TECRL

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene contains a ubiquitin-like domain in the N-terminal region, three transmembrane segments and a C-terminal 3-oxo-5-alpha steroid 4-dehydrogenase domain. The protein belongs to the steroid 5-alpha reductase family. Mutations in this gene result in ventricular tachycardia, catecholaminergic polymorphic, 3. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cardiac myofibril assembly (GO:0055003)9.50679356
2sarcomere organization (GO:0045214)8.66867286
3myofibril assembly (GO:0030239)7.89838426
4cardiac muscle contraction (GO:0060048)7.20432601
5negative regulation of potassium ion transmembrane transporter activity (GO:1901017)7.13557673
6muscle filament sliding (GO:0030049)7.10641060
7actin-myosin filament sliding (GO:0033275)7.10641060
8regulation of relaxation of muscle (GO:1901077)6.88787942
9cardiac muscle cell development (GO:0055013)6.74121486
10regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO6.73209942
11cardiac muscle tissue morphogenesis (GO:0055008)6.62651056
12regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)6.57527774
13tricarboxylic acid cycle (GO:0006099)6.56565047
14cardiac muscle hypertrophy (GO:0003300)6.50267863
15negative regulation of potassium ion transmembrane transport (GO:1901380)6.46980363
16cardiac cell development (GO:0055006)6.35173170
17heart contraction (GO:0060047)6.19109252
18heart process (GO:0003015)6.19109252
19positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)6.17097401
20striated muscle hypertrophy (GO:0014897)6.12783517
21bundle of His cell to Purkinje myocyte communication (GO:0086069)6.12129829
22actin-mediated cell contraction (GO:0070252)6.04746289
23regulation of actin filament-based movement (GO:1903115)5.91826602
24muscle tissue morphogenesis (GO:0060415)5.91594569
25regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)5.91571465
26actomyosin structure organization (GO:0031032)5.91305536
27regulation of sarcomere organization (GO:0060297)5.77073517
28mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.75923107
29ventricular cardiac muscle tissue morphogenesis (GO:0055010)5.72709695
30energy coupled proton transport, down electrochemical gradient (GO:0015985)5.65720666
31ATP synthesis coupled proton transport (GO:0015986)5.65720666
32regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)5.55513400
33ventricular cardiac muscle cell action potential (GO:0086005)5.47089332
34oxidative phosphorylation (GO:0006119)5.45961014
35muscle hypertrophy (GO:0014896)5.44879296
36heart trabecula formation (GO:0060347)5.40052377
37regulation of cell communication by electrical coupling (GO:0010649)5.34089023
38cell communication by electrical coupling involved in cardiac conduction (GO:0086064)5.27926619
39striated muscle contraction (GO:0006941)5.24543583
40regulation of acyl-CoA biosynthetic process (GO:0050812)5.05798838
41adult heart development (GO:0007512)5.04195253
42respiratory electron transport chain (GO:0022904)5.01956857
43regulation of the force of heart contraction (GO:0002026)4.99046287
44electron transport chain (GO:0022900)4.88362329
45mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.85975363
46adrenergic receptor signaling pathway (GO:0071875)4.81351259
47regulation of striated muscle contraction (GO:0006942)4.79361838
48cardiac ventricle formation (GO:0003211)4.78812992
49cell communication involved in cardiac conduction (GO:0086065)4.75514560
50regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)4.74966263
51negative regulation of cardiac muscle cell apoptotic process (GO:0010667)4.73172772
52regulation of skeletal muscle contraction (GO:0014819)4.72260100
53regulation of cofactor metabolic process (GO:0051193)4.70051970
54regulation of coenzyme metabolic process (GO:0051196)4.70051970
55detection of calcium ion (GO:0005513)4.69940966
56membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.58647098
57cell communication by electrical coupling (GO:0010644)4.53634823
58regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)4.52156188
59sarcoplasmic reticulum calcium ion transport (GO:0070296)4.48824003
60regulation of cardioblast differentiation (GO:0051890)4.46954567
61actin filament-based movement (GO:0030048)4.46855808
62response to caffeine (GO:0031000)4.45354338
63carnitine shuttle (GO:0006853)4.42006926
64negative regulation of striated muscle cell apoptotic process (GO:0010664)4.40427431
65relaxation of cardiac muscle (GO:0055119)4.40081727
66regulation of membrane repolarization (GO:0060306)4.26493861
67cardiac muscle adaptation (GO:0014887)4.25256289
68cardiac muscle hypertrophy in response to stress (GO:0014898)4.25256289
69muscle hypertrophy in response to stress (GO:0003299)4.25256289
70cellular response to epinephrine stimulus (GO:0071872)4.23314886
71response to epinephrine (GO:0071871)4.20510521
72regulation of cardiac muscle cell contraction (GO:0086004)4.19851153
73ventricular cardiac muscle cell development (GO:0055015)4.14781603
74relaxation of muscle (GO:0090075)4.09480572
75plasma membrane repair (GO:0001778)4.04533084
76regulation of cardiac muscle contraction (GO:0055117)4.03860287
77positive regulation of cardiac muscle cell differentiation (GO:2000727)4.03560794
78cardiac muscle cell action potential involved in contraction (GO:0086002)4.03397399
79cardiac muscle cell action potential (GO:0086001)4.03114208
80fatty acid transmembrane transport (GO:1902001)3.98610960
81cardiac conduction (GO:0061337)3.98322535
82regulation of heart rate (GO:0002027)3.91817878
83response to stimulus involved in regulation of muscle adaptation (GO:0014874)3.90179096
84regulation of sulfur metabolic process (GO:0042762)3.77870546
85regulation of ATPase activity (GO:0043462)3.76857082
86regulation of ATP catabolic process (GO:1903289)3.76857082
87regulation of heart rate by cardiac conduction (GO:0086091)3.73642611
88ATP biosynthetic process (GO:0006754)3.72974627
89regulation of calcium ion transmembrane transporter activity (GO:1901019)3.67345160
90regulation of calcium ion transmembrane transport (GO:1903169)3.67345160
91positive regulation of heart contraction (GO:0045823)3.66645295
92negative regulation of hormone biosynthetic process (GO:0032353)3.65142376
93striated muscle cell development (GO:0055002)3.62676228
94sequestering of extracellular ligand from receptor (GO:0035581)3.56920661
95regulation of heart contraction (GO:0008016)3.51876815
96atrioventricular valve morphogenesis (GO:0003181)3.51040040
97trabecula formation (GO:0060343)3.48787579
98positive regulation of ATP catabolic process (GO:1903291)3.46457240
99positive regulation of ATPase activity (GO:0032781)3.46457240
100negative regulation of protein localization to cell surface (GO:2000009)3.46082450
101atrial septum morphogenesis (GO:0060413)3.42284660
102regulation of striated muscle cell apoptotic process (GO:0010662)3.39772873
103outflow tract septum morphogenesis (GO:0003148)3.36749340
104regulation of muscle contraction (GO:0006937)3.34603426
105negative regulation of potassium ion transport (GO:0043267)3.33914505
106cardiac muscle tissue development (GO:0048738)3.33556047
107regulation of muscle system process (GO:0090257)3.30986076
108pericardium development (GO:0060039)3.30169979
109desmosome organization (GO:0002934)3.29811093
110positive regulation of cardiac muscle tissue development (GO:0055025)3.29635599
111gap junction assembly (GO:0016264)3.29078143
112succinate metabolic process (GO:0006105)3.27831161
113positive regulation of cardiac muscle tissue growth (GO:0055023)3.27192960
114cardiac chamber formation (GO:0003207)3.24587649
115positive regulation of heart rate (GO:0010460)3.23331824
116positive regulation of cation channel activity (GO:2001259)3.23172594
117negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.21780300
118muscle contraction (GO:0006936)3.20543984
119membrane repolarization during cardiac muscle cell action potential (GO:0086013)3.20013463
120positive regulation of sodium ion transport (GO:0010765)3.19766347
121negative regulation of calcium ion transmembrane transporter activity (GO:1901020)3.18862281
122negative regulation of calcium ion transmembrane transport (GO:1903170)3.18862281
123negative regulation of cytosolic calcium ion concentration (GO:0051481)3.18257644
124positive regulation of calcium ion transmembrane transporter activity (GO:1901021)3.17227184
125regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.17178226
126muscle cell development (GO:0055001)3.15554039

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse7.12414477
2EP300_21415370_ChIP-Seq_HL-1_Mouse6.68317538
3ESRRB_18555785_ChIP-Seq_MESCs_Mouse5.13696520
4RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.99074833
5CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human4.41498242
6TBX20_22328084_ChIP-Seq_HEART_Mouse4.16728727
7TBX20_22080862_ChIP-Seq_HEART_Mouse4.16728727
8MEF2A_21415370_ChIP-Seq_HL-1_Mouse3.91706111
9TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse3.77041948
10GATA4_21415370_ChIP-Seq_HL-1_Mouse3.11756841
11ESR1_20079471_ChIP-ChIP_T-47D_Human2.99140078
12GBX2_23144817_ChIP-Seq_PC3_Human2.90092081
13GATA1_22025678_ChIP-Seq_K562_Human2.72966806
14TRIM28_21343339_ChIP-Seq_HEK293_Human2.72011034
15EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.48859724
16CDX2_19796622_ChIP-Seq_MESCs_Mouse2.38823125
17* ZFP57_27257070_Chip-Seq_ESCs_Mouse2.18063141
18TAF15_26573619_Chip-Seq_HEK293_Human2.14401262
19AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human2.09773861
20PPARD_23208498_ChIP-Seq_MDA-MB-231_Human2.03578396
21NKX2-5_21415370_ChIP-Seq_HL-1_Mouse2.02103140
22BP1_19119308_ChIP-ChIP_Hs578T_Human2.01129831
23ISL1_27105846_Chip-Seq_CPCs_Mouse1.96603719
24* PIAS1_25552417_ChIP-Seq_VCAP_Human1.87667710
25RARG_19884340_ChIP-ChIP_MEFs_Mouse1.85444396
26GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.81480685
27NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.75574695
28PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.72046717
29* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.70111232
30ZNF274_21170338_ChIP-Seq_K562_Hela1.70071596
31ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.67660444
32* P300_19829295_ChIP-Seq_ESCs_Human1.63151629
33PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.61751656
34FUS_26573619_Chip-Seq_HEK293_Human1.60288374
35* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.56625535
36IGF1R_20145208_ChIP-Seq_DFB_Human1.55524995
37TCF4_23295773_ChIP-Seq_U87_Human1.54251870
38STAT3_23295773_ChIP-Seq_U87_Human1.54189882
39HIF1A_21447827_ChIP-Seq_MCF-7_Human1.52643788
40ZNF263_19887448_ChIP-Seq_K562_Human1.52415292
41HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.51743969
42* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.51583708
43SALL4_18804426_ChIP-ChIP_XEN_Mouse1.51095632
44CTBP2_25329375_ChIP-Seq_LNCAP_Human1.50984737
45WT1_19549856_ChIP-ChIP_CCG9911_Human1.50426936
46NR3C1_23031785_ChIP-Seq_PC12_Mouse1.46447586
47CLOCK_20551151_ChIP-Seq_293T_Human1.45782544
48TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.43145538
49EZH2_22144423_ChIP-Seq_EOC_Human1.42179986
50ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.41939201
51EZH2_27294783_Chip-Seq_NPCs_Mouse1.39120408
52ZNF217_24962896_ChIP-Seq_MCF-7_Human1.37161321
53PCGF2_27294783_Chip-Seq_NPCs_Mouse1.36544730
54ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.36205588
55* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.32977568
56BCAT_22108803_ChIP-Seq_LS180_Human1.32958112
57NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.32393730
58SUZ12_27294783_Chip-Seq_NPCs_Mouse1.30095955
59TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.26935076
60FLI1_27457419_Chip-Seq_LIVER_Mouse1.24575969
61RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.22167995
62BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.21538028
63SALL1_21062744_ChIP-ChIP_HESCs_Human1.21134402
64FOXM1_26456572_ChIP-Seq_MCF-7_Human1.20624085
65SMAD_19615063_ChIP-ChIP_OVARY_Human1.19812509
66E2F1_18555785_Chip-Seq_ESCs_Mouse1.18733310
67EWS_26573619_Chip-Seq_HEK293_Human1.17275054
68ER_23166858_ChIP-Seq_MCF-7_Human1.17169785
69SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.16688022
70CJUN_26792858_Chip-Seq_BT549_Human1.15079560
71CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.13857953
72NFE2_27457419_Chip-Seq_LIVER_Mouse1.13593870
73ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.11827916
74SRF_21415370_ChIP-Seq_HL-1_Mouse1.11228230
75PCGF2_27294783_Chip-Seq_ESCs_Mouse1.11097956
76CTBP1_25329375_ChIP-Seq_LNCAP_Human1.10586964
77EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.10427442
78TCF4_22108803_ChIP-Seq_LS180_Human1.10364075
79E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.10303654
80CRX_20693478_ChIP-Seq_RETINA_Mouse1.08338809
81NANOG_18555785_Chip-Seq_ESCs_Mouse1.07616741
82PPAR_26484153_Chip-Seq_NCI-H1993_Human1.07511696
83* AUTS2_25519132_ChIP-Seq_293T-REX_Human1.07239898
84CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.05816446
85CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.04691773
86TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.04641683
87SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.04408106
88MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.03981119
89TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.03501524
90* SOX9_26525672_Chip-Seq_HEART_Mouse1.02671972
91CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.99971919
92* TAL1_26923725_Chip-Seq_HPCs_Mouse0.99230768
93CDX2_22108803_ChIP-Seq_LS180_Human0.98697554
94BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.97463346
95UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.96451730
96SMAD4_21741376_ChIP-Seq_EPCs_Human0.96432033
97KLF5_20875108_ChIP-Seq_MESCs_Mouse0.95363576
98RBPJ_22232070_ChIP-Seq_NCS_Mouse0.95082557
99PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.94949752
100SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.94896882
101SMAD3_21741376_ChIP-Seq_HESCs_Human0.92262844
102GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.91479658
103VDR_22108803_ChIP-Seq_LS180_Human0.90549975
104LXR_22158963_ChIP-Seq_LIVER_Mouse0.90098682
105TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.89890689
106LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.88378566
107FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.86828642
108GATA2_21666600_ChIP-Seq_HMVEC_Human0.86225488
109POU3F2_20337985_ChIP-ChIP_501MEL_Human0.84989165
110THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.83839042
111EZH2_27304074_Chip-Seq_ESCs_Mouse0.83517562
112NR3C1_21868756_ChIP-Seq_MCF10A_Human0.83306207
113SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.83299712
114SOX2_21211035_ChIP-Seq_LN229_Gbm0.83248065
115SMAD4_21799915_ChIP-Seq_A2780_Human0.81080807
116SMAD4_21741376_ChIP-Seq_HESCs_Human0.79617649
117PPARA_22158963_ChIP-Seq_LIVER_Mouse0.79154804
118SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.79070291
119EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.78341661
120GATA1_19941826_ChIP-Seq_K562_Human0.78205636
121EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.77482598
122NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.77466734
123NRF2_20460467_ChIP-Seq_MEFs_Mouse0.77466734
124TP53_16413492_ChIP-PET_HCT116_Human0.76056385
125TBX5_21415370_ChIP-Seq_HL-1_Mouse0.75846593
126WT1_25993318_ChIP-Seq_PODOCYTE_Human0.75340792
127CTNNB1_20460455_ChIP-Seq_HCT116_Human0.73547194
128CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.72864824
129SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.71216393
130RNF2_18974828_ChIP-Seq_MESCs_Mouse0.69733303
131EZH2_18974828_ChIP-Seq_MESCs_Mouse0.69733303
132HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.68889437
133PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.68287401
134CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.66755366
135SMAD3_21741376_ChIP-Seq_EPCs_Human0.66640986
136RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.66450941
137TBL1_22424771_ChIP-Seq_293T_Human0.64458148
138GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.63126758
139GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.62959140
140PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.62931210
141TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.62649343
142CBP_21632823_ChIP-Seq_H3396_Human0.62205417
143TP63_23658742_ChIP-Seq_EP156T_Human0.61371477
144PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.61225624
145MYC_19829295_ChIP-Seq_ESCs_Human0.61214551
146FOXA2_19822575_ChIP-Seq_HepG2_Human0.60336700
147TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.59879207
148AHR_22903824_ChIP-Seq_MCF-7_Human0.58895201
149TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.58677686

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004084_abnormal_cardiac_muscle6.45478036
2MP0002837_dystrophic_cardiac_calcinosis5.15451906
3MP0003646_muscle_fatigue4.85869750
4MP0004215_abnormal_myocardial_fiber4.70891277
5MP0000749_muscle_degeneration4.40960826
6MP0004036_abnormal_muscle_relaxation4.35811800
7MP0000751_myopathy4.20695000
8MP0005330_cardiomyopathy4.13577048
9MP0002972_abnormal_cardiac_muscle3.54779268
10MP0008775_abnormal_heart_ventricle3.44805871
11MP0004484_altered_response_of3.09095330
12MP0004087_abnormal_muscle_fiber3.07899855
13MP0003137_abnormal_impulse_conducting3.05105759
14MP0001544_abnormal_cardiovascular_syste2.89945687
15MP0005385_cardiovascular_system_phenoty2.89945687
16MP0010630_abnormal_cardiac_muscle2.87694009
17MP0005620_abnormal_muscle_contractility2.82860274
18MP0006138_congestive_heart_failure2.78728610
19MP0003221_abnormal_cardiomyocyte_apopto2.74786415
20MP0004510_myositis2.59811151
21MP0004085_abnormal_heartbeat2.46297713
22MP0002106_abnormal_muscle_physiology2.43381020
23MP0004145_abnormal_muscle_electrophysio2.38532023
24MP0003828_pulmonary_edema2.37858453
25MP0004130_abnormal_muscle_cell2.20210143
26MP0002127_abnormal_cardiovascular_syste2.16763982
27MP0000750_abnormal_muscle_regeneration2.15266401
28MP0002269_muscular_atrophy2.10452147
29MP0006036_abnormal_mitochondrial_physio1.98630384
30MP0003567_abnormal_fetal_cardiomyocyte1.96192017
31MP0005369_muscle_phenotype1.93430255
32MP0004233_abnormal_muscle_weight1.80731171
33MP0000747_muscle_weakness1.75351775
34MP0002102_abnormal_ear_morphology1.66347212
35MP0000759_abnormal_skeletal_muscle1.65293907
36MP0003950_abnormal_plasma_membrane1.65101229
37MP0005451_abnormal_body_composition1.44641342
38MP0002332_abnormal_exercise_endurance1.37598992
39MP0000266_abnormal_heart_morphology1.32331281
40MP0001661_extended_life_span1.29961839
41MP0010368_abnormal_lymphatic_system1.23227474
42MP0005165_increased_susceptibility_to1.20828882
43MP0006035_abnormal_mitochondrial_morpho1.15921579
44MP0003122_maternal_imprinting1.14315925
45MP0000343_altered_response_to1.10467283
46MP0009384_cardiac_valve_regurgitation1.07093848
47MP0000230_abnormal_systemic_arterial1.01817862
48MP0004272_abnormal_basement_membrane0.96837891
49MP0003045_fibrosis0.94715424
50MP0002128_abnormal_blood_circulation0.88481363
51MP0005666_abnormal_adipose_tissue0.87154318
52MP0003279_aneurysm0.86063806
53MP0003566_abnormal_cell_adhesion0.85707827
54MP0005248_abnormal_Harderian_gland0.81229058
55MP0001879_abnormal_lymphatic_vessel0.78367283
56MP0000462_abnormal_digestive_system0.78315340
57MP0005266_abnormal_metabolism0.74097562
58MP0003941_abnormal_skin_development0.70289276
59MP0005670_abnormal_white_adipose0.69902242
60MP0003937_abnormal_limbs/digits/tail_de0.69837423
61MP0001984_abnormal_olfaction0.68734883
62MP0002234_abnormal_pharynx_morphology0.68499406
63MP0000767_abnormal_smooth_muscle0.66781721
64MP0003984_embryonic_growth_retardation0.64667676
65MP0002088_abnormal_embryonic_growth/wei0.64496869
66MP0002925_abnormal_cardiovascular_devel0.62924669
67MP0003806_abnormal_nucleotide_metabolis0.62388573
68MP0004043_abnormal_pH_regulation0.58560055
69MP0009250_abnormal_appendicular_skeleto0.57014990
70MP0002108_abnormal_muscle_morphology0.56753973
71MP0005623_abnormal_meninges_morphology0.56523756
72MP0002638_abnormal_pupillary_reflex0.51731209
73MP0001784_abnormal_fluid_regulation0.50542973
74MP0003136_yellow_coat_color0.48300575
75MP0008004_abnormal_stomach_pH0.47949417
76MP0001614_abnormal_blood_vessel0.46664112
77MP0005375_adipose_tissue_phenotype0.46257156
78MP0005253_abnormal_eye_physiology0.45959365
79MP0005187_abnormal_penis_morphology0.44179256
80MP0002168_other_aberrant_phenotype0.44152834
81MP0004147_increased_porphyrin_level0.44140129
82MP0003121_genomic_imprinting0.43190477
83MP0002909_abnormal_adrenal_gland0.42933785
84MP0006072_abnormal_retinal_apoptosis0.40972868
85MP0000733_abnormal_muscle_development0.40963014
86MP0005595_abnormal_vascular_smooth0.40455402
87MP0005380_embryogenesis_phenotype0.40284311
88MP0001672_abnormal_embryogenesis/_devel0.40284311
89MP0005503_abnormal_tendon_morphology0.39057005
90MP0003123_paternal_imprinting0.38919678
91MP0003948_abnormal_gas_homeostasis0.37967986
92MP0002009_preneoplasia0.35579806
93MP0005085_abnormal_gallbladder_physiolo0.35225674
94MP0004185_abnormal_adipocyte_glucose0.34862084
95MP0005388_respiratory_system_phenotype0.34314107
96MP0002133_abnormal_respiratory_system0.34314107
97MP0001529_abnormal_vocalization0.33435157
98MP0005319_abnormal_enzyme/_coenzyme0.33389732
99MP0001727_abnormal_embryo_implantation0.31771515
100MP0000013_abnormal_adipose_tissue0.31093546
101MP0003935_abnormal_craniofacial_develop0.30804010
102MP0002971_abnormal_brown_adipose0.30500405
103MP0000534_abnormal_ureter_morphology0.29475173
104MP0002078_abnormal_glucose_homeostasis0.29321471
105MP0005535_abnormal_body_temperature0.28597658
106MP0005551_abnormal_eye_electrophysiolog0.26900844
107MP0002295_abnormal_pulmonary_circulatio0.26888048
108MP0005171_absent_coat_pigmentation0.26795767
109MP0003705_abnormal_hypodermis_morpholog0.26400967
110MP0003385_abnormal_body_wall0.25971066
111MP0003115_abnormal_respiratory_system0.25842855
112MP0004924_abnormal_behavior0.25687050
113MP0005386_behavior/neurological_phenoty0.25687050
114MP0000372_irregular_coat_pigmentation0.25468501
115MP0000537_abnormal_urethra_morphology0.24392310
116MP0001175_abnormal_lung_morphology0.22512740
117MP0005332_abnormal_amino_acid0.22498088
118MP0001299_abnormal_eye_distance/0.22372523
119MP0009697_abnormal_copulation0.21992329
120MP0001486_abnormal_startle_reflex0.21792287
121MP0000762_abnormal_tongue_morphology0.21698866
122MP0005377_hearing/vestibular/ear_phenot0.21016339
123MP0003878_abnormal_ear_physiology0.21016339
124MP0001697_abnormal_embryo_size0.20825960
125MP0002090_abnormal_vision0.20458708
126MP0009745_abnormal_behavioral_response0.18883930
127MP0002822_catalepsy0.18225443
128MP0000427_abnormal_hair_cycle0.18098451
129MP0008569_lethality_at_weaning0.17310421

Predicted human phenotypes

RankGene SetZ-score
1Sudden death (HP:0001699)7.80346030
2Ventricular tachycardia (HP:0004756)7.16618172
3Atrial fibrillation (HP:0005110)6.82987533
4Exercise-induced muscle cramps (HP:0003710)6.41970599
5Primary atrial arrhythmia (HP:0001692)6.37757898
6Supraventricular tachycardia (HP:0004755)6.16545755
7Supraventricular arrhythmia (HP:0005115)6.01505403
8Calf muscle hypertrophy (HP:0008981)5.93822961
9Lipoatrophy (HP:0100578)5.75438856
10Syncope (HP:0001279)5.41618091
11Right ventricular cardiomyopathy (HP:0011663)5.41190421
12Muscle hypertrophy of the lower extremities (HP:0008968)5.30533693
13Myoglobinuria (HP:0002913)5.16355073
14Exercise-induced myalgia (HP:0003738)5.00025737
15Abnormality of the calf musculature (HP:0001430)4.87163023
16Palpitations (HP:0001962)4.73634394
17Dilated cardiomyopathy (HP:0001644)4.58262948
18Ventricular arrhythmia (HP:0004308)4.45170379
19Bundle branch block (HP:0011710)4.37371068
20Hyporeflexia of lower limbs (HP:0002600)4.32574142
21Prolonged QT interval (HP:0001657)4.21225796
22Abnormality of the left ventricular outflow tract (HP:0011103)4.18904060
23Subaortic stenosis (HP:0001682)4.18904060
24Muscle fiber splitting (HP:0003555)4.16857020
25Rhabdomyolysis (HP:0003201)4.07558433
26Heart block (HP:0012722)3.79740089
27EMG: myopathic abnormalities (HP:0003458)3.75568656
28Acute necrotizing encephalopathy (HP:0006965)3.74518169
29Abnormal mitochondria in muscle tissue (HP:0008316)3.73305285
30Abnormal atrioventricular conduction (HP:0005150)3.54773439
31Ventricular fibrillation (HP:0001663)3.47868843
32Atrioventricular block (HP:0001678)3.40652776
33Hepatic necrosis (HP:0002605)3.35817706
34EMG: neuropathic changes (HP:0003445)3.32653001
35Left ventricular hypertrophy (HP:0001712)3.27346202
36Increased serum pyruvate (HP:0003542)3.25336471
37Abnormality of glycolysis (HP:0004366)3.25336471
38Asymmetric septal hypertrophy (HP:0001670)3.20809279
39Hypoglycemic coma (HP:0001325)3.16717274
40Acute encephalopathy (HP:0006846)3.16406334
41Progressive macrocephaly (HP:0004481)3.12147519
42Abnormal EKG (HP:0003115)3.08574696
43Type 1 muscle fiber predominance (HP:0003803)2.99800788
44Mitochondrial inheritance (HP:0001427)2.91440701
45Palmoplantar keratoderma (HP:0000982)2.89525136
46Increased CSF lactate (HP:0002490)2.88296649
47Ragged-red muscle fibers (HP:0003200)2.87256466
48Cerebral edema (HP:0002181)2.81767032
49Conjunctival hamartoma (HP:0100780)2.79651682
50Hepatocellular necrosis (HP:0001404)2.76737072
51Hip contracture (HP:0003273)2.74157000
52Exercise intolerance (HP:0003546)2.72141317
53Distal lower limb muscle weakness (HP:0009053)2.71452726
54Increased connective tissue (HP:0009025)2.70420244
55Pheochromocytoma (HP:0002666)2.67023786
56Abnormality of alanine metabolism (HP:0010916)2.64091278
57Hyperalaninemia (HP:0003348)2.64091278
58Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.64091278
59Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.60790886
60Ketoacidosis (HP:0001993)2.54896908
61Muscle fiber inclusion bodies (HP:0100299)2.51461702
62Steppage gait (HP:0003376)2.47611141
63Dicarboxylic aciduria (HP:0003215)2.47421195
64Abnormality of dicarboxylic acid metabolism (HP:0010995)2.47421195
65Congenital malformation of the right heart (HP:0011723)2.45534075
66Double outlet right ventricle (HP:0001719)2.45534075
67Abnormality of fatty-acid metabolism (HP:0004359)2.43540116
68Neoplasm of the adrenal gland (HP:0100631)2.41196195
69Neuroendocrine neoplasm (HP:0100634)2.40678015
70Lactic acidosis (HP:0003128)2.40375255
71Nemaline bodies (HP:0003798)2.37029633
72Muscular dystrophy (HP:0003560)2.37019615
73Respiratory failure (HP:0002878)2.33151345
74Increased muscle lipid content (HP:0009058)2.29622809
75Hypoplastic left heart (HP:0004383)2.29349613
76Myotonia (HP:0002486)2.28985404
77Generalized aminoaciduria (HP:0002909)2.25961645
78Difficulty running (HP:0009046)2.25051268
79Patent foramen ovale (HP:0001655)2.23202219
80Diaphragmatic weakness (HP:0009113)2.18970198
81Esophageal neoplasm (HP:0100751)2.17826898
82Neoplasm of head and neck (HP:0012288)2.17826898
83Areflexia of lower limbs (HP:0002522)2.15578333
84Neck muscle weakness (HP:0000467)2.13297123
85Sudden cardiac death (HP:0001645)2.12687502
86Increased intramyocellular lipid droplets (HP:0012240)2.11867060
87Limited hip movement (HP:0008800)2.11431107
88Rimmed vacuoles (HP:0003805)2.10742837
89Bicuspid aortic valve (HP:0001647)2.07898183
90Lipid accumulation in hepatocytes (HP:0006561)2.06059568
91Congestive heart failure (HP:0001635)2.03557426
92Nausea (HP:0002018)2.00234610
93Bradycardia (HP:0001662)1.99665975
94Generalized muscle weakness (HP:0003324)1.98429969
95Pancreatic islet-cell hyperplasia (HP:0004510)1.93844553
96Muscle stiffness (HP:0003552)1.91479236
97Hyperglycemia (HP:0003074)1.88274701
98Hamartoma of the eye (HP:0010568)1.87586365
99Abnormality of the foot musculature (HP:0001436)1.85299204
100Hypoplastic heart (HP:0001961)1.80108464
101Dysmetric saccades (HP:0000641)1.79139790
102Centrally nucleated skeletal muscle fibers (HP:0003687)1.78556565
103Increased serum lactate (HP:0002151)1.78471430
104Tinnitus (HP:0000360)1.77246352
105Increased hepatocellular lipid droplets (HP:0006565)1.75664985
106Renal cortical cysts (HP:0000803)1.75059889
107Decreased activity of mitochondrial respiratory chain (HP:0008972)1.74827551
108Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.74827551
109Foot dorsiflexor weakness (HP:0009027)1.73226642
110Ketosis (HP:0001946)1.72911051
111Childhood onset (HP:0011463)1.72616959
112Gowers sign (HP:0003391)1.71067437
113Toxemia of pregnancy (HP:0100603)1.69384925
114Proximal tubulopathy (HP:0000114)1.68425901
115Mildly elevated creatine phosphokinase (HP:0008180)1.65892144
116Increased variability in muscle fiber diameter (HP:0003557)1.58744666
117Skin pits (HP:0100276)1.57766138
118Periauricular skin pits (HP:0100277)1.55536552
119Preauricular pit (HP:0004467)1.55536552
120Frequent falls (HP:0002359)1.53241175
121Central scotoma (HP:0000603)1.49480312
122Abnormality of the endocardium (HP:0004306)1.48984318
123Abnormality of the tricuspid valve (HP:0001702)1.46534055
124Scapular winging (HP:0003691)1.45569459
125Abnormality of the ischium (HP:0003174)1.43286491
126Vitreoretinal degeneration (HP:0000655)1.42847913
127Abnormality of skeletal muscle fiber size (HP:0012084)1.42783199
128Knee flexion contracture (HP:0006380)1.37581614
129Proximal amyotrophy (HP:0007126)1.35693910
130Aplasia of the musculature (HP:0100854)1.34099433
131Abnormality of the shoulder girdle musculature (HP:0001435)1.31746158
132Acanthocytosis (HP:0001927)1.28329771
133Papillary thyroid carcinoma (HP:0002895)1.28314910
134Late onset (HP:0003584)1.27355007
135Progressive muscle weakness (HP:0003323)1.27129272
136Pulmonary artery stenosis (HP:0004415)1.26650501
137Abnormal ventriculo-arterial connection (HP:0011563)1.25967643
138Transposition of the great arteries (HP:0001669)1.25967643
139Abnormal connection of the cardiac segments (HP:0011545)1.25967643
140Aneurysm (HP:0002617)1.25276352
141Skin nodule (HP:0200036)1.24625086

Predicted kinase interactions (KEA)

RankGene SetZ-score
1OBSCN6.83222604
2MYLK4.80255162
3TTN4.19275702
4STK243.45432658
5PDK43.25141746
6PDK33.25141746
7DMPK3.20147502
8PKN23.14799810
9LMTK23.03670917
10PIK3CA2.78747296
11PHKG12.65289907
12PHKG22.65289907
13TIE12.30127269
14ZAK2.28364551
15FRK2.24152717
16BCKDK1.99695925
17STK38L1.96468722
18GRK71.91327611
19PDK21.87508508
20NEK11.76587965
21MUSK1.69433449
22ILK1.48606795
23PINK11.47556368
24LIMK11.42764679
25CAMK2D1.34066447
26CDC42BPA1.30973124
27PAK31.29442555
28WNK41.25865569
29STK41.21630311
30TRIB31.20973138
31FLT31.20458035
32TRPM71.16303396
33INSRR1.12073776
34PTK2B1.11584120
35MARK11.06794037
36ROCK11.05299084
37PRPF4B1.03070003
38PRKD10.98816768
39AKT30.95947118
40NEK90.92715877
41PRKAA20.90211469
42CAMK10.89420986
43MAP3K70.87341520
44STK390.85648648
45CAMK40.84609343
46WNK10.81715307
47DAPK30.79642629
48TNIK0.76499032
49ACVR1B0.74787355
50MAPK70.69221661
51CAMK2A0.68792150
52NME20.68199289
53PRKAA10.68100974
54MAP3K60.64716217
55MAPK120.64259963
56ERBB30.60982400
57RET0.59409808
58EPHA30.59113813
59BMPR1B0.58970358
60PKN10.58790029
61ROCK20.58108397
62AKT20.57506360
63EPHA40.56054619
64MAP3K50.56031521
65KDR0.53943807
66NLK0.53200168
67PDGFRA0.51162817
68RPS6KC10.49584612
69RPS6KL10.49584612
70EPHB20.46099733
71CASK0.46029373
72MAP2K30.45702720
73PRKACA0.44415633
74STK380.43836398
75CAMK2G0.42881058
76TESK10.42146466
77PRKACB0.41850818
78WNK30.41461265
79FGFR10.38078328
80TAOK20.37985853
81RPS6KA60.37878057
82RIPK10.37256706
83LRRK20.36700818
84PRKCE0.35268778
85ITK0.35230607
86PRKD30.35049943
87MAP3K40.34987681
88CAMK2B0.34423262
89BRSK20.34411161
90PRKACG0.34053488
91MAP3K30.33816581
92STK30.33308593
93NUAK10.33055340
94SGK20.32141114
95MAP2K10.30606307
96PRKCQ0.30270909
97PRKG10.28389370
98MAPK130.27776987
99MAPK40.27413306
100TGFBR20.25679258
101STK110.25073040
102PRKG20.23628945
103PAK20.23246287
104MAP4K20.23138780
105RPS6KA10.21549413
106LATS10.21435941
107MKNK20.20723284
108MARK30.20178583
109MAP2K40.19158944
110PLK20.18811394
111UHMK10.18312525
112MAPK100.17785676
113LATS20.17576206
114CCNB10.17381356
115MAPKAPK30.17139640
116ADRBK10.16728863
117FGFR30.14942330
118SGK10.13794693
119PLK40.13613107
120BCR0.12540358
121PDK10.12278314
122EGFR0.10729414
123RAF10.09824712
124PTK60.09218908
125PIK3CG0.08917305
126RPS6KA30.08483317
127AKT10.06835650
128PRKCH0.06779326
129FER0.06734865
130MAP3K100.05574651

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000205.96980428
2Cardiac muscle contraction_Homo sapiens_hsa042604.86155454
3Parkinsons disease_Homo sapiens_hsa050123.99107283
4Oxidative phosphorylation_Homo sapiens_hsa001903.89146190
52-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.83394112
6Dilated cardiomyopathy_Homo sapiens_hsa054143.62252576
7Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054103.61111043
8Propanoate metabolism_Homo sapiens_hsa006403.35502921
9Alzheimers disease_Homo sapiens_hsa050102.86646919
10Huntingtons disease_Homo sapiens_hsa050162.69583706
11Fatty acid degradation_Homo sapiens_hsa000712.63286986
12Carbon metabolism_Homo sapiens_hsa012002.62923434
13Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.47128858
14Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.44616282
15Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.41765346
16Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.36907091
17Fatty acid metabolism_Homo sapiens_hsa012122.05947536
18Pyruvate metabolism_Homo sapiens_hsa006201.83247940
19Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.73369473
20Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.72706318
21Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.57280090
22Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.55500144
23Fatty acid elongation_Homo sapiens_hsa000621.54806946
24Biosynthesis of amino acids_Homo sapiens_hsa012301.27632408
25Viral myocarditis_Homo sapiens_hsa054161.24144554
26Butanoate metabolism_Homo sapiens_hsa006501.22614236
27Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.19465120
28Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.14537991
29cGMP-PKG signaling pathway_Homo sapiens_hsa040221.05748405
30HIF-1 signaling pathway_Homo sapiens_hsa040661.02047610
31Glucagon signaling pathway_Homo sapiens_hsa049220.96210639
32Starch and sucrose metabolism_Homo sapiens_hsa005000.90244752
33Pancreatic secretion_Homo sapiens_hsa049720.88086270
34Insulin resistance_Homo sapiens_hsa049310.80810371
35Taste transduction_Homo sapiens_hsa047420.78351203
36PPAR signaling pathway_Homo sapiens_hsa033200.76072148
37Central carbon metabolism in cancer_Homo sapiens_hsa052300.70716013
38Galactose metabolism_Homo sapiens_hsa000520.70425648
39Calcium signaling pathway_Homo sapiens_hsa040200.70245046
40Insulin signaling pathway_Homo sapiens_hsa049100.70044450
41Morphine addiction_Homo sapiens_hsa050320.66424420
42Adipocytokine signaling pathway_Homo sapiens_hsa049200.64262968
43Tryptophan metabolism_Homo sapiens_hsa003800.64119398
44Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.63540120
45beta-Alanine metabolism_Homo sapiens_hsa004100.62844926
46Salivary secretion_Homo sapiens_hsa049700.61876412
47Focal adhesion_Homo sapiens_hsa045100.61787038
48Vascular smooth muscle contraction_Homo sapiens_hsa042700.61323884
49Oxytocin signaling pathway_Homo sapiens_hsa049210.59987972
50Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.58887379
51Tight junction_Homo sapiens_hsa045300.58710353
52Tyrosine metabolism_Homo sapiens_hsa003500.58574816
53Mineral absorption_Homo sapiens_hsa049780.56640532
54Phenylalanine metabolism_Homo sapiens_hsa003600.56161494
55Lysine degradation_Homo sapiens_hsa003100.53732517
56Adherens junction_Homo sapiens_hsa045200.53122162
57GABAergic synapse_Homo sapiens_hsa047270.52944682
58Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.49044753
59Linoleic acid metabolism_Homo sapiens_hsa005910.48010545
60Peroxisome_Homo sapiens_hsa041460.46418254
61Bile secretion_Homo sapiens_hsa049760.45340137
62Fructose and mannose metabolism_Homo sapiens_hsa000510.44219757
63Glycerophospholipid metabolism_Homo sapiens_hsa005640.42468182
64Regulation of autophagy_Homo sapiens_hsa041400.41706706
65AMPK signaling pathway_Homo sapiens_hsa041520.41374557
66Arginine and proline metabolism_Homo sapiens_hsa003300.40846138
67Type II diabetes mellitus_Homo sapiens_hsa049300.40291743
68Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.39080067
69Metabolic pathways_Homo sapiens_hsa011000.38555301
70Amphetamine addiction_Homo sapiens_hsa050310.36735941
71cAMP signaling pathway_Homo sapiens_hsa040240.35810015
72Primary bile acid biosynthesis_Homo sapiens_hsa001200.35720837
73Dorso-ventral axis formation_Homo sapiens_hsa043200.34735248
74Melanoma_Homo sapiens_hsa052180.32652782
75Arginine biosynthesis_Homo sapiens_hsa002200.32224211
76Serotonergic synapse_Homo sapiens_hsa047260.31766594
77Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.30956138
78ABC transporters_Homo sapiens_hsa020100.30925977
79Glutamatergic synapse_Homo sapiens_hsa047240.30036538
80Renin secretion_Homo sapiens_hsa049240.27612711
81Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.27338911
82Leukocyte transendothelial migration_Homo sapiens_hsa046700.27257275
83Protein digestion and absorption_Homo sapiens_hsa049740.26952558
84Thyroid hormone signaling pathway_Homo sapiens_hsa049190.25969128
85Hedgehog signaling pathway_Homo sapiens_hsa043400.25918282
86Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.25048975
87Thyroid hormone synthesis_Homo sapiens_hsa049180.24978051
88ECM-receptor interaction_Homo sapiens_hsa045120.24833724
89Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.24709173
90alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.24497983
91Regulation of actin cytoskeleton_Homo sapiens_hsa048100.23207192
92Longevity regulating pathway - mammal_Homo sapiens_hsa042110.22638819
93Proteoglycans in cancer_Homo sapiens_hsa052050.22496306
94Circadian entrainment_Homo sapiens_hsa047130.22421316
95Cysteine and methionine metabolism_Homo sapiens_hsa002700.21528081
96Phospholipase D signaling pathway_Homo sapiens_hsa040720.21443416
97Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.21294329
98Insulin secretion_Homo sapiens_hsa049110.18521612
99Sulfur metabolism_Homo sapiens_hsa009200.17058967
100Gastric acid secretion_Homo sapiens_hsa049710.12574031
101Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.10463600
102Fatty acid biosynthesis_Homo sapiens_hsa000610.10377487
103Hippo signaling pathway_Homo sapiens_hsa043900.07524877
104Amoebiasis_Homo sapiens_hsa051460.04496111
105Circadian rhythm_Homo sapiens_hsa047100.04287747
106Renal cell carcinoma_Homo sapiens_hsa052110.03105550
107Pentose phosphate pathway_Homo sapiens_hsa000300.02002447
108FoxO signaling pathway_Homo sapiens_hsa040680.01365248
109Cholinergic synapse_Homo sapiens_hsa047250.01092729
110Purine metabolism_Homo sapiens_hsa00230-0.0851145
111Endometrial cancer_Homo sapiens_hsa05213-0.0801558
112Rap1 signaling pathway_Homo sapiens_hsa04015-0.0744571
113RNA degradation_Homo sapiens_hsa03018-0.0660029
114Gap junction_Homo sapiens_hsa04540-0.0534466
115PI3K-Akt signaling pathway_Homo sapiens_hsa04151-0.0515786
116Pathways in cancer_Homo sapiens_hsa05200-0.0458765
117Glycerolipid metabolism_Homo sapiens_hsa00561-0.0458253
118Basal cell carcinoma_Homo sapiens_hsa05217-0.0391982
119Olfactory transduction_Homo sapiens_hsa04740-0.0314576
120Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0234369
121Fat digestion and absorption_Homo sapiens_hsa04975-0.0207275
122Small cell lung cancer_Homo sapiens_hsa05222-0.0202411
123Melanogenesis_Homo sapiens_hsa04916-0.0181183
124Glycine, serine and threonine metabolism_Homo sapiens_hsa00260-0.0180748
125TGF-beta signaling pathway_Homo sapiens_hsa04350-0.0073553
126Platelet activation_Homo sapiens_hsa04611-0.0056023
127Aldosterone synthesis and secretion_Homo sapiens_hsa04925-0.0004996

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