TCF15

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is found in the nucleus and may be involved in the early transcriptional regulation of patterning of the mesoderm. The encoded basic helix-loop-helix protein requires dimerization with another basic helix-loop-helix protein for efficient DNA binding. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of gene silencing by miRNA (GO:0060964)6.41952348
2regulation of gene silencing by RNA (GO:0060966)6.41952348
3regulation of posttranscriptional gene silencing (GO:0060147)6.41952348
4mitochondrial ATP synthesis coupled proton transport (GO:0042776)6.40064768
5chaperone-mediated protein transport (GO:0072321)6.09265365
6mitochondrial electron transport, NADH to ubiquinone (GO:0006120)5.87985758
7ATP synthesis coupled proton transport (GO:0015986)5.53303020
8energy coupled proton transport, down electrochemical gradient (GO:0015985)5.53303020
9respiratory electron transport chain (GO:0022904)5.32918503
10termination of RNA polymerase III transcription (GO:0006386)5.27898844
11transcription elongation from RNA polymerase III promoter (GO:0006385)5.27898844
12maturation of SSU-rRNA (GO:0030490)5.22596064
13electron transport chain (GO:0022900)5.16323147
14ribosomal small subunit assembly (GO:0000028)5.04952967
15viral transcription (GO:0019083)4.77022883
16translational termination (GO:0006415)4.67160631
17ribosomal small subunit biogenesis (GO:0042274)4.52623264
18formation of translation preinitiation complex (GO:0001731)4.41282540
19DNA replication-dependent nucleosome assembly (GO:0006335)4.41183053
20DNA replication-dependent nucleosome organization (GO:0034723)4.41183053
21DNA replication initiation (GO:0006270)4.38263815
22protein targeting to mitochondrion (GO:0006626)4.33841183
23translational elongation (GO:0006414)4.27436730
24DNA deamination (GO:0045006)4.11808192
25ribosome biogenesis (GO:0042254)4.09157988
26somatic hypermutation of immunoglobulin genes (GO:0016446)4.06354522
27somatic diversification of immune receptors via somatic mutation (GO:0002566)4.06354522
28CENP-A containing nucleosome assembly (GO:0034080)4.05830714
29translational initiation (GO:0006413)4.04699256
30ribonucleoprotein complex biogenesis (GO:0022613)4.01370863
31proteasome assembly (GO:0043248)4.01123293
32regulation of helicase activity (GO:0051095)4.00160620
33pyrimidine deoxyribonucleotide catabolic process (GO:0009223)4.00075188
34establishment of protein localization to mitochondrion (GO:0072655)4.00027419
35IMP biosynthetic process (GO:0006188)3.96800471
36nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.92458751
37positive regulation of SMAD protein import into nucleus (GO:0060391)3.83910750
38DNA unwinding involved in DNA replication (GO:0006268)3.83555819
39protein localization to mitochondrion (GO:0070585)3.82203702
40DNA strand elongation involved in DNA replication (GO:0006271)3.78625334
41nucleobase biosynthetic process (GO:0046112)3.78316479
42regulation of mitochondrial translation (GO:0070129)3.68134041
43mitochondrial respiratory chain complex I assembly (GO:0032981)3.66463152
44NADH dehydrogenase complex assembly (GO:0010257)3.66463152
45mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.66463152
46DNA strand elongation (GO:0022616)3.64063727
47protein complex biogenesis (GO:0070271)3.64054029
48regulation of gene silencing (GO:0060968)3.63023054
49ribosomal large subunit biogenesis (GO:0042273)3.62378694
50cellular protein complex disassembly (GO:0043624)3.61800619
51folic acid-containing compound biosynthetic process (GO:0009396)3.60374297
52nodal signaling pathway (GO:0038092)3.60363331
53pre-miRNA processing (GO:0031054)3.57210390
54mitochondrial respiratory chain complex assembly (GO:0033108)3.57091602
55regulation of histone H3-K9 methylation (GO:0051570)3.55229810
56histone exchange (GO:0043486)3.55086640
57oxidative phosphorylation (GO:0006119)3.55041899
58IMP metabolic process (GO:0046040)3.54900391
59protein targeting to membrane (GO:0006612)3.52151365
60rRNA processing (GO:0006364)3.50913813
61telomere maintenance via semi-conservative replication (GO:0032201)3.50553148
62viral life cycle (GO:0019058)3.49716678
63SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.48903969
64purine nucleobase biosynthetic process (GO:0009113)3.46641545
65protein K6-linked ubiquitination (GO:0085020)3.44781632
66pyrimidine nucleotide catabolic process (GO:0006244)3.44447719
67ATP biosynthetic process (GO:0006754)3.42721818
68regulation of nuclear cell cycle DNA replication (GO:0033262)3.39934815
69protein targeting to ER (GO:0045047)3.39103006
70histone arginine methylation (GO:0034969)3.38856673
71regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.38784419
72regulation of mitotic spindle checkpoint (GO:1903504)3.38784419
73nuclear pore organization (GO:0006999)3.37762826
74rRNA metabolic process (GO:0016072)3.37643601
75intracellular protein transmembrane import (GO:0044743)3.37527644
76cotranslational protein targeting to membrane (GO:0006613)3.37397131
77heterochromatin organization (GO:0070828)3.37336640
78base-excision repair, AP site formation (GO:0006285)3.36137520
79protein complex disassembly (GO:0043241)3.35449768
80protein-cofactor linkage (GO:0018065)3.35176521
81DNA replication-independent nucleosome organization (GO:0034724)3.34907592
82DNA replication-independent nucleosome assembly (GO:0006336)3.34907592
83protein transmembrane transport (GO:0071806)3.32817570
84negative regulation of gene silencing (GO:0060969)3.32355408
85mitotic metaphase plate congression (GO:0007080)3.32254990
86mitotic nuclear envelope disassembly (GO:0007077)3.29067193
87histone H4-K12 acetylation (GO:0043983)3.27499672
88ribosome assembly (GO:0042255)3.27187653
89pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.25998119
90establishment of protein localization to endoplasmic reticulum (GO:0072599)3.24656976
91negative regulation of retinoic acid receptor signaling pathway (GO:0048387)3.22962875
92transcription from RNA polymerase III promoter (GO:0006383)3.22893650
93regulation of translational fidelity (GO:0006450)3.21711884
94mitochondrial transport (GO:0006839)3.21076243
95DNA replication checkpoint (GO:0000076)3.19095412
96regulation of SMAD protein import into nucleus (GO:0060390)3.18316069
97determination of adult lifespan (GO:0008340)3.15899300
98intracellular protein transmembrane transport (GO:0065002)3.12898210
99protein localization to endoplasmic reticulum (GO:0070972)3.12841509
100macromolecular complex disassembly (GO:0032984)3.12339702
101establishment of protein localization to mitochondrial membrane (GO:0090151)3.12281391
102kinetochore assembly (GO:0051382)3.11939357
103spliceosomal snRNP assembly (GO:0000387)3.11644847
104negative regulation of histone methylation (GO:0031061)3.10241555
105purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.10137350
106histone mRNA metabolic process (GO:0008334)3.06367277
107purine nucleoside triphosphate biosynthetic process (GO:0009145)3.04325434
108nuclear envelope disassembly (GO:0051081)3.03226810
109membrane disassembly (GO:0030397)3.03226810
110inner mitochondrial membrane organization (GO:0007007)3.02939330
111hydrogen ion transmembrane transport (GO:1902600)3.02789378
112apoptotic process involved in morphogenesis (GO:0060561)3.02342809
113ncRNA 3-end processing (GO:0043628)3.01580834
114peptidyl-arginine omega-N-methylation (GO:0035247)3.01124403
115nuclear-transcribed mRNA catabolic process (GO:0000956)3.00394250
116ribonucleoside triphosphate biosynthetic process (GO:0009201)2.96554224
117anterior/posterior axis specification, embryo (GO:0008595)2.96539879
118mitotic sister chromatid segregation (GO:0000070)2.94888651
119mitochondrial RNA metabolic process (GO:0000959)2.94525458
120regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.93306501
121telomere maintenance via telomere lengthening (GO:0010833)2.92541578
122transcription from mitochondrial promoter (GO:0006390)2.92180017
123establishment of integrated proviral latency (GO:0075713)2.90503707
124DNA duplex unwinding (GO:0032508)2.89729999
125nucleotide-excision repair, DNA gap filling (GO:0006297)2.89692991
126regulation of translational termination (GO:0006449)2.89243507
127kinetochore organization (GO:0051383)2.89128119
128DNA geometric change (GO:0032392)2.88913880
129telomere maintenance via recombination (GO:0000722)2.87423346
130nuclear pore complex assembly (GO:0051292)2.86376949
131chromatin remodeling at centromere (GO:0031055)2.86278691
132respiratory chain complex IV assembly (GO:0008535)2.86125493
133RNA catabolic process (GO:0006401)2.85576234
134mRNA catabolic process (GO:0006402)2.85247908
135nucleoside triphosphate biosynthetic process (GO:0009142)2.84670945
136protein localization to kinetochore (GO:0034501)2.84452140
137translation (GO:0006412)2.83331299
138spliceosomal complex assembly (GO:0000245)2.82663821
139cellular component biogenesis (GO:0044085)2.82607438
140ventricular cardiac muscle cell development (GO:0055015)2.82368544
141purine ribonucleoside monophosphate biosynthetic process (GO:0009168)2.81358430
142purine nucleoside monophosphate biosynthetic process (GO:0009127)2.81358430
143cytochrome complex assembly (GO:0017004)2.81140748
144spliceosomal tri-snRNP complex assembly (GO:0000244)2.80141588
145DNA-templated transcription, termination (GO:0006353)2.79376878
146embryonic process involved in female pregnancy (GO:0060136)2.78845223
147regulation of mitotic spindle organization (GO:0060236)2.78708745
148protein neddylation (GO:0045116)2.77421995
149metaphase plate congression (GO:0051310)2.76951524
150rRNA modification (GO:0000154)2.76653818
151protein localization to chromosome, centromeric region (GO:0071459)2.76221365
152mitotic G1 DNA damage checkpoint (GO:0031571)2.75897801
153chromatin assembly (GO:0031497)2.75430296
154pseudouridine synthesis (GO:0001522)2.75183860
155dosage compensation (GO:0007549)2.74285390
156aerobic respiration (GO:0009060)2.71567276

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.76515079
2* MYC_18555785_ChIP-Seq_MESCs_Mouse4.15926124
3SMAD1_18555785_ChIP-Seq_MESCs_Mouse3.36266083
4MYC_19079543_ChIP-ChIP_MESCs_Mouse3.35781003
5EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.16818629
6* KLF5_18264089_ChIP-ChIP_MESCs_Mouse3.09664792
7* KLF4_18264089_ChIP-ChIP_MESCs_Mouse3.09664792
8* KLF2_18264089_ChIP-ChIP_MESCs_Mouse3.09664792
9POU5F1_18700969_ChIP-ChIP_MESCs_Mouse3.00266918
10FOXM1_23109430_ChIP-Seq_U2OS_Human2.95773079
11MYC_19030024_ChIP-ChIP_MESCs_Mouse2.72759641
12MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.66884676
13E2F4_17652178_ChIP-ChIP_JURKAT_Human2.62599591
14* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.57260933
15NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.52350507
16NANOG_18555785_ChIP-Seq_MESCs_Mouse2.50688536
17NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.46992194
18STAT3_1855785_ChIP-Seq_MESCs_Mouse2.43437359
19FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.27158576
20POU5F1_18358816_ChIP-ChIP_MESCs_Mouse2.22455264
21TCF3_18692474_ChIP-Seq_MEFs_Mouse2.21854937
22NELFA_20434984_ChIP-Seq_ESCs_Mouse2.15080188
23ETS1_20019798_ChIP-Seq_JURKAT_Human2.13690660
24SOX2_18555785_ChIP-Seq_MESCs_Mouse2.07866558
25EST1_17652178_ChIP-ChIP_JURKAT_Human2.04402352
26ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.04389069
27SOX2_18358816_ChIP-ChIP_MESCs_Mouse2.02028544
28JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.01961663
29CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.01422891
30XRN2_22483619_ChIP-Seq_HELA_Human1.97995734
31POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.97099927
32E2F1_18555785_ChIP-Seq_MESCs_Mouse1.94985945
33SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.90796785
34MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.89612187
35HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.88147139
36PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.87592306
37TCF3_18692474_ChIP-Seq_MESCs_Mouse1.86383317
38ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.83636299
39* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.83591645
40SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.81472380
41KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.77140746
42PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.76218301
43CREB1_15753290_ChIP-ChIP_HEK293T_Human1.74668080
44SRF_21415370_ChIP-Seq_HL-1_Mouse1.73451134
45ZNF263_19887448_ChIP-Seq_K562_Human1.71597068
46E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.69291115
47KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.69013459
48GABP_17652178_ChIP-ChIP_JURKAT_Human1.66371988
49NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.64361917
50ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.64269762
51ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.62083962
52* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.60325128
53* SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.59881173
54SOX2_18692474_ChIP-Seq_MEFs_Mouse1.57541295
55YY1_21170310_ChIP-Seq_MESCs_Mouse1.52765593
56ELK1_19687146_ChIP-ChIP_HELA_Human1.49834883
57THAP11_20581084_ChIP-Seq_MESCs_Mouse1.48929458
58MYC_22102868_ChIP-Seq_BL_Human1.48075532
59KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.47705326
60RBPJ_22232070_ChIP-Seq_NCS_Mouse1.47429435
61E2F1_21310950_ChIP-Seq_MCF-7_Human1.44845712
62KLF4_18555785_ChIP-Seq_MESCs_Mouse1.41883388
63VDR_23849224_ChIP-Seq_CD4+_Human1.41801786
64MYC_18940864_ChIP-ChIP_HL60_Human1.41388352
65KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.41092504
66TTF2_22483619_ChIP-Seq_HELA_Human1.40694222
67OCT4_18692474_ChIP-Seq_MEFs_Mouse1.39732422
68POU5F1_16518401_ChIP-PET_MESCs_Mouse1.38452908
69MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.38385936
70SOX2_18692474_ChIP-Seq_MESCs_Mouse1.37372481
71CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.37326110
72DCP1A_22483619_ChIP-Seq_HELA_Human1.36597380
73TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.32363593
74NANOG_18692474_ChIP-Seq_MEFs_Mouse1.30600027
75SOX2_16153702_ChIP-ChIP_HESCs_Human1.29997418
76TP63_19390658_ChIP-ChIP_HaCaT_Human1.29721216
77GABP_19822575_ChIP-Seq_HepG2_Human1.28916684
78* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.28130317
79ESR1_15608294_ChIP-ChIP_MCF-7_Human1.26995384
80NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.26555610
81NANOG_16153702_ChIP-ChIP_HESCs_Human1.25479081
82POU5F1_16153702_ChIP-ChIP_HESCs_Human1.25288048
83SALL1_21062744_ChIP-ChIP_HESCs_Human1.25229115
84CIITA_25753668_ChIP-Seq_RAJI_Human1.24363149
85FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.23403200
86AR_21909140_ChIP-Seq_LNCAP_Human1.21693665
87NANOG_21062744_ChIP-ChIP_HESCs_Human1.21354102
88FOXP3_21729870_ChIP-Seq_TREG_Human1.20785564
89POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.20493024
90EGR1_19374776_ChIP-ChIP_THP-1_Human1.17390065
91TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.15471407
92CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.13785381
93DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.13187093
94NANOG_18692474_ChIP-Seq_MESCs_Mouse1.12756083
95FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.08558683
96CTCF_18555785_ChIP-Seq_MESCs_Mouse1.08544185
97NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.08382396
98YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.07936439
99HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.06712434
100BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.04180120
101ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.01393213
102SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.98701898
103KAP1_27257070_Chip-Seq_ESCs_Mouse0.98695018
104TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.98104720
105E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.97757213
106KDM5A_27292631_Chip-Seq_BREAST_Human0.95909627
107CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.95482259
108SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.95173375
109* TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.93970434
110ZFP281_18757296_ChIP-ChIP_E14_Mouse0.93310138
111* TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.93233707
112FOXP1_21924763_ChIP-Seq_HESCs_Human0.92197478
113VDR_21846776_ChIP-Seq_THP-1_Human0.92173527
114SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.91295303
115VDR_22108803_ChIP-Seq_LS180_Human0.90013075
116HOXB4_20404135_ChIP-ChIP_EML_Mouse0.89881322
117PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.89770527
118ERG_20887958_ChIP-Seq_HPC-7_Mouse0.89673707
119HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.88669676
120TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.86549770
121HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.86469737
122* SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.85572270
123TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.85514965
124SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.84944749
125POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.84619798
126CTCF_26484167_Chip-Seq_Bcells_Mouse0.84216016
127NOTCH1_21737748_ChIP-Seq_TLL_Human0.84082685
128EZH2_22144423_ChIP-Seq_EOC_Human0.82884661
129CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.77074667

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation4.78579012
2MP0008057_abnormal_DNA_replication3.84328512
3MP0004957_abnormal_blastocyst_morpholog3.79115634
4MP0003693_abnormal_embryo_hatching3.50664466
5MP0010094_abnormal_chromosome_stability3.30162566
6MP0003111_abnormal_nucleus_morphology3.28132275
7MP0003077_abnormal_cell_cycle2.90563492
8MP0004133_heterotaxia2.87114380
9MP0008058_abnormal_DNA_repair2.62157431
10MP0003646_muscle_fatigue2.50877629
11MP0004084_abnormal_cardiac_muscle2.33197434
12MP0010368_abnormal_lymphatic_system2.31660538
13MP0003806_abnormal_nucleotide_metabolis2.17505304
14MP0009697_abnormal_copulation2.13787295
15MP0002277_abnormal_respiratory_mucosa2.13774011
16MP0003123_paternal_imprinting2.05474074
17MP0003567_abnormal_fetal_cardiomyocyte2.02933570
18MP0001730_embryonic_growth_arrest1.98780579
19MP0000751_myopathy1.95689260
20MP0003283_abnormal_digestive_organ1.95150657
21MP0010352_gastrointestinal_tract_polyps1.91484706
22MP0008932_abnormal_embryonic_tissue1.91259513
23MP0001672_abnormal_embryogenesis/_devel1.87870189
24MP0005380_embryogenesis_phenotype1.87870189
25* MP0003941_abnormal_skin_development1.86353575
26MP0000350_abnormal_cell_proliferation1.85502441
27MP0002653_abnormal_ependyma_morphology1.80465868
28MP0003119_abnormal_digestive_system1.79180034
29MP0004197_abnormal_fetal_growth/weight/1.78851007
30MP0002086_abnormal_extraembryonic_tissu1.78485156
31MP0000750_abnormal_muscle_regeneration1.78110356
32* MP0002085_abnormal_embryonic_tissue1.76419237
33MP0000049_abnormal_middle_ear1.75563680
34* MP0002084_abnormal_developmental_patter1.75038606
35MP0001697_abnormal_embryo_size1.73612749
36MP0003984_embryonic_growth_retardation1.71031620
37MP0004272_abnormal_basement_membrane1.68157426
38MP0002088_abnormal_embryonic_growth/wei1.67236602
39MP0010030_abnormal_orbit_morphology1.61818665
40MP0008007_abnormal_cellular_replicative1.61178844
41MP0003705_abnormal_hypodermis_morpholog1.59408607
42MP0003828_pulmonary_edema1.57855605
43MP0002080_prenatal_lethality1.54357865
44MP0005330_cardiomyopathy1.54346281
45MP0002269_muscular_atrophy1.49636743
46MP0002127_abnormal_cardiovascular_syste1.46467675
47MP0003136_yellow_coat_color1.45241113
48MP0003786_premature_aging1.43542817
49MP0006035_abnormal_mitochondrial_morpho1.41484838
50MP0001188_hyperpigmentation1.41105720
51MP0001879_abnormal_lymphatic_vessel1.40986710
52MP0003718_maternal_effect1.40305980
53MP0003186_abnormal_redox_activity1.39563265
54MP0004215_abnormal_myocardial_fiber1.37955954
55MP0003566_abnormal_cell_adhesion1.35068460
56MP0000372_irregular_coat_pigmentation1.34794840
57MP0001293_anophthalmia1.33242858
58MP0006292_abnormal_olfactory_placode1.32892014
59MP0002160_abnormal_reproductive_system1.30982018
60MP0008995_early_reproductive_senescence1.29693857
61MP0010630_abnormal_cardiac_muscle1.29519866
62MP0004145_abnormal_muscle_electrophysio1.27847907
63MP0008877_abnormal_DNA_methylation1.27743894
64MP0009278_abnormal_bone_marrow1.26521755
65MP0002796_impaired_skin_barrier1.26060553
66MP0002837_dystrophic_cardiac_calcinosis1.22972731
67MP0005623_abnormal_meninges_morphology1.22536809
68MP0002396_abnormal_hematopoietic_system1.21979267
69MP0002332_abnormal_exercise_endurance1.21355815
70MP0010307_abnormal_tumor_latency1.20077964
71MP0005266_abnormal_metabolism1.19678009
72MP0002249_abnormal_larynx_morphology1.17961794
73MP0005670_abnormal_white_adipose1.17660199
74MP0002106_abnormal_muscle_physiology1.17641074
75MP0003950_abnormal_plasma_membrane1.16708398
76MP0008789_abnormal_olfactory_epithelium1.16024029
77MP0003221_abnormal_cardiomyocyte_apopto1.14519783
78MP0003890_abnormal_embryonic-extraembry1.14004548
79MP0000490_abnormal_crypts_of1.13404674
80MP0000678_abnormal_parathyroid_gland1.12810417
81MP0000313_abnormal_cell_death1.11371488
82MP0004036_abnormal_muscle_relaxation1.10641624
83MP0004087_abnormal_muscle_fiber1.10413849
84MP0008775_abnormal_heart_ventricle1.10188747
85MP0000631_abnormal_neuroendocrine_gland1.10054488
86MP0001529_abnormal_vocalization1.08567514
87MP0009672_abnormal_birth_weight1.06950010
88MP0000749_muscle_degeneration1.06239312
89MP0003937_abnormal_limbs/digits/tail_de1.05809701
90MP0004233_abnormal_muscle_weight1.05623753
91MP0005666_abnormal_adipose_tissue1.04843535
92MP0005620_abnormal_muscle_contractility1.02682501
93MP0005385_cardiovascular_system_phenoty1.00551345
94MP0001544_abnormal_cardiovascular_syste1.00551345
95MP0004185_abnormal_adipocyte_glucose1.00482416
96MP0002019_abnormal_tumor_incidence1.00105377
97MP0002254_reproductive_system_inflammat0.99787983
98MP0002972_abnormal_cardiac_muscle0.99522566
99MP0006036_abnormal_mitochondrial_physio0.99521001
100MP0003938_abnormal_ear_development0.99176589
101MP0002938_white_spotting0.99132749
102MP0002210_abnormal_sex_determination0.97327794
103MP0002925_abnormal_cardiovascular_devel0.97326175
104MP0003137_abnormal_impulse_conducting0.96933715
105MP0001485_abnormal_pinna_reflex0.96707459
106MP0004130_abnormal_muscle_cell0.96303582
107MP0000266_abnormal_heart_morphology0.95060503
108* MP0002111_abnormal_tail_morphology0.93724040
109MP0005647_abnormal_sex_gland0.91858902
110MP0001545_abnormal_hematopoietic_system0.91691525
111MP0005397_hematopoietic_system_phenotyp0.91691525
112MP0001849_ear_inflammation0.91680833
113MP0002108_abnormal_muscle_morphology0.91623273
114MP0001145_abnormal_male_reproductive0.91508791
115MP0003121_genomic_imprinting0.90594390
116MP0005410_abnormal_fertilization0.88993248
117MP0003315_abnormal_perineum_morphology0.88196273
118MP0004142_abnormal_muscle_tone0.88126858
119MP0005076_abnormal_cell_differentiation0.87670692
120MP0006138_congestive_heart_failure0.87645744
121MP0001929_abnormal_gametogenesis0.87593295
122MP0000762_abnormal_tongue_morphology0.86973730
123MP0005369_muscle_phenotype0.85324071
124MP0000653_abnormal_sex_gland0.84889943
125MP0002163_abnormal_gland_morphology0.83763469
126MP0000747_muscle_weakness0.81600537
127MP0000516_abnormal_urinary_system0.81432593
128MP0005367_renal/urinary_system_phenotyp0.81432593
129MP0000428_abnormal_craniofacial_morphol0.81308176
130MP0004808_abnormal_hematopoietic_stem0.81102018
131MP0005389_reproductive_system_phenotype0.80991295
132MP0002638_abnormal_pupillary_reflex0.78962189
133MP0002697_abnormal_eye_size0.76922051
134MP0004264_abnormal_extraembryonic_tissu0.76359810
135MP0005257_abnormal_intraocular_pressure0.76285862
136* MP0000759_abnormal_skeletal_muscle0.75942818
137MP0008770_decreased_survivor_rate0.73348055
138MP0003942_abnormal_urinary_system0.73099520
139MP0004134_abnormal_chest_morphology0.72743527
140MP0002089_abnormal_postnatal_growth/wei0.71950920
141MP0003698_abnormal_male_reproductive0.71500041
142MP0009250_abnormal_appendicular_skeleto0.69699324
143MP0005023_abnormal_wound_healing0.69484883
144MP0001270_distended_abdomen0.68719282
145MP0001502_abnormal_circadian_rhythm0.68667665
146MP0005501_abnormal_skin_physiology0.67792635
147MP0000358_abnormal_cell_content/0.66839266

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)4.97637163
2Ependymoma (HP:0002888)4.65757233
3Abnormal mitochondria in muscle tissue (HP:0008316)4.51739058
4Nemaline bodies (HP:0003798)4.18842390
5Acute encephalopathy (HP:0006846)4.14051164
6Muscle fiber inclusion bodies (HP:0100299)4.11663020
7Supernumerary spleens (HP:0009799)4.02823951
8Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)4.01602257
9Progressive macrocephaly (HP:0004481)3.97563314
10Mitochondrial inheritance (HP:0001427)3.93930455
11Reticulocytopenia (HP:0001896)3.85880111
12Birth length less than 3rd percentile (HP:0003561)3.72143854
13Increased CSF lactate (HP:0002490)3.61809605
14Breast hypoplasia (HP:0003187)3.59052561
15Rib fusion (HP:0000902)3.55894056
16Increased hepatocellular lipid droplets (HP:0006565)3.50490615
17Abnormality of the labia minora (HP:0012880)3.42695893
18Neoplasm of the oral cavity (HP:0100649)3.42451786
19Abnormality of cells of the erythroid lineage (HP:0012130)3.24340799
20Increased intramyocellular lipid droplets (HP:0012240)3.22924961
21Medulloblastoma (HP:0002885)3.20837498
22Carpal bone hypoplasia (HP:0001498)3.13476057
23Rhabdomyosarcoma (HP:0002859)3.08041869
24Selective tooth agenesis (HP:0001592)3.06260317
25Cerebral edema (HP:0002181)3.04946791
26Colon cancer (HP:0003003)3.03729746
27Abdominal situs inversus (HP:0003363)3.02611079
28Abnormality of abdominal situs (HP:0011620)3.02611079
29Absent radius (HP:0003974)3.01876085
303-Methylglutaconic aciduria (HP:0003535)2.99626123
31Abnormality of the astrocytes (HP:0100707)2.99446287
32Astrocytoma (HP:0009592)2.99446287
33Hyperalaninemia (HP:0003348)2.98828824
34Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.98828824
35Abnormality of alanine metabolism (HP:0010916)2.98828824
36Abnormal number of erythroid precursors (HP:0012131)2.98161623
37Esophageal atresia (HP:0002032)2.96034508
38Septo-optic dysplasia (HP:0100842)2.94227115
39Lipid accumulation in hepatocytes (HP:0006561)2.89124701
40Aplasia/hypoplasia of the humerus (HP:0006507)2.89124432
41Respiratory difficulties (HP:0002880)2.85760476
42Agnosia (HP:0010524)2.83989101
43Basal cell carcinoma (HP:0002671)2.83644300
44Missing ribs (HP:0000921)2.83465271
45Patellar aplasia (HP:0006443)2.80664818
46Aplasia involving forearm bones (HP:0009822)2.78824209
47Absent forearm bone (HP:0003953)2.78824209
48Hepatocellular necrosis (HP:0001404)2.77862823
49Absent thumb (HP:0009777)2.76356271
50Increased muscle lipid content (HP:0009058)2.72620950
51Abnormality of the salivary glands (HP:0010286)2.69070227
52Exercise intolerance (HP:0003546)2.68492806
53Lactic acidosis (HP:0003128)2.67216549
54Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.66310923
55Hepatic necrosis (HP:0002605)2.64994347
56Rectovaginal fistula (HP:0000143)2.64846979
57Rectal fistula (HP:0100590)2.64846979
58Abnormality of homocysteine metabolism (HP:0010919)2.64488071
59Homocystinuria (HP:0002156)2.64488071
60Cleft eyelid (HP:0000625)2.63850073
61Asplenia (HP:0001746)2.63198498
62Renal Fanconi syndrome (HP:0001994)2.62532641
63Methylmalonic acidemia (HP:0002912)2.62525321
64Hypoglycemic seizures (HP:0002173)2.62483811
65Type 1 muscle fiber predominance (HP:0003803)2.62229536
66Aplasia/Hypoplasia of the patella (HP:0006498)2.62227914
67Hypoglycemic coma (HP:0001325)2.57667580
68Respiratory failure (HP:0002878)2.56686149
69Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.52858534
70Muscle hypertrophy of the lower extremities (HP:0008968)2.50915608
71Short humerus (HP:0005792)2.50289215
72Hyperglycinemia (HP:0002154)2.49249639
73Neoplasm of striated muscle (HP:0009728)2.48085066
74Sudden death (HP:0001699)2.47482171
75Glioma (HP:0009733)2.47340611
76Ventricular tachycardia (HP:0004756)2.43584658
77Increased serum lactate (HP:0002151)2.40410515
78Congenital, generalized hypertrichosis (HP:0004540)2.40281395
79Macrocytic anemia (HP:0001972)2.39703078
80Aplasia/Hypoplasia of the spleen (HP:0010451)2.37695642
81Amaurosis fugax (HP:0100576)2.35476851
82Oral leukoplakia (HP:0002745)2.33637801
83Premature ovarian failure (HP:0008209)2.33091541
84Muscle fiber splitting (HP:0003555)2.30675293
85Distal lower limb muscle weakness (HP:0009053)2.30344653
86Multiple enchondromatosis (HP:0005701)2.30172215
87Adenoma sebaceum (HP:0009720)2.29626823
88Angiofibromas (HP:0010615)2.29626823
89Vaginal fistula (HP:0004320)2.28123194
90Muscle stiffness (HP:0003552)2.26527215
91Intestinal fistula (HP:0100819)2.26245752
92Calf muscle hypertrophy (HP:0008981)2.25403568
93Hyperglycinuria (HP:0003108)2.24771889
94Rhabdomyolysis (HP:0003201)2.24079274
95Methylmalonic aciduria (HP:0012120)2.23075039
96Exertional dyspnea (HP:0002875)2.22889772
97Abnormality of serum amino acid levels (HP:0003112)2.20783878
98Supernumerary bones of the axial skeleton (HP:0009144)2.20431502
99Progressive muscle weakness (HP:0003323)2.19927537
100Impulsivity (HP:0100710)2.18478088
101Depressed nasal tip (HP:0000437)2.18100662
102Areflexia of lower limbs (HP:0002522)2.14059508
103Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.14019870
104Decreased activity of mitochondrial respiratory chain (HP:0008972)2.14019870
105Partial duplication of the phalanx of hand (HP:0009999)2.11867290
106Supernumerary ribs (HP:0005815)2.11817017
107Hypoplastic ischia (HP:0003175)2.10951207
108Trismus (HP:0000211)2.10538052
109Increased connective tissue (HP:0009025)2.09571867
110Exercise-induced myalgia (HP:0003738)2.09277634
111Gastrointestinal atresia (HP:0002589)2.09053733
112Neoplasm of the pancreas (HP:0002894)2.08168032
113Shawl scrotum (HP:0000049)2.07501699
114Annular pancreas (HP:0001734)2.05322355
115Pallor (HP:0000980)2.05285349
116Absent septum pellucidum (HP:0001331)2.05268253
117Sex reversal (HP:0012245)2.04548832
118Abnormal sex determination (HP:0012244)2.04548832
119Absent phalangeal crease (HP:0006109)2.03541980
120Vertebral hypoplasia (HP:0008417)2.03099887
121Aplasia/Hypoplasia of the vertebrae (HP:0008515)2.03099887
122Intestinal atresia (HP:0011100)2.01872608
123Chromosomal breakage induced by crosslinking agents (HP:0003221)2.01297752
124Rough bone trabeculation (HP:0100670)2.01223386
125Lethargy (HP:0001254)1.98859198
126Abnormal number of incisors (HP:0011064)1.98780553
127Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.98058285
128Chromsome breakage (HP:0040012)1.97824670
129Exercise-induced muscle cramps (HP:0003710)1.95829729
130Rimmed vacuoles (HP:0003805)1.95365746
131Optic disc pallor (HP:0000543)1.95074599
132Aplasia/Hypoplasia of the sacrum (HP:0008517)1.94565548
133Pancreatic islet-cell hyperplasia (HP:0004510)1.93819024
134Abnormality of the ileum (HP:0001549)1.92720849
135Vertebral fusion (HP:0002948)1.91697980
136Neoplasm of head and neck (HP:0012288)1.91080960
137Esophageal neoplasm (HP:0100751)1.91080960
138EMG: myopathic abnormalities (HP:0003458)1.89822165
139Vertebral clefting (HP:0008428)1.89704693
140Gout (HP:0001997)1.89273352
141Pendular nystagmus (HP:0012043)1.88288120
142Maternal diabetes (HP:0009800)1.87652607
143Truncus arteriosus (HP:0001660)1.87528335
144Cerebral hypomyelination (HP:0006808)1.87234178
145Biliary tract neoplasm (HP:0100574)1.86247630
146Leukodystrophy (HP:0002415)1.86207960
147Abnormal ventriculo-arterial connection (HP:0011563)1.85677140
148Transposition of the great arteries (HP:0001669)1.85677140
149Abnormal connection of the cardiac segments (HP:0011545)1.85677140
150Hyporeflexia of lower limbs (HP:0002600)1.85164384
151Abnormality of the calf musculature (HP:0001430)1.85023122
152Hyperinsulinemic hypoglycemia (HP:0000825)1.84453127
153Atresia of the external auditory canal (HP:0000413)1.84412083
154Meckel diverticulum (HP:0002245)1.83996155
155Abnormality of the septum pellucidum (HP:0007375)1.82875444
156Myopathic facies (HP:0002058)1.82826809
157Metaphyseal cupping (HP:0003021)1.82751527
158Testicular atrophy (HP:0000029)1.81007247
159Megaloblastic anemia (HP:0001889)1.80591421
160Abnormality of the nasolacrimal system (HP:0000614)1.80408841
161Tracheoesophageal fistula (HP:0002575)1.77650631
162Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.77222217
163Difficulty climbing stairs (HP:0003551)1.76959648
164Proximal placement of thumb (HP:0009623)1.76443777
165Symptomatic seizures (HP:0011145)1.76346985
166Squamous cell carcinoma (HP:0002860)1.76123860
16711 pairs of ribs (HP:0000878)1.75803986
168Nasolacrimal duct obstruction (HP:0000579)1.74683193
169Porencephaly (HP:0002132)1.74622906
170Unsteady gait (HP:0002317)1.73526343
171Poor suck (HP:0002033)1.71390375
172Abnormality of glycine metabolism (HP:0010895)1.71266469
173Abnormality of serine family amino acid metabolism (HP:0010894)1.71266469
174Abnormality of renal resorption (HP:0011038)1.68978465
175Distal arthrogryposis (HP:0005684)1.67661721
176Centrally nucleated skeletal muscle fibers (HP:0003687)1.67318529
177Hyperphosphaturia (HP:0003109)1.65207256
178Abnormality of the lacrimal duct (HP:0011481)1.64861575

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA24.81468580
2WEE13.62759020
3NME13.23245096
4BUB13.13580819
5PBK2.99363001
6CDK122.91377220
7RPS6KB22.88788349
8VRK22.86840477
9TLK12.74129689
10NEK12.69775152
11CDC72.56997726
12TAF12.41945542
13NEK22.39954947
14PKN22.34624529
15MAPKAPK32.18558643
16TIE12.17867774
17NME22.12248431
18PLK42.07332992
19TTK2.02376524
20FLT32.00476583
21TNIK1.99387624
22CDK71.98020619
23SRPK11.85551241
24TSSK61.84944410
25BCKDK1.76895778
26TGFBR11.69885034
27AKT31.65745796
28DYRK31.61642720
29MAP2K31.56395819
30ZAK1.54679826
31PLK11.51309468
32ICK1.44914403
33MAP3K91.42975674
34CHEK21.40815834
35TTN1.39749860
36CDK41.37535849
37DYRK21.33535650
38PAK41.32835445
39MAP3K81.18203458
40AURKB1.17018541
41PDK31.16683683
42PDK41.16683683
43ARAF1.15409548
44ATR1.13599661
45KDR1.11805038
46STK161.11274421
47AURKA1.11263211
48VRK11.10695536
49PDK21.10034468
50LATS21.09775188
51ACVR1B1.07007981
52ALK1.04548845
53PIM11.03952491
54PNCK1.02071661
55CHEK11.01847380
56STK40.99829589
57MAP3K30.97842039
58CCNB10.97177088
59EIF2AK10.92639471
60MAP3K110.91993715
61MAP3K60.89716831
62MAPK120.89503740
63BRD40.88019546
64EEF2K0.85430206
65MKNK10.85080085
66DMPK0.82231970
67PRKCI0.82059132
68CDK20.81382308
69STK38L0.77858514
70MTOR0.76890723
71MKNK20.76533969
72BRSK20.74598976
73BMPR1B0.74200744
74PASK0.73319038
75CSNK2A20.72855056
76ATM0.70197752
77CDK190.70171845
78DAPK30.68745588
79AKT20.66264561
80ABL20.64611861
81MATK0.62482016
82TGFBR20.62305308
83SCYL20.60797552
84PHKG20.60581827
85PHKG10.60581827
86CAMK10.59477968
87MAP3K100.59355275
88MET0.59302854
89DDR20.58810666
90RPS6KA40.58584751
91STK100.57677975
92RPS6KA50.57342166
93MAP2K70.56487189
94CAMK1G0.55410175
95CSNK2A10.55332390
96BMX0.54487005
97PAK10.53288983
98PRKG20.52477840
99EIF2AK30.52072442
100PDGFRA0.49828618
101STK30.48701467
102CDK60.48624167
103MARK30.47474108
104CSNK1A10.46439625
105CSNK1D0.44937890
106PINK10.43740241
107CSNK1E0.43708328
108PLK30.43260138
109TRIB30.42665061
110ILK0.42520872
111MST40.42049124
112PTK2B0.41560842
113LRRK20.41421362
114PRKG10.41072609
115LIMK10.40027534
116CDK10.39893685
117IRAK20.39632365
118STK240.39608804
119DAPK10.39352002
120SGK10.37078857
121PRKDC0.35649015
122BRSK10.35152518
123GRK10.34966320
124TYRO30.34415090
125MUSK0.34054127
126MYLK0.33522324
127OBSCN0.33377778
128FES0.32735446
129RIPK10.31917615
130BRAF0.31167742
131MAPK10.30658518
132RPS6KC10.30097093
133RPS6KL10.30097093
134RPS6KA10.29469172
135PRKACB0.29411928
136GSK3B0.28844289
137PRKACA0.27520717
138CAMK2G0.26074346
139CDK30.25819705
140CSNK1G10.24843246

Predicted pathways (KEGG)

RankGene SetZ-score
1Mismatch repair_Homo sapiens_hsa034304.43502112
2Ribosome_Homo sapiens_hsa030104.39284731
3DNA replication_Homo sapiens_hsa030304.34451263
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.71936662
5Spliceosome_Homo sapiens_hsa030403.23992715
6RNA transport_Homo sapiens_hsa030132.99463514
7RNA polymerase_Homo sapiens_hsa030202.95299167
8Base excision repair_Homo sapiens_hsa034102.89078067
9Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.70034514
10Nucleotide excision repair_Homo sapiens_hsa034202.68604169
11Homologous recombination_Homo sapiens_hsa034402.37869819
12One carbon pool by folate_Homo sapiens_hsa006702.33315798
132-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.22009463
14Proteasome_Homo sapiens_hsa030502.13365332
15Cell cycle_Homo sapiens_hsa041102.07888561
16Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.07563298
17Pyrimidine metabolism_Homo sapiens_hsa002401.96979682
18Protein export_Homo sapiens_hsa030601.96552918
19Fanconi anemia pathway_Homo sapiens_hsa034601.79670786
20mRNA surveillance pathway_Homo sapiens_hsa030151.70061918
21Basal transcription factors_Homo sapiens_hsa030221.60873624
22RNA degradation_Homo sapiens_hsa030181.59252057
23Biosynthesis of amino acids_Homo sapiens_hsa012301.55118716
24p53 signaling pathway_Homo sapiens_hsa041151.52587362
25Non-homologous end-joining_Homo sapiens_hsa034501.45760771
26Systemic lupus erythematosus_Homo sapiens_hsa053221.34032499
27Carbon metabolism_Homo sapiens_hsa012001.29748272
28Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.15276984
29Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.11486414
30Sulfur relay system_Homo sapiens_hsa041221.09139605
31Folate biosynthesis_Homo sapiens_hsa007901.09129953
32Huntingtons disease_Homo sapiens_hsa050161.06284778
33Vitamin digestion and absorption_Homo sapiens_hsa049771.04841996
34Selenocompound metabolism_Homo sapiens_hsa004501.03874870
35Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.01411573
36Purine metabolism_Homo sapiens_hsa002301.01160890
37Parkinsons disease_Homo sapiens_hsa050121.00435940
38Notch signaling pathway_Homo sapiens_hsa043300.95878854
39Fructose and mannose metabolism_Homo sapiens_hsa000510.94441392
40Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.84016165
41Cysteine and methionine metabolism_Homo sapiens_hsa002700.83866001
42Basal cell carcinoma_Homo sapiens_hsa052170.83064294
43Cardiac muscle contraction_Homo sapiens_hsa042600.81401191
44Oocyte meiosis_Homo sapiens_hsa041140.80254057
45Hippo signaling pathway_Homo sapiens_hsa043900.79031355
46Epstein-Barr virus infection_Homo sapiens_hsa051690.77789036
47Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.77751927
48Oxidative phosphorylation_Homo sapiens_hsa001900.75872881
49Fatty acid degradation_Homo sapiens_hsa000710.73386419
50Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.73363073
51Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.72583747
52Viral carcinogenesis_Homo sapiens_hsa052030.70577173
53Galactose metabolism_Homo sapiens_hsa000520.68206047
54Vitamin B6 metabolism_Homo sapiens_hsa007500.67710853
55Thyroid cancer_Homo sapiens_hsa052160.65419672
56Transcriptional misregulation in cancer_Homo sapiens_hsa052020.64701577
57Central carbon metabolism in cancer_Homo sapiens_hsa052300.63983635
58Small cell lung cancer_Homo sapiens_hsa052220.63684855
59Arginine and proline metabolism_Homo sapiens_hsa003300.62533637
60Sulfur metabolism_Homo sapiens_hsa009200.60961839
61TGF-beta signaling pathway_Homo sapiens_hsa043500.60627866
62Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.60050880
63Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.59989974
64Fatty acid elongation_Homo sapiens_hsa000620.59811220
65Phenylalanine metabolism_Homo sapiens_hsa003600.59599885
66Tight junction_Homo sapiens_hsa045300.59536382
67Hedgehog signaling pathway_Homo sapiens_hsa043400.58911951
68Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.58567155
69Cyanoamino acid metabolism_Homo sapiens_hsa004600.56659754
70Pentose phosphate pathway_Homo sapiens_hsa000300.56270200
71MicroRNAs in cancer_Homo sapiens_hsa052060.56055783
72Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.54734493
73Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.53776743
74HIF-1 signaling pathway_Homo sapiens_hsa040660.53348348
75mTOR signaling pathway_Homo sapiens_hsa041500.50681466
76Alcoholism_Homo sapiens_hsa050340.50046419
77HTLV-I infection_Homo sapiens_hsa051660.50008192
78Pyruvate metabolism_Homo sapiens_hsa006200.48120143
79Propanoate metabolism_Homo sapiens_hsa006400.47701447
80Bladder cancer_Homo sapiens_hsa052190.47429434
81beta-Alanine metabolism_Homo sapiens_hsa004100.45697820
82Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.45552648
83Arginine biosynthesis_Homo sapiens_hsa002200.44646725
84Tyrosine metabolism_Homo sapiens_hsa003500.44533901
85Herpes simplex infection_Homo sapiens_hsa051680.44166932
86Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.44071810
87Fat digestion and absorption_Homo sapiens_hsa049750.43997486
88Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.42432088
89Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.41927395
90Circadian rhythm_Homo sapiens_hsa047100.40700391
91Steroid biosynthesis_Homo sapiens_hsa001000.39184851
92Lysine degradation_Homo sapiens_hsa003100.39073417
93Pathways in cancer_Homo sapiens_hsa052000.38316773
94Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.36427225
95Adherens junction_Homo sapiens_hsa045200.34846327
96Maturity onset diabetes of the young_Homo sapiens_hsa049500.33905168
97Fatty acid metabolism_Homo sapiens_hsa012120.32523597
98Dilated cardiomyopathy_Homo sapiens_hsa054140.32333458
99Nitrogen metabolism_Homo sapiens_hsa009100.32243166
100Viral myocarditis_Homo sapiens_hsa054160.31796389
101PI3K-Akt signaling pathway_Homo sapiens_hsa041510.31062716
102Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.31014994
103Tryptophan metabolism_Homo sapiens_hsa003800.30020915
104Alzheimers disease_Homo sapiens_hsa050100.29694129
105Acute myeloid leukemia_Homo sapiens_hsa052210.29015451
106ECM-receptor interaction_Homo sapiens_hsa045120.28874955
107Glutathione metabolism_Homo sapiens_hsa004800.28764743
108Drug metabolism - other enzymes_Homo sapiens_hsa009830.28078189
109Retinol metabolism_Homo sapiens_hsa008300.27362990
110Focal adhesion_Homo sapiens_hsa045100.25757324
111Regulation of autophagy_Homo sapiens_hsa041400.22957207
112AMPK signaling pathway_Homo sapiens_hsa041520.22758800
113Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.22406800
114Wnt signaling pathway_Homo sapiens_hsa043100.21861708
115Longevity regulating pathway - mammal_Homo sapiens_hsa042110.21722115
116Metabolic pathways_Homo sapiens_hsa011000.21454911
117Insulin signaling pathway_Homo sapiens_hsa049100.19741404
118Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.19578662
119Thyroid hormone signaling pathway_Homo sapiens_hsa049190.18292417
120Apoptosis_Homo sapiens_hsa042100.16544206
121Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.16421827
122Antigen processing and presentation_Homo sapiens_hsa046120.16417035
123Pentose and glucuronate interconversions_Homo sapiens_hsa000400.14699432
124Olfactory transduction_Homo sapiens_hsa047400.14559410
125Nicotine addiction_Homo sapiens_hsa050330.14123153
126Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.13561296
127Peroxisome_Homo sapiens_hsa041460.12114194
128Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.11861092
129Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.11337298
130Linoleic acid metabolism_Homo sapiens_hsa005910.09380885
131Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.07816662
132Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.07116578
133Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.06461058
134Taste transduction_Homo sapiens_hsa047420.04028865
135Glucagon signaling pathway_Homo sapiens_hsa049220.02908032

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