TCP10L

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pyrimidine nucleobase catabolic process (GO:0006208)6.26825887
2substrate-independent telencephalic tangential interneuron migration (GO:0021843)5.28327579
3substrate-independent telencephalic tangential migration (GO:0021826)5.28327579
4neuronal ion channel clustering (GO:0045161)5.16183443
5sperm motility (GO:0030317)5.07196007
6protein polyglutamylation (GO:0018095)4.96997047
7behavioral response to nicotine (GO:0035095)4.86955973
8nucleobase catabolic process (GO:0046113)4.82066688
9acrosome reaction (GO:0007340)4.75276369
10regulation of cilium movement (GO:0003352)4.47590482
11neurofilament cytoskeleton organization (GO:0060052)4.34117204
12cranial nerve morphogenesis (GO:0021602)4.21273039
13response to pheromone (GO:0019236)4.09916075
14transmission of nerve impulse (GO:0019226)4.07945500
15neuron recognition (GO:0008038)4.05805290
16peristalsis (GO:0030432)4.04919594
17positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.98601071
18regulation of synapse structural plasticity (GO:0051823)3.87027213
19presynaptic membrane organization (GO:0097090)3.82871800
20calcium ion-dependent exocytosis (GO:0017156)3.77661344
21establishment of mitochondrion localization (GO:0051654)3.75428542
22urogenital system development (GO:0001655)3.74427700
23single strand break repair (GO:0000012)3.68618490
24forebrain neuron differentiation (GO:0021879)3.67053957
25microtubule severing (GO:0051013)3.66432858
26synaptic transmission, dopaminergic (GO:0001963)3.64578059
27cell migration in hindbrain (GO:0021535)3.60596101
28negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.59911019
29regulation of microtubule-based movement (GO:0060632)3.57337047
30axonal fasciculation (GO:0007413)3.54794824
31locomotory exploration behavior (GO:0035641)3.52274140
32positive regulation of growth hormone secretion (GO:0060124)3.46801179
33establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.38399064
34mitochondrion transport along microtubule (GO:0047497)3.38399064
35neurotransmitter-gated ion channel clustering (GO:0072578)3.32893712
36response to acidic pH (GO:0010447)3.28677331
37brain morphogenesis (GO:0048854)3.24950220
38phenylpropanoid metabolic process (GO:0009698)3.24826708
39negative regulation of catecholamine secretion (GO:0033604)3.21268575
40neuromuscular synaptic transmission (GO:0007274)3.08070978
41axonemal dynein complex assembly (GO:0070286)3.04558544
42microtubule depolymerization (GO:0007019)3.01986735
43cellular ketone body metabolic process (GO:0046950)3.00147914
44epithelial cilium movement (GO:0003351)2.99736285
45neural tube formation (GO:0001841)2.97492110
46glucocorticoid biosynthetic process (GO:0006704)2.97309673
47sperm-egg recognition (GO:0035036)2.94287955
48pattern specification involved in kidney development (GO:0061004)2.93839480
49spermatid development (GO:0007286)2.93375757
50regulation of neuron migration (GO:2001222)2.91726109
51spinal cord association neuron differentiation (GO:0021527)2.91335689
52neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.88586833
53protein targeting to Golgi (GO:0000042)2.87884039
54cerebral cortex radially oriented cell migration (GO:0021799)2.87433223
55cranial nerve structural organization (GO:0021604)2.86341049
56regulation of dopamine secretion (GO:0014059)2.84815141
57spermatid nucleus differentiation (GO:0007289)2.84808956
58glutamate secretion (GO:0014047)2.84402916
59protein localization to synapse (GO:0035418)2.84180097
60microtubule bundle formation (GO:0001578)2.82385085
61multicellular organism reproduction (GO:0032504)2.82354867
62synapse assembly (GO:0007416)2.81948715
63cellular response to pH (GO:0071467)2.77992444
64positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.75202277
65retinal ganglion cell axon guidance (GO:0031290)2.74807516
66establishment of protein localization to Golgi (GO:0072600)2.74687945
67cerebellar Purkinje cell differentiation (GO:0021702)2.74013433
68postsynaptic membrane organization (GO:0001941)2.73370034
69response to muscle activity (GO:0014850)2.72848894
70prepulse inhibition (GO:0060134)2.72432310
71fusion of sperm to egg plasma membrane (GO:0007342)2.72132535
72regulation of growth hormone secretion (GO:0060123)2.71230665
73metanephric mesenchyme development (GO:0072075)2.70577524
74dendritic spine morphogenesis (GO:0060997)2.69090591
75tachykinin receptor signaling pathway (GO:0007217)2.69014619
76synaptic vesicle maturation (GO:0016188)2.68028288
77cell proliferation in forebrain (GO:0021846)2.67491479
78parturition (GO:0007567)2.67334877
79sperm capacitation (GO:0048240)2.67017242
80axon ensheathment in central nervous system (GO:0032291)2.66298821
81central nervous system myelination (GO:0022010)2.66298821
82exploration behavior (GO:0035640)2.64777937
83binding of sperm to zona pellucida (GO:0007339)2.64441015
84microtubule polymerization or depolymerization (GO:0031109)2.63793978
85auditory behavior (GO:0031223)2.63538682
86C4-dicarboxylate transport (GO:0015740)2.60893847
87regulation of circadian sleep/wake cycle, sleep (GO:0045187)2.60514288
88regulation of circadian sleep/wake cycle (GO:0042749)2.60514288
89ketone body metabolic process (GO:1902224)2.60090237
90positive regulation of gastrulation (GO:2000543)2.58436494
91cranial nerve development (GO:0021545)2.58046686
92protein localization to Golgi apparatus (GO:0034067)2.57335366
93dendrite development (GO:0016358)2.56251600
94negative regulation of neurotransmitter secretion (GO:0046929)2.56035017
95cilium movement (GO:0003341)2.53213002
96mesonephros development (GO:0001823)2.52746089
97positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.52181313
98olfactory bulb development (GO:0021772)2.52152216
99establishment of monopolar cell polarity (GO:0061162)2.51851580
100establishment or maintenance of monopolar cell polarity (GO:0061339)2.51851580

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human7.35272079
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat5.33346702
3NR4A2_19515692_ChIP-ChIP_MN9D_Mouse4.78262379
4ZNF274_21170338_ChIP-Seq_K562_Hela2.87610929
5REST_21632747_ChIP-Seq_MESCs_Mouse2.66757171
6MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.43415042
7CBX2_27304074_Chip-Seq_ESCs_Mouse2.36599880
8REST_18959480_ChIP-ChIP_MESCs_Mouse2.27514318
9EZH2_27304074_Chip-Seq_ESCs_Mouse2.23654559
10SUZ12_27294783_Chip-Seq_ESCs_Mouse2.22685093
11EZH2_27294783_Chip-Seq_ESCs_Mouse2.18692304
12ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.04982231
13JARID2_20064375_ChIP-Seq_MESCs_Mouse2.04268025
14IKZF1_21737484_ChIP-ChIP_HCT116_Human2.03011228
15BMI1_23680149_ChIP-Seq_NPCS_Mouse1.99361134
16EED_16625203_ChIP-ChIP_MESCs_Mouse1.91741357
17HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.80714641
18CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.79718290
19JARID2_20075857_ChIP-Seq_MESCs_Mouse1.75907954
20* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.74959577
21CTBP2_25329375_ChIP-Seq_LNCAP_Human1.72413512
22DROSHA_22980978_ChIP-Seq_HELA_Human1.68103822
23GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.68052316
24CTCF_27219007_Chip-Seq_Bcells_Human1.65586507
25EZH2_18974828_ChIP-Seq_MESCs_Mouse1.65085933
26RNF2_18974828_ChIP-Seq_MESCs_Mouse1.65085933
27TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.63639567
28POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.63639567
29RNF2_27304074_Chip-Seq_NSC_Mouse1.59856062
30SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.58604551
31GBX2_23144817_ChIP-Seq_PC3_Human1.55027630
32IRF1_19129219_ChIP-ChIP_H3396_Human1.52469865
33RNF2_27304074_Chip-Seq_ESCs_Mouse1.51531796
34CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.50774956
35SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.50319045
36RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.44408684
37SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.42763908
38VDR_22108803_ChIP-Seq_LS180_Human1.42554307
39RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.40622951
40TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.40492008
41EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.38746454
42ERA_21632823_ChIP-Seq_H3396_Human1.37942183
43PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.37082823
44FUS_26573619_Chip-Seq_HEK293_Human1.34324929
45OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.33018975
46ETV2_25802403_ChIP-Seq_MESCs_Mouse1.31256985
47SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.29226436
48SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.27866006
49RING1B_27294783_Chip-Seq_ESCs_Mouse1.24190455
50P300_19829295_ChIP-Seq_ESCs_Human1.20773544
51CBP_20019798_ChIP-Seq_JUKART_Human1.20472569
52IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.20472569
53MTF2_20144788_ChIP-Seq_MESCs_Mouse1.15282411
54SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.13987051
55EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.11283378
56RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.11004788
57NCOR_22424771_ChIP-Seq_293T_Human1.10566683
58KLF5_20875108_ChIP-Seq_MESCs_Mouse1.07751433
59EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.07131333
60ZFP57_27257070_Chip-Seq_ESCs_Mouse1.05777226
61WDR5_24793694_ChIP-Seq_LNCAP_Human1.04545291
62GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.03099548
63SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.02670737
64RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.01615441
65UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.01092854
66* DNAJC2_21179169_ChIP-ChIP_NT2_Human1.00311997
67NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.98473885
68RARB_27405468_Chip-Seq_BRAIN_Mouse0.98250585
69GATA3_21878914_ChIP-Seq_MCF-7_Human0.98062027
70EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.97858912
71FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.97725426
72ER_23166858_ChIP-Seq_MCF-7_Human0.97418614
73RAC3_21632823_ChIP-Seq_H3396_Human0.96744903
74* OCT4_19829295_ChIP-Seq_ESCs_Human0.95760091
75NANOG_20526341_ChIP-Seq_ESCs_Human0.94409835
76YY1_22570637_ChIP-Seq_MALME-3M_Human0.93637562
77TP53_20018659_ChIP-ChIP_R1E_Mouse0.93411610
78OCT4_20526341_ChIP-Seq_ESCs_Human0.93269469
79TAF2_19829295_ChIP-Seq_ESCs_Human0.92223604
80SMAD4_21741376_ChIP-Seq_EPCs_Human0.91599894
81PHF8_20622854_ChIP-Seq_HELA_Human0.91519329
82ELF1_20517297_ChIP-Seq_JURKAT_Human0.91098090
83ERG_21242973_ChIP-ChIP_JURKAT_Human0.89410052
84E2F1_20622854_ChIP-Seq_HELA_Human0.89296269
85MYC_19829295_ChIP-Seq_ESCs_Human0.89251974
86MNX1_26342078_ChIP-Seq_MIN6-4N_Mouse0.88452824
87SMAD3_21741376_ChIP-Seq_ESCs_Human0.87154681
88* E2F1_17053090_ChIP-ChIP_MCF-7_Human0.86905009
89CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.86809195
90THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.86630864
91AR_25329375_ChIP-Seq_VCAP_Human0.86614101
92SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.84955734
93TOP2B_26459242_ChIP-Seq_MCF-7_Human0.84843555
94CTCF_20526341_ChIP-Seq_ESCs_Human0.83863319
95SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.83223059
96MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.81680524
97PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.80206613
98SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.80174965
99TP53_22573176_ChIP-Seq_HFKS_Human0.80099603
100SMAD3_21741376_ChIP-Seq_EPCs_Human0.78966376

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern5.64520562
2MP0006276_abnormal_autonomic_nervous4.63332477
3MP0002822_catalepsy3.70847716
4MP0005423_abnormal_somatic_nervous3.47903315
5MP0002653_abnormal_ependyma_morphology3.32563445
6MP0005410_abnormal_fertilization3.11184945
7MP0000778_abnormal_nervous_system2.69775814
8MP0003787_abnormal_imprinting2.53062979
9MP0001529_abnormal_vocalization2.27813092
10MP0004859_abnormal_synaptic_plasticity2.24876536
11MP0005499_abnormal_olfactory_system2.19051300
12MP0005394_taste/olfaction_phenotype2.19051300
13MP0002163_abnormal_gland_morphology2.01292275
14MP0000955_abnormal_spinal_cord1.97387154
15MP0008789_abnormal_olfactory_epithelium1.96680316
16MP0001188_hyperpigmentation1.94636146
17MP0001486_abnormal_startle_reflex1.80827060
18MP0003123_paternal_imprinting1.78387358
19MP0002272_abnormal_nervous_system1.76297572
20MP0002184_abnormal_innervation1.64593404
21MP0003635_abnormal_synaptic_transmissio1.64551663
22MP0004270_analgesia1.63470157
23MP0003011_delayed_dark_adaptation1.60810596
24MP0001984_abnormal_olfaction1.60391650
25MP0002160_abnormal_reproductive_system1.58171660
26MP0002557_abnormal_social/conspecific_i1.57492266
27MP0003646_muscle_fatigue1.50676236
28MP0003698_abnormal_male_reproductive1.50226318
29MP0002063_abnormal_learning/memory/cond1.50012572
30MP0009745_abnormal_behavioral_response1.46904250
31MP0005646_abnormal_pituitary_gland1.46277808
32MP0002572_abnormal_emotion/affect_behav1.44150943
33MP0004811_abnormal_neuron_physiology1.43954251
34MP0001968_abnormal_touch/_nociception1.41803842
35MP0006292_abnormal_olfactory_placode1.40763805
36MP0002882_abnormal_neuron_morphology1.40732378
37MP0005379_endocrine/exocrine_gland_phen1.37439648
38MP0001485_abnormal_pinna_reflex1.37115182
39MP0003315_abnormal_perineum_morphology1.33050167
40MP0003890_abnormal_embryonic-extraembry1.32552238
41MP0009046_muscle_twitch1.31234623
42MP0002752_abnormal_somatic_nervous1.29703609
43MP0002909_abnormal_adrenal_gland1.29148553
44MP0001905_abnormal_dopamine_level1.28480745
45MP0005551_abnormal_eye_electrophysiolog1.28256036
46MP0002837_dystrophic_cardiac_calcinosis1.23040650
47MP0003121_genomic_imprinting1.21499736
48MP0002067_abnormal_sensory_capabilities1.17883443
49MP0005386_behavior/neurological_phenoty1.17488837
50MP0004924_abnormal_behavior1.17488837
51MP0002734_abnormal_mechanical_nocicepti1.16163223
52MP0002733_abnormal_thermal_nociception1.15523463
53MP0005360_urolithiasis1.15446929
54MP0003879_abnormal_hair_cell1.15309342
55MP0004145_abnormal_muscle_electrophysio1.15153249
56MP0001970_abnormal_pain_threshold1.13573419
57MP0002064_seizures1.11966035
58MP0005187_abnormal_penis_morphology1.10552780
59MP0004742_abnormal_vestibular_system1.10052684
60MP0003878_abnormal_ear_physiology1.09087526
61MP0005377_hearing/vestibular/ear_phenot1.09087526
62MP0005389_reproductive_system_phenotype1.06396582
63MP0003861_abnormal_nervous_system1.06104880
64MP0001929_abnormal_gametogenesis1.05643787
65MP0002751_abnormal_autonomic_nervous1.05443163
66MP0010386_abnormal_urinary_bladder1.05334869
67MP0000534_abnormal_ureter_morphology1.04178238
68MP0002152_abnormal_brain_morphology1.01314269
69MP0001299_abnormal_eye_distance/1.00433785
70MP0002736_abnormal_nociception_after0.99885960
71MP0002735_abnormal_chemical_nociception0.97395140
72MP0002210_abnormal_sex_determination0.93559779
73MP0008995_early_reproductive_senescence0.92969575
74MP0008877_abnormal_DNA_methylation0.90406687
75MP0002229_neurodegeneration0.88911341
76MP0002638_abnormal_pupillary_reflex0.86895549
77MP0004142_abnormal_muscle_tone0.86758118
78MP0002161_abnormal_fertility/fecundity0.85811058
79MP0003122_maternal_imprinting0.82749001
80MP0001919_abnormal_reproductive_system0.81862072
81MP0001440_abnormal_grooming_behavior0.80789725
82MP0004085_abnormal_heartbeat0.80635650
83MP0004133_heterotaxia0.79614200
84MP0005195_abnormal_posterior_eye0.79365532
85MP0005645_abnormal_hypothalamus_physiol0.79140508
86MP0004134_abnormal_chest_morphology0.78191808
87MP0002066_abnormal_motor_capabilities/c0.78036131
88MP0000026_abnormal_inner_ear0.77619354
89MP0003938_abnormal_ear_development0.77013129
90MP0000631_abnormal_neuroendocrine_gland0.76157203
91MP0003942_abnormal_urinary_system0.74457301
92MP0001145_abnormal_male_reproductive0.74384291
93MP0002876_abnormal_thyroid_physiology0.73795277
94MP0004782_abnormal_surfactant_physiolog0.73478647
95MP0003718_maternal_effect0.72657021
96MP0000566_synostosis0.72422271
97MP0006072_abnormal_retinal_apoptosis0.70562292
98MP0000653_abnormal_sex_gland0.70399002
99MP0002234_abnormal_pharynx_morphology0.69374097
100MP0003119_abnormal_digestive_system0.69088201

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)4.23522119
2Oligodactyly (hands) (HP:0001180)3.66155223
3Abnormality of macular pigmentation (HP:0008002)3.59366805
4Chronic hepatic failure (HP:0100626)3.55682820
5Thoracolumbar scoliosis (HP:0002944)3.35081853
6Hepatoblastoma (HP:0002884)3.13018860
7Abnormal pancreas size (HP:0012094)3.10375510
8Bony spicule pigmentary retinopathy (HP:0007737)3.03914331
9Progressive cerebellar ataxia (HP:0002073)3.01872474
10Supranuclear gaze palsy (HP:0000605)2.92706051
11Pancreatic fibrosis (HP:0100732)2.82941306
12Severe visual impairment (HP:0001141)2.81974481
13Optic nerve coloboma (HP:0000588)2.81789333
14Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.78256272
15Fetal akinesia sequence (HP:0001989)2.75767693
16Diastasis recti (HP:0001540)2.74883150
17Hyperthyroidism (HP:0000836)2.69357298
18Rib fusion (HP:0000902)2.62685130
19Occipital encephalocele (HP:0002085)2.60996530
20Spastic tetraplegia (HP:0002510)2.59690025
21Impulsivity (HP:0100710)2.58719280
22Gait imbalance (HP:0002141)2.57270175
23Potter facies (HP:0002009)2.57237910
24Facial shape deformation (HP:0011334)2.57237910
25Pancreatic cysts (HP:0001737)2.56229538
26True hermaphroditism (HP:0010459)2.47570831
27Medial flaring of the eyebrow (HP:0010747)2.46423483
28Sclerocornea (HP:0000647)2.46420157
29Abnormal respiratory motile cilium physiology (HP:0012261)2.43522513
30Abnormality of the corticospinal tract (HP:0002492)2.39869087
31Vaginal atresia (HP:0000148)2.38321390
32Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.36356276
33Oligodactyly (HP:0012165)2.34139340
34Tubulointerstitial nephritis (HP:0001970)2.33877257
35Renal dysplasia (HP:0000110)2.33604420
36Nephronophthisis (HP:0000090)2.32821592
37Growth hormone deficiency (HP:0000824)2.31577544
38Drooling (HP:0002307)2.30647363
39Focal motor seizures (HP:0011153)2.29934405
40Genital tract atresia (HP:0001827)2.28909790
41Congenital primary aphakia (HP:0007707)2.28383556
42Cortical dysplasia (HP:0002539)2.27156351
43Abnormality of the aortic arch (HP:0012303)2.25811104
44Aplasia/Hypoplasia of the brainstem (HP:0007362)2.23440342
45Hypoplasia of the brainstem (HP:0002365)2.23440342
46Osteomalacia (HP:0002749)2.23150160
47Poor coordination (HP:0002370)2.23058256
48Nephrogenic diabetes insipidus (HP:0009806)2.22898909
49Anencephaly (HP:0002323)2.22790134
50Congenital malformation of the right heart (HP:0011723)2.18010431
51Double outlet right ventricle (HP:0001719)2.18010431
52Absent/shortened dynein arms (HP:0200106)2.15458403
53Dynein arm defect of respiratory motile cilia (HP:0012255)2.15458403
54Abnormality of the labia minora (HP:0012880)2.14100258
55Abnormal respiratory epithelium morphology (HP:0012253)2.10942455
56Abnormal respiratory motile cilium morphology (HP:0005938)2.10942455
57Fibular aplasia (HP:0002990)2.09860857
58Poor suck (HP:0002033)2.08554448
59Abnormality of the lower motor neuron (HP:0002366)2.08426892
60Excessive salivation (HP:0003781)2.06157821
61Focal seizures (HP:0007359)2.06102010
62Anomalous pulmonary venous return (HP:0010772)2.05627710
63Abnormal rod and cone electroretinograms (HP:0008323)1.99172365
64Pachygyria (HP:0001302)1.98800188
65Abnormal ciliary motility (HP:0012262)1.98189931
66Broad-based gait (HP:0002136)1.95906043
67Type 2 muscle fiber atrophy (HP:0003554)1.95883241
68Infertility (HP:0000789)1.95468414
69Impaired vibration sensation in the lower limbs (HP:0002166)1.94594631
70Renal hypoplasia (HP:0000089)1.94113291
71Shawl scrotum (HP:0000049)1.91718609
72Abnormality of the renal medulla (HP:0100957)1.91403958
73Multicystic kidney dysplasia (HP:0000003)1.88761952
74Agitation (HP:0000713)1.88584868
75Lipid accumulation in hepatocytes (HP:0006561)1.88471671
76Cystic liver disease (HP:0006706)1.87505347
77Muscle fiber atrophy (HP:0100295)1.86396634
78Delayed CNS myelination (HP:0002188)1.86322540
79Renal Fanconi syndrome (HP:0001994)1.85263199
80Broad alveolar ridges (HP:0000187)1.83290227
81Stage 5 chronic kidney disease (HP:0003774)1.82978273
82Megalencephaly (HP:0001355)1.82597363
83Chorioretinal atrophy (HP:0000533)1.81434487
84Molar tooth sign on MRI (HP:0002419)1.81117228
85Abnormality of midbrain morphology (HP:0002418)1.81117228
86Hemivertebrae (HP:0002937)1.80751753
87Aplasia/Hypoplasia of the earlobes (HP:0009906)1.78137341
88Volvulus (HP:0002580)1.77420539
89Anophthalmia (HP:0000528)1.77024391
90Hypoparathyroidism (HP:0000829)1.76437599
91Limb dystonia (HP:0002451)1.76367422
92Polyphagia (HP:0002591)1.76262618
93Lissencephaly (HP:0001339)1.73623550
94Specific learning disability (HP:0001328)1.72956397
95Anosmia (HP:0000458)1.72950881
96Neoplasm of the adrenal cortex (HP:0100641)1.72471581
97Hand muscle atrophy (HP:0009130)1.70851951
98Epileptic encephalopathy (HP:0200134)1.70483422
99Urinary urgency (HP:0000012)1.70340692
100Abnormality of the pulmonary veins (HP:0011718)1.70117069

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK14.14871947
2NTRK33.68534214
3CASK3.29040006
4MAP4K23.18800083
5PLK43.17916373
6MINK12.81872465
7PINK12.56149255
8INSRR2.49509688
9SIK22.42210445
10DYRK22.36492191
11ADRBK21.97497603
12WNK31.80810688
13DYRK31.77702444
14ICK1.74851695
15MAP3K41.70326876
16NTRK21.65269646
17MAP2K71.64288963
18TRIM281.63944838
19SGK2231.52728789
20SGK4941.52728789
21MAP3K91.47013512
22TYRO31.44067703
23PRKCG1.43747341
24MAP3K111.40702260
25TESK11.38428770
26PAK31.32966727
27BRD41.30906443
28RPS6KA21.25463278
29MAPK131.22503352
30DYRK1B1.20224958
31ARAF1.19260449
32CAMK1G1.14716889
33PLK21.13788165
34FRK1.12536503
35PNCK1.09104144
36PKN11.05707358
37EPHB21.05081571
38BCR1.04315612
39BMPR1B0.98315156
40CDK50.95204421
41SGK20.91918939
42PRKCZ0.91073455
43BRAF0.90805011
44CSNK1G20.90572864
45EPHA40.85518416
46CAMKK10.84129113
47DAPK20.84100879
48STK30.83986206
49STK110.79248366
50CAMKK20.74730755
51CSNK1A10.74021765
52CAMK1D0.73140732
53CSNK1E0.72761542
54MAP2K40.72737787
55PRKG10.72215641
56MAPK150.69481123
57DDR20.68527638
58ERBB20.68104143
59TLK10.66708266
60NEK20.65442648
61SGK10.62360428
62CAMK10.62325344
63PRKCQ0.61757783
64PRKACA0.60986623
65CAMK40.60767937
66NTRK10.59671900
67CDK30.58661029
68CDK140.55901731
69PHKG10.54917404
70PHKG20.54917404
71PRKCH0.54623541
72OXSR10.54054693
73GRK10.53277455
74DYRK1A0.52947611
75MAPK80.52235118
76OBSCN0.52119936
77CSNK1G30.51607431
78MATK0.50496557
79MARK30.50441990
80RPS6KA60.49724664
81CAMK2A0.49610031
82RPS6KA10.49334595
83PRKAA10.47173729
84AURKA0.45576428
85RPS6KA30.45098978
86CSNK1A1L0.44748599
87TXK0.44736011
88RPS6KL10.44725889
89RPS6KC10.44725889
90BRSK10.43805909
91PRKCB0.43489028
92STK160.43446901
93SGK30.42431359
94NUAK10.41138486
95PIK3CG0.40840806
96AKT10.40228624
97LIMK10.40160605
98SIK30.39420352
99MUSK0.37899378
100GSK3B0.37354979

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.85649003
2Phototransduction_Homo sapiens_hsa047442.85590007
3Nicotine addiction_Homo sapiens_hsa050332.74181338
4Cardiac muscle contraction_Homo sapiens_hsa042602.47703110
5Oxidative phosphorylation_Homo sapiens_hsa001902.22575195
6Parkinsons disease_Homo sapiens_hsa050122.11632867
7Olfactory transduction_Homo sapiens_hsa047402.05348872
8Synaptic vesicle cycle_Homo sapiens_hsa047212.00455619
9Primary bile acid biosynthesis_Homo sapiens_hsa001201.92895866
10GABAergic synapse_Homo sapiens_hsa047271.88865892
11Butanoate metabolism_Homo sapiens_hsa006501.77953197
12Morphine addiction_Homo sapiens_hsa050321.72436101
13Steroid biosynthesis_Homo sapiens_hsa001001.70593145
14Axon guidance_Homo sapiens_hsa043601.69428397
15Huntingtons disease_Homo sapiens_hsa050161.66016231
16Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.65268424
17Cyanoamino acid metabolism_Homo sapiens_hsa004601.61901217
18Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.61430493
19Cocaine addiction_Homo sapiens_hsa050301.60828287
20Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.60293785
21Dopaminergic synapse_Homo sapiens_hsa047281.56143937
22Phenylalanine metabolism_Homo sapiens_hsa003601.54108626
23Retinol metabolism_Homo sapiens_hsa008301.53194968
24Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.52636465
25Glutamatergic synapse_Homo sapiens_hsa047241.51409613
26Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.47483963
27Taste transduction_Homo sapiens_hsa047421.43211099
28Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.42244446
29Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.41361190
30Alzheimers disease_Homo sapiens_hsa050101.34951079
31Circadian entrainment_Homo sapiens_hsa047131.34927319
32Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.33223715
33Selenocompound metabolism_Homo sapiens_hsa004501.30381460
34Steroid hormone biosynthesis_Homo sapiens_hsa001401.29963528
35Serotonergic synapse_Homo sapiens_hsa047261.26297931
36Sulfur relay system_Homo sapiens_hsa041221.23219832
37Fatty acid biosynthesis_Homo sapiens_hsa000611.21268369
38Hedgehog signaling pathway_Homo sapiens_hsa043401.21175699
39Insulin secretion_Homo sapiens_hsa049111.18787059
40Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.13892498
41Fatty acid degradation_Homo sapiens_hsa000711.11509909
42Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.04158364
43Basal transcription factors_Homo sapiens_hsa030221.03990036
44Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.03939943
45Cholinergic synapse_Homo sapiens_hsa047251.02132116
46Amphetamine addiction_Homo sapiens_hsa050311.02014237
47Long-term depression_Homo sapiens_hsa047301.00339308
48Linoleic acid metabolism_Homo sapiens_hsa005910.99521403
49Peroxisome_Homo sapiens_hsa041460.99450549
50Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.94571869
51Arginine biosynthesis_Homo sapiens_hsa002200.93762671
52Chemical carcinogenesis_Homo sapiens_hsa052040.93105830
53Tyrosine metabolism_Homo sapiens_hsa003500.88796876
54Glycerolipid metabolism_Homo sapiens_hsa005610.87159452
55Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.86640190
56Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.86086402
57RNA polymerase_Homo sapiens_hsa030200.81716068
58Gap junction_Homo sapiens_hsa045400.80535880
59cAMP signaling pathway_Homo sapiens_hsa040240.77676069
60Tryptophan metabolism_Homo sapiens_hsa003800.76831781
61Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.75221449
62Regulation of autophagy_Homo sapiens_hsa041400.74030776
63Alcoholism_Homo sapiens_hsa050340.73454554
64Pyruvate metabolism_Homo sapiens_hsa006200.73088827
65Glycerophospholipid metabolism_Homo sapiens_hsa005640.72057819
66Caffeine metabolism_Homo sapiens_hsa002320.67997793
67Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.67508744
68Arginine and proline metabolism_Homo sapiens_hsa003300.67079058
69Notch signaling pathway_Homo sapiens_hsa043300.66522206
70Bile secretion_Homo sapiens_hsa049760.59798762
71Basal cell carcinoma_Homo sapiens_hsa052170.57116219
72Carbohydrate digestion and absorption_Homo sapiens_hsa049730.56686633
73Oxytocin signaling pathway_Homo sapiens_hsa049210.56024358
74Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.52126977
75Pentose and glucuronate interconversions_Homo sapiens_hsa000400.51380706
76Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.51186625
77PPAR signaling pathway_Homo sapiens_hsa033200.51158973
78Fatty acid metabolism_Homo sapiens_hsa012120.50258269
79Calcium signaling pathway_Homo sapiens_hsa040200.49983783
80Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.49175145
81Hippo signaling pathway_Homo sapiens_hsa043900.48269294
82Ribosome_Homo sapiens_hsa030100.48067356
83Cysteine and methionine metabolism_Homo sapiens_hsa002700.47304062
84Metabolic pathways_Homo sapiens_hsa011000.47104735
85Glucagon signaling pathway_Homo sapiens_hsa049220.46756355
86MAPK signaling pathway_Homo sapiens_hsa040100.45571930
87ABC transporters_Homo sapiens_hsa020100.43439623
88Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.42002188
89Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.41241292
90Type II diabetes mellitus_Homo sapiens_hsa049300.40492121
91VEGF signaling pathway_Homo sapiens_hsa043700.40186522
92Renin secretion_Homo sapiens_hsa049240.39903173
93Gastric acid secretion_Homo sapiens_hsa049710.39796661
94Propanoate metabolism_Homo sapiens_hsa006400.38915866
95alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.38598982
96Long-term potentiation_Homo sapiens_hsa047200.37100330
97Melanogenesis_Homo sapiens_hsa049160.36938020
98RNA transport_Homo sapiens_hsa030130.36843350
99Fat digestion and absorption_Homo sapiens_hsa049750.36196571
100Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.35849886

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