TECTB

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a non-collagenous glycoprotein component of the tectorial membrane, which covers the auditory hair cells in the cochlea of the inner ear. A similar protein in mouse functions in low-frequency hearing. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of somitogenesis (GO:0014807)9.39311348
2pentose metabolic process (GO:0019321)9.11853750
3glycoprotein catabolic process (GO:0006516)7.41604178
4inner ear receptor cell differentiation (GO:0060113)6.83572065
5triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.68745736
6alanine transport (GO:0032328)6.64335244
7hair cell differentiation (GO:0035315)6.54015525
8sensory perception of sound (GO:0007605)6.37417830
9sensory perception of mechanical stimulus (GO:0050954)6.26538758
10protein polyglutamylation (GO:0018095)6.16973708
11endocardial cushion morphogenesis (GO:0003203)6.07302302
12regulation of secondary heart field cardioblast proliferation (GO:0003266)5.98025103
13regulation of cardioblast proliferation (GO:0003264)5.98025103
14cartilage condensation (GO:0001502)5.92199301
15cell aggregation (GO:0098743)5.92199301
16eye photoreceptor cell differentiation (GO:0001754)5.90287765
17photoreceptor cell differentiation (GO:0046530)5.90287765
18type B pancreatic cell proliferation (GO:0044342)5.70629626
19mechanoreceptor differentiation (GO:0042490)5.48332686
20mitochondrial calcium ion transport (GO:0006851)5.47476723
21pathway-restricted SMAD protein phosphorylation (GO:0060389)5.37952641
22opioid receptor signaling pathway (GO:0038003)5.36269600
23mesenchyme morphogenesis (GO:0072132)5.21197467
24lipopolysaccharide biosynthetic process (GO:0009103)5.12238807
25cellular sodium ion homeostasis (GO:0006883)4.99039904
26aorta morphogenesis (GO:0035909)4.87953642
27glyoxylate metabolic process (GO:0046487)4.81759003
28sodium-independent organic anion transport (GO:0043252)4.70702131
29fat-soluble vitamin biosynthetic process (GO:0042362)4.70147631
30L-serine transport (GO:0015825)4.68221492
31detection of molecule of bacterial origin (GO:0032490)4.65917716
32negative regulation of fibrinolysis (GO:0051918)4.65871842
33plasma lipoprotein particle remodeling (GO:0034369)4.50452828
34protein-lipid complex remodeling (GO:0034368)4.50452828
35macromolecular complex remodeling (GO:0034367)4.50452828
36Notch signaling involved in heart development (GO:0061314)4.49966431
37lipopolysaccharide metabolic process (GO:0008653)4.34939563
38outer ear morphogenesis (GO:0042473)4.33284138
39cochlea morphogenesis (GO:0090103)4.29944371
40lateral sprouting from an epithelium (GO:0060601)4.27501928
41dorsal/ventral axis specification (GO:0009950)4.26560400
42interferon-gamma production (GO:0032609)4.20818785
43collagen metabolic process (GO:0032963)4.20090955
44collagen catabolic process (GO:0030574)4.18391855
45leukotriene biosynthetic process (GO:0019370)4.13013332
46positive regulation of Notch signaling pathway (GO:0045747)4.11882746
47regulation of alkaline phosphatase activity (GO:0010692)4.06084196
48positive regulation of granulocyte differentiation (GO:0030854)4.06057956
49response to pheromone (GO:0019236)4.05506754
50positive regulation of macrophage derived foam cell differentiation (GO:0010744)4.05132286
51tongue development (GO:0043586)4.04167058
52positive regulation of T cell cytokine production (GO:0002726)3.98972257
53multicellular organismal macromolecule metabolic process (GO:0044259)3.92924215
54establishment of planar polarity (GO:0001736)3.92346250
55establishment of tissue polarity (GO:0007164)3.92346250
56cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.90340520
57regulation of extracellular matrix disassembly (GO:0010715)3.89194535
58regulation of fibrinolysis (GO:0051917)3.88275645
59response to nitrosative stress (GO:0051409)3.86268346
60multicellular organismal catabolic process (GO:0044243)3.82872360
61SCF-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0031146)3.82288686
62myelin assembly (GO:0032288)3.81731897
63regulation of transmission of nerve impulse (GO:0051969)3.80979476
64low-density lipoprotein particle remodeling (GO:0034374)3.80580792
65regulation of heart morphogenesis (GO:2000826)3.80278866
66serine transport (GO:0032329)3.79466487
67positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.77528665
68fusion of sperm to egg plasma membrane (GO:0007342)3.77182450
69radial glial cell differentiation (GO:0060019)3.75394417
70regulation of cell proliferation involved in heart morphogenesis (GO:2000136)3.69926163
71pattern specification involved in kidney development (GO:0061004)3.68134326
72multicellular organismal metabolic process (GO:0044236)3.67125171
73heart valve morphogenesis (GO:0003179)3.59425958
74blood coagulation, intrinsic pathway (GO:0007597)3.58138397
75negative regulation of neurological system process (GO:0031645)3.56135932
76gap junction assembly (GO:0016264)3.55972772
77transmission of nerve impulse (GO:0019226)3.54359581
78regulation of sequestering of triglyceride (GO:0010889)3.53141010
79collagen fibril organization (GO:0030199)3.52947736
80positive regulation of pathway-restricted SMAD protein phosphorylation (GO:0010862)3.52851592
81regulation of corticosteroid hormone secretion (GO:2000846)3.52212075
82non-canonical Wnt signaling pathway (GO:0035567)3.50133436
83planar cell polarity pathway involved in neural tube closure (GO:0090179)3.49951486
84positive regulation of extracellular matrix organization (GO:1903055)3.47826594
85cardiac right ventricle morphogenesis (GO:0003215)3.47043526
86epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)3.45977925
87triglyceride homeostasis (GO:0070328)3.42915266
88acylglycerol homeostasis (GO:0055090)3.42915266
89protein-lipid complex subunit organization (GO:0071825)3.41506681
90positive regulation of T cell differentiation in thymus (GO:0033089)3.41445240
91plasma lipoprotein particle organization (GO:0071827)3.41157784
92negative regulation of T cell apoptotic process (GO:0070233)3.41051139
93response to host (GO:0075136)3.39596853
94response to host defenses (GO:0052200)3.39596853
95response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.39596853
96regulation of skeletal muscle cell differentiation (GO:2001014)3.37468455
97regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)3.35935677
98G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071993.35495335
99galactose catabolic process (GO:0019388)3.34619492
100diterpenoid biosynthetic process (GO:0016102)3.34021083
101regulation of protein activation cascade (GO:2000257)3.33227296
102inner ear morphogenesis (GO:0042472)3.32640730
103type B pancreatic cell development (GO:0003323)3.31313333
104intestinal cholesterol absorption (GO:0030299)3.30788997
105cardiac muscle cell proliferation (GO:0060038)3.30338117
106positive regulation of insulin-like growth factor receptor signaling pathway (GO:0043568)3.28581895
107male genitalia development (GO:0030539)3.27300414
108regulation of interleukin-13 production (GO:0032656)3.26533470
109regulation of relaxation of muscle (GO:1901077)3.25684660
110cardiac ventricle morphogenesis (GO:0003208)3.25277993
111cysteine metabolic process (GO:0006534)3.24801752
112regulation of complement activation (GO:0030449)3.23767694
113protein carboxylation (GO:0018214)3.22859582
114peptidyl-glutamic acid carboxylation (GO:0017187)3.22859582
115leukotriene metabolic process (GO:0006691)3.22617656
116negative regulation of cAMP-mediated signaling (GO:0043951)3.19654874
117endocrine hormone secretion (GO:0060986)3.18665815
118locomotory exploration behavior (GO:0035641)3.18649184
119bone trabecula formation (GO:0060346)3.17302848
120regulation of branching involved in prostate gland morphogenesis (GO:0060687)3.17120100
121negative regulation of leukocyte chemotaxis (GO:0002689)3.16783766
122regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.15773651
123reflex (GO:0060004)3.12598243
124metallo-sulfur cluster assembly (GO:0031163)3.12358717
125iron-sulfur cluster assembly (GO:0016226)3.12358717
126pharyngeal system development (GO:0060037)3.06904017
127aldehyde catabolic process (GO:0046185)3.06671982
128positive regulation of hormone biosynthetic process (GO:0046886)3.05721097
129regulation of chemokine-mediated signaling pathway (GO:0070099)3.05290550
130very-low-density lipoprotein particle assembly (GO:0034379)3.04039537
131T-helper cell differentiation (GO:0042093)3.03888040
132CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)3.03888040
133lung epithelium development (GO:0060428)3.02850997
134cardiac epithelial to mesenchymal transition (GO:0060317)3.01933491
135glial cell migration (GO:0008347)3.00449204
136response to host immune response (GO:0052572)2.99492344
137response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.99492344
138extracellular matrix disassembly (GO:0022617)2.98603562
139regulation of cholesterol esterification (GO:0010872)2.97503002
140fatty acid elongation (GO:0030497)2.95842667
141Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.95623711
142killing of cells in other organism involved in symbiotic interaction (GO:0051883)2.95517640
143disruption of cells of other organism involved in symbiotic interaction (GO:0051818)2.95517640
144regulation of digestive system process (GO:0044058)2.95465875
145somatic stem cell division (GO:0048103)2.95382080
146positive regulation of hormone metabolic process (GO:0032352)2.94296433
147ventricular septum morphogenesis (GO:0060412)2.93094313
148regulation of organ formation (GO:0003156)2.90584110
149neuroblast proliferation (GO:0007405)2.90404883
150triglyceride catabolic process (GO:0019433)2.89760845
151detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.88066660
152cell surface receptor signaling pathway involved in heart development (GO:0061311)2.87901784
153neutral lipid catabolic process (GO:0046461)2.87664684
154acylglycerol catabolic process (GO:0046464)2.87664684
155regulation of metalloenzyme activity (GO:0048552)2.87129845
156nephron tubule development (GO:0072080)2.86956333
157regulation of macrophage cytokine production (GO:0010935)2.86940422
158chondrocyte differentiation (GO:0002062)2.83964876
159heart valve formation (GO:0003188)2.82806566
160negative regulation of protein activation cascade (GO:2000258)2.81365742
1612-deoxyribonucleotide biosynthetic process (GO:0009265)2.80801653
162deoxyribose phosphate biosynthetic process (GO:0046385)2.80801653
163plasma membrane fusion (GO:0045026)2.80250315
164ectodermal placode formation (GO:0060788)2.79281264
165sodium ion homeostasis (GO:0055078)2.79018126
166regulation of cholesterol storage (GO:0010885)2.78720924
167cardiac chamber morphogenesis (GO:0003206)2.78277204
168fat-soluble vitamin catabolic process (GO:0042363)2.78060034
169vitamin catabolic process (GO:0009111)2.78060034
170regulation of establishment of planar polarity (GO:0090175)2.77181888
171artery smooth muscle contraction (GO:0014824)2.76547772
172neuronal stem cell maintenance (GO:0097150)2.74552377
173chondrocyte proliferation (GO:0035988)2.72903223
174regulation of transforming growth factor beta2 production (GO:0032909)2.72847526
175protein-lipid complex assembly (GO:0065005)2.71794938
176microglial cell activation (GO:0001774)2.71053361
177peristalsis (GO:0030432)2.70601174
178middle ear morphogenesis (GO:0042474)2.70573107
179lipoprotein metabolic process (GO:0042157)2.69063863
180G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.68705833
181glutamate metabolic process (GO:0006536)2.66119344
182regulation of plasminogen activation (GO:0010755)2.65698551
183tonic smooth muscle contraction (GO:0014820)2.65130536
184regulation of cilium movement (GO:0003352)2.64285019
185regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)2.64063306
186plasma lipoprotein particle assembly (GO:0034377)2.62404980
187protein prenylation (GO:0018342)2.61618999
188prenylation (GO:0097354)2.61618999
189regulation of energy homeostasis (GO:2000505)2.61218158
190alpha-beta T cell differentiation involved in immune response (GO:0002293)2.60552334
191alpha-beta T cell activation involved in immune response (GO:0002287)2.60552334
192T cell differentiation involved in immune response (GO:0002292)2.60552334
193positive regulation of lipid storage (GO:0010884)2.60507268
194arginine catabolic process (GO:0006527)2.58639138
195proline metabolic process (GO:0006560)2.58499691
196positive regulation of hemostasis (GO:1900048)2.55007600
197positive regulation of blood coagulation (GO:0030194)2.55007600
198positive regulation of male gonad development (GO:2000020)2.52499699
199auditory receptor cell differentiation (GO:0042491)10.2815289

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human7.92533591
2TP63_17297297_ChIP-ChIP_HaCaT_Human5.32725263
3CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human4.14326282
4GLI1_17442700_ChIP-ChIP_MESCs_Mouse4.02043974
5FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.23868535
6ZFP322A_24550733_ChIP-Seq_MESCs_Mouse3.18382745
7TAF15_26573619_Chip-Seq_HEK293_Human3.03702045
8FLI1_27457419_Chip-Seq_LIVER_Mouse2.89851741
9ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.80374965
10IRF8_21731497_ChIP-ChIP_J774_Mouse2.75128811
11STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.73023804
12IGF1R_20145208_ChIP-Seq_DFB_Human2.70867602
13AR_21572438_ChIP-Seq_LNCaP_Human2.61825799
14PCGF2_27294783_Chip-Seq_ESCs_Mouse2.58938085
15RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.56820439
16ESR1_21235772_ChIP-Seq_MCF-7_Human2.56134333
17CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.49045952
18ERG_21242973_ChIP-ChIP_JURKAT_Human2.37977039
19RNF2_18974828_ChIP-Seq_MESCs_Mouse2.31398119
20EZH2_18974828_ChIP-Seq_MESCs_Mouse2.31398119
21JARID2_20064375_ChIP-Seq_MESCs_Mouse2.29762815
22SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.28511510
23PCGF2_27294783_Chip-Seq_NPCs_Mouse2.22660245
24SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.22451771
25EGR1_23403033_ChIP-Seq_LIVER_Mouse2.19345909
26ESR2_21235772_ChIP-Seq_MCF-7_Human2.16495906
27SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.07502948
28RUNX_20019798_ChIP-Seq_JUKART_Human2.02318817
29CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.98177586
30IRF1_19129219_ChIP-ChIP_H3396_Human1.98167898
31EED_16625203_ChIP-ChIP_MESCs_Mouse1.98012645
32EP300_21415370_ChIP-Seq_HL-1_Mouse1.97709451
33EZH2_27294783_Chip-Seq_ESCs_Mouse1.95223570
34ZNF217_24962896_ChIP-Seq_MCF-7_Human1.91826049
35RNF2_27304074_Chip-Seq_ESCs_Mouse1.89597545
36SMAD_19615063_ChIP-ChIP_OVARY_Human1.88471461
37EZH2_22144423_ChIP-Seq_EOC_Human1.87260614
38KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.86962276
39KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.86962276
40KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.86962276
41SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.86465450
42IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.86145564
43CBP_20019798_ChIP-Seq_JUKART_Human1.86145564
44ZFP57_27257070_Chip-Seq_ESCs_Mouse1.86021928
45CLOCK_20551151_ChIP-Seq_293T_Human1.85919905
46ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.85323168
47SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.84154933
48WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.84106620
49SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.83274247
50SUZ12_27294783_Chip-Seq_ESCs_Mouse1.82669746
51AHR_22903824_ChIP-Seq_MCF-7_Human1.78099292
52SUZ12_27294783_Chip-Seq_NPCs_Mouse1.77738350
53VDR_22108803_ChIP-Seq_LS180_Human1.73095196
54JARID2_20075857_ChIP-Seq_MESCs_Mouse1.72262870
55* LXR_22158963_ChIP-Seq_LIVER_Mouse1.71810575
56ARNT_22903824_ChIP-Seq_MCF-7_Human1.71729305
57POU3F2_20337985_ChIP-ChIP_501MEL_Human1.67905154
58* FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.66986668
59TCF4_18268006_ChIP-ChIP_LS174T_Human1.62493605
60NFE2_27457419_Chip-Seq_LIVER_Mouse1.61680224
61CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.53928208
62SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.52602534
63RING1B_27294783_Chip-Seq_ESCs_Mouse1.51991103
64MTF2_20144788_ChIP-Seq_MESCs_Mouse1.50213076
65* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.50192697
66PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.50124654
67NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.48788677
68GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.48530979
69RXR_22158963_ChIP-Seq_LIVER_Mouse1.47756464
70EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.44624726
71BCAT_22108803_ChIP-Seq_LS180_Human1.40731258
72PPARA_22158963_ChIP-Seq_LIVER_Mouse1.38156638
73HTT_18923047_ChIP-ChIP_STHdh_Human1.37037708
74GBX2_23144817_ChIP-Seq_PC3_Human1.36627635
75RXR_22108803_ChIP-Seq_LS180_Human1.36579209
76TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.36553641
77EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.36523530
78TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.36394381
79HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.35876986
80MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.35021671
81EZH2_27304074_Chip-Seq_ESCs_Mouse1.34655973
82EZH2_27294783_Chip-Seq_NPCs_Mouse1.34024887
83SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.32176935
84RING1B_27294783_Chip-Seq_NPCs_Mouse1.30825708
85EGR1_19032775_ChIP-ChIP_M12_Human1.30477593
86SMAD3_21741376_ChIP-Seq_EPCs_Human1.28736187
87RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.28300427
88* FOXA2_19822575_ChIP-Seq_HepG2_Human1.28144706
89SMAD4_21741376_ChIP-Seq_EPCs_Human1.27194749
90TP53_20018659_ChIP-ChIP_R1E_Mouse1.25674788
91FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.25277660
92KLF5_20875108_ChIP-Seq_MESCs_Mouse1.24080760
93P300_19829295_ChIP-Seq_ESCs_Human1.23348862
94UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.23084528
95* SOX2_19829295_ChIP-Seq_ESCs_Human1.22886047
96* NANOG_19829295_ChIP-Seq_ESCs_Human1.22886047
97NMYC_18555785_Chip-Seq_ESCs_Mouse1.21851900
98PIAS1_25552417_ChIP-Seq_VCAP_Human1.20338485
99CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.19848393
100LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.19630230
101KLF4_18555785_Chip-Seq_ESCs_Mouse1.19587883
102FOXO3_23340844_ChIP-Seq_DLD1_Human1.17591866
103OCT4_18555785_Chip-Seq_ESCs_Mouse1.17466050
104CTBP1_25329375_ChIP-Seq_LNCAP_Human1.16799596
105NANOG_18555785_Chip-Seq_ESCs_Mouse1.15278715
106SMAD4_21741376_ChIP-Seq_HESCs_Human1.15232837
107NOTCH1_21737748_ChIP-Seq_TLL_Human1.14738875
108AR_20517297_ChIP-Seq_VCAP_Human1.14640125
109STAT3_18555785_Chip-Seq_ESCs_Mouse1.13958929
110BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.12772511
111KDM2B_26808549_Chip-Seq_K562_Human1.12327372
112SOX2_18555785_Chip-Seq_ESCs_Mouse1.12030459
113ISL1_27105846_Chip-Seq_CPCs_Mouse1.11424712
114AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.10862633
115EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.10853547
116P53_22387025_ChIP-Seq_ESCs_Mouse1.10635002
117ESR1_20079471_ChIP-ChIP_T-47D_Human1.10366337
118LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.09592529
119ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.09531937
120SMAD4_21799915_ChIP-Seq_A2780_Human1.09102231
121RUNX1_27514584_Chip-Seq_MCF-7_Human1.08747097
122SOX2_21211035_ChIP-Seq_LN229_Gbm1.08594435
123TP53_22573176_ChIP-Seq_HFKS_Human1.08287404
124ZFP281_18757296_ChIP-ChIP_E14_Mouse1.08168379
125E2F1_18555785_Chip-Seq_ESCs_Mouse1.08066505
126CDX2_20551321_ChIP-Seq_CACO-2_Human1.08047720
127AR_25329375_ChIP-Seq_VCAP_Human1.07864528
128SUZ12_18555785_Chip-Seq_ESCs_Mouse1.07752883
129GATA3_24758297_ChIP-Seq_MCF-7_Human1.07105174
130CTCF_18555785_Chip-Seq_ESCs_Mouse1.06180494
131CTBP2_25329375_ChIP-Seq_LNCAP_Human1.05794869
132ZFP281_27345836_Chip-Seq_ESCs_Mouse1.04873906
133SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.04844719
134* POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.03851761
135* TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03851761
136PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.03287048
137SMAD3_21741376_ChIP-Seq_HESCs_Human1.02758333
138FOXM1_26456572_ChIP-Seq_MCF-7_Human1.02075735
139TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.01991833
140* AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.01864805
141SMAD1_18555785_Chip-Seq_ESCs_Mouse1.01408043
142KDM2B_26808549_Chip-Seq_DND41_Human1.00386220
143OCT1_27270436_Chip-Seq_PROSTATE_Human1.00069765
144GATA3_27048872_Chip-Seq_THYMUS_Human0.99680654
145MYB_26560356_Chip-Seq_TH2_Human0.98969661
146STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.98792117
147EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.98541101
148P300_18555785_Chip-Seq_ESCs_Mouse0.98469784
149JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.98270264
150THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.98084402
151PU1_27457419_Chip-Seq_LIVER_Mouse0.97673484
152SOX2_20726797_ChIP-Seq_SW620_Human0.97668209
153TP53_18474530_ChIP-ChIP_U2OS_Human0.97564115
154CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.97549931
155DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.97431713
156OCT4_21477851_ChIP-Seq_ESCs_Mouse0.96968332
157TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.96509458
158KLF5_25053715_ChIP-Seq_YYC3_Human0.95520564
159VDR_24787735_ChIP-Seq_THP-1_Human0.95384721
160SOX9_24532713_ChIP-Seq_HFSC_Mouse0.93443580
161SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.92179711
162KDM2B_26808549_Chip-Seq_SUP-B15_Human0.91968663
163LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91874850
164CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.91425494
165IKZF1_21737484_ChIP-ChIP_HCT116_Human0.89321534
166PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.88644253
167CDX2_19796622_ChIP-Seq_MESCs_Mouse0.88436941
168KDM2B_26808549_Chip-Seq_JURKAT_Human0.88359539
169SMAD3_21741376_ChIP-Seq_ESCs_Human0.87849954
170RACK7_27058665_Chip-Seq_MCF-7_Human0.86973123
171WT1_19549856_ChIP-ChIP_CCG9911_Human0.85950676
172TOP2B_26459242_ChIP-Seq_MCF-7_Human0.85616899
173NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.84817713
174FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.84118906
175RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.83394102
176TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.83383120
177* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.83291427
178NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.82416578
179NRF2_20460467_ChIP-Seq_MEFs_Mouse0.82416578
180ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.81894762
181* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.81683882
182P300_27058665_Chip-Seq_ZR-75-30cells_Human0.81642757
183SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.81293272
184TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.80998439
185PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.80277003
186DROSHA_22980978_ChIP-Seq_HELA_Human0.80108224

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003879_abnormal_hair_cell9.37944053
2MP0003183_abnormal_peptide_metabolism6.72132981
3MP0005377_hearing/vestibular/ear_phenot6.62513662
4MP0003878_abnormal_ear_physiology6.62513662
5MP0001485_abnormal_pinna_reflex5.78153337
6* MP0001963_abnormal_hearing_physiology4.24975818
7* MP0000026_abnormal_inner_ear4.11616565
8MP0001984_abnormal_olfaction3.98982610
9MP0008260_abnormal_autophagy3.52770510
10MP0004885_abnormal_endolymph3.04765596
11MP0002163_abnormal_gland_morphology2.79022200
12MP0005248_abnormal_Harderian_gland2.60160515
13MP0003195_calcinosis2.52084710
14MP0005379_endocrine/exocrine_gland_phen2.35474975
15MP0010329_abnormal_lipoprotein_level2.32872292
16MP0005645_abnormal_hypothalamus_physiol2.32820644
17MP0003941_abnormal_skin_development2.19458986
18MP0005085_abnormal_gallbladder_physiolo2.17776695
19MP0005551_abnormal_eye_electrophysiolog2.15746803
20MP0003011_delayed_dark_adaptation2.12713854
21MP0009780_abnormal_chondrocyte_physiolo2.11795127
22MP0000566_synostosis2.09228969
23MP0009697_abnormal_copulation2.01380793
24MP0000049_abnormal_middle_ear2.00438902
25MP0003942_abnormal_urinary_system1.89624843
26MP0010386_abnormal_urinary_bladder1.85039364
27MP0002139_abnormal_hepatobiliary_system1.81220365
28MP0010234_abnormal_vibrissa_follicle1.80658021
29MP0003705_abnormal_hypodermis_morpholog1.80557539
30MP0001529_abnormal_vocalization1.79158194
31MP0000534_abnormal_ureter_morphology1.78975254
32MP0005171_absent_coat_pigmentation1.74743034
33MP0005410_abnormal_fertilization1.73041225
34MP0005508_abnormal_skeleton_morphology1.71818550
35MP0005310_abnormal_salivary_gland1.71742191
36MP0008875_abnormal_xenobiotic_pharmacok1.67724950
37MP0009785_altered_susceptibility_to1.65439154
38MP0002932_abnormal_joint_morphology1.65194142
39MP0010678_abnormal_skin_adnexa1.63860486
40MP0005332_abnormal_amino_acid1.60259035
41MP0005360_urolithiasis1.59049833
42MP0002249_abnormal_larynx_morphology1.56983633
43MP0004134_abnormal_chest_morphology1.53526393
44MP0001764_abnormal_homeostasis1.52055065
45MP0002653_abnormal_ependyma_morphology1.51865386
46MP0000383_abnormal_hair_follicle1.50848677
47MP0008775_abnormal_heart_ventricle1.50287308
48MP0004264_abnormal_extraembryonic_tissu1.46902445
49MP0003938_abnormal_ear_development1.44568875
50MP0005671_abnormal_response_to1.42115169
51MP0005623_abnormal_meninges_morphology1.41946036
52MP0008438_abnormal_cutaneous_collagen1.39591052
53MP0000579_abnormal_nail_morphology1.39239315
54MP0001849_ear_inflammation1.38973312
55MP0010030_abnormal_orbit_morphology1.36666472
56MP0001756_abnormal_urination1.30841190
57MP0003646_muscle_fatigue1.29762018
58MP0009384_cardiac_valve_regurgitation1.27057839
59MP0004272_abnormal_basement_membrane1.22647999
60MP0000762_abnormal_tongue_morphology1.21821440
61MP0003122_maternal_imprinting1.20798566
62MP0001486_abnormal_startle_reflex1.20503061
63MP0000163_abnormal_cartilage_morphology1.20474918
64MP0008057_abnormal_DNA_replication1.20453372
65MP0002089_abnormal_postnatal_growth/wei1.19509539
66MP0009046_muscle_twitch1.17658353
67MP0009053_abnormal_anal_canal1.16089180
68MP0005584_abnormal_enzyme/coenzyme_acti1.15401347
69MP0002282_abnormal_trachea_morphology1.13332134
70MP0001346_abnormal_lacrimal_gland1.13218690
71MP0004742_abnormal_vestibular_system1.10536650
72MP0002009_preneoplasia1.10055400
73MP0002115_abnormal_skeleton_extremities1.06578806
74MP0001299_abnormal_eye_distance/1.05409104
75MP0003724_increased_susceptibility_to1.04280800
76MP0005167_abnormal_blood-brain_barrier1.04228188
77MP0006054_spinal_hemorrhage1.04174487
78MP0002233_abnormal_nose_morphology1.01957128
79MP0008872_abnormal_physiological_respon1.01174052
80MP0002933_joint_inflammation1.00905007
81MP0002116_abnormal_craniofacial_bone0.99620511
82MP0002102_abnormal_ear_morphology0.99109633
83MP0001286_abnormal_eye_development0.97964356
84MP0004019_abnormal_vitamin_homeostasis0.97079055
85MP0003115_abnormal_respiratory_system0.96546369
86MP0005365_abnormal_bile_salt0.96061125
87MP0003172_abnormal_lysosome_physiology0.95529257
88MP0005376_homeostasis/metabolism_phenot0.94263617
89MP0000428_abnormal_craniofacial_morphol0.92764158
90MP0001666_abnormal_nutrient_absorption0.91441102
91MP0003300_gastrointestinal_ulcer0.90465085
92MP0000249_abnormal_blood_vessel0.90253343
93MP0005390_skeleton_phenotype0.89176296
94MP0003136_yellow_coat_color0.88662187
95MP0003868_abnormal_feces_composition0.88347248
96MP0005166_decreased_susceptibility_to0.87620249
97MP0000639_abnormal_adrenal_gland0.86186100
98MP0004924_abnormal_behavior0.85000496
99MP0005386_behavior/neurological_phenoty0.85000496
100MP0005275_abnormal_skin_tensile0.84926512
101MP0002752_abnormal_somatic_nervous0.83459448
102MP0001177_atelectasis0.83280605
103MP0004484_altered_response_of0.83057884
104MP0002127_abnormal_cardiovascular_syste0.82908133
105MP0000685_abnormal_immune_system0.82819238
106MP0005075_abnormal_melanosome_morpholog0.82473851
107MP0002111_abnormal_tail_morphology0.82157224
108MP0002118_abnormal_lipid_homeostasis0.81854387
109MP0000613_abnormal_salivary_gland0.81545388
110MP0000537_abnormal_urethra_morphology0.81522748
111MP0002277_abnormal_respiratory_mucosa0.80982095
112MP0003633_abnormal_nervous_system0.79992058
113MP0009250_abnormal_appendicular_skeleto0.78861431
114MP0004130_abnormal_muscle_cell0.77372532
115MP0003075_altered_response_to0.76745859
116MP0005164_abnormal_response_to0.75758815
117MP0003252_abnormal_bile_duct0.75715099
118MP0003656_abnormal_erythrocyte_physiolo0.75486644
119MP0005266_abnormal_metabolism0.75250060
120MP0000003_abnormal_adipose_tissue0.75038522
121MP0002876_abnormal_thyroid_physiology0.73116780
122MP0001958_emphysema0.71417915
123MP0002098_abnormal_vibrissa_morphology0.71253035
124MP0001970_abnormal_pain_threshold0.70099435
125MP0005319_abnormal_enzyme/_coenzyme0.67209641
126MP0002971_abnormal_brown_adipose0.66388882
127MP0002113_abnormal_skeleton_development0.65375972
128MP0002109_abnormal_limb_morphology0.65371243
129MP0010368_abnormal_lymphatic_system0.65092316
130MP0005253_abnormal_eye_physiology0.64905326
131MP0004142_abnormal_muscle_tone0.64868946
132MP0002796_impaired_skin_barrier0.64766244
133MP0003283_abnormal_digestive_organ0.63497097
134MP0002148_abnormal_hypersensitivity_rea0.63345920
135MP0000609_abnormal_liver_physiology0.63083572
136MP0002269_muscular_atrophy0.61928862
137MP0002419_abnormal_innate_immunity0.61924851
138MP0002972_abnormal_cardiac_muscle0.61862198
139MP0003119_abnormal_digestive_system0.60044710
140MP0001905_abnormal_dopamine_level0.59944911
141MP0003690_abnormal_glial_cell0.59841013
142MP0009643_abnormal_urine_homeostasis0.59313319
143MP0006138_congestive_heart_failure0.59046968
144MP0005464_abnormal_platelet_physiology0.58520772
145MP0001340_abnormal_eyelid_morphology0.58220655
146MP0000733_abnormal_muscle_development0.58092352
147MP0002136_abnormal_kidney_physiology0.57984266
148MP0001853_heart_inflammation0.57698465
149MP0005451_abnormal_body_composition0.56996535
150MP0005375_adipose_tissue_phenotype0.56951893
151MP0004858_abnormal_nervous_system0.56860603
152MP0002751_abnormal_autonomic_nervous0.56659184
153MP0003567_abnormal_fetal_cardiomyocyte0.56577297
154MP0004215_abnormal_myocardial_fiber0.56155456
155MP0002938_white_spotting0.56032546
156MP0008469_abnormal_protein_level0.56012626
157MP0004883_abnormal_blood_vessel0.55970257
158MP0003755_abnormal_palate_morphology0.55818446
159MP0003453_abnormal_keratinocyte_physiol0.55205093
160MP0005195_abnormal_posterior_eye0.55089393
161MP0002229_neurodegeneration0.54202463
162MP0005408_hypopigmentation0.54027804
163MP0002837_dystrophic_cardiac_calcinosis0.53922822
164MP0003329_amyloid_beta_deposits0.53786780
165MP0002184_abnormal_innervation0.53494832
166MP0001533_abnormal_skeleton_physiology0.53356594
167MP0008789_abnormal_olfactory_epithelium0.53347561
168MP0003935_abnormal_craniofacial_develop0.52625646
169MP0000516_abnormal_urinary_system0.52482005
170MP0005367_renal/urinary_system_phenotyp0.52482005
171MP0000432_abnormal_head_morphology0.49600121
172* MP0002272_abnormal_nervous_system0.48143497
173MP0002060_abnormal_skin_morphology0.47321968
174MP0005503_abnormal_tendon_morphology0.46843479
175MP0002882_abnormal_neuron_morphology0.45818164
176MP0002896_abnormal_bone_mineralization0.45722256
177MP0002177_abnormal_outer_ear0.44598556
178MP0002092_abnormal_eye_morphology0.43595699
179MP0001293_anophthalmia0.41960740
180MP0002697_abnormal_eye_size0.40780433
181MP0000604_amyloidosis0.39947413
182MP0000631_abnormal_neuroendocrine_gland0.39847479
183MP0000767_abnormal_smooth_muscle0.39419901
184MP0004381_abnormal_hair_follicle0.39407382
185MP0001270_distended_abdomen0.38445204
186MP0000778_abnormal_nervous_system0.38357804

Predicted human phenotypes

RankGene SetZ-score
1Aplasia/Hypoplasia of the pubic bone (HP:0009104)7.70077762
2Mixed hearing impairment (HP:0000410)7.59873832
3Hypoplastic ischia (HP:0003175)7.23746748
4Pigmentary retinal degeneration (HP:0001146)7.06504079
5Vitreoretinal degeneration (HP:0000655)7.02071297
6Severe Myopia (HP:0011003)6.80301727
7Abnormality of the ischium (HP:0003174)6.37448872
8Irregular epiphyses (HP:0010582)6.03269845
9Mild short stature (HP:0003502)5.41220724
10Hyperlipoproteinemia (HP:0010980)5.38578171
11Epidermoid cyst (HP:0200040)5.35928925
12Bell-shaped thorax (HP:0001591)4.99553103
13Unilateral renal agenesis (HP:0000122)4.95169343
14Abnormality of the pubic bones (HP:0003172)4.77680516
15Deep venous thrombosis (HP:0002625)4.66741636
16Xanthomatosis (HP:0000991)4.55828592
17Enlarged epiphyses (HP:0010580)4.45709092
18Aplastic anemia (HP:0001915)4.43138804
19Broad alveolar ridges (HP:0000187)4.36069867
20Vertebral clefting (HP:0008428)4.31300387
21Absent epiphyses (HP:0010577)4.28128018
22Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)4.28128018
23Bilateral microphthalmos (HP:0007633)4.13741687
24Flat acetabular roof (HP:0003180)4.13554541
25Hypercholesterolemia (HP:0003124)4.10714591
26Osteoarthritis (HP:0002758)4.01533919
27Anomalous pulmonary venous return (HP:0010772)3.98788864
28Abnormality of the vitreous humor (HP:0004327)3.97351711
29Prolonged partial thromboplastin time (HP:0003645)3.80547326
30Genu varum (HP:0002970)3.73717081
31Beaking of vertebral bodies (HP:0004568)3.68191805
32Abnormality of liposaccharide metabolism (HP:0010968)3.64280841
33Abnormality of glycosphingolipid metabolism (HP:0004343)3.64280841
34Abnormality of glycolipid metabolism (HP:0010969)3.64280841
35Diastasis recti (HP:0001540)3.60295788
36Flattened epiphyses (HP:0003071)3.58443931
37Protuberant abdomen (HP:0001538)3.55955713
38Genetic anticipation (HP:0003743)3.51680262
39Hypobetalipoproteinemia (HP:0003563)3.49745845
40Glossoptosis (HP:0000162)3.49059544
41Hypoproteinemia (HP:0003075)3.46612014
42Myocardial infarction (HP:0001658)3.44973711
43Abnormality of the pulmonary veins (HP:0011718)3.44704288
44Skin nodule (HP:0200036)3.40282691
45Recurrent corneal erosions (HP:0000495)3.37786261
46Abnormality of the lumbar spine (HP:0100712)3.36324569
47Flared iliac wings (HP:0002869)3.35662652
48Aplasia/Hypoplasia of the fovea (HP:0008060)3.35194906
49Hypoplasia of the fovea (HP:0007750)3.35194906
50Small epiphyses (HP:0010585)3.32312939
51Lip pit (HP:0100267)3.30101370
52Exostoses (HP:0100777)3.29477019
53J-shaped sella turcica (HP:0002680)3.27206424
54Thickened calvaria (HP:0002684)3.27065022
55Arterial tortuosity (HP:0005116)3.24475470
56Platyspondyly (HP:0000926)3.20327953
57Fat malabsorption (HP:0002630)3.13577625
58Abnormal vertebral ossification (HP:0100569)3.13425714
59Broad ribs (HP:0000885)3.06688207
60Thoracolumbar scoliosis (HP:0002944)3.05452227
61Acanthocytosis (HP:0001927)3.03947229
62Synostosis involving the elbow (HP:0003938)3.02692323
63Humeroradial synostosis (HP:0003041)3.02692323
64Sprengel anomaly (HP:0000912)3.00491156
65Pancreatic islet-cell hyperplasia (HP:0004510)2.98484027
66Joint hemorrhage (HP:0005261)2.96998186
67Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.96569419
68Morphological abnormality of the middle ear (HP:0008609)2.95486982
69Fused cervical vertebrae (HP:0002949)2.93956691
70Nausea (HP:0002018)2.93873321
71Palpebral edema (HP:0100540)2.92346986
72Broad face (HP:0000283)2.91113728
73Morphological abnormality of the inner ear (HP:0011390)2.90110074
74Vascular tortuosity (HP:0004948)2.83329259
75Dysostosis multiplex (HP:0000943)2.81758018
76Multifactorial inheritance (HP:0001426)2.81380350
77Carpal bone hypoplasia (HP:0001498)2.78299260
78Abnormal auditory evoked potentials (HP:0006958)2.78102855
79Abnormality of the fovea (HP:0000493)2.76945876
80Aortic regurgitation (HP:0001659)2.72925202
81Purpura (HP:0000979)2.72550996
82Abnormality of monocarboxylic acid metabolism (HP:0010996)2.71580773
83Synostosis of carpal bones (HP:0005048)2.71303917
84Recurrent bronchitis (HP:0002837)2.68193289
85Autoimmune hemolytic anemia (HP:0001890)2.67734032
86Alopecia of scalp (HP:0002293)2.67146531
87Absent eyelashes (HP:0000561)2.66184264
88Delayed epiphyseal ossification (HP:0002663)2.66004867
89Intrahepatic cholestasis (HP:0001406)2.59147642
90Abnormality of methionine metabolism (HP:0010901)2.52547796
91Pathologic fracture (HP:0002756)2.51662679
92Aplasia/Hypoplasia of the macula (HP:0008059)2.50494384
93Menorrhagia (HP:0000132)2.49256405
94Large for gestational age (HP:0001520)2.47267808
95Steatorrhea (HP:0002570)2.46681418
96Thyroiditis (HP:0100646)2.45194393
97Complement deficiency (HP:0004431)2.43824348
98Increased mean platelet volume (HP:0011877)2.43581238
99Abnormality of the intervertebral disk (HP:0005108)2.43463874
100Aplasia/Hypoplasia affecting the retina (HP:0008061)2.42024785
101Abnormality of pyrimidine metabolism (HP:0004353)2.41922133
102Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.41513426
103Reduced antithrombin III activity (HP:0001976)2.40603558
104Conjugated hyperbilirubinemia (HP:0002908)2.30668453
105Renal dysplasia (HP:0000110)2.28833565
106Abnormality of the wing of the ilium (HP:0011867)2.28785900
107Micromelia (HP:0002983)2.28777474
108Flared metaphyses (HP:0003015)2.28349154
109Congenital stationary night blindness (HP:0007642)2.23500666
110Lack of skin elasticity (HP:0100679)2.23459413
111Aplasia/Hypoplasia involving the pelvis (HP:0009103)2.22835615
112Severe combined immunodeficiency (HP:0004430)2.22206594
113Congenital sensorineural hearing impairment (HP:0008527)2.21471768
114Abnormality of B cell number (HP:0010975)2.17671978
115Autoimmune thrombocytopenia (HP:0001973)2.17262936
116Acne (HP:0001061)2.16816413
117Rhizomelia (HP:0008905)2.16249556
118Keratoconjunctivitis sicca (HP:0001097)2.16108365
119Gingival bleeding (HP:0000225)2.13657217
120Abnormality of midbrain morphology (HP:0002418)2.12059725
121Molar tooth sign on MRI (HP:0002419)2.12059725
122Abnormality of aspartate family amino acid metabolism (HP:0010899)2.11712454
123Alacrima (HP:0000522)2.11069297
124Hypoplasia of the thymus (HP:0000778)2.10478832
125Progressive cerebellar ataxia (HP:0002073)2.09787787
126T lymphocytopenia (HP:0005403)2.09435774
127Toxemia of pregnancy (HP:0100603)2.08882843
128Abnormal platelet volume (HP:0011876)2.08266948
129Thoracic kyphosis (HP:0002942)2.07350120
13011 pairs of ribs (HP:0000878)2.06839658
131Striae distensae (HP:0001065)2.06403395
132Systemic lupus erythematosus (HP:0002725)2.05371147
133Type I transferrin isoform profile (HP:0003642)2.02982340
134Retinopathy (HP:0000488)2.02400122
135B lymphocytopenia (HP:0010976)2.02233035
136Partial duplication of thumb phalanx (HP:0009944)2.00715252
137Abnormality of the common coagulation pathway (HP:0010990)2.00560370
138Epiphyseal dysplasia (HP:0002656)11.9467656
139Increased circulating renin level (HP:0000848)1.99956077
140Abnormality of the alveolar ridges (HP:0006477)1.99906149
141Oligodactyly (HP:0012165)1.97999450
142Xerostomia (HP:0000217)1.97633024
143Glomerulonephritis (HP:0000099)1.97225596
144Abnormality of T cell number (HP:0011839)1.97182963
145Oral leukoplakia (HP:0002745)1.96984918
146Aplasia involving bones of the extremities (HP:0009825)1.96163402
147Aplasia involving bones of the upper limbs (HP:0009823)1.96163402
148Aplasia of the phalanges of the hand (HP:0009802)1.96163402
149Mucopolysacchariduria (HP:0008155)1.93206319
150Urinary glycosaminoglycan excretion (HP:0003541)1.93206319
151Abnormality of glutamine family amino acid metabolism (HP:0010902)1.91089494
152Knee flexion contracture (HP:0006380)1.90110250
153Carpal synostosis (HP:0009702)1.89610749
154Preauricular skin tag (HP:0000384)1.87512360
155Down-sloping shoulders (HP:0200021)1.87105540
156Keratoconjunctivitis (HP:0001096)1.87084124
157Hepatosplenomegaly (HP:0001433)1.87028455
158Alkalosis (HP:0001948)1.86934774
159Scanning speech (HP:0002168)1.86828200
160Hoarse voice (HP:0001609)1.86479527
161Hydroxyprolinuria (HP:0003080)1.85244411
162Abnormality of proline metabolism (HP:0010907)1.85244411
163Hypoplastic scapulae (HP:0000882)1.84918312
164Aplasia/Hypoplasia of the scapulae (HP:0006713)1.84918312
165Craniofacial hyperostosis (HP:0004493)1.84610160
166Periauricular skin pits (HP:0100277)1.83794654
167Preauricular pit (HP:0004467)1.83794654
168Menstrual irregularities (HP:0000858)1.81973358
169Poikilocytosis (HP:0004447)1.81477829
170Partial duplication of the phalanx of hand (HP:0009999)1.80311608
171Hypoplastic ilia (HP:0000946)1.79242230
172Bulbous nose (HP:0000414)1.77573649
173Amniotic constriction ring (HP:0009775)1.75178150
174Abnormality of placental membranes (HP:0011409)1.75178150
175Cervical subluxation (HP:0003308)1.72249887
176Short palm (HP:0004279)1.70963172
177Plagiocephaly (HP:0001357)1.68947543
178Abnormality of the salivary glands (HP:0010286)1.67710030
179Abnormality of nail color (HP:0100643)1.67123253
180Vertebral arch anomaly (HP:0008438)1.66492449
181Stenosis of the external auditory canal (HP:0000402)1.65994288
182Autoamputation (HP:0001218)1.65176878
183Abnormality of the vertebral endplates (HP:0005106)1.64965127
184Ectopic anus (HP:0004397)1.64938451
185Abdominal distention (HP:0003270)1.63223585
186Abnormality of the lacrimal duct (HP:0011481)1.63195455
187Skin tags (HP:0010609)1.60861251
188Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.60206839
189Spondylolisthesis (HP:0003302)1.57234055
190Genu valgum (HP:0002857)1.54857281
191Premature rupture of membranes (HP:0001788)1.54091305
192Potter facies (HP:0002009)1.53052108
193Facial shape deformation (HP:0011334)1.53052108
194Meningocele (HP:0002435)1.52912749
195Decreased lacrimation (HP:0000633)1.52389491
196Long toe (HP:0010511)1.52178206
197Nasolacrimal duct obstruction (HP:0000579)1.51853385

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK7.58370731
2ADRBK26.03007699
3INSRR5.00582350
4SCYL23.61160477
5NLK3.60716482
6PASK3.00886295
7BRD42.85525250
8LATS12.69578748
9TRPM72.53640627
10TRIB32.46613828
11MAP3K122.30339475
12IRAK42.20142128
13DDR214.3744138
14MAP3K111.91893642
15MAP2K31.87369811
16PKN21.82763348
17MAP3K31.59835558
18DYRK1B1.56457087
19STK391.47536096
20CAMKK11.47133434
21NTRK11.44812758
22RIPK11.40353617
23FRK1.39541291
24TAOK31.38727792
25TAF11.37266740
26MAP3K51.34178752
27WNK31.30830763
28WNK41.30023846
29EPHB11.26390742
30NEK11.18594592
31FGR1.18391121
32UHMK11.18228547
33ERBB31.11701845
34EPHA31.10694137
35CDK61.10125455
36PTK61.08536997
37TESK21.05477325
38SIK11.05227387
39BLK1.00933849
40MARK31.00742082
41MAP3K100.98991748
42PAK40.98475543
43KSR20.97642150
44IKBKE0.96320993
45SGK20.91617964
46CLK10.89675795
47PDGFRA0.89610662
48LRRK20.84211424
49DAPK20.83684934
50YES10.81675949
51MAPKAPK50.80191668
52CSF1R0.78203589
53PAK30.77083438
54FGFR10.72410388
55SYK0.72086121
56ERBB20.71769130
57STK30.71675531
58PAK60.71380663
59BCKDK0.70825244
60NTRK20.70415609
61EPHB20.68265334
62WNK10.68207643
63SGK2230.67767553
64SGK4940.67767553
65CSNK1A1L0.66992899
66MAP3K90.66835674
67LMTK20.64064694
68MAP3K20.62641309
69FGFR30.62108255
70LYN0.60154543
71NEK90.60151060
72LATS20.59995412
73AKT30.59564596
74MET0.57982780
75MELK0.57191231
76MAP3K40.55676257
77PRKD30.54779457
78IRAK10.54668968
79IGF1R0.54256957
80SGK10.53487726
81ILK0.53093686
82MAPKAPK30.52234372
83CSNK1G10.50413344
84KSR10.50223356
85FER0.50187650
86RET0.48810348
87TIE10.48011012
88BMX0.47955696
89TNIK0.46831997
90GRK10.46831424
91CSNK1G20.45936977
92PRKG10.45907441
93DYRK30.45579058
94CDK80.45378509
95SGK30.43501181
96MAP3K130.43380121
97TESK10.43225894
98PAK20.42850593
99HIPK20.41965360
100GRK50.41662751
101FGFR40.41480495
102NTRK30.41357190
103PIM10.40756935
104RIPK40.40611810
105CSNK1G30.40435434
106TGFBR20.39598583
107STK380.39274156
108ADRBK10.39229651
109MAPK150.39154652
110BMPR20.39048570
111ROCK20.37011957
112PTK2B0.36965846
113PLK20.35638663
114ITK0.34922583
115CDK50.34072240
116MATK0.32522743
117PHKG20.32316994
118PHKG10.32316994
119PTK20.31180023
120MYLK0.31126526
121PRKCZ0.30784820
122TEC0.30495661
123PRKCH0.30432300
124BCR0.29892928
125MUSK0.29827274
126ARAF0.29537908
127RPS6KL10.29240061
128RPS6KC10.29240061
129MAPK130.29216881
130CAMKK20.28931700
131NUAK10.28155237
132CDK190.27837175
133GRK60.27823865
134MAP3K70.26832719
135JAK20.26550298
136CAMK40.26152181
137PIM20.25657908
138DAPK30.25151103
139DYRK1A0.24903042
140MAP2K10.24504662
141ZAP700.24074416
142PDGFRB0.22633594
143CSK0.22468846
144ABL10.22190845
145LCK0.21701645
146FLT30.20937334
147MINK10.20217795
148EPHA20.19908226
149PRKCE0.19805439
150PDK10.19603730
151RPS6KA60.19340297
152PRKAA20.19061647
153EEF2K0.18995025
154CAMK1G0.18564706
155FYN0.18412423
156PDPK10.18287455
157GSK3A0.17738682
158MAP2K40.17103947
159PRKCI0.16936929
160TYRO30.15596862
161IRAK20.15370201
162OXSR10.15278298
163SRC0.13824461
164FGFR20.13730401
165CASK0.13695327
166CSNK1D0.12469602
167STK38L0.11888367

Predicted pathways (KEGG)

RankGene SetZ-score
1Other types of O-glycan biosynthesis_Homo sapiens_hsa005144.19384401
2Protein digestion and absorption_Homo sapiens_hsa049743.93377925
3Complement and coagulation cascades_Homo sapiens_hsa046103.52563210
4ECM-receptor interaction_Homo sapiens_hsa045123.39964408
5Basal cell carcinoma_Homo sapiens_hsa052173.32509587
6Hippo signaling pathway_Homo sapiens_hsa043903.24432310
7Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006043.17824238
8Malaria_Homo sapiens_hsa051442.74890256
9Dorso-ventral axis formation_Homo sapiens_hsa043202.52317049
10TGF-beta signaling pathway_Homo sapiens_hsa043502.48292349
11Notch signaling pathway_Homo sapiens_hsa043302.46248090
12Steroid biosynthesis_Homo sapiens_hsa001002.14852486
13Pantothenate and CoA biosynthesis_Homo sapiens_hsa007702.12934440
14Wnt signaling pathway_Homo sapiens_hsa043102.08832713
15Primary immunodeficiency_Homo sapiens_hsa053402.07287749
16Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.02411419
17Steroid hormone biosynthesis_Homo sapiens_hsa001402.02042965
18Proteasome_Homo sapiens_hsa030501.84044778
19Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.83751561
20Focal adhesion_Homo sapiens_hsa045101.83383671
21Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.81648264
22Melanogenesis_Homo sapiens_hsa049161.81154188
23Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.75121118
24ABC transporters_Homo sapiens_hsa020101.73375133
25Cyanoamino acid metabolism_Homo sapiens_hsa004601.68264660
26Proteoglycans in cancer_Homo sapiens_hsa052051.66407641
27Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.65813534
28Fatty acid biosynthesis_Homo sapiens_hsa000611.61284802
29Fatty acid elongation_Homo sapiens_hsa000621.60873907
30Fat digestion and absorption_Homo sapiens_hsa049751.59929375
31Staphylococcus aureus infection_Homo sapiens_hsa051501.55707345
32Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.55280911
33Caffeine metabolism_Homo sapiens_hsa002321.49760600
34RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.42839793
35Chemical carcinogenesis_Homo sapiens_hsa052041.42258740
36Butanoate metabolism_Homo sapiens_hsa006501.40788480
37Lysine degradation_Homo sapiens_hsa003101.38518623
38Retinol metabolism_Homo sapiens_hsa008301.37932757
39Hedgehog signaling pathway_Homo sapiens_hsa043401.36253052
40Chronic myeloid leukemia_Homo sapiens_hsa052201.32826326
41Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.31788852
42Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.31764591
43Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.31113276
44Tight junction_Homo sapiens_hsa045301.28291661
45Histidine metabolism_Homo sapiens_hsa003401.27497703
46Axon guidance_Homo sapiens_hsa043601.25144774
47Phenylalanine metabolism_Homo sapiens_hsa003601.24278703
48Starch and sucrose metabolism_Homo sapiens_hsa005001.23769099
49Peroxisome_Homo sapiens_hsa041461.22248980
50Tyrosine metabolism_Homo sapiens_hsa003501.22057126
51Colorectal cancer_Homo sapiens_hsa052101.22017903
52Renin-angiotensin system_Homo sapiens_hsa046141.21957224
53Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.21564002
54Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.19980291
55Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.19532140
56Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.18359979
57Glycerolipid metabolism_Homo sapiens_hsa005611.18070602
58Bile secretion_Homo sapiens_hsa049761.15922948
59Adherens junction_Homo sapiens_hsa045201.13029247
60Bladder cancer_Homo sapiens_hsa052191.12329196
61Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.09082188
62Olfactory transduction_Homo sapiens_hsa047401.08258715
63Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.07750730
64Leukocyte transendothelial migration_Homo sapiens_hsa046701.07341460
65Nitrogen metabolism_Homo sapiens_hsa009101.04158483
66One carbon pool by folate_Homo sapiens_hsa006701.03891059
67beta-Alanine metabolism_Homo sapiens_hsa004101.03402279
68T cell receptor signaling pathway_Homo sapiens_hsa046601.00461531
69Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.94988378
70Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.94048790
71Renal cell carcinoma_Homo sapiens_hsa052110.93408631
72ErbB signaling pathway_Homo sapiens_hsa040120.93176373
73Estrogen signaling pathway_Homo sapiens_hsa049150.92676134
74Endometrial cancer_Homo sapiens_hsa052130.92514468
75Maturity onset diabetes of the young_Homo sapiens_hsa049500.92282916
76Arginine biosynthesis_Homo sapiens_hsa002200.90839464
77PI3K-Akt signaling pathway_Homo sapiens_hsa041510.89824740
78Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.88615335
79Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.86668371
80Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.86527419
81Amoebiasis_Homo sapiens_hsa051460.85125608
82AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.84497392
83Dilated cardiomyopathy_Homo sapiens_hsa054140.84070904
84Glioma_Homo sapiens_hsa052140.82482495
85Drug metabolism - other enzymes_Homo sapiens_hsa009830.81987230
86Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.81536387
87Pentose and glucuronate interconversions_Homo sapiens_hsa000400.81185734
88Hematopoietic cell lineage_Homo sapiens_hsa046400.80273950
89Melanoma_Homo sapiens_hsa052180.80028624
90N-Glycan biosynthesis_Homo sapiens_hsa005100.79822095
91Long-term depression_Homo sapiens_hsa047300.77295336
92Pathways in cancer_Homo sapiens_hsa052000.74932988
93Fatty acid degradation_Homo sapiens_hsa000710.73650995
94Renin secretion_Homo sapiens_hsa049240.72707928
95Taste transduction_Homo sapiens_hsa047420.71037480
96Phototransduction_Homo sapiens_hsa047440.70659524
97alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.70524099
98Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.69738354
99Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.69366060
100Glycosaminoglycan degradation_Homo sapiens_hsa005310.66875415
101Linoleic acid metabolism_Homo sapiens_hsa005910.66842892
102Prostate cancer_Homo sapiens_hsa052150.65690487
103TNF signaling pathway_Homo sapiens_hsa046680.65188328
104Arachidonic acid metabolism_Homo sapiens_hsa005900.64502666
105Morphine addiction_Homo sapiens_hsa050320.61664244
106GABAergic synapse_Homo sapiens_hsa047270.61432216
107Pancreatic cancer_Homo sapiens_hsa052120.59527922
108Small cell lung cancer_Homo sapiens_hsa052220.58221374
1092-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.57836001
110Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.57630861
111MicroRNAs in cancer_Homo sapiens_hsa052060.57015554
112Fatty acid metabolism_Homo sapiens_hsa012120.56707242
113Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.56169475
114Other glycan degradation_Homo sapiens_hsa005110.55366096
115Vitamin digestion and absorption_Homo sapiens_hsa049770.53991627
116Regulation of autophagy_Homo sapiens_hsa041400.53193744
117Gastric acid secretion_Homo sapiens_hsa049710.52329205
118Tryptophan metabolism_Homo sapiens_hsa003800.51161974
119Regulation of actin cytoskeleton_Homo sapiens_hsa048100.51085661
120Insulin resistance_Homo sapiens_hsa049310.50315157
121Viral myocarditis_Homo sapiens_hsa054160.50296170
122Neurotrophin signaling pathway_Homo sapiens_hsa047220.50063718
123Sulfur metabolism_Homo sapiens_hsa009200.49994134
124Thyroid hormone synthesis_Homo sapiens_hsa049180.49563932
125Rap1 signaling pathway_Homo sapiens_hsa040150.48592566
126Ether lipid metabolism_Homo sapiens_hsa005650.48395148
127Choline metabolism in cancer_Homo sapiens_hsa052310.47922401
128VEGF signaling pathway_Homo sapiens_hsa043700.46566943
129GnRH signaling pathway_Homo sapiens_hsa049120.45714515
130Cocaine addiction_Homo sapiens_hsa050300.45293924
131Prion diseases_Homo sapiens_hsa050200.44341009
132Central carbon metabolism in cancer_Homo sapiens_hsa052300.44132051
133Thyroid cancer_Homo sapiens_hsa052160.43572591
134Ovarian steroidogenesis_Homo sapiens_hsa049130.42898233
135PPAR signaling pathway_Homo sapiens_hsa033200.42390985
136Gap junction_Homo sapiens_hsa045400.42012467
137Nicotine addiction_Homo sapiens_hsa050330.41772550
138Thyroid hormone signaling pathway_Homo sapiens_hsa049190.41653444
139Ras signaling pathway_Homo sapiens_hsa040140.41547778
140Glycerophospholipid metabolism_Homo sapiens_hsa005640.41363365
141Primary bile acid biosynthesis_Homo sapiens_hsa001200.41202925
142Biosynthesis of amino acids_Homo sapiens_hsa012300.40243403
143Glucagon signaling pathway_Homo sapiens_hsa049220.39057667
144Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.38582343
145Toxoplasmosis_Homo sapiens_hsa051450.38508605
146Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.38025715
147Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.37983948
148Hepatitis C_Homo sapiens_hsa051600.37851070
149NF-kappa B signaling pathway_Homo sapiens_hsa040640.36608847
150Adipocytokine signaling pathway_Homo sapiens_hsa049200.36487501
151Vibrio cholerae infection_Homo sapiens_hsa051100.36283217
152Metabolic pathways_Homo sapiens_hsa011000.35876787
153Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.35630395
154Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.35550827
155Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.35255940
156HTLV-I infection_Homo sapiens_hsa051660.35110007
157mTOR signaling pathway_Homo sapiens_hsa041500.34784245
158Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.34119008
159Galactose metabolism_Homo sapiens_hsa000520.33385694
160Dopaminergic synapse_Homo sapiens_hsa047280.32869045
161Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.32279842
162Endocytosis_Homo sapiens_hsa041440.32134830
163Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.31343046
164Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.31312504
165Amphetamine addiction_Homo sapiens_hsa050310.31072816
166Inositol phosphate metabolism_Homo sapiens_hsa005620.31022761
167Insulin signaling pathway_Homo sapiens_hsa049100.30868998
168Pertussis_Homo sapiens_hsa051330.30254394
169Platelet activation_Homo sapiens_hsa046110.29743874
170Calcium signaling pathway_Homo sapiens_hsa040200.29315281
171Measles_Homo sapiens_hsa051620.28058157
172SNARE interactions in vesicular transport_Homo sapiens_hsa041300.22298928
173MAPK signaling pathway_Homo sapiens_hsa040100.21346283
174Protein export_Homo sapiens_hsa030600.21163632

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