TCF3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the E protein (class I) family of helix-loop-helix transcription factors. E proteins activate transcription by binding to regulatory E-box sequences on target genes as heterodimers or homodimers, and are inhibited by heterodimerization with inhibitor of DNA-binding (class IV) helix-loop-helix proteins. E proteins play a critical role in lymphopoiesis, and the encoded protein is required for B and T lymphocyte development. Deletion of this gene or diminished activity of the encoded protein may play a role in lymphoid malignancies. This gene is also involved in several chromosomal translocations that are associated with lymphoid malignancies including pre-B-cell acute lymphoblastic leukemia (t(1;19), with PBX1), childhood leukemia (t(19;19), with TFPT) and acute leukemia (t(12;19), with ZNF384). Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the short arm of chromosome 9. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA unwinding involved in DNA replication (GO:0006268)5.48868390
2protein localization to kinetochore (GO:0034501)4.44198595
3negative regulation of mRNA splicing, via spliceosome (GO:0048025)4.40080299
4planar cell polarity pathway involved in neural tube closure (GO:0090179)4.35182017
5negative regulation of RNA splicing (GO:0033119)4.12653842
6regulation of histone H3-K9 methylation (GO:0051570)4.07252878
7regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.98844708
8viral transcription (GO:0019083)3.97525798
9heterochromatin organization (GO:0070828)3.86419935
10protein localization to chromosome, centromeric region (GO:0071459)3.86101492
11DNA strand elongation involved in DNA replication (GO:0006271)3.85987017
12protein-DNA complex disassembly (GO:0032986)3.80887012
13nucleosome disassembly (GO:0006337)3.80887012
14negative regulation of mRNA processing (GO:0050686)3.78963772
15translational termination (GO:0006415)3.78287295
16negative regulation of histone methylation (GO:0031061)3.76178003
17DNA strand elongation (GO:0022616)3.63984239
18sister chromatid segregation (GO:0000819)3.63518470
19regulation of RNA export from nucleus (GO:0046831)3.59958408
20regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.54737836
21mitotic sister chromatid segregation (GO:0000070)3.51085556
22ribosomal small subunit assembly (GO:0000028)3.50118671
23DNA replication initiation (GO:0006270)3.48105988
24chromatin assembly (GO:0031497)3.45864690
25telomere maintenance via semi-conservative replication (GO:0032201)3.45595407
26convergent extension (GO:0060026)3.45491305
27DNA duplex unwinding (GO:0032508)3.44929754
28nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.42869102
29regulation of chromatin binding (GO:0035561)3.41567153
30DNA replication-dependent nucleosome assembly (GO:0006335)3.41413812
31DNA replication-dependent nucleosome organization (GO:0034723)3.41413812
32DNA geometric change (GO:0032392)3.40321194
33negative regulation of mRNA metabolic process (GO:1903312)3.39856112
34translational elongation (GO:0006414)3.39368290
35mitotic nuclear envelope disassembly (GO:0007077)3.37132331
36dosage compensation (GO:0007549)3.33810622
37mitotic chromosome condensation (GO:0007076)3.28994863
38pre-miRNA processing (GO:0031054)3.28332210
39apoptotic process involved in morphogenesis (GO:0060561)3.26783243
40chromosome condensation (GO:0030261)3.21985887
41regulation of NFAT protein import into nucleus (GO:0051532)3.19103192
42translesion synthesis (GO:0019985)3.16876765
43translational initiation (GO:0006413)3.15878981
44paraxial mesoderm development (GO:0048339)3.12823617
45alternative mRNA splicing, via spliceosome (GO:0000380)3.12728550
46regulation of mammary gland epithelial cell proliferation (GO:0033599)3.12342490
47regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.11915721
48nuclear envelope disassembly (GO:0051081)3.11618212
49membrane disassembly (GO:0030397)3.11618212
503-UTR-mediated mRNA stabilization (GO:0070935)3.10409193
51formation of translation preinitiation complex (GO:0001731)3.09766480
52peptidyl-arginine N-methylation (GO:0035246)3.09426173
53peptidyl-arginine methylation (GO:0018216)3.09426173
54intracellular estrogen receptor signaling pathway (GO:0030520)3.07918022
55RNA stabilization (GO:0043489)3.07641071
56mRNA stabilization (GO:0048255)3.07641071
57protein complex disassembly (GO:0043241)3.05723071
58chromatin assembly or disassembly (GO:0006333)3.05689665
59histone arginine methylation (GO:0034969)3.05283535
60mitotic recombination (GO:0006312)3.03837672
61regulation of sister chromatid cohesion (GO:0007063)3.01928104
62protein complex localization (GO:0031503)3.01411704
63ATP-dependent chromatin remodeling (GO:0043044)3.00673819
64negative regulation of gene expression, epigenetic (GO:0045814)2.99632698
65DNA topological change (GO:0006265)2.99018475
66regulation of translational fidelity (GO:0006450)2.98717943
67nuclear pore complex assembly (GO:0051292)2.98103839
68nuclear pore organization (GO:0006999)2.96906093
69telomere maintenance via recombination (GO:0000722)2.96621913
70maturation of SSU-rRNA (GO:0030490)2.96436422
71positive regulation of chromosome segregation (GO:0051984)2.96390598
72proline biosynthetic process (GO:0006561)2.95439756
73regulation of nucleobase-containing compound transport (GO:0032239)2.95329131
74positive regulation by host of viral transcription (GO:0043923)2.94893642
75cellular protein complex disassembly (GO:0043624)2.94185342
76mitotic sister chromatid cohesion (GO:0007064)2.93117362
77viral life cycle (GO:0019058)2.91576239
78protein localization to chromosome (GO:0034502)2.91387852
79SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.90922214
80ribosomal small subunit biogenesis (GO:0042274)2.90402719
81regulation of mRNA stability (GO:0043488)2.90074856
82positive regulation of gene expression, epigenetic (GO:0045815)2.89361189
83mRNA splicing, via spliceosome (GO:0000398)2.87518910
84RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.87518910
85folic acid-containing compound biosynthetic process (GO:0009396)2.86834872
86nucleotide-excision repair, DNA gap filling (GO:0006297)2.85393377
87pore complex assembly (GO:0046931)2.84783959
88RNA splicing, via transesterification reactions (GO:0000375)2.83813518
89protein targeting to ER (GO:0045047)2.82177500
90chromatin silencing (GO:0006342)2.82072882
91DNA replication checkpoint (GO:0000076)2.80839930
92cotranslational protein targeting to membrane (GO:0006613)2.80121587
93macromolecular complex disassembly (GO:0032984)2.79790416
94regulation of histone H3-K27 methylation (GO:0061085)2.79459667
95cellular protein complex localization (GO:0034629)2.78833930
96termination of RNA polymerase II transcription (GO:0006369)2.78599841
97DNA conformation change (GO:0071103)2.77367802
98base-excision repair (GO:0006284)2.77265143
99telomere maintenance via telomere lengthening (GO:0010833)2.74304660
100regulation of glucose import in response to insulin stimulus (GO:2001273)2.73184722
101Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.72779212
102establishment of integrated proviral latency (GO:0075713)2.72742785
103nuclear-transcribed mRNA catabolic process (GO:0000956)2.71505213
104regulation of RNA stability (GO:0043487)2.71356603
105cellular response to epidermal growth factor stimulus (GO:0071364)2.69729923
106regulation of gamma-delta T cell differentiation (GO:0045586)2.69317752
107positive regulation of DNA-dependent DNA replication (GO:2000105)2.68260412
108establishment of protein localization to endoplasmic reticulum (GO:0072599)2.67010146
109positive regulation of transcription regulatory region DNA binding (GO:2000679)2.65760346
110DNA synthesis involved in DNA repair (GO:0000731)2.64568146
111positive regulation of gamma-delta T cell activation (GO:0046645)2.64428562
112postreplication repair (GO:0006301)2.63104028
113regulation of stem cell maintenance (GO:2000036)2.62990504
114glucocorticoid receptor signaling pathway (GO:0042921)2.62679009
115peptidyl-arginine omega-N-methylation (GO:0035247)2.62578724
116negative regulation of gene silencing (GO:0060969)2.62040483
117positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.60877394
118spliceosomal tri-snRNP complex assembly (GO:0000244)2.60728719
119RNA catabolic process (GO:0006401)2.60698934
120kinetochore organization (GO:0051383)2.60606337
121mitotic metaphase plate congression (GO:0007080)2.60576868
122histone H3-K36 demethylation (GO:0070544)2.60571621
123DNA packaging (GO:0006323)2.60221494
124adherens junction assembly (GO:0034333)2.58947404
125regulation of protein heterodimerization activity (GO:0043497)2.58602968
126regulation of gene silencing (GO:0060968)2.58583312
127mRNA catabolic process (GO:0006402)2.58485893
128cellular hyperosmotic response (GO:0071474)2.58453695
129regulation of gene silencing by RNA (GO:0060966)2.58242838
130regulation of posttranscriptional gene silencing (GO:0060147)2.58242838
131regulation of gene silencing by miRNA (GO:0060964)2.58242838
132peptidyl-lysine dimethylation (GO:0018027)2.58082405
133regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.57815926
134regulation of establishment of planar polarity (GO:0090175)2.57721842
135protein export from nucleus (GO:0006611)2.54731607
136activation of Rac GTPase activity (GO:0032863)2.52545233
137cell-substrate adherens junction assembly (GO:0007045)2.50392821

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.00102850
2FOXM1_23109430_ChIP-Seq_U2OS_Human5.15609262
3* MYC_22102868_ChIP-Seq_BL_Human3.79641252
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.39751126
5EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.34636470
6FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.06289609
7EGR1_19374776_ChIP-ChIP_THP-1_Human3.04186090
8MYC_18555785_ChIP-Seq_MESCs_Mouse2.96409885
9VDR_21846776_ChIP-Seq_THP-1_Human2.73258736
10MYC_19079543_ChIP-ChIP_MESCs_Mouse2.37954289
11CIITA_25753668_ChIP-Seq_RAJI_Human2.12439253
12* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.09231496
13TP63_19390658_ChIP-ChIP_HaCaT_Human2.01462766
14MYC_19030024_ChIP-ChIP_MESCs_Mouse1.97198630
15XRN2_22483619_ChIP-Seq_HELA_Human1.95910376
16E2F1_21310950_ChIP-Seq_MCF-7_Human1.92853249
17* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.84104676
18* TCF7_22412390_ChIP-Seq_EML_Mouse1.79335600
19MYC_18358816_ChIP-ChIP_MESCs_Mouse1.76240584
20MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.75595721
21NELFA_20434984_ChIP-Seq_ESCs_Mouse1.74394990
22TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.66282595
23* UTX_26944678_Chip-Seq_JUKART_Human1.63981071
24AR_21909140_ChIP-Seq_LNCAP_Human1.63207657
25KDM2B_26808549_Chip-Seq_DND41_Human1.61506887
26CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.59501019
27* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.57291885
28* ELK3_25401928_ChIP-Seq_HUVEC_Human1.56926239
29* MAF_26560356_Chip-Seq_TH1_Human1.54928241
30EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.54619083
31RACK7_27058665_Chip-Seq_MCF-7_Human1.54389534
32SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.52507956
33MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.52243484
34* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.51905696
35ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.48307172
36* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.46817914
37TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.46403794
38* SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.40908960
39* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.39218731
40DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.37851692
41SCL_19346495_ChIP-Seq_HPC-7_Human1.36634816
42ZNF263_19887448_ChIP-Seq_K562_Human1.35600136
43FOXP3_21729870_ChIP-Seq_TREG_Human1.35382607
44KDM5A_27292631_Chip-Seq_BREAST_Human1.34219466
45VDR_24763502_ChIP-Seq_THP-1_Human1.34023070
46ETS1_20019798_ChIP-Seq_JURKAT_Human1.33745854
47HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.30826937
48MYCN_18555785_ChIP-Seq_MESCs_Mouse1.30705853
49* KDM2B_26808549_Chip-Seq_K562_Human1.30036392
50ZFX_18555785_ChIP-Seq_MESCs_Mouse1.29676385
51KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.29658083
52NANOG_18555785_ChIP-Seq_MESCs_Mouse1.28597773
53POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.27550154
54EST1_17652178_ChIP-ChIP_JURKAT_Human1.26345645
55ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.25995395
56TTF2_22483619_ChIP-Seq_HELA_Human1.25468891
57WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.24938851
58VDR_23849224_ChIP-Seq_CD4+_Human1.24926780
59FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.24260314
60NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.23786848
61RBPJ_22232070_ChIP-Seq_NCS_Mouse1.22530468
62CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.20135298
63THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.19775668
64SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.19258899
65* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.17440580
66KLF4_18555785_ChIP-Seq_MESCs_Mouse1.17327326
67KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.15521558
68SOX2_18555785_ChIP-Seq_MESCs_Mouse1.15034855
69TET1_21451524_ChIP-Seq_MESCs_Mouse1.14568703
70* KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.14268128
71P300_27058665_Chip-Seq_ZR-75-30cells_Human1.14212942
72GABP_19822575_ChIP-Seq_HepG2_Human1.14199293
73ELF1_17652178_ChIP-ChIP_JURKAT_Human1.13644832
74MYB_26560356_Chip-Seq_TH2_Human1.13597920
75ESR1_15608294_ChIP-ChIP_MCF-7_Human1.12575420
76SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.12131015
77MYB_26560356_Chip-Seq_TH1_Human1.12048829
78* MAF_26560356_Chip-Seq_TH2_Human1.11376093
79CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.10707207
80CREB1_15753290_ChIP-ChIP_HEK293T_Human1.09859211
81NCOR1_26117541_ChIP-Seq_K562_Human1.08295361
82* POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.07883166
83P68_20966046_ChIP-Seq_HELA_Human1.07617520
84E2F1_18555785_ChIP-Seq_MESCs_Mouse1.06770042
85SRY_22984422_ChIP-ChIP_TESTIS_Rat1.05769456
86CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.04911407
87SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.04674937
88ERG_21242973_ChIP-ChIP_JURKAT_Human1.04467846
89CTCF_27219007_Chip-Seq_ERYTHROID_Human1.03696089
90* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.03574146
91* SA1_27219007_Chip-Seq_ERYTHROID_Human1.03291859
92STAT3_1855785_ChIP-Seq_MESCs_Mouse1.03146160
93DCP1A_22483619_ChIP-Seq_HELA_Human1.02814811
94* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.02654578
95* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.02598106
96CLOCK_20551151_ChIP-Seq_293T_Human1.02107468
97E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.02073867
98* NANOG_21062744_ChIP-ChIP_HESCs_Human1.01404827
99YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.00642798
100MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.00616462
101* ZFP281_18757296_ChIP-ChIP_E14_Mouse0.99947519
102RARG_19884340_ChIP-ChIP_MEFs_Mouse0.99781635
103KDM2B_26808549_Chip-Seq_JURKAT_Human0.99729289
104KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.99645971
105KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.99645971
106KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.99645971
107* ZFP281_27345836_Chip-Seq_ESCs_Mouse0.99427198
108* DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.98639100
109ERG_20887958_ChIP-Seq_HPC-7_Mouse0.98295585
110* CREB1_26743006_Chip-Seq_LNCaP_Human0.98180517
111KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.96898424
112THAP11_20581084_ChIP-Seq_MESCs_Mouse0.96893204
113* BRD4_27068464_Chip-Seq_AML-cells_Mouse0.96298952
114TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.95940967
115RUNX1_22412390_ChIP-Seq_EML_Mouse0.95552537
116LXR_22292898_ChIP-Seq_THP-1_Human0.94839110
117* TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.94422029
118HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.94066214
119* CHD1_26751641_Chip-Seq_LNCaP_Human0.93909058
120TFEB_21752829_ChIP-Seq_HELA_Human0.93658239
121CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.92856965
122HOXB4_20404135_ChIP-ChIP_EML_Mouse0.92644034
123CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.92100753
124SPI1_23547873_ChIP-Seq_NB4_Human0.91492936
125* GATA1_22383799_ChIP-Seq_G1ME_Mouse0.91106864
126TP63_17297297_ChIP-ChIP_HaCaT_Human0.88730666
127FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.88726540
128GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.87876633
129PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.86854970
130TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.85921343
131ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.84677085

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability3.24046023
2MP0003111_abnormal_nucleus_morphology3.21766113
3MP0003077_abnormal_cell_cycle2.92679239
4MP0003693_abnormal_embryo_hatching2.86911889
5MP0004957_abnormal_blastocyst_morpholog2.81528395
6MP0010352_gastrointestinal_tract_polyps2.51621269
7MP0008057_abnormal_DNA_replication2.43521230
8MP0006054_spinal_hemorrhage2.40222065
9MP0009278_abnormal_bone_marrow2.33129522
10MP0005076_abnormal_cell_differentiation2.28530525
11MP0003705_abnormal_hypodermis_morpholog2.27989030
12MP0000566_synostosis2.12519552
13MP0010030_abnormal_orbit_morphology2.09235773
14MP0001730_embryonic_growth_arrest2.01028372
15MP0008007_abnormal_cellular_replicative1.96991639
16* MP0000350_abnormal_cell_proliferation1.96644222
17MP0003123_paternal_imprinting1.91571858
18* MP0004808_abnormal_hematopoietic_stem1.81539413
19MP0004185_abnormal_adipocyte_glucose1.80039879
20MP0004197_abnormal_fetal_growth/weight/1.78891074
21MP0000537_abnormal_urethra_morphology1.78445683
22MP0000490_abnormal_crypts_of1.68726980
23* MP0002396_abnormal_hematopoietic_system1.65026779
24* MP0000703_abnormal_thymus_morphology1.63510760
25MP0002085_abnormal_embryonic_tissue1.62565682
26MP0005380_embryogenesis_phenotype1.61025904
27MP0001672_abnormal_embryogenesis/_devel1.61025904
28MP0009053_abnormal_anal_canal1.60636800
29MP0002877_abnormal_melanocyte_morpholog1.58368163
30MP0008058_abnormal_DNA_repair1.56946803
31MP0008932_abnormal_embryonic_tissue1.56285050
32MP0002084_abnormal_developmental_patter1.56165526
33MP0001697_abnormal_embryo_size1.55920447
34* MP0002398_abnormal_bone_marrow1.54755821
35MP0010307_abnormal_tumor_latency1.54311343
36MP0003984_embryonic_growth_retardation1.53302785
37MP0002088_abnormal_embryonic_growth/wei1.51089968
38MP0004858_abnormal_nervous_system1.48390292
39MP0003121_genomic_imprinting1.45211345
40MP0001849_ear_inflammation1.43581151
41MP0002080_prenatal_lethality1.43316579
42MP0002086_abnormal_extraembryonic_tissu1.43233856
43MP0001545_abnormal_hematopoietic_system1.42992481
44MP0005397_hematopoietic_system_phenotyp1.42992481
45MP0000733_abnormal_muscle_development1.38308536
46* MP0002019_abnormal_tumor_incidence1.38306647
47MP0005257_abnormal_intraocular_pressure1.37858499
48MP0001800_abnormal_humoral_immune1.36626608
49MP0003763_abnormal_thymus_physiology1.35276746
50* MP0002722_abnormal_immune_system1.34605683
51MP0009379_abnormal_foot_pigmentation1.30422807
52MP0000678_abnormal_parathyroid_gland1.30422495
53MP0003567_abnormal_fetal_cardiomyocyte1.29143670
54* MP0000689_abnormal_spleen_morphology1.26829555
55MP0000428_abnormal_craniofacial_morphol1.25871503
56MP0005451_abnormal_body_composition1.21579122
57MP0001293_anophthalmia1.21159105
58MP0001346_abnormal_lacrimal_gland1.20626177
59MP0003300_gastrointestinal_ulcer1.20424190
60MP0002653_abnormal_ependyma_morphology1.20294620
61* MP0000313_abnormal_cell_death1.19784542
62MP0002009_preneoplasia1.19334746
63MP0001915_intracranial_hemorrhage1.18589499
64MP0002932_abnormal_joint_morphology1.16869536
65MP0003115_abnormal_respiratory_system1.16153367
66MP0003861_abnormal_nervous_system1.14377376
67MP0002092_abnormal_eye_morphology1.13405345
68MP0003303_peritoneal_inflammation1.12812868
69MP0002796_impaired_skin_barrier1.12545130
70MP0009333_abnormal_splenocyte_physiolog1.10679143
71* MP0002429_abnormal_blood_cell1.10229945
72* MP0000716_abnormal_immune_system1.07725380
73MP0003566_abnormal_cell_adhesion1.06579493
74MP0005409_darkened_coat_color1.05118507
75MP0003119_abnormal_digestive_system1.04835459
76* MP0000685_abnormal_immune_system1.04393841
77* MP0005501_abnormal_skin_physiology1.02704094
78MP0005623_abnormal_meninges_morphology1.02203743
79MP0005023_abnormal_wound_healing1.01725791
80MP0002925_abnormal_cardiovascular_devel1.01374577
81MP0009672_abnormal_birth_weight1.00526428
82MP0000762_abnormal_tongue_morphology0.99903156
83MP0003315_abnormal_perineum_morphology0.99607372
84MP0001348_abnormal_lacrimal_gland0.99105755
85MP0004264_abnormal_extraembryonic_tissu0.98555753
86MP0005621_abnormal_cell_physiology0.96749222
87* MP0002452_abnormal_antigen_presenting0.96576449
88MP0003935_abnormal_craniofacial_develop0.96063048
89MP0002116_abnormal_craniofacial_bone0.95539589
90MP0002166_altered_tumor_susceptibility0.95255872
91MP0003091_abnormal_cell_migration0.94426974
92MP0003937_abnormal_limbs/digits/tail_de0.93066497
93MP0002111_abnormal_tail_morphology0.92494928
94MP0004233_abnormal_muscle_weight0.91791224
95MP0000477_abnormal_intestine_morphology0.90392468
96MP0006292_abnormal_olfactory_placode0.90010842
97MP0003385_abnormal_body_wall0.89565473
98MP0000049_abnormal_middle_ear0.89358462
99MP0009703_decreased_birth_body0.89105910
100* MP0002420_abnormal_adaptive_immunity0.88792503
101MP0002249_abnormal_larynx_morphology0.87095012
102MP0003755_abnormal_palate_morphology0.86995713
103MP0010630_abnormal_cardiac_muscle0.86659497
104MP0004272_abnormal_basement_membrane0.86526970
105* MP0001819_abnormal_immune_cell0.86357369
106MP0000462_abnormal_digestive_system0.86286724
107MP0002282_abnormal_trachea_morphology0.85933025
108MP0002697_abnormal_eye_size0.85526738
109MP0005666_abnormal_adipose_tissue0.83330334
110MP0000534_abnormal_ureter_morphology0.83249952
111MP0003938_abnormal_ear_development0.81272516
112MP0008438_abnormal_cutaneous_collagen0.80859588
113MP0000432_abnormal_head_morphology0.80030554
114MP0002114_abnormal_axial_skeleton0.79678105
115MP0001790_abnormal_immune_system0.79156642
116MP0005387_immune_system_phenotype0.79156642
117MP0008877_abnormal_DNA_methylation0.78983841
118MP0003279_aneurysm0.78555709
119MP0003942_abnormal_urinary_system0.78460161
120MP0010234_abnormal_vibrissa_follicle0.77647611
121MP0002081_perinatal_lethality0.77415503
122MP0008770_decreased_survivor_rate0.76955728
123MP0000858_altered_metastatic_potential0.76610614
124MP0003786_premature_aging0.75602263
125MP0003890_abnormal_embryonic-extraembry0.75390447
126MP0002254_reproductive_system_inflammat0.75237678
127MP0001286_abnormal_eye_development0.74841285
128MP0008789_abnormal_olfactory_epithelium0.74630145
129MP0000266_abnormal_heart_morphology0.74088843
130MP0001784_abnormal_fluid_regulation0.73452261
131MP0003283_abnormal_digestive_organ0.72735726
132MP0003122_maternal_imprinting0.71682365
133MP0002723_abnormal_immune_serum0.71522643
134MP0002405_respiratory_system_inflammati0.71456768
135MP0002089_abnormal_postnatal_growth/wei0.71383950

Predicted human phenotypes

RankGene SetZ-score
1Short 4th metacarpal (HP:0010044)3.59622138
2Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.59622138
3Agammaglobulinemia (HP:0004432)3.34448421
4Hyperacusis (HP:0010780)3.18752709
5Selective tooth agenesis (HP:0001592)2.78222410
6Abnormality of the 4th metacarpal (HP:0010012)2.77778033
7High anterior hairline (HP:0009890)2.76583379
8* Papilloma (HP:0012740)2.74324407
9* Verrucae (HP:0200043)2.74324407
10* Cellulitis (HP:0100658)2.74313067
11Increased nuchal translucency (HP:0010880)2.73708679
12Renal duplication (HP:0000075)2.72277008
13Ulnar bowing (HP:0003031)2.68880014
14Reticulocytopenia (HP:0001896)2.66296041
15B lymphocytopenia (HP:0010976)2.65803420
16Abnormality of B cell number (HP:0010975)2.65803420
17Abnormality of the fingertips (HP:0001211)2.64373118
18Abnormality of the intervertebral disk (HP:0005108)2.61942443
19Long palpebral fissure (HP:0000637)2.60136808
20Colon cancer (HP:0003003)2.58787530
21Medulloblastoma (HP:0002885)2.58323878
22Abnormality of cells of the erythroid lineage (HP:0012130)2.57983372
23Abnormal number of incisors (HP:0011064)2.56899239
24Ependymoma (HP:0002888)2.51917274
25Disproportionate tall stature (HP:0001519)2.46157772
26Long eyelashes (HP:0000527)2.45578749
27Basal cell carcinoma (HP:0002671)2.44997572
28Asymmetry of the thorax (HP:0001555)2.43462477
29Patellar aplasia (HP:0006443)2.41816291
30Deep palmar crease (HP:0006191)2.41431747
31Abnormal number of erythroid precursors (HP:0012131)2.40339438
32Panhypogammaglobulinemia (HP:0003139)2.35115769
33Vertebral arch anomaly (HP:0008438)2.31771296
34Aplasia/Hypoplasia of the patella (HP:0006498)2.30806198
35High pitched voice (HP:0001620)2.30527953
36Chromosomal breakage induced by crosslinking agents (HP:0003221)2.29627095
37Proximal placement of thumb (HP:0009623)2.25580232
38Turricephaly (HP:0000262)2.23988722
39Recurrent viral infections (HP:0004429)2.21065813
40Broad distal phalanx of finger (HP:0009836)2.20959728
41Thin ribs (HP:0000883)2.20149178
42Increased density of long bones (HP:0006392)2.19901162
43Protrusio acetabuli (HP:0003179)2.19145082
44Deviation of the thumb (HP:0009603)2.17035938
45Skull defect (HP:0001362)2.16944165
46Small epiphyses (HP:0010585)2.14984350
47Recurrent bronchitis (HP:0002837)2.14666268
48Broad face (HP:0000283)2.14101025
49Skin tags (HP:0010609)2.13637727
50Thyroiditis (HP:0100646)2.13507071
51Atresia of the external auditory canal (HP:0000413)2.11092672
52Pointed chin (HP:0000307)2.07869642
53Abnormality of the distal phalanx of the thumb (HP:0009617)2.07539378
54Broad palm (HP:0001169)2.04875523
55Cutis marmorata (HP:0000965)2.04603069
56Arnold-Chiari malformation (HP:0002308)2.02903468
57Patellar dislocation (HP:0002999)1.99372786
58Renovascular hypertension (HP:0100817)1.99179666
59Chromsome breakage (HP:0040012)1.99012696
60Urethral obstruction (HP:0000796)1.97659516
61Short 5th finger (HP:0009237)1.97567424
62Neoplasm of striated muscle (HP:0009728)1.97057162
63Shallow orbits (HP:0000586)1.96255887
64Volvulus (HP:0002580)1.96056802
65Hypoplasia of the capital femoral epiphysis (HP:0003090)1.94782233
66Metaphyseal cupping (HP:0003021)1.94632908
67Limited elbow extension (HP:0001377)1.94402574
68Combined immunodeficiency (HP:0005387)1.93351753
69Overriding aorta (HP:0002623)1.93311590
70Abnormality of reticulocytes (HP:0004312)1.93192351
71Bowel diverticulosis (HP:0005222)1.92439976
72Overlapping toe (HP:0001845)1.91627040
73Premature rupture of membranes (HP:0001788)1.89735991
74Gastrointestinal inflammation (HP:0004386)1.88713492
75Elfin facies (HP:0004428)1.88493744
76Ankle contracture (HP:0006466)1.87819113
77Preauricular skin tag (HP:0000384)1.85984511
78Duplication of thumb phalanx (HP:0009942)1.85722946
7911 pairs of ribs (HP:0000878)1.83571832
80Partial duplication of thumb phalanx (HP:0009944)1.83266658
81Supernumerary ribs (HP:0005815)1.83142276
82Broad phalanges of the hand (HP:0009768)1.82483802
83Hallux valgus (HP:0001822)1.82085619
84Colitis (HP:0002583)1.81717582
85Cerebral aneurysm (HP:0004944)1.81618678
86Trigonocephaly (HP:0000243)1.80764734
87Deviation of the hallux (HP:0010051)1.80692722
88Abnormality of the phalanges of the hallux (HP:0010057)1.79794627
89Partial duplication of the phalanx of hand (HP:0009999)1.78551175
90Acute lymphatic leukemia (HP:0006721)1.78489585
91Neoplasm of the oral cavity (HP:0100649)1.78172070
92Insomnia (HP:0100785)1.77717338
93Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.77687956
94Bicuspid aortic valve (HP:0001647)1.77342789
95Rib fusion (HP:0000902)1.77068787
96Rhabdomyosarcoma (HP:0002859)1.76934017
97Obsessive-compulsive behavior (HP:0000722)1.75049475
98Trismus (HP:0000211)1.74877331
99Biconcave vertebral bodies (HP:0004586)1.74652021
100Gastrointestinal carcinoma (HP:0002672)1.73649963
101Malignant gastrointestinal tract tumors (HP:0006749)1.73649963
102Severe combined immunodeficiency (HP:0004430)1.73421106
103Uterine leiomyosarcoma (HP:0002891)1.72851768
104Leiomyosarcoma (HP:0100243)1.72851768
105Abnormality of oral frenula (HP:0000190)1.72821604
106IgM deficiency (HP:0002850)1.72621668
107Abnormality of the astrocytes (HP:0100707)1.72171018
108Astrocytoma (HP:0009592)1.72171018
109Broad thumb (HP:0011304)1.72148437
110Ectopic kidney (HP:0000086)1.71608415
111Pseudobulbar signs (HP:0002200)1.71068490
112Broad finger (HP:0001500)1.70904010
113Spina bifida occulta (HP:0003298)1.70646801
114Abnormality of the calcaneus (HP:0008364)1.69654083
115Supernumerary bones of the axial skeleton (HP:0009144)1.69617993
116Flat cornea (HP:0007720)1.68555445
117Reticulocytosis (HP:0001923)1.68476986
118Breast hypoplasia (HP:0003187)1.68447136
119Genu recurvatum (HP:0002816)1.68143563
120T lymphocytopenia (HP:0005403)1.67831554
121Obstructive sleep apnea (HP:0002870)1.67321373
122Flared metaphyses (HP:0003015)1.67126203
123Bronchomalacia (HP:0002780)1.67117198
124Abnormality of the thoracic spine (HP:0100711)1.67028201
125Bowing of the arm (HP:0006488)1.66378987
126Bowed forearm bones (HP:0003956)1.66378987
127Short phalanx of the thumb (HP:0009660)1.66006922
128Ankyloglossia (HP:0010296)1.64997403
129Achilles tendon contracture (HP:0001771)1.64513212
130Missing ribs (HP:0000921)1.63895451
131Inflammation of the large intestine (HP:0002037)1.63352446
132Thrombocytosis (HP:0001894)1.63028565
133Neoplasm of the pancreas (HP:0002894)1.62842638
134Bladder diverticulum (HP:0000015)1.62530280
135Nephroblastoma (Wilms tumor) (HP:0002667)1.62507871
136Abnormality of the aortic arch (HP:0012303)1.62430081
137Cortical dysplasia (HP:0002539)1.62346068
138Abnormality of chromosome segregation (HP:0002916)1.61940665
139Facial hemangioma (HP:0000329)1.61180984
140Spinal cord lesions (HP:0100561)1.60931639
141Syringomyelia (HP:0003396)1.60931639
142Premature skin wrinkling (HP:0100678)1.60172518
143Squamous cell carcinoma (HP:0002860)1.60007542
144Adenoma sebaceum (HP:0009720)1.59949468
145Angiofibromas (HP:0010615)1.59949468
146Aplasia/Hypoplasia of the sacrum (HP:0008517)1.59262791
147Pallor (HP:0000980)1.58600652
148Truncus arteriosus (HP:0001660)1.58113980
149Cafe-au-lait spot (HP:0000957)1.57754129
150Vertebral clefting (HP:0008428)1.57727321
151Dislocated radial head (HP:0003083)1.57406224
152Viral hepatitis (HP:0006562)1.55868019
153Abnormality of cochlea (HP:0000375)1.55682250
154Heterotopia (HP:0002282)1.54993244
155Abnormality of the parietal bone (HP:0002696)1.54842212
156Abnormal vertebral ossification (HP:0100569)1.54128474
157Midface retrusion (HP:0011800)1.54112854
158Coronal craniosynostosis (HP:0004440)1.52010306
159Megalocornea (HP:0000485)1.51109350

Predicted kinase interactions (KEA)

RankGene SetZ-score
1SMG14.73476369
2EEF2K4.57880890
3CDK123.30833556
4CDC73.21960186
5TRIB33.12712567
6PRPF4B3.01829929
7PKN23.01507877
8NEK22.78769958
9BUB12.44498855
10GRK62.25211325
11MAP4K12.23730404
12TLK12.18336384
13ERN12.11891102
14STK102.00609211
15RPS6KB21.98327824
16VRK21.74019036
17LRRK21.73950358
18WEE11.71070235
19PASK1.70762766
20STK41.66786540
21FGFR41.65146090
22CDK191.63320856
23* MAP3K101.58680122
24TAF11.55879041
25IRAK31.42373602
26DYRK31.40490757
27CDK71.40341651
28* CDK41.38582703
29TTK1.37084829
30BRD41.35173201
31TGFBR11.34180486
32MAP3K81.32772453
33RPS6KA41.31119200
34PAK41.30027189
35PTK61.29320261
36CDK61.24323503
37MKNK11.21717067
38TESK21.21575757
39SCYL21.19438619
40CLK11.18104905
41ATR1.16859453
42ICK1.15917622
43BTK1.13866125
44PIM11.11956472
45SIK21.08379243
46CDK81.08166435
47MKNK21.05194524
48AURKB1.04969966
49MTOR1.04314138
50CHEK11.03423395
51TYRO31.00632772
52CSF1R0.98776415
53PLK10.98702614
54CHEK20.98372113
55BRAF0.93939156
56LATS20.90621439
57SRPK10.89751486
58CDK90.89502365
59SIK10.88839244
60ALK0.88821068
61MAP2K20.86922663
62BLK0.85073778
63TTN0.84157901
64PDGFRA0.83871603
65DYRK1B0.80545633
66FLT30.80274916
67KDR0.79136036
68STK30.78453270
69* CDK20.77879736
70PRKD30.77762974
71ACVR1B0.76698686
72RPS6KL10.73453668
73RPS6KC10.73453668
74MAP2K30.72713726
75MAPK110.71911099
76MELK0.70948744
77BMX0.70878953
78PAK20.70154710
79MAP3K130.70068783
80CAMK1D0.70060312
81TSSK60.69945449
82KSR20.69549827
83ATM0.67786334
84ILK0.65491814
85MARK20.64220279
86ZAP700.62957607
87MAP3K90.62586894
88HIPK20.62094813
89EPHB20.61670890
90CDC42BPA0.61031747
91NME20.60900499
92TAOK20.59860971
93AURKA0.59699103
94PTK20.59555965
95RPS6KA20.59311701
96MAPKAPK30.59182188
97CAMK1G0.58544062
98BRSK10.58256605
99NTRK10.57922186
100SYK0.57492944
101IRAK20.56173450
102IRAK40.53901205
103CDK10.50649093
104AKT20.50321845
105SIK30.49923765
106RPS6KA60.48373503
107BRSK20.46316914
108MAP3K70.44861972
109RIPK10.44339401
110MET0.44144071
111ARAF0.44077199
112CDK11A0.43841281
113TGFBR20.43473490
114FGFR20.42896215
115FGFR30.42591352
116FGFR10.41981208
117HCK0.41434302
118NEK10.40945480
119DMPK0.40641791
120JAK30.40211115
121EPHA20.40198750
122PLK40.39840435
123PRKD20.39458020
124MAPKAPK20.39442829
125CHUK0.38786549
126CSNK1D0.38637813
127RPS6KA10.37962606
128LYN0.37932766
129AKT10.37771509
130TAOK10.36792710
131PAK10.36634742
132MARK30.36078656
133ITK0.34627049
134PRKDC0.34564065
135CSNK2A20.33111862

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.11573009
2Mismatch repair_Homo sapiens_hsa034303.32008568
3Spliceosome_Homo sapiens_hsa030402.99239151
4Base excision repair_Homo sapiens_hsa034102.95842644
5Cell cycle_Homo sapiens_hsa041102.64358395
6Ribosome_Homo sapiens_hsa030102.63506145
7Primary immunodeficiency_Homo sapiens_hsa053402.31810152
8RNA transport_Homo sapiens_hsa030132.30400801
9Non-homologous end-joining_Homo sapiens_hsa034502.04890744
10mRNA surveillance pathway_Homo sapiens_hsa030152.02648044
11Homologous recombination_Homo sapiens_hsa034401.98505433
12Nucleotide excision repair_Homo sapiens_hsa034201.89910717
13B cell receptor signaling pathway_Homo sapiens_hsa046621.84160619
14One carbon pool by folate_Homo sapiens_hsa006701.83523984
15Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.76611878
16Chronic myeloid leukemia_Homo sapiens_hsa052201.71691401
17Systemic lupus erythematosus_Homo sapiens_hsa053221.69562648
18Notch signaling pathway_Homo sapiens_hsa043301.54328262
19Basal cell carcinoma_Homo sapiens_hsa052171.53706886
20MicroRNAs in cancer_Homo sapiens_hsa052061.51129399
21Viral carcinogenesis_Homo sapiens_hsa052031.47992039
22Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.46994235
23p53 signaling pathway_Homo sapiens_hsa041151.46958650
24Small cell lung cancer_Homo sapiens_hsa052221.41723313
25Fanconi anemia pathway_Homo sapiens_hsa034601.39638519
26Biosynthesis of amino acids_Homo sapiens_hsa012301.36873426
27* HTLV-I infection_Homo sapiens_hsa051661.36542252
28Non-small cell lung cancer_Homo sapiens_hsa052231.29887362
29RNA degradation_Homo sapiens_hsa030181.27172498
30Herpes simplex infection_Homo sapiens_hsa051681.22288492
31Colorectal cancer_Homo sapiens_hsa052101.21353125
32* Transcriptional misregulation in cancer_Homo sapiens_hsa052021.21171151
33Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.19709910
34Epstein-Barr virus infection_Homo sapiens_hsa051691.15151599
35Pyrimidine metabolism_Homo sapiens_hsa002401.14519134
36Antigen processing and presentation_Homo sapiens_hsa046121.11604886
37Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.11310561
38Lysine degradation_Homo sapiens_hsa003101.09985142
39Bladder cancer_Homo sapiens_hsa052191.06295185
40Acute myeloid leukemia_Homo sapiens_hsa052211.06186948
41Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.05483401
42Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.05191939
43Hedgehog signaling pathway_Homo sapiens_hsa043401.03925210
44ErbB signaling pathway_Homo sapiens_hsa040121.03299080
45Hippo signaling pathway_Homo sapiens_hsa043901.00996853
46Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.00882088
47Pancreatic cancer_Homo sapiens_hsa052121.00024234
48Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.96050379
49Thyroid cancer_Homo sapiens_hsa052160.95405207
50RNA polymerase_Homo sapiens_hsa030200.92982999
51NF-kappa B signaling pathway_Homo sapiens_hsa040640.92509103
52Hepatitis B_Homo sapiens_hsa051610.92021102
53Proteoglycans in cancer_Homo sapiens_hsa052050.91842021
54Longevity regulating pathway - mammal_Homo sapiens_hsa042110.89054064
55Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.88600675
56* Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.86982999
57Apoptosis_Homo sapiens_hsa042100.85909776
58Alcoholism_Homo sapiens_hsa050340.85836979
59Viral myocarditis_Homo sapiens_hsa054160.84724661
60Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.84722426
61mTOR signaling pathway_Homo sapiens_hsa041500.84558720
62Adherens junction_Homo sapiens_hsa045200.82655957
63Insulin signaling pathway_Homo sapiens_hsa049100.81581248
64Pathways in cancer_Homo sapiens_hsa052000.81378929
65Leukocyte transendothelial migration_Homo sapiens_hsa046700.81020907
66AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.79586798
67Prostate cancer_Homo sapiens_hsa052150.79210822
68Shigellosis_Homo sapiens_hsa051310.78603506
69Endometrial cancer_Homo sapiens_hsa052130.78024620
70Central carbon metabolism in cancer_Homo sapiens_hsa052300.77487224
71AMPK signaling pathway_Homo sapiens_hsa041520.75576686
72Measles_Homo sapiens_hsa051620.74786744
73Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.74752718
74Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.73653289
75Neurotrophin signaling pathway_Homo sapiens_hsa047220.73336946
76T cell receptor signaling pathway_Homo sapiens_hsa046600.71729302
77Glioma_Homo sapiens_hsa052140.70603229
78Oocyte meiosis_Homo sapiens_hsa041140.70396895
79Melanogenesis_Homo sapiens_hsa049160.69449164
80TGF-beta signaling pathway_Homo sapiens_hsa043500.69110533
81VEGF signaling pathway_Homo sapiens_hsa043700.69100902
82Thyroid hormone signaling pathway_Homo sapiens_hsa049190.68830368
83Fructose and mannose metabolism_Homo sapiens_hsa000510.68442579
84Basal transcription factors_Homo sapiens_hsa030220.67874414
85Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.67329444
86Choline metabolism in cancer_Homo sapiens_hsa052310.65275029
87Prion diseases_Homo sapiens_hsa050200.64203964
88Wnt signaling pathway_Homo sapiens_hsa043100.63461858
892-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.61891396
90Focal adhesion_Homo sapiens_hsa045100.61708898
91Leishmaniasis_Homo sapiens_hsa051400.60969368
92Toxoplasmosis_Homo sapiens_hsa051450.60935608
93Platelet activation_Homo sapiens_hsa046110.60531519
94Hematopoietic cell lineage_Homo sapiens_hsa046400.59948056
95Osteoclast differentiation_Homo sapiens_hsa043800.59870266
96FoxO signaling pathway_Homo sapiens_hsa040680.59096615
97N-Glycan biosynthesis_Homo sapiens_hsa005100.58828236
98Intestinal immune network for IgA production_Homo sapiens_hsa046720.56967073
99Carbon metabolism_Homo sapiens_hsa012000.56476198
100Sulfur relay system_Homo sapiens_hsa041220.56308677
101Prolactin signaling pathway_Homo sapiens_hsa049170.56113238
102Phospholipase D signaling pathway_Homo sapiens_hsa040720.55444685
103Inositol phosphate metabolism_Homo sapiens_hsa005620.52452660
104Axon guidance_Homo sapiens_hsa043600.51684481
105Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.51597539
106Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.50409499
107HIF-1 signaling pathway_Homo sapiens_hsa040660.50223042
108Estrogen signaling pathway_Homo sapiens_hsa049150.48698324
109Renin-angiotensin system_Homo sapiens_hsa046140.47479063
110Hepatitis C_Homo sapiens_hsa051600.45729553
111Renal cell carcinoma_Homo sapiens_hsa052110.45162523
112Influenza A_Homo sapiens_hsa051640.44737646
113Galactose metabolism_Homo sapiens_hsa000520.44613478
114PI3K-Akt signaling pathway_Homo sapiens_hsa041510.44452834
115Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.43269767
116Legionellosis_Homo sapiens_hsa051340.42620541
117Jak-STAT signaling pathway_Homo sapiens_hsa046300.41903580
118Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.40273310
119Melanoma_Homo sapiens_hsa052180.39277968
120Selenocompound metabolism_Homo sapiens_hsa004500.39118666
121Regulation of actin cytoskeleton_Homo sapiens_hsa048100.38499050
122Cyanoamino acid metabolism_Homo sapiens_hsa004600.37934703
123Pentose phosphate pathway_Homo sapiens_hsa000300.36979168
124ECM-receptor interaction_Homo sapiens_hsa045120.36978585

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