TCF12

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the basic helix-loop-helix (bHLH) E-protein family that recognizes the consensus binding site (E-box) CANNTG. This encoded protein is expressed in many tissues, among them skeletal muscle, thymus, B- and T-cells, and may participate in regulating lineage-specific gene expression through the formation of heterodimers with other bHLH E-proteins. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neuron projection extension involved in neuron projection guidance (GO:1902284)6.09154247
2axon extension involved in axon guidance (GO:0048846)6.09154247
3presynaptic membrane assembly (GO:0097105)5.58188233
4pyrimidine nucleobase catabolic process (GO:0006208)5.05959526
5dopaminergic neuron differentiation (GO:0071542)4.99185364
6presynaptic membrane organization (GO:0097090)4.94487041
7postsynaptic membrane organization (GO:0001941)4.90064549
8negative regulation of axon guidance (GO:1902668)4.81210195
9forebrain neuron differentiation (GO:0021879)4.79556613
10negative regulation of axon extension involved in axon guidance (GO:0048843)4.53103840
11epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)4.17482517
12ganglion development (GO:0061548)4.05890416
13neuronal stem cell maintenance (GO:0097150)4.00544085
14regulation of somitogenesis (GO:0014807)3.90646563
15regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.85782128
16paraxial mesoderm development (GO:0048339)3.82005420
17endocardial cushion morphogenesis (GO:0003203)3.81943253
18lateral sprouting from an epithelium (GO:0060601)3.80854817
19axonal fasciculation (GO:0007413)3.79826071
20nucleobase catabolic process (GO:0046113)3.79680852
21radial glial cell differentiation (GO:0060019)3.73282115
22neuron cell-cell adhesion (GO:0007158)3.71064338
23establishment of nucleus localization (GO:0040023)3.65832910
24mesenchyme morphogenesis (GO:0072132)3.61000231
25DNA topological change (GO:0006265)3.59500216
26negative regulation of oligodendrocyte differentiation (GO:0048715)3.51896208
27mechanosensory behavior (GO:0007638)3.48599691
28epithelial cell differentiation involved in prostate gland development (GO:0060742)3.48155699
29central nervous system projection neuron axonogenesis (GO:0021952)3.45698015
30sympathetic nervous system development (GO:0048485)3.39793946
31appendage development (GO:0048736)3.38514054
32limb development (GO:0060173)3.38514054
33planar cell polarity pathway involved in neural tube closure (GO:0090179)3.37801042
34regulation of development, heterochronic (GO:0040034)3.35368894
35neuron recognition (GO:0008038)3.34507332
36regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.30256007
37glomerular filtration (GO:0003094)3.28485581
38heart valve formation (GO:0003188)3.28273813
39negative chemotaxis (GO:0050919)3.27030349
40regulation of timing of cell differentiation (GO:0048505)3.26224990
41cell migration involved in heart development (GO:0060973)3.21897190
42mitotic sister chromatid cohesion (GO:0007064)3.18965511
43calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)3.18317224
44coronary vasculature morphogenesis (GO:0060977)3.18160732
45regulation of epithelial cell proliferation involved in prostate gland development (GO:0060768)3.17976050
46positive regulation of gastrulation (GO:2000543)3.16333938
47Notch signaling involved in heart development (GO:0061314)3.16223277
48cerebral cortex radially oriented cell migration (GO:0021799)3.16011158
49regulation of axon guidance (GO:1902667)3.15563869
50eye photoreceptor cell differentiation (GO:0001754)3.07406221
51photoreceptor cell differentiation (GO:0046530)3.07406221
52DNA unwinding involved in DNA replication (GO:0006268)3.07378351
53spinal cord association neuron differentiation (GO:0021527)3.06988004
54astrocyte development (GO:0014002)3.05927669
55neuron fate determination (GO:0048664)3.02221381
56positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.99564813
57primitive streak formation (GO:0090009)2.97270064
58negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)2.95770549
59olfactory bulb development (GO:0021772)2.95146563
60cell proliferation involved in metanephros development (GO:0072203)2.95119487
61cell surface receptor signaling pathway involved in heart development (GO:0061311)2.93027417
62embryonic hindlimb morphogenesis (GO:0035116)2.92237299
63hindlimb morphogenesis (GO:0035137)2.91414668
64outer ear morphogenesis (GO:0042473)2.90091852
65renal filtration (GO:0097205)2.88658643
66regulation of chemokine-mediated signaling pathway (GO:0070099)2.88350364
67neuron fate commitment (GO:0048663)2.87310010
68somatic stem cell division (GO:0048103)2.85259796
69cochlea morphogenesis (GO:0090103)2.83781567
70G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.83777424
71regulation of oligodendrocyte differentiation (GO:0048713)2.83228418
72negative regulation of chondrocyte differentiation (GO:0032331)2.82977080
73hippo signaling (GO:0035329)2.82750991
74nonmotile primary cilium assembly (GO:0035058)2.82725084
75negative regulation of neurotransmitter transport (GO:0051589)2.79190297
76cellular response to cholesterol (GO:0071397)2.78965462
77central nervous system neuron axonogenesis (GO:0021955)2.78899229
78regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.76827263
79regulation of axon extension involved in axon guidance (GO:0048841)2.76613880
80dendrite morphogenesis (GO:0048813)2.74354442
81positive regulation of epithelial to mesenchymal transition (GO:0010718)2.74062243
82dermatan sulfate biosynthetic process (GO:0030208)2.73443099
83striated muscle cell proliferation (GO:0014855)2.72164822
84alternative mRNA splicing, via spliceosome (GO:0000380)2.70600001
85positive regulation of oligodendrocyte differentiation (GO:0048714)2.69241058
86cerebral cortex cell migration (GO:0021795)2.68279635
87chondrocyte development (GO:0002063)2.67692919
88regulation of RNA export from nucleus (GO:0046831)2.66771413
89nucleus localization (GO:0051647)2.66014540
90regulation of sister chromatid cohesion (GO:0007063)2.65415649
91auditory behavior (GO:0031223)2.64353350
92positive regulation of neural precursor cell proliferation (GO:2000179)2.63599140
93neural tube development (GO:0021915)2.63369828
94establishment of tissue polarity (GO:0007164)2.62760533
95establishment of planar polarity (GO:0001736)2.62760533
96positive regulation of BMP signaling pathway (GO:0030513)2.62472025
97V(D)J recombination (GO:0033151)2.60941446
98collecting duct development (GO:0072044)2.59505557
99dorsal/ventral axis specification (GO:0009950)2.58150358
100intraciliary transport (GO:0042073)2.57617931
101cell differentiation in spinal cord (GO:0021515)2.56778843
102cranial nerve development (GO:0021545)2.56508979
103mesenchymal cell proliferation (GO:0010463)2.55937167
104mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.55705316
105head development (GO:0060322)2.55694405
106Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.55428545
107negative regulation of neurotransmitter secretion (GO:0046929)2.54493113
108regulation of establishment of planar polarity (GO:0090175)2.54417328
109astrocyte differentiation (GO:0048708)2.54124943
110negative regulation of smoothened signaling pathway (GO:0045879)2.52437293
111negative regulation of chemotaxis (GO:0050922)2.52172535
112spinal cord development (GO:0021510)2.52111186
113regulation of heart morphogenesis (GO:2000826)2.51412281
114face development (GO:0060324)2.50735296
115limb bud formation (GO:0060174)2.50276079
116microtubule depolymerization (GO:0007019)2.49921223
117positive regulation of synapse assembly (GO:0051965)2.48689001
118negative regulation of axon extension (GO:0030517)2.48470011
119regulation of mesenchymal cell apoptotic process (GO:2001053)2.48273420
120negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.47993800
121peripheral nervous system neuron development (GO:0048935)2.47027974
122resolution of meiotic recombination intermediates (GO:0000712)2.46164153
123epithelial to mesenchymal transition (GO:0001837)2.45622489
124cardiac epithelial to mesenchymal transition (GO:0060317)2.43911516
125regulation of mesenchymal cell proliferation (GO:0010464)2.43854089
126positive regulation of mesenchymal cell proliferation (GO:0002053)2.43836531
127regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.43310577
128embryonic foregut morphogenesis (GO:0048617)2.42604514
129glomerular basement membrane development (GO:0032836)2.41809368
130glucocorticoid receptor signaling pathway (GO:0042921)2.41336242
131neural tube formation (GO:0001841)2.41249009
132mesenchymal-epithelial cell signaling (GO:0060638)2.40462036
133dermatan sulfate metabolic process (GO:0030205)2.40420843
134muscle cell proliferation (GO:0033002)2.40128173
135insulin-like growth factor receptor signaling pathway (GO:0048009)2.39036681
136stem cell development (GO:0048864)2.38886680
137regulation of nephron tubule epithelial cell differentiation (GO:0072182)2.38678950
138mesenchymal cell development (GO:0014031)2.38086439
139mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.37821565
140positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.37821565
141embryonic cranial skeleton morphogenesis (GO:0048701)2.37057683
142positive regulation of astrocyte differentiation (GO:0048711)2.36895761
143regulation of pigment cell differentiation (GO:0050932)2.36797816
144negative regulation of RNA splicing (GO:0033119)2.36317999
145midbrain development (GO:0030901)2.35674892
146positive regulation of neuroblast proliferation (GO:0002052)2.35180140
147cerebral cortex development (GO:0021987)2.34863790
148retinal ganglion cell axon guidance (GO:0031290)2.34701089
149sister chromatid segregation (GO:0000819)2.34410931
150synapse assembly (GO:0007416)2.34103061
151regulation of transcription from RNA polymerase II promoter involved in heart development (GO:1901212.33482715
152somite development (GO:0061053)2.33013693
153central nervous system neuron development (GO:0021954)2.32613702
154negative regulation of transcription regulatory region DNA binding (GO:2000678)2.31507433
155establishment of mitochondrion localization (GO:0051654)2.31376755
156positive regulation of male gonad development (GO:2000020)2.31212994
157negative regulation of neuron differentiation (GO:0045665)2.29132621
158regulation of respiratory system process (GO:0044065)2.28523098
159oligodendrocyte differentiation (GO:0048709)2.28407241
160regulation of growth hormone secretion (GO:0060123)2.27677013
161lens morphogenesis in camera-type eye (GO:0002089)2.27624926
162glial cell proliferation (GO:0014009)2.26084342
163cellular response to sterol (GO:0036315)2.25836301
164regulation of non-canonical Wnt signaling pathway (GO:2000050)2.25236443
165morphogenesis of an epithelial sheet (GO:0002011)2.23652117
166neuron fate specification (GO:0048665)2.23425916
167enteric nervous system development (GO:0048484)2.23159361

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse5.30712458
2E2F7_22180533_ChIP-Seq_HELA_Human5.11670707
3FOXM1_23109430_ChIP-Seq_U2OS_Human4.66041229
4TP63_19390658_ChIP-ChIP_HaCaT_Human3.92944820
5EZH2_22144423_ChIP-Seq_EOC_Human3.90866770
6TP63_17297297_ChIP-ChIP_HaCaT_Human3.82064261
7FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.79119786
8RBPJ_22232070_ChIP-Seq_NCS_Mouse3.77639781
9EGR1_19374776_ChIP-ChIP_THP-1_Human3.70402670
10GBX2_23144817_ChIP-Seq_PC3_Human3.05098824
11* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.91856907
12SALL1_21062744_ChIP-ChIP_HESCs_Human2.91060936
13NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.68493762
14E2F4_17652178_ChIP-ChIP_JURKAT_Human2.64215157
15STAT6_21828071_ChIP-Seq_BEAS2B_Human2.58840249
16ZFP57_27257070_Chip-Seq_ESCs_Mouse2.56233483
17WT1_19549856_ChIP-ChIP_CCG9911_Human2.48741973
18* POU3F2_20337985_ChIP-ChIP_501MEL_Human2.44194509
19IGF1R_20145208_ChIP-Seq_DFB_Human2.26272925
20WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.23575252
21TRIM28_21343339_ChIP-Seq_HEK293_Human2.21050373
22FUS_26573619_Chip-Seq_HEK293_Human2.20936599
23KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.14691984
24FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.13581909
25HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse2.10549414
26CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.09348073
27RNF2_16625203_ChIP-ChIP_MESCs_Mouse2.06947314
28ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.02323056
29CTBP2_25329375_ChIP-Seq_LNCAP_Human1.96110908
30PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.95560269
31* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.92573374
32ZNF274_21170338_ChIP-Seq_K562_Hela1.87794650
33TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.86678931
34TAF15_26573619_Chip-Seq_HEK293_Human1.83865044
35* POU5F1_16153702_ChIP-ChIP_HESCs_Human1.83741003
36MYC_22102868_ChIP-Seq_BL_Human1.81596200
37* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.81346519
38* FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.77045045
39* P300_19829295_ChIP-Seq_ESCs_Human1.71879459
40MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.70699647
41* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.69540117
42CTBP1_25329375_ChIP-Seq_LNCAP_Human1.67020574
43FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.65506337
44* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.64323039
45SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.64067064
46* ISL1_27105846_Chip-Seq_CPCs_Mouse1.63153804
47SMAD4_21799915_ChIP-Seq_A2780_Human1.62096509
48PIAS1_25552417_ChIP-Seq_VCAP_Human1.60094532
49TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.58035447
50VDR_22108803_ChIP-Seq_LS180_Human1.57770015
51EED_16625203_ChIP-ChIP_MESCs_Mouse1.56258925
52RNF2_27304074_Chip-Seq_NSC_Mouse1.53270332
53SOX2_16153702_ChIP-ChIP_HESCs_Human1.52597904
54NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.49686368
55* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.49052372
56GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.48162989
57BRD4_25478319_ChIP-Seq_HGPS_Human1.47302278
58SOX9_26525672_Chip-Seq_HEART_Mouse1.46957009
59TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.46725313
60SMAD3_21741376_ChIP-Seq_EPCs_Human1.46463089
61CBX2_27304074_Chip-Seq_ESCs_Mouse1.45950811
62ZFP281_27345836_Chip-Seq_ESCs_Mouse1.45678405
63CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.44902922
64TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.44437419
65SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.44130763
66TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.43452070
67POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.43452070
68CIITA_25753668_ChIP-Seq_RAJI_Human1.41192608
69NFIB_24661679_ChIP-Seq_LUNG_Mouse1.40438129
70TP53_20018659_ChIP-ChIP_R1E_Mouse1.37782498
71ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.36672860
72AR_21909140_ChIP-Seq_LNCAP_Human1.36355374
73SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.36240222
74EWS_26573619_Chip-Seq_HEK293_Human1.35776223
75STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.35232924
76NANOG_18555785_Chip-Seq_ESCs_Mouse1.33553488
77TOP2B_26459242_ChIP-Seq_MCF-7_Human1.33320766
78EZH2_27304074_Chip-Seq_ESCs_Mouse1.32793190
79TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.32615925
80SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.32253439
81TBX3_20139965_ChIP-Seq_ESCs_Mouse1.31217922
82TBX3_20139965_ChIP-Seq_MESCs_Mouse1.30948151
83RING1B_27294783_Chip-Seq_NPCs_Mouse1.30715537
84SOX2_18555785_ChIP-Seq_MESCs_Mouse1.30255560
85CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.29369391
86OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.29117969
87KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.29025470
88PKCTHETA_26484144_Chip-Seq_BREAST_Human1.28505360
89KDM2B_26808549_Chip-Seq_JURKAT_Human1.26548055
90NR3C1_21868756_ChIP-Seq_MCF10A_Human1.26109233
91* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.25970680
92GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.25452579
93KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.24920590
94EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.24296750
95STAT3_23295773_ChIP-Seq_U87_Human1.24012423
96TP53_16413492_ChIP-PET_HCT116_Human1.23919649
97PCGF2_27294783_Chip-Seq_NPCs_Mouse1.23670224
98KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.21074022
99E2F1_21310950_ChIP-Seq_MCF-7_Human1.19798625
100* RNF2_27304074_Chip-Seq_ESCs_Mouse1.19508998
101UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.18941722
102RNF2_18974828_ChIP-Seq_MESCs_Mouse1.18080211
103EZH2_18974828_ChIP-Seq_MESCs_Mouse1.18080211
104ZFP281_18757296_ChIP-ChIP_E14_Mouse1.17747638
105ELK1_19687146_ChIP-ChIP_HELA_Human1.16613349
106FLI1_27457419_Chip-Seq_LIVER_Mouse1.16467996
107TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.14612526
108SUZ12_27294783_Chip-Seq_NPCs_Mouse1.13940993
109ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.13807822
110ZNF217_24962896_ChIP-Seq_MCF-7_Human1.13273828
111LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12320811
112SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.11284143
113PCGF2_27294783_Chip-Seq_ESCs_Mouse1.10626482
114EZH2_27294783_Chip-Seq_NPCs_Mouse1.09489327
115AR_21572438_ChIP-Seq_LNCaP_Human1.09248905
116AR_25329375_ChIP-Seq_VCAP_Human1.09222926
117VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.09158314
118P53_22387025_ChIP-Seq_ESCs_Mouse1.08585892
119SOX2_21211035_ChIP-Seq_LN229_Gbm1.07900929
120RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.07466969
121IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.07326739
122CBP_20019798_ChIP-Seq_JUKART_Human1.07326739
123* RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.07159269
124* RUNX2_22187159_ChIP-Seq_PCA_Human1.07007019
125KDM2B_26808549_Chip-Seq_DND41_Human1.06828208
126E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.06488469
127NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.06443328
128NRF2_20460467_ChIP-Seq_MEFs_Mouse1.06443328
129MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.06013624
130PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.05936430
131SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.05775098
132TCF7_22412390_ChIP-Seq_EML_Mouse1.05399903
133NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.04489503
134EP300_21415370_ChIP-Seq_HL-1_Mouse1.04400164
135STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.02339632
136NANOG_21062744_ChIP-ChIP_HESCs_Human1.01734455
137TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.00287850
138POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.98836813
139CLOCK_20551151_ChIP-Seq_293T_Human0.98599750
140PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.97968302
141CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.96046314
142SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.96046253
143SOX9_24532713_ChIP-Seq_HFSC_Mouse0.95173528
144KDM2B_26808549_Chip-Seq_SUP-B15_Human0.95121279
145YAP1_20516196_ChIP-Seq_MESCs_Mouse0.95085661
146SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.94838252
147RING1B_27294783_Chip-Seq_ESCs_Mouse0.92622328
148CHD1_26751641_Chip-Seq_LNCaP_Human0.92193962
149YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.92164418
150AHR_22903824_ChIP-Seq_MCF-7_Human0.91657765
151STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.91134597
152ARNT_22903824_ChIP-Seq_MCF-7_Human0.91134574
153JARID2_20064375_ChIP-Seq_MESCs_Mouse0.89452017
154NANOG_16153702_ChIP-ChIP_HESCs_Human0.88861748
155SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.88717258
156UBF1/2_26484160_Chip-Seq_HMECs_Human0.88165630
157SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.87194978
158* WT1_25993318_ChIP-Seq_PODOCYTE_Human0.85114374
159HIF1A_21447827_ChIP-Seq_MCF-7_Human0.84997838
160* TP53_18474530_ChIP-ChIP_U2OS_Human0.84182826
161KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.83356152
162MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.82151613
163TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.80236233
164CJUN_26792858_Chip-Seq_BT549_Human0.79395459

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern3.86223397
2MP0000569_abnormal_digit_pigmentation3.44307076
3MP0000537_abnormal_urethra_morphology3.40910953
4MP0000566_synostosis3.12489808
5MP0005423_abnormal_somatic_nervous2.95643767
6MP0009053_abnormal_anal_canal2.54772903
7MP0002938_white_spotting2.47036845
8MP0010030_abnormal_orbit_morphology2.41931920
9MP0005503_abnormal_tendon_morphology2.26771792
10MP0003937_abnormal_limbs/digits/tail_de2.12387565
11MP0009250_abnormal_appendicular_skeleto2.12100511
12MP0005499_abnormal_olfactory_system2.08639180
13MP0005394_taste/olfaction_phenotype2.08639180
14MP0001529_abnormal_vocalization2.07784495
15MP0003136_yellow_coat_color2.07431575
16MP0003385_abnormal_body_wall2.01459337
17MP0002282_abnormal_trachea_morphology1.92129665
18MP0000733_abnormal_muscle_development1.91420272
19MP0002638_abnormal_pupillary_reflex1.89176354
20MP0008438_abnormal_cutaneous_collagen1.89026680
21MP0003942_abnormal_urinary_system1.87022072
22MP0002932_abnormal_joint_morphology1.83995676
23MP0002822_catalepsy1.81351200
24MP0000049_abnormal_middle_ear1.75665982
25MP0002249_abnormal_larynx_morphology1.74901283
26MP0006054_spinal_hemorrhage1.73631116
27MP0003121_genomic_imprinting1.72805480
28MP0001293_anophthalmia1.71896828
29MP0006276_abnormal_autonomic_nervous1.70990729
30MP0000383_abnormal_hair_follicle1.68635336
31MP0003935_abnormal_craniofacial_develop1.67439230
32MP0000955_abnormal_spinal_cord1.63378266
33MP0003890_abnormal_embryonic-extraembry1.63132895
34MP0004885_abnormal_endolymph1.62487416
35MP0003755_abnormal_palate_morphology1.59796574
36MP0003115_abnormal_respiratory_system1.59203690
37MP0005076_abnormal_cell_differentiation1.58847357
38MP0003123_paternal_imprinting1.57427926
39MP0002736_abnormal_nociception_after1.55843621
40MP0006072_abnormal_retinal_apoptosis1.53918563
41MP0001984_abnormal_olfaction1.51741289
42MP0000428_abnormal_craniofacial_morphol1.51150693
43MP0002233_abnormal_nose_morphology1.51077341
44MP0005171_absent_coat_pigmentation1.49944604
45MP0002116_abnormal_craniofacial_bone1.48916779
46MP0000534_abnormal_ureter_morphology1.48181133
47MP0001849_ear_inflammation1.46082434
48MP0005508_abnormal_skeleton_morphology1.46054254
49MP0004133_heterotaxia1.45807692
50MP0005253_abnormal_eye_physiology1.45630808
51MP0003122_maternal_imprinting1.44157854
52MP0010678_abnormal_skin_adnexa1.42286064
53MP0000432_abnormal_head_morphology1.41883143
54MP0002092_abnormal_eye_morphology1.36814828
55MP0005645_abnormal_hypothalamus_physiol1.35888027
56MP0000762_abnormal_tongue_morphology1.35005635
57MP0002735_abnormal_chemical_nociception1.34396227
58MP0000631_abnormal_neuroendocrine_gland1.32493289
59MP0005623_abnormal_meninges_morphology1.31802717
60MP0002177_abnormal_outer_ear1.29474194
61MP0001486_abnormal_startle_reflex1.29370964
62MP0004381_abnormal_hair_follicle1.27560205
63MP0003705_abnormal_hypodermis_morpholog1.27442253
64MP0004197_abnormal_fetal_growth/weight/1.26495727
65MP0008007_abnormal_cellular_replicative1.26485521
66MP0003119_abnormal_digestive_system1.25392382
67MP0008961_abnormal_basal_metabolism1.25238652
68MP0003315_abnormal_perineum_morphology1.23541700
69MP0003938_abnormal_ear_development1.23181742
70MP0001286_abnormal_eye_development1.22006970
71MP0002184_abnormal_innervation1.21947434
72MP0004859_abnormal_synaptic_plasticity1.21126026
73MP0001299_abnormal_eye_distance/1.20713998
74MP0004272_abnormal_basement_membrane1.20634915
75MP0001346_abnormal_lacrimal_gland1.19344126
76MP0009384_cardiac_valve_regurgitation1.19035184
77MP0002109_abnormal_limb_morphology1.18401508
78MP0005391_vision/eye_phenotype1.18038134
79MP0000026_abnormal_inner_ear1.17753677
80MP0002697_abnormal_eye_size1.17635575
81MP0005187_abnormal_penis_morphology1.16646049
82MP0002102_abnormal_ear_morphology1.16641487
83MP0008789_abnormal_olfactory_epithelium1.16606754
84* MP0002152_abnormal_brain_morphology1.15654612
85MP0002085_abnormal_embryonic_tissue1.15372984
86MP0002084_abnormal_developmental_patter1.14971488
87MP0000647_abnormal_sebaceous_gland1.13983818
88MP0005248_abnormal_Harderian_gland1.13561337
89MP0004808_abnormal_hematopoietic_stem1.12741706
90MP0004270_analgesia1.10164685
91MP0000516_abnormal_urinary_system1.09588798
92MP0005367_renal/urinary_system_phenotyp1.09588798
93MP0003787_abnormal_imprinting1.08823552
94MP0002075_abnormal_coat/hair_pigmentati1.08688328
95MP0001177_atelectasis1.08539643
96MP0002111_abnormal_tail_morphology1.08454021
97MP0001879_abnormal_lymphatic_vessel1.08275247
98MP0002882_abnormal_neuron_morphology1.08080593
99MP0009278_abnormal_bone_marrow1.05191140
100MP0000467_abnormal_esophagus_morphology1.04845083
101MP0002113_abnormal_skeleton_development1.04060687
102MP0002114_abnormal_axial_skeleton1.03653407
103* MP0003861_abnormal_nervous_system1.03447668
104MP0010094_abnormal_chromosome_stability1.03431852
105MP0008057_abnormal_DNA_replication1.03348262
106MP0002234_abnormal_pharynx_morphology1.02474719
107MP0002653_abnormal_ependyma_morphology1.02386748
108MP0000778_abnormal_nervous_system1.01474053
109MP0002752_abnormal_somatic_nervous1.00614776
110MP0000371_diluted_coat_color0.99795904
111MP0010368_abnormal_lymphatic_system0.99324553
112MP0000163_abnormal_cartilage_morphology0.97626883
113MP0002098_abnormal_vibrissa_morphology0.97604843
114MP0002557_abnormal_social/conspecific_i0.96609728
115MP0002095_abnormal_skin_pigmentation0.95995793
116MP0002081_perinatal_lethality0.95377019
117MP0002009_preneoplasia0.94582655
118MP0004134_abnormal_chest_morphology0.94496283
119MP0004811_abnormal_neuron_physiology0.93803660
120MP0003077_abnormal_cell_cycle0.93617153
121MP0002925_abnormal_cardiovascular_devel0.93573706
122MP0002751_abnormal_autonomic_nervous0.92928504
123MP0002115_abnormal_skeleton_extremities0.92603894
124MP0008932_abnormal_embryonic_tissue0.92315156
125MP0002277_abnormal_respiratory_mucosa0.92283152
126MP0003091_abnormal_cell_migration0.90640033
127MP0002734_abnormal_mechanical_nocicepti0.90033202
128MP0005408_hypopigmentation0.90001793
129MP0000767_abnormal_smooth_muscle0.89584317
130MP0001340_abnormal_eyelid_morphology0.89252406
131MP0003567_abnormal_fetal_cardiomyocyte0.88817808
132MP0003941_abnormal_skin_development0.88391962
133MP0000377_abnormal_hair_follicle0.88381426
134MP0001968_abnormal_touch/_nociception0.87799689
135MP0003635_abnormal_synaptic_transmissio0.87608464
136MP0000350_abnormal_cell_proliferation0.85567144
137MP0009703_decreased_birth_body0.82614658
138MP0000462_abnormal_digestive_system0.82563968
139MP0004142_abnormal_muscle_tone0.79331001
140MP0008058_abnormal_DNA_repair0.79224524
141MP0002108_abnormal_muscle_morphology0.78704019
142MP0002063_abnormal_learning/memory/cond0.78505217

Predicted human phenotypes

RankGene SetZ-score
1Short 4th metacarpal (HP:0010044)4.55374790
2Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)4.55374790
3Cortical dysplasia (HP:0002539)3.67524261
4Abnormality of the 4th metacarpal (HP:0010012)3.66398821
5Oligodactyly (hands) (HP:0001180)3.27220392
6Split foot (HP:0001839)3.20232803
7Intestinal atresia (HP:0011100)3.02744074
8Shallow orbits (HP:0000586)2.89484636
9Renal duplication (HP:0000075)2.78090214
10Aplasia cutis congenita (HP:0001057)2.66064916
11Abnormality of the right ventricle (HP:0001707)2.64969485
12Volvulus (HP:0002580)2.62694069
13Papillary thyroid carcinoma (HP:0002895)2.58561507
14Cutaneous syndactyly (HP:0012725)2.57716819
15Renal hypoplasia (HP:0000089)2.55896527
16Vitreoretinal degeneration (HP:0000655)2.48822128
17Chin dimple (HP:0010751)2.44484081
18Colon cancer (HP:0003003)2.43576067
19Midline defect of the nose (HP:0004122)2.43126348
20Trigonocephaly (HP:0000243)2.41875917
21Large earlobe (HP:0009748)2.40506261
22Spinal cord lesions (HP:0100561)2.37405574
23Syringomyelia (HP:0003396)2.37405574
24Abnormality of the parietal bone (HP:0002696)2.35819251
25Coronal craniosynostosis (HP:0004440)2.35672181
26Down-sloping shoulders (HP:0200021)2.33791085
27Protrusio acetabuli (HP:0003179)2.33107108
28Abnormality of the intervertebral disk (HP:0005108)2.32069252
29Asymmetry of the thorax (HP:0001555)2.31142125
30Increased nuchal translucency (HP:0010880)2.27173312
31Skull defect (HP:0001362)2.26981400
32Genital tract atresia (HP:0001827)2.26024807
33Mesomelia (HP:0003027)2.25013264
34Gait imbalance (HP:0002141)2.24748426
35Subacute progressive viral hepatitis (HP:0006572)2.24283094
36Decreased lacrimation (HP:0000633)2.22285403
37Short middle phalanx of the 5th finger (HP:0004220)2.21304095
38Aortic aneurysm (HP:0004942)2.20425152
39Vaginal atresia (HP:0000148)2.20339379
40Gastrointestinal atresia (HP:0002589)2.18548108
41Supernumerary ribs (HP:0005815)2.17247835
42Congenital primary aphakia (HP:0007707)2.16375931
43Medial flaring of the eyebrow (HP:0010747)2.14406998
44Long eyelashes (HP:0000527)2.14360205
45Morphological abnormality of the middle ear (HP:0008609)2.09209825
46Abnormal number of incisors (HP:0011064)2.08172477
47Megalencephaly (HP:0001355)2.07509747
48Abnormality of the antihelix (HP:0009738)2.07080859
49Medulloblastoma (HP:0002885)2.06235134
50Bicuspid aortic valve (HP:0001647)2.06100035
51Abnormality of the astrocytes (HP:0100707)2.05651300
52Astrocytoma (HP:0009592)2.05651300
53Glioma (HP:0009733)2.05026534
54Alacrima (HP:0000522)2.04908778
55Nephrogenic diabetes insipidus (HP:0009806)2.03124694
56Rhabdomyosarcoma (HP:0002859)2.03102268
57Hypoplastic labia majora (HP:0000059)2.01684815
58Adactyly (HP:0009776)2.00211305
59Abnormality of the labia minora (HP:0012880)1.99966546
60Ectopic kidney (HP:0000086)1.99495496
61Broad foot (HP:0001769)1.99439339
62Chorioretinal atrophy (HP:0000533)1.99278193
63Ankle contracture (HP:0006466)1.99069906
64Hyperacusis (HP:0010780)1.97516481
65Cutis marmorata (HP:0000965)1.97227909
66Neoplasm of striated muscle (HP:0009728)1.96401783
67Narrow palate (HP:0000189)1.96277000
68Short 5th finger (HP:0009237)1.95816973
69White forelock (HP:0002211)1.93975055
70Tented upper lip vermilion (HP:0010804)1.93690596
71Hyperventilation (HP:0002883)1.93667372
72True hermaphroditism (HP:0010459)1.92680770
73Postaxial hand polydactyly (HP:0001162)1.92050457
74Premature rupture of membranes (HP:0001788)1.91479976
75Aortic dissection (HP:0002647)1.91188720
76Abnormality of the diencephalon (HP:0010662)1.90936813
77Tubulointerstitial nephritis (HP:0001970)1.90585705
78Acute lymphatic leukemia (HP:0006721)1.90280123
79Chronic hepatic failure (HP:0100626)1.89232294
80Abnormality of the radial head (HP:0003995)1.88925556
81Macroorchidism (HP:0000053)1.88716472
82Vertebral arch anomaly (HP:0008438)1.88285514
83Limited elbow extension (HP:0001377)1.86728847
84Heterochromia iridis (HP:0001100)1.86246167
85Cupped ear (HP:0000378)1.85523523
86Neoplasm of the oral cavity (HP:0100649)1.85202523
87Supernumerary bones of the axial skeleton (HP:0009144)1.84697750
88Abnormality of the labia majora (HP:0012881)1.84604838
89Broad thumb (HP:0011304)1.84339286
90Retinal dysplasia (HP:0007973)1.82753160
91Broad toe (HP:0001837)1.81434077
92Abnormality of the fingertips (HP:0001211)1.81172965
93Renovascular hypertension (HP:0100817)1.81008046
94Pheochromocytoma (HP:0002666)1.80533146
95Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.80486110
96Patchy hypopigmentation of hair (HP:0011365)1.78825224
97Bladder diverticulum (HP:0000015)1.78268918
98Abnormality of the ischium (HP:0003174)1.78034406
99Drooling (HP:0002307)1.77946964
100Increased number of teeth (HP:0011069)1.77343269
101Proximal placement of thumb (HP:0009623)1.77244853
102Tracheomalacia (HP:0002779)1.77234634
103Abnormality of the phalanges of the 2nd finger (HP:0009541)1.77147784
104Rib fusion (HP:0000902)1.76676032
105Micropenis (HP:0000054)1.76297942
106Exostoses (HP:0100777)1.75955646
107Cutaneous finger syndactyly (HP:0010554)1.75804508
108Broad metatarsal (HP:0001783)1.74153279
109Obsessive-compulsive behavior (HP:0000722)1.74023484
110Poor coordination (HP:0002370)1.73588896
111Aqueductal stenosis (HP:0002410)1.73055487
112Oligodactyly (HP:0012165)1.72993954
113Deviation of the thumb (HP:0009603)1.72870823
114Overriding aorta (HP:0002623)1.72565575
115Flat cornea (HP:0007720)1.72395751
116Fibular hypoplasia (HP:0003038)1.72302993
117Arterial tortuosity (HP:0005116)1.70756628
118Microglossia (HP:0000171)1.69797246
119* Deviation of the hallux (HP:0010051)1.69728584
120Persistence of primary teeth (HP:0006335)1.69645251
121Deep philtrum (HP:0002002)1.69293335
122Bell-shaped thorax (HP:0001591)1.69214355
123Wide anterior fontanel (HP:0000260)1.69050517
124Thyroid carcinoma (HP:0002890)1.68921155
125Aplasia/Hypoplasia of the sternum (HP:0006714)1.68764111
126Intellectual disability, moderate (HP:0002342)1.68525820
127Focal motor seizures (HP:0011153)1.68457615
128High anterior hairline (HP:0009890)1.68140668
129Esophageal atresia (HP:0002032)1.67929437
130Abnormality of the parathyroid morphology (HP:0011766)1.67880850
131Abnormality of the distal phalanx of the thumb (HP:0009617)1.67787479
132Hyperglycinemia (HP:0002154)1.66802122
133Long clavicles (HP:0000890)1.66655784
134Specific learning disability (HP:0001328)1.66543097
135Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.66446453
136Degeneration of the lateral corticospinal tracts (HP:0002314)1.66446453
137Abnormality of the 2nd finger (HP:0004100)1.65139511
138Aplasia/Hypoplasia of the fibula (HP:0006492)1.65111842
139Myelomeningocele (HP:0002475)1.64973355
140Septo-optic dysplasia (HP:0100842)1.64563553
141Postaxial foot polydactyly (HP:0001830)1.64304849
142Mitral regurgitation (HP:0001653)1.63488682
143Hypoplasia of the iris (HP:0007676)1.63396280
144Bifid tongue (HP:0010297)1.63317899
145Patellar dislocation (HP:0002999)1.63149920
146Abnormality of the pubic bones (HP:0003172)1.62645293
147Dislocated radial head (HP:0003083)1.62639586
148Skin tags (HP:0010609)1.62090855
149Anophthalmia (HP:0000528)1.61332705
150Wrist flexion contracture (HP:0001239)1.60733798
151Hemiparesis (HP:0001269)1.60160230
152Lissencephaly (HP:0001339)1.60027658
153Rectal prolapse (HP:0002035)1.59806692
154Vascular tortuosity (HP:0004948)1.59433070
155Atresia of the external auditory canal (HP:0000413)1.59049616
156Hemivertebrae (HP:0002937)1.58381916
157Absent speech (HP:0001344)1.58221382
158Neoplasm of the heart (HP:0100544)1.57927236
159Preaxial foot polydactyly (HP:0001841)1.57777438
160Abnormality of the incisor (HP:0000676)1.57740901
161Broad phalanges of the hand (HP:0009768)1.57145884
162* Hallux valgus (HP:0001822)1.57110548
163Preaxial hand polydactyly (HP:0001177)1.56978924
164Vesicoureteral reflux (HP:0000076)1.56902190
165Gonadotropin excess (HP:0000837)1.56858027
166Blue irides (HP:0000635)1.56594356
167Neonatal short-limb short stature (HP:0008921)1.56301877
168Absent frontal sinuses (HP:0002688)1.56251509
169Buphthalmos (HP:0000557)1.56082644
170Mitral valve prolapse (HP:0001634)1.56064397
171Cerebral aneurysm (HP:0004944)1.55624144
172Synostosis of carpal bones (HP:0005048)1.55535100
173Broad ribs (HP:0000885)1.55379278
174Hypoplasia of the maxilla (HP:0000327)1.54837723
175Abnormality of the nasal septum (HP:0000419)1.54730558
176Smooth philtrum (HP:0000319)1.54699171
177Hepatoblastoma (HP:0002884)1.54040002
178Abnormality of chromosome segregation (HP:0002916)1.53947356

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK14.64221834
2FGFR24.26246911
3CASK3.48999820
4WNK32.99857582
5EPHB22.78261638
6CDK122.68485261
7PDGFRA2.67615688
8MAP3K102.60100523
9MAP3K42.54832083
10PNCK2.44585484
11TYRO32.42382839
12BRD42.40913589
13MAP4K22.35457826
14LATS12.22248270
15MELK2.20533114
16FGFR42.05653356
17EPHA32.03876919
18MKNK12.03833340
19STK38L2.03008074
20TNIK1.98406170
21CDC71.97998016
22DDR21.95809657
23TRIB31.87308103
24MAP2K71.86175511
25FGFR31.81678527
26MAPK131.78754437
27SIK31.75709092
28PASK1.74370656
29WEE11.71890412
30SIK11.71705674
31FGFR11.68774230
32EPHA41.65980698
33DYRK21.64160167
34EEF2K1.58265360
35PDGFRB1.58122528
36BMPR1B1.57832974
37KSR11.57045275
38PTK61.50156638
39CSNK1A1L1.50144404
40BCR1.45949870
41TGFBR11.40809713
42ERBB31.37493853
43DMPK1.37100890
44NTRK21.22985492
45CDK61.22709874
46CDK91.16689456
47DYRK1B1.16669045
48MKNK21.13947922
49PKN11.13148562
50YES11.10192705
51NUAK11.09555128
52ERBB21.08783947
53CHUK1.05715893
54PLK21.03455718
55DYRK31.01435425
56ICK1.01044775
57PBK0.98664271
58STK100.97950653
59LRRK20.97407716
60STK30.97391436
61NTRK30.96322678
62ITK0.95152124
63PKN20.93927236
64CDK30.93736980
65NEK10.93483196
66CSNK1G10.93203611
67CSNK1G30.92919050
68CLK10.88431942
69MTOR0.88352938
70CCNB10.87191397
71CDK80.86331746
72TTN0.85934667
73TRIM280.85557449
74UHMK10.85205231
75PAK40.85160574
76NEK20.84593133
77NEK60.83120348
78SRPK10.82999650
79PAK20.82906758
80IRAK20.82407488
81ATR0.81672207
82BRSK20.80760867
83DYRK1A0.80301180
84CDC42BPA0.79357823
85BMX0.79035223
86EPHB10.78585727
87SGK20.78558042
88NTRK10.78478458
89PAK60.78079435
90TAOK20.77675364
91RPS6KA40.74708840
92PINK10.73037831
93AURKB0.72968818
94CAMK1G0.72747985
95RET0.71609809
96CDK70.71270314
97PLK40.70584301
98EIF2AK30.70089793
99CDK40.69690744
100PLK30.67438336
101BRSK10.65892806
102CHEK10.65650301
103VRK10.65214284
104CAMK1D0.65027438
105SGK2230.63561372
106SGK4940.63561372
107NLK0.63229236
108FRK0.62960535
109ROCK20.61907947
110MAP3K80.61504551
111PRKD30.57878357
112CSNK1G20.57835940
113PRKD10.57724792
114HIPK20.57695089
115INSRR0.57497924
116STK390.56507468
117PRKCE0.56506920
118CDK180.56487883
119ERBB40.56353850
120NEK90.56326536
121CDK150.55091457
122CHEK20.53747103
123CDK140.53725588
124MET0.51763639
125ILK0.51690925
126ADRBK20.51590905
127PLK10.51183776
128ROCK10.51093460
129CDK10.50149519
130CDK11A0.49757237
131FER0.49386941
132TAF10.47774272
133ATM0.47512791
134STK40.45350306
135TTK0.44706859
136MAP2K40.44250704
137CDK50.44085453
138WNK10.43927723
139TSSK60.43843104
140TLK10.43814288
141PAK30.43630609
142AKT20.42893726
143CDK20.42838822
144TGFBR20.41856265
145AKT10.41327807
146ZAK0.41295868
147CSNK1D0.41067130
148RAF10.40029264
149IRAK10.38680273
150BUB10.38142258
151HCK0.37705245
152MAPK110.34952141

Predicted pathways (KEGG)

RankGene SetZ-score
1Basal cell carcinoma_Homo sapiens_hsa052172.95188763
2Notch signaling pathway_Homo sapiens_hsa043302.90600596
3Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.66535003
4Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.44302524
5MicroRNAs in cancer_Homo sapiens_hsa052062.25426902
6Cell cycle_Homo sapiens_hsa041102.20126022
7Hedgehog signaling pathway_Homo sapiens_hsa043402.18134997
8Hippo signaling pathway_Homo sapiens_hsa043902.02230856
9Axon guidance_Homo sapiens_hsa043601.98605555
10Chronic myeloid leukemia_Homo sapiens_hsa052201.94067481
11Adherens junction_Homo sapiens_hsa045201.86062616
12Nicotine addiction_Homo sapiens_hsa050331.81766470
13Spliceosome_Homo sapiens_hsa030401.76533376
14Proteoglycans in cancer_Homo sapiens_hsa052051.76048358
15Propanoate metabolism_Homo sapiens_hsa006401.74675667
16Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.73989899
17mRNA surveillance pathway_Homo sapiens_hsa030151.69680057
18Wnt signaling pathway_Homo sapiens_hsa043101.66009046
19Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.65814871
20Butanoate metabolism_Homo sapiens_hsa006501.61934583
21Small cell lung cancer_Homo sapiens_hsa052221.61927918
22Colorectal cancer_Homo sapiens_hsa052101.60766433
23Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.57065594
24TGF-beta signaling pathway_Homo sapiens_hsa043501.55212690
25Transcriptional misregulation in cancer_Homo sapiens_hsa052021.50952612
26Non-homologous end-joining_Homo sapiens_hsa034501.49542264
27Endometrial cancer_Homo sapiens_hsa052131.48560326
28Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.46857268
29Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.46494761
30Glutamatergic synapse_Homo sapiens_hsa047241.43769264
31ECM-receptor interaction_Homo sapiens_hsa045121.42610537
32Focal adhesion_Homo sapiens_hsa045101.42483409
33HTLV-I infection_Homo sapiens_hsa051661.37633480
34Viral myocarditis_Homo sapiens_hsa054161.37447416
35Pancreatic cancer_Homo sapiens_hsa052121.36900034
36Prostate cancer_Homo sapiens_hsa052151.36494664
37Non-small cell lung cancer_Homo sapiens_hsa052231.35858213
38Circadian entrainment_Homo sapiens_hsa047131.34268662
39T cell receptor signaling pathway_Homo sapiens_hsa046601.33951442
40Dorso-ventral axis formation_Homo sapiens_hsa043201.30197924
41Cocaine addiction_Homo sapiens_hsa050301.29597991
42Protein export_Homo sapiens_hsa030601.29029205
43Dopaminergic synapse_Homo sapiens_hsa047281.27730098
44Lysine degradation_Homo sapiens_hsa003101.26815523
45Pathways in cancer_Homo sapiens_hsa052001.25863693
46Systemic lupus erythematosus_Homo sapiens_hsa053221.19566753
47Steroid biosynthesis_Homo sapiens_hsa001001.19557826
48Glioma_Homo sapiens_hsa052141.19425892
49AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.18818836
50Viral carcinogenesis_Homo sapiens_hsa052031.18712565
51Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.18494427
52Circadian rhythm_Homo sapiens_hsa047101.17459244
53Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.17306551
54GABAergic synapse_Homo sapiens_hsa047271.17055816
55Melanogenesis_Homo sapiens_hsa049161.16697333
56Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.15066922
57Leukocyte transendothelial migration_Homo sapiens_hsa046701.14935189
58Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.13579948
59Hepatitis B_Homo sapiens_hsa051611.12510702
60Renal cell carcinoma_Homo sapiens_hsa052111.11829859
61Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.10508341
62Long-term depression_Homo sapiens_hsa047301.07886557
63Base excision repair_Homo sapiens_hsa034101.07591486
64Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.05258629
65ErbB signaling pathway_Homo sapiens_hsa040121.04450784
66Bladder cancer_Homo sapiens_hsa052191.04014218
67p53 signaling pathway_Homo sapiens_hsa041151.03682088
68Fatty acid metabolism_Homo sapiens_hsa012121.02725942
69Thyroid hormone signaling pathway_Homo sapiens_hsa049191.02553691
70Fanconi anemia pathway_Homo sapiens_hsa034601.01392039
71DNA replication_Homo sapiens_hsa030301.00565091
72Melanoma_Homo sapiens_hsa052180.98817387
73Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.97712616
74Tight junction_Homo sapiens_hsa045300.97023734
75Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.91726349
76PI3K-Akt signaling pathway_Homo sapiens_hsa041510.91187851
77Amphetamine addiction_Homo sapiens_hsa050310.89532310
78Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.88629730
79NF-kappa B signaling pathway_Homo sapiens_hsa040640.86942827
80Neurotrophin signaling pathway_Homo sapiens_hsa047220.85896664
81Measles_Homo sapiens_hsa051620.85328948
82Nucleotide excision repair_Homo sapiens_hsa034200.85180328
83Alcoholism_Homo sapiens_hsa050340.84905986
84Primary immunodeficiency_Homo sapiens_hsa053400.84722111
85Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.84712983
86Nitrogen metabolism_Homo sapiens_hsa009100.84446523
87Taste transduction_Homo sapiens_hsa047420.83178146
88RNA transport_Homo sapiens_hsa030130.81714447
89Rap1 signaling pathway_Homo sapiens_hsa040150.81180548
90Thyroid cancer_Homo sapiens_hsa052160.80682344
91Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.80671197
92mTOR signaling pathway_Homo sapiens_hsa041500.79740469
93Herpes simplex infection_Homo sapiens_hsa051680.79341338
94Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.77735615
95Regulation of actin cytoskeleton_Homo sapiens_hsa048100.77328223
96Cholinergic synapse_Homo sapiens_hsa047250.76926275
97FoxO signaling pathway_Homo sapiens_hsa040680.75917274
98B cell receptor signaling pathway_Homo sapiens_hsa046620.72561727
99Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.72530779
100Toxoplasmosis_Homo sapiens_hsa051450.72502747
101Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.72473916
102Epstein-Barr virus infection_Homo sapiens_hsa051690.71308716
103Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.70267323
104Morphine addiction_Homo sapiens_hsa050320.69950744
105cAMP signaling pathway_Homo sapiens_hsa040240.69822515
106Homologous recombination_Homo sapiens_hsa034400.66018729
107Platelet activation_Homo sapiens_hsa046110.65812285
108Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.64916401
109Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.64657762
110Choline metabolism in cancer_Homo sapiens_hsa052310.64111824
111VEGF signaling pathway_Homo sapiens_hsa043700.63903940
112Shigellosis_Homo sapiens_hsa051310.63390416
113Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.62422378
114Oocyte meiosis_Homo sapiens_hsa041140.60406110
115Acute myeloid leukemia_Homo sapiens_hsa052210.59054581
116Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.58609954
117Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.56583235
118Estrogen signaling pathway_Homo sapiens_hsa049150.56284107
119Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.55918709
120Phototransduction_Homo sapiens_hsa047440.55450168
121Protein digestion and absorption_Homo sapiens_hsa049740.54714915
122Serotonergic synapse_Homo sapiens_hsa047260.53839575
123Gap junction_Homo sapiens_hsa045400.51309989
124RNA degradation_Homo sapiens_hsa030180.50602257
125TNF signaling pathway_Homo sapiens_hsa046680.50594831
126Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.50380445
127Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.50252369
128Central carbon metabolism in cancer_Homo sapiens_hsa052300.49575503
1292-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.49342323
130Basal transcription factors_Homo sapiens_hsa030220.48465642
131Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.48410310
132Mismatch repair_Homo sapiens_hsa034300.47644186
133Ras signaling pathway_Homo sapiens_hsa040140.46649387
134Chemokine signaling pathway_Homo sapiens_hsa040620.46479342
135Phospholipase D signaling pathway_Homo sapiens_hsa040720.46300267
136Gastric acid secretion_Homo sapiens_hsa049710.43856255
137Apoptosis_Homo sapiens_hsa042100.43624954
138Dilated cardiomyopathy_Homo sapiens_hsa054140.42659373
139Amoebiasis_Homo sapiens_hsa051460.42633394
140Osteoclast differentiation_Homo sapiens_hsa043800.42498744
141Olfactory transduction_Homo sapiens_hsa047400.42057115
142MAPK signaling pathway_Homo sapiens_hsa040100.42008035
143Prolactin signaling pathway_Homo sapiens_hsa049170.41777124
144Fatty acid elongation_Homo sapiens_hsa000620.40971753

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