TEFM

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1proline biosynthetic process (GO:0006561)8.32790507
2DNA deamination (GO:0045006)7.06325196
3replication fork processing (GO:0031297)6.37910585
4proline metabolic process (GO:0006560)6.33729954
5embryonic process involved in female pregnancy (GO:0060136)6.01700135
6maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)5.44244558
7viral mRNA export from host cell nucleus (GO:0046784)5.13184831
8maturation of 5.8S rRNA (GO:0000460)5.12901887
9telomere maintenance via semi-conservative replication (GO:0032201)5.11403087
10formation of translation preinitiation complex (GO:0001731)5.06877378
11positive regulation of protein homooligomerization (GO:0032464)5.05963777
12somatic hypermutation of immunoglobulin genes (GO:0016446)4.93033755
13somatic diversification of immune receptors via somatic mutation (GO:0002566)4.93033755
14* transcription from mitochondrial promoter (GO:0006390)4.88141171
15establishment of protein localization to mitochondrial membrane (GO:0090151)4.69936767
16oxidative demethylation (GO:0070989)4.69089519
17mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.50083928
18DNA strand renaturation (GO:0000733)4.47106009
19nucleotide-excision repair, DNA gap filling (GO:0006297)4.35839751
20telomere maintenance via recombination (GO:0000722)4.34762462
21DNA strand elongation involved in DNA replication (GO:0006271)4.32622708
22kinetochore assembly (GO:0051382)4.32221014
23protein complex biogenesis (GO:0070271)4.24303591
24mitotic G1 DNA damage checkpoint (GO:0031571)4.22153089
25regulation of protein homooligomerization (GO:0032462)4.15943916
26DNA strand elongation (GO:0022616)4.13272849
27mitochondrial respiratory chain complex assembly (GO:0033108)4.12452543
28establishment of apical/basal cell polarity (GO:0035089)4.10925018
29chaperone-mediated protein transport (GO:0072321)4.09387341
30regulation of integrin activation (GO:0033623)4.04515366
31respiratory chain complex IV assembly (GO:0008535)4.04420974
32poly(A)+ mRNA export from nucleus (GO:0016973)4.03821813
33mRNA cleavage (GO:0006379)4.03760768
34base-excision repair (GO:0006284)4.00145309
35chromatin remodeling at centromere (GO:0031055)3.97657221
36ribosome biogenesis (GO:0042254)3.95785091
37DNA double-strand break processing (GO:0000729)3.95211409
38mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.93884828
39mitochondrial respiratory chain complex I assembly (GO:0032981)3.93884828
40NADH dehydrogenase complex assembly (GO:0010257)3.93884828
41exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.91042855
42CENP-A containing nucleosome assembly (GO:0034080)3.87802119
43cytochrome complex assembly (GO:0017004)3.86485417
44regulation of double-strand break repair via homologous recombination (GO:0010569)3.85256189
45non-recombinational repair (GO:0000726)3.81463062
46double-strand break repair via nonhomologous end joining (GO:0006303)3.81463062
47energy coupled proton transport, down electrochemical gradient (GO:0015985)3.80809111
48ATP synthesis coupled proton transport (GO:0015986)3.80809111
49meiotic chromosome segregation (GO:0045132)3.79667471
50DNA integration (GO:0015074)3.78875901
51kinetochore organization (GO:0051383)3.77762688
52mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.73439965
53GDP-mannose metabolic process (GO:0019673)3.72721114
54G1 DNA damage checkpoint (GO:0044783)3.71516816
55proteasome assembly (GO:0043248)3.70220312
56termination of RNA polymerase II transcription (GO:0006369)3.69172011
57mitotic G1/S transition checkpoint (GO:0044819)3.68517345
58telomere maintenance via telomere lengthening (GO:0010833)3.68298964
59mitotic recombination (GO:0006312)3.67567704
60cullin deneddylation (GO:0010388)3.65318529
61negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.64531941
62tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.63939731
63RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.63939731
64dosage compensation (GO:0007549)3.59952067
65base-excision repair, AP site formation (GO:0006285)3.57523584
66negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.56413285
67negative regulation of JAK-STAT cascade (GO:0046426)3.54754169
68DNA ligation (GO:0006266)3.54733287
69establishment or maintenance of monopolar cell polarity (GO:0061339)3.52774616
70establishment of monopolar cell polarity (GO:0061162)3.52774616
71rRNA modification (GO:0000154)3.52654249
72pseudouridine synthesis (GO:0001522)3.50291460
73histone exchange (GO:0043486)3.48949627
74regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.48396546
75regulation of mitotic spindle checkpoint (GO:1903504)3.48396546
76regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.48047663
77positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.47994765
78DNA catabolic process, exonucleolytic (GO:0000738)3.45780050
79termination of RNA polymerase III transcription (GO:0006386)3.44552693
80transcription elongation from RNA polymerase III promoter (GO:0006385)3.44552693
81negative regulation of fatty acid biosynthetic process (GO:0045717)3.42142655
82pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.41283215
83peptidyl-histidine modification (GO:0018202)3.35913459
84* mitochondrial DNA metabolic process (GO:0032042)3.35129237
85protein-cofactor linkage (GO:0018065)3.35040444
86protein deneddylation (GO:0000338)3.34274246
87regulation of translational fidelity (GO:0006450)3.32390733
88negative regulation of cell cycle arrest (GO:0071157)3.31503406
89inner mitochondrial membrane organization (GO:0007007)3.31425203
90glutamine family amino acid biosynthetic process (GO:0009084)3.29084039
91respiratory electron transport chain (GO:0022904)3.27032254
92positive regulation of DNA repair (GO:0045739)3.25974698
93anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.25678982
94electron transport chain (GO:0022900)3.22993085
95regulation of mitochondrial translation (GO:0070129)3.22743383
96negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.22518585
97negative regulation of ligase activity (GO:0051352)3.22518585
98DNA topological change (GO:0006265)3.19763616
99rRNA processing (GO:0006364)3.17023572
100protein neddylation (GO:0045116)3.16612777
101regulation of cellular amino acid metabolic process (GO:0006521)3.16501570
102transcription-coupled nucleotide-excision repair (GO:0006283)3.15549983
103ribonucleoprotein complex biogenesis (GO:0022613)3.15421269
104platelet dense granule organization (GO:0060155)3.15166844
105spliceosomal tri-snRNP complex assembly (GO:0000244)3.12962404
106DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.12300516
107embryonic placenta development (GO:0001892)3.11555527
108spliceosomal snRNP assembly (GO:0000387)3.11340487
109signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.11211482
110signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.11211482
111signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.11211482
112negative regulation of mRNA processing (GO:0050686)3.10919880
113negative regulation of DNA-dependent DNA replication (GO:2000104)3.07876653
114protein K6-linked ubiquitination (GO:0085020)3.06708178
115recombinational repair (GO:0000725)3.05495069
116nucleobase biosynthetic process (GO:0046112)3.04991481
117intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.04517513
118signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.04517513
119positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.04382108
120rRNA metabolic process (GO:0016072)3.04147227
121somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.03131316
122isotype switching (GO:0045190)3.03131316
123somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.03131316
124double-strand break repair via homologous recombination (GO:0000724)3.02809104
125regulation of double-strand break repair (GO:2000779)3.02216024
126kynurenine metabolic process (GO:0070189)3.01251797
127RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.00630517
128synapsis (GO:0007129)2.98678308
129DNA replication-dependent nucleosome organization (GO:0034723)2.96523573
130DNA replication-dependent nucleosome assembly (GO:0006335)2.96523573
131regulation of sister chromatid cohesion (GO:0007063)2.96279345
132negative regulation of RNA splicing (GO:0033119)2.96262920
133tRNA processing (GO:0008033)2.95135548
134purine nucleobase biosynthetic process (GO:0009113)2.94813458
135positive regulation of mitotic sister chromatid separation (GO:1901970)2.94460537
136positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.94460537
137positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.94460537
138signal transduction involved in DNA integrity checkpoint (GO:0072401)2.94148549
139signal transduction involved in DNA damage checkpoint (GO:0072422)2.94148549
140signal transduction involved in cell cycle checkpoint (GO:0072395)2.93902260
141cellular response to ATP (GO:0071318)2.93796926
142histone mRNA metabolic process (GO:0008334)2.93752883
143regulation of gene silencing by RNA (GO:0060966)2.93752381
144regulation of posttranscriptional gene silencing (GO:0060147)2.93752381
145regulation of gene silencing by miRNA (GO:0060964)2.93752381
146positive regulation of ligase activity (GO:0051351)2.93413035
147water-soluble vitamin biosynthetic process (GO:0042364)2.92878034
148mRNA export from nucleus (GO:0006406)2.92805832
149negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.92239031
150mannosylation (GO:0097502)2.91130887
151positive regulation of developmental pigmentation (GO:0048087)2.89826600
152rRNA methylation (GO:0031167)2.88233630
153* mitochondrial RNA metabolic process (GO:0000959)2.87291687
154resolution of meiotic recombination intermediates (GO:0000712)2.86579635
155positive regulation by host of viral transcription (GO:0043923)2.85756979
156histone H4-K12 acetylation (GO:0043983)2.85647232
157tryptophan catabolic process (GO:0006569)2.85144596
158indole-containing compound catabolic process (GO:0042436)2.85144596
159indolalkylamine catabolic process (GO:0046218)2.85144596
160DNA-templated transcription, termination (GO:0006353)2.85005809
161cellular response to zinc ion (GO:0071294)2.84387738
162DNA replication-independent nucleosome organization (GO:0034724)2.83276984
163DNA replication-independent nucleosome assembly (GO:0006336)2.83276984
164DNA demethylation (GO:0080111)2.82958382
165L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.82571297
166positive regulation of protein oligomerization (GO:0032461)2.81628660
167nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.81160694
168piRNA metabolic process (GO:0034587)2.80181719
169RNA export from nucleus (GO:0006405)2.79906028
170organelle disassembly (GO:1903008)2.79449318
171DNA replication initiation (GO:0006270)2.78407348
172single strand break repair (GO:0000012)2.78400753
173DNA replication checkpoint (GO:0000076)2.77637585
174nodal signaling pathway (GO:0038092)2.77489468
175mitotic sister chromatid segregation (GO:0000070)2.77474822
176postreplication repair (GO:0006301)2.77047041
177protein targeting to mitochondrion (GO:0006626)2.74880931
178tRNA metabolic process (GO:0006399)2.73140374

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYC_18555785_ChIP-Seq_MESCs_Mouse4.32186993
2E2F7_22180533_ChIP-Seq_HELA_Human4.20114154
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.35197415
4JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.09818779
5MYC_18358816_ChIP-ChIP_MESCs_Mouse3.02972751
6MYC_19079543_ChIP-ChIP_MESCs_Mouse2.99194673
7MYC_19030024_ChIP-ChIP_MESCs_Mouse2.80649206
8ZNF274_21170338_ChIP-Seq_K562_Hela2.77944370
9ETS1_20019798_ChIP-Seq_JURKAT_Human2.63066909
10SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.61271834
11EST1_17652178_ChIP-ChIP_JURKAT_Human2.51650762
12KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.48088885
13GABP_17652178_ChIP-ChIP_JURKAT_Human2.45846761
14CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.37040719
15KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.29771013
16KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.29771013
17KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.29771013
18E2F1_18555785_ChIP-Seq_MESCs_Mouse2.27485873
19HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.27172795
20E2F4_17652178_ChIP-ChIP_JURKAT_Human2.18375707
21ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.13630064
22* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.13227606
23VDR_22108803_ChIP-Seq_LS180_Human2.12541081
24THAP11_20581084_ChIP-Seq_MESCs_Mouse2.10801102
25NELFA_20434984_ChIP-Seq_ESCs_Mouse2.05885524
26DCP1A_22483619_ChIP-Seq_HELA_Human2.03345290
27YY1_21170310_ChIP-Seq_MESCs_Mouse2.03173959
28FOXM1_23109430_ChIP-Seq_U2OS_Human1.97433716
29EWS_26573619_Chip-Seq_HEK293_Human1.95746383
30SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.94884812
31NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.93674918
32NANOG_18555785_ChIP-Seq_MESCs_Mouse1.92051484
33FUS_26573619_Chip-Seq_HEK293_Human1.91314147
34CREB1_15753290_ChIP-ChIP_HEK293T_Human1.89366986
35GABP_19822575_ChIP-Seq_HepG2_Human1.87814088
36PADI4_21655091_ChIP-ChIP_MCF-7_Human1.86993349
37NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.86992356
38MYC_18940864_ChIP-ChIP_HL60_Human1.86333168
39POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.86299506
40FLI1_27457419_Chip-Seq_LIVER_Mouse1.86202509
41SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.84004110
42E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.83654265
43XRN2_22483619_ChIP-Seq_HELA_Human1.81407784
44STAT3_1855785_ChIP-Seq_MESCs_Mouse1.81326823
45POU3F2_20337985_ChIP-ChIP_501MEL_Human1.81304804
46POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.79325248
47MYCN_18555785_ChIP-Seq_MESCs_Mouse1.79230573
48DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.78804343
49VDR_23849224_ChIP-Seq_CD4+_Human1.77570596
50POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.71046063
51TTF2_22483619_ChIP-Seq_HELA_Human1.70935305
52MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.70557985
53RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.69568529
54KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.67554538
55SRF_21415370_ChIP-Seq_HL-1_Mouse1.67286174
56ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.66821333
57HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.65517996
58PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.56020518
59HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.54241633
60ZFP57_27257070_Chip-Seq_ESCs_Mouse1.53970619
61IGF1R_20145208_ChIP-Seq_DFB_Human1.52358454
62NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.51360624
63TCF3_18692474_ChIP-Seq_MEFs_Mouse1.51145729
64TCF3_18692474_ChIP-Seq_MESCs_Mouse1.50900870
65BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.50450618
66VDR_21846776_ChIP-Seq_THP-1_Human1.49603131
67NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.48203007
68NANOG_21062744_ChIP-ChIP_HESCs_Human1.45925751
69P300_19829295_ChIP-Seq_ESCs_Human1.45872641
70SOX2_18555785_ChIP-Seq_MESCs_Mouse1.45350091
71CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.43233939
72ZFX_18555785_ChIP-Seq_MESCs_Mouse1.43040875
73HOXB4_20404135_ChIP-ChIP_EML_Mouse1.42227586
74TAF15_26573619_Chip-Seq_HEK293_Human1.41941364
75GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.41669133
76NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.40297213
77FOXP3_21729870_ChIP-Seq_TREG_Human1.39771858
78DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.39754961
79POU5F1_16518401_ChIP-PET_MESCs_Mouse1.38446393
80KLF4_18555785_ChIP-Seq_MESCs_Mouse1.38356842
81PU.1_20513432_ChIP-Seq_Bcells_Mouse1.37594987
82KDM5A_27292631_Chip-Seq_BREAST_Human1.36279644
83EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.33322530
84PCGF2_27294783_Chip-Seq_ESCs_Mouse1.32895081
85POU5F1_16153702_ChIP-ChIP_HESCs_Human1.31791321
86E2F1_21310950_ChIP-Seq_MCF-7_Human1.29728098
87SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.29321148
88CTBP1_25329375_ChIP-Seq_LNCAP_Human1.28893063
89CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.27766245
90SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.26314375
91TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.26116312
92ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.25613830
93TP53_22573176_ChIP-Seq_HFKS_Human1.24494466
94CTBP2_25329375_ChIP-Seq_LNCAP_Human1.23976127
95SOX2_18692474_ChIP-Seq_MEFs_Mouse1.22194552
96POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.22147133
97MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.21545035
98TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.21285942
99YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.20130957
100GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.19904156
101MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.19727054
102MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.19637612
103PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.19413987
104CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.18845912
105CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.17476899
106CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.14708730
107OCT4_18692474_ChIP-Seq_MEFs_Mouse1.13147373
108ELK1_19687146_ChIP-ChIP_HELA_Human1.11791062
109NOTCH1_21737748_ChIP-Seq_TLL_Human1.08756519
110KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.07218991
111ESR1_15608294_ChIP-ChIP_MCF-7_Human1.06785899
112GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.06688806
113KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.06323829
114GBX2_23144817_ChIP-Seq_PC3_Human1.06136729
115ER_23166858_ChIP-Seq_MCF-7_Human1.06122048
116TET1_21451524_ChIP-Seq_MESCs_Mouse1.06032883
117ELF1_17652178_ChIP-ChIP_JURKAT_Human1.05986420
118SOX2_18692474_ChIP-Seq_MESCs_Mouse1.05934098
119CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.05820014
120ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.05344219
121FOXA1_25329375_ChIP-Seq_VCAP_Human1.04154303
122FOXA1_27270436_Chip-Seq_PROSTATE_Human1.04154303
123MYC_22102868_ChIP-Seq_BL_Human1.02597654
124ELK1_22589737_ChIP-Seq_MCF10A_Human1.02197309
125IRF1_19129219_ChIP-ChIP_H3396_Human1.01487221
126SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.01128078
127SOX2_19829295_ChIP-Seq_ESCs_Human0.99775053
128NANOG_19829295_ChIP-Seq_ESCs_Human0.99775053
129* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.99406134
130CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.98895082
131CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.98833451
132NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.98689727
133SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.98593818
134TFEB_21752829_ChIP-Seq_HELA_Human0.98320099
135IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.97238564
136CBP_20019798_ChIP-Seq_JUKART_Human0.97238564
137AR_20517297_ChIP-Seq_VCAP_Human0.96871492
138SALL1_21062744_ChIP-ChIP_HESCs_Human0.95951341
139CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.95289110
140NANOG_18692474_ChIP-Seq_MESCs_Mouse0.95012020
141HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.94969898
142EZH2_27294783_Chip-Seq_NPCs_Mouse0.93770466
143NFE2_27457419_Chip-Seq_LIVER_Mouse0.92335252
144UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.90944808
145SUZ12_27294783_Chip-Seq_NPCs_Mouse0.90124514
146NANOG_16153702_ChIP-ChIP_HESCs_Human0.90010080
147FOXA1_21572438_ChIP-Seq_LNCaP_Human0.88144646
148RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.87788204
149KLF5_20875108_ChIP-Seq_MESCs_Mouse0.87478656
150BCAT_22108803_ChIP-Seq_LS180_Human0.87110279
151TCF4_22108803_ChIP-Seq_LS180_Human0.85772540
152SOX2_16153702_ChIP-ChIP_HESCs_Human0.84526189

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication6.19451453
2MP0010030_abnormal_orbit_morphology3.58230139
3MP0010094_abnormal_chromosome_stability3.48752835
4MP0005171_absent_coat_pigmentation3.43576489
5MP0003693_abnormal_embryo_hatching3.16336089
6MP0004957_abnormal_blastocyst_morpholog3.14716403
7MP0008058_abnormal_DNA_repair2.94726662
8MP0009278_abnormal_bone_marrow2.85228896
9MP0003786_premature_aging2.68686905
10MP0003111_abnormal_nucleus_morphology2.65079936
11MP0002009_preneoplasia2.44242728
12MP0003077_abnormal_cell_cycle2.41745446
13MP0000372_irregular_coat_pigmentation2.39252901
14MP0004233_abnormal_muscle_weight2.38818776
15MP0002102_abnormal_ear_morphology2.38193400
16MP0004147_increased_porphyrin_level2.35063524
17MP0008995_early_reproductive_senescence2.30370988
18MP0003890_abnormal_embryonic-extraembry2.29943300
19MP0008875_abnormal_xenobiotic_pharmacok2.28891668
20MP0008877_abnormal_DNA_methylation2.19744420
21MP0008932_abnormal_embryonic_tissue2.18048584
22MP0003718_maternal_effect2.11645862
23MP0002938_white_spotting2.10878373
24MP0005397_hematopoietic_system_phenotyp2.09658886
25MP0001545_abnormal_hematopoietic_system2.09658886
26MP0003806_abnormal_nucleotide_metabolis2.04915167
27MP0004133_heterotaxia1.96808357
28MP0002837_dystrophic_cardiac_calcinosis1.94996454
29MP0009697_abnormal_copulation1.86010939
30MP0006072_abnormal_retinal_apoptosis1.82008901
31MP0005551_abnormal_eye_electrophysiolog1.73676947
32MP0005253_abnormal_eye_physiology1.72393958
33MP0001697_abnormal_embryo_size1.68161476
34MP0008789_abnormal_olfactory_epithelium1.64251312
35MP0005085_abnormal_gallbladder_physiolo1.63099229
36MP0002736_abnormal_nociception_after1.62391024
37MP0001529_abnormal_vocalization1.60154213
38MP0003195_calcinosis1.58914528
39MP0003119_abnormal_digestive_system1.57669926
40MP0002638_abnormal_pupillary_reflex1.56952777
41MP0002249_abnormal_larynx_morphology1.56837600
42MP0005075_abnormal_melanosome_morpholog1.56605602
43MP0005174_abnormal_tail_pigmentation1.51515976
44MP0002653_abnormal_ependyma_morphology1.51480302
45MP0001293_anophthalmia1.50556116
46MP0002282_abnormal_trachea_morphology1.50460565
47MP0002234_abnormal_pharynx_morphology1.50455939
48MP0001672_abnormal_embryogenesis/_devel1.48864564
49MP0005380_embryogenesis_phenotype1.48864564
50MP0002086_abnormal_extraembryonic_tissu1.48824859
51MP0002160_abnormal_reproductive_system1.48823768
52MP0000490_abnormal_crypts_of1.45020138
53MP0000350_abnormal_cell_proliferation1.44757971
54MP0002095_abnormal_skin_pigmentation1.42595111
55MP0002084_abnormal_developmental_patter1.42057633
56MP0002085_abnormal_embryonic_tissue1.40487239
57MP0003567_abnormal_fetal_cardiomyocyte1.40079339
58MP0010352_gastrointestinal_tract_polyps1.39862057
59MP0001730_embryonic_growth_arrest1.39390166
60MP0006292_abnormal_olfactory_placode1.39297931
61MP0002269_muscular_atrophy1.39164347
62MP0005645_abnormal_hypothalamus_physiol1.36744020
63MP0008872_abnormal_physiological_respon1.35656730
64MP0005266_abnormal_metabolism1.35315224
65MP0005389_reproductive_system_phenotype1.34293467
66MP0006035_abnormal_mitochondrial_morpho1.33768516
67MP0003011_delayed_dark_adaptation1.32213655
68MP0008007_abnormal_cellular_replicative1.31342769
69MP0004197_abnormal_fetal_growth/weight/1.28267447
70MP0003121_genomic_imprinting1.25550105
71MP0004142_abnormal_muscle_tone1.23927611
72MP0005646_abnormal_pituitary_gland1.23557906
73MP0005084_abnormal_gallbladder_morpholo1.20925368
74MP0001984_abnormal_olfaction1.20509405
75MP0003984_embryonic_growth_retardation1.20202538
76MP0002080_prenatal_lethality1.19074772
77MP0002019_abnormal_tumor_incidence1.17835789
78MP0003646_muscle_fatigue1.17108599
79MP0001968_abnormal_touch/_nociception1.16616068
80MP0003941_abnormal_skin_development1.15865265
81MP0005365_abnormal_bile_salt1.15775005
82MP0002088_abnormal_embryonic_growth/wei1.14878506
83MP0003880_abnormal_central_pattern1.13333866
84MP0003787_abnormal_imprinting1.09486895
85MP0004215_abnormal_myocardial_fiber1.09294008
86MP0002111_abnormal_tail_morphology1.09171147
87MP0005408_hypopigmentation1.08630964
88MP0000015_abnormal_ear_pigmentation1.07514397
89MP0003283_abnormal_digestive_organ1.06626258
90MP0000371_diluted_coat_color1.06390924
91MP0001485_abnormal_pinna_reflex1.03314347
92MP0001986_abnormal_taste_sensitivity1.03311198
93MP0001764_abnormal_homeostasis1.03307657
94MP0000470_abnormal_stomach_morphology1.03114549
95MP0002751_abnormal_autonomic_nervous1.02662096
96MP0000313_abnormal_cell_death1.01742162
97MP0003937_abnormal_limbs/digits/tail_de1.01584539
98MP0000631_abnormal_neuroendocrine_gland1.00936891
99MP0000647_abnormal_sebaceous_gland1.00728805
100MP0009046_muscle_twitch0.98352239
101MP0009333_abnormal_splenocyte_physiolog0.98048233
102MP0001145_abnormal_male_reproductive0.97692247
103MP0003453_abnormal_keratinocyte_physiol0.96843154
104MP0004043_abnormal_pH_regulation0.95938427
105MP0003698_abnormal_male_reproductive0.94301094
106MP0002396_abnormal_hematopoietic_system0.94211002
107MP0001324_abnormal_eye_pigmentation0.93667728
108MP0006036_abnormal_mitochondrial_physio0.93106604
109MP0000427_abnormal_hair_cycle0.92934647
110MP0002210_abnormal_sex_determination0.91256628
111MP0003136_yellow_coat_color0.91198854
112MP0000579_abnormal_nail_morphology0.88343200
113MP0005499_abnormal_olfactory_system0.87778744
114MP0005394_taste/olfaction_phenotype0.87778744
115MP0003656_abnormal_erythrocyte_physiolo0.87747290
116MP0003186_abnormal_redox_activity0.86873151
117MP0005391_vision/eye_phenotype0.85678222
118MP0005076_abnormal_cell_differentiation0.85552426
119MP0002132_abnormal_respiratory_system0.83740803
120MP0002277_abnormal_respiratory_mucosa0.83359679
121MP0005330_cardiomyopathy0.83122310
122MP0001919_abnormal_reproductive_system0.82266247
123MP0002332_abnormal_exercise_endurance0.81936758
124MP0006276_abnormal_autonomic_nervous0.79044534
125MP0000653_abnormal_sex_gland0.78951712
126MP0005410_abnormal_fertilization0.78941383
127MP0000762_abnormal_tongue_morphology0.78858161
128MP0000639_abnormal_adrenal_gland0.78299130
129MP0000358_abnormal_cell_content/0.77850060
130MP0008775_abnormal_heart_ventricle0.76553903
131MP0001119_abnormal_female_reproductive0.75672349
132MP0010307_abnormal_tumor_latency0.75234464
133MP0003252_abnormal_bile_duct0.74781533
134MP0002233_abnormal_nose_morphology0.74500988
135MP0002272_abnormal_nervous_system0.74457812
136MP0005195_abnormal_posterior_eye0.74235288
137MP0002075_abnormal_coat/hair_pigmentati0.73877224
138MP0005376_homeostasis/metabolism_phenot0.73860315
139MP0005395_other_phenotype0.73193278
140MP0001905_abnormal_dopamine_level0.73117817
141MP0002114_abnormal_axial_skeleton0.73008057
142MP0002090_abnormal_vision0.72941450
143MP0003137_abnormal_impulse_conducting0.71847470
144MP0001929_abnormal_gametogenesis0.70806769
145MP0001186_pigmentation_phenotype0.70526199
146MP0004145_abnormal_muscle_electrophysio0.70522929
147MP0000569_abnormal_digit_pigmentation0.70333588
148MP0001286_abnormal_eye_development0.69813223
149MP0009115_abnormal_fat_cell0.69644519
150MP0002932_abnormal_joint_morphology0.69509831
151MP0000689_abnormal_spleen_morphology0.67429506
152MP0003221_abnormal_cardiomyocyte_apopto0.67120047
153MP0003755_abnormal_palate_morphology0.64288854
154MP0005058_abnormal_lysosome_morphology0.64087210
155MP0001340_abnormal_eyelid_morphology0.63049409
156MP0005367_renal/urinary_system_phenotyp0.62511729
157MP0000516_abnormal_urinary_system0.62511729
158MP0003828_pulmonary_edema0.62165192
159MP0004019_abnormal_vitamin_homeostasis0.61413318
160MP0004264_abnormal_extraembryonic_tissu0.61315834
161MP0000049_abnormal_middle_ear0.60999084
162MP0009053_abnormal_anal_canal0.60694378

Predicted human phenotypes

RankGene SetZ-score
1Rectal fistula (HP:0100590)5.01871297
2Rectovaginal fistula (HP:0000143)5.01871297
3Rib fusion (HP:0000902)4.59095548
4Concave nail (HP:0001598)4.54383436
5Vaginal fistula (HP:0004320)4.38417580
6Intestinal fistula (HP:0100819)4.35275642
7Pustule (HP:0200039)4.29958981
8Facial hemangioma (HP:0000329)4.29489952
9Aplasia/Hypoplasia involving the carpal bones (HP:0006502)4.19564603
10Increased IgM level (HP:0003496)4.11613478
11Acute necrotizing encephalopathy (HP:0006965)4.08509903
12Poikiloderma (HP:0001029)3.95501445
13Tongue fasciculations (HP:0001308)3.83421558
14Mitochondrial inheritance (HP:0001427)3.82675127
15Acute encephalopathy (HP:0006846)3.76493173
16Intestinal atresia (HP:0011100)3.68922318
17Increased CSF lactate (HP:0002490)3.67620796
18Abnormal mitochondria in muscle tissue (HP:0008316)3.59939043
19Annular pancreas (HP:0001734)3.59439343
20Hypochromic microcytic anemia (HP:0004840)3.56402999
21Progressive macrocephaly (HP:0004481)3.51894522
22Muscle fibrillation (HP:0010546)3.47516382
23Abnormal hemoglobin (HP:0011902)3.45897627
24Aplasia/hypoplasia of the humerus (HP:0006507)3.44441351
25Absent radius (HP:0003974)3.39242833
26Increased hepatocellular lipid droplets (HP:0006565)3.39008573
27Absent thumb (HP:0009777)3.37546693
28Hepatocellular necrosis (HP:0001404)3.33722474
29Orthostatic hypotension (HP:0001278)3.26091221
30Alopecia of scalp (HP:0002293)3.24083621
31Short humerus (HP:0005792)3.22925271
32Lipid accumulation in hepatocytes (HP:0006561)3.22781210
33Pancreatic cysts (HP:0001737)3.19248881
34Pancreatic fibrosis (HP:0100732)3.17535093
35Absent forearm bone (HP:0003953)3.14712656
36Aplasia involving forearm bones (HP:0009822)3.14712656
37Hepatic necrosis (HP:0002605)3.14157440
38Patellar aplasia (HP:0006443)3.13407697
39Premature graying of hair (HP:0002216)3.07153326
40Molar tooth sign on MRI (HP:0002419)2.99109281
41Abnormality of midbrain morphology (HP:0002418)2.99109281
42Abnormality of alanine metabolism (HP:0010916)2.94111907
43Hyperalaninemia (HP:0003348)2.94111907
44Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.94111907
45Aplasia/Hypoplasia of the patella (HP:0006498)2.92357837
46True hermaphroditism (HP:0010459)2.90632540
47Type 2 muscle fiber atrophy (HP:0003554)2.90557222
48Squamous cell carcinoma (HP:0002860)2.89977436
49Abnormality of male internal genitalia (HP:0000022)2.89658562
50Muscle fiber atrophy (HP:0100295)2.88505199
51Aplasia/Hypoplasia of the vertebrae (HP:0008515)2.86484351
52Vertebral hypoplasia (HP:0008417)2.86484351
53Cerebral edema (HP:0002181)2.81661088
54Turricephaly (HP:0000262)2.80067094
55Increased serum lactate (HP:0002151)2.79946910
56Selective tooth agenesis (HP:0001592)2.78066954
57Methylmalonic acidemia (HP:0002912)2.73485170
58Capillary hemangiomas (HP:0005306)2.72830913
59Exertional dyspnea (HP:0002875)2.72542856
60Male infertility (HP:0003251)2.69883029
61Medial flaring of the eyebrow (HP:0010747)2.67488998
62Broad alveolar ridges (HP:0000187)2.64707419
63Chromosomal breakage induced by crosslinking agents (HP:0003221)2.64088549
64Dysautonomia (HP:0002459)2.63004028
65Ulnar bowing (HP:0003031)2.62834758
66Type I transferrin isoform profile (HP:0003642)2.60927812
67Pancreatic islet-cell hyperplasia (HP:0004510)2.60740002
68Chromsome breakage (HP:0040012)2.59184663
69Growth hormone excess (HP:0000845)2.59123608
70Meckel diverticulum (HP:0002245)2.58889345
71Aplasia/Hypoplasia of the uvula (HP:0010293)2.58689465
72Redundant skin (HP:0001582)2.57922704
73Bifid uvula (HP:0000193)2.55949762
74Short chin (HP:0000331)2.53757718
75Lactic acidosis (HP:0003128)2.51838630
76Nephronophthisis (HP:0000090)2.50902674
77Renal Fanconi syndrome (HP:0001994)2.50765221
78Hypoplasia of the radius (HP:0002984)2.49503733
793-Methylglutaconic aciduria (HP:0003535)2.48564706
80Hyperglycinemia (HP:0002154)2.45993793
81Congenital hip dislocation (HP:0001374)2.45366155
82Methylmalonic aciduria (HP:0012120)2.42488726
83Congenital, generalized hypertrichosis (HP:0004540)2.41559922
84Abnormality of chromosome stability (HP:0003220)2.39507962
85Breast hypoplasia (HP:0003187)2.39417482
86Abnormal protein glycosylation (HP:0012346)2.39335081
87Abnormal glycosylation (HP:0012345)2.39335081
88Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.39335081
89Abnormal protein N-linked glycosylation (HP:0012347)2.39335081
90Basal cell carcinoma (HP:0002671)2.35887350
91Colon cancer (HP:0003003)2.34791950
92Abnormality of serum amino acid levels (HP:0003112)2.27940003
93Birth length less than 3rd percentile (HP:0003561)2.27661290
94Premature skin wrinkling (HP:0100678)2.27379043
95Anteriorly placed anus (HP:0001545)2.27176183
96Median cleft lip (HP:0000161)2.26794111
97Hypobetalipoproteinemia (HP:0003563)2.22857190
98Large for gestational age (HP:0001520)2.22110241
99Nephrogenic diabetes insipidus (HP:0009806)2.20680067
100Respiratory failure (HP:0002878)2.20294147
101Congenital primary aphakia (HP:0007707)2.20042494
102Hypokinesia (HP:0002375)2.19798725
103Aplasia of the musculature (HP:0100854)2.19601301
104Optic disc pallor (HP:0000543)2.15066893
105Abnormality of the aortic arch (HP:0012303)2.14828080
106Abnormality of the labia minora (HP:0012880)2.14036574
107Cerebral hypomyelination (HP:0006808)2.13786968
108Abnormality of the preputium (HP:0100587)2.12787546
109Renal cortical cysts (HP:0000803)2.12404573
110Abnormality of the ileum (HP:0001549)2.10741999
111Sclerocornea (HP:0000647)2.10527879
112Gait imbalance (HP:0002141)2.08750765
113Alacrima (HP:0000522)2.08680129
114Diaphragmatic weakness (HP:0009113)2.08635452
115Aplasia/Hypoplasia involving the musculature (HP:0001460)2.08111234
116Coronal craniosynostosis (HP:0004440)2.07364213
117Volvulus (HP:0002580)2.07281961
118Congenital stationary night blindness (HP:0007642)2.06311046
119Lethargy (HP:0001254)2.06289164
120Increased intramyocellular lipid droplets (HP:0012240)2.06209027
121Abnormality of placental membranes (HP:0011409)2.06076051
122Amniotic constriction ring (HP:0009775)2.06076051
123Popliteal pterygium (HP:0009756)2.05762876
124Abnormality of the renal medulla (HP:0100957)2.05615532
125Progressive muscle weakness (HP:0003323)2.05570884
126Acute lymphatic leukemia (HP:0006721)2.04219377
127Joint stiffness (HP:0001387)2.04129385
128Abnormality of the renal cortex (HP:0011035)2.03423889
129Hypochromic anemia (HP:0001931)2.03398777
130Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.02374056
131Abnormality of methionine metabolism (HP:0010901)2.02300199
132Abnormal number of incisors (HP:0011064)2.02172920
133Abnormality of aspartate family amino acid metabolism (HP:0010899)2.00925632
134Albinism (HP:0001022)2.00831261
135Abnormality of cells of the erythroid lineage (HP:0012130)2.00157674
136Hypotrichosis (HP:0001006)1.98897206
137Choanal stenosis (HP:0000452)1.98789816
138IgA deficiency (HP:0002720)1.96516776
139Vertebral fusion (HP:0002948)1.96402943
140Aplasia/hypoplasia of the uterus (HP:0008684)1.96337752
141Gastrointestinal atresia (HP:0002589)1.96123591
142Rough bone trabeculation (HP:0100670)1.94930487
143Abnormality of the anterior horn cell (HP:0006802)1.94401183
144Degeneration of anterior horn cells (HP:0002398)1.94401183
145Abnormal biliary tract physiology (HP:0012439)1.92516593
146Bile duct proliferation (HP:0001408)1.92516593
147Type II lissencephaly (HP:0007260)1.91970111
148Hyperglycinuria (HP:0003108)1.91921398
149Decreased electroretinogram (ERG) amplitude (HP:0000654)1.91585927
150Pancytopenia (HP:0001876)1.91340561
151Hypotelorism (HP:0000601)1.90376986
152CNS demyelination (HP:0007305)1.88942361
153Genital tract atresia (HP:0001827)1.88437768
154Aplasia/Hypoplasia of the tibia (HP:0005772)1.88381926
155Reticulocytopenia (HP:0001896)1.87847225
156Aplasia/Hypoplasia of the tongue (HP:0010295)1.87447799
157Short 5th finger (HP:0009237)1.86968719
158Exercise intolerance (HP:0003546)1.86523848
159Constricted visual fields (HP:0001133)1.86031140
160Small intestinal stenosis (HP:0012848)1.85811339
161Duodenal stenosis (HP:0100867)1.85811339
162Opisthotonus (HP:0002179)1.84992205
163Abnormality of glycine metabolism (HP:0010895)1.84725093
164Abnormality of serine family amino acid metabolism (HP:0010894)1.84725093
165Abdominal situs inversus (HP:0003363)1.84538611
166Abnormality of abdominal situs (HP:0011620)1.84538611
167Short tibia (HP:0005736)1.83564766
168Megaloblastic anemia (HP:0001889)1.83194724
169Spinal muscular atrophy (HP:0007269)1.82604559
170Oral leukoplakia (HP:0002745)1.82221315
171Abnormality of the pons (HP:0007361)1.81802016
172Attenuation of retinal blood vessels (HP:0007843)1.81391716
173Sloping forehead (HP:0000340)1.79774939
174Aplasia/Hypoplasia of the sacrum (HP:0008517)1.78779884
175Abnormal number of erythroid precursors (HP:0012131)1.78708889
176Abolished electroretinogram (ERG) (HP:0000550)1.78435048
177Leukodystrophy (HP:0002415)1.77735161
178Polycythemia (HP:0001901)1.77698276
179Hypoplasia of the ulna (HP:0003022)1.77583971
180Vaginal atresia (HP:0000148)1.76823465
181Supernumerary spleens (HP:0009799)1.76802495
182Increased number of teeth (HP:0011069)1.76768634
183Amelogenesis imperfecta (HP:0000705)1.76394774
184Short thumb (HP:0009778)1.75802578
185Reduced antithrombin III activity (HP:0001976)1.75114106
186Respiratory difficulties (HP:0002880)1.74882507
187Anencephaly (HP:0002323)1.73443815
188Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.73414147
189Aplastic anemia (HP:0001915)1.73406810
190Decreased activity of mitochondrial respiratory chain (HP:0008972)1.73144698

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ICK4.59941252
2MAPK154.40256960
3DDR24.08301779
4MAP3K63.96035288
5PINK13.44705777
6MAP3K113.32859413
7NUAK13.29643998
8MATK2.82628415
9PIM22.80720405
10FRK2.72898670
11VRK22.72821863
12BMPR1B2.47504854
13FGR2.31878137
14DAPK12.28985709
15WEE12.22697568
16WNK32.14658391
17CDK72.11266249
18YES12.08697960
19BUB12.04575772
20MST42.03456427
21AKT32.00585203
22MAP4K21.97959406
23TYRO31.91618744
24TRIM281.91041525
25CSK1.81283463
26UHMK11.67758434
27PIM11.59418609
28TNIK1.57290611
29PLK11.56379391
30NME11.56296625
31PRKD21.56240889
32DYRK1B1.44543890
33ADRBK21.43452434
34BMX1.39797255
35TRPM71.38221989
36PLK41.32567664
37RPS6KL11.32545327
38RPS6KC11.32545327
39CHEK21.31586697
40DYRK31.26448604
41TAOK31.23500357
42NME21.22669936
43GRK11.19530779
44PLK21.19438287
45RPS6KA61.17545665
46CDK61.15208739
47BCR1.15052581
48TSSK61.14071619
49TAF11.13662608
50NEK11.13550265
51PDGFRA1.13218817
52CDC71.11846131
53SRPK11.05295407
54TAOK21.04722642
55BRSK21.02772233
56RPS6KB21.01572458
57CSNK1G31.01113213
58OXSR11.01063615
59ATR0.99706692
60EIF2AK30.98892368
61TGFBR10.98790214
62MAP3K40.98379561
63EIF2AK20.96794663
64MAP3K120.94827140
65MAPK110.93999429
66PDK20.93134851
67INSRR0.93133767
68MAPK130.93036531
69CSNK1G20.92330429
70EIF2AK10.91608829
71EPHA20.91409238
72STK160.90745819
73NEK20.90713570
74TESK20.90349185
75MUSK0.89652005
76AURKA0.89113298
77STK390.88984800
78MKNK20.88698314
79MKNK10.88520589
80LATS20.88336447
81CSNK2A10.83195927
82CASK0.82604874
83PHKG20.82202872
84PHKG10.82202872
85AURKB0.81243451
86CDC42BPA0.80360496
87GSK3A0.79868305
88TIE10.79742542
89CSNK1A1L0.79602978
90BCKDK0.77905678
91MAP2K70.77894709
92CDK80.76693517
93ACVR1B0.73887974
94STK38L0.71319114
95TTK0.68781444
96TXK0.68212043
97CSNK2A20.62939381
98WNK40.60961189
99CDK20.60348302
100RPS6KA10.57257079
101ADRBK10.57190380
102CDK30.57033586
103PASK0.54598081
104PRPF4B0.53877305
105ZAK0.53452599
106GRK70.53272098
107VRK10.53189821
108CSNK1G10.52896010
109ERBB30.52228867
110DYRK20.51404505
111PRKAA10.51274092
112PIK3CA0.50203149
113PRKCE0.48908293
114RPS6KB10.48681900
115TEC0.48451772
116CHEK10.47871369
117TLK10.47815133
118FLT30.47759823
119RAF10.47250915
120CDK40.44200914
121LATS10.43909461
122ATM0.43313214
123LYN0.43292015
124STK30.42676109
125CAMKK20.41621492
126MARK30.40946031
127STK240.40278846
128RPS6KA50.40072060
129MAPK40.38356110
130PRKCG0.38288366
131CSNK1A10.38176035
132KDR0.37470406
133PLK30.36340114
134RPS6KA40.36189220
135BRSK10.35962755
136CDK10.35451913
137MTOR0.35392472
138PRKCI0.34187902
139CDK190.34027751
140MAPK30.32909621
141PBK0.32667229
142CSNK1E0.32129079
143CAMK2G0.31485571
144IKBKB0.30918752
145LIMK10.29393135
146HIPK20.29073009
147PNCK0.28716314
148KIT0.28687983
149MAPKAPK50.27798343
150PAK10.27691543
151OBSCN0.27581279
152PAK30.27481681
153MAPK10.27419331
154PDK40.25472260
155PDK30.25472260
156MAP3K30.24944711
157CCNB10.24107500
158EGFR0.22219686

Predicted pathways (KEGG)

RankGene SetZ-score
1Mismatch repair_Homo sapiens_hsa034305.12783328
2DNA replication_Homo sapiens_hsa030304.61274476
3Base excision repair_Homo sapiens_hsa034104.20499657
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.46906815
5Caffeine metabolism_Homo sapiens_hsa002323.01115880
6Proteasome_Homo sapiens_hsa030502.97019210
7Nucleotide excision repair_Homo sapiens_hsa034202.96001718
8Ribosome_Homo sapiens_hsa030102.81541489
9Fatty acid biosynthesis_Homo sapiens_hsa000612.74382378
10Spliceosome_Homo sapiens_hsa030402.73867512
11Homologous recombination_Homo sapiens_hsa034402.68624383
12RNA transport_Homo sapiens_hsa030132.65096140
13RNA polymerase_Homo sapiens_hsa030202.57508644
14Fanconi anemia pathway_Homo sapiens_hsa034601.88401075
15Pyrimidine metabolism_Homo sapiens_hsa002401.84717908
16Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.84289388
17One carbon pool by folate_Homo sapiens_hsa006701.80557357
18Cell cycle_Homo sapiens_hsa041101.75667509
19Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.72596941
202-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.69507669
21mRNA surveillance pathway_Homo sapiens_hsa030151.68462970
22Folate biosynthesis_Homo sapiens_hsa007901.62509162
23Biosynthesis of amino acids_Homo sapiens_hsa012301.60903916
24Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.60432891
25p53 signaling pathway_Homo sapiens_hsa041151.50499486
26Sulfur relay system_Homo sapiens_hsa041221.44770415
27Basal transcription factors_Homo sapiens_hsa030221.37689464
28Arginine and proline metabolism_Homo sapiens_hsa003301.37128517
29RNA degradation_Homo sapiens_hsa030181.34883090
30Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.28392914
31Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.24855212
32Butanoate metabolism_Homo sapiens_hsa006501.19577649
33Peroxisome_Homo sapiens_hsa041461.14761637
34Circadian rhythm_Homo sapiens_hsa047101.13779849
35Phototransduction_Homo sapiens_hsa047441.09592078
36Fructose and mannose metabolism_Homo sapiens_hsa000511.07694521
37Tryptophan metabolism_Homo sapiens_hsa003801.06795129
38Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.06344419
39Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.04430901
40Nitrogen metabolism_Homo sapiens_hsa009101.03281235
41Glutathione metabolism_Homo sapiens_hsa004801.00275368
42Cysteine and methionine metabolism_Homo sapiens_hsa002700.99685835
43Huntingtons disease_Homo sapiens_hsa050160.94147331
44Parkinsons disease_Homo sapiens_hsa050120.94049839
45Hippo signaling pathway_Homo sapiens_hsa043900.92992990
46Oxidative phosphorylation_Homo sapiens_hsa001900.91716894
47Pentose and glucuronate interconversions_Homo sapiens_hsa000400.90182016
48Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.89870926
49Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.89517832
50Fatty acid metabolism_Homo sapiens_hsa012120.86957529
51Sulfur metabolism_Homo sapiens_hsa009200.86770517
52Non-homologous end-joining_Homo sapiens_hsa034500.85692842
53Primary bile acid biosynthesis_Homo sapiens_hsa001200.82298061
54Notch signaling pathway_Homo sapiens_hsa043300.79884608
55Hedgehog signaling pathway_Homo sapiens_hsa043400.79328728
56Purine metabolism_Homo sapiens_hsa002300.77115549
57Epstein-Barr virus infection_Homo sapiens_hsa051690.76625081
58Linoleic acid metabolism_Homo sapiens_hsa005910.76526447
59TGF-beta signaling pathway_Homo sapiens_hsa043500.76284378
60Regulation of autophagy_Homo sapiens_hsa041400.75532953
61Drug metabolism - other enzymes_Homo sapiens_hsa009830.74347968
62mTOR signaling pathway_Homo sapiens_hsa041500.72182330
63Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.70023193
64Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.69798397
65Oocyte meiosis_Homo sapiens_hsa041140.69238062
66Chemical carcinogenesis_Homo sapiens_hsa052040.66791689
67Transcriptional misregulation in cancer_Homo sapiens_hsa052020.66139170
68Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.64973116
69Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.64486942
70Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.63961035
71Selenocompound metabolism_Homo sapiens_hsa004500.63929835
72alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.63851186
73Collecting duct acid secretion_Homo sapiens_hsa049660.63537080
74Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.63008674
75Galactose metabolism_Homo sapiens_hsa000520.61348770
76Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.60958794
77Vitamin B6 metabolism_Homo sapiens_hsa007500.60418164
78Carbon metabolism_Homo sapiens_hsa012000.60307799
79Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.59647892
80Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.58489776
81Ether lipid metabolism_Homo sapiens_hsa005650.57959732
82Maturity onset diabetes of the young_Homo sapiens_hsa049500.57634244
83Adherens junction_Homo sapiens_hsa045200.56313097
84Fatty acid degradation_Homo sapiens_hsa000710.53832038
85Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.51060441
86Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.50419529
87Retinol metabolism_Homo sapiens_hsa008300.49733469
88Legionellosis_Homo sapiens_hsa051340.48944827
89Primary immunodeficiency_Homo sapiens_hsa053400.48511726
90Metabolic pathways_Homo sapiens_hsa011000.47457191
91Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.44989673
92Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.44765581
93Vitamin digestion and absorption_Homo sapiens_hsa049770.44416779
94Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.44337407
95Fatty acid elongation_Homo sapiens_hsa000620.43358561
96Basal cell carcinoma_Homo sapiens_hsa052170.43017422
97Shigellosis_Homo sapiens_hsa051310.42865819
98Wnt signaling pathway_Homo sapiens_hsa043100.42066065
99Cyanoamino acid metabolism_Homo sapiens_hsa004600.41824740
100Herpes simplex infection_Homo sapiens_hsa051680.41190739
101Steroid hormone biosynthesis_Homo sapiens_hsa001400.40165065
102beta-Alanine metabolism_Homo sapiens_hsa004100.39728894
103Olfactory transduction_Homo sapiens_hsa047400.39582658
104Arginine biosynthesis_Homo sapiens_hsa002200.38536234
105Viral carcinogenesis_Homo sapiens_hsa052030.38044476
106Longevity regulating pathway - mammal_Homo sapiens_hsa042110.37892151
107Thyroid cancer_Homo sapiens_hsa052160.37544386
108Protein export_Homo sapiens_hsa030600.36652873
109Pyruvate metabolism_Homo sapiens_hsa006200.36574659
110Propanoate metabolism_Homo sapiens_hsa006400.35765841
111Pentose phosphate pathway_Homo sapiens_hsa000300.35609452
112Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.35460523
113SNARE interactions in vesicular transport_Homo sapiens_hsa041300.35081396
114Nicotine addiction_Homo sapiens_hsa050330.34865050
115Bladder cancer_Homo sapiens_hsa052190.31921779
116Colorectal cancer_Homo sapiens_hsa052100.30629871
117Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.30461280
118Lysine degradation_Homo sapiens_hsa003100.26858146
119Alzheimers disease_Homo sapiens_hsa050100.23174611
120Asthma_Homo sapiens_hsa053100.21740782
121N-Glycan biosynthesis_Homo sapiens_hsa005100.21286203
122Cardiac muscle contraction_Homo sapiens_hsa042600.21120307
123Systemic lupus erythematosus_Homo sapiens_hsa053220.20814947
124Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.17493861
125Taste transduction_Homo sapiens_hsa047420.17254699
126HTLV-I infection_Homo sapiens_hsa051660.16861942
127Arachidonic acid metabolism_Homo sapiens_hsa005900.16397155
128Steroid biosynthesis_Homo sapiens_hsa001000.14509711
129Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.14066395
130Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.13343903
131Glycosaminoglycan degradation_Homo sapiens_hsa005310.13306045
132Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.11606817
133MicroRNAs in cancer_Homo sapiens_hsa052060.11127093

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