TEKT4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1motile cilium assembly (GO:0044458)9.87779362
2cilium movement (GO:0003341)9.69595955
3reproduction (GO:0000003)9.34941124
4spermatid development (GO:0007286)9.32275036
5regulation of cilium movement (GO:0003352)8.54962257
6epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)8.31868975
7primary alcohol catabolic process (GO:0034310)7.89058351
8single fertilization (GO:0007338)7.41503779
9piRNA metabolic process (GO:0034587)7.38626362
10male meiosis (GO:0007140)7.37301277
11sperm capacitation (GO:0048240)7.21891282
12synaptonemal complex organization (GO:0070193)7.10218414
13vitamin transmembrane transport (GO:0035461)7.01824128
14synaptonemal complex assembly (GO:0007130)6.87529591
15ethanol metabolic process (GO:0006067)6.75077241
16negative regulation of inclusion body assembly (GO:0090084)6.69328151
17spermatogenesis (GO:0007283)6.35172723
18male gamete generation (GO:0048232)6.32664091
19fertilization (GO:0009566)6.23762828
20ventricular system development (GO:0021591)6.22344654
21diterpenoid biosynthetic process (GO:0016102)6.12324546
22microtubule bundle formation (GO:0001578)6.11094144
23organic cation transport (GO:0015695)6.07682333
24gamete generation (GO:0007276)5.83641717
25microtubule depolymerization (GO:0007019)5.78521028
26regulation of inclusion body assembly (GO:0090083)5.61508130
27tolerance induction (GO:0002507)5.54275413
28pyrimidine-containing compound transmembrane transport (GO:0072531)5.41355480
29one-carbon compound transport (GO:0019755)5.34720028
30cellular process involved in reproduction in multicellular organism (GO:0022412)5.24457915
31calcium ion-dependent exocytosis (GO:0017156)5.23272340
32germ cell development (GO:0007281)5.23157001
33response to xenobiotic stimulus (GO:0009410)5.21810208
34microtubule severing (GO:0051013)5.18610369
35lung epithelium development (GO:0060428)5.12405313
36cell recognition (GO:0008037)5.08080210
37regulation of microtubule-based movement (GO:0060632)5.05345691
38ethanol oxidation (GO:0006069)5.04470728
39spermatid nucleus differentiation (GO:0007289)4.98917990
40negative regulation of B cell mediated immunity (GO:0002713)4.97676878
41negative regulation of immunoglobulin mediated immune response (GO:0002890)4.97676878
42negative regulation of humoral immune response (GO:0002921)4.96435043
43male meiosis I (GO:0007141)4.85617043
44regulation of germinal center formation (GO:0002634)4.84134338
45negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)4.78310500
46DNA methylation involved in gamete generation (GO:0043046)4.74987020
47establishment of apical/basal cell polarity (GO:0035089)4.74865225
48negative regulation of T cell differentiation in thymus (GO:0033085)4.68053357
49chromosome organization involved in meiosis (GO:0070192)4.66129897
50multicellular organismal reproductive process (GO:0048609)4.59463742
51glomerular epithelial cell development (GO:0072310)4.44187543
52left/right pattern formation (GO:0060972)4.39303649
53chromosome condensation (GO:0030261)4.30735219
54seminiferous tubule development (GO:0072520)4.29285325
55terpenoid biosynthetic process (GO:0016114)4.28806331
56axoneme assembly (GO:0035082)4.28568809
57positive regulation of tolerance induction (GO:0002645)4.27897213
58glycerol ether metabolic process (GO:0006662)4.21911660
59regulation of interleukin-5 production (GO:0032674)4.21685436
60meiotic nuclear division (GO:0007126)4.18803810
61DNA packaging (GO:0006323)4.09902007
62cell projection assembly (GO:0030031)4.01263368
63GTP biosynthetic process (GO:0006183)3.98514406
64nucleoside diphosphate phosphorylation (GO:0006165)3.97823671
65establishment of monopolar cell polarity (GO:0061162)3.95626279
66establishment or maintenance of monopolar cell polarity (GO:0061339)3.95626279
67regulation of interleukin-13 production (GO:0032656)3.92942895
68retinoic acid metabolic process (GO:0042573)3.90478727
69ether metabolic process (GO:0018904)3.90431233
70chaperone-mediated protein complex assembly (GO:0051131)3.90066675
71protein polyglutamylation (GO:0018095)3.86343827
72meiosis I (GO:0007127)3.83822026
73multicellular organismal development (GO:0007275)3.64975319
74exogenous drug catabolic process (GO:0042738)3.63250906
75intraciliary transport (GO:0042073)3.61270598
76protein localization to cilium (GO:0061512)3.60455350
77meiotic cell cycle (GO:0051321)3.57027138
78primary alcohol metabolic process (GO:0034308)3.54167811
79glutathione derivative metabolic process (GO:1901685)3.54110550
80glutathione derivative biosynthetic process (GO:1901687)3.54110550
81UTP biosynthetic process (GO:0006228)3.52796775
82cytoplasmic microtubule organization (GO:0031122)3.52553862
83cilium organization (GO:0044782)3.46253995
84hydrogen peroxide biosynthetic process (GO:0050665)3.45118495
85sexual reproduction (GO:0019953)3.43879204
86regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.43210320
87genitalia morphogenesis (GO:0035112)3.37124888
88cilium assembly (GO:0042384)3.29573124
89protein K11-linked deubiquitination (GO:0035871)3.29385517
90monoubiquitinated protein deubiquitination (GO:0035520)3.26584491
91regulation of tolerance induction (GO:0002643)3.25879612
92cilium morphogenesis (GO:0060271)3.25661568
93single strand break repair (GO:0000012)3.25149760
94microtubule-based movement (GO:0007018)3.24708557
95UTP metabolic process (GO:0046051)3.21761291
96retinol metabolic process (GO:0042572)3.20907274
97cellular component assembly involved in morphogenesis (GO:0010927)3.19683170
98oligosaccharide biosynthetic process (GO:0009312)3.14598623
99O-glycan processing (GO:0016266)3.12874039
100aldehyde catabolic process (GO:0046185)3.09803714
101amino-acid betaine transport (GO:0015838)3.09284753
102carnitine transport (GO:0015879)3.09284753
103regulation of autophagic vacuole assembly (GO:2000785)3.05594591
104reactive oxygen species biosynthetic process (GO:1903409)3.02974773
105multicellular organismal water homeostasis (GO:0050891)3.01579193
106drug catabolic process (GO:0042737)2.99934988
107carnitine transmembrane transport (GO:1902603)2.98463283
108regulation of spindle checkpoint (GO:0090231)2.96886725
109protein refolding (GO:0042026)2.96318231
110regulation of response to osmotic stress (GO:0047484)2.94261002
111positive regulation of macrophage activation (GO:0043032)2.93567826
112sequestering of actin monomers (GO:0042989)2.93259458
113positive regulation of smoothened signaling pathway (GO:0045880)2.92998878
114progesterone metabolic process (GO:0042448)2.91931051
115microtubule polymerization or depolymerization (GO:0031109)2.91198232
116glycolytic process (GO:0006096)2.85890732
117lateral ventricle development (GO:0021670)2.82601456
118centriole assembly (GO:0098534)2.82529545
119alditol metabolic process (GO:0019400)2.81916976
120carnitine metabolic process (GO:0009437)2.81216668
121regulation of microtubule depolymerization (GO:0031114)2.74220660
122synapsis (GO:0007129)2.72740363
123left/right axis specification (GO:0070986)2.70883455
124phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.70765262
125L-ascorbic acid metabolic process (GO:0019852)2.70360048
126hypotonic response (GO:0006971)2.70186461
127meiotic cell cycle process (GO:1903046)2.68107210
128guanosine-containing compound biosynthetic process (GO:1901070)2.67111299
129establishment of planar polarity (GO:0001736)2.66883794
130establishment of tissue polarity (GO:0007164)2.66883794
131regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator 2.65703147
132hydrogen peroxide catabolic process (GO:0042744)2.65415915
133polyol catabolic process (GO:0046174)2.65086833
134nucleus organization (GO:0006997)2.64640337
135negative regulation of organelle assembly (GO:1902116)2.62751226
136water homeostasis (GO:0030104)2.59234616
137CTP biosynthetic process (GO:0006241)2.58677889
138CTP metabolic process (GO:0046036)2.58677889
139phosphatidylcholine biosynthetic process (GO:0006656)2.58249267
140excretion (GO:0007588)2.57984194
141interferon-gamma secretion (GO:0072643)2.57944579
142regulation of toll-like receptor 4 signaling pathway (GO:0034143)2.57708472
143lactate metabolic process (GO:0006089)2.55869809
144regulation of vacuole organization (GO:0044088)2.54900208
145microtubule-based process (GO:0007017)2.54097538
146peptidyl-glutamic acid modification (GO:0018200)2.52015239
147gas transport (GO:0015669)2.52003459
148glutathione metabolic process (GO:0006749)2.51726732
149regulation of interleukin-6 biosynthetic process (GO:0045408)2.50940709
150retinal rod cell development (GO:0046548)2.49919354
151regulation of apoptotic cell clearance (GO:2000425)2.49829125
152centriole replication (GO:0007099)2.49287850
153gene silencing by RNA (GO:0031047)2.47503924
154organelle assembly (GO:0070925)2.45500017
155determination of left/right symmetry (GO:0007368)2.45394328
156iron ion import (GO:0097286)2.43044005
157hydrogen peroxide metabolic process (GO:0042743)2.41729198
158glutathione biosynthetic process (GO:0006750)2.41284672
159neurotransmitter biosynthetic process (GO:0042136)2.40626200
160fusion of sperm to egg plasma membrane (GO:0007342)13.1599852
161cell wall macromolecule catabolic process (GO:0016998)12.9736512
162cell wall macromolecule metabolic process (GO:0044036)12.9736512
163sperm motility (GO:0030317)12.9409101
164acrosome assembly (GO:0001675)12.0054482
165sperm-egg recognition (GO:0035036)11.4970500
166acrosome reaction (GO:0007340)11.4207101
167cilium or flagellum-dependent cell motility (GO:0001539)11.3871052
168axonemal dynein complex assembly (GO:0070286)11.0979956
169multicellular organism reproduction (GO:0032504)11.0381595
170epithelial cilium movement (GO:0003351)10.7432220
171binding of sperm to zona pellucida (GO:0007339)10.3378157
172cell-cell recognition (GO:0009988)10.3131078
173plasma membrane fusion (GO:0045026)10.0241883

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse8.76498205
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat5.85975731
3TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.78067456
4EZH2_22144423_ChIP-Seq_EOC_Human4.38141673
5TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.40387732
6BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.28334657
7FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human2.97823339
8GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.92176848
9DROSHA_22980978_ChIP-Seq_HELA_Human2.87665356
10PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.63955455
11ESR1_20079471_ChIP-ChIP_T-47D_Human2.58377612
12VDR_22108803_ChIP-Seq_LS180_Human2.52009257
13TRIM28_21343339_ChIP-Seq_HEK293_Human2.43450311
14CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.37164601
15CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.30726349
16SMC4_20622854_ChIP-Seq_HELA_Human2.27880792
17FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.20827295
18ELF1_20517297_ChIP-Seq_JURKAT_Human2.13881193
19STAT6_21828071_ChIP-Seq_BEAS2B_Human2.13844035
20FLI1_27457419_Chip-Seq_LIVER_Mouse2.11875435
21STAT1_20625510_ChIP-Seq_HELA_Human2.10881847
22GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.05910114
23ZNF263_19887448_ChIP-Seq_K562_Human2.03848953
24ESR2_21235772_ChIP-Seq_MCF-7_Human2.03586212
25EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human2.02992481
26RUNX1_27514584_Chip-Seq_MCF-7_Human2.02673141
27ZNF274_21170338_ChIP-Seq_K562_Hela2.01693453
28GATA1_26923725_Chip-Seq_HPCs_Mouse1.98191878
29* CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.94231142
30ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.91896444
31PCGF2_27294783_Chip-Seq_ESCs_Mouse1.89681480
32TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.88308791
33KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.88223759
34GATA1_19941826_ChIP-Seq_K562_Human1.86829054
35CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.82646266
36ESR1_21235772_ChIP-Seq_MCF-7_Human1.78651792
37FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.78124730
38TP63_22573176_ChIP-Seq_HFKS_Human1.76268615
39SOX2_27498859_Chip-Seq_STOMACH_Mouse1.76100071
40P68_20966046_ChIP-Seq_HELA_Human1.75341979
41TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.74808439
42ELK4_26923725_Chip-Seq_MESODERM_Mouse1.74726373
43CBX2_27304074_Chip-Seq_ESCs_Mouse1.73693320
44SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.73171650
45LXR_22292898_ChIP-Seq_THP-1_Human1.66096308
46YY1_22570637_ChIP-Seq_MALME-3M_Human1.65344412
47STAT1_17558387_ChIP-Seq_HELA_Human1.65045373
48MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.64350487
49CTCF_20526341_ChIP-Seq_ESCs_Human1.61917773
50P63_26484246_Chip-Seq_KERATINOCYTES_Human1.60335430
51RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.59103914
52KAP1_22055183_ChIP-Seq_ESCs_Mouse1.54437961
53RACK7_27058665_Chip-Seq_MCF-7_Human1.52620013
54CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.52292374
55PHF8_20622854_ChIP-Seq_HELA_Human1.51339527
56FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.51275581
57GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.50877544
58TAL1_26923725_Chip-Seq_HPCs_Mouse1.50329307
59SOX2_22085726_ChIP-Seq_NPCs_Mouse1.49918644
60IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.49151450
61CBP_20019798_ChIP-Seq_JUKART_Human1.49151450
62KDM2B_26808549_Chip-Seq_REH_Human1.47561774
63WDR5_24793694_ChIP-Seq_LNCAP_Human1.47532601
64KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.47473721
65ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.45446043
66CTBP2_25329375_ChIP-Seq_LNCAP_Human1.44802812
67STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.44524894
68TDRD3_21172665_ChIP-Seq_MCF-7_Human1.44171603
69PCGF2_27294783_Chip-Seq_NPCs_Mouse1.43484235
70* GATA3_21867929_ChIP-Seq_CD8_Mouse1.43240063
71AHR_22903824_ChIP-Seq_MCF-7_Human1.42771795
72NFE2_27457419_Chip-Seq_LIVER_Mouse1.40262181
73P300_27268052_Chip-Seq_Bcells_Human1.40244366
74KLF5_25053715_ChIP-Seq_YYC3_Human1.39181076
75TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.38030791
76SOX2_20726797_ChIP-Seq_SW620_Human1.37258023
77CTCF_27219007_Chip-Seq_Bcells_Human1.37055157
78ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.36887208
79REST_21632747_ChIP-Seq_MESCs_Mouse1.36176817
80AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.35884288
81SUZ12_27294783_Chip-Seq_NPCs_Mouse1.35195744
82FLI1_21867929_ChIP-Seq_TH2_Mouse1.31099473
83E2F1_20622854_ChIP-Seq_HELA_Human1.30655072
84PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.30116870
85LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.29538313
86TP63_23658742_ChIP-Seq_EP156T_Human1.28528582
87* SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.28324371
88BCOR_27268052_Chip-Seq_Bcells_Human1.27842475
89ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.27696783
90TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.26314346
91POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.26314346
92CREB1_26743006_Chip-Seq_LNCaP_Human1.26071799
93TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.25247127
94BCL6_27268052_Chip-Seq_Bcells_Human1.25044957
95NANOG_18555785_Chip-Seq_ESCs_Mouse1.23318718
96GATA2_19941826_ChIP-Seq_K562_Human1.23228419
97SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.23219828
98P53_21459846_ChIP-Seq_SAOS-2_Human1.22874131
99RNF2_27304074_Chip-Seq_NSC_Mouse1.22695850
100CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.21653429
101GF1_26923725_Chip-Seq_HPCs_Mouse1.21462069
102CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.20769891
103CDX2_20551321_ChIP-Seq_CACO-2_Human1.20753079
104KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.20405499
105CRX_20693478_ChIP-Seq_RETINA_Mouse1.18932487
106FOXA1_25552417_ChIP-Seq_VCAP_Human1.18880394
107* GATA3_21867929_ChIP-Seq_TH1_Mouse1.18804918
108HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.17911733
109HNFA_21074721_ChIP-Seq_CACO-2_Human1.17907700
110ZFP57_27257070_Chip-Seq_ESCs_Mouse1.17496163
111PHF8_20622853_ChIP-Seq_HELA_Human1.17334452
112SMRT_27268052_Chip-Seq_Bcells_Human1.15950263
113SOX9_24532713_ChIP-Seq_HFSC_Mouse1.15346814
114SA1_27219007_Chip-Seq_ERYTHROID_Human1.15311244
115FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.15175197
116OCT4_18555785_Chip-Seq_ESCs_Mouse1.14942519
117CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.13721898
118RXR_22158963_ChIP-Seq_LIVER_Mouse1.13613477
119GATA4_25053715_ChIP-Seq_YYC3_Human1.13506506
120ARNT_22903824_ChIP-Seq_MCF-7_Human1.12883246
121EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.12771660
122* RAD21_21589869_ChIP-Seq_MESCs_Mouse1.12413466
123GATA3_24758297_ChIP-Seq_MCF-7_Human1.11996789
124FOXM1_26456572_ChIP-Seq_MCF-7_Human1.11656730
125IRF8_22096565_ChIP-ChIP_GC-B_Human1.10846950
126SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.10434548
127CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.10233208
128P53_22387025_ChIP-Seq_ESCs_Mouse1.10068607
129* ETV1_20927104_ChIP-Seq_GIST48_Human1.09728351
130FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.09482984
131MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.08774522
132RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.07751011
133GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.07721622
134SPI1_20517297_ChIP-Seq_HL60_Human1.07270019
135PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.06358933
136MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.05862207
137LXR_22158963_ChIP-Seq_LIVER_Mouse1.05350261
138ERG_20517297_ChIP-Seq_VCAP_Human1.05312084
139RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.05121044
140EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.04970569
141ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.04704955
142CMYC_18555785_Chip-Seq_ESCs_Mouse1.04363832
143SPI1_23127762_ChIP-Seq_K562_Human1.04222225
144RBPJ_21746931_ChIP-Seq_IB4_Human1.03915134
145OCT4_20526341_ChIP-Seq_ESCs_Human1.03857252
146VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.03831287
147ESRRB_18555785_Chip-Seq_ESCs_Mouse1.03734414
148P300_18555785_Chip-Seq_ESCs_Mouse1.03478406
149SPI1_26923725_Chip-Seq_HPCs_Mouse1.03352254
150CEBPB_22108803_ChIP-Seq_LS180_Human1.03210327
151GATA6_21074721_ChIP-Seq_CACO-2_Human1.02893084
152RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human1.02603951
153KLF4_18555785_Chip-Seq_ESCs_Mouse1.02275241
154SOX2_21211035_ChIP-Seq_LN229_Human1.02263684
155RUNX1_26923725_Chip-Seq_HPCs_Mouse1.01929903
156OCT4_21477851_ChIP-Seq_ESCs_Mouse1.01339893
157EZH2_27294783_Chip-Seq_NPCs_Mouse1.01005918
158MYC_27129775_Chip-Seq_CORNEA_Mouse1.00901807
159RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.00298696
160TAF15_26573619_Chip-Seq_HEK293_Human1.00072427
161EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.99306694
162SA1_27219007_Chip-Seq_Bcells_Human0.99218000
163SUZ12_18555785_Chip-Seq_ESCs_Mouse0.98888335
164* PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.98021844
165CTNNB1_20460455_ChIP-Seq_HCT116_Human0.97679765
166SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.96938477
167ELF1_17652178_ChIP-ChIP_JURKAT_Human0.96546808
168P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.96084465
169EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.95886674
170STAT3_18555785_Chip-Seq_ESCs_Mouse0.95870875
171CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.95817146
172ESET_19884257_ChIP-Seq_ESCs_Mouse0.95541350
173FOXA2_19822575_ChIP-Seq_HepG2_Human0.95220337
174GF1B_26923725_Chip-Seq_HPCs_Mouse0.94868761
175SOX2_18555785_Chip-Seq_ESCs_Mouse0.94394654
176GATA1_19941827_ChIP-Seq_MEL86_Mouse0.93928370
177E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.93539823
178CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.93366578
179NCOR1_26117541_ChIP-Seq_K562_Human0.93337101
180PPAR_26484153_Chip-Seq_NCI-H1993_Human0.93228865
181NFYB_21822215_ChIP-Seq_K562_Human0.92839551
182PU1_27457419_Chip-Seq_LIVER_Mouse0.92373922
183FLI1_21867929_ChIP-Seq_CD8_Mouse0.91617568
184SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.91106344
185PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.90999937
186LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.90633361
187RARA_24833708_ChIP-Seq_LIVER_Mouse0.90072128
188SOX9_26525672_Chip-Seq_HEART_Mouse0.89952356
189* PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.89897509
190E2F1_18555785_Chip-Seq_ESCs_Mouse0.89580249

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1* MP0003698_abnormal_male_reproductive5.93212037
2* MP0001929_abnormal_gametogenesis5.36937881
3MP0008877_abnormal_DNA_methylation4.01217218
4MP0009780_abnormal_chondrocyte_physiolo3.83301418
5MP0002277_abnormal_respiratory_mucosa3.39491149
6MP0002210_abnormal_sex_determination3.38479241
7MP0002653_abnormal_ependyma_morphology3.30859112
8* MP0002161_abnormal_fertility/fecundity3.18126907
9MP0001145_abnormal_male_reproductive2.84759576
10MP0008789_abnormal_olfactory_epithelium2.66503036
11MP0000653_abnormal_sex_gland2.47904024
12MP0003806_abnormal_nucleotide_metabolis2.32250244
13MP0005670_abnormal_white_adipose2.30803638
14MP0002168_other_aberrant_phenotype2.21330005
15MP0003656_abnormal_erythrocyte_physiolo2.18268452
16MP0005623_abnormal_meninges_morphology2.13849446
17MP0000678_abnormal_parathyroid_gland2.10301628
18MP0005083_abnormal_biliary_tract2.06058359
19MP0000465_gastrointestinal_hemorrhage2.00520344
20MP0005410_abnormal_fertilization16.0248839
21MP0002139_abnormal_hepatobiliary_system1.88609613
22MP0005499_abnormal_olfactory_system1.78200233
23MP0005394_taste/olfaction_phenotype1.78200233
24MP0003646_muscle_fatigue1.76265791
25MP0000566_synostosis1.69215259
26MP0009046_muscle_twitch1.57927031
27MP0000383_abnormal_hair_follicle1.57424762
28MP0005395_other_phenotype1.54114810
29MP0002282_abnormal_trachea_morphology1.50917886
30MP0002160_abnormal_reproductive_system1.48015795
31MP0010678_abnormal_skin_adnexa1.46976531
32MP0010155_abnormal_intestine_physiology1.45691099
33MP0004233_abnormal_muscle_weight1.42224244
34MP0003303_peritoneal_inflammation1.39787015
35MP0010234_abnormal_vibrissa_follicle1.39380354
36MP0001984_abnormal_olfaction1.39301208
37MP0005165_increased_susceptibility_to1.38644233
38MP0002249_abnormal_larynx_morphology1.33967211
39MP0008004_abnormal_stomach_pH1.33209907
40MP0005365_abnormal_bile_salt1.32899753
41MP0000681_abnormal_thyroid_gland1.25910861
42MP0001849_ear_inflammation1.23517001
43MP0009643_abnormal_urine_homeostasis1.17587344
44MP0002909_abnormal_adrenal_gland1.16623699
45MP0002876_abnormal_thyroid_physiology1.16178441
46MP0005377_hearing/vestibular/ear_phenot1.14183874
47MP0003878_abnormal_ear_physiology1.14183874
48MP0001765_abnormal_ion_homeostasis1.11803810
49MP0003195_calcinosis1.11453295
50MP0005085_abnormal_gallbladder_physiolo1.05997212
51MP0005164_abnormal_response_to1.01181210
52MP0005058_abnormal_lysosome_morphology0.98283573
53MP0002136_abnormal_kidney_physiology0.96162809
54MP0004264_abnormal_extraembryonic_tissu0.95704202
55MP0005647_abnormal_sex_gland0.95437080
56MP0004883_abnormal_blood_vessel0.94855344
57MP0001790_abnormal_immune_system0.93929071
58MP0005387_immune_system_phenotype0.93929071
59MP0001346_abnormal_lacrimal_gland0.93189539
60MP0002234_abnormal_pharynx_morphology0.92510481
61MP0003075_altered_response_to0.89002154
62MP0001666_abnormal_nutrient_absorption0.88656192
63MP0003453_abnormal_keratinocyte_physiol0.86201779
64MP0008995_early_reproductive_senescence0.83982383
65MP0003011_delayed_dark_adaptation0.83192995
66MP0009765_abnormal_xenobiotic_induced0.82022122
67MP0005389_reproductive_system_phenotype0.79851968
68MP0002736_abnormal_nociception_after0.78607458
69MP0005464_abnormal_platelet_physiology0.78260563
70MP0009763_increased_sensitivity_to0.75793062
71MP0005220_abnormal_exocrine_pancreas0.74716691
72MP0005423_abnormal_somatic_nervous0.73924662
73MP0001664_abnormal_digestion0.73913730
74MP0008058_abnormal_DNA_repair0.72571664
75MP0003172_abnormal_lysosome_physiology0.70070045
76MP0003866_abnormal_defecation0.68163630
77MP0005248_abnormal_Harderian_gland0.66977826
78MP0000858_altered_metastatic_potential0.66483212
79MP0003115_abnormal_respiratory_system0.64376804
80MP0005023_abnormal_wound_healing0.63460500
81MP0005166_decreased_susceptibility_to0.63438652
82MP0003045_fibrosis0.63432058
83MP0000467_abnormal_esophagus_morphology0.63078933
84MP0003950_abnormal_plasma_membrane0.62517429
85MP0005408_hypopigmentation0.61810841
86MP0009379_abnormal_foot_pigmentation0.60022273
87MP0010030_abnormal_orbit_morphology0.59666897
88MP0001270_distended_abdomen0.59015227
89MP0005636_abnormal_mineral_homeostasis0.57551785
90MP0003633_abnormal_nervous_system0.57286298
91MP0005310_abnormal_salivary_gland0.56923846
92MP0003329_amyloid_beta_deposits0.56918739
93MP0001968_abnormal_touch/_nociception0.55241115
94MP0005551_abnormal_eye_electrophysiolog0.55216308
95MP0003191_abnormal_cellular_cholesterol0.54405633
96MP0005253_abnormal_eye_physiology0.54304630
97MP0009115_abnormal_fat_cell0.53886336
98MP0002233_abnormal_nose_morphology0.53517225
99MP0005646_abnormal_pituitary_gland0.52829071
100MP0001440_abnormal_grooming_behavior0.52816160
101MP0002102_abnormal_ear_morphology0.52114891
102MP0005025_abnormal_response_to0.51344881
103MP0005319_abnormal_enzyme/_coenzyme0.50518684
104MP0001944_abnormal_pancreas_morphology0.50517456
105MP0001293_anophthalmia0.49979239
106MP0005376_homeostasis/metabolism_phenot0.48481189
107MP0000249_abnormal_blood_vessel0.47285929
108MP0004133_heterotaxia0.47089634
109MP0004036_abnormal_muscle_relaxation0.47042881
110MP0006082_CNS_inflammation0.46684886
111MP0003699_abnormal_female_reproductive0.45960945
112MP0005409_darkened_coat_color0.45504500
113MP0003718_maternal_effect0.44848239
114MP0002135_abnormal_kidney_morphology0.44490381
115MP0001663_abnormal_digestive_system0.44470782
116MP0002735_abnormal_chemical_nociception0.44086017
117MP0003136_yellow_coat_color0.43252679
118MP0001324_abnormal_eye_pigmentation0.42769214
119MP0004270_analgesia0.42366431
120MP0003186_abnormal_redox_activity0.42116101
121MP0002098_abnormal_vibrissa_morphology0.41292646
122MP0001835_abnormal_antigen_presentation0.40378754
123MP0004782_abnormal_surfactant_physiolog0.40241240
124MP0004885_abnormal_endolymph0.39990234
125MP0001764_abnormal_homeostasis0.38456231
126MP0002928_abnormal_bile_duct0.38432061
127MP0002971_abnormal_brown_adipose0.38041758
128MP0000534_abnormal_ureter_morphology0.37348206
129MP0005391_vision/eye_phenotype0.36223785
130MP0003631_nervous_system_phenotype0.35300457
131MP0004134_abnormal_chest_morphology0.33341713
132MP0003879_abnormal_hair_cell0.33305879
133MP0002152_abnormal_brain_morphology0.33261737
134MP0002132_abnormal_respiratory_system0.32628894
135MP0002572_abnormal_emotion/affect_behav0.31699052
136MP0005666_abnormal_adipose_tissue0.31319230
137MP0003942_abnormal_urinary_system0.31299512
138MP0003861_abnormal_nervous_system0.31032101
139MP0004043_abnormal_pH_regulation0.29492815
140MP0003634_abnormal_glial_cell0.29451151
141MP0002269_muscular_atrophy0.29428150
142MP0009250_abnormal_appendicular_skeleto0.29333756
143MP0000358_abnormal_cell_content/0.28967556
144MP0002133_abnormal_respiratory_system0.28663244
145MP0005388_respiratory_system_phenotype0.28663244
146MP0004019_abnormal_vitamin_homeostasis0.28041237
147MP0001545_abnormal_hematopoietic_system0.27319121
148MP0005397_hematopoietic_system_phenotyp0.27319121
149MP0001119_abnormal_female_reproductive0.26512957
150MP0002295_abnormal_pulmonary_circulatio0.25618000
151MP0004145_abnormal_muscle_electrophysio0.25471931
152MP0006036_abnormal_mitochondrial_physio0.25424546
153MP0001963_abnormal_hearing_physiology0.24763943
154MP0002229_neurodegeneration0.23379027
155MP0003948_abnormal_gas_homeostasis0.23308448
156MP0005195_abnormal_posterior_eye0.23254988
157MP0008057_abnormal_DNA_replication0.23068450
158MP0009278_abnormal_bone_marrow0.22397880
159MP0000026_abnormal_inner_ear0.21419116
160MP0008875_abnormal_xenobiotic_pharmacok0.21190915
161MP0004742_abnormal_vestibular_system0.21132020
162MP0000604_amyloidosis0.20619266
163MP0001485_abnormal_pinna_reflex0.20528442
164MP0002405_respiratory_system_inflammati0.20486218
165MP0004811_abnormal_neuron_physiology0.20353204
166MP0003786_premature_aging0.19833230
167MP0003690_abnormal_glial_cell0.19776265
168MP0002557_abnormal_social/conspecific_i0.19508769
169MP0000432_abnormal_head_morphology0.19170097
170MP0002752_abnormal_somatic_nervous0.18223321
171MP0002272_abnormal_nervous_system0.18208201
172MP0010094_abnormal_chromosome_stability0.17856947
173MP0009697_abnormal_copulation0.17739361
174MP0000462_abnormal_digestive_system0.17732800
175MP0002734_abnormal_mechanical_nocicepti0.17448916
176MP0002169_no_abnormal_phenotype0.17242878

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium morphology (HP:0005938)9.31128389
2Abnormal respiratory epithelium morphology (HP:0012253)9.31128389
3Abnormal ciliary motility (HP:0012262)8.53705632
4Rhinitis (HP:0012384)8.51170024
5Chronic bronchitis (HP:0004469)7.71506085
6Nasal polyposis (HP:0100582)6.27699753
7Infertility (HP:0000789)6.14249846
8Abnormality of the nasal mucosa (HP:0000433)5.19101015
9Bronchiectasis (HP:0002110)4.92557971
10Bronchitis (HP:0012387)4.65359669
11Nephronophthisis (HP:0000090)4.22138273
12Male infertility (HP:0003251)3.79708872
13Recurrent sinusitis (HP:0011108)3.60516771
14Atelectasis (HP:0100750)3.41456757
15Recurrent otitis media (HP:0000403)3.39875468
16Abnormality of the renal medulla (HP:0100957)3.23442951
17Chronic otitis media (HP:0000389)3.16482188
18Abnormal spermatogenesis (HP:0008669)3.05287509
19Hyperactive renin-angiotensin system (HP:0000841)2.89801461
20Tubulointerstitial nephritis (HP:0001970)2.88147841
21Molar tooth sign on MRI (HP:0002419)2.80880888
22Abnormality of midbrain morphology (HP:0002418)2.80880888
23Tubular atrophy (HP:0000092)2.79293155
24Medial flaring of the eyebrow (HP:0010747)2.78946001
25Recurrent bronchitis (HP:0002837)2.61262058
26Tubulointerstitial abnormality (HP:0001969)2.50198698
27Tubulointerstitial fibrosis (HP:0005576)2.14594688
28Postaxial foot polydactyly (HP:0001830)2.11907787
29Azoospermia (HP:0000027)2.11075966
30Impulsivity (HP:0100710)2.09665487
31Pancreatic fibrosis (HP:0100732)2.07198576
32Congenital hepatic fibrosis (HP:0002612)2.01181469
33Abnormal drinking behavior (HP:0030082)2.00408262
34Polydipsia (HP:0001959)2.00408262
35Respiratory insufficiency due to defective ciliary clearance (HP:0200073)14.0193015
36Dynein arm defect of respiratory motile cilia (HP:0012255)12.4460429
37Absent/shortened dynein arms (HP:0200106)12.4460429
38Abnormal respiratory motile cilium physiology (HP:0012261)10.2881304
39Gonadotropin excess (HP:0000837)1.98479992
40Male pseudohermaphroditism (HP:0000037)1.94469260
41Stage 5 chronic kidney disease (HP:0003774)1.91856461
42Chronic sinusitis (HP:0011109)1.90359601
43Fibular hypoplasia (HP:0003038)1.86430685
44Renal salt wasting (HP:0000127)1.84827030
45Abnormality of renal excretion (HP:0011036)1.82569909
46Bile duct proliferation (HP:0001408)1.82479740
47Abnormal biliary tract physiology (HP:0012439)1.82479740
48True hermaphroditism (HP:0010459)1.81251347
49Congenital primary aphakia (HP:0007707)1.77441926
50Gait imbalance (HP:0002141)1.76661246
51Abnormality of the renal cortex (HP:0011035)1.76532968
52Anencephaly (HP:0002323)1.76063503
53Cholecystitis (HP:0001082)1.74226638
54Abnormal gallbladder physiology (HP:0012438)1.74226638
55Renal dysplasia (HP:0000110)1.74198762
56Asplenia (HP:0001746)1.73832725
57Taurodontia (HP:0000679)1.73824444
58Abnormality of permanent molar morphology (HP:0011071)1.73824444
59Abnormality of the dental root (HP:0006486)1.73824444
60Cystic liver disease (HP:0006706)1.72630491
61Microglossia (HP:0000171)1.72258827
62Aplasia/Hypoplasia of the spleen (HP:0010451)1.71265882
63Median cleft lip (HP:0000161)1.70424722
64Aplasia/Hypoplasia of the tongue (HP:0010295)1.69505163
65Abnormality of the dental pulp (HP:0006479)1.69314903
66Postaxial hand polydactyly (HP:0001162)1.66136891
67Aplasia/Hypoplasia of the lens (HP:0008063)1.65442008
68Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.65258204
69Decreased circulating renin level (HP:0003351)1.63737490
70Abnormality of dentin (HP:0010299)1.63046333
71Abnormality of molar (HP:0011077)1.61490027
72Abnormality of molar morphology (HP:0011070)1.61490027
73Decreased central vision (HP:0007663)1.60067920
74Abnormal urine output (HP:0012590)1.58667207
75Facial cleft (HP:0002006)1.56463759
76Short ribs (HP:0000773)1.55913299
77Oculomotor apraxia (HP:0000657)1.55025284
78Furrowed tongue (HP:0000221)1.52913155
79Dyschromatopsia (HP:0007641)1.49740128
80Nephrogenic diabetes insipidus (HP:0009806)1.49410044
81Bell-shaped thorax (HP:0001591)1.48502508
82Hemiparesis (HP:0001269)1.48459610
83Hyperkalemia (HP:0002153)1.47500360
84Genital tract atresia (HP:0001827)1.43399991
85Abnormality of monocarboxylic acid metabolism (HP:0010996)1.43259635
86Pancreatic cysts (HP:0001737)1.42129885
87Neurofibrillary tangles (HP:0002185)1.41032257
88Hypoplasia of the capital femoral epiphysis (HP:0003090)1.39791222
89Hyperaldosteronism (HP:0000859)1.38854888
90Abnormality of renin-angiotensin system (HP:0000847)1.37153779
91Vaginal atresia (HP:0000148)1.35047708
92Choroideremia (HP:0001139)1.34731015
93Nephropathy (HP:0000112)1.34590461
94J-shaped sella turcica (HP:0002680)1.34376429
95Congenital malformation of the right heart (HP:0011723)1.34192282
96Double outlet right ventricle (HP:0001719)1.34192282
97Polyuria (HP:0000103)1.33579452
98Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.33402555
99Absent rod-and cone-mediated responses on ERG (HP:0007688)1.33138477
100Spastic tetraparesis (HP:0001285)1.32034428
101Abnormality of the frontal sinuses (HP:0002687)1.29597998
102Occipital encephalocele (HP:0002085)1.29391114
103Poor coordination (HP:0002370)1.29049122
104Abnormality of the lower motor neuron (HP:0002366)1.28899191
105Retinal dysplasia (HP:0007973)1.28748041
106Absent frontal sinuses (HP:0002688)1.28071089
107Deformed sella turcica (HP:0002681)1.27913405
108Chronic hepatic failure (HP:0100626)1.24941891
109Heterotopia (HP:0002282)1.24786488
110Hypokalemic alkalosis (HP:0001949)1.24526447
111Supernumerary spleens (HP:0009799)1.23927991
112Abnormality of saccadic eye movements (HP:0000570)1.22679524
113Abnormality of chloride homeostasis (HP:0011422)1.21412799
114Aplasia/Hypoplasia of the fibula (HP:0006492)1.20567650
115Hand muscle atrophy (HP:0009130)1.19270929
116Bifid scrotum (HP:0000048)1.18665986
117Short thorax (HP:0010306)1.18480123
118Short nail (HP:0001799)1.17610707
119Stridor (HP:0010307)1.17580971
120Abnormality of the distal phalanges of the toes (HP:0010182)1.16949560
121Sclerocornea (HP:0000647)1.15415270
122Hyponatremia (HP:0002902)1.14593834
123Glucose intolerance (HP:0000833)1.14376591
124Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.12625706
125Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.12111390
126Recurrent pneumonia (HP:0006532)1.11357790
127Obstructive sleep apnea (HP:0002870)1.10595537
128Impaired proprioception (HP:0010831)1.10522450
129Amyotrophic lateral sclerosis (HP:0007354)1.10468042
130Preaxial hand polydactyly (HP:0001177)1.08692046
131Aplasia of the musculature (HP:0100854)1.08197135
132Self-mutilation (HP:0000742)1.04227428
133Fetal akinesia sequence (HP:0001989)1.03223846
134Diaphragmatic weakness (HP:0009113)1.01673483
135Short femoral neck (HP:0100864)1.01591484
136Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)1.01034499
137Muscle fiber splitting (HP:0003555)0.99002318
138Flat acetabular roof (HP:0003180)0.97931597
139Popliteal pterygium (HP:0009756)0.97639942
140Lip pit (HP:0100267)0.96397758
141Spinal muscular atrophy (HP:0007269)0.94885411
142Ventricular fibrillation (HP:0001663)0.94589378
143Carpal bone hypoplasia (HP:0001498)0.93489398

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK38.40240111
2PDK48.40240111
3TESK15.81677355
4MST45.77065141
5PDK25.40703541
6PRKD34.85479219
7EPHA24.42427633
8ICK3.83950338
9SMG12.54472441
10MAPKAPK32.46337810
11PTK2B2.42518560
12WNK42.20288002
13PNCK2.18913892
14NME12.18245311
15STK392.15608191
16MAP3K21.90316741
17STK381.75938508
18MAPK151.69271597
19MAP3K31.64421752
20TLK11.55941094
21TBK11.52516983
22NEK21.46323446
23CSK1.45121892
24EPHB11.39266375
25DYRK1B1.31072571
26STK241.28060405
27PDK11.15848909
28TAOK31.11005564
29EPHA31.10854606
30LRRK21.08199828
31MST1R1.01598458
32TRPM70.93662203
33LMTK20.92032500
34TYRO30.91020864
35GRK60.85695402
36MYLK0.84463538
37DYRK30.80041920
38MAP3K70.78902575
39WNK10.77339202
40IRAK10.76522795
41CCNB10.74197603
42PDPK10.73683494
43CAMK2G0.70206528
44PRKCI0.68676196
45STK38L0.66663002
46STK30.61250630
47BCR0.60004228
48NTRK20.59884234
49WEE10.58881414
50CHEK20.57840010
51MUSK0.57192164
52TTK0.56906100
53PINK10.56842747
54PASK0.55765363
55HIPK20.54908089
56RIPK40.53728268
57RPS6KB20.49364887
58MAP3K120.48206815
59CDC42BPA0.47579172
60ARAF0.46236031
61BMPR20.46204357
62ILK0.44228608
63PBK0.43788372
64LATS10.43125410
65CAMK1G0.43123335
66ERBB20.42859898
67PIM20.42818098
68TAOK10.42458921
69MAP2K60.42266664
70PRKCG0.41241995
71IKBKE0.39317904
72EEF2K0.37006591
73TESK20.36276058
74TYK20.36191012
75MAPK110.36130925
76AKT20.35343640
77ROCK20.34515630
78IRAK20.33471392
79CHEK10.33164778
80PLK40.31974717
81PRKAA20.31647667
82PAK10.30729642
83INSRR0.30336130
84BRSK20.29302250
85MATK0.29280644
86FER0.29203968
87FGFR30.29017594
88RIPK10.28502564
89MAPK120.28070352
90NEK60.28050758
91PAK20.26667952
92ATM0.25511247
93ABL10.25234996
94RET0.25006221
95MAP2K20.24633475
96PRKD20.24171481
97NLK0.23627781
98STK100.23147757
99IRAK40.22453170
100PRKCQ0.22328036
101MARK20.21555814
102BTK0.21258689
103MAP3K10.21037412
104RPS6KA50.20936505
105ATR0.20034476
106MAP3K80.19311648
107MAPKAPK50.18643129
108BRAF0.18563147
109FGFR40.18077417
110DAPK10.17889387
111PRKAA10.17888468
112MAP2K70.17769664
113SGK10.17532534
114MARK30.17330489
115MAP3K110.17042632
116ERBB30.16370600
117STK160.15465998
118ROCK10.15323416
119CAMKK10.14808622
120CAMK2A0.14789627
121PRKCZ0.14723170
122BRSK10.14265043
123TEC0.13851920
124RPS6KA20.13726327
125MAP3K40.13581545
126MAP3K100.13305109
127PTK60.13045331
128MTOR0.12550439
129RPS6KB10.12398155
130IKBKB0.12206485
131FYN0.12067089
132PKN10.11889573
133PRKG10.11372656
134CDK30.10906711
135PRKG20.10748286
136PLK10.10196715
137CDK150.09307757
138PRKACG0.08764992
139YES10.07999692
140RPS6KA10.07737946
141CDK180.06459144
142CSNK2A10.06298472
143PRKCA0.05870234
144GSK3B0.05260927
145ZAP700.05190742
146CDK11A0.05131505
147PRKACA0.03912309
148PRKCD0.03627866
149PHKG10.03282756
150PHKG20.03282756
151STK110.03200792
152CDC70.03096383
153TRIB30.02386353
154GRK10.02336396
155CDK140.02238268
156BMPR1B0.02000552
157MAPK80.01724178
158PRKDC0.01279592
159AURKA0.01278726
160EGFR0.01132523
161MARK10.00679284
162CDK10.00349791
163CSNK2A20.00034777
164SRC-0.0116462
165PDGFRB-0.0111605
166PAK4-0.0082222
167CSNK1D-0.0070813
168PRKCB-0.0014426

Predicted pathways (KEGG)

RankGene SetZ-score
1Phenylalanine metabolism_Homo sapiens_hsa003605.33378994
2Fatty acid biosynthesis_Homo sapiens_hsa000614.91452651
3Histidine metabolism_Homo sapiens_hsa003404.44516564
4Tyrosine metabolism_Homo sapiens_hsa003504.17780885
5Vitamin B6 metabolism_Homo sapiens_hsa007504.06598034
6Glycolysis / Gluconeogenesis_Homo sapiens_hsa000103.97223010
7Pyruvate metabolism_Homo sapiens_hsa006203.41345539
8Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.93682707
9alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.88508540
10beta-Alanine metabolism_Homo sapiens_hsa004102.84835643
11Linoleic acid metabolism_Homo sapiens_hsa005912.79305130
12Propanoate metabolism_Homo sapiens_hsa006402.76134464
13Glucagon signaling pathway_Homo sapiens_hsa049222.44930516
14Basal transcription factors_Homo sapiens_hsa030222.24839263
15Carbohydrate digestion and absorption_Homo sapiens_hsa049732.12868780
16Pentose phosphate pathway_Homo sapiens_hsa000302.10406154
17PPAR signaling pathway_Homo sapiens_hsa033201.96628797
18Caffeine metabolism_Homo sapiens_hsa002321.96025596
19Dorso-ventral axis formation_Homo sapiens_hsa043201.86430874
20Selenocompound metabolism_Homo sapiens_hsa004501.84839015
21Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.84171816
22Glycerolipid metabolism_Homo sapiens_hsa005611.80311855
23Sphingolipid metabolism_Homo sapiens_hsa006001.78501876
24Steroid hormone biosynthesis_Homo sapiens_hsa001401.68779636
25Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.66808034
26Glycerophospholipid metabolism_Homo sapiens_hsa005641.64099529
27Ether lipid metabolism_Homo sapiens_hsa005651.62383995
28Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.55791417
29Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.55385226
30Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.55178454
31Mineral absorption_Homo sapiens_hsa049781.54958071
32Amphetamine addiction_Homo sapiens_hsa050311.54176635
33Huntingtons disease_Homo sapiens_hsa050161.52370103
34Glycosaminoglycan degradation_Homo sapiens_hsa005311.49572978
35Cardiac muscle contraction_Homo sapiens_hsa042601.47969956
36Oocyte meiosis_Homo sapiens_hsa041141.46021519
37Fatty acid degradation_Homo sapiens_hsa000711.45446711
38Fatty acid metabolism_Homo sapiens_hsa012121.45161908
39Fructose and mannose metabolism_Homo sapiens_hsa000511.45077129
40Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.44642475
41Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.26087487
42Fanconi anemia pathway_Homo sapiens_hsa034601.24912627
43Carbon metabolism_Homo sapiens_hsa012001.23708139
44Drug metabolism - other enzymes_Homo sapiens_hsa009831.23447401
45Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.22466328
46Fat digestion and absorption_Homo sapiens_hsa049751.22358888
47Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.21796107
48Renin secretion_Homo sapiens_hsa049241.18895859
49Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.11848856
50Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.10678447
51Cysteine and methionine metabolism_Homo sapiens_hsa002701.03870336
52Glutathione metabolism_Homo sapiens_hsa004801.02808303
53Renin-angiotensin system_Homo sapiens_hsa046141.00044287
54Purine metabolism_Homo sapiens_hsa002300.97596447
55Primary bile acid biosynthesis_Homo sapiens_hsa001200.96047292
56Complement and coagulation cascades_Homo sapiens_hsa046100.94073614
57Chemical carcinogenesis_Homo sapiens_hsa052040.91988321
58Starch and sucrose metabolism_Homo sapiens_hsa005000.91593936
59Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.91549765
60Hedgehog signaling pathway_Homo sapiens_hsa043400.90591324
61Insulin secretion_Homo sapiens_hsa049110.89992147
62Tight junction_Homo sapiens_hsa045300.88095614
63Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.85249575
64Arachidonic acid metabolism_Homo sapiens_hsa005900.82031107
65Thyroid hormone synthesis_Homo sapiens_hsa049180.81784452
66Bile secretion_Homo sapiens_hsa049760.80882591
67Biosynthesis of amino acids_Homo sapiens_hsa012300.80505061
68Adipocytokine signaling pathway_Homo sapiens_hsa049200.78586274
69Antigen processing and presentation_Homo sapiens_hsa046120.77813183
70Collecting duct acid secretion_Homo sapiens_hsa049660.75896495
71Calcium signaling pathway_Homo sapiens_hsa040200.74492197
72Hepatitis C_Homo sapiens_hsa051600.73204285
73Long-term potentiation_Homo sapiens_hsa047200.72501348
74Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.72469607
75Salivary secretion_Homo sapiens_hsa049700.71675354
76cGMP-PKG signaling pathway_Homo sapiens_hsa040220.71021244
77Intestinal immune network for IgA production_Homo sapiens_hsa046720.70131590
78Estrogen signaling pathway_Homo sapiens_hsa049150.69241931
79Gastric acid secretion_Homo sapiens_hsa049710.68833714
80Pancreatic secretion_Homo sapiens_hsa049720.68197126
81Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.67310760
82Hematopoietic cell lineage_Homo sapiens_hsa046400.65997670
83mRNA surveillance pathway_Homo sapiens_hsa030150.63755377
84Choline metabolism in cancer_Homo sapiens_hsa052310.62168634
85Taste transduction_Homo sapiens_hsa047420.61184098
86Type I diabetes mellitus_Homo sapiens_hsa049400.56865045
87Leukocyte transendothelial migration_Homo sapiens_hsa046700.55872972
88Lysosome_Homo sapiens_hsa041420.54766914
89Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.52859702
90Nitrogen metabolism_Homo sapiens_hsa009100.51592952
91Allograft rejection_Homo sapiens_hsa053300.50558711
92Asthma_Homo sapiens_hsa053100.48688928
93ABC transporters_Homo sapiens_hsa020100.47534339
94Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.46968333
95Other glycan degradation_Homo sapiens_hsa005110.46792625
96Systemic lupus erythematosus_Homo sapiens_hsa053220.46718744
97Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.46375350
98Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.46068302
99cAMP signaling pathway_Homo sapiens_hsa040240.44693681
100Vascular smooth muscle contraction_Homo sapiens_hsa042700.44662815
101Autoimmune thyroid disease_Homo sapiens_hsa053200.42103798
102Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.42022138
103Circadian rhythm_Homo sapiens_hsa047100.42008894
104Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.41074149
105Protein digestion and absorption_Homo sapiens_hsa049740.40433322
106Metabolic pathways_Homo sapiens_hsa011000.40076222
107Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.39199190
108Central carbon metabolism in cancer_Homo sapiens_hsa052300.38798084
109RNA transport_Homo sapiens_hsa030130.38749859
110Arginine biosynthesis_Homo sapiens_hsa002200.38357957
111Graft-versus-host disease_Homo sapiens_hsa053320.37101380
112Thyroid hormone signaling pathway_Homo sapiens_hsa049190.36057029
113RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.36040370
114Sphingolipid signaling pathway_Homo sapiens_hsa040710.35636508
115Cocaine addiction_Homo sapiens_hsa050300.34654091
116AMPK signaling pathway_Homo sapiens_hsa041520.33422623
117Phagosome_Homo sapiens_hsa041450.33194590
118Notch signaling pathway_Homo sapiens_hsa043300.32953669
119Circadian entrainment_Homo sapiens_hsa047130.32642288
120N-Glycan biosynthesis_Homo sapiens_hsa005100.32353947
121Transcriptional misregulation in cancer_Homo sapiens_hsa052020.32265569
122Phosphatidylinositol signaling system_Homo sapiens_hsa040700.31683956
123Inositol phosphate metabolism_Homo sapiens_hsa005620.31377805
124Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.31114564
125Synaptic vesicle cycle_Homo sapiens_hsa047210.31046227
126Apoptosis_Homo sapiens_hsa042100.30536945
127Olfactory transduction_Homo sapiens_hsa047400.29311127
128Nicotine addiction_Homo sapiens_hsa050330.28616077
129Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.28330560
130Staphylococcus aureus infection_Homo sapiens_hsa051500.27936946
131Glutamatergic synapse_Homo sapiens_hsa047240.27226901
132Rheumatoid arthritis_Homo sapiens_hsa053230.27077090
133Basal cell carcinoma_Homo sapiens_hsa052170.26755657
134Endocytosis_Homo sapiens_hsa041440.26682175
135Arginine and proline metabolism_Homo sapiens_hsa003300.26513211
136Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.24805155
137Sulfur metabolism_Homo sapiens_hsa009200.24779264
138VEGF signaling pathway_Homo sapiens_hsa043700.24012360
139Alcoholism_Homo sapiens_hsa050340.22664458
140Jak-STAT signaling pathway_Homo sapiens_hsa046300.21989873
141Pentose and glucuronate interconversions_Homo sapiens_hsa000400.21737149
142Amoebiasis_Homo sapiens_hsa051460.18690083
143Wnt signaling pathway_Homo sapiens_hsa043100.16944353
144Butanoate metabolism_Homo sapiens_hsa006500.16184753
145Retinol metabolism_Homo sapiens_hsa008300.15690037
146Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.15134830
147B cell receptor signaling pathway_Homo sapiens_hsa046620.14982314
148Peroxisome_Homo sapiens_hsa041460.12904418
149Insulin resistance_Homo sapiens_hsa049310.12864382
150Adherens junction_Homo sapiens_hsa045200.12663366
151Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.12176031
152Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.11541265
153Regulation of autophagy_Homo sapiens_hsa041400.11051741
154Vitamin digestion and absorption_Homo sapiens_hsa049770.11031770
155Cyanoamino acid metabolism_Homo sapiens_hsa004600.09822473
156SNARE interactions in vesicular transport_Homo sapiens_hsa041300.08765375
157Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.07579638
158Pyrimidine metabolism_Homo sapiens_hsa002400.07114107
159Legionellosis_Homo sapiens_hsa051340.06842806
160Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.05673843
161Prostate cancer_Homo sapiens_hsa052150.04183679
162Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.03343799

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