TCEB1P31

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1monocyte chemotaxis (GO:0002548)6.01556638
2DNA deamination (GO:0045006)5.46896871
3negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)5.37611409
4negative regulation of T-helper cell differentiation (GO:0045623)5.37611409
5negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)4.68336785
6water-soluble vitamin biosynthetic process (GO:0042364)4.63776923
7regulation of immunoglobulin secretion (GO:0051023)4.58577719
8regulation of T cell chemotaxis (GO:0010819)4.47716741
9positive regulation of T cell chemotaxis (GO:0010820)4.47716741
10negative regulation of alpha-beta T cell differentiation (GO:0046639)4.20178043
11proteasome assembly (GO:0043248)4.14475122
12cytidine metabolic process (GO:0046087)4.09950328
13cytidine catabolic process (GO:0006216)4.09950328
14cytidine deamination (GO:0009972)4.09950328
15nucleotide transmembrane transport (GO:1901679)4.08008400
16regulation of chronic inflammatory response (GO:0002676)4.03694011
17regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.94469817
18rRNA modification (GO:0000154)3.89926427
19pseudouridine synthesis (GO:0001522)3.79447567
20AMP metabolic process (GO:0046033)3.77793247
21establishment of protein localization to mitochondrial membrane (GO:0090151)3.77685950
22platelet dense granule organization (GO:0060155)3.75830123
23rRNA methylation (GO:0031167)3.73750971
24chaperone-mediated protein transport (GO:0072321)3.70286249
25histone mRNA metabolic process (GO:0008334)3.65225894
26DNA double-strand break processing (GO:0000729)3.62798735
27pyrimidine ribonucleoside catabolic process (GO:0046133)3.61321262
28eosinophil chemotaxis (GO:0048245)3.57905723
29fucose catabolic process (GO:0019317)3.57617632
30L-fucose metabolic process (GO:0042354)3.57617632
31L-fucose catabolic process (GO:0042355)3.57617632
32C-terminal protein lipidation (GO:0006501)3.51428799
33forebrain neuron differentiation (GO:0021879)3.47969123
34interferon-gamma production (GO:0032609)3.41398095
35IMP metabolic process (GO:0046040)3.40862124
36cellular response to interleukin-15 (GO:0071350)3.39585454
37negative regulation of T cell differentiation (GO:0045581)3.39348220
38positive regulation of granulocyte differentiation (GO:0030854)3.37416843
39signal peptide processing (GO:0006465)3.36813952
40mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.32291065
41CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)3.24383868
42T-helper cell differentiation (GO:0042093)3.24383868
43eosinophil migration (GO:0072677)3.22270138
44preassembly of GPI anchor in ER membrane (GO:0016254)3.21157193
45positive regulation of mitochondrial fission (GO:0090141)3.18968426
46positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)3.17829490
47regulation of isotype switching to IgG isotypes (GO:0048302)3.11443285
48positive regulation of prostaglandin secretion (GO:0032308)3.06831009
49negative regulation of alpha-beta T cell activation (GO:0046636)3.06629195
50positive regulation of natural killer cell mediated immunity (GO:0002717)3.03394950
51metallo-sulfur cluster assembly (GO:0031163)3.02845966
52iron-sulfur cluster assembly (GO:0016226)3.02845966
53protein K6-linked ubiquitination (GO:0085020)3.01033242
54response to interleukin-15 (GO:0070672)2.97972422
55ribosome assembly (GO:0042255)2.95525603
56mannosylation (GO:0097502)2.94337968
57regulation of T cell receptor signaling pathway (GO:0050856)2.90366017
58T cell differentiation involved in immune response (GO:0002292)2.89977707
59alpha-beta T cell differentiation involved in immune response (GO:0002293)2.89977707
60alpha-beta T cell activation involved in immune response (GO:0002287)2.89977707
61GPI anchor biosynthetic process (GO:0006506)2.88757360
62C-terminal protein amino acid modification (GO:0018410)2.88697563
63histone mRNA catabolic process (GO:0071044)2.85668278
64double-strand break repair via homologous recombination (GO:0000724)2.84359656
65somatic hypermutation of immunoglobulin genes (GO:0016446)2.83814930
66somatic diversification of immune receptors via somatic mutation (GO:0002566)2.83814930
67positive regulation of fatty acid transport (GO:2000193)2.83085009
68DNA catabolic process, exonucleolytic (GO:0000738)2.83051327
69GPI anchor metabolic process (GO:0006505)2.82903127
70positive regulation of T cell cytokine production (GO:0002726)2.81071368
71branched-chain amino acid catabolic process (GO:0009083)2.80684979
72protein neddylation (GO:0045116)2.79656013
73recombinational repair (GO:0000725)2.78512280
74electron transport chain (GO:0022900)2.73905271
75adaptation of signaling pathway (GO:0023058)2.73241388
76nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.72772420
77respiratory electron transport chain (GO:0022904)2.72651053
78hypothalamus development (GO:0021854)2.71344451
79positive regulation of protein homodimerization activity (GO:0090073)2.69639363
80S-adenosylmethionine metabolic process (GO:0046500)2.67827428
81negative regulation of B cell proliferation (GO:0030889)2.67448613
82positive regulation of heat generation (GO:0031652)2.67277016
83exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.66788151
84termination of RNA polymerase III transcription (GO:0006386)2.66549974
85transcription elongation from RNA polymerase III promoter (GO:0006385)2.66549974
86GTP biosynthetic process (GO:0006183)2.62686550
87protein targeting to mitochondrion (GO:0006626)2.62310068
88protein complex biogenesis (GO:0070271)2.59700021
89negative regulation of lymphocyte differentiation (GO:0045620)2.59033202
90regulation of regulatory T cell differentiation (GO:0045589)2.55839200
91negative regulation of B cell activation (GO:0050869)2.55580581
92positive regulation of protein sumoylation (GO:0033235)2.55534275
93negative regulation of T cell receptor signaling pathway (GO:0050860)2.54648188
94negative regulation of mast cell activation (GO:0033004)2.54465447
95establishment of protein localization to mitochondrion (GO:0072655)2.53961415
96positive regulation of icosanoid secretion (GO:0032305)2.53847065
97regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.47791535
98tyrosine phosphorylation of STAT protein (GO:0007260)2.47526862
99mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.45946080
100positive regulation of translational initiation (GO:0045948)2.45063396

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GABP_17652178_ChIP-ChIP_JURKAT_Human4.37811981
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.92332445
3FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.77834986
4E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.50946144
5EST1_17652178_ChIP-ChIP_JURKAT_Human3.34302268
6NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.98283510
7VDR_23849224_ChIP-Seq_CD4+_Human2.91378407
8GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.81470063
9HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.80816038
10VDR_22108803_ChIP-Seq_LS180_Human2.67362099
11ELK1_19687146_ChIP-ChIP_HELA_Human2.55753614
12FLI1_27457419_Chip-Seq_LIVER_Mouse2.49617814
13FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.38706882
14SALL1_21062744_ChIP-ChIP_HESCs_Human2.36516959
15JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.32678976
16ETS1_20019798_ChIP-Seq_JURKAT_Human2.31124685
17DMRT1_21621532_ChIP-ChIP_FETAL_Ovary2.23873278
18ZNF274_21170338_ChIP-Seq_K562_Hela2.22258042
19MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.18997331
20TAF15_26573619_Chip-Seq_HEK293_Human2.15980391
21POU3F2_20337985_ChIP-ChIP_501MEL_Human2.10679455
22PCGF2_27294783_Chip-Seq_ESCs_Mouse2.03966147
23NOTCH1_21737748_ChIP-Seq_TLL_Human2.03853783
24STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.02851481
25FOXP3_21729870_ChIP-Seq_TREG_Human1.90311755
26PCGF2_27294783_Chip-Seq_NPCs_Mouse1.82744588
27DCP1A_22483619_ChIP-Seq_HELA_Human1.80787729
28CREB1_15753290_ChIP-ChIP_HEK293T_Human1.77044229
29SUZ12_27294783_Chip-Seq_NPCs_Mouse1.76012883
30FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.73112921
31EWS_26573619_Chip-Seq_HEK293_Human1.69373320
32IRF1_19129219_ChIP-ChIP_H3396_Human1.67117445
33EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.66447961
34E2F4_17652178_ChIP-ChIP_JURKAT_Human1.61590365
35PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.60332606
36ER_23166858_ChIP-Seq_MCF-7_Human1.57842275
37IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.54700316
38PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.54494796
39EZH2_27294783_Chip-Seq_NPCs_Mouse1.50533016
40NFE2_27457419_Chip-Seq_LIVER_Mouse1.49714595
41PADI4_21655091_ChIP-ChIP_MCF-7_Human1.48483423
42SRF_21415370_ChIP-Seq_HL-1_Mouse1.47375480
43CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.46864226
44ELK1_22589737_ChIP-Seq_MCF10A_Human1.39187853
45CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.38163206
46YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.37208890
47CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.34946557
48IGF1R_20145208_ChIP-Seq_DFB_Human1.34077469
49HOXB4_20404135_ChIP-ChIP_EML_Mouse1.32335666
50TP53_22573176_ChIP-Seq_HFKS_Human1.31873009
51FUS_26573619_Chip-Seq_HEK293_Human1.26107903
52MYC_18940864_ChIP-ChIP_HL60_Human1.25046081
53P300_19829295_ChIP-Seq_ESCs_Human1.23866567
54CRX_20693478_ChIP-Seq_RETINA_Mouse1.20356167
55CTBP1_25329375_ChIP-Seq_LNCAP_Human1.20160537
56CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.15441646
57MYC_18555785_ChIP-Seq_MESCs_Mouse1.11973933
58ELF1_17652178_ChIP-ChIP_JURKAT_Human1.11875721
59ZFP57_27257070_Chip-Seq_ESCs_Mouse1.10466808
60NCOR_22424771_ChIP-Seq_293T_Human1.09299219
61CBP_20019798_ChIP-Seq_JUKART_Human1.07096185
62IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.07096185
63CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.04722645
64CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.04705271
65HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.04648272
66THAP11_20581084_ChIP-Seq_MESCs_Mouse1.03622565
67MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.02531726
68RBPJ_21746931_ChIP-Seq_IB4_Human1.02095007
69CTBP2_25329375_ChIP-Seq_LNCAP_Human1.01749858
70ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.01356091
71SOX2_19829295_ChIP-Seq_ESCs_Human1.01026230
72NANOG_19829295_ChIP-Seq_ESCs_Human1.01026230
73MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.00579161
74MYB_26560356_Chip-Seq_TH2_Human0.99544132
75GATA3_26560356_Chip-Seq_TH2_Human0.97536385
76HOXB7_26014856_ChIP-Seq_BT474_Human0.97439728
77PHF8_20622853_ChIP-Seq_HELA_Human0.97338036
78KDM5A_27292631_Chip-Seq_BREAST_Human0.97107808
79CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.97035725
80MYC_19030024_ChIP-ChIP_MESCs_Mouse0.95641593
81AR_20517297_ChIP-Seq_VCAP_Human0.95353992
82SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.95313945
83GATA6_21074721_ChIP-Seq_CACO-2_Human0.93986844
84GATA3_26560356_Chip-Seq_TH1_Human0.93421472
85P53_22387025_ChIP-Seq_ESCs_Mouse0.93347050
86GABP_19822575_ChIP-Seq_HepG2_Human0.93324796
87FOXA1_27270436_Chip-Seq_PROSTATE_Human0.93124850
88FOXA1_25329375_ChIP-Seq_VCAP_Human0.93124850
89PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.92823679
90GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.92804268
91TP53_16413492_ChIP-PET_HCT116_Human0.92775177
92OCT4_21477851_ChIP-Seq_ESCs_Mouse0.92756490
93GATA3_27048872_Chip-Seq_THYMUS_Human0.90903531
94STAT3_18555785_Chip-Seq_ESCs_Mouse0.90478448
95TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.89945696
96GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.89053250
97EGR1_23403033_ChIP-Seq_LIVER_Mouse0.88921858
98HNFA_21074721_ChIP-Seq_CACO-2_Human0.88913564
99NFYB_21822215_ChIP-Seq_K562_Human0.88589254
100P300_18555785_Chip-Seq_ESCs_Mouse0.88306541

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001873_stomach_inflammation4.38450387
2MP0005645_abnormal_hypothalamus_physiol4.02344749
3MP0003195_calcinosis3.13769458
4MP0003880_abnormal_central_pattern3.03668750
5MP0005379_endocrine/exocrine_gland_phen2.82770725
6MP0005671_abnormal_response_to2.82219169
7MP0003787_abnormal_imprinting2.73791162
8MP0003763_abnormal_thymus_physiology2.68456603
9MP0003786_premature_aging2.58075507
10MP0008058_abnormal_DNA_repair2.46640814
11MP0005167_abnormal_blood-brain_barrier2.46050969
12MP0008875_abnormal_xenobiotic_pharmacok2.38916129
13MP0002653_abnormal_ependyma_morphology2.37511645
14MP0006072_abnormal_retinal_apoptosis2.30075908
15MP0003011_delayed_dark_adaptation2.29689255
16MP0005075_abnormal_melanosome_morpholog2.21382343
17MP0006082_CNS_inflammation2.12219024
18MP0005310_abnormal_salivary_gland2.10698555
19MP0008877_abnormal_DNA_methylation1.94365991
20MP0006292_abnormal_olfactory_placode1.92585629
21MP0002138_abnormal_hepatobiliary_system1.87094785
22MP0009333_abnormal_splenocyte_physiolog1.84731824
23MP0006276_abnormal_autonomic_nervous1.78499347
24MP0000685_abnormal_immune_system1.78446399
25MP0005423_abnormal_somatic_nervous1.78005603
26MP0004147_increased_porphyrin_level1.67537716
27MP0002163_abnormal_gland_morphology1.66876562
28MP0005646_abnormal_pituitary_gland1.66533132
29MP0001188_hyperpigmentation1.62369888
30MP0001984_abnormal_olfaction1.59763556
31MP0002254_reproductive_system_inflammat1.58217261
32MP0004145_abnormal_muscle_electrophysio1.56474117
33MP0002638_abnormal_pupillary_reflex1.49783122
34MP0004142_abnormal_muscle_tone1.48735257
35MP0004381_abnormal_hair_follicle1.45479491
36MP0003693_abnormal_embryo_hatching1.43663874
37MP0002751_abnormal_autonomic_nervous1.42298523
38MP0001905_abnormal_dopamine_level1.38776232
39MP0001348_abnormal_lacrimal_gland1.37416012
40MP0002234_abnormal_pharynx_morphology1.34272772
41MP0005253_abnormal_eye_physiology1.32416914
42MP0001790_abnormal_immune_system1.31104925
43MP0005387_immune_system_phenotype1.31104925
44MP0001800_abnormal_humoral_immune1.26009502
45MP0008872_abnormal_physiological_respon1.24666205
46MP0003718_maternal_effect1.22727985
47MP0003121_genomic_imprinting1.16248617
48MP0005083_abnormal_biliary_tract1.15416620
49MP0000639_abnormal_adrenal_gland1.14908705
50MP0000372_irregular_coat_pigmentation1.14518075
51MP0005551_abnormal_eye_electrophysiolog1.11476270
52MP0002909_abnormal_adrenal_gland1.10624406
53MP0001764_abnormal_homeostasis1.07074004
54MP0003866_abnormal_defecation1.05506399
55MP0000689_abnormal_spleen_morphology1.04571289
56MP0000703_abnormal_thymus_morphology1.02673105
57MP0010094_abnormal_chromosome_stability1.00906124
58MP0001853_heart_inflammation0.99766377
59MP0000631_abnormal_neuroendocrine_gland0.99749008
60MP0005647_abnormal_sex_gland0.93970049
61MP0009384_cardiac_valve_regurgitation0.93267027
62MP0006036_abnormal_mitochondrial_physio0.92432272
63MP0002160_abnormal_reproductive_system0.91776277
64MP0003045_fibrosis0.91402916
65MP0002723_abnormal_immune_serum0.90103719
66MP0002148_abnormal_hypersensitivity_rea0.89835633
67MP0002277_abnormal_respiratory_mucosa0.89609897
68MP0004133_heterotaxia0.89367237
69MP0002405_respiratory_system_inflammati0.89340127
70MP0005389_reproductive_system_phenotype0.89092216
71MP0002693_abnormal_pancreas_physiology0.89086475
72MP0000613_abnormal_salivary_gland0.88621131
73MP0003122_maternal_imprinting0.87274398
74MP0002090_abnormal_vision0.87114506
75MP0002876_abnormal_thyroid_physiology0.84575262
76MP0001835_abnormal_antigen_presentation0.83630735
77MP0005410_abnormal_fertilization0.82179685
78MP0003567_abnormal_fetal_cardiomyocyte0.81988724
79MP0009046_muscle_twitch0.81611813
80MP0005636_abnormal_mineral_homeostasis0.80942058
81MP0000647_abnormal_sebaceous_gland0.77889445
82MP0002398_abnormal_bone_marrow0.75247897
83MP0004957_abnormal_blastocyst_morpholog0.72923084
84MP0001919_abnormal_reproductive_system0.72467307
85MP0001819_abnormal_immune_cell0.72440944
86MP0002420_abnormal_adaptive_immunity0.71829890
87MP0001986_abnormal_taste_sensitivity0.69745140
88MP0002452_abnormal_antigen_presenting0.69410955
89MP0003936_abnormal_reproductive_system0.69236109
90MP0005395_other_phenotype0.68267419
91MP0000716_abnormal_immune_system0.67816265
92MP0002722_abnormal_immune_system0.67693156
93MP0005332_abnormal_amino_acid0.67358379
94MP0001968_abnormal_touch/_nociception0.67235740
95MP0003806_abnormal_nucleotide_metabolis0.64772167
96MP0010307_abnormal_tumor_latency0.64691588
97MP0005084_abnormal_gallbladder_morpholo0.63658833
98MP0004215_abnormal_myocardial_fiber0.63423517
99MP0004885_abnormal_endolymph0.63403818
100MP0001944_abnormal_pancreas_morphology0.63329497

Predicted human phenotypes

RankGene SetZ-score
1Increased hepatocellular lipid droplets (HP:0006565)4.21466258
2Lipid accumulation in hepatocytes (HP:0006561)4.01731351
3Thyroiditis (HP:0100646)3.92917192
4Severe combined immunodeficiency (HP:0004430)3.87698734
5Molar tooth sign on MRI (HP:0002419)3.69456129
6Abnormality of midbrain morphology (HP:0002418)3.69456129
7IgG deficiency (HP:0004315)3.63975936
83-Methylglutaconic aciduria (HP:0003535)3.57354135
9Acute necrotizing encephalopathy (HP:0006965)3.31633349
10Mitochondrial inheritance (HP:0001427)3.29995432
11Homocystinuria (HP:0002156)3.27390343
12Abnormality of homocysteine metabolism (HP:0010919)3.27390343
13T lymphocytopenia (HP:0005403)3.24357072
14Abnormality of methionine metabolism (HP:0010901)3.19337802
15Chronic mucocutaneous candidiasis (HP:0002728)3.18740211
16Recurrent cutaneous fungal infections (HP:0011370)3.18740211
17Abnormality of aspartate family amino acid metabolism (HP:0010899)3.15429313
18Renal Fanconi syndrome (HP:0001994)3.14190532
19Stomatitis (HP:0010280)3.14065788
20Methylmalonic acidemia (HP:0002912)3.10745126
21Acute encephalopathy (HP:0006846)3.09301902
22Methylmalonic aciduria (HP:0012120)3.03787160
23Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.00746507
24Combined immunodeficiency (HP:0005387)2.95174761
25Hypoalbuminemia (HP:0003073)2.93911191
26Abnormal albumin level (HP:0012116)2.93911191
27Increased CSF lactate (HP:0002490)2.92084509
28Hypoplasia of the thymus (HP:0000778)2.88606317
29Abnormality of T cell number (HP:0011839)2.87063519
30Progressive macrocephaly (HP:0004481)2.86080756
31Abnormality of vitamin B metabolism (HP:0004340)2.85668236
32Hypoproteinemia (HP:0003075)2.81638326
33Abnormal mitochondria in muscle tissue (HP:0008316)2.73770297
34Abnormality of the vitamin B12 metabolism (HP:0004341)2.68505441
35Hepatocellular necrosis (HP:0001404)2.52193840
36Elevated erythrocyte sedimentation rate (HP:0003565)2.51217653
37Neonatal respiratory distress (HP:0002643)2.50579293
38Congenital, generalized hypertrichosis (HP:0004540)2.50419205
39Abolished electroretinogram (ERG) (HP:0000550)2.46950811
40Abnormality of eosinophils (HP:0001879)2.44729259
41Hypothermia (HP:0002045)2.43808983
42Cerebral edema (HP:0002181)2.43286638
43Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.42104704
44Exertional dyspnea (HP:0002875)2.41901671
45Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.40547053
46Decreased activity of mitochondrial respiratory chain (HP:0008972)2.40547053
47Pigmentary retinal degeneration (HP:0001146)2.39733575
48Menstrual irregularities (HP:0000858)2.37723927
49Ependymoma (HP:0002888)2.37576170
50Microvesicular hepatic steatosis (HP:0001414)2.37013852
51Tubular atrophy (HP:0000092)2.32992355
52Abnormality of sulfur amino acid metabolism (HP:0004339)2.31102486
53Nephronophthisis (HP:0000090)2.27830910
54Medial flaring of the eyebrow (HP:0010747)2.27436034
55Increased intramyocellular lipid droplets (HP:0012240)2.27346686
56Aplasia/Hypoplasia involving the musculature (HP:0001460)2.24400662
57Tongue fasciculations (HP:0001308)2.23292827
58Agitation (HP:0000713)2.20109081
59Type I transferrin isoform profile (HP:0003642)2.19592248
60Increased serum lactate (HP:0002151)2.18808545
61Large for gestational age (HP:0001520)2.15593346
62Testicular atrophy (HP:0000029)2.14816226
63Abnormality of aromatic amino acid family metabolism (HP:0004338)2.13380153
64Polydipsia (HP:0001959)2.07054729
65Abnormal drinking behavior (HP:0030082)2.07054729
66Abnormality of the prostate (HP:0008775)2.06361551
67Hepatic necrosis (HP:0002605)2.06049502
68Pendular nystagmus (HP:0012043)2.02802819
69Pancreatic cysts (HP:0001737)2.02682991
70Pancytopenia (HP:0001876)2.00577497
71Astrocytoma (HP:0009592)2.00051704
72Abnormality of the astrocytes (HP:0100707)2.00051704
73Adrenal hypoplasia (HP:0000835)1.98551508
74Abnormality of T cells (HP:0002843)1.98542167
75Bile duct proliferation (HP:0001408)1.95431639
76Abnormal biliary tract physiology (HP:0012439)1.95431639
77Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.93797524
78Abnormal protein N-linked glycosylation (HP:0012347)1.93797524
79Abnormal protein glycosylation (HP:0012346)1.93797524
80Abnormal glycosylation (HP:0012345)1.93797524
81Degeneration of anterior horn cells (HP:0002398)1.93149513
82Abnormality of the anterior horn cell (HP:0006802)1.93149513
83Aplastic anemia (HP:0001915)1.93072152
84Bifid tongue (HP:0010297)1.92939895
85Resting tremor (HP:0002322)1.92182735
86Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.91386590
87Dicarboxylic aciduria (HP:0003215)1.90651222
88Abnormality of dicarboxylic acid metabolism (HP:0010995)1.90651222
89Increased muscle lipid content (HP:0009058)1.88515068
90Lactic acidosis (HP:0003128)1.87642357
91Abnormality of the renal medulla (HP:0100957)1.87278480
92True hermaphroditism (HP:0010459)1.84817058
93Respiratory difficulties (HP:0002880)1.83120431
94Abnormality of the labia minora (HP:0012880)1.82297528
95Abnormality of renal resorption (HP:0011038)1.81744933
96Megaloblastic anemia (HP:0001889)1.78662205
97Lethargy (HP:0001254)1.77540118
98Muscle fibrillation (HP:0010546)1.77107908
99Abnormality of serum amino acid levels (HP:0003112)1.76256675
100IgM deficiency (HP:0002850)1.76062869

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PBK4.32872712
2TXK4.26216285
3EPHA33.21374738
4NLK3.18266378
5NUAK13.16838637
6EIF2AK33.04461044
7TSSK62.84693452
8FRK2.71282771
9MST42.44214399
10IRAK22.36042164
11CCNB12.24695530
12IRAK12.13878218
13SRPK12.13061733
14MAP3K92.10963313
15VRK22.03834077
16NME11.83351848
17MAPKAPK31.80485638
18ADRBK21.72764333
19FES1.71824390
20FER1.69950853
21TRIM281.64896031
22TEC1.53772606
23ITK1.48095766
24IKBKE1.41788862
25TNK21.38410370
26NEK11.34630987
27WNK31.31544074
28IKBKB1.31436594
29VRK11.30217035
30CSNK1G11.28164401
31BMPR1B1.27470696
32CAMKK21.27188227
33PLK41.18433539
34GRK11.17522837
35BUB11.17269221
36PLK21.08185984
37PINK11.05332628
38WNK41.04865304
39LIMK11.01348446
40DMPK0.99260464
41PLK30.97445827
42BCR0.90904658
43STK160.90610319
44CSNK1G30.81715156
45FGR0.78722152
46ZAK0.76876340
47EIF2AK20.75635340
48STK30.73012287
49DYRK20.71598853
50EIF2AK10.71583503
51PRKCG0.67489436
52CSNK1G20.64595922
53CSNK1A1L0.63340983
54MAP4K20.63340701
55ALK0.63224102
56TIE10.63136783
57LMTK20.58565596
58TAOK10.57491885
59TLK10.57273310
60AKT30.56591599
61MAP3K40.56358486
62PHKG10.53475512
63PHKG20.53475512
64SCYL20.53065344
65ATR0.52932584
66CAMK2A0.50826530
67TNIK0.49567505
68STK110.49307585
69PTK2B0.49007541
70ACVR1B0.48122600
71LATS10.45692513
72CHUK0.45441871
73BMPR20.44859139
74BTK0.43476191
75LCK0.43112565
76TBK10.42048050
77IRAK40.41564708
78INSRR0.40398498
79STK38L0.36872130
80MARK30.36721057
81MKNK10.36207040
82BCKDK0.33899993
83MAP2K70.32104845
84MKNK20.31577055
85PIK3CG0.31094509
86FGFR20.29955180
87PRKCQ0.29873018
88UHMK10.29329880
89CSNK2A10.27562393
90MATK0.26547518
91CSNK1A10.26352027
92PRKG10.26324610
93PRKCI0.25657137
94DAPK10.25117028
95MAP3K120.24225130
96MAPK130.23743795
97CAMK40.23613041
98GSK3A0.22944493
99CAMK10.21882451
100TAF10.21567442

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005633.78194319
2Protein export_Homo sapiens_hsa030603.61761517
3Proteasome_Homo sapiens_hsa030503.45008429
4Oxidative phosphorylation_Homo sapiens_hsa001903.41267641
5Primary immunodeficiency_Homo sapiens_hsa053402.95221107
6Parkinsons disease_Homo sapiens_hsa050122.60138040
7Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.47572663
8Propanoate metabolism_Homo sapiens_hsa006402.45441168
9RNA polymerase_Homo sapiens_hsa030202.25126923
10Homologous recombination_Homo sapiens_hsa034402.22361842
11Autoimmune thyroid disease_Homo sapiens_hsa053202.19902761
12Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.17771174
13Fanconi anemia pathway_Homo sapiens_hsa034602.16751618
14Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.97803114
15Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.92955177
16Allograft rejection_Homo sapiens_hsa053301.75900271
17Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.69951598
18Basal transcription factors_Homo sapiens_hsa030221.64238446
19Mismatch repair_Homo sapiens_hsa034301.56866577
20Folate biosynthesis_Homo sapiens_hsa007901.54973751
21Huntingtons disease_Homo sapiens_hsa050161.54578458
22Alzheimers disease_Homo sapiens_hsa050101.48309616
23RNA degradation_Homo sapiens_hsa030181.44649017
24T cell receptor signaling pathway_Homo sapiens_hsa046601.42791270
25Ribosome_Homo sapiens_hsa030101.37816216
26Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.35937785
27Fatty acid elongation_Homo sapiens_hsa000621.33497859
28Asthma_Homo sapiens_hsa053101.29840849
29Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.29458112
30Purine metabolism_Homo sapiens_hsa002301.28475439
31Spliceosome_Homo sapiens_hsa030401.24249475
32Linoleic acid metabolism_Homo sapiens_hsa005911.21424445
33Intestinal immune network for IgA production_Homo sapiens_hsa046721.17870311
34Nitrogen metabolism_Homo sapiens_hsa009101.16191239
35Nucleotide excision repair_Homo sapiens_hsa034201.15916311
36Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.15111304
37RNA transport_Homo sapiens_hsa030131.13142951
38Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.12545904
39Non-homologous end-joining_Homo sapiens_hsa034501.11904156
40Vitamin B6 metabolism_Homo sapiens_hsa007501.10186365
41Collecting duct acid secretion_Homo sapiens_hsa049661.09436186
42Glycosaminoglycan degradation_Homo sapiens_hsa005311.09387427
43Cardiac muscle contraction_Homo sapiens_hsa042601.07523342
44Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.04065321
45Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.03708193
46alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.99958385
47Graft-versus-host disease_Homo sapiens_hsa053320.94532865
48Phototransduction_Homo sapiens_hsa047440.93276392
49Butanoate metabolism_Homo sapiens_hsa006500.92665722
50Pyrimidine metabolism_Homo sapiens_hsa002400.92219136
51Sulfur metabolism_Homo sapiens_hsa009200.91753857
52Cysteine and methionine metabolism_Homo sapiens_hsa002700.89228502
53Sulfur relay system_Homo sapiens_hsa041220.88423611
54beta-Alanine metabolism_Homo sapiens_hsa004100.83768632
55Type I diabetes mellitus_Homo sapiens_hsa049400.82274628
56Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.80110026
57Antigen processing and presentation_Homo sapiens_hsa046120.78569964
58Hematopoietic cell lineage_Homo sapiens_hsa046400.78427432
59Measles_Homo sapiens_hsa051620.77232833
60Fatty acid degradation_Homo sapiens_hsa000710.73346825
61Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.72877045
62Regulation of autophagy_Homo sapiens_hsa041400.71574699
63Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.71349725
64Tryptophan metabolism_Homo sapiens_hsa003800.68903828
65Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.68725104
66Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.67991866
67Peroxisome_Homo sapiens_hsa041460.66942228
68Metabolic pathways_Homo sapiens_hsa011000.65728009
69Maturity onset diabetes of the young_Homo sapiens_hsa049500.64449465
70Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.63222884
71Fatty acid metabolism_Homo sapiens_hsa012120.60271076
72Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.60168645
73Rheumatoid arthritis_Homo sapiens_hsa053230.58592980
74N-Glycan biosynthesis_Homo sapiens_hsa005100.57683470
75NOD-like receptor signaling pathway_Homo sapiens_hsa046210.56846845
76Steroid biosynthesis_Homo sapiens_hsa001000.56417339
77Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.55821094
78Morphine addiction_Homo sapiens_hsa050320.55361502
79mRNA surveillance pathway_Homo sapiens_hsa030150.55306653
80Selenocompound metabolism_Homo sapiens_hsa004500.48855323
81Pyruvate metabolism_Homo sapiens_hsa006200.48660914
82Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.47407093
83Retinol metabolism_Homo sapiens_hsa008300.44726808
84Systemic lupus erythematosus_Homo sapiens_hsa053220.42509720
85Caffeine metabolism_Homo sapiens_hsa002320.42459952
86Chemical carcinogenesis_Homo sapiens_hsa052040.41482167
87SNARE interactions in vesicular transport_Homo sapiens_hsa041300.41363519
88Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.41051155
89Chemokine signaling pathway_Homo sapiens_hsa040620.40499550
90Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.39916307
91Ether lipid metabolism_Homo sapiens_hsa005650.39230875
92Steroid hormone biosynthesis_Homo sapiens_hsa001400.38658992
93Jak-STAT signaling pathway_Homo sapiens_hsa046300.37540361
94Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.36619139
95Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.35422152
96Arachidonic acid metabolism_Homo sapiens_hsa005900.32853956
97Serotonergic synapse_Homo sapiens_hsa047260.31463823
98Dorso-ventral axis formation_Homo sapiens_hsa043200.30996186
99Epstein-Barr virus infection_Homo sapiens_hsa051690.26949466
100One carbon pool by folate_Homo sapiens_hsa006700.26664755

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