TCFL5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1piRNA metabolic process (GO:0034587)9.59253728
2cilium or flagellum-dependent cell motility (GO:0001539)9.58774911
3fusion of sperm to egg plasma membrane (GO:0007342)9.32272887
4sperm motility (GO:0030317)8.65737504
5sperm-egg recognition (GO:0035036)8.38436459
6male meiosis (GO:0007140)8.11963336
7acrosome assembly (GO:0001675)7.96206590
8binding of sperm to zona pellucida (GO:0007339)7.94185917
9axonemal dynein complex assembly (GO:0070286)7.86927458
10synaptonemal complex organization (GO:0070193)7.76521943
11synaptonemal complex assembly (GO:0007130)7.72447364
12acrosome reaction (GO:0007340)7.48064344
13cell wall macromolecule metabolic process (GO:0044036)7.47484280
14cell wall macromolecule catabolic process (GO:0016998)7.47484280
15cell-cell recognition (GO:0009988)7.43744534
16multicellular organism reproduction (GO:0032504)7.41992623
17spermatid development (GO:0007286)7.35121274
18epithelial cilium movement (GO:0003351)7.00265967
19plasma membrane fusion (GO:0045026)6.89777763
20motile cilium assembly (GO:0044458)6.88880539
21DNA methylation involved in gamete generation (GO:0043046)6.71737947
22reproduction (GO:0000003)6.10052057
23cilium movement (GO:0003341)6.03382983
24epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)6.02958523
25male meiosis I (GO:0007141)5.77194238
26regulation of cilium movement (GO:0003352)5.74789539
27chromosome organization involved in meiosis (GO:0070192)5.67457531
28meiotic nuclear division (GO:0007126)5.35718827
29microtubule depolymerization (GO:0007019)5.11262184
30single fertilization (GO:0007338)5.03217729
31DNA unwinding involved in DNA replication (GO:0006268)5.00811689
32meiosis I (GO:0007127)4.85274352
33* spermatogenesis (GO:0007283)4.82358734
34* male gamete generation (GO:0048232)4.81348534
35fertilization (GO:0009566)4.76421723
36sperm capacitation (GO:0048240)4.66587362
37germ cell development (GO:0007281)4.62862354
38nuclear pore complex assembly (GO:0051292)4.60120713
39mitotic chromosome condensation (GO:0007076)4.55848912
40* gamete generation (GO:0007276)4.44765448
41negative regulation of inclusion body assembly (GO:0090084)4.42618969
42meiotic cell cycle (GO:0051321)4.42147169
43cellular process involved in reproduction in multicellular organism (GO:0022412)4.38305580
44nuclear pore organization (GO:0006999)4.33380430
45gene silencing by RNA (GO:0031047)4.30021222
46chaperone-mediated protein complex assembly (GO:0051131)4.21424796
47regulation of meiosis I (GO:0060631)4.13000652
48regulation of translational fidelity (GO:0006450)3.97741653
49ventricular system development (GO:0021591)3.97187284
50regulation of histone H3-K9 methylation (GO:0051570)3.92755815
51DNA replication-dependent nucleosome assembly (GO:0006335)3.89239629
52DNA replication-dependent nucleosome organization (GO:0034723)3.89239629
53meiotic cell cycle process (GO:1903046)3.88893803
54regulation of inclusion body assembly (GO:0090083)3.88445008
55regulation of mammary gland epithelial cell proliferation (GO:0033599)3.85584930
56seminiferous tubule development (GO:0072520)3.78999220
57microtubule severing (GO:0051013)3.78716573
58regulation of centriole replication (GO:0046599)3.77926806
59ribosomal small subunit biogenesis (GO:0042274)3.70116886
60chromosome condensation (GO:0030261)3.66174846
61DNA packaging (GO:0006323)3.62159632
62mitotic sister chromatid segregation (GO:0000070)3.58572469
63regulation of microtubule-based movement (GO:0060632)3.56545582
64synapsis (GO:0007129)3.55763982
65monoubiquitinated protein deubiquitination (GO:0035520)3.53775042
66protein K6-linked ubiquitination (GO:0085020)3.49048520
67pore complex assembly (GO:0046931)3.48325300
68heterochromatin organization (GO:0070828)3.46193912
69* multicellular organismal reproductive process (GO:0048609)3.44895138
70gene silencing (GO:0016458)3.43913711
71DNA alkylation (GO:0006305)3.43757908
72DNA methylation (GO:0006306)3.43757908
73cell recognition (GO:0008037)3.42395550
74regulation of spindle checkpoint (GO:0090231)3.37578508
75DNA replication checkpoint (GO:0000076)3.36855664
76sister chromatid segregation (GO:0000819)3.36358243
77histone exchange (GO:0043486)3.35809273
78organic cation transport (GO:0015695)3.35072468
79cellular protein complex localization (GO:0034629)3.26938379
80single strand break repair (GO:0000012)3.26783432
81regulation of posttranscriptional gene silencing (GO:0060147)3.24373539
82regulation of gene silencing by miRNA (GO:0060964)3.24373539
83regulation of gene silencing by RNA (GO:0060966)3.24373539
84genitalia morphogenesis (GO:0035112)3.21566640
85nucleus organization (GO:0006997)3.16584269
86regulation of mitotic spindle organization (GO:0060236)3.16262885
87proline biosynthetic process (GO:0006561)3.16042971
88mitotic sister chromatid cohesion (GO:0007064)3.15959372
89positive regulation of DNA-dependent DNA replication (GO:2000105)3.12260312
90negative regulation of DNA repair (GO:0045738)3.11848016
91regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.11827464
92protein complex localization (GO:0031503)3.09972008
93negative regulation of organelle assembly (GO:1902116)3.09806954
94maturation of SSU-rRNA (GO:0030490)3.09639989
95spliceosomal tri-snRNP complex assembly (GO:0000244)3.09299568
96DNA strand elongation involved in DNA replication (GO:0006271)3.03999646
97protein polyglutamylation (GO:0018095)3.02405608
98protein localization to chromosome, centromeric region (GO:0071459)2.98999972
99DNA strand elongation (GO:0022616)2.98591982
100regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.97378109
101microtubule polymerization or depolymerization (GO:0031109)2.94469426
102calcium ion-dependent exocytosis (GO:0017156)2.94153128
103spermatid nucleus differentiation (GO:0007289)2.94046111
104reciprocal DNA recombination (GO:0035825)2.90927916
105reciprocal meiotic recombination (GO:0007131)2.90927916
106left/right pattern formation (GO:0060972)2.90617496
107regulation of protein polyubiquitination (GO:1902914)2.90018695
108DNA replication initiation (GO:0006270)2.89680427
109regulation of centrosome cycle (GO:0046605)2.88539101
110protein export from nucleus (GO:0006611)2.87316626
111peptidyl-lysine dimethylation (GO:0018027)2.82118029
112regulation of nucleobase-containing compound transport (GO:0032239)2.81584801
113DNA methylation or demethylation (GO:0044728)2.81484090
114sister chromatid cohesion (GO:0007062)2.81011212
115intraciliary transport (GO:0042073)2.80495701
116protein localization to cilium (GO:0061512)2.80269827
117blastocyst development (GO:0001824)2.80190568
118DNA damage induced protein phosphorylation (GO:0006975)2.78690190
119chromatin silencing (GO:0006342)2.78674299
120interferon-gamma secretion (GO:0072643)2.77409358
121DNA duplex unwinding (GO:0032508)2.77340823
122protein localization to kinetochore (GO:0034501)2.77102264
123cell-substrate adherens junction assembly (GO:0007045)2.75574674
124focal adhesion assembly (GO:0048041)2.75574674
125* multicellular organismal development (GO:0007275)2.73932886
126melanin biosynthetic process (GO:0042438)2.71051865
127regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.69171875
128mitotic metaphase plate congression (GO:0007080)2.69149523
129biotin metabolic process (GO:0006768)2.68716550
130mitotic nuclear envelope disassembly (GO:0007077)2.67769416
131regulation of early endosome to late endosome transport (GO:2000641)2.67523977
132adherens junction assembly (GO:0034333)2.66610726
133regulation of RNA export from nucleus (GO:0046831)2.66512602
134DNA topological change (GO:0006265)2.64345536
135histone H2B ubiquitination (GO:0033523)2.64322877
136activation of Rac GTPase activity (GO:0032863)2.63098847
137regulation of glucocorticoid metabolic process (GO:0031943)2.61733119
138DNA conformation change (GO:0071103)2.61621707
139membrane disassembly (GO:0030397)2.61408636
140nuclear envelope disassembly (GO:0051081)2.61408636
141notochord development (GO:0030903)2.61321414
142G1 DNA damage checkpoint (GO:0044783)2.61268404
143nucleobase-containing small molecule interconversion (GO:0015949)2.58863948
144RNA localization (GO:0006403)2.58533116
145nucleosome disassembly (GO:0006337)2.57935476
146protein-DNA complex disassembly (GO:0032986)2.57935476
147COPI coating of Golgi vesicle (GO:0048205)2.57447038
148Golgi transport vesicle coating (GO:0048200)2.57447038
149DNA geometric change (GO:0032392)2.56011840
150formation of translation preinitiation complex (GO:0001731)2.55744323
151histone phosphorylation (GO:0016572)2.55645802
152synaptic vesicle docking involved in exocytosis (GO:0016081)2.52593070
153protein retention in ER lumen (GO:0006621)2.51226044
154protein localization to microtubule (GO:0035372)2.51096344
155DNA synthesis involved in DNA repair (GO:0000731)2.46440041
156positive regulation of chromosome segregation (GO:0051984)2.46401919
157mitotic G1 DNA damage checkpoint (GO:0031571)2.44645988
158telomere maintenance via semi-conservative replication (GO:0032201)2.43631006
159chromatin assembly (GO:0031497)2.43062686
160melanin metabolic process (GO:0006582)2.42462100
161maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.42109040
162maternal placenta development (GO:0001893)2.40955136
163regulation of spindle organization (GO:0090224)2.40189705
164mitotic cytokinesis (GO:0000281)2.39801352
165regulation of sister chromatid cohesion (GO:0007063)2.39737031
166regulation of translational termination (GO:0006449)2.39501854
167positive regulation of dendritic spine morphogenesis (GO:0061003)2.37550652
168L-serine metabolic process (GO:0006563)2.36342642
169positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.34707941
170regulation of histone H3-K27 methylation (GO:0061085)2.34578948
171paraxial mesoderm development (GO:0048339)2.33986212
172folic acid metabolic process (GO:0046655)2.33750532
173proline metabolic process (GO:0006560)2.32174041
174adenine nucleotide transport (GO:0051503)2.32150820
175peptidyl-arginine omega-N-methylation (GO:0035247)2.31778255
176negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.31120473
177regulation of translational elongation (GO:0006448)2.28283737
178negative regulation of telomerase activity (GO:0051974)2.27296696
179cytoskeletal anchoring at plasma membrane (GO:0007016)2.27140460
180regulation of DNA-dependent DNA replication (GO:0090329)2.26856432
181nuclear envelope organization (GO:0006998)2.23896001
182central nervous system myelination (GO:0022010)2.21612193
183axon ensheathment in central nervous system (GO:0032291)2.21612193
184cellular response to epidermal growth factor stimulus (GO:0071364)2.21364462
185peptidyl-threonine modification (GO:0018210)2.20499577
186peptidyl-threonine phosphorylation (GO:0018107)2.19314103

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.27043273
2FOXM1_23109430_ChIP-Seq_U2OS_Human2.94513820
3HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.85488453
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.56538318
5* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.56402430
6TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.55100737
7NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.33820027
8TP63_17297297_ChIP-ChIP_HaCaT_Human2.32497779
9GATA1_26923725_Chip-Seq_HPCs_Mouse2.23165007
10E2F4_17652178_ChIP-ChIP_JURKAT_Human2.20887998
11SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.16446351
12BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.14650117
13MYC_22102868_ChIP-Seq_BL_Human2.13735761
14ZFX_18555785_ChIP-Seq_MESCs_Mouse2.13707297
15ZNF263_19887448_ChIP-Seq_K562_Human2.13097842
16KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.10619788
17KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.10619788
18KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.10619788
19FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.07672681
20MYC_18555785_ChIP-Seq_MESCs_Mouse2.03847177
21STAT6_21828071_ChIP-Seq_BEAS2B_Human2.00859093
22MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse10.6349131
23CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.98451908
24SALL1_21062744_ChIP-ChIP_HESCs_Human1.98089062
25THAP11_20581084_ChIP-Seq_MESCs_Mouse1.89438925
26ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.85934676
27MYC_19079543_ChIP-ChIP_MESCs_Mouse1.84778969
28NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.82818176
29MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.82732931
30ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.78494980
31TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.78043500
32RACK7_27058665_Chip-Seq_MCF-7_Human1.75680709
33MYCN_18555785_ChIP-Seq_MESCs_Mouse1.74023582
34E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.69487630
35TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.67908260
36KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.63902881
37CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.62786584
38EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.62620489
39ESR1_15608294_ChIP-ChIP_MCF-7_Human1.62472512
40EZH2_22144423_ChIP-Seq_EOC_Human1.62148733
41CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.58040435
42MYC_18358816_ChIP-ChIP_MESCs_Mouse1.56590732
43MYC_19030024_ChIP-ChIP_MESCs_Mouse1.56278064
44MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.55525488
45FLI1_27457419_Chip-Seq_LIVER_Mouse1.54782603
46PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.54128412
47KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.54057793
48ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.53536894
49SOX2_18555785_ChIP-Seq_MESCs_Mouse1.53107638
50POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.51794850
51EGR1_19374776_ChIP-ChIP_THP-1_Human1.51688765
52WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.48853104
53AR_21909140_ChIP-Seq_LNCAP_Human1.48166817
54* KDM2B_26808549_Chip-Seq_K562_Human1.45209546
55VDR_21846776_ChIP-Seq_THP-1_Human1.44894963
56CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.43579366
57KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.42481679
58PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.39150952
59TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.38693183
60ESR2_21235772_ChIP-Seq_MCF-7_Human1.37179648
61SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.36911962
62ZFP281_18757296_ChIP-ChIP_E14_Mouse1.35719420
63TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.34214683
64CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.33910997
65PCGF2_27294783_Chip-Seq_ESCs_Mouse1.33371271
66P300_27058665_Chip-Seq_ZR-75-30cells_Human1.31881935
67PKCTHETA_26484144_Chip-Seq_BREAST_Human1.31308136
68ELK3_25401928_ChIP-Seq_HUVEC_Human1.31000797
69LXR_22292898_ChIP-Seq_THP-1_Human1.30573188
70RBPJ_22232070_ChIP-Seq_NCS_Mouse1.28533358
71ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.27962548
72ELK4_26923725_Chip-Seq_MESODERM_Mouse1.27715740
73CHD1_26751641_Chip-Seq_LNCaP_Human1.25316855
74STAT3_1855785_ChIP-Seq_MESCs_Mouse1.24927994
75FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.21175736
76KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.20582140
77KAP1_22055183_ChIP-Seq_ESCs_Mouse1.20043068
78KDM2B_26808549_Chip-Seq_SUP-B15_Human1.19719544
79SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.19426734
80ZNF274_21170338_ChIP-Seq_K562_Hela1.18091343
81ATF3_27146783_Chip-Seq_COLON_Human1.16948450
82TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.16753611
83KDM2B_26808549_Chip-Seq_DND41_Human1.16437542
84THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.16413534
85JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.15799417
86DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.15703310
87KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.15625292
88TCF7_22412390_ChIP-Seq_EML_Mouse1.15412112
89TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.14590613
90SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.14310254
91* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.14124092
92CLOCK_20551151_ChIP-Seq_293T_Human1.13723662
93HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.12593732
94POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.12510907
95VDR_22108803_ChIP-Seq_LS180_Human1.12502623
96ZFP281_27345836_Chip-Seq_ESCs_Mouse1.12343650
97* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.11373258
98UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.09741963
99PCGF2_27294783_Chip-Seq_NPCs_Mouse1.08448387
100KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.06886857
101HIF1A_21447827_ChIP-Seq_MCF-7_Human1.06703001
102SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.06519349
103YY1_22570637_ChIP-Seq_MALME-3M_Human1.05893516
104SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.05815438
105E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.05798716
106P68_20966046_ChIP-Seq_HELA_Human1.05781994
107CREB1_26743006_Chip-Seq_LNCaP_Human1.05561384
108TET1_21451524_ChIP-Seq_MESCs_Mouse1.05456196
109* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.04978259
110CREB1_15753290_ChIP-ChIP_HEK293T_Human1.03333068
111UBF1/2_26484160_Chip-Seq_HMECs_Human1.03277552
112CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.02378987
113XRN2_22483619_ChIP-Seq_HELA_Human1.01719016
114ETS1_20019798_ChIP-Seq_JURKAT_Human1.01054983
115NELFA_20434984_ChIP-Seq_ESCs_Mouse1.00978931
116SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.00768110
117RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.00603810
118TBX5_21415370_ChIP-Seq_HL-1_Mouse1.00084116
119GATA3_21867929_ChIP-Seq_CD8_Mouse1.00062793
120RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.99782109
121DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.99703541
122RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.99483644
123EST1_17652178_ChIP-ChIP_JURKAT_Human0.99149964
124KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.98894226
125KDM2B_26808549_Chip-Seq_JURKAT_Human0.97705947
126ERG_21242973_ChIP-ChIP_JURKAT_Human0.97600491
127SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.97586461
128WDR5_24793694_ChIP-Seq_LNCAP_Human0.97156253
129NANOG_18555785_ChIP-Seq_MESCs_Mouse0.95696011
130KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.95016620
131GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse0.94495520
132STAT1_17558387_ChIP-Seq_HELA_Human0.93025955
133CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.92433959
134YY1_21170310_ChIP-Seq_MESCs_Mouse0.92358326
135EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.91622565
136POU5F1_16518401_ChIP-PET_MESCs_Mouse0.90611159
137SOX2_22085726_ChIP-Seq_NPCs_Mouse0.90080709
138E2F1_21310950_ChIP-Seq_MCF-7_Human0.88580036
139GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.88563492
140TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.88146895
141PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.88009571
142TCF3_18692474_ChIP-Seq_MESCs_Mouse0.87485507
143RUNX1_26923725_Chip-Seq_HPCs_Mouse0.86681410
144NFE2_27457419_Chip-Seq_LIVER_Mouse0.85601374
145TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.85336885
146FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.85315054
147POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.84859187
148NANOG_21062744_ChIP-ChIP_HESCs_Human0.84563138
149SOX2_18692474_ChIP-Seq_MESCs_Mouse0.84427375
150TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.84318138
151POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.83845086
152* RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.83835070
153NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.83775110
154GABP_19822575_ChIP-Seq_HepG2_Human0.81745615
155LUZP1_20508642_ChIP-Seq_ESCs_Mouse0.79863191
156DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.78101280
157RARA_24833708_ChIP-Seq_LIVER_Mouse0.77536578
158NANOG_18692474_ChIP-Seq_MESCs_Mouse0.76847729
159KDM5A_27292631_Chip-Seq_BREAST_Human0.76707392
160* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.76232262
161STAT3_18555785_ChIP-Seq_MESCs_Mouse0.76227851
162DCP1A_22483619_ChIP-Seq_HELA_Human0.75984303
163VDR_23849224_ChIP-Seq_CD4+_Human0.74524088
164TTF2_22483619_ChIP-Seq_HELA_Human0.73636180
165SUZ12_27294783_Chip-Seq_NPCs_Mouse0.73029875
166PHF8_20622854_ChIP-Seq_HELA_Human0.72939386

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation5.99962653
2MP0003698_abnormal_male_reproductive4.68467404
3MP0001929_abnormal_gametogenesis4.66467043
4MP0002877_abnormal_melanocyte_morpholog3.89838419
5MP0002210_abnormal_sex_determination3.70815162
6MP0008057_abnormal_DNA_replication3.45847222
7MP0002653_abnormal_ependyma_morphology3.25622920
8MP0001145_abnormal_male_reproductive3.17802770
9MP0010094_abnormal_chromosome_stability2.84640531
10MP0004185_abnormal_adipocyte_glucose2.78159826
11MP0000653_abnormal_sex_gland2.71525401
12MP0002161_abnormal_fertility/fecundity2.64625866
13MP0003111_abnormal_nucleus_morphology2.51807498
14MP0008058_abnormal_DNA_repair2.51225598
15MP0005409_darkened_coat_color2.51128562
16MP0004957_abnormal_blastocyst_morpholog2.26246132
17MP0005171_absent_coat_pigmentation2.22984722
18MP0005623_abnormal_meninges_morphology2.14928567
19MP0003693_abnormal_embryo_hatching2.12485983
20MP0003077_abnormal_cell_cycle2.05228316
21MP0005410_abnormal_fertilization10.5040487
22MP0002160_abnormal_reproductive_system1.97272949
23MP0000566_synostosis1.81581549
24MP0010234_abnormal_vibrissa_follicle1.79467289
25MP0003786_premature_aging1.74672965
26MP0001730_embryonic_growth_arrest1.70054700
27MP0001346_abnormal_lacrimal_gland1.66066073
28MP0008007_abnormal_cellular_replicative1.62420374
29MP0004133_heterotaxia1.61800093
30MP0002249_abnormal_larynx_morphology1.61252750
31MP0002089_abnormal_postnatal_growth/wei1.61024518
32MP0008932_abnormal_embryonic_tissue1.52691811
33MP0001293_anophthalmia1.52498960
34MP0003942_abnormal_urinary_system1.52223546
35MP0005408_hypopigmentation1.39764826
36MP0005670_abnormal_white_adipose1.39615445
37MP0002084_abnormal_developmental_patter1.39568230
38MP0009780_abnormal_chondrocyte_physiolo1.31106110
39MP0010307_abnormal_tumor_latency1.28378783
40MP0003890_abnormal_embryonic-extraembry1.27699827
41MP0000579_abnormal_nail_morphology1.27572207
42MP0002085_abnormal_embryonic_tissue1.27382178
43MP0002009_preneoplasia1.24698939
44MP0005380_embryogenesis_phenotype1.22272649
45MP0001672_abnormal_embryogenesis/_devel1.22272649
46MP0004858_abnormal_nervous_system1.21590502
47MP0002282_abnormal_trachea_morphology1.21374739
48MP0000003_abnormal_adipose_tissue1.19971427
49MP0004197_abnormal_fetal_growth/weight/1.19922697
50MP0003646_muscle_fatigue1.19628132
51MP0008995_early_reproductive_senescence1.18692394
52MP0009379_abnormal_foot_pigmentation1.18645715
53MP0003123_paternal_imprinting1.18447704
54MP0001697_abnormal_embryo_size1.16726233
55MP0000350_abnormal_cell_proliferation1.16384421
56MP0005389_reproductive_system_phenotype1.14651256
57MP0004381_abnormal_hair_follicle1.12461919
58MP0005501_abnormal_skin_physiology1.07179773
59MP0005377_hearing/vestibular/ear_phenot1.04336361
60MP0003878_abnormal_ear_physiology1.04336361
61MP0003119_abnormal_digestive_system1.03758412
62MP0004233_abnormal_muscle_weight1.02473039
63MP0002396_abnormal_hematopoietic_system1.02377091
64MP0005621_abnormal_cell_physiology1.01612646
65MP0003984_embryonic_growth_retardation1.01222559
66MP0003950_abnormal_plasma_membrane1.00721596
67MP0010352_gastrointestinal_tract_polyps1.00576398
68MP0009384_cardiac_valve_regurgitation1.00229415
69MP0000733_abnormal_muscle_development0.98243596
70MP0008260_abnormal_autophagy0.97438785
71MP0002088_abnormal_embryonic_growth/wei0.97164745
72MP0002080_prenatal_lethality0.96264406
73MP0004272_abnormal_basement_membrane0.95240566
74MP0004859_abnormal_synaptic_plasticity0.93974229
75MP0001186_pigmentation_phenotype0.92911887
76MP0002075_abnormal_coat/hair_pigmentati0.91556865
77MP0003566_abnormal_cell_adhesion0.90897699
78MP0005384_cellular_phenotype0.90202077
79MP0003861_abnormal_nervous_system0.88414599
80MP0005257_abnormal_intraocular_pressure0.88236968
81MP0001348_abnormal_lacrimal_gland0.87632209
82MP0002086_abnormal_extraembryonic_tissu0.87355419
83MP0003718_maternal_effect0.87147925
84MP0000762_abnormal_tongue_morphology0.86825855
85MP0003136_yellow_coat_color0.86347445
86MP0003937_abnormal_limbs/digits/tail_de0.86205593
87MP0003941_abnormal_skin_development0.83993733
88MP0005375_adipose_tissue_phenotype0.83862546
89MP0010630_abnormal_cardiac_muscle0.82059399
90MP0001915_intracranial_hemorrhage0.81542131
91MP0004134_abnormal_chest_morphology0.81379402
92MP0000537_abnormal_urethra_morphology0.80269988
93MP0000313_abnormal_cell_death0.80130362
94MP0003385_abnormal_body_wall0.79256399
95MP0008438_abnormal_cutaneous_collagen0.78963116
96MP0003115_abnormal_respiratory_system0.77828392
97MP0001188_hyperpigmentation0.76738917
98MP0009697_abnormal_copulation0.76478679
99MP0000432_abnormal_head_morphology0.76439250
100MP0003453_abnormal_keratinocyte_physiol0.75824288
101MP0002163_abnormal_gland_morphology0.75731440
102MP0001270_distended_abdomen0.75346582
103MP0005647_abnormal_sex_gland0.74274798
104MP0000377_abnormal_hair_follicle0.73712352
105MP0002092_abnormal_eye_morphology0.73664463
106MP0000371_diluted_coat_color0.72895376
107MP0005451_abnormal_body_composition0.72582337
108MP0000678_abnormal_parathyroid_gland0.71377234
109MP0001661_extended_life_span0.71350344
110MP0002060_abnormal_skin_morphology0.70173833
111MP0005423_abnormal_somatic_nervous0.69815008
112MP0003121_genomic_imprinting0.69209273
113MP0005076_abnormal_cell_differentiation0.69206028
114MP0000358_abnormal_cell_content/0.68665354
115MP0002697_abnormal_eye_size0.68119336
116MP0001119_abnormal_female_reproductive0.67956809
117MP0003699_abnormal_female_reproductive0.67837276
118MP0003315_abnormal_perineum_morphology0.67808780
119MP0003936_abnormal_reproductive_system0.67233795
120MP0009672_abnormal_birth_weight0.65588397
121MP0000462_abnormal_digestive_system0.64270408
122MP0009703_decreased_birth_body0.61984004
123MP0003283_abnormal_digestive_organ0.60073009
124MP0005391_vision/eye_phenotype0.60032872
125MP0002111_abnormal_tail_morphology0.53976727
126MP0001727_abnormal_embryo_implantation0.53490834
127MP0002114_abnormal_axial_skeleton0.52675887
128MP0003705_abnormal_hypodermis_morpholog0.52352549
129MP0001849_ear_inflammation0.50325049
130MP0010030_abnormal_orbit_morphology0.50242658
131MP0004264_abnormal_extraembryonic_tissu0.49450200
132MP0003787_abnormal_imprinting0.48490990
133MP0003806_abnormal_nucleotide_metabolis0.47939603
134MP0000427_abnormal_hair_cycle0.46653882
135MP0006072_abnormal_retinal_apoptosis0.46528953
136MP0005666_abnormal_adipose_tissue0.45584532
137MP0002233_abnormal_nose_morphology0.45353742
138MP0002116_abnormal_craniofacial_bone0.45353354
139MP0002152_abnormal_brain_morphology0.43989463
140MP0002269_muscular_atrophy0.43042603
141MP0000534_abnormal_ureter_morphology0.42938789
142MP0001286_abnormal_eye_development0.42837108
143MP0002019_abnormal_tumor_incidence0.42737286
144MP0009278_abnormal_bone_marrow0.41467747
145MP0002234_abnormal_pharynx_morphology0.40558917
146MP0009053_abnormal_anal_canal0.40262814
147MP0000428_abnormal_craniofacial_morphol0.39648482
148MP0003935_abnormal_craniofacial_develop0.39353932
149MP0002102_abnormal_ear_morphology0.38955599

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)7.80639131
2Abnormal respiratory motile cilium morphology (HP:0005938)7.33332834
3Abnormal respiratory epithelium morphology (HP:0012253)7.33332834
4Rhinitis (HP:0012384)6.59847355
5Chronic bronchitis (HP:0004469)6.41470560
6Abnormal ciliary motility (HP:0012262)6.23762928
7Infertility (HP:0000789)5.30017962
8Nasal polyposis (HP:0100582)4.56650392
9Nephronophthisis (HP:0000090)3.92258078
10Bronchiectasis (HP:0002110)3.76899970
11Abnormality of the lower motor neuron (HP:0002366)3.63014812
12Abnormality of the nasal mucosa (HP:0000433)3.54128784
13Bronchitis (HP:0012387)3.49137015
14Impulsivity (HP:0100710)3.37989304
15Abnormal spermatogenesis (HP:0008669)3.31993873
16Male infertility (HP:0003251)3.23958802
17Supernumerary spleens (HP:0009799)3.15267476
18Hyperacusis (HP:0010780)3.11913497
19Insomnia (HP:0100785)3.02748487
20Gonadotropin excess (HP:0000837)3.00571354
21Increased nuchal translucency (HP:0010880)2.97800744
22Abnormality of the renal medulla (HP:0100957)2.89626853
23Ulnar bowing (HP:0003031)2.71484721
24Protrusio acetabuli (HP:0003179)2.69729427
25Amyotrophic lateral sclerosis (HP:0007354)2.68748334
26Azoospermia (HP:0000027)2.65415964
27Asymmetry of the thorax (HP:0001555)2.64731553
28Septate vagina (HP:0001153)2.52820048
29Recurrent otitis media (HP:0000403)2.49643522
30Fibular hypoplasia (HP:0003038)2.48602658
31Tubular atrophy (HP:0000092)2.48042754
32Abnormality of the phalanges of the hallux (HP:0010057)2.47212467
33Broad distal phalanx of finger (HP:0009836)2.44777622
34Tubulointerstitial nephritis (HP:0001970)2.41867371
35Selective tooth agenesis (HP:0001592)2.39299507
36Germ cell neoplasia (HP:0100728)2.38944394
37Molar tooth sign on MRI (HP:0002419)2.37910415
38Abnormality of midbrain morphology (HP:0002418)2.37910415
39Short ribs (HP:0000773)2.35989617
4011 pairs of ribs (HP:0000878)2.35352476
41Abnormality of the anterior horn cell (HP:0006802)2.33612055
42Degeneration of anterior horn cells (HP:0002398)2.33612055
43Hypoplasia of the capital femoral epiphysis (HP:0003090)2.32276682
44Overriding aorta (HP:0002623)2.30017503
45Progressive muscle weakness (HP:0003323)2.28150825
46Turricephaly (HP:0000262)2.27832477
47Abnormality of the aortic arch (HP:0012303)2.25340110
48Microvesicular hepatic steatosis (HP:0001414)2.24180385
49Renal duplication (HP:0000075)2.21917488
50Facial cleft (HP:0002006)2.21781063
51Deviation of the thumb (HP:0009603)2.18987475
52Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.15667584
53Absent epiphyses (HP:0010577)2.15667584
54Birth length less than 3rd percentile (HP:0003561)2.12896329
55Proximal placement of thumb (HP:0009623)2.12502835
56Abnormality of the distal phalanx of the thumb (HP:0009617)2.11555026
57Recurrent sinusitis (HP:0011108)2.10992902
58Ankyloglossia (HP:0010296)2.10914364
59Deep palmar crease (HP:0006191)2.10882494
60Duplication of thumb phalanx (HP:0009942)2.07679035
61Aplasia/Hypoplasia of the sacrum (HP:0008517)2.06069571
62Vertebral compression fractures (HP:0002953)2.03859893
63Syringomyelia (HP:0003396)2.03324147
64Spinal cord lesions (HP:0100561)2.03324147
65Coronal craniosynostosis (HP:0004440)2.01800898
66Microglossia (HP:0000171)2.00893519
67Reticulocytopenia (HP:0001896)2.00859373
68Respiratory insufficiency due to defective ciliary clearance (HP:0200073)11.2739522
69Dynein arm defect of respiratory motile cilia (HP:0012255)10.2016959
70Absent/shortened dynein arms (HP:0200106)10.2016959
71Tubulointerstitial abnormality (HP:0001969)1.99248453
72Upper motor neuron abnormality (HP:0002127)1.98874268
73Postaxial foot polydactyly (HP:0001830)1.97930871
74Deep philtrum (HP:0002002)1.94667016
75Ependymoma (HP:0002888)1.94034692
76Aplasia/hypoplasia of the humerus (HP:0006507)1.93985456
77Macroorchidism (HP:0000053)1.93559026
78Deep venous thrombosis (HP:0002625)1.92821801
79Carpal bone hypoplasia (HP:0001498)1.91289273
80Testicular neoplasm (HP:0010788)1.90393581
81Short humerus (HP:0005792)1.90088058
82Missing ribs (HP:0000921)1.89263982
83Heterotopia (HP:0002282)1.87694369
84Ectopic kidney (HP:0000086)1.86296092
85Medial flaring of the eyebrow (HP:0010747)1.85696375
86Relative macrocephaly (HP:0004482)1.84727685
87Aplasia/Hypoplasia of the fibula (HP:0006492)1.83969895
88Arnold-Chiari malformation (HP:0002308)1.83779134
89Elfin facies (HP:0004428)1.83253329
90Hypopigmentation of the fundus (HP:0007894)1.82036377
91Termporal pattern (HP:0011008)1.79936174
92Insidious onset (HP:0003587)1.79936174
93Annular pancreas (HP:0001734)1.79829697
94Abdominal situs inversus (HP:0003363)1.78649496
95Abnormality of abdominal situs (HP:0011620)1.78649496
96Sparse lateral eyebrow (HP:0005338)1.77879848
97Irregular epiphyses (HP:0010582)1.77275080
98Median cleft lip (HP:0000161)1.76928092
99Abnormality of the umbilical cord (HP:0010881)1.76016151
100Back pain (HP:0003418)1.75237923
101Facial hemangioma (HP:0000329)1.74329916
102Abnormality of cochlea (HP:0000375)1.74159455
103Obsessive-compulsive behavior (HP:0000722)1.73376964
104Leiomyosarcoma (HP:0100243)1.72753591
105Uterine leiomyosarcoma (HP:0002891)1.72753591
106Abnormality of chromosome segregation (HP:0002916)1.72676600
107Sloping forehead (HP:0000340)1.71807076
108Achilles tendon contracture (HP:0001771)1.71632552
109Cutaneous melanoma (HP:0012056)1.71082133
110Abnormality of the distal phalanges of the toes (HP:0010182)1.70618420
111Embryonal neoplasm (HP:0002898)1.70575668
112Limited elbow extension (HP:0001377)1.69391604
113Disproportionate tall stature (HP:0001519)1.69122227
114Morphological abnormality of the inner ear (HP:0011390)1.68867890
115Atresia of the external auditory canal (HP:0000413)1.68352059
116Stage 5 chronic kidney disease (HP:0003774)1.68255268
117Shallow orbits (HP:0000586)1.68193396
118Spinal cord compression (HP:0002176)1.66751773
119Abnormality of the fetal cardiovascular system (HP:0010948)1.64971655
120Abnormal umbilical cord blood vessels (HP:0011403)1.64971655
121Single umbilical artery (HP:0001195)1.64971655
122Nephroblastoma (Wilms tumor) (HP:0002667)1.64587034
123Meckel diverticulum (HP:0002245)1.64399467
124Short thorax (HP:0010306)1.63933598
125Aplasia/Hypoplasia of the uvula (HP:0010293)1.63788130
126Abnormality of dentin (HP:0010299)1.63701366
127Long palpebral fissure (HP:0000637)1.63529553
128Abnormality of the acetabulum (HP:0003170)1.63193985
129Patellar dislocation (HP:0002999)1.62940646
130Short nail (HP:0001799)1.62613024
131Renovascular hypertension (HP:0100817)1.62357246
132Urethral obstruction (HP:0000796)1.61906396
133Partial duplication of thumb phalanx (HP:0009944)1.61502804
134Oculomotor apraxia (HP:0000657)1.61209808
135Pointed chin (HP:0000307)1.60409248
136Abnormality of glycolysis (HP:0004366)1.60013638
137Flat acetabular roof (HP:0003180)1.59988719
138Renal cell carcinoma (HP:0005584)1.59492306
139Chromosomal breakage induced by crosslinking agents (HP:0003221)1.59407805
140Neoplasm of the oral cavity (HP:0100649)1.59263266
141Medulloblastoma (HP:0002885)1.59262367
142Congenital hepatic fibrosis (HP:0002612)1.57828318
143Abnormality of the ileum (HP:0001549)1.57612489
144Impaired proprioception (HP:0010831)1.57536940
145Mitral regurgitation (HP:0001653)1.56960789
146Abnormality of the Achilles tendon (HP:0005109)1.56591331
147Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.55949621
148Partial duplication of the phalanx of hand (HP:0009999)1.55502712
149Dysmetric saccades (HP:0000641)1.54698404
150Dislocated radial head (HP:0003083)1.54688262
151Premature rupture of membranes (HP:0001788)1.54578825
152Recurrent bronchitis (HP:0002837)1.54247985
153Thickened helices (HP:0000391)1.54221040
154Premature skin wrinkling (HP:0100678)1.54099864
155Chromsome breakage (HP:0040012)1.54018176
156Ragged-red muscle fibers (HP:0003200)1.53882346
157Breast hypoplasia (HP:0003187)1.52663130
158Testicular atrophy (HP:0000029)1.52428407
159Abnormality of the labia minora (HP:0012880)1.52262768
160Deviation of the hallux (HP:0010051)1.51595401
161Absent thumb (HP:0009777)1.50989228
162Embryonal renal neoplasm (HP:0011794)1.50802631
163Bell-shaped thorax (HP:0001591)1.50664335
164Tubulointerstitial fibrosis (HP:0005576)1.49604533
165Abnormality of chromosome stability (HP:0003220)1.48914335
166Absent radius (HP:0003974)1.47283188
167Abnormality of the astrocytes (HP:0100707)1.46293469
168Astrocytoma (HP:0009592)1.46293469
169Abnormality of the preputium (HP:0100587)1.44685287
170Absent frontal sinuses (HP:0002688)1.43689216
171Supernumerary ribs (HP:0005815)1.43178845
172Rhizomelia (HP:0008905)1.42881524
173Atrophy/Degeneration involving motor neurons (HP:0007373)1.41011297
174Renal dysplasia (HP:0000110)1.40960842
175Postaxial hand polydactyly (HP:0001162)1.40029723
176Small epiphyses (HP:0010585)1.39501612
177Hypoplasia of the radius (HP:0002984)1.38259811
178Aplasia involving forearm bones (HP:0009822)1.37754073
179Absent forearm bone (HP:0003953)1.37754073
180Abnormal drinking behavior (HP:0030082)1.36313468
181Polydipsia (HP:0001959)1.36313468
182Abnormal connection of the cardiac segments (HP:0011545)1.35818258
183Abnormal ventriculo-arterial connection (HP:0011563)1.35818258
184Transposition of the great arteries (HP:0001669)1.35818258
185Supernumerary bones of the axial skeleton (HP:0009144)1.34228152

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK37.00830505
2PDK47.00830505
3PDK24.67708321
4TRIB34.42885148
5TESK14.07466222
6ICK3.92330952
7PRKD33.34281798
8PNCK3.18040886
9IRAK32.86038245
10CDK122.69620193
11NEK22.68417369
12CDC72.51043011
13WEE12.49675441
14SMG12.36360109
15SCYL22.35835975
16STK392.20017914
17EPHA22.14971745
18SIK11.98803440
19NME21.94056493
20TTK1.91871604
21TAOK21.81580896
22WNK41.71681103
23BUB11.70950322
24PRPF4B1.62278356
25PTK2B1.56669769
26MAP3K91.50346062
27PKN21.50049952
28TYRO31.47508799
29PDGFRA1.29760715
30CHEK21.27442013
31PASK1.23878788
32DYRK31.20793362
33STK38L1.19597134
34STK381.19193337
35SRPK11.18898735
36MST1R1.16102383
37CHEK11.15974076
38STK31.14178255
39CDK81.13702012
40PLK11.10780322
41ATR1.07551740
42ARAF1.05649986
43KSR21.05441443
44LMTK20.98797831
45MAPKAPK50.92468486
46CDK70.91416227
47NTRK10.89813961
48PLK40.89115283
49PTK20.87630853
50ATM0.83379451
51SIK20.82946474
52WNK10.77891833
53CDK11A0.77870240
54DMPK0.75952670
55ERBB40.75586199
56BRSK20.72914509
57MINK10.72403045
58CDK180.72160996
59BRD40.72157851
60TESK20.71436156
61MAP2K30.69141121
62MTOR0.68645210
63MAP3K20.68306846
64FGFR20.66595366
65AKT20.66438316
66RET0.66210047
67PAK60.65469725
68EIF2AK10.63242363
69AURKA0.62902748
70PAK10.61968516
71DYRK1B0.61623314
72FGFR40.59870119
73MAP2K20.59153708
74RIPK10.58846932
75CDK40.58762524
76ILK0.58281534
77CDK140.58214017
78PLK30.57078535
79EPHA40.55009664
80LRRK20.55007932
81CDK20.54177274
82PAK40.54100819
83AURKB0.53813222
84CAMKK10.52861519
85ACVR1B0.52112810
86MARK20.51851132
87MAPK150.51424716
88LATS10.50921209
89PDK10.49895347
90PBK0.49377849
91CCNB10.48249571
92PTK60.47182092
93CDK90.46678496
94MAPK110.46389955
95MET0.46053568
96RPS6KB20.45484892
97MKNK20.45048048
98CSNK1D0.43837957
99TLK10.43589958
100SGK30.43480878
101CDK10.43418427
102CAMK1D0.43269382
103EEF2K0.42791708
104LATS20.42076762
105TSSK60.41928161
106STK40.39198950
107BRAF0.37692868
108CSNK2A20.37626536
109IRAK10.37015459
110WNK30.35151081
111MKNK10.34823255
112NEK60.32321857
113PAK20.30436417
114MAP3K80.29684854
115CSNK1E0.29116803
116CSNK2A10.29009177
117MELK0.28489471
118PRKDC0.28355163
119BRSK10.25591591
120STK100.24638296
121GSK3B0.24133200
122BCR0.22980932
123ALK0.22305867
124NEK10.22132241
125VRK10.20914209
126RPS6KB10.20888835
127PRKCI0.20847824
128DYRK20.20587498
129AKT30.19225557
130PIM10.18984324
131DDR20.18471604
132CDK60.17502674
133MAPK10.14288646
134PINK10.13661812
135CLK10.13355720
136MAPK100.13136567
137MAP3K100.13080693
138RPS6KA50.12258975
139MAPK140.11663234
140IRAK20.11530419
141MAPK80.11264818
142PDPK10.11104920
143RPS6KA10.10171705
144CDK150.10008691
145CAMK1G0.09705664

Predicted pathways (KEGG)

RankGene SetZ-score
1Basal transcription factors_Homo sapiens_hsa030223.82687236
2Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.52682385
3RNA transport_Homo sapiens_hsa030133.51139993
4Fanconi anemia pathway_Homo sapiens_hsa034603.28687174
5Vitamin B6 metabolism_Homo sapiens_hsa007503.26777868
6mRNA surveillance pathway_Homo sapiens_hsa030152.76924411
7Mismatch repair_Homo sapiens_hsa034302.73706544
8DNA replication_Homo sapiens_hsa030302.71592941
9Spliceosome_Homo sapiens_hsa030402.59341267
10Homologous recombination_Homo sapiens_hsa034402.50462505
11Glycolysis / Gluconeogenesis_Homo sapiens_hsa000102.39636671
12Selenocompound metabolism_Homo sapiens_hsa004502.28446089
13Fatty acid biosynthesis_Homo sapiens_hsa000612.25976882
14Pyruvate metabolism_Homo sapiens_hsa006202.13700798
15Cell cycle_Homo sapiens_hsa041102.12965313
16Oocyte meiosis_Homo sapiens_hsa041142.11553141
17RNA polymerase_Homo sapiens_hsa030202.06009273
18Nucleotide excision repair_Homo sapiens_hsa034202.03670689
19Proteasome_Homo sapiens_hsa030502.03346192
20Linoleic acid metabolism_Homo sapiens_hsa005911.93791490
21alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.88638943
22Dorso-ventral axis formation_Homo sapiens_hsa043201.85612431
23Non-small cell lung cancer_Homo sapiens_hsa052231.85545795
24Non-homologous end-joining_Homo sapiens_hsa034501.78824471
25Thyroid cancer_Homo sapiens_hsa052161.76455830
26Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.75426772
27Pentose phosphate pathway_Homo sapiens_hsa000301.72329667
28Pyrimidine metabolism_Homo sapiens_hsa002401.68394956
29Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.67717663
30Glioma_Homo sapiens_hsa052141.66614602
31Base excision repair_Homo sapiens_hsa034101.65508342
32Chronic myeloid leukemia_Homo sapiens_hsa052201.63369625
33RNA degradation_Homo sapiens_hsa030181.62589984
34Cysteine and methionine metabolism_Homo sapiens_hsa002701.52716670
35Endometrial cancer_Homo sapiens_hsa052131.51540823
36Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.44379309
37Glucagon signaling pathway_Homo sapiens_hsa049221.41407896
38Purine metabolism_Homo sapiens_hsa002301.39102232
39Hedgehog signaling pathway_Homo sapiens_hsa043401.36659660
40Systemic lupus erythematosus_Homo sapiens_hsa053221.36596129
41VEGF signaling pathway_Homo sapiens_hsa043701.36452854
42ErbB signaling pathway_Homo sapiens_hsa040121.31861780
43Bladder cancer_Homo sapiens_hsa052191.27331090
44Huntingtons disease_Homo sapiens_hsa050161.22184656
45One carbon pool by folate_Homo sapiens_hsa006701.22008018
46Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.19496597
47Basal cell carcinoma_Homo sapiens_hsa052171.18950730
48Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.17901419
49Pancreatic cancer_Homo sapiens_hsa052121.17245607
50Ether lipid metabolism_Homo sapiens_hsa005651.14760498
51Sulfur relay system_Homo sapiens_hsa041221.13623302
52Propanoate metabolism_Homo sapiens_hsa006401.13169301
53Neurotrophin signaling pathway_Homo sapiens_hsa047221.07325662
54Small cell lung cancer_Homo sapiens_hsa052221.06155976
55Prion diseases_Homo sapiens_hsa050201.04537950
56Renal cell carcinoma_Homo sapiens_hsa052111.04280378
57Biosynthesis of amino acids_Homo sapiens_hsa012301.02876805
58Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.02748703
59Glycerophospholipid metabolism_Homo sapiens_hsa005641.02730184
60Glycerolipid metabolism_Homo sapiens_hsa005610.98891824
61Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.97567920
62p53 signaling pathway_Homo sapiens_hsa041150.97393243
63Phosphatidylinositol signaling system_Homo sapiens_hsa040700.97183827
64Fructose and mannose metabolism_Homo sapiens_hsa000510.95757427
65Prostate cancer_Homo sapiens_hsa052150.94596502
66Colorectal cancer_Homo sapiens_hsa052100.94210111
67Proteoglycans in cancer_Homo sapiens_hsa052050.94014072
68Insulin signaling pathway_Homo sapiens_hsa049100.92438917
69Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.90947560
70Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.90085423
71Antigen processing and presentation_Homo sapiens_hsa046120.89677815
72Melanogenesis_Homo sapiens_hsa049160.86971038
73Glutathione metabolism_Homo sapiens_hsa004800.85525952
74Carbon metabolism_Homo sapiens_hsa012000.84384671
75Longevity regulating pathway - mammal_Homo sapiens_hsa042110.84073749
76Hippo signaling pathway_Homo sapiens_hsa043900.83302575
77GnRH signaling pathway_Homo sapiens_hsa049120.82933750
78Acute myeloid leukemia_Homo sapiens_hsa052210.82191729
79Choline metabolism in cancer_Homo sapiens_hsa052310.81836991
80Viral carcinogenesis_Homo sapiens_hsa052030.81407324
812-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.80618246
82Thyroid hormone synthesis_Homo sapiens_hsa049180.79774907
83Epstein-Barr virus infection_Homo sapiens_hsa051690.78523136
84Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.78179523
85Tight junction_Homo sapiens_hsa045300.75893221
86Phospholipase D signaling pathway_Homo sapiens_hsa040720.74387758
87Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.72390887
88Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.69652715
89Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.69070203
90Fat digestion and absorption_Homo sapiens_hsa049750.68232302
91Ribosome_Homo sapiens_hsa030100.68145554
92Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.67656194
93Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.67065775
94Melanoma_Homo sapiens_hsa052180.65912850
95N-Glycan biosynthesis_Homo sapiens_hsa005100.65868093
96Alcoholism_Homo sapiens_hsa050340.65695967
97Central carbon metabolism in cancer_Homo sapiens_hsa052300.65426549
98Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.64824772
99Wnt signaling pathway_Homo sapiens_hsa043100.64327761
100Arachidonic acid metabolism_Homo sapiens_hsa005900.61625493
101Sphingolipid signaling pathway_Homo sapiens_hsa040710.57859628
102Folate biosynthesis_Homo sapiens_hsa007900.57279248
103Focal adhesion_Homo sapiens_hsa045100.56843124
104Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.55364351
105Arginine and proline metabolism_Homo sapiens_hsa003300.53148895
106Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.52482028
107TGF-beta signaling pathway_Homo sapiens_hsa043500.50076520
108Pathways in cancer_Homo sapiens_hsa052000.47807408
109Synaptic vesicle cycle_Homo sapiens_hsa047210.47206031
110MAPK signaling pathway_Homo sapiens_hsa040100.44328793
111HTLV-I infection_Homo sapiens_hsa051660.41689557
112Steroid biosynthesis_Homo sapiens_hsa001000.41543579
113Mineral absorption_Homo sapiens_hsa049780.40556121
114AMPK signaling pathway_Homo sapiens_hsa041520.38354787
115Sphingolipid metabolism_Homo sapiens_hsa006000.37055987
116Protein digestion and absorption_Homo sapiens_hsa049740.34803499
117Notch signaling pathway_Homo sapiens_hsa043300.32918002
118Amphetamine addiction_Homo sapiens_hsa050310.32136011
119MicroRNAs in cancer_Homo sapiens_hsa052060.32006167
120Cardiac muscle contraction_Homo sapiens_hsa042600.31537843
121Metabolic pathways_Homo sapiens_hsa011000.31023975
122Adherens junction_Homo sapiens_hsa045200.30960503
123Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.29729966
124PPAR signaling pathway_Homo sapiens_hsa033200.28216367
125Estrogen signaling pathway_Homo sapiens_hsa049150.27739973
126Renin-angiotensin system_Homo sapiens_hsa046140.25653903
127Carbohydrate digestion and absorption_Homo sapiens_hsa049730.24822666
128Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.22923552
129Herpes simplex infection_Homo sapiens_hsa051680.22775696
130Fatty acid metabolism_Homo sapiens_hsa012120.22003098
131Lysine degradation_Homo sapiens_hsa003100.19569577
132ECM-receptor interaction_Homo sapiens_hsa045120.19405538
133Thyroid hormone signaling pathway_Homo sapiens_hsa049190.17939720
134Endocytosis_Homo sapiens_hsa041440.17269551
135Inositol phosphate metabolism_Homo sapiens_hsa005620.15455090
136Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.15429982
137Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.14446662
138mTOR signaling pathway_Homo sapiens_hsa041500.14071233
139HIF-1 signaling pathway_Homo sapiens_hsa040660.12090467
140Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.11751128
141Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.09948970
142Legionellosis_Homo sapiens_hsa051340.09282215
143Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.09149589
144Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.08490051
145Axon guidance_Homo sapiens_hsa043600.06201829
146Long-term potentiation_Homo sapiens_hsa047200.06013249

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