand renaturation (GO:0000733)2.38755268
156pinocytosis (GO:0006907)2.38737143
157regulation of ARF GTPase activity (GO:0032312)2.37898590
158cell-substrate junction assembly (GO:0007044)2.37570756
159DNA unwinding involved in DNA replication (GO:0006268)2.36855946
160negative regulation of DNA-dependent DNA replication (GO:2000104)2.36784848
161DNA replication checkpoint (GO:0000076)2.36599737
162positive regulation of nuclease activity (GO:0032075)2.35940819
163replicative senescence (GO:0090399)2.35043827
164viral mRNA export from host cell nucleus (GO:0046784)2.34853970
165convergent extension (GO:0060026)2.33963778
166histone H3 deacetylation (GO:0070932)2.33818816
167DNA-dependent DNA replication (GO:0006261)2.33307259
168mRNA splice site selection (GO:0006376)2.32757026
169negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.32501930
170negative regulation of cell killing (GO:0031342)2.32501930
171maturation of SSU-rRNA (GO:0030490)2.32378883
172DNA-templated transcription, termination (GO:0006353)2.30439399
173snRNA metabolic process (GO:0016073)2.29597738
174positive regulation of DNA recombination (GO:0045911)2.29326756
175positive regulation of DNA-dependent DNA replication (GO:2000105)2.27449397
176regulation of double-strand break repair via homologous recombination (GO:0010569)2.27368341
177microtubule depolymerization (GO:0007019)2.26207147
178somatic recombination of immunoglobulin gene segments (GO:0016447)2.26178169
179rRNA modification (GO:0000154)2.26164029
180spliceosomal snRNP assembly (GO:0000387)2.25945736
181somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.25480593
182isotype switching (GO:0045190)2.25480593
183somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.25480593
184positive regulation of histone H3-K4 methylation (GO:0051571)2.25327399
185regulation of non-canonical Wnt signaling pathway (GO:2000050)2.24568815
186positive regulation of developmental pigmentation (GO:0048087)2.24342150
187ncRNA metabolic process (GO:0034660)2.23248689
188deoxyribonucleotide biosynthetic process (GO:0009263)2.23233211
189spliceosomal complex assembly (GO:0000245)2.22935176
190protein K6-linked ubiquitination (GO:0085020)2.22729005
191replication fork processing (GO:0031297)2.22571032
192termination of RNA polymerase II transcription (GO:0006369)2.21934635
193pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.21018227
194transcription elongation from RNA polymerase III promoter (GO:0006385)2.20263732

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.19418247
2TP63_19390658_ChIP-ChIP_HaCaT_Human3.88094010
3CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.85690865
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.17889575
5VDR_21846776_ChIP-Seq_THP-1_Human3.17732570
6BP1_19119308_ChIP-ChIP_Hs578T_Human3.04896728
7HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.99959456
8MYC_18555785_ChIP-Seq_MESCs_Mouse2.99411320
9MYC_22102868_ChIP-Seq_BL_Human2.96354645
10NOTCH1_21737748_ChIP-Seq_TLL_Human2.92333213
11LXR_22292898_ChIP-Seq_THP-1_Human2.81451553
12KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.80213585
13ELF1_17652178_ChIP-ChIP_JURKAT_Human2.75899718
14MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.54046510
15SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.45591842
16TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.45508153
17TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.40362131
18HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.36361972
19KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.34749775
20ELK3_25401928_ChIP-Seq_HUVEC_Human2.33824440
21JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.33346697
22KDM2B_26808549_Chip-Seq_SUP-B15_Human2.31705833
23THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.24876501
24HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.14412989
25TP63_17297297_ChIP-ChIP_HaCaT_Human2.12440687
26EST1_17652178_ChIP-ChIP_JURKAT_Human2.11858027
27RACK7_27058665_Chip-Seq_MCF-7_Human2.09988165
28NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.09341669
29KDM2B_26808549_Chip-Seq_DND41_Human2.03444474
30* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.01766387
31FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.00924579
32ZNF263_19887448_ChIP-Seq_K562_Human1.98505378
33MYC_19079543_ChIP-ChIP_MESCs_Mouse1.95865027
34EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.94578594
35TCF7_22412390_ChIP-Seq_EML_Mouse1.93148775
36RBPJ_22232070_ChIP-Seq_NCS_Mouse1.91543001
37POU5F1_16153702_ChIP-ChIP_HESCs_Human1.91427997
38RARG_19884340_ChIP-ChIP_MEFs_Mouse1.88678305
39* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.86604322
40YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.85456171
41PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.84303074
42MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.82559725
43P68_20966046_ChIP-Seq_HELA_Human1.80067720
44VDR_23849224_ChIP-Seq_CD4+_Human1.75846663
45GABP_17652178_ChIP-ChIP_JURKAT_Human1.75037352
46NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.74475806
47* TET1_21451524_ChIP-Seq_MESCs_Mouse1.69906434
48FOXP3_21729870_ChIP-Seq_TREG_Human1.69246808
49DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.67626272
50NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.66101491
51CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.64948777
52ETS1_20019798_ChIP-Seq_JURKAT_Human1.64400208
53YY1_21170310_ChIP-Seq_MESCs_Mouse1.63533202
54KDM2B_26808549_Chip-Seq_K562_Human1.63040999
55ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.62927184
56FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.62131617
57CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.58966712
58THAP11_20581084_ChIP-Seq_MESCs_Mouse1.57598758
59* SA1_27219007_Chip-Seq_ERYTHROID_Human1.56243816
60ZFP281_18757296_ChIP-ChIP_E14_Mouse1.55126859
61CTCF_27219007_Chip-Seq_ERYTHROID_Human1.54858933
62IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.53000129
63SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.52985814
64KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.52544120
65VDR_24763502_ChIP-Seq_THP-1_Human1.52000271
66FOXM1_23109430_ChIP-Seq_U2OS_Human1.51961763
67* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.51735368
68ERG_21242973_ChIP-ChIP_JURKAT_Human1.51278105
69IRF1_19129219_ChIP-ChIP_H3396_Human1.51270475
70SRY_22984422_ChIP-ChIP_TESTIS_Rat1.51046343
71EGR1_19374776_ChIP-ChIP_THP-1_Human1.47216021
72MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.46663652
73MAF_26560356_Chip-Seq_TH1_Human1.45422102
74* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.44057390
75SMC4_20622854_ChIP-Seq_HELA_Human1.43663762
76E2F1_21310950_ChIP-Seq_MCF-7_Human1.43646131
77ELF1_20517297_ChIP-Seq_JURKAT_Human1.43460264
78MAF_26560356_Chip-Seq_TH2_Human1.43060935
79CIITA_25753668_ChIP-Seq_RAJI_Human1.42489009
80KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.40774642
81CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.39543589
82KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.39469718
83DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.38928703
84UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.38788830
85CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.38331585
86STAT6_21828071_ChIP-Seq_BEAS2B_Human1.36774390
87BMI1_23680149_ChIP-Seq_NPCS_Mouse1.36507341
88KDM2B_26808549_Chip-Seq_JURKAT_Human1.35811864
89SRF_21415370_ChIP-Seq_HL-1_Mouse1.34870177
90SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.34863712
91UTX_26944678_Chip-Seq_JUKART_Human1.34851851
92EWS_26573619_Chip-Seq_HEK293_Human1.34828952
93FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.34725772
94TTF2_22483619_ChIP-Seq_HELA_Human1.33297298
95PCGF2_27294783_Chip-Seq_ESCs_Mouse1.33122096
96GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.32720104
97CREB1_26743006_Chip-Seq_LNCaP_Human1.31937984
98* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.31025305
99ELK1_19687146_ChIP-ChIP_HELA_Human1.30816999
100NCOR1_26117541_ChIP-Seq_K562_Human1.27343087
101E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.26684426
102XRN2_22483619_ChIP-Seq_HELA_Human1.26237356
103SCL_19346495_ChIP-Seq_HPC-7_Human1.26220515
104KLF4_18555785_ChIP-Seq_MESCs_Mouse1.25953037
105CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.25616968
106POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.25602006
107TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.25420585
108ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.24225364
109E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.23297761
110FLI1_27457419_Chip-Seq_LIVER_Mouse1.22673171
111ZFX_18555785_ChIP-Seq_MESCs_Mouse1.22008413
112ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.21149903
113CBX2_27304074_Chip-Seq_ESCs_Mouse1.20830732
114MYC_18940864_ChIP-ChIP_HL60_Human1.20522609
115BCOR_27268052_Chip-Seq_Bcells_Human1.19898012
116ESR1_15608294_ChIP-ChIP_MCF-7_Human1.19424718
117KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.19144098
118SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.18800022
119CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.18766348
120HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.17813871
121GBX2_23144817_ChIP-Seq_PC3_Human1.17559975
122NELFA_20434984_ChIP-Seq_ESCs_Mouse1.17413149
123RUNX1_22412390_ChIP-Seq_EML_Mouse1.17268047
124BCL6_27268052_Chip-Seq_Bcells_Human1.17179911
125SOX2_16153702_ChIP-ChIP_HESCs_Human1.17166339
126RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.16434214
127EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.16270459
128NFE2_27457419_Chip-Seq_LIVER_Mouse1.15851102
129PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.14883674
130PCGF2_27294783_Chip-Seq_NPCs_Mouse1.14841573
131DCP1A_22483619_ChIP-Seq_HELA_Human1.14681760
132* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.14090914
133EZH2_22144423_ChIP-Seq_EOC_Human1.14042551
134KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.14016707
135SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.13428556
136DNAJC2_21179169_ChIP-ChIP_NT2_Human1.13200877
137P300_27058665_Chip-Seq_ZR-75-30cells_Human1.13121427
138SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.12972100
139SUZ12_27294783_Chip-Seq_NPCs_Mouse1.12695913
140KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.12413049
141ESR2_21235772_ChIP-Seq_MCF-7_Human1.11998555
142ERG_20887958_ChIP-Seq_HPC-7_Mouse1.11908843
143IGF1R_20145208_ChIP-Seq_DFB_Human1.11877625
144CTCF_26484167_Chip-Seq_Bcells_Mouse1.11810565
145BRD4_27068464_Chip-Seq_AML-cells_Mouse1.11755323
146TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.11570254
147CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.10761243
148PU.1_20513432_ChIP-Seq_Bcells_Mouse1.10714632
149SALL1_21062744_ChIP-ChIP_HESCs_Human1.10563881
150NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.10244425
151GATA1_22383799_ChIP-Seq_G1ME_Mouse1.09734478
152HOXB4_20404135_ChIP-ChIP_EML_Mouse1.09180049
153STAT3_1855785_ChIP-Seq_MESCs_Mouse1.08454679
154TP53_22127205_ChIP-Seq_IMR90_Human1.07989817
155* CTCF_27219007_Chip-Seq_Bcells_Human1.07473957
156GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.06897613
157ATF3_27146783_Chip-Seq_COLON_Human1.05651377
158ZFP57_27257070_Chip-Seq_ESCs_Mouse1.04890937
159CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.03782033
160RUNX1_27514584_Chip-Seq_MCF-7_Human1.03558655
161WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.03257864
162RARA_24833708_ChIP-Seq_LIVER_Mouse1.03150960
163RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.03080541
164SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.02367715
165MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.02331953
166FOXP1_21924763_ChIP-Seq_HESCs_Human1.01512278
167NANOG_18555785_ChIP-Seq_MESCs_Mouse1.00709469
168RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.00382439
169SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.00254213
170CTCF_21964334_Chip-Seq_Bcells_Human1.00161373
171E2F1_18555785_ChIP-Seq_MESCs_Mouse0.98172554
172SOX2_18555785_ChIP-Seq_MESCs_Mouse0.96294096
173SPI1_23547873_ChIP-Seq_NB4_Human0.95191791
174POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.95078619
175STAT4_19710469_ChIP-ChIP_TH1__Mouse0.94715620
176MYCN_18555785_ChIP-Seq_MESCs_Mouse0.92706284
177CREB1_15753290_ChIP-ChIP_HEK293T_Human0.91997585
178RNF2_27304074_Chip-Seq_NSC_Mouse0.91491497
179STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.91137109
180FUS_26573619_Chip-Seq_HEK293_Human0.90288880
181ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.87234016
182GABP_19822575_ChIP-Seq_HepG2_Human0.86238850
183CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.85924409
184LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.85124187
185EZH2_27294783_Chip-Seq_NPCs_Mouse0.82377158
186RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.82338697
187EZH2_27304074_Chip-Seq_ESCs_Mouse0.81617552
188* LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.80844971
189IRF8_22096565_ChIP-ChIP_GC-B_Human0.80150097

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003705_abnormal_hypodermis_morpholog4.40502582
2MP0009278_abnormal_bone_marrow3.76429820
3MP0006292_abnormal_olfactory_placode3.75049396
4MP0005058_abnormal_lysosome_morphology3.47490065
5MP0005076_abnormal_cell_differentiation3.23666858
6MP0001849_ear_inflammation3.07870120
7MP0008058_abnormal_DNA_repair2.98583915
8MP0008057_abnormal_DNA_replication2.72757735
9MP0008260_abnormal_autophagy2.63007019
10MP0000015_abnormal_ear_pigmentation2.54827556
11MP0010094_abnormal_chromosome_stability2.54584770
12MP0001188_hyperpigmentation2.45000893
13MP0005171_absent_coat_pigmentation2.44036139
14MP0005451_abnormal_body_composition2.39312242
15MP0004858_abnormal_nervous_system2.36834120
16MP0003111_abnormal_nucleus_morphology2.35814654
17MP0000566_synostosis2.34921012
18MP0005075_abnormal_melanosome_morpholog2.27537844
19MP0002877_abnormal_melanocyte_morpholog2.22868214
20MP0005174_abnormal_tail_pigmentation2.18626484
21MP0002938_white_spotting2.16088037
22MP0004185_abnormal_adipocyte_glucose2.13458675
23MP0003693_abnormal_embryo_hatching2.08040052
24MP0003172_abnormal_lysosome_physiology2.07176991
25MP0002132_abnormal_respiratory_system2.03962493
26MP0002396_abnormal_hematopoietic_system1.99925136
27MP0003121_genomic_imprinting1.94600627
28MP0000569_abnormal_digit_pigmentation1.94226604
29MP0003136_yellow_coat_color1.93059995
30MP0005409_darkened_coat_color1.90278812
31MP0002102_abnormal_ear_morphology1.89951358
32MP0003436_decreased_susceptibility_to1.82433759
33MP0003303_peritoneal_inflammation1.81436181
34MP0010234_abnormal_vibrissa_follicle1.79917052
35MP0000372_irregular_coat_pigmentation1.79096856
36MP0003077_abnormal_cell_cycle1.78450450
37MP0003787_abnormal_imprinting1.76718272
38MP0004381_abnormal_hair_follicle1.76691213
39MP0009840_abnormal_foam_cell1.74454209
40MP0003453_abnormal_keratinocyte_physiol1.73289047
41MP0000537_abnormal_urethra_morphology1.69666397
42MP0002095_abnormal_skin_pigmentation1.68730036
43MP0002796_impaired_skin_barrier1.68464681
44MP0003122_maternal_imprinting1.62284083
45MP0003763_abnormal_thymus_physiology1.59081241
46MP0008007_abnormal_cellular_replicative1.54895164
47MP0005501_abnormal_skin_physiology1.54148610
48MP0003786_premature_aging1.49486896
49MP0005666_abnormal_adipose_tissue1.46368703
50MP0002277_abnormal_respiratory_mucosa1.45912721
51MP0005671_abnormal_response_to1.44405337
52MP0001293_anophthalmia1.40245490
53MP0001873_stomach_inflammation1.39928567
54MP0003191_abnormal_cellular_cholesterol1.39213910
55MP0000049_abnormal_middle_ear1.38912286
56MP0005423_abnormal_somatic_nervous1.38166242
57MP0008877_abnormal_DNA_methylation1.37718095
58MP0000003_abnormal_adipose_tissue1.36815570
59MP0002249_abnormal_larynx_morphology1.36772031
60MP0003566_abnormal_cell_adhesion1.36743723
61MP0005623_abnormal_meninges_morphology1.34988631
62MP0000733_abnormal_muscle_development1.34866820
63MP0003329_amyloid_beta_deposits1.33146657
64MP0004947_skin_inflammation1.33116501
65MP0010030_abnormal_orbit_morphology1.31694112
66MP0001730_embryonic_growth_arrest1.31183446
67MP0004133_heterotaxia1.30928182
68MP0005397_hematopoietic_system_phenotyp1.29009383
69MP0001545_abnormal_hematopoietic_system1.29009383
70MP0008932_abnormal_embryonic_tissue1.27538320
71MP0005375_adipose_tissue_phenotype1.26446872
72MP0004233_abnormal_muscle_weight1.25572537
73MP0001348_abnormal_lacrimal_gland1.25252177
74MP0002638_abnormal_pupillary_reflex1.25041803
75MP0002075_abnormal_coat/hair_pigmentati1.22142157
76MP0008995_early_reproductive_senescence1.19703938
77MP0001186_pigmentation_phenotype1.19079975
78MP0009672_abnormal_birth_weight1.18538772
79MP0003279_aneurysm1.15234910
80MP0003938_abnormal_ear_development1.14367456
81MP0003091_abnormal_cell_migration1.13912358
82MP0000350_abnormal_cell_proliferation1.13591050
83MP0005621_abnormal_cell_physiology1.13234841
84MP0000371_diluted_coat_color1.12940179
85MP0000703_abnormal_thymus_morphology1.10673338
86MP0002089_abnormal_postnatal_growth/wei1.10204879
87MP0006072_abnormal_retinal_apoptosis1.10045078
88MP0002751_abnormal_autonomic_nervous1.09663832
89MP0003937_abnormal_limbs/digits/tail_de1.09426507
90MP0003890_abnormal_embryonic-extraembry1.06782914
91MP0000490_abnormal_crypts_of1.06188337
92MP0002009_preneoplasia1.04622142
93MP0005257_abnormal_intraocular_pressure1.03371644
94MP0001835_abnormal_antigen_presentation1.03119734
95MP0000751_myopathy1.02530310
96MP0009931_abnormal_skin_appearance1.01311848
97* MP0002080_prenatal_lethality0.99182786
98MP0005645_abnormal_hypothalamus_physiol0.98104898
99MP0002405_respiratory_system_inflammati0.97009610
100MP0001346_abnormal_lacrimal_gland0.96475488
101MP0004957_abnormal_blastocyst_morpholog0.96055369
102MP0009250_abnormal_appendicular_skeleto0.95738361
103MP0002060_abnormal_skin_morphology0.95013999
104MP0004808_abnormal_hematopoietic_stem0.94837484
105MP0002177_abnormal_outer_ear0.94493071
106MP0002148_abnormal_hypersensitivity_rea0.94449372
107MP0008789_abnormal_olfactory_epithelium0.94342531
108MP0001286_abnormal_eye_development0.93822971
109MP0000313_abnormal_cell_death0.93401363
110MP0009384_cardiac_valve_regurgitation0.92278572
111MP0000747_muscle_weakness0.91880261
112MP0002398_abnormal_bone_marrow0.91366046
113MP0004264_abnormal_extraembryonic_tissu0.89640792
114MP0000678_abnormal_parathyroid_gland0.89426676
115MP0010307_abnormal_tumor_latency0.89210031
116MP0003315_abnormal_perineum_morphology0.88264092
117MP0001986_abnormal_taste_sensitivity0.87189186
118MP0003880_abnormal_central_pattern0.85654399
119MP0009379_abnormal_foot_pigmentation0.85332324
120MP0000767_abnormal_smooth_muscle0.85296228
121MP0000631_abnormal_neuroendocrine_gland0.84948333
122MP0003942_abnormal_urinary_system0.84055266
123MP0002933_joint_inflammation0.83635725
124MP0005377_hearing/vestibular/ear_phenot0.82703456
125MP0003878_abnormal_ear_physiology0.82703456
126MP0010630_abnormal_cardiac_muscle0.82695192
127MP0002420_abnormal_adaptive_immunity0.82223963
128MP0000613_abnormal_salivary_gland0.82129690
129MP0005379_endocrine/exocrine_gland_phen0.81156963
130MP0001819_abnormal_immune_cell0.80700339
131MP0001216_abnormal_epidermal_layer0.80280730
132MP0002006_tumorigenesis0.80225038
133MP0000759_abnormal_skeletal_muscle0.80113454
134MP0002429_abnormal_blood_cell0.79901705
135MP0002452_abnormal_antigen_presenting0.79738135
136MP0005000_abnormal_immune_tolerance0.79381889
137MP0002163_abnormal_gland_morphology0.79275570
138MP0003300_gastrointestinal_ulcer0.78897845
139MP0000026_abnormal_inner_ear0.78645528
140MP0001800_abnormal_humoral_immune0.78470913
141MP0002254_reproductive_system_inflammat0.78463576
142MP0002722_abnormal_immune_system0.78252509
143MP0000858_altered_metastatic_potential0.77993550
144MP0005384_cellular_phenotype0.77890246
145MP0009785_altered_susceptibility_to0.77516658
146MP0002098_abnormal_vibrissa_morphology0.77244185
147MP0001672_abnormal_embryogenesis/_devel0.76815615
148MP0005380_embryogenesis_phenotype0.76815615
149MP0008438_abnormal_cutaneous_collagen0.76534871
150MP0000467_abnormal_esophagus_morphology0.75977691
151MP0002723_abnormal_immune_serum0.75816886
152MP0003984_embryonic_growth_retardation0.75801373
153MP0002116_abnormal_craniofacial_bone0.75664478
154MP0000689_abnormal_spleen_morphology0.75620635
155MP0005670_abnormal_white_adipose0.75616625
156MP0005025_abnormal_response_to0.75428424
157MP0002419_abnormal_innate_immunity0.74864783
158MP0005023_abnormal_wound_healing0.74142798
159MP0002114_abnormal_axial_skeleton0.74086011
160MP0002210_abnormal_sex_determination0.73864564
161MP0002086_abnormal_extraembryonic_tissu0.73810789
162MP0002019_abnormal_tumor_incidence0.73680422
163MP0000681_abnormal_thyroid_gland0.73510742
164MP0004134_abnormal_chest_morphology0.73058592
165MP0002109_abnormal_limb_morphology0.72745597
166MP0004510_myositis0.72306778
167MP0002932_abnormal_joint_morphology0.71310198
168MP0009333_abnormal_splenocyte_physiolog0.71155485
169MP0000716_abnormal_immune_system0.70848221
170MP0005503_abnormal_tendon_morphology0.70789150
171MP0000477_abnormal_intestine_morphology0.70335045
172MP0002998_abnormal_bone_remodeling0.69731767
173MP0003567_abnormal_fetal_cardiomyocyte0.69392076
174MP0004782_abnormal_surfactant_physiolog0.69165058
175MP0004742_abnormal_vestibular_system0.68810369
176MP0005394_taste/olfaction_phenotype0.66216835

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)5.40439097
2Chromsome breakage (HP:0040012)5.00126828
3Hyperacusis (HP:0010780)3.98841067
4Abnormality of the renal collecting system (HP:0004742)3.27511373
5Duplicated collecting system (HP:0000081)3.18728061
6Broad face (HP:0000283)3.16185581
7Ulnar bowing (HP:0003031)3.10061739
8Stridor (HP:0010307)3.01533535
9Reticulocytopenia (HP:0001896)2.90411656
10Distal lower limb amyotrophy (HP:0008944)2.83364534
11Obstructive sleep apnea (HP:0002870)2.78180348
12Renal cortical cysts (HP:0000803)2.77024351
13Meckel diverticulum (HP:0002245)2.75419746
14Broad distal phalanx of finger (HP:0009836)2.74923109
15Abnormality of the preputium (HP:0100587)2.71252261
16Cerebral aneurysm (HP:0004944)2.70885542
17Abnormality of the ileum (HP:0001549)2.64693907
18Achilles tendon contracture (HP:0001771)2.64280670
19J-shaped sella turcica (HP:0002680)2.63295725
20Aplasia/Hypoplasia of the uvula (HP:0010293)2.62859876
21Increased connective tissue (HP:0009025)2.62015615
22Long palpebral fissure (HP:0000637)2.59055529
23Patchy hypopigmentation of hair (HP:0011365)2.58103835
24White forelock (HP:0002211)2.57724621
25Disproportionate tall stature (HP:0001519)2.57478960
26Biconcave vertebral bodies (HP:0004586)2.57120923
27Nephroblastoma (Wilms tumor) (HP:0002667)2.55657984
28Microvesicular hepatic steatosis (HP:0001414)2.52867500
29Ragged-red muscle fibers (HP:0003200)2.52831830
30Clubbing of toes (HP:0100760)2.51851951
31Vertebral compression fractures (HP:0002953)2.43944251
32Abnormality of the carotid arteries (HP:0005344)2.41975999
33Abnormality of chromosome stability (HP:0003220)2.41117857
34Thin bony cortex (HP:0002753)2.40597450
35Centrally nucleated skeletal muscle fibers (HP:0003687)2.40364529
36Ectopic kidney (HP:0000086)2.40218259
37Aplastic anemia (HP:0001915)2.36103736
38Embryonal renal neoplasm (HP:0011794)2.33475467
39Protrusio acetabuli (HP:0003179)2.32643520
40Cellulitis (HP:0100658)2.32262552
41Duplication of thumb phalanx (HP:0009942)2.32250574
42Tubulointerstitial nephritis (HP:0001970)2.31050919
43Abnormality of DNA repair (HP:0003254)2.30865162
44Insomnia (HP:0100785)2.28617624
45Pointed chin (HP:0000307)2.26099783
46Distal upper limb amyotrophy (HP:0007149)2.25940095
47Upper limb amyotrophy (HP:0009129)2.25940095
48Abnormality of the thoracic spine (HP:0100711)2.24324817
49Abnormality of cells of the erythroid lineage (HP:0012130)2.23998941
50Birth length less than 3rd percentile (HP:0003561)2.23852743
51Colon cancer (HP:0003003)2.23842662
52Medulloblastoma (HP:0002885)2.23738883
53Abnormality of the Achilles tendon (HP:0005109)2.23116940
54Distal lower limb muscle weakness (HP:0009053)2.22880301
55Hypertensive crisis (HP:0100735)2.21476700
56Premature graying of hair (HP:0002216)2.20908781
57Abnormal number of incisors (HP:0011064)2.18817358
58Myopathic facies (HP:0002058)2.18662512
59Truncus arteriosus (HP:0001660)2.15553210
60Bone marrow hypocellularity (HP:0005528)2.14175843
61Reticulocytosis (HP:0001923)2.13602916
62Septo-optic dysplasia (HP:0100842)2.12983107
63Thoracic kyphosis (HP:0002942)2.11995967
64Cervical subluxation (HP:0003308)2.11811370
65Colitis (HP:0002583)2.10286146
66Premature rupture of membranes (HP:0001788)2.09661473
67Spinal cord lesions (HP:0100561)2.08417191
68Syringomyelia (HP:0003396)2.08417191
69Flat acetabular roof (HP:0003180)2.05092850
70Polygenic inheritance (HP:0010982)2.04938114
71Progressive muscle weakness (HP:0003323)2.04799205
72Severe visual impairment (HP:0001141)2.04503770
73Atelectasis (HP:0100750)2.03932828
74Metaphyseal cupping (HP:0003021)2.03907469
75Turricephaly (HP:0000262)2.03239412
76Triphalangeal thumb (HP:0001199)2.02334080
77Trismus (HP:0000211)2.01165573
78Small intestinal stenosis (HP:0012848)1.98732272
79Duodenal stenosis (HP:0100867)1.98732272
80Dysostosis multiplex (HP:0000943)1.98289900
81Mitral regurgitation (HP:0001653)1.98020988
82Pallor (HP:0000980)1.97842304
83Patellar dislocation (HP:0002999)1.97827302
84Increased cerebral lipofuscin (HP:0011813)1.97442402
85Annular pancreas (HP:0001734)1.97040213
86Type 2 muscle fiber atrophy (HP:0003554)1.96864090
87Absent thumb (HP:0009777)1.95226925
88Nuclear cataract (HP:0100018)1.94998069
89Myelodysplasia (HP:0002863)1.94872363
90Shallow orbits (HP:0000586)1.94326492
91Abnormality of the incisor (HP:0000676)1.93841735
92Seborrheic dermatitis (HP:0001051)1.92232132
93Osteomalacia (HP:0002749)1.91390003
94Prostate neoplasm (HP:0100787)1.91131984
95Difficulty climbing stairs (HP:0003551)1.90024575
96Hyperthyroidism (HP:0000836)1.89691754
97Short thumb (HP:0009778)1.89236122
98Premature skin wrinkling (HP:0100678)1.89196356
99Abnormal number of erythroid precursors (HP:0012131)1.88880147
100Hypoplasia of the fovea (HP:0007750)1.88771059
101Aplasia/Hypoplasia of the fovea (HP:0008060)1.88771059
102Abnormality of the parietal bone (HP:0002696)1.87700572
103Increased neuronal autofluorescent lipopigment (HP:0002074)1.86328115
104Congenital stationary night blindness (HP:0007642)1.86228064
105Abnormality of the fingertips (HP:0001211)1.85361840
106Generalized amyotrophy (HP:0003700)1.84700041
107Bowed forearm bones (HP:0003956)1.84525356
108Bowing of the arm (HP:0006488)1.84525356
109Genu recurvatum (HP:0002816)1.84339820
110Asplenia (HP:0001746)1.84303877
111Tracheoesophageal fistula (HP:0002575)1.83163433
112Easy fatigability (HP:0003388)1.82657694
113Hemorrhage of the eye (HP:0011885)1.82230073
114Fragile skin (HP:0001030)1.81658786
115Abnormality of the distal phalanges of the toes (HP:0010182)1.80107681
116Lower limb amyotrophy (HP:0007210)1.79581256
117True hermaphroditism (HP:0010459)1.79397706
118Aplasia cutis congenita (HP:0001057)1.78254423
119Progressive external ophthalmoplegia (HP:0000590)1.77374261
120Abnormality of the columella (HP:0009929)1.75752573
121Flattened epiphyses (HP:0003071)1.75310348
122Abnormality of incisor morphology (HP:0011063)1.75005651
123Bulbar palsy (HP:0001283)1.74134200
124Rectal prolapse (HP:0002035)1.74113096
125Lymphangioma (HP:0100764)1.72443228
126Supernumerary spleens (HP:0009799)1.71376998
127Nonimmune hydrops fetalis (HP:0001790)1.71359921
128Fibular hypoplasia (HP:0003038)1.71342551
129Congenital sensorineural hearing impairment (HP:0008527)1.71329150
130Flared metaphyses (HP:0003015)1.71273457
131Patellar aplasia (HP:0006443)1.70936824
132Abnormality of the duodenum (HP:0002246)1.70807620
133Abnormality of reticulocytes (HP:0004312)1.70308089
134Microtia (HP:0008551)1.70291410
135Increased variability in muscle fiber diameter (HP:0003557)1.70276638
136Intestinal atresia (HP:0011100)1.70227446
137Elfin facies (HP:0004428)1.69891211
138Thin ribs (HP:0000883)1.69668855
139Embryonal neoplasm (HP:0002898)1.68796317
140Emphysema (HP:0002097)1.68577055
141Gastrointestinal dysmotility (HP:0002579)1.68288682
142Cholecystitis (HP:0001082)1.68237217
143Abnormal gallbladder physiology (HP:0012438)1.68237217
144Overriding aorta (HP:0002623)1.67493524
145Abnormal lung lobation (HP:0002101)1.67040869
146Supernumerary bones of the axial skeleton (HP:0009144)1.66287967
147Severe combined immunodeficiency (HP:0004430)1.66237108
148Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.66148183
149Mediastinal lymphadenopathy (HP:0100721)1.65831646
150Spinal rigidity (HP:0003306)1.65075825
151Bell-shaped thorax (HP:0001591)1.64921062
152Trigonocephaly (HP:0000243)1.64805473
153Neuronal loss in central nervous system (HP:0002529)1.64601376
154Joint stiffness (HP:0001387)1.64255689
155Partial duplication of thumb phalanx (HP:0009944)1.64227812
156Obstructive lung disease (HP:0006536)1.63807849
157Chronic obstructive pulmonary disease (HP:0006510)1.63807849
158Abnormality of the distal phalanx of the thumb (HP:0009617)1.63677797
159Sloping forehead (HP:0000340)1.63541593
160Chronic mucocutaneous candidiasis (HP:0002728)1.63456407
161Recurrent cutaneous fungal infections (HP:0011370)1.63456407
162Increased IgE level (HP:0003212)1.62826954
163Deformed sella turcica (HP:0002681)1.62411615
164Lymphoma (HP:0002665)1.62214471
165Aplasia/Hypoplasia of the spleen (HP:0010451)1.61712769
166Abnormal hair whorl (HP:0010721)1.61678218
167Neoplasm of the oral cavity (HP:0100649)1.61437778
168Absent rod-and cone-mediated responses on ERG (HP:0007688)1.61392936
169Type I transferrin isoform profile (HP:0003642)1.60853095
170Attenuation of retinal blood vessels (HP:0007843)1.59977616
171Abnormality of skeletal muscle fiber size (HP:0012084)1.59430418
172Gastrointestinal inflammation (HP:0004386)1.59058514
173Mildly elevated creatine phosphokinase (HP:0008180)1.58609073
174Preaxial hand polydactyly (HP:0001177)1.58421067
175Abnormality of the tricuspid valve (HP:0001702)1.58185018
176Bowel incontinence (HP:0002607)1.57675522
177Renal agenesis (HP:0000104)1.57551646
178Optic nerve hypoplasia (HP:0000609)1.57550037
179T lymphocytopenia (HP:0005403)1.57512713
180Hypertriglyceridemia (HP:0002155)1.57484391
181Flat cornea (HP:0007720)1.57258167
182Pseudobulbar signs (HP:0002200)1.57222027
183Oligohydramnios (HP:0001562)1.57047060
184Pulmonary artery stenosis (HP:0004415)1.56829945
185Facial cleft (HP:0002006)1.56626516
186Recurrent pneumonia (HP:0006532)1.55608654
187Supernumerary ribs (HP:0005815)1.54704631
188Renal duplication (HP:0000075)1.53639225
189Abnormality of the prostate (HP:0008775)1.52950332
190Selective tooth agenesis (HP:0001592)1.52862336
191Muscle fiber atrophy (HP:0100295)1.52833447
192Albinism (HP:0001022)1.52821000
193Aplasia/Hypoplasia of the patella (HP:0006498)1.51406072
194Increased nuchal translucency (HP:0010880)1.50863593
195Abnormality of the renal medulla (HP:0100957)1.50354997
196Retrobulbar optic neuritis (HP:0100654)1.50328714
197Optic neuritis (HP:0100653)1.50328714
198Tented upper lip vermilion (HP:0010804)1.50139069

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB35.06514674
2SMG14.38581785
3STK163.55887108
4PRPF4B3.45234241
5ZAK3.35026640
6SIK13.15303289
7EEF2K2.92467544
8MKNK22.87465339
9MKNK12.81680293
10ICK2.59255329
11BLK2.43788212
12ERN12.39411615
13SRPK12.38826382
14TESK22.35963089
15CASK2.26248548
16TNIK2.15264052
17TXK2.14936774
18VRK12.05643573
19BUB12.05546269
20EIF2AK22.01326590
21IRAK41.96609742
22BRD41.95044823
23MAP3K111.93635714
24YES11.89125686
25CDK121.88341856
26IRAK31.84518799
27MAP3K101.76933308
28TAOK21.76621126
29TLK11.72500128
30EIF2AK11.64638041
31MAP2K31.63882007
32CDK71.62998828
33CDK81.59965153
34PKN21.58196820
35BMPR1B1.57327983
36PLK41.53905788
37ATR1.53629871
38TTN1.51351446
39CDC71.50923958
40CHEK21.39558532
41SIK31.36817344
42RIPK11.32165047
43MAP3K141.32047501
44EIF2AK31.31965210
45FGFR41.29037634
46ACVR1B1.28519820
47MAPK131.27379231
48NME11.26027802
49ADRBK21.20020947
50MARK11.19469424
51GRK11.17423491
52MST1R1.14318840
53CDK31.14089301
54WEE11.14001759
55PRKD31.09657843
56KDR1.09199162
57MAP4K11.08247106
58TESK11.07077524
59CLK11.07011497
60DYRK31.06776896
61IRAK21.06425992
62MTOR1.05651463
63STK41.05126459
64PRKD21.04583909
65TYRO31.02905845
66MAP2K21.02777407
67PINK10.99770297
68TGFBR10.98828231
69RPS6KA20.97635564
70DYRK20.97328840
71TNK20.96578988
72BTK0.96301179
73RPS6KL10.96300098
74RPS6KC10.96300098
75PTK60.95649570
76TEC0.95179695
77SIK20.94692869
78NLK0.93603081
79TBK10.93569209
80PLK10.93534685
81TAOK10.92622645
82PAK40.91305536
83IKBKB0.90120281
84MAP3K10.87778167
85MUSK0.87364192
86CDK40.86269057
87NEK60.84341655
88ARAF0.83360963
89BMX0.83210813
90MAP3K30.82583438
91KSR20.82058964
92VRK20.81723653
93PDGFRA0.81567315
94CSNK1A1L0.78515291
95RPS6KB20.78062097
96HIPK20.77640007
97IRAK10.77232799
98MAP3K70.75477219
99MAP3K130.75057295
100KIT0.73465649
101LYN0.73197547
102RPS6KA60.72884973
103MAPK110.72715500
104PLK30.71486460
105MAP3K80.71144501
106GRK60.70793503
107PASK0.70739038
108CHEK10.70148785
109TSSK60.68737617
110ATM0.67824609
111NTRK30.67263934
112LRRK20.67109726
113FES0.66932123
114GRK70.66590921
115AURKB0.65903808
116TYK20.64849401
117PDPK10.64202060
118RIPK40.62351343
119RPS6KA50.62287718
120AURKA0.62096234
121CHUK0.61115139
122DYRK1B0.60965617
123SCYL20.60757844
124LCK0.60339125
125NEK20.59242850
126CCNB10.57223507
127TTK0.56878214
128RPS6KA40.56790731
129CDC42BPA0.56644936
130PIM10.56624339
131PIM20.54727748
132NUAK10.53595946
133MAP3K60.51878151
134NME20.50916033
135MAP2K70.50865098
136MAPKAPK30.50831872
137MAP3K90.50663732
138DAPK10.50436371
139AKT30.50211099
140JAK30.48206477
141BRAF0.47845620
142PTK20.47210874
143SYK0.46499382
144EPHB10.45504657
145CAMKK10.44779285
146CDK10.44651169
147CDK20.44552234
148MARK20.44388682
149IKBKE0.43907675
150CDK60.43842065
151RPS6KB10.43518215
152CSNK2A20.42844374
153* CSNK2A10.41535961
154PBK0.41499946
155DDR20.41085527
156UHMK10.40924753
157ILK0.40737232
158MAPK150.40429257
159RPS6KA10.39533975
160MAP3K120.38421108
161EPHA20.38375875
162LMTK20.37880554
163MAPK120.37863561
164CAMK10.37431520
165PKN10.37407642
166MOS0.37215407
167MAPKAPK20.37093103
168PRKDC0.37009995
169AKT20.35858239
170CDK90.35540751
171MAPK140.35290064
172MAP2K60.34565272
173CSK0.32109317
174CDK11A0.31561906
175ZAP700.30646058

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.33735740
2Mismatch repair_Homo sapiens_hsa034303.20841668
3* Fanconi anemia pathway_Homo sapiens_hsa034602.87449691
4Homologous recombination_Homo sapiens_hsa034402.84092976
5RNA polymerase_Homo sapiens_hsa030202.73754768
6Sulfur relay system_Homo sapiens_hsa041222.66028221
7Ribosome_Homo sapiens_hsa030102.62196906
8Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.51943781
9Spliceosome_Homo sapiens_hsa030402.40191451
10Cyanoamino acid metabolism_Homo sapiens_hsa004602.34127075
11Base excision repair_Homo sapiens_hsa034102.26952325
12Non-homologous end-joining_Homo sapiens_hsa034502.19884181
13Chronic myeloid leukemia_Homo sapiens_hsa052202.12668615
14Pentose phosphate pathway_Homo sapiens_hsa000302.08081167
15Fructose and mannose metabolism_Homo sapiens_hsa000512.06164299
16Nucleotide excision repair_Homo sapiens_hsa034201.95179088
17Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.93481474
18Bladder cancer_Homo sapiens_hsa052191.93375948
19Pyrimidine metabolism_Homo sapiens_hsa002401.89807085
20Central carbon metabolism in cancer_Homo sapiens_hsa052301.88265953
21Primary immunodeficiency_Homo sapiens_hsa053401.87358282
22Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.80058790
23Cell cycle_Homo sapiens_hsa041101.79726231
24Non-small cell lung cancer_Homo sapiens_hsa052231.72470847
25Biosynthesis of amino acids_Homo sapiens_hsa012301.72269434
26VEGF signaling pathway_Homo sapiens_hsa043701.69708624
27RNA degradation_Homo sapiens_hsa030181.69588458
28One carbon pool by folate_Homo sapiens_hsa006701.62147821
29Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.61561147
30Basal transcription factors_Homo sapiens_hsa030221.61028305
31Galactose metabolism_Homo sapiens_hsa000521.55952657
32RNA transport_Homo sapiens_hsa030131.54877420
33Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.49033060
34Pancreatic cancer_Homo sapiens_hsa052121.46411762
35Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.46236793
36Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.43526579
37Glycosaminoglycan degradation_Homo sapiens_hsa005311.41775641
38mRNA surveillance pathway_Homo sapiens_hsa030151.39022535
39Prion diseases_Homo sapiens_hsa050201.37428699
40NF-kappa B signaling pathway_Homo sapiens_hsa040641.36199077
41Allograft rejection_Homo sapiens_hsa053301.29783589
42Graft-versus-host disease_Homo sapiens_hsa053321.29721207
43Proteasome_Homo sapiens_hsa030501.25830640
44Endometrial cancer_Homo sapiens_hsa052131.25596839
45Herpes simplex infection_Homo sapiens_hsa051681.23640954
46Purine metabolism_Homo sapiens_hsa002301.23509274
47Hematopoietic cell lineage_Homo sapiens_hsa046401.21982084
48Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.18627438
49Neurotrophin signaling pathway_Homo sapiens_hsa047221.18540612
50Thyroid cancer_Homo sapiens_hsa052161.16953135
51Measles_Homo sapiens_hsa051621.15299308
52Transcriptional misregulation in cancer_Homo sapiens_hsa052021.14590451
53Systemic lupus erythematosus_Homo sapiens_hsa053221.13969173
542-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.10952013
55Thyroid hormone signaling pathway_Homo sapiens_hsa049191.07879156
56mTOR signaling pathway_Homo sapiens_hsa041501.06748193
57Insulin signaling pathway_Homo sapiens_hsa049101.05719475
58p53 signaling pathway_Homo sapiens_hsa041151.02762366
59Longevity regulating pathway - mammal_Homo sapiens_hsa042111.01475879
60Glioma_Homo sapiens_hsa052140.99825203
61AMPK signaling pathway_Homo sapiens_hsa041520.99357362
62Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.99170418
63Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.98773673
64Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.96790137
65Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.95386578
66ErbB signaling pathway_Homo sapiens_hsa040120.94559823
67Lysine degradation_Homo sapiens_hsa003100.93108606
68Carbon metabolism_Homo sapiens_hsa012000.92681754
69Phototransduction_Homo sapiens_hsa047440.92325092
70Hepatitis C_Homo sapiens_hsa051600.92054549
71Intestinal immune network for IgA production_Homo sapiens_hsa046720.90158279
72Phospholipase D signaling pathway_Homo sapiens_hsa040720.89491018
73Autoimmune thyroid disease_Homo sapiens_hsa053200.88876882
74Choline metabolism in cancer_Homo sapiens_hsa052310.86699282
75Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.86090391
76Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.83711971
77Basal cell carcinoma_Homo sapiens_hsa052170.83444699
78AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.83325190
79Renal cell carcinoma_Homo sapiens_hsa052110.82906505
80Epstein-Barr virus infection_Homo sapiens_hsa051690.82702411
81Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.82701832
82Nicotine addiction_Homo sapiens_hsa050330.81842426
83Lysosome_Homo sapiens_hsa041420.81013589
84GnRH signaling pathway_Homo sapiens_hsa049120.80723557
85Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.79340982
86Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.78765077
87Leukocyte transendothelial migration_Homo sapiens_hsa046700.77915083
88Leishmaniasis_Homo sapiens_hsa051400.77903832
89Other glycan degradation_Homo sapiens_hsa005110.75615326
90Asthma_Homo sapiens_hsa053100.75528638
91Type I diabetes mellitus_Homo sapiens_hsa049400.75487382
92HTLV-I infection_Homo sapiens_hsa051660.71263681
93Protein export_Homo sapiens_hsa030600.70740392
94Endocytosis_Homo sapiens_hsa041440.70541627
95Adipocytokine signaling pathway_Homo sapiens_hsa049200.70096224
96RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.68175036
97Wnt signaling pathway_Homo sapiens_hsa043100.67810500
98Prolactin signaling pathway_Homo sapiens_hsa049170.67639472
99Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.66656638
100Sphingolipid signaling pathway_Homo sapiens_hsa040710.66591223
101SNARE interactions in vesicular transport_Homo sapiens_hsa041300.66564102
102Inositol phosphate metabolism_Homo sapiens_hsa005620.65032971
103Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.64646813
104Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.63986925
105Focal adhesion_Homo sapiens_hsa045100.63749737
106NOD-like receptor signaling pathway_Homo sapiens_hsa046210.62375011
107Malaria_Homo sapiens_hsa051440.62374830
108Toxoplasmosis_Homo sapiens_hsa051450.62364158
109Estrogen signaling pathway_Homo sapiens_hsa049150.61456407
110Alcoholism_Homo sapiens_hsa050340.61099136
111Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.60045099
112T cell receptor signaling pathway_Homo sapiens_hsa046600.59450997
113Proteoglycans in cancer_Homo sapiens_hsa052050.59002068
114Toll-like receptor signaling pathway_Homo sapiens_hsa046200.58984544
115Hepatitis B_Homo sapiens_hsa051610.58140169
116Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.57836733
117Jak-STAT signaling pathway_Homo sapiens_hsa046300.57757566
118Influenza A_Homo sapiens_hsa051640.57700983
119Hedgehog signaling pathway_Homo sapiens_hsa043400.56986459
120MicroRNAs in cancer_Homo sapiens_hsa052060.56911817
121Notch signaling pathway_Homo sapiens_hsa043300.56876025
122Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.56649950
123HIF-1 signaling pathway_Homo sapiens_hsa040660.56323764
124Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.55967993
125Phosphatidylinositol signaling system_Homo sapiens_hsa040700.54571355
126Viral carcinogenesis_Homo sapiens_hsa052030.52923722
127Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.52815717
128Glycerophospholipid metabolism_Homo sapiens_hsa005640.52439688
129Salmonella infection_Homo sapiens_hsa051320.51361195
130Amoebiasis_Homo sapiens_hsa051460.51269412
131Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.50507756
132Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.48836197
133Sphingolipid metabolism_Homo sapiens_hsa006000.48395299
134Insulin resistance_Homo sapiens_hsa049310.47176317
135Rheumatoid arthritis_Homo sapiens_hsa053230.45720460
136Chemokine signaling pathway_Homo sapiens_hsa040620.45634063
137Axon guidance_Homo sapiens_hsa043600.44263403
138B cell receptor signaling pathway_Homo sapiens_hsa046620.43173480
139Arachidonic acid metabolism_Homo sapiens_hsa005900.41830065
140Apoptosis_Homo sapiens_hsa042100.41701493
141Taste transduction_Homo sapiens_hsa047420.41608093
142Legionellosis_Homo sapiens_hsa051340.41371657
143Melanoma_Homo sapiens_hsa052180.41256772
144Pathways in cancer_Homo sapiens_hsa052000.39952349
145Osteoclast differentiation_Homo sapiens_hsa043800.39452897
146Colorectal cancer_Homo sapiens_hsa052100.38989965
147Acute myeloid leukemia_Homo sapiens_hsa052210.38633828
148Small cell lung cancer_Homo sapiens_hsa052220.36167186
149Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.33540872
150Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.31817676
151Prostate cancer_Homo sapiens_hsa052150.31676160
152Viral myocarditis_Homo sapiens_hsa054160.31350505
153Antigen processing and presentation_Homo sapiens_hsa046120.30510239
154Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.30502209
155N-Glycan biosynthesis_Homo sapiens_hsa005100.30245483
156Morphine addiction_Homo sapiens_hsa050320.29623836
157Pertussis_Homo sapiens_hsa051330.29426332
158TNF signaling pathway_Homo sapiens_hsa046680.28984299
159Shigellosis_Homo sapiens_hsa051310.27906637
160Serotonergic synapse_Homo sapiens_hsa047260.27884962
161Tuberculosis_Homo sapiens_hsa051520.26690284

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