TDRP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1interferon-gamma secretion (GO:0072643)8.84138915
2labyrinthine layer development (GO:0060711)6.14601496
3folic acid metabolic process (GO:0046655)6.14423571
4regulation of histone H3-K27 methylation (GO:0061085)5.92746194
5folic acid transport (GO:0015884)5.87590111
6regulation of gene silencing by RNA (GO:0060966)5.68595593
7regulation of posttranscriptional gene silencing (GO:0060147)5.68595593
8regulation of gene silencing by miRNA (GO:0060964)5.68595593
9intestinal epithelial cell development (GO:0060576)5.24775450
10proteasome assembly (GO:0043248)4.96950527
11modified amino acid transport (GO:0072337)4.53712780
12paraxial mesoderm development (GO:0048339)4.46478328
13CDP-diacylglycerol metabolic process (GO:0046341)4.46116171
14piRNA metabolic process (GO:0034587)4.25388349
15fructose metabolic process (GO:0006000)4.19122431
16presynaptic membrane assembly (GO:0097105)4.09193283
17anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:04.08496701
18formation of translation preinitiation complex (GO:0001731)4.05819426
19positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)4.05802896
20purine nucleobase biosynthetic process (GO:0009113)4.01202313
21regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)4.00474649
22negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.99657501
23mitotic metaphase plate congression (GO:0007080)3.95004935
24ribosome assembly (GO:0042255)3.85155268
25regulation of cellular amino acid metabolic process (GO:0006521)3.84773513
26positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.73615967
27regulation of translation in response to stress (GO:0043555)3.67016309
28regulation of cardioblast differentiation (GO:0051890)3.65005900
29negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.58572469
30negative regulation of ligase activity (GO:0051352)3.58572469
31positive regulation of SMAD protein import into nucleus (GO:0060391)3.53364606
32nucleobase biosynthetic process (GO:0046112)3.52417101
33regulation of histone H3-K9 methylation (GO:0051570)3.51589285
34synaptonemal complex assembly (GO:0007130)3.51141707
35regulation of non-canonical Wnt signaling pathway (GO:2000050)3.47994406
36presynaptic membrane organization (GO:0097090)3.46977811
37pre-miRNA processing (GO:0031054)3.45752616
38alditol metabolic process (GO:0019400)3.44477126
39positive regulation of ligase activity (GO:0051351)3.43806159
40rRNA modification (GO:0000154)3.41849006
41CDP-diacylglycerol biosynthetic process (GO:0016024)3.41246169
42regulation of cell-cell adhesion mediated by cadherin (GO:2000047)3.38116104
43protein insertion into membrane (GO:0051205)3.37857216
44signal transduction involved in DNA integrity checkpoint (GO:0072401)3.34569152
45signal transduction involved in DNA damage checkpoint (GO:0072422)3.34569152
46protein complex localization (GO:0031503)3.34172804
47regulation of cell fate specification (GO:0042659)3.33840461
48blastocyst development (GO:0001824)3.33438164
49cullin deneddylation (GO:0010388)3.32864778
50heme transport (GO:0015886)3.32603925
51signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.32214144
52signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.32214144
53signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.32214144
54lateral sprouting from an epithelium (GO:0060601)3.32183246
55DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.31535907
56positive regulation of catenin import into nucleus (GO:0035413)3.30358206
57signal transduction involved in cell cycle checkpoint (GO:0072395)3.27822353
58regulation of ubiquitin-protein transferase activity (GO:0051438)3.27612652
59synaptonemal complex organization (GO:0070193)3.25447264
60establishment of protein localization to mitochondrial membrane (GO:0090151)3.25186825
61intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.25136836
62signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.25136836
63negative regulation of gene silencing (GO:0060969)3.24709504
64protein deneddylation (GO:0000338)3.24365134
65regulation of Wnt signaling pathway involved in heart development (GO:0003307)3.22456423
66keratinocyte development (GO:0003334)3.22361700
67regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)3.21782825
68lung-associated mesenchyme development (GO:0060484)3.20662626
69meiosis I (GO:0007127)3.14789999
70trophectodermal cell differentiation (GO:0001829)3.13321921
71notochord development (GO:0030903)3.06745790
72dorsal/ventral axis specification (GO:0009950)3.06421432
73regulation of translational termination (GO:0006449)3.05563481
74regulation of ligase activity (GO:0051340)3.04472405
75L-methionine salvage (GO:0071267)3.00334417
76L-methionine biosynthetic process (GO:0071265)3.00334417
77amino acid salvage (GO:0043102)3.00334417
78kidney morphogenesis (GO:0060993)3.00156978
79DNA replication checkpoint (GO:0000076)2.98816061
80negative regulation of translational initiation (GO:0045947)2.98814239
81metaphase plate congression (GO:0051310)2.95766174
82male meiosis I (GO:0007141)2.93784322
83vitamin transport (GO:0051180)2.91711616
84anterior/posterior axis specification, embryo (GO:0008595)2.91687917
85DNA methylation involved in gamete generation (GO:0043046)2.90041744
86regulation of gene silencing (GO:0060968)2.87244632
87ribosome biogenesis (GO:0042254)2.85305899
88transcytosis (GO:0045056)2.84798832
89pantothenate metabolic process (GO:0015939)2.84713474
90amino sugar catabolic process (GO:0046348)2.84346785
91sulfur amino acid biosynthetic process (GO:0000097)2.82590032
92autophagic vacuole assembly (GO:0000045)2.77184694
93regulation of SMAD protein import into nucleus (GO:0060390)2.76884794
94regulation of mitochondrial translation (GO:0070129)2.76531390
95methionine biosynthetic process (GO:0009086)2.75959476
96single strand break repair (GO:0000012)2.75417067
97positive regulation of cell cycle arrest (GO:0071158)2.75212501
98regulation of cellular amine metabolic process (GO:0033238)2.75134044
99L-serine metabolic process (GO:0006563)2.75091834
100biotin metabolic process (GO:0006768)2.74814432
101meiotic nuclear division (GO:0007126)2.74540738
102acrosome assembly (GO:0001675)2.73986365
103convergent extension (GO:0060026)2.73255947
104regulation of double-strand break repair via homologous recombination (GO:0010569)2.73218952
105chaperone-mediated protein complex assembly (GO:0051131)2.71790391
106cell fate commitment involved in formation of primary germ layer (GO:0060795)2.71133559
107cofactor transport (GO:0051181)2.70598153
108embryonic body morphogenesis (GO:0010172)2.69607365
109nodal signaling pathway (GO:0038092)2.68870467
110establishment of chromosome localization (GO:0051303)2.68224358
111negative regulation of histone methylation (GO:0031061)2.67770333
112male meiosis (GO:0007140)2.67302308
113cell migration involved in gastrulation (GO:0042074)2.67068102
114regulation of spindle organization (GO:0090224)2.66021477
115galactose catabolic process (GO:0019388)2.65384806
116regulation of meiosis I (GO:0060631)2.64760257
117body morphogenesis (GO:0010171)2.64018798
118negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.62847622
119negative regulation of translation, ncRNA-mediated (GO:0040033)2.62847622
120regulation of translation, ncRNA-mediated (GO:0045974)2.62847622
121apical protein localization (GO:0045176)2.62535423
122regulation of mesoderm development (GO:2000380)2.61722884
123regulation of cell fate commitment (GO:0010453)2.60949853
124negative regulation of chromosome segregation (GO:0051985)2.56828203
125otic vesicle formation (GO:0030916)2.55716022
126epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.55609289
127regulation of catenin import into nucleus (GO:0035412)2.55453946
128rRNA methylation (GO:0031167)2.54281928
129spindle checkpoint (GO:0031577)2.53576715
130heterochromatin organization (GO:0070828)2.52810758
131negative regulation of protein ubiquitination (GO:0031397)2.52078475
132protein neddylation (GO:0045116)2.51811798
133negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.51311618
134negative regulation of mitotic sister chromatid separation (GO:2000816)2.50946367
135negative regulation of mitotic sister chromatid segregation (GO:0033048)2.50946367
136negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.50946367
137negative regulation of sister chromatid segregation (GO:0033046)2.50946367
138termination of RNA polymerase I transcription (GO:0006363)2.50744199
139serine family amino acid catabolic process (GO:0009071)2.50150264
140methionine metabolic process (GO:0006555)2.49610221
141fusion of sperm to egg plasma membrane (GO:0007342)2.49062554
142establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.48650844
143chromatin remodeling at centromere (GO:0031055)2.47908672
144regulation of chromatin silencing (GO:0031935)2.47125553
145embryonic foregut morphogenesis (GO:0048617)2.43868655
146hippo signaling (GO:0035329)2.43816367
147regulation of stem cell maintenance (GO:2000036)2.43104800
148establishment of integrated proviral latency (GO:0075713)2.42780275
149axonemal dynein complex assembly (GO:0070286)2.39469347
150planar cell polarity pathway involved in neural tube closure (GO:0090179)2.38973674
151gap junction assembly (GO:0016264)2.38712366
152negative regulation of cell fate commitment (GO:0010454)2.33417282
153epithelial cilium movement (GO:0003351)2.33159461
154glycerophospholipid catabolic process (GO:0046475)2.32767225
155neuron cell-cell adhesion (GO:0007158)2.32703493
156establishment of monopolar cell polarity (GO:0061162)2.31718536
157establishment or maintenance of monopolar cell polarity (GO:0061339)2.31718536
158CENP-A containing nucleosome assembly (GO:0034080)2.31090801
159establishment of apical/basal cell polarity (GO:0035089)2.30990879
160establishment or maintenance of bipolar cell polarity (GO:0061245)2.30802978
161establishment or maintenance of apical/basal cell polarity (GO:0035088)2.30802978
162inner ear receptor cell development (GO:0060119)2.30295520
163histone exchange (GO:0043486)2.28371625
164gastrulation with mouth forming second (GO:0001702)2.27951727
165cilium movement (GO:0003341)2.27468094
166digestive tract morphogenesis (GO:0048546)2.27373867
167regulation of DNA methylation (GO:0044030)2.23932302
168negative regulation of cardiac muscle tissue development (GO:0055026)2.22855271
169nonmotile primary cilium assembly (GO:0035058)2.19400237
170establishment of planar polarity (GO:0001736)2.19054227
171establishment of tissue polarity (GO:0007164)2.19054227
172outer ear morphogenesis (GO:0042473)2.18018609
173regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.17819241
174reproductive system development (GO:0061458)2.17108781
175vocalization behavior (GO:0071625)2.15999999
176pituitary gland development (GO:0021983)2.15716086
177protein localization to kinetochore (GO:0034501)2.15259652
178negative regulation of protein localization to cell surface (GO:2000009)2.15139138
179prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060522.14859742
180G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.12693627
181postsynaptic membrane organization (GO:0001941)2.11079971
182negative regulation of androgen receptor signaling pathway (GO:0060766)2.10975618
183embryonic axis specification (GO:0000578)2.10370871
184branching involved in salivary gland morphogenesis (GO:0060445)2.09865579
185L-alpha-amino acid transmembrane transport (GO:1902475)2.09506419
186innervation (GO:0060384)2.09005508
187DNA replication-independent nucleosome organization (GO:0034724)2.07379329
188DNA replication-independent nucleosome assembly (GO:0006336)2.07379329
189embryonic pattern specification (GO:0009880)2.05472361
190somite rostral/caudal axis specification (GO:0032525)2.04576920
191negative regulation of cardiac muscle tissue growth (GO:0055022)2.03939751
192negative regulation of heart growth (GO:0061117)2.03939751
193negative regulation of norepinephrine secretion (GO:0010700)2.03249484
194negative regulation of organ growth (GO:0046621)2.00717580

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.46628713
2EZH2_22144423_ChIP-Seq_EOC_Human3.39317385
3MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse3.30900869
4NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.12481137
5JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.12165358
6MYC_18555785_ChIP-Seq_MESCs_Mouse3.08891825
7NANOG_18700969_ChIP-ChIP_MESCs_Mouse3.04626072
8POU5F1_18700969_ChIP-ChIP_MESCs_Mouse3.04571326
9HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.00387072
10ETS1_20019798_ChIP-Seq_JURKAT_Human2.96183005
11MYC_19079543_ChIP-ChIP_MESCs_Mouse2.62136044
12KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.61737147
13NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.60998078
14KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.56786533
15KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.56786533
16KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.56786533
17TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.53148033
18CREB1_15753290_ChIP-ChIP_HEK293T_Human2.52483101
19GABP_17652178_ChIP-ChIP_JURKAT_Human2.48394864
20ZNF263_19887448_ChIP-Seq_K562_Human2.48009357
21GBX2_23144817_ChIP-Seq_PC3_Human2.47899298
22EST1_17652178_ChIP-ChIP_JURKAT_Human2.47216056
23MYC_18358816_ChIP-ChIP_MESCs_Mouse2.46313488
24ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.46269900
25NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.43287243
26MYC_19030024_ChIP-ChIP_MESCs_Mouse2.33146239
27NANOG_18555785_ChIP-Seq_MESCs_Mouse2.32832611
28SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.26163038
29SALL1_21062744_ChIP-ChIP_HESCs_Human2.25464005
30PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.22884574
31RBPJ_22232070_ChIP-Seq_NCS_Mouse2.17061413
32EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.16819231
33POU5F1_16153702_ChIP-ChIP_HESCs_Human2.14366174
34CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.09838283
35STAT3_1855785_ChIP-Seq_MESCs_Mouse2.06274869
36YY1_21170310_ChIP-Seq_MESCs_Mouse2.06269564
37E2F1_18555785_ChIP-Seq_MESCs_Mouse2.03186616
38POU5F1_18555785_ChIP-Seq_MESCs_Mouse2.03084742
39FOXM1_23109430_ChIP-Seq_U2OS_Human2.00021491
40TCF3_18692474_ChIP-Seq_MEFs_Mouse1.96478106
41AR_21909140_ChIP-Seq_LNCAP_Human1.94685175
42KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.94306671
43NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.93070441
44NELFA_20434984_ChIP-Seq_ESCs_Mouse1.89170932
45FUS_26573619_Chip-Seq_HEK293_Human1.86538288
46FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.76436369
47P300_19829295_ChIP-Seq_ESCs_Human1.74590340
48TAF15_26573619_Chip-Seq_HEK293_Human1.74491601
49VDR_23849224_ChIP-Seq_CD4+_Human1.74367935
50TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.71605741
51GATA1_26923725_Chip-Seq_HPCs_Mouse1.71536037
52KLF4_18555785_ChIP-Seq_MESCs_Mouse1.70282892
53E2F7_22180533_ChIP-Seq_HELA_Human1.70094458
54EWS_26573619_Chip-Seq_HEK293_Human1.69670498
55MYCN_18555785_ChIP-Seq_MESCs_Mouse1.67232770
56RNF2_27304074_Chip-Seq_NSC_Mouse1.66866001
57SOX2_16153702_ChIP-ChIP_HESCs_Human1.65133615
58GABP_19822575_ChIP-Seq_HepG2_Human1.63542227
59DCP1A_22483619_ChIP-Seq_HELA_Human1.60827187
60POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.59282647
61BMI1_23680149_ChIP-Seq_NPCS_Mouse1.59106376
62NANOG_16153702_ChIP-ChIP_HESCs_Human1.57068040
63NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.55517140
64TCF3_18692474_ChIP-Seq_MESCs_Mouse1.55329549
65OCT4_18692474_ChIP-Seq_MEFs_Mouse1.55329425
66PIAS1_25552417_ChIP-Seq_VCAP_Human1.55021308
67CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.53440845
68TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.52874926
69XRN2_22483619_ChIP-Seq_HELA_Human1.51669098
70KDM5A_27292631_Chip-Seq_BREAST_Human1.51504188
71NANOG_18692474_ChIP-Seq_MEFs_Mouse1.49242844
72TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.48173720
73POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.48173720
74VDR_22108803_ChIP-Seq_LS180_Human1.47437259
75HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.43051074
76TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse1.42632200
77CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.42535303
78SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.41859440
79NANOG_21062744_ChIP-ChIP_HESCs_Human1.41841388
80EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.41179022
81ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.40970150
82E2F4_17652178_ChIP-ChIP_JURKAT_Human1.40891098
83SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.39269956
84GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.38380676
85POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.37743529
86SOX2_18692474_ChIP-Seq_MEFs_Mouse1.37230499
87RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.37103226
88STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.35506575
89TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.35438246
90POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.35268513
91THAP11_20581084_ChIP-Seq_MESCs_Mouse1.33788045
92CTBP2_25329375_ChIP-Seq_LNCAP_Human1.33355335
93GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.31116328
94POU5F1_16518401_ChIP-PET_MESCs_Mouse1.30471914
95FOXP3_21729870_ChIP-Seq_TREG_Human1.28643561
96SMAD3_21741376_ChIP-Seq_EPCs_Human1.28100867
97ISL1_27105846_Chip-Seq_CPCs_Mouse1.27906638
98EZH2_27304074_Chip-Seq_ESCs_Mouse1.27816475
99RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.27666522
100TBX3_20139965_ChIP-Seq_MESCs_Mouse1.27586118
101TBX3_20139965_ChIP-Seq_ESCs_Mouse1.27235919
102CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.27135731
103TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.25398208
104TOP2B_26459242_ChIP-Seq_MCF-7_Human1.24689611
105KAP1_27257070_Chip-Seq_ESCs_Mouse1.24046279
106AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.23508717
107SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.23078683
108CTBP1_25329375_ChIP-Seq_LNCAP_Human1.23012737
109NANOG_16518401_ChIP-PET_MESCs_Mouse1.22708393
110NANOG_18692474_ChIP-Seq_MESCs_Mouse1.22517788
111ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.22397328
112SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.21789723
113MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.21671623
114KAP1_22055183_ChIP-Seq_ESCs_Mouse1.21664168
115SOX2_18555785_ChIP-Seq_MESCs_Mouse1.21233730
116SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.20776562
117EED_16625203_ChIP-ChIP_MESCs_Mouse1.20466704
118PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.20213334
119HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.20206961
120MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.19840342
121SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.19232482
122SMAD4_21799915_ChIP-Seq_A2780_Human1.17580917
123DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.16738108
124TTF2_22483619_ChIP-Seq_HELA_Human1.16631389
125SRF_21415370_ChIP-Seq_HL-1_Mouse1.15794050
126EZH2_18974828_ChIP-Seq_MESCs_Mouse1.15680261
127RNF2_18974828_ChIP-Seq_MESCs_Mouse1.15680261
128ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.15592611
129ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.14980145
130POU3F2_20337985_ChIP-ChIP_501MEL_Human1.14500777
131BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.13664700
132NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.13621480
133PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.11861580
134SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.11165426
135REST_21632747_ChIP-Seq_MESCs_Mouse1.10753085
136PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.09720260
137SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.09420416
138UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.09195436
139CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09191509
140WT1_19549856_ChIP-ChIP_CCG9911_Human1.08681787
141SMAD3_21741376_ChIP-Seq_HESCs_Human1.08645296
142SALL4_18804426_ChIP-ChIP_XEN_Mouse1.08497179
143ZFX_18555785_ChIP-Seq_MESCs_Mouse1.08426722
144KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.08099793
145SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.07601497
146OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.07574502
147TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.07207892
148ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.06917004
149ZFP57_27257070_Chip-Seq_ESCs_Mouse1.06745387
150PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.06437311
151JARID2_20064375_ChIP-Seq_MESCs_Mouse1.05780473
152SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.04842571
153YAP1_20516196_ChIP-Seq_MESCs_Mouse1.03975258
154SMAD3_21741376_ChIP-Seq_ESCs_Human1.03125111
155RNF2_27304074_Chip-Seq_ESCs_Mouse1.02317243
156SOX2_18692474_ChIP-Seq_MESCs_Mouse1.01356658
157RING1B_27294783_Chip-Seq_NPCs_Mouse1.01285958
158RUNX2_22187159_ChIP-Seq_PCA_Human1.01108054
159GATA3_20176728_ChIP-ChIP_TSCs_Mouse1.01070822
160TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.00688393
161ATF3_27146783_Chip-Seq_COLON_Human1.00313591
162SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.00248565
163KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.99659071
164KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.99399120
165PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.98892083
166CBX2_27304074_Chip-Seq_ESCs_Mouse0.97767807
167CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.97051120
168RING1B_27294783_Chip-Seq_ESCs_Mouse0.97045689
169AR_21572438_ChIP-Seq_LNCaP_Human0.96448712
170SMAD4_21741376_ChIP-Seq_HESCs_Human0.95871826
171YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.94476337
172LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94261556
173SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.94105896
174ERG_21242973_ChIP-ChIP_JURKAT_Human0.94016200
175SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.93762659
176TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.93375560
177SRY_22984422_ChIP-ChIP_TESTIS_Rat0.91929793
178TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.91530594
179ELK1_22589737_ChIP-Seq_MCF10A_Human0.90592071
180TET1_21451524_ChIP-Seq_MESCs_Mouse0.89511090
181SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.88502087
182ESR2_21235772_ChIP-Seq_MCF-7_Human0.87148405

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.47881431
2MP0009840_abnormal_foam_cell4.69483116
3MP0004957_abnormal_blastocyst_morpholog3.99479765
4MP0003111_abnormal_nucleus_morphology3.87038331
5MP0005670_abnormal_white_adipose3.72537366
6MP0003718_maternal_effect3.29680218
7MP0003941_abnormal_skin_development3.11577141
8MP0000566_synostosis2.92010960
9MP0003136_yellow_coat_color2.72434112
10MP0003878_abnormal_ear_physiology2.68850717
11MP0005377_hearing/vestibular/ear_phenot2.68850717
12MP0008260_abnormal_autophagy2.35776711
13MP0010030_abnormal_orbit_morphology2.28595094
14MP0003646_muscle_fatigue2.28272627
15MP0003077_abnormal_cell_cycle2.24832389
16MP0004019_abnormal_vitamin_homeostasis2.22094288
17MP0003122_maternal_imprinting2.19593330
18MP0001661_extended_life_span2.04240484
19MP0010352_gastrointestinal_tract_polyps2.03372183
20MP0001727_abnormal_embryo_implantation2.02583088
21MP0005410_abnormal_fertilization1.99288030
22MP0006292_abnormal_olfactory_placode1.94042831
23MP0000537_abnormal_urethra_morphology1.92045706
24MP0003937_abnormal_limbs/digits/tail_de1.88642963
25MP0000579_abnormal_nail_morphology1.86864608
26MP0001756_abnormal_urination1.85953876
27MP0008932_abnormal_embryonic_tissue1.84348010
28MP0003195_calcinosis1.84294764
29MP0001293_anophthalmia1.83317938
30MP0008877_abnormal_DNA_methylation1.82166012
31MP0001730_embryonic_growth_arrest1.81395297
32MP0005395_other_phenotype1.80651816
33MP0003786_premature_aging1.80365646
34MP0010094_abnormal_chromosome_stability1.80124322
35MP0001919_abnormal_reproductive_system1.73295758
36MP0003567_abnormal_fetal_cardiomyocyte1.70913006
37MP0005389_reproductive_system_phenotype1.69116387
38MP0002876_abnormal_thyroid_physiology1.66548240
39MP0000778_abnormal_nervous_system1.65959938
40MP0003186_abnormal_redox_activity1.65002055
41MP0005332_abnormal_amino_acid1.64937814
42MP0005666_abnormal_adipose_tissue1.64732767
43MP0008057_abnormal_DNA_replication1.64362216
44MP0005451_abnormal_body_composition1.62783179
45MP0001672_abnormal_embryogenesis/_devel1.62284992
46MP0005380_embryogenesis_phenotype1.62284992
47MP0002697_abnormal_eye_size1.60748500
48MP0002653_abnormal_ependyma_morphology1.56055301
49MP0001929_abnormal_gametogenesis1.55637855
50MP0003121_genomic_imprinting1.55385405
51MP0002233_abnormal_nose_morphology1.55125406
52MP0008058_abnormal_DNA_repair1.53483728
53MP0001984_abnormal_olfaction1.53035987
54MP0002160_abnormal_reproductive_system1.50905356
55MP0003806_abnormal_nucleotide_metabolis1.50593304
56MP0005394_taste/olfaction_phenotype1.50208068
57MP0005499_abnormal_olfactory_system1.50208068
58MP0002254_reproductive_system_inflammat1.48882708
59MP0009672_abnormal_birth_weight1.48045976
60MP0008789_abnormal_olfactory_epithelium1.47774294
61MP0003315_abnormal_perineum_morphology1.46429792
62MP0002210_abnormal_sex_determination1.45037184
63MP0004185_abnormal_adipocyte_glucose1.43395817
64MP0001188_hyperpigmentation1.42176693
65MP0001299_abnormal_eye_distance/1.40521459
66MP0005075_abnormal_melanosome_morpholog1.39636890
67MP0004381_abnormal_hair_follicle1.39274857
68MP0002088_abnormal_embryonic_growth/wei1.38302079
69MP0003984_embryonic_growth_retardation1.36903982
70MP0004270_analgesia1.36796449
71MP0001286_abnormal_eye_development1.36297556
72MP0002086_abnormal_extraembryonic_tissu1.35950904
73MP0006035_abnormal_mitochondrial_morpho1.35157425
74MP0000049_abnormal_middle_ear1.32347519
75MP0003861_abnormal_nervous_system1.31760302
76MP0001145_abnormal_male_reproductive1.31398330
77MP0001697_abnormal_embryo_size1.30644825
78MP0002736_abnormal_nociception_after1.29186460
79MP0000631_abnormal_neuroendocrine_gland1.24748557
80MP0003880_abnormal_central_pattern1.17645779
81MP0000358_abnormal_cell_content/1.16711959
82MP0001764_abnormal_homeostasis1.16062002
83MP0009703_decreased_birth_body1.15939333
84MP0003942_abnormal_urinary_system1.15233051
85MP0003787_abnormal_imprinting1.14392789
86MP0003283_abnormal_digestive_organ1.13719151
87MP0002085_abnormal_embryonic_tissue1.13180616
88MP0003698_abnormal_male_reproductive1.13134282
89MP0004859_abnormal_synaptic_plasticity1.13108065
90MP0010329_abnormal_lipoprotein_level1.12233689
91MP0002734_abnormal_mechanical_nocicepti1.10604730
92MP0002938_white_spotting1.10354276
93MP0006276_abnormal_autonomic_nervous1.10012495
94MP0003119_abnormal_digestive_system1.09635592
95MP0009053_abnormal_anal_canal1.09252613
96MP0002080_prenatal_lethality1.08517691
97MP0000653_abnormal_sex_gland1.06990600
98MP0001485_abnormal_pinna_reflex1.06334057
99MP0002796_impaired_skin_barrier1.05595293
100MP0009643_abnormal_urine_homeostasis1.05386447
101MP0000762_abnormal_tongue_morphology1.04414324
102MP0000428_abnormal_craniofacial_morphol1.02513158
103MP0002084_abnormal_developmental_patter1.00760652
104MP0002102_abnormal_ear_morphology0.99152753
105MP0009379_abnormal_foot_pigmentation0.98883548
106MP0005375_adipose_tissue_phenotype0.98354850
107MP0002822_catalepsy0.98249726
108MP0003755_abnormal_palate_morphology0.98152451
109MP0002638_abnormal_pupillary_reflex0.97328437
110MP0001486_abnormal_startle_reflex0.96988911
111MP0001177_atelectasis0.96744370
112MP0004272_abnormal_basement_membrane0.94850309
113MP0003890_abnormal_embryonic-extraembry0.94481364
114MP0000350_abnormal_cell_proliferation0.94008593
115MP0003938_abnormal_ear_development0.93702589
116MP0002295_abnormal_pulmonary_circulatio0.93622573
117MP0003935_abnormal_craniofacial_develop0.93612304
118MP0002161_abnormal_fertility/fecundity0.93212440
119MP0004264_abnormal_extraembryonic_tissu0.93164473
120MP0003635_abnormal_synaptic_transmissio0.92108376
121MP0003879_abnormal_hair_cell0.90801006
122MP0005187_abnormal_penis_morphology0.90675880
123MP0004885_abnormal_endolymph0.90328603
124MP0006036_abnormal_mitochondrial_physio0.88860094
125MP0002089_abnormal_postnatal_growth/wei0.88657346
126MP0000955_abnormal_spinal_cord0.87896593
127MP0002111_abnormal_tail_morphology0.87619069
128MP0004133_heterotaxia0.87538025
129MP0003123_paternal_imprinting0.86025069
130MP0002152_abnormal_brain_morphology0.85977322
131MP0003699_abnormal_female_reproductive0.85463632
132MP0004084_abnormal_cardiac_muscle0.85074469
133MP0002168_other_aberrant_phenotype0.85060521
134MP0000383_abnormal_hair_follicle0.84751832
135MP0000013_abnormal_adipose_tissue0.84534830
136MP0000647_abnormal_sebaceous_gland0.83576693
137MP0000432_abnormal_head_morphology0.82821063
138MP0002272_abnormal_nervous_system0.82451043
139MP0001968_abnormal_touch/_nociception0.82090492
140MP0003936_abnormal_reproductive_system0.81256083
141MP0006138_congestive_heart_failure0.80953708
142MP0002970_abnormal_white_adipose0.80854548
143MP0004484_altered_response_of0.80053939
144MP0002557_abnormal_social/conspecific_i0.79226025
145MP0000609_abnormal_liver_physiology0.78399566
146MP0002139_abnormal_hepatobiliary_system0.78055554
147MP0002332_abnormal_exercise_endurance0.77959778
148MP0002971_abnormal_brown_adipose0.76975740
149MP0002249_abnormal_larynx_morphology0.76721404
150MP0002081_perinatal_lethality0.76667909
151MP0002063_abnormal_learning/memory/cond0.76521041
152MP0008995_early_reproductive_senescence0.76176477
153MP0002572_abnormal_emotion/affect_behav0.75841399
154MP0005365_abnormal_bile_salt0.75650595
155MP0004130_abnormal_muscle_cell0.75546876
156MP0000534_abnormal_ureter_morphology0.74266647
157MP0002092_abnormal_eye_morphology0.73949233
158MP0003385_abnormal_body_wall0.73702648
159MP0002735_abnormal_chemical_nociception0.73442695
160MP0003115_abnormal_respiratory_system0.71918214
161MP0002127_abnormal_cardiovascular_syste0.70843661
162MP0009115_abnormal_fat_cell0.69689906
163MP0000627_abnormal_mammary_gland0.69616711
164MP0005085_abnormal_gallbladder_physiolo0.68644095
165MP0002118_abnormal_lipid_homeostasis0.68632866
166MP0008875_abnormal_xenobiotic_pharmacok0.66282933
167MP0001119_abnormal_female_reproductive0.65984588
168MP0010234_abnormal_vibrissa_follicle0.65938786
169MP0005266_abnormal_metabolism0.64692195
170MP0001542_abnormal_bone_strength0.64032261
171MP0002136_abnormal_kidney_physiology0.63551756
172MP0003566_abnormal_cell_adhesion0.62855330
173MP0004782_abnormal_surfactant_physiolog0.59274883

Predicted human phenotypes

RankGene SetZ-score
1Breast hypoplasia (HP:0003187)4.52389408
2Hyperglycinuria (HP:0003108)4.15974224
3Prolonged neonatal jaundice (HP:0006579)4.02109782
4Hyperlipoproteinemia (HP:0010980)3.82875825
5Premature ovarian failure (HP:0008209)3.77275521
6Ileus (HP:0002595)3.75146664
7Septo-optic dysplasia (HP:0100842)3.69932132
8Birth length less than 3rd percentile (HP:0003561)3.65256261
9Hyperglycinemia (HP:0002154)3.64716034
10Hepatoblastoma (HP:0002884)3.51450148
11Abnormality of serine family amino acid metabolism (HP:0010894)3.49080773
12Abnormality of glycine metabolism (HP:0010895)3.49080773
13Carpal bone hypoplasia (HP:0001498)3.41984620
14Cerebral hypomyelination (HP:0006808)3.40673392
15Hypoalphalipoproteinemia (HP:0003233)3.33700015
16Secondary amenorrhea (HP:0000869)3.29300990
17Multiple enchondromatosis (HP:0005701)3.15510839
18Myopathic facies (HP:0002058)3.05705400
19Muscle fibrillation (HP:0010546)2.93856109
20Abnormality of glycosphingolipid metabolism (HP:0004343)2.89040251
21Abnormality of glycolipid metabolism (HP:0010969)2.89040251
22Abnormality of liposaccharide metabolism (HP:0010968)2.89040251
23Megaloblastic anemia (HP:0001889)2.87473912
24Athetosis (HP:0002305)2.86473155
25Tongue fasciculations (HP:0001308)2.84148576
26Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.83921220
27Impulsivity (HP:0100710)2.82135181
28Absent radius (HP:0003974)2.81270565
29Osteomalacia (HP:0002749)2.80568609
30Aplasia/Hypoplasia involving the musculature (HP:0001460)2.80267512
31Chronic bronchitis (HP:0004469)2.79499333
32Testicular atrophy (HP:0000029)2.75309382
33Male infertility (HP:0003251)2.74859624
34Absent hand (HP:0004050)2.72929583
35Abnormality of serum amino acid levels (HP:0003112)2.71463296
36Coronal craniosynostosis (HP:0004440)2.71143007
37Proximal tubulopathy (HP:0000114)2.69573576
38Ureteral duplication (HP:0000073)2.67921119
39Rough bone trabeculation (HP:0100670)2.64269688
40Aplasia/hypoplasia of the humerus (HP:0006507)2.63047736
41Aplasia involving forearm bones (HP:0009822)2.62439157
42Absent forearm bone (HP:0003953)2.62439157
43Hyperammonemia (HP:0001987)2.60878172
44Abnormality of dicarboxylic acid metabolism (HP:0010995)2.60082724
45Dicarboxylic aciduria (HP:0003215)2.60082724
46Insulin-resistant diabetes mellitus (HP:0000831)2.58688493
47Esophageal atresia (HP:0002032)2.57236667
48Lethargy (HP:0001254)2.56650278
49Colon cancer (HP:0003003)2.54724063
50Abnormal spermatogenesis (HP:0008669)2.53834116
51Aplasia involving bones of the upper limbs (HP:0009823)2.52828967
52Aplasia of the phalanges of the hand (HP:0009802)2.52828967
53Aplasia involving bones of the extremities (HP:0009825)2.52828967
54Partial duplication of thumb phalanx (HP:0009944)2.52330801
55Progressive muscle weakness (HP:0003323)2.50650395
56Azoospermia (HP:0000027)2.50352259
57Absent septum pellucidum (HP:0001331)2.50029389
58Nausea (HP:0002018)2.46472313
59Optic nerve hypoplasia (HP:0000609)2.44015313
603-Methylglutaconic aciduria (HP:0003535)2.43614815
61Gout (HP:0001997)2.40806802
62Choanal stenosis (HP:0000452)2.40562596
63Maternal diabetes (HP:0009800)2.40153142
64Polycythemia (HP:0001901)2.39898283
65CNS hypomyelination (HP:0003429)2.35865291
66Abnormality of permanent molar morphology (HP:0011071)2.35728248
67Abnormality of the dental root (HP:0006486)2.35728248
68Taurodontia (HP:0000679)2.35728248
69Cutaneous finger syndactyly (HP:0010554)2.35499311
70Short hallux (HP:0010109)2.33432747
71Death in infancy (HP:0001522)2.32587252
72Sparse eyelashes (HP:0000653)2.31420406
73Long foot (HP:0001833)2.31211692
74Cheilitis (HP:0100825)2.29868723
75Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.29841510
76Abnormality of the middle phalanges of the toes (HP:0010183)2.29493540
77Xanthomatosis (HP:0000991)2.28970547
78Difficulty climbing stairs (HP:0003551)2.28771801
79Hypolipoproteinemia (HP:0010981)2.28592927
80Bronchomalacia (HP:0002780)2.27984263
81Abnormality of the umbilical cord (HP:0010881)2.27949975
82Cutaneous syndactyly (HP:0012725)2.27681416
83Patellar aplasia (HP:0006443)2.25534387
84Preaxial foot polydactyly (HP:0001841)2.25336885
85Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.25144989
86Abnormality of alanine metabolism (HP:0010916)2.25144989
87Hyperalaninemia (HP:0003348)2.25144989
88Aplasia/Hypoplasia of the patella (HP:0006498)2.24404046
89Turricephaly (HP:0000262)2.24159976
90Abnormality of the septum pellucidum (HP:0007375)2.23830766
91Hyperglycemia (HP:0003074)2.20481750
92Abnormal ciliary motility (HP:0012262)2.20018421
93Aplasia/Hypoplasia of the hallux (HP:0008362)2.18869445
94Concave nail (HP:0001598)2.16086177
95Abnormal respiratory motile cilium physiology (HP:0012261)2.16018543
96Abnormal respiratory motile cilium morphology (HP:0005938)2.15681591
97Abnormal respiratory epithelium morphology (HP:0012253)2.15681591
98Abnormality of molar morphology (HP:0011070)2.15048761
99Abnormality of molar (HP:0011077)2.15048761
100Vaginal atresia (HP:0000148)2.14745668
101Partial duplication of the phalanx of hand (HP:0009999)2.14024601
102Anophthalmia (HP:0000528)2.13793180
103Microretrognathia (HP:0000308)2.13767269
104Abnormality of the dental pulp (HP:0006479)2.13369502
105Bilateral microphthalmos (HP:0007633)2.13127618
106Rhabdomyosarcoma (HP:0002859)2.11565204
107Genital tract atresia (HP:0001827)2.09901422
108Absent eyebrow (HP:0002223)2.09609403
109Hypertriglyceridemia (HP:0002155)2.08233841
110Patent foramen ovale (HP:0001655)2.08023790
111Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.07301590
112Esophageal varix (HP:0002040)2.06932146
113Myokymia (HP:0002411)2.06312060
114Aplasia/Hypoplasia of the sternum (HP:0006714)2.05936010
115Spastic diplegia (HP:0001264)2.04797785
116Congenital, generalized hypertrichosis (HP:0004540)2.04434952
117Short humerus (HP:0005792)2.04157601
118Rhinitis (HP:0012384)2.02978944
119Dynein arm defect of respiratory motile cilia (HP:0012255)2.02253904
120Absent/shortened dynein arms (HP:0200106)2.02253904
121Seborrheic dermatitis (HP:0001051)2.01913360
122Labial hypoplasia (HP:0000066)2.00732635
123Methylmalonic aciduria (HP:0012120)2.00040895
124Delusions (HP:0000746)1.99309756
125Gastrointestinal atresia (HP:0002589)1.98565577
126Degeneration of anterior horn cells (HP:0002398)1.97416395
127Abnormality of the anterior horn cell (HP:0006802)1.97416395
128Abnormality of the labia minora (HP:0012880)1.97005552
129Gonadotropin excess (HP:0000837)1.96828401
130Absent thumb (HP:0009777)1.96782896
131Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.94392068
132Shawl scrotum (HP:0000049)1.93886991
133Midline defect of the nose (HP:0004122)1.92860232
134Increased mean platelet volume (HP:0011877)1.92755510
135Split foot (HP:0001839)1.91844968
136Aqueductal stenosis (HP:0002410)1.90794973
137Hypoplastic female external genitalia (HP:0012815)1.90104515
138Abnormal trabecular bone morphology (HP:0100671)1.89830184
139Papillary thyroid carcinoma (HP:0002895)1.89126151
140Personality changes (HP:0000751)1.87448661
141Stenosis of the external auditory canal (HP:0000402)1.86073372
142Abnormality of the lacrimal duct (HP:0011481)1.85591383
143Hypoglycemic coma (HP:0001325)1.84847393
144Bifid tongue (HP:0010297)1.84047032
145Abdominal situs inversus (HP:0003363)1.81238034
146Abnormality of abdominal situs (HP:0011620)1.81238034
147Absent eyelashes (HP:0000561)1.80624964
148Unsteady gait (HP:0002317)1.80265721
149Septate vagina (HP:0001153)1.79019210
150Cupped ear (HP:0000378)1.78521519
151Cortical dysplasia (HP:0002539)1.78306591
152Broad foot (HP:0001769)1.77820165
153Scrotal hypoplasia (HP:0000046)1.77712459
154Microvesicular hepatic steatosis (HP:0001414)1.76282517
155CNS demyelination (HP:0007305)1.76085798
156High anterior hairline (HP:0009890)1.74478986
157Hypoglycemic seizures (HP:0002173)1.73684667
158Myelomeningocele (HP:0002475)1.73089020
159Acanthosis nigricans (HP:0000956)1.72339337
160Abnormality of the aortic arch (HP:0012303)1.72328693
161Hyperuricemia (HP:0002149)1.71613394
162Increased purine levels (HP:0004368)1.71613394
163Supernumerary spleens (HP:0009799)1.71516912
164Omphalocele (HP:0001539)1.71496863
165Nephroblastoma (Wilms tumor) (HP:0002667)1.71443177
166Abnormality of fatty-acid metabolism (HP:0004359)1.71353091
167Oral leukoplakia (HP:0002745)1.71168984
168Broad metatarsal (HP:0001783)1.71160077
169Absent hair (HP:0002298)1.66624494
170Breast aplasia (HP:0100783)1.66247560
171Abnormal pancreas size (HP:0012094)1.65573894
172Gait imbalance (HP:0002141)1.65491734
173Duplication of thumb phalanx (HP:0009942)1.64506483
174Sleep apnea (HP:0010535)1.64227044
175Shallow orbits (HP:0000586)1.62358951
176Depressed nasal tip (HP:0000437)1.62135614
177Synostosis involving the elbow (HP:0003938)1.61240612
178Humeroradial synostosis (HP:0003041)1.61240612
1792-3 toe syndactyly (HP:0004691)1.60974493
180Abnormal lung lobation (HP:0002101)1.59885029
181Bifid scrotum (HP:0000048)1.59745575
182Embryonal renal neoplasm (HP:0011794)1.59381375
183Aplasia/Hypoplasia of the breasts (HP:0010311)1.59101708
184Poor coordination (HP:0002370)1.59065343
185Abnormality of the salivary glands (HP:0010286)1.55228166
186Abnormality of the nasolacrimal system (HP:0000614)1.55006935
187Congenital primary aphakia (HP:0007707)1.54062014
188Infertility (HP:0000789)1.53333887
189Vertebral arch anomaly (HP:0008438)1.52751153

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA28.33681640
2BUB14.61743571
3WEE13.76688498
4AKT33.09846738
5TNIK2.95260645
6PDK42.79065162
7PDK32.79065162
8CASK2.75626753
9PNCK2.68714702
10TTK2.53027260
11STK38L2.45946735
12FGFR22.42874916
13PDK22.17717503
14MKNK22.11223123
15BMPR1B2.05912288
16PLK42.04972634
17NEK21.91401125
18RPS6KB21.85250796
19MKNK11.83366985
20TSSK61.81945549
21CAMK1G1.81656434
22NEK11.71923610
23KDR1.70199124
24CDK191.67358543
25BMX1.64176350
26NLK1.58442355
27TAF11.56336988
28MAP3K41.53253532
29MAPK151.50216531
30LATS21.44839407
31STK381.42444411
32SRPK11.40726291
33STK161.36139000
34MST41.34505631
35ARAF1.34281229
36MAP3K101.30682478
37PLK11.28670292
38PINK11.27203577
39BRAF1.21928603
40AURKA1.20268474
41FGFR11.19349203
42NTRK11.16274922
43EIF2AK11.12215206
44IRAK31.11441431
45TYRO31.11126177
46OXSR11.09158555
47NME11.07967703
48DMPK1.07592780
49TAOK11.07507373
50NTRK21.06700729
51PRKCI1.06132676
52EPHB21.05953268
53BRSK21.05395181
54NME21.02035163
55MET0.97574959
56ERBB40.97319440
57ZAK0.97284054
58CHEK20.95551727
59MAP3K110.95365056
60DYRK30.94503117
61GRK60.92962170
62BCR0.92225150
63MUSK0.91890478
64MAP2K20.91124000
65TGFBR10.89115568
66EPHA40.89055727
67MAP2K70.87765094
68NUAK10.87610673
69PLK20.86431369
70MAP3K90.85841785
71DYRK1A0.80793041
72TIE10.80661846
73PAK40.76483180
74NTRK30.75915221
75CDK40.75868323
76TRIM280.74502081
77SGK4940.73508286
78SGK2230.73508286
79MARK30.73131685
80CAMK1D0.72787742
81PASK0.72573904
82BCKDK0.70998762
83CSNK1G20.70484022
84PTK20.69547415
85EIF2AK30.67889362
86VRK10.67488380
87PLK30.65033602
88MAPKAPK50.64777530
89PAK10.63891411
90MAP3K120.62047142
91MAP3K80.62018085
92AURKB0.60585956
93BRSK10.60058320
94PRKD30.58713315
95STK100.58447115
96CSNK1G10.57007900
97GRK50.56009715
98VRK20.55709702
99MELK0.55174347
100CAMK2G0.55104735
101LATS10.55053058
102MINK10.54008845
103GRK10.53909936
104MAP3K30.53690888
105TRIB30.52201913
106STK390.52006121
107ATM0.52005771
108PRKCE0.51720814
109CDK70.50827323
110TESK20.50430716
111FGFR40.50022312
112BRD40.49476746
113NEK90.48290730
114YES10.46666459
115MAP2K10.45985679
116MAP3K50.45802692
117STK110.45540629
118STK30.45278680
119CDK90.44859137
120MAP2K40.44382468
121CHEK10.43112508
122UHMK10.42797870
123CSNK1D0.42264867
124CSNK1E0.41646465
125TAOK20.41294270
126ERBB20.41128352
127STK240.40890530
128ALK0.40808680
129PRKDC0.40060475
130ABL20.39774432
131CAMK2B0.39568667
132CDK50.39532704
133ACVR1B0.39390938
134FER0.39231918
135CAMKK20.39049758
136MTOR0.38607059
137IRAK20.38280852
138PRKAA10.37419096
139SGK20.36961535
140DYRK20.36771821
141CDK30.36596728
142WNK30.36514584
143CAMK2A0.35782471
144CSNK1G30.33657551
145PDGFRA0.33288036
146CDK20.33216731
147CSNK2A10.31783452
148CDK120.31092133
149MAPK70.30374897
150RPS6KA40.27836266
151CSNK2A20.27143860
152MAPKAPK30.25686030
153MARK10.25632060
154PRKCG0.25126406
155ZAP700.24099632
156SGK30.23941093
157CDC70.23425917
158PDPK10.23249846
159PIM10.23068117

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030505.15938007
2Vitamin B6 metabolism_Homo sapiens_hsa007503.81673503
3Regulation of autophagy_Homo sapiens_hsa041403.10041998
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.04716769
5RNA polymerase_Homo sapiens_hsa030202.83952065
6RNA transport_Homo sapiens_hsa030132.74419637
7Steroid biosynthesis_Homo sapiens_hsa001002.08519734
8Fructose and mannose metabolism_Homo sapiens_hsa000512.08143547
9Glycerophospholipid metabolism_Homo sapiens_hsa005642.06697949
10Pantothenate and CoA biosynthesis_Homo sapiens_hsa007702.04048152
11Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.93026297
122-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.92338013
13Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.88655681
14Nicotine addiction_Homo sapiens_hsa050331.84224704
15Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.79611325
16Ribosome_Homo sapiens_hsa030101.77880977
17Pentose phosphate pathway_Homo sapiens_hsa000301.69545493
18Pyrimidine metabolism_Homo sapiens_hsa002401.67293571
19Basal transcription factors_Homo sapiens_hsa030221.64531515
20Folate biosynthesis_Homo sapiens_hsa007901.64453270
21Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.63767387
22Glycerolipid metabolism_Homo sapiens_hsa005611.60547053
23Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.55747135
24Wnt signaling pathway_Homo sapiens_hsa043101.51547578
25Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.45472480
26Cell cycle_Homo sapiens_hsa041101.44699828
27Cysteine and methionine metabolism_Homo sapiens_hsa002701.39140485
28Homologous recombination_Homo sapiens_hsa034401.36293585
29Vitamin digestion and absorption_Homo sapiens_hsa049771.36122935
30Mismatch repair_Homo sapiens_hsa034301.35786221
31Oocyte meiosis_Homo sapiens_hsa041141.35759196
32TGF-beta signaling pathway_Homo sapiens_hsa043501.34884289
33Propanoate metabolism_Homo sapiens_hsa006401.29598817
34Spliceosome_Homo sapiens_hsa030401.28895998
35DNA replication_Homo sapiens_hsa030301.28842981
36Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.28385942
37beta-Alanine metabolism_Homo sapiens_hsa004101.27313824
38Carbon metabolism_Homo sapiens_hsa012001.22974663
39Axon guidance_Homo sapiens_hsa043601.22446239
40Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.21219230
41PPAR signaling pathway_Homo sapiens_hsa033201.20204194
42ECM-receptor interaction_Homo sapiens_hsa045121.18590744
43Drug metabolism - other enzymes_Homo sapiens_hsa009831.18550809
44Nucleotide excision repair_Homo sapiens_hsa034201.17359554
45Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.15794494
46Arginine biosynthesis_Homo sapiens_hsa002201.15428242
47Fanconi anemia pathway_Homo sapiens_hsa034601.13994259
48Protein export_Homo sapiens_hsa030601.12940743
49Pentose and glucuronate interconversions_Homo sapiens_hsa000401.12061296
50Glutathione metabolism_Homo sapiens_hsa004801.10630073
51Tight junction_Homo sapiens_hsa045301.08418268
52Base excision repair_Homo sapiens_hsa034101.06358560
53Serotonergic synapse_Homo sapiens_hsa047261.03515944
54Purine metabolism_Homo sapiens_hsa002301.03320672
55Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.99111996
56Hippo signaling pathway_Homo sapiens_hsa043900.97178047
57Biosynthesis of amino acids_Homo sapiens_hsa012300.96350225
58Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.96130577
59Phototransduction_Homo sapiens_hsa047440.95015801
60Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.94757564
61Gap junction_Homo sapiens_hsa045400.94205487
62Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.93591968
63Glutamatergic synapse_Homo sapiens_hsa047240.93084154
64Hedgehog signaling pathway_Homo sapiens_hsa043400.92664463
65Long-term depression_Homo sapiens_hsa047300.91874028
66Arginine and proline metabolism_Homo sapiens_hsa003300.89804891
67Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.87867357
68Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.86628517
69Arachidonic acid metabolism_Homo sapiens_hsa005900.85661165
70Cardiac muscle contraction_Homo sapiens_hsa042600.83780040
71p53 signaling pathway_Homo sapiens_hsa041150.82152090
72Cyanoamino acid metabolism_Homo sapiens_hsa004600.81882940
73Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.81657105
74Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.81268552
75mRNA surveillance pathway_Homo sapiens_hsa030150.80896911
76Linoleic acid metabolism_Homo sapiens_hsa005910.80470681
77GABAergic synapse_Homo sapiens_hsa047270.80278965
78Sulfur relay system_Homo sapiens_hsa041220.79742347
79Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.78347553
80Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.77362826
81Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.76929837
82Melanogenesis_Homo sapiens_hsa049160.76904164
83Taste transduction_Homo sapiens_hsa047420.76536956
84Butanoate metabolism_Homo sapiens_hsa006500.75525538
85Longevity regulating pathway - mammal_Homo sapiens_hsa042110.75038872
86Caffeine metabolism_Homo sapiens_hsa002320.74609192
87Pyruvate metabolism_Homo sapiens_hsa006200.74453497
88Galactose metabolism_Homo sapiens_hsa000520.74065191
89Epstein-Barr virus infection_Homo sapiens_hsa051690.71626147
90alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.70226905
91Circadian rhythm_Homo sapiens_hsa047100.70159279
92Huntingtons disease_Homo sapiens_hsa050160.69937237
93Fat digestion and absorption_Homo sapiens_hsa049750.69412639
94Maturity onset diabetes of the young_Homo sapiens_hsa049500.68480585
95Fatty acid biosynthesis_Homo sapiens_hsa000610.68282276
96Peroxisome_Homo sapiens_hsa041460.68083284
97Rap1 signaling pathway_Homo sapiens_hsa040150.68080639
98Bile secretion_Homo sapiens_hsa049760.67116148
99Cocaine addiction_Homo sapiens_hsa050300.66871927
100Selenocompound metabolism_Homo sapiens_hsa004500.66735464
101Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.66723254
102Fatty acid elongation_Homo sapiens_hsa000620.66431895
103Fatty acid metabolism_Homo sapiens_hsa012120.65673338
104AMPK signaling pathway_Homo sapiens_hsa041520.65597602
105Metabolic pathways_Homo sapiens_hsa011000.65338843
106Insulin secretion_Homo sapiens_hsa049110.64756228
107RNA degradation_Homo sapiens_hsa030180.63309694
108Collecting duct acid secretion_Homo sapiens_hsa049660.62915661
109Colorectal cancer_Homo sapiens_hsa052100.61025721
110Dopaminergic synapse_Homo sapiens_hsa047280.60430441
111Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.59830734
112Circadian entrainment_Homo sapiens_hsa047130.59365527
113Amphetamine addiction_Homo sapiens_hsa050310.58245130
114Mineral absorption_Homo sapiens_hsa049780.58148619
115mTOR signaling pathway_Homo sapiens_hsa041500.56530924
116Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.56048663
117Endocytosis_Homo sapiens_hsa041440.54882053
118Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.54067364
119Melanoma_Homo sapiens_hsa052180.53363731
120Histidine metabolism_Homo sapiens_hsa003400.52966429
121Notch signaling pathway_Homo sapiens_hsa043300.52894342
122Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.51572158
123Thyroid cancer_Homo sapiens_hsa052160.51076373
124Fatty acid degradation_Homo sapiens_hsa000710.50027750
125One carbon pool by folate_Homo sapiens_hsa006700.49744173
126Phenylalanine metabolism_Homo sapiens_hsa003600.49721073
127Dilated cardiomyopathy_Homo sapiens_hsa054140.49348540
128Ras signaling pathway_Homo sapiens_hsa040140.48519603
129Sphingolipid metabolism_Homo sapiens_hsa006000.48427448
130Starch and sucrose metabolism_Homo sapiens_hsa005000.48331568
131Pathways in cancer_Homo sapiens_hsa052000.47878183
132Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.47878121
133Morphine addiction_Homo sapiens_hsa050320.47668776
134Lysine degradation_Homo sapiens_hsa003100.47348750
135Endometrial cancer_Homo sapiens_hsa052130.47246249
136Tyrosine metabolism_Homo sapiens_hsa003500.46811080
137Ether lipid metabolism_Homo sapiens_hsa005650.45846194
138Adherens junction_Homo sapiens_hsa045200.42194887
139Renin-angiotensin system_Homo sapiens_hsa046140.39826291
140Synaptic vesicle cycle_Homo sapiens_hsa047210.38117350
141Primary bile acid biosynthesis_Homo sapiens_hsa001200.37539344
142Nitrogen metabolism_Homo sapiens_hsa009100.37410137
143Retinol metabolism_Homo sapiens_hsa008300.36373831
144Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.36087409
145Basal cell carcinoma_Homo sapiens_hsa052170.35749364
146Chemical carcinogenesis_Homo sapiens_hsa052040.33678750
147Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.30295643

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