TCP10L2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pattern specification involved in kidney development (GO:0061004)5.87985400
2regulation of T-helper 2 cell differentiation (GO:0045628)5.70993502
3regulation of T-helper 1 cell differentiation (GO:0045625)5.51652912
4negative regulation of sodium ion transport (GO:0010766)4.84252842
5negative regulation of T-helper cell differentiation (GO:0045623)4.71524204
6negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)4.71524204
7positive regulation of T cell cytokine production (GO:0002726)4.66617623
8indole-containing compound catabolic process (GO:0042436)4.65702414
9indolalkylamine catabolic process (GO:0046218)4.65702414
10tryptophan catabolic process (GO:0006569)4.65702414
11fusion of sperm to egg plasma membrane (GO:0007342)4.52328120
12kynurenine metabolic process (GO:0070189)4.45727825
13negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)4.28444915
14sperm motility (GO:0030317)4.22741139
15cellular response to exogenous dsRNA (GO:0071360)4.07661917
16trivalent inorganic anion homeostasis (GO:0072506)4.02294004
17phosphate ion homeostasis (GO:0055062)4.02294004
18oligosaccharide catabolic process (GO:0009313)3.91728702
19response to pheromone (GO:0019236)3.91014942
20regulation of memory T cell differentiation (GO:0043380)3.88443979
21positive regulation of type 2 immune response (GO:0002830)3.84572969
22cilium or flagellum-dependent cell motility (GO:0001539)3.76582494
23cellular anion homeostasis (GO:0030002)3.76547731
24negative regulation of alpha-beta T cell differentiation (GO:0046639)3.75628270
25intestinal cholesterol absorption (GO:0030299)3.70814519
26regulation of regulatory T cell differentiation (GO:0045589)3.68572350
27natural killer cell activation involved in immune response (GO:0002323)3.67976075
28positive regulation of T-helper cell differentiation (GO:0045624)3.63479288
29aromatic amino acid family catabolic process (GO:0009074)3.57891213
30sulfation (GO:0051923)3.50558038
31positive regulation of fatty acid beta-oxidation (GO:0032000)3.50496206
32tryptophan metabolic process (GO:0006568)3.49807392
33negative regulation of fibrinolysis (GO:0051918)3.37433312
34plasma membrane fusion (GO:0045026)3.37432671
35low-density lipoprotein particle remodeling (GO:0034374)3.34662496
36regulation of T cell cytokine production (GO:0002724)3.32820451
37epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.31669561
38negative regulation of alpha-beta T cell activation (GO:0046636)3.31000120
39axonemal dynein complex assembly (GO:0070286)3.30467458
40peroxisome fission (GO:0016559)3.27154884
41membrane protein intracellular domain proteolysis (GO:0031293)3.24825170
42protein-lipid complex remodeling (GO:0034368)3.14564664
43macromolecular complex remodeling (GO:0034367)3.14564664
44plasma lipoprotein particle remodeling (GO:0034369)3.14564664
45spermatid development (GO:0007286)3.13670468
46regulation of somitogenesis (GO:0014807)3.12035421
47acrosome assembly (GO:0001675)3.10898805
48cellular response to prostaglandin stimulus (GO:0071379)3.07672116
49regulation of T-helper 1 type immune response (GO:0002825)3.06076906
50glomerular basement membrane development (GO:0032836)3.00580926
51regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.98172778
52triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.95118247
53regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)2.94740756
54positive regulation of endothelial cell differentiation (GO:0045603)2.91424443
55negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)2.89851068
56regulation of interleukin-13 production (GO:0032656)2.89285881
57cell proliferation involved in metanephros development (GO:0072203)2.87231199
58high-density lipoprotein particle remodeling (GO:0034375)2.86571317
59adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.86258019
60gamma-aminobutyric acid transport (GO:0015812)2.85627401
61cellular zinc ion homeostasis (GO:0006882)2.85270602
62indole-containing compound metabolic process (GO:0042430)2.84317121
63regulation of fibrinolysis (GO:0051917)2.83707212
64regulation of cytokine secretion involved in immune response (GO:0002739)2.83593149
65positive regulation of lipid catabolic process (GO:0050996)2.81569196
66primary amino compound metabolic process (GO:1901160)2.80066690
67regulation of cilium movement (GO:0003352)2.78367918
68blood coagulation, intrinsic pathway (GO:0007597)2.78290673
69indolalkylamine metabolic process (GO:0006586)2.77314756
70regulation of T-helper cell differentiation (GO:0045622)2.76985018
71nephron epithelium morphogenesis (GO:0072088)2.76852827
72nephron tubule morphogenesis (GO:0072078)2.76852827
73acrosome reaction (GO:0007340)2.75511116
74negative regulation of telomere maintenance (GO:0032205)2.74878750
75reverse cholesterol transport (GO:0043691)2.71974919
76peristalsis (GO:0030432)2.71792283
77response to prostaglandin (GO:0034694)2.71516844
78negative regulation of astrocyte differentiation (GO:0048712)2.70296150
79negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.69645473
80neuronal action potential (GO:0019228)2.68633218
81sperm capacitation (GO:0048240)2.68007505
82modified amino acid transport (GO:0072337)2.67142982
83cellular biogenic amine catabolic process (GO:0042402)2.64812725
84amine catabolic process (GO:0009310)2.64812725
852-oxoglutarate metabolic process (GO:0006103)2.64594114
86basic amino acid transport (GO:0015802)2.63822078
87very-low-density lipoprotein particle assembly (GO:0034379)2.62745351
88peptidyl-threonine dephosphorylation (GO:0035970)2.62714154
89cholesterol efflux (GO:0033344)2.62092694
90negative regulation of sterol transport (GO:0032372)2.62026636
91negative regulation of cholesterol transport (GO:0032375)2.62026636
92sperm-egg recognition (GO:0035036)2.61760667
933-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.61734783
94purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.61734783
95serotonin metabolic process (GO:0042428)2.61462077
96negative regulation of T cell differentiation (GO:0045581)2.59205529
97sleep (GO:0030431)2.57636659
98positive regulation of T cell mediated immunity (GO:0002711)2.57273121
99negative regulation of insulin receptor signaling pathway (GO:0046627)2.56552062
100multicellular organism reproduction (GO:0032504)2.56379942

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.75212057
2EZH2_22144423_ChIP-Seq_EOC_Human2.87012245
3VDR_22108803_ChIP-Seq_LS180_Human2.69712458
4GBX2_23144817_ChIP-Seq_PC3_Human2.55505467
5ZNF274_21170338_ChIP-Seq_K562_Hela2.39606695
6TCF4_18268006_ChIP-ChIP_LS174T_Human2.27013263
7AR_21572438_ChIP-Seq_LNCaP_Human2.20377856
8EGR1_23403033_ChIP-Seq_LIVER_Mouse2.14261397
9HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.03215382
10TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.92559075
11POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.92559075
12PCGF2_27294783_Chip-Seq_ESCs_Mouse1.76359851
13CBX2_27304074_Chip-Seq_ESCs_Mouse1.73943741
14CTBP2_25329375_ChIP-Seq_LNCAP_Human1.73219640
15CTBP1_25329375_ChIP-Seq_LNCAP_Human1.64632278
16EED_16625203_ChIP-ChIP_MESCs_Mouse1.64032323
17FLI1_27457419_Chip-Seq_LIVER_Mouse1.62278615
18MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.62158118
19ER_23166858_ChIP-Seq_MCF-7_Human1.57319131
20ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.56147750
21FOXA2_19822575_ChIP-Seq_HepG2_Human1.53497500
22ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.52965314
23FUS_26573619_Chip-Seq_HEK293_Human1.52385884
24TAF15_26573619_Chip-Seq_HEK293_Human1.47525594
25ZFP57_27257070_Chip-Seq_ESCs_Mouse1.46049843
26SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.42552256
27CBP_20019798_ChIP-Seq_JUKART_Human1.42481005
28IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.42481005
29BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.39150991
30SUZ12_27294783_Chip-Seq_ESCs_Mouse1.36455086
31GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.35262133
32RUNX2_22187159_ChIP-Seq_PCA_Human1.33887554
33P300_19829295_ChIP-Seq_ESCs_Human1.33502228
34NR3C1_21868756_ChIP-Seq_MCF10A_Human1.33490964
35DROSHA_22980978_ChIP-Seq_HELA_Human1.33135314
36TDRD3_21172665_ChIP-Seq_MCF-7_Human1.32596111
37SMAD3_21741376_ChIP-Seq_EPCs_Human1.30061463
38REST_21632747_ChIP-Seq_MESCs_Mouse1.28003144
39PIAS1_25552417_ChIP-Seq_VCAP_Human1.25932268
40PCGF2_27294783_Chip-Seq_NPCs_Mouse1.25635609
41RNF2_27304074_Chip-Seq_NSC_Mouse1.24387579
42UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.24237061
43BMI1_23680149_ChIP-Seq_NPCS_Mouse1.21657389
44EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.21019562
45JARID2_20075857_ChIP-Seq_MESCs_Mouse1.20675660
46PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.19880154
47GATA3_21878914_ChIP-Seq_MCF-7_Human1.19783123
48SMAD4_21741376_ChIP-Seq_EPCs_Human1.19559684
49CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.17956861
50FOXA1_21572438_ChIP-Seq_LNCaP_Human1.17230252
51ARNT_22903824_ChIP-Seq_MCF-7_Human1.16995082
52CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.16969158
53SUZ12_27294783_Chip-Seq_NPCs_Mouse1.16729384
54SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.16723457
55VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.16234234
56AR_25329375_ChIP-Seq_VCAP_Human1.16074192
57RXR_22108803_ChIP-Seq_LS180_Human1.15848713
58FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.13390125
59FOXH1_21741376_ChIP-Seq_EPCs_Human1.13241241
60BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.13059513
61TAF2_19829295_ChIP-Seq_ESCs_Human1.12256032
62LXR_22158963_ChIP-Seq_LIVER_Mouse1.10837003
63FOXA1_27270436_Chip-Seq_PROSTATE_Human1.10393997
64FOXA1_25329375_ChIP-Seq_VCAP_Human1.10393997
65SMAD4_21741376_ChIP-Seq_HESCs_Human1.09851775
66RAC3_21632823_ChIP-Seq_H3396_Human1.08424437
67POU3F2_20337985_ChIP-ChIP_501MEL_Human1.06780646
68NANOG_20526341_ChIP-Seq_ESCs_Human1.06055081
69EZH2_27294783_Chip-Seq_ESCs_Mouse1.05518020
70AR_20517297_ChIP-Seq_VCAP_Human1.05486518
71NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.04408750
72EZH2_18974828_ChIP-Seq_MESCs_Mouse1.04386908
73RNF2_18974828_ChIP-Seq_MESCs_Mouse1.04386908
74NFE2_27457419_Chip-Seq_LIVER_Mouse1.03525875
75TOP2B_26459242_ChIP-Seq_MCF-7_Human1.03130991
76STAT3_23295773_ChIP-Seq_U87_Human1.02739195
77JARID2_20064375_ChIP-Seq_MESCs_Mouse1.01166086
78CEBPB_22108803_ChIP-Seq_LS180_Human1.00876371
79SMAD4_21799915_ChIP-Seq_A2780_Human1.00376391
80NOTCH1_21737748_ChIP-Seq_TLL_Human1.00088686
81ERA_21632823_ChIP-Seq_H3396_Human0.98393248
82TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.97606775
83TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97219884
84CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.96866401
85WDR5_24793694_ChIP-Seq_LNCAP_Human0.96704567
86EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.96554443
87NANOG_19829295_ChIP-Seq_ESCs_Human0.95882719
88SOX2_19829295_ChIP-Seq_ESCs_Human0.95882719
89FOXH1_21741376_ChIP-Seq_ESCs_Human0.95598479
90EZH2_27304074_Chip-Seq_ESCs_Mouse0.95586763
91TP53_18474530_ChIP-ChIP_U2OS_Human0.95140975
92STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.95106511
93MYC_19829295_ChIP-Seq_ESCs_Human0.94282398
94CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.94246003
95SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.93867848
96RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.93741869
97NANOG_18555785_Chip-Seq_ESCs_Mouse0.93446454
98SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.93014010
99RUNX_20019798_ChIP-Seq_JUKART_Human0.92953571
100AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.92405743

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization4.40429623
2MP0002736_abnormal_nociception_after3.35683331
3MP0000569_abnormal_digit_pigmentation3.35107039
4MP0002139_abnormal_hepatobiliary_system3.13952492
5MP0003195_calcinosis3.11242503
6MP0002254_reproductive_system_inflammat3.02392938
7MP0003878_abnormal_ear_physiology3.01799275
8MP0005377_hearing/vestibular/ear_phenot3.01799275
9MP0005645_abnormal_hypothalamus_physiol3.01296663
10MP0001968_abnormal_touch/_nociception2.97663339
11MP0008875_abnormal_xenobiotic_pharmacok2.61853219
12MP0000566_synostosis2.54677365
13MP0005085_abnormal_gallbladder_physiolo2.51395738
14MP0003136_yellow_coat_color2.47243097
15MP0005365_abnormal_bile_salt2.42539149
16MP0010329_abnormal_lipoprotein_level2.26953461
17MP0005360_urolithiasis2.20723219
18MP0002735_abnormal_chemical_nociception2.17081485
19MP0004043_abnormal_pH_regulation2.10611546
20MP0004885_abnormal_endolymph2.08694585
21MP0001666_abnormal_nutrient_absorption1.94078015
22MP0005167_abnormal_blood-brain_barrier1.90422735
23MP0004742_abnormal_vestibular_system1.89165450
24MP0005423_abnormal_somatic_nervous1.87686461
25MP0002653_abnormal_ependyma_morphology1.81152528
26MP0001346_abnormal_lacrimal_gland1.77418354
27MP0003252_abnormal_bile_duct1.74406383
28MP0003646_muscle_fatigue1.70023253
29MP0003698_abnormal_male_reproductive1.69941527
30MP0003879_abnormal_hair_cell1.63547664
31MP0005671_abnormal_response_to1.62356520
32MP0002822_catalepsy1.57129492
33MP0001905_abnormal_dopamine_level1.44535492
34MP0005670_abnormal_white_adipose1.43815167
35MP0005332_abnormal_amino_acid1.42594105
36MP0001348_abnormal_lacrimal_gland1.42125849
37MP0003941_abnormal_skin_development1.39305161
38MP0001485_abnormal_pinna_reflex1.39056558
39MP0003638_abnormal_response/metabolism_1.37172397
40MP0003868_abnormal_feces_composition1.37000448
41MP0001929_abnormal_gametogenesis1.32223083
42MP0005187_abnormal_penis_morphology1.31389791
43MP0008872_abnormal_physiological_respon1.27388743
44MP0003122_maternal_imprinting1.22006776
45MP0002733_abnormal_thermal_nociception1.21363445
46MP0005058_abnormal_lysosome_morphology1.20510720
47MP0003315_abnormal_perineum_morphology1.19284565
48MP0002067_abnormal_sensory_capabilities1.18124181
49MP0009745_abnormal_behavioral_response1.17744667
50MP0000534_abnormal_ureter_morphology1.17170306
51MP0001765_abnormal_ion_homeostasis1.14151328
52MP0002118_abnormal_lipid_homeostasis1.13907433
53MP0001501_abnormal_sleep_pattern1.10074472
54MP0002160_abnormal_reproductive_system1.08895936
55MP0001873_stomach_inflammation1.04605313
56MP0009785_altered_susceptibility_to1.04433808
57MP0002138_abnormal_hepatobiliary_system1.04143885
58MP0009046_muscle_twitch1.03578908
59MP0003329_amyloid_beta_deposits1.02691693
60MP0002161_abnormal_fertility/fecundity1.02548369
61MP0001486_abnormal_startle_reflex0.99462134
62MP0002272_abnormal_nervous_system0.97686540
63MP0003303_peritoneal_inflammation0.97366632
64MP0005083_abnormal_biliary_tract0.92779986
65MP0004142_abnormal_muscle_tone0.91313255
66MP0006292_abnormal_olfactory_placode0.91291609
67MP0005448_abnormal_energy_balance0.91283065
68MP0002638_abnormal_pupillary_reflex0.88386924
69MP0009384_cardiac_valve_regurgitation0.87783645
70MP0002557_abnormal_social/conspecific_i0.86652973
71MP0005310_abnormal_salivary_gland0.83416037
72MP0000639_abnormal_adrenal_gland0.82905532
73MP0000427_abnormal_hair_cycle0.82460085
74MP0002938_white_spotting0.79755529
75MP0003633_abnormal_nervous_system0.79421362
76MP0002229_neurodegeneration0.78597712
77MP0002572_abnormal_emotion/affect_behav0.77994083
78MP0002064_seizures0.77250015
79MP0005551_abnormal_eye_electrophysiolog0.75978816
80MP0000026_abnormal_inner_ear0.75889933
81MP0005636_abnormal_mineral_homeostasis0.75741782
82MP0001970_abnormal_pain_threshold0.74476405
83MP0000631_abnormal_neuroendocrine_gland0.73615389
84MP0008569_lethality_at_weaning0.73230748
85MP0001963_abnormal_hearing_physiology0.70893935
86MP0009643_abnormal_urine_homeostasis0.70567517
87MP0009840_abnormal_foam_cell0.69835147
88MP0009278_abnormal_bone_marrow0.69613301
89MP0000604_amyloidosis0.68985185
90MP0000230_abnormal_systemic_arterial0.68815240
91MP0005379_endocrine/exocrine_gland_phen0.68723142
92MP0005389_reproductive_system_phenotype0.68036409
93MP0003631_nervous_system_phenotype0.67695578
94MP0008995_early_reproductive_senescence0.66125773
95MP0001664_abnormal_digestion0.65676901
96MP0002148_abnormal_hypersensitivity_rea0.65114505
97MP0002876_abnormal_thyroid_physiology0.64453996
98MP0000609_abnormal_liver_physiology0.61958271
99MP0002210_abnormal_sex_determination0.60873183
100MP0005084_abnormal_gallbladder_morpholo0.59387560

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)4.30718302
2Enlarged epiphyses (HP:0010580)4.01741985
3Potter facies (HP:0002009)3.91789625
4Facial shape deformation (HP:0011334)3.91789625
5Dynein arm defect of respiratory motile cilia (HP:0012255)3.89574520
6Absent/shortened dynein arms (HP:0200106)3.89574520
7Prolonged partial thromboplastin time (HP:0003645)3.81729696
8Glomerulonephritis (HP:0000099)3.72691085
9Aplasia/Hypoplasia of the pubic bone (HP:0009104)3.45370545
10Nephritis (HP:0000123)3.36430748
11Conical tooth (HP:0000698)3.11794705
12Osteomalacia (HP:0002749)3.08518437
13Epidermoid cyst (HP:0200040)3.04561789
14Xanthomatosis (HP:0000991)2.93574631
15Hyperphosphaturia (HP:0003109)2.91416911
16Hypobetalipoproteinemia (HP:0003563)2.85114923
17Abnormal respiratory motile cilium morphology (HP:0005938)2.71945898
18Abnormal respiratory epithelium morphology (HP:0012253)2.71945898
19Progressive cerebellar ataxia (HP:0002073)2.67006460
20Spastic tetraparesis (HP:0001285)2.57213663
21Supernumerary bones of the axial skeleton (HP:0009144)2.46337912
22Abnormal urine phosphate concentration (HP:0012599)2.45272448
23Vascular calcification (HP:0004934)2.44237238
24Hypophosphatemic rickets (HP:0004912)2.42070181
25Midline defect of the nose (HP:0004122)2.41488779
26Tubulointerstitial abnormality (HP:0001969)2.38574637
27Tubulointerstitial fibrosis (HP:0005576)2.34912592
28Complement deficiency (HP:0004431)2.33901081
29Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.33313787
30Supernumerary spleens (HP:0009799)2.31731052
31Joint hemorrhage (HP:0005261)2.31408985
32Spontaneous abortion (HP:0005268)2.27485143
33Attenuation of retinal blood vessels (HP:0007843)2.26797297
34Metabolic alkalosis (HP:0200114)2.24006235
35Abnormal urine output (HP:0012590)2.22231789
36Hypoplastic ischia (HP:0003175)2.21301469
37Delayed CNS myelination (HP:0002188)2.20961500
38Stage 5 chronic kidney disease (HP:0003774)2.18981191
39Abnormality of the pubic bones (HP:0003172)2.18276052
40Tongue fasciculations (HP:0001308)2.17374860
41Abnormal ciliary motility (HP:0012262)2.17221528
42Trigonocephaly (HP:0000243)2.16699303
43Agitation (HP:0000713)2.14653504
44Tubular atrophy (HP:0000092)2.14082785
45Pancreatic cysts (HP:0001737)2.13547105
46Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.12414251
47Progressive hearing impairment (HP:0001730)2.09819217
48Gingival bleeding (HP:0000225)2.06430045
49Neoplasm of the heart (HP:0100544)2.06339310
50Muscle fibrillation (HP:0010546)1.99737246
51Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.99364650
52Abnormality of alanine metabolism (HP:0010916)1.99364650
53Hyperalaninemia (HP:0003348)1.99364650
54Cardiovascular calcification (HP:0011915)1.98580860
55Hypokalemic alkalosis (HP:0001949)1.97507413
56Back pain (HP:0003418)1.96586099
57Tubulointerstitial nephritis (HP:0001970)1.96270711
58Optic neuritis (HP:0100653)1.95758654
59Retrobulbar optic neuritis (HP:0100654)1.95758654
60Hypercholesterolemia (HP:0003124)1.93993426
61Anomalous pulmonary venous return (HP:0010772)1.92579522
62Genetic anticipation (HP:0003743)1.92340564
63Abnormality of aromatic amino acid family metabolism (HP:0004338)1.89548027
64Keratoconjunctivitis (HP:0001096)1.87441465
65Tinnitus (HP:0000360)1.86710418
66Proximal tubulopathy (HP:0000114)1.85661678
67Nephronophthisis (HP:0000090)1.85520635
68Focal segmental glomerulosclerosis (HP:0000097)1.85262219
69Abnormality of renal excretion (HP:0011036)1.84203365
70Supernumerary ribs (HP:0005815)1.81269300
71Increased IgE level (HP:0003212)1.79044309
72True hermaphroditism (HP:0010459)1.78628579
73Arthropathy (HP:0003040)1.76984613
74Abnormality of the ischium (HP:0003174)1.76773247
75Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.76529965
76Broad palm (HP:0001169)1.76454635
77Abnormality of macular pigmentation (HP:0008002)1.76156113
78Amyloidosis (HP:0011034)1.75024816
79Abnormality of the renal cortex (HP:0011035)1.74666609
80Renovascular hypertension (HP:0100817)1.74250045
81Aplasia/Hypoplasia of the tibia (HP:0005772)1.74083787
82Glycosuria (HP:0003076)1.74029780
83Abnormality of urine glucose concentration (HP:0011016)1.74029780
84Widely patent fontanelles and sutures (HP:0004492)1.73991775
85Abnormality of cochlea (HP:0000375)1.72859196
86Abnormality of the renal medulla (HP:0100957)1.72603828
87Acanthocytosis (HP:0001927)1.71829725
88Prominent supraorbital ridges (HP:0000336)1.71754058
89Increased neuronal autofluorescent lipopigment (HP:0002074)1.71340252
90Glomerulosclerosis (HP:0000096)1.71233415
91Opisthotonus (HP:0002179)1.71187931
92Hemiplegia (HP:0002301)1.70764384
93Abnormal respiratory motile cilium physiology (HP:0012261)1.69990152
94Abnormality of proline metabolism (HP:0010907)1.67575267
95Hydroxyprolinuria (HP:0003080)1.67575267
96Hyperlipoproteinemia (HP:0010980)1.67357823
97Congenital stationary night blindness (HP:0007642)1.65426732
98Morphological abnormality of the pyramidal tract (HP:0002062)1.63666720
99Abnormality of the sella turcica (HP:0002679)1.63047859
100Restlessness (HP:0000711)1.62756358

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK2.77571094
2RIPK42.42973798
3PNCK2.17082298
4TLK12.14955531
5MAP4K213.6793015
6MAPK151.92439329
7TXK1.65578893
8ACVR1B1.62062935
9GRK61.53699382
10BCKDK1.47003946
11TYRO31.40400554
12WNK41.29626767
13BMPR1B1.27901538
14OXSR11.27424689
15DDR21.23313454
16ICK1.21314709
17CAMK1D1.12166569
18MAP3K111.04783632
19STK391.03547378
20ADRBK21.03295253
21CAMK1G1.00288859
22PLK40.99409371
23CDK30.92715476
24IRAK10.92119188
25CAMKK20.90708504
26FGFR30.89601731
27EPHA30.88124128
28TAOK30.87656251
29MAP3K40.85495980
30ZAK0.81010709
31YES10.78640520
32PDK10.73168559
33MAPK130.72025762
34FGFR40.71264511
35CDK190.68858443
36INSRR0.65580009
37TBK10.65545252
38MATK0.62316200
39CDK80.60286581
40PRKCG0.59093420
41PRKCQ0.58236897
42STK38L0.57712841
43CSNK1A1L0.57260268
44KIT0.56613201
45CSNK1G20.56557097
46PDPK10.56299888
47CSK0.55835367
48TAOK20.55307911
49PRKCZ0.51556026
50CSNK1G30.50608310
51GRK70.50253075
52STK380.49443130
53CAMK10.47069525
54PDGFRB0.46506617
55CSNK1G10.46333501
56IKBKB0.44661807
57TAOK10.41804741
58MAP3K30.40904653
59ITK0.39974248
60DYRK1B0.36911291
61MAP3K140.36601103
62SYK0.36497887
63CAMK40.36406448
64PKN10.35327556
65FGFR10.34201495
66MAP3K70.33867950
67IKBKE0.31734701
68IRAK20.29593621
69PIM20.29377764
70CHUK0.29030520
71LYN0.28828789
72CDK70.28778500
73UHMK10.24320933
74NTRK20.22857342
75GRK10.20629799
76IGF1R0.19723043
77AKT30.19142799
78CDK120.18889679
79WEE10.18845431
80JAK30.18552958
81TEC0.18451505
82CAMK2A0.18340361
83SGK10.18267968
84PLK20.17622494
85ERBB20.17599423
86PRKACB0.17334421
87INSR0.17243272
88PRKACA0.17194606
89IRAK40.16973321
90MAP4K10.16853754
91MAPK110.16643714
92LCK0.16589821
93RPS6KA30.15699257
94TGFBR20.15029769
95CSNK1D0.14617692
96CAMK2B0.14313300
97PRKG10.14292224
98RET0.13449892
99ADRBK10.13120403
100PIK3CA0.13009436

Predicted pathways (KEGG)

RankGene SetZ-score
1Fatty acid biosynthesis_Homo sapiens_hsa000612.77808802
2Complement and coagulation cascades_Homo sapiens_hsa046102.63451640
3Cyanoamino acid metabolism_Homo sapiens_hsa004602.61599515
4Caffeine metabolism_Homo sapiens_hsa002322.44780911
5ABC transporters_Homo sapiens_hsa020102.43029873
6Butanoate metabolism_Homo sapiens_hsa006502.24722769
7Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.22854532
8Fat digestion and absorption_Homo sapiens_hsa049752.08526829
9Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.03244470
10alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.99997065
11Nitrogen metabolism_Homo sapiens_hsa009101.96204801
12Maturity onset diabetes of the young_Homo sapiens_hsa049501.91163675
13Linoleic acid metabolism_Homo sapiens_hsa005911.89634347
14Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.82856950
15Sulfur relay system_Homo sapiens_hsa041221.79651742
16Glycerolipid metabolism_Homo sapiens_hsa005611.74089863
17Tryptophan metabolism_Homo sapiens_hsa003801.72875330
18Steroid biosynthesis_Homo sapiens_hsa001001.72357655
19Sulfur metabolism_Homo sapiens_hsa009201.66123233
20Renin-angiotensin system_Homo sapiens_hsa046141.65240802
21Retinol metabolism_Homo sapiens_hsa008301.62078691
22Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.61373327
23Vitamin digestion and absorption_Homo sapiens_hsa049771.56975382
24Steroid hormone biosynthesis_Homo sapiens_hsa001401.45673293
25PPAR signaling pathway_Homo sapiens_hsa033201.43679544
26Peroxisome_Homo sapiens_hsa041461.43290753
27Nicotine addiction_Homo sapiens_hsa050331.43220333
28Chemical carcinogenesis_Homo sapiens_hsa052041.40990194
29Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.38552599
30Taste transduction_Homo sapiens_hsa047421.29214537
31Bile secretion_Homo sapiens_hsa049761.28296192
32Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.26621256
33Histidine metabolism_Homo sapiens_hsa003401.25223541
34Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.23977284
35Salivary secretion_Homo sapiens_hsa049701.23123050
36Olfactory transduction_Homo sapiens_hsa047401.22135029
37Graft-versus-host disease_Homo sapiens_hsa053321.21561124
38Staphylococcus aureus infection_Homo sapiens_hsa051501.21368613
39Allograft rejection_Homo sapiens_hsa053301.19644332
40Fatty acid degradation_Homo sapiens_hsa000711.15867954
41Pentose and glucuronate interconversions_Homo sapiens_hsa000401.14121054
42Systemic lupus erythematosus_Homo sapiens_hsa053221.13179997
43Phototransduction_Homo sapiens_hsa047441.08183916
44RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.07204737
45Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.06925540
46African trypanosomiasis_Homo sapiens_hsa051431.06044157
47Fatty acid metabolism_Homo sapiens_hsa012121.04189768
48Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.03562308
49Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.01692868
50NF-kappa B signaling pathway_Homo sapiens_hsa040640.98329705
51Malaria_Homo sapiens_hsa051440.95971703
52Ether lipid metabolism_Homo sapiens_hsa005650.92049556
53Cardiac muscle contraction_Homo sapiens_hsa042600.91133821
54Drug metabolism - other enzymes_Homo sapiens_hsa009830.87195728
55Adipocytokine signaling pathway_Homo sapiens_hsa049200.86058151
56Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.85616315
57Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.83895829
58Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.80821773
59Autoimmune thyroid disease_Homo sapiens_hsa053200.80696337
60Type I diabetes mellitus_Homo sapiens_hsa049400.79209797
61Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.79200176
62Primary bile acid biosynthesis_Homo sapiens_hsa001200.79163424
63Intestinal immune network for IgA production_Homo sapiens_hsa046720.79048417
64Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.77219971
65NOD-like receptor signaling pathway_Homo sapiens_hsa046210.73775077
66Ovarian steroidogenesis_Homo sapiens_hsa049130.71845845
67Protein digestion and absorption_Homo sapiens_hsa049740.70949586
68Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.69143534
69Glycerophospholipid metabolism_Homo sapiens_hsa005640.67631320
70Glutamatergic synapse_Homo sapiens_hsa047240.67366969
71Phenylalanine metabolism_Homo sapiens_hsa003600.66695764
72Type II diabetes mellitus_Homo sapiens_hsa049300.65052191
73Arachidonic acid metabolism_Homo sapiens_hsa005900.64658478
74Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.61934950
75Asthma_Homo sapiens_hsa053100.60447197
76Starch and sucrose metabolism_Homo sapiens_hsa005000.55680776
77Vascular smooth muscle contraction_Homo sapiens_hsa042700.55459588
78Morphine addiction_Homo sapiens_hsa050320.54616567
79Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.53832588
80Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.53327491
81Jak-STAT signaling pathway_Homo sapiens_hsa046300.51298100
82Renin secretion_Homo sapiens_hsa049240.51287874
83Propanoate metabolism_Homo sapiens_hsa006400.50138876
84Insulin resistance_Homo sapiens_hsa049310.49763400
85Dorso-ventral axis formation_Homo sapiens_hsa043200.47027249
86GABAergic synapse_Homo sapiens_hsa047270.46439617
87Primary immunodeficiency_Homo sapiens_hsa053400.43094515
88cAMP signaling pathway_Homo sapiens_hsa040240.42850331
89Other glycan degradation_Homo sapiens_hsa005110.41105490
90beta-Alanine metabolism_Homo sapiens_hsa004100.40602226
91Tyrosine metabolism_Homo sapiens_hsa003500.39175789
92Arginine and proline metabolism_Homo sapiens_hsa003300.38487341
93Glycosaminoglycan degradation_Homo sapiens_hsa005310.36603842
94Arginine biosynthesis_Homo sapiens_hsa002200.35198810
95TNF signaling pathway_Homo sapiens_hsa046680.33005890
96Toll-like receptor signaling pathway_Homo sapiens_hsa046200.32752492
97Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.32142929
98Antigen processing and presentation_Homo sapiens_hsa046120.30886268
99Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.30403692
100Circadian entrainment_Homo sapiens_hsa047130.30108026

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