TCEAL2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the transcription elongation factor A (SII)-like (TCEAL) gene family. Members of this family contain TFA domains and may function as nuclear phosphoproteins that modulate transcription in a promoter context-dependent manner. Multiple family members are located on the X chromosome. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle maturation (GO:0016188)6.37076028
2glutamate secretion (GO:0014047)5.79629535
3synaptic vesicle docking involved in exocytosis (GO:0016081)5.55326794
4regulation of short-term neuronal synaptic plasticity (GO:0048172)5.41739853
5synaptic vesicle exocytosis (GO:0016079)5.35311516
6positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.16348243
7positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.05010792
8regulation of synaptic vesicle exocytosis (GO:2000300)5.02941365
9membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.95566980
10neurotransmitter secretion (GO:0007269)4.79614689
11neuron cell-cell adhesion (GO:0007158)4.59639545
12ionotropic glutamate receptor signaling pathway (GO:0035235)4.58468709
13postsynaptic membrane organization (GO:0001941)4.52538399
14regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.50957375
15regulation of synaptic vesicle transport (GO:1902803)4.45112690
16vocalization behavior (GO:0071625)4.35009986
17cellular potassium ion homeostasis (GO:0030007)4.30703847
18positive regulation of synaptic transmission, dopaminergic (GO:0032226)4.29276227
19synaptic transmission, glutamatergic (GO:0035249)4.25590751
20presynaptic membrane assembly (GO:0097105)4.24744467
21gamma-aminobutyric acid transport (GO:0015812)4.21949535
22protein localization to synapse (GO:0035418)4.14783348
23dendritic spine morphogenesis (GO:0060997)4.13552992
24locomotory exploration behavior (GO:0035641)4.09666752
25presynaptic membrane organization (GO:0097090)4.09357329
26pyrimidine nucleobase catabolic process (GO:0006208)4.01783183
27regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.99321487
28neuronal action potential propagation (GO:0019227)3.99037145
29neuron-neuron synaptic transmission (GO:0007270)3.98618836
30exploration behavior (GO:0035640)3.97570746
31establishment of mitochondrion localization (GO:0051654)3.96001410
32regulation of glutamate receptor signaling pathway (GO:1900449)3.87255809
33negative regulation of synaptic transmission, GABAergic (GO:0032229)3.85556105
34glutamate receptor signaling pathway (GO:0007215)3.85046476
35neurotransmitter transport (GO:0006836)3.79066673
36regulation of neuronal synaptic plasticity (GO:0048168)3.78965187
37neurotransmitter-gated ion channel clustering (GO:0072578)3.77370769
38transmission of nerve impulse (GO:0019226)3.69894295
39positive regulation of synapse maturation (GO:0090129)3.62768467
40regulation of synapse structural plasticity (GO:0051823)3.62462181
41positive regulation of membrane potential (GO:0045838)3.60609601
42regulation of neurotransmitter levels (GO:0001505)3.58265212
43regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.57252601
44nucleobase catabolic process (GO:0046113)3.56810193
45regulation of excitatory postsynaptic membrane potential (GO:0060079)3.52741617
46neuron recognition (GO:0008038)3.52333324
47axonal fasciculation (GO:0007413)3.49817877
48neuronal ion channel clustering (GO:0045161)3.48417287
49regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.46206739
50regulation of postsynaptic membrane potential (GO:0060078)3.44779029
51positive regulation of neurotransmitter transport (GO:0051590)3.41768804
52regulation of neurotransmitter secretion (GO:0046928)3.40506510
53regulation of voltage-gated calcium channel activity (GO:1901385)3.39654111
54central nervous system myelination (GO:0022010)3.39291889
55axon ensheathment in central nervous system (GO:0032291)3.39291889
56regulation of long-term neuronal synaptic plasticity (GO:0048169)3.37598645
57auditory behavior (GO:0031223)3.37254387
58positive regulation of dendritic spine development (GO:0060999)3.36645117
59potassium ion homeostasis (GO:0055075)3.34600033
60cerebellar granule cell differentiation (GO:0021707)3.33767258
61neurofilament cytoskeleton organization (GO:0060052)3.29893900
62mitochondrion transport along microtubule (GO:0047497)3.27466314
63establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.27466314
64behavioral response to cocaine (GO:0048148)3.25301040
65regulation of vesicle fusion (GO:0031338)3.24706114
66regulation of neurotransmitter transport (GO:0051588)3.22840053
67detection of calcium ion (GO:0005513)3.22710527
68membrane hyperpolarization (GO:0060081)3.21540493
69membrane depolarization during action potential (GO:0086010)3.20937308
70neuromuscular process controlling posture (GO:0050884)3.19944973
71gamma-aminobutyric acid signaling pathway (GO:0007214)3.17779828
72membrane depolarization (GO:0051899)3.13135146
73neuromuscular synaptic transmission (GO:0007274)3.11953443
74proline transport (GO:0015824)3.09196144
75sodium ion export (GO:0071436)3.08230859
76L-amino acid import (GO:0043092)3.07881460
77startle response (GO:0001964)3.07753772
78synaptic vesicle endocytosis (GO:0048488)3.04803773
79positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.03401769
80cell migration in hindbrain (GO:0021535)3.02569120
81adult walking behavior (GO:0007628)3.02457399
82synapse assembly (GO:0007416)3.01820158
83regulation of synapse maturation (GO:0090128)3.01720562
84synaptic transmission (GO:0007268)3.01298985
85cerebellar Purkinje cell differentiation (GO:0021702)2.98779588
86mechanosensory behavior (GO:0007638)2.97091219
87behavioral defense response (GO:0002209)2.92589573
88behavioral fear response (GO:0001662)2.92589573
89regulation of dendritic spine morphogenesis (GO:0061001)2.92401730
90layer formation in cerebral cortex (GO:0021819)2.92342229
91response to auditory stimulus (GO:0010996)2.91333679
92chemosensory behavior (GO:0007635)2.90680689
93positive regulation of dendritic spine morphogenesis (GO:0061003)2.89664514
94potassium ion import (GO:0010107)2.89384809
95regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.89197276
96regulation of neurotransmitter uptake (GO:0051580)2.87287019
97response to histamine (GO:0034776)2.87178379
98regulation of synaptic plasticity (GO:0048167)2.86479038
99regulation of synaptic transmission, glutamatergic (GO:0051966)2.85743569
100cerebellar Purkinje cell layer development (GO:0021680)2.85321567

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.37755760
2NR4A2_19515692_ChIP-ChIP_MN9D_Mouse4.21271449
3REST_21632747_ChIP-Seq_MESCs_Mouse3.27530776
4GBX2_23144817_ChIP-Seq_PC3_Human3.13570588
5SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.82524185
6JARID2_20064375_ChIP-Seq_MESCs_Mouse2.81437932
7EZH2_27304074_Chip-Seq_ESCs_Mouse2.67948370
8CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.66290353
9REST_18959480_ChIP-ChIP_MESCs_Mouse2.65509259
10ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.63107843
11SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.54694813
12JARID2_20075857_ChIP-Seq_MESCs_Mouse2.36591908
13SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.35579076
14SUZ12_27294783_Chip-Seq_ESCs_Mouse2.26699752
15EZH2_27294783_Chip-Seq_ESCs_Mouse2.25708782
16EZH2_18974828_ChIP-Seq_MESCs_Mouse2.25359802
17RNF2_18974828_ChIP-Seq_MESCs_Mouse2.25359802
18RARB_27405468_Chip-Seq_BRAIN_Mouse2.25342673
19RNF2_27304074_Chip-Seq_ESCs_Mouse2.23762361
20SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.21560154
21SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.21483715
22DROSHA_22980978_ChIP-Seq_HELA_Human2.18208614
23EED_16625203_ChIP-ChIP_MESCs_Mouse2.18020381
24TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.17847136
25MTF2_20144788_ChIP-Seq_MESCs_Mouse2.14148864
26SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.07570320
27ZFP57_27257070_Chip-Seq_ESCs_Mouse2.07269749
28TAF15_26573619_Chip-Seq_HEK293_Human1.90866036
29GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.89126954
30CBX2_27304074_Chip-Seq_ESCs_Mouse1.87676281
31RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.85470813
32CTBP2_25329375_ChIP-Seq_LNCAP_Human1.81651311
33RNF2_27304074_Chip-Seq_NSC_Mouse1.75901141
34IKZF1_21737484_ChIP-ChIP_HCT116_Human1.68691092
35BMI1_23680149_ChIP-Seq_NPCS_Mouse1.67029900
36SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.66216453
37RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.65390955
38CTBP1_25329375_ChIP-Seq_LNCAP_Human1.62770306
39SMAD4_21799915_ChIP-Seq_A2780_Human1.46285984
40RING1B_27294783_Chip-Seq_ESCs_Mouse1.44039402
41P300_19829295_ChIP-Seq_ESCs_Human1.40954813
42SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.38015697
43EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.36487739
44IGF1R_20145208_ChIP-Seq_DFB_Human1.31630898
45PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.31348382
46RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.31295604
47GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.30093706
48PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.29969872
49MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.29676181
50NR3C1_23031785_ChIP-Seq_PC12_Mouse1.27626473
51SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.24450554
52E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.24358508
53SMAD3_21741376_ChIP-Seq_EPCs_Human1.24002299
54AR_21572438_ChIP-Seq_LNCaP_Human1.23960470
55POU3F2_20337985_ChIP-ChIP_501MEL_Human1.23715529
56OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.23443999
57ERG_21242973_ChIP-ChIP_JURKAT_Human1.23348396
58TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.20927111
59SOX2_21211035_ChIP-Seq_LN229_Gbm1.19457470
60AR_25329375_ChIP-Seq_VCAP_Human1.18032709
61PIAS1_25552417_ChIP-Seq_VCAP_Human1.16453543
62ZNF274_21170338_ChIP-Seq_K562_Hela1.15799931
63TOP2B_26459242_ChIP-Seq_MCF-7_Human1.15106630
64CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.12614572
65TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.11160513
66FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.10384118
67POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.10081655
68TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10081655
69AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.08088603
70AR_19668381_ChIP-Seq_PC3_Human1.08005473
71TCF4_23295773_ChIP-Seq_U87_Human1.07608684
72FUS_26573619_Chip-Seq_HEK293_Human1.07360134
73MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.06868023
74HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.05770153
75STAT3_23295773_ChIP-Seq_U87_Human1.05204383
76VDR_22108803_ChIP-Seq_LS180_Human1.04626401
77MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.02924090
78P53_22127205_ChIP-Seq_FIBROBLAST_Human1.02909075
79WT1_25993318_ChIP-Seq_PODOCYTE_Human1.02334931
80OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.01459873
81SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.99619204
82LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99264191
83JUN_21703547_ChIP-Seq_K562_Human0.98656974
84UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.98399919
85RUNX2_22187159_ChIP-Seq_PCA_Human0.97713757
86KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.97295232
87SMAD3_21741376_ChIP-Seq_ESCs_Human0.96929575
88RING1B_27294783_Chip-Seq_NPCs_Mouse0.95782135
89ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.95501496
90CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94671387
91MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.94427035
92NANOG_18555785_Chip-Seq_ESCs_Mouse0.92828031
93TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.91366046
94SOX9_26525672_Chip-Seq_HEART_Mouse0.90229767
95DNAJC2_21179169_ChIP-ChIP_NT2_Human0.90024674
96GATA1_26923725_Chip-Seq_HPCs_Mouse0.89201390
97YAP1_20516196_ChIP-Seq_MESCs_Mouse0.89125654
98GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.87496529
99TAL1_26923725_Chip-Seq_HPCs_Mouse0.86655308
100ETV2_25802403_ChIP-Seq_MESCs_Mouse0.83921442

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.18952088
2MP0003880_abnormal_central_pattern4.05242096
3MP0004270_analgesia3.97201087
4MP0003635_abnormal_synaptic_transmissio3.46967693
5MP0005423_abnormal_somatic_nervous3.14118899
6MP0002064_seizures3.08322985
7MP0009745_abnormal_behavioral_response3.06343646
8MP0003787_abnormal_imprinting2.97936660
9MP0002272_abnormal_nervous_system2.87462086
10MP0009046_muscle_twitch2.85781308
11MP0002063_abnormal_learning/memory/cond2.83263583
12MP0002734_abnormal_mechanical_nocicepti2.65861602
13MP0001968_abnormal_touch/_nociception2.62801352
14MP0003122_maternal_imprinting2.61155237
15MP0002572_abnormal_emotion/affect_behav2.51322229
16MP0001486_abnormal_startle_reflex2.49025768
17MP0002736_abnormal_nociception_after2.16382022
18MP0002735_abnormal_chemical_nociception2.14606379
19MP0008877_abnormal_DNA_methylation2.06079192
20MP0000778_abnormal_nervous_system2.03092772
21MP0001984_abnormal_olfaction2.02605183
22MP0001970_abnormal_pain_threshold2.01330758
23MP0004885_abnormal_endolymph2.01246383
24MP0002733_abnormal_thermal_nociception1.96670480
25MP0006276_abnormal_autonomic_nervous1.91630183
26MP0002557_abnormal_social/conspecific_i1.81174732
27MP0003879_abnormal_hair_cell1.77983728
28MP0002067_abnormal_sensory_capabilities1.77809753
29MP0001501_abnormal_sleep_pattern1.77567396
30MP0003121_genomic_imprinting1.72036988
31MP0001440_abnormal_grooming_behavior1.64169222
32MP0008569_lethality_at_weaning1.62131930
33MP0004811_abnormal_neuron_physiology1.61999729
34MP0000955_abnormal_spinal_cord1.61143009
35MP0001188_hyperpigmentation1.60384222
36MP0001905_abnormal_dopamine_level1.55595677
37MP0005646_abnormal_pituitary_gland1.54904838
38MP0003123_paternal_imprinting1.54144236
39MP0002638_abnormal_pupillary_reflex1.51033105
40MP0004742_abnormal_vestibular_system1.50991697
41MP0002822_catalepsy1.50064306
42MP0004924_abnormal_behavior1.49092874
43MP0005386_behavior/neurological_phenoty1.49092874
44MP0002882_abnormal_neuron_morphology1.49088676
45MP0001502_abnormal_circadian_rhythm1.48402639
46MP0005551_abnormal_eye_electrophysiolog1.45469422
47MP0003329_amyloid_beta_deposits1.45167572
48MP0004142_abnormal_muscle_tone1.45108568
49MP0001529_abnormal_vocalization1.40195562
50MP0002909_abnormal_adrenal_gland1.38492135
51MP0002184_abnormal_innervation1.38215836
52MP0002066_abnormal_motor_capabilities/c1.37050271
53MP0009780_abnormal_chondrocyte_physiolo1.36854187
54MP0005645_abnormal_hypothalamus_physiol1.33378551
55MP0003633_abnormal_nervous_system1.31631493
56MP0001485_abnormal_pinna_reflex1.30969767
57MP0002152_abnormal_brain_morphology1.16404940
58MP0002229_neurodegeneration1.14561786
59MP0003631_nervous_system_phenotype1.12524489
60MP0001963_abnormal_hearing_physiology1.08522667
61MP0010386_abnormal_urinary_bladder1.05795691
62MP0006072_abnormal_retinal_apoptosis1.03088710
63MP0002752_abnormal_somatic_nervous0.99044592
64MP0000631_abnormal_neuroendocrine_gland0.98993621
65MP0003690_abnormal_glial_cell0.98953593
66MP0004133_heterotaxia0.97258824
67MP0003283_abnormal_digestive_organ0.96110759
68MP0006292_abnormal_olfactory_placode0.94323282
69MP0002069_abnormal_eating/drinking_beha0.92230783
70MP0001986_abnormal_taste_sensitivity0.88216429
71MP0005499_abnormal_olfactory_system0.88110129
72MP0005394_taste/olfaction_phenotype0.88110129
73MP0003632_abnormal_nervous_system0.86415413
74MP0000920_abnormal_myelination0.86001264
75MP0002837_dystrophic_cardiac_calcinosis0.85364891
76MP0001177_atelectasis0.83320427
77MP0004147_increased_porphyrin_level0.81751353
78MP0000026_abnormal_inner_ear0.81545187
79MP0005253_abnormal_eye_physiology0.80282341
80MP0003634_abnormal_glial_cell0.77828582
81MP0002653_abnormal_ependyma_morphology0.77645426
82MP0008872_abnormal_physiological_respon0.77367602
83MP0003861_abnormal_nervous_system0.72571206
84MP0003890_abnormal_embryonic-extraembry0.70693635
85MP0003136_yellow_coat_color0.69524270
86MP0000566_synostosis0.68756946
87MP0003137_abnormal_impulse_conducting0.68128697
88MP0004043_abnormal_pH_regulation0.64274558
89MP0005535_abnormal_body_temperature0.63869213
90MP0002102_abnormal_ear_morphology0.63602608
91MP0003938_abnormal_ear_development0.62160370
92MP0004085_abnormal_heartbeat0.60292684
93MP0002090_abnormal_vision0.60196074
94MP0002082_postnatal_lethality0.57809878
95MP0010770_preweaning_lethality0.57809878
96MP0005379_endocrine/exocrine_gland_phen0.57014466
97MP0003011_delayed_dark_adaptation0.56245216
98MP0010769_abnormal_survival0.56210540
99MP0001299_abnormal_eye_distance/0.56205918
100MP0005195_abnormal_posterior_eye0.56145270

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)7.05513662
2Focal motor seizures (HP:0011153)5.78803701
3Focal seizures (HP:0007359)5.26057812
4Epileptic encephalopathy (HP:0200134)4.75190233
5Febrile seizures (HP:0002373)4.54917362
6Limb dystonia (HP:0002451)4.44988145
7Atonic seizures (HP:0010819)4.25273703
8Action tremor (HP:0002345)4.20218302
9Generalized tonic-clonic seizures (HP:0002069)3.88193970
10Progressive cerebellar ataxia (HP:0002073)3.76633644
11Dialeptic seizures (HP:0011146)3.73456919
12Absence seizures (HP:0002121)3.65150779
13Polyphagia (HP:0002591)3.60834431
14Abnormal eating behavior (HP:0100738)3.58346924
15Diplopia (HP:0000651)3.50204455
16Abnormality of binocular vision (HP:0011514)3.50204455
17Epileptiform EEG discharges (HP:0011182)3.47365945
18EEG with generalized epileptiform discharges (HP:0011198)3.23997984
19Hemiparesis (HP:0001269)3.16145982
20Sleep apnea (HP:0010535)3.12027577
21Hypsarrhythmia (HP:0002521)3.06332253
22Broad-based gait (HP:0002136)2.90946988
23Supranuclear gaze palsy (HP:0000605)2.89715360
24Abnormality of the labia minora (HP:0012880)2.89684677
25Gait imbalance (HP:0002141)2.88111710
26Papilledema (HP:0001085)2.85320167
27Drooling (HP:0002307)2.80335983
28Ankle clonus (HP:0011448)2.78392893
29Hyperventilation (HP:0002883)2.77670823
30Mutism (HP:0002300)2.75856501
31Status epilepticus (HP:0002133)2.64938870
32Abnormality of the corticospinal tract (HP:0002492)2.63784641
33Impaired vibration sensation in the lower limbs (HP:0002166)2.56466100
34Excessive salivation (HP:0003781)2.55338310
35Spastic gait (HP:0002064)2.53882927
36Poor suck (HP:0002033)2.52956646
37Visual hallucinations (HP:0002367)2.52686067
38Intention tremor (HP:0002080)2.51671865
39Cerebral hypomyelination (HP:0006808)2.50280633
40Anxiety (HP:0000739)2.49461453
41Amblyopia (HP:0000646)2.48136701
42Agitation (HP:0000713)2.44870144
43Neurofibrillary tangles (HP:0002185)2.43594631
44Torticollis (HP:0000473)2.43231264
45Fetal akinesia sequence (HP:0001989)2.40069952
46Urinary bladder sphincter dysfunction (HP:0002839)2.38223687
47Failure to thrive in infancy (HP:0001531)2.36748972
48Poor eye contact (HP:0000817)2.34350022
49Akinesia (HP:0002304)2.27599399
50Medial flaring of the eyebrow (HP:0010747)2.25455447
51Focal dystonia (HP:0004373)2.24404926
52Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.23912793
53Degeneration of the lateral corticospinal tracts (HP:0002314)2.23912793
54Spastic tetraplegia (HP:0002510)2.23580240
55Urinary urgency (HP:0000012)2.23254103
56Specific learning disability (HP:0001328)2.20837396
57Truncal ataxia (HP:0002078)2.19204234
58Dysmetria (HP:0001310)2.17067910
59Megalencephaly (HP:0001355)2.13286969
60Absent speech (HP:0001344)2.11425166
61Peripheral hypomyelination (HP:0007182)2.09494247
62Congenital primary aphakia (HP:0007707)2.08667269
63Dysdiadochokinesis (HP:0002075)2.08060873
64Gaze-evoked nystagmus (HP:0000640)2.07986661
65Esotropia (HP:0000565)2.06718950
66Impaired social interactions (HP:0000735)2.04674119
67Abnormal social behavior (HP:0012433)2.04674119
68Postural instability (HP:0002172)2.03128561
69Nephrogenic diabetes insipidus (HP:0009806)2.03000261
70Morphological abnormality of the pyramidal tract (HP:0002062)2.02757127
71Bradykinesia (HP:0002067)1.97456405
72Progressive macrocephaly (HP:0004481)1.96767942
73Hemiplegia (HP:0002301)1.93558978
74Increased circulating renin level (HP:0000848)1.92395942
75Delusions (HP:0000746)1.90736507
76Muscular hypotonia of the trunk (HP:0008936)1.88941607
77Oligodactyly (hands) (HP:0001180)1.88883733
78Craniofacial dystonia (HP:0012179)1.88579320
79CNS hypomyelination (HP:0003429)1.88407202
80Acute necrotizing encephalopathy (HP:0006965)1.83937311
81Genetic anticipation (HP:0003743)1.83638425
82Genital tract atresia (HP:0001827)1.81914409
83Optic nerve hypoplasia (HP:0000609)1.80981822
84Depression (HP:0000716)1.79477808
85Vaginal atresia (HP:0000148)1.78823034
86Generalized myoclonic seizures (HP:0002123)1.77530113
87Spastic tetraparesis (HP:0001285)1.76455989
88Inability to walk (HP:0002540)1.76412287
89Lissencephaly (HP:0001339)1.75770095
90Amyotrophic lateral sclerosis (HP:0007354)1.75570880
91Abnormality of midbrain morphology (HP:0002418)1.74690924
92Molar tooth sign on MRI (HP:0002419)1.74690924
93Impaired smooth pursuit (HP:0007772)1.74496215
94Restlessness (HP:0000711)1.74166327
95Pachygyria (HP:0001302)1.73170254
96Choreoathetosis (HP:0001266)1.72954265
97Hypoplasia of the corpus callosum (HP:0002079)1.71680488
98Cerebral inclusion bodies (HP:0100314)1.71012401
99Incomplete penetrance (HP:0003829)1.70069238
100Split foot (HP:0001839)1.69973486

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK14.87280505
2CASK3.93581693
3EPHA43.53012307
4NTRK33.42740255
5DAPK22.79762776
6NTRK22.60409143
7UHMK12.56761320
8PAK62.56098268
9STK162.44000441
10MINK12.27861737
11MAPK132.21488273
12SIK22.08484796
13MAP3K42.02932850
14WNK32.00215015
15PINK11.96136537
16MAP3K91.88296393
17PRKD31.86487806
18PAK31.82879118
19CDK191.77337841
20TNIK1.74001720
21PRKCG1.71456921
22PHKG11.69228245
23PHKG21.69228245
24DYRK21.62854516
25PLK21.59940446
26MAP2K71.57533094
27CDK51.42417652
28SGK4941.42395880
29SGK2231.42395880
30FRK1.32262713
31CAMKK11.32253639
32NTRK11.30366054
33CSNK1G21.22392454
34PNCK1.10818697
35CAMK2B1.07815448
36CAMK11.05998735
37CAMK2A1.04498402
38DYRK1A1.01669930
39TYRO30.98942647
40OXSR10.97912112
41MAP2K40.97344173
42SGK20.97276315
43GRK50.96334149
44PKN10.94957490
45CDK140.91840366
46CDK150.90025078
47CDK180.88892442
48STK110.87956407
49FGFR20.86364862
50MAP4K20.85155248
51DAPK10.84997105
52PRKCH0.82339362
53SGK10.82123071
54CDK11A0.81838195
55CSNK1G30.77360311
56PRPF4B0.75726767
57MARK20.71664354
58CAMK2G0.70676185
59BCR0.70603101
60CSNK1G10.69993404
61PRKCZ0.69440110
62DMPK0.68470366
63CAMKK20.67385317
64PRKCE0.66921200
65WNK40.66912347
66CSNK1E0.62657839
67CAMK2D0.60953402
68ALK0.59736667
69ARAF0.58213680
70MAPK120.58090774
71CSNK1A1L0.56055615
72RPS6KA30.53221885
73STK380.51115534
74LATS20.51040613
75PRKG10.49620786
76TAOK20.49472505
77CSNK1A10.49396977
78GRK10.48057540
79SGK30.46762864
80PRKACA0.45698577
81CSNK1D0.43677494
82CDK30.42458749
83CAMK40.41925326
84LIMK10.41290440
85MAPK100.39680243
86ADRBK20.39243608
87PRKCA0.38874451
88MKNK20.37904599
89BMPR1B0.36824755
90PRKDC0.35039382
91MAP3K120.34292156
92TRIM280.33973634
93CAMK1G0.32984261
94MAPKAPK50.32591066
95PLK30.32243193
96PRKAA10.31571379
97INSRR0.31345304
98MAP2K60.30819138
99PRKCB0.29320240
100GSK3B0.28608453

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.80197961
2Synaptic vesicle cycle_Homo sapiens_hsa047213.72349709
3GABAergic synapse_Homo sapiens_hsa047273.07227695
4Morphine addiction_Homo sapiens_hsa050322.73766465
5Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.71566188
6Circadian entrainment_Homo sapiens_hsa047132.70425321
7Insulin secretion_Homo sapiens_hsa049112.65629990
8Glutamatergic synapse_Homo sapiens_hsa047242.61677094
9Amphetamine addiction_Homo sapiens_hsa050312.52249683
10Dopaminergic synapse_Homo sapiens_hsa047282.39454517
11Long-term potentiation_Homo sapiens_hsa047202.09723176
12Cocaine addiction_Homo sapiens_hsa050302.06956453
13Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.87039089
14Cardiac muscle contraction_Homo sapiens_hsa042601.78471106
15Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.75963297
16Gastric acid secretion_Homo sapiens_hsa049711.72788789
17Oxidative phosphorylation_Homo sapiens_hsa001901.72693498
18Cholinergic synapse_Homo sapiens_hsa047251.68928739
19Collecting duct acid secretion_Homo sapiens_hsa049661.67038967
20Taste transduction_Homo sapiens_hsa047421.63002228
21Phototransduction_Homo sapiens_hsa047441.53409341
22Salivary secretion_Homo sapiens_hsa049701.52628499
23Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.52065254
24Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.51308806
25Aldosterone synthesis and secretion_Homo sapiens_hsa049251.48553485
26Long-term depression_Homo sapiens_hsa047301.45860498
27Serotonergic synapse_Homo sapiens_hsa047261.45533044
28Oxytocin signaling pathway_Homo sapiens_hsa049211.40025652
29Parkinsons disease_Homo sapiens_hsa050121.35979264
30Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.35621017
31Renin secretion_Homo sapiens_hsa049241.35450286
32Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.32284909
33cAMP signaling pathway_Homo sapiens_hsa040241.30653537
34Alzheimers disease_Homo sapiens_hsa050101.25502908
35Vitamin B6 metabolism_Homo sapiens_hsa007501.25465174
36Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.19674985
37Calcium signaling pathway_Homo sapiens_hsa040201.19110415
38Olfactory transduction_Homo sapiens_hsa047401.13172704
39Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.10205393
40Butanoate metabolism_Homo sapiens_hsa006501.09865739
41Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.09830957
42Axon guidance_Homo sapiens_hsa043601.01347074
43Gap junction_Homo sapiens_hsa045400.99988621
44Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.97792978
45Melanogenesis_Homo sapiens_hsa049160.82711571
46Oocyte meiosis_Homo sapiens_hsa041140.82600907
47Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.81268061
48Vibrio cholerae infection_Homo sapiens_hsa051100.79644513
49Pancreatic secretion_Homo sapiens_hsa049720.79537670
50Type II diabetes mellitus_Homo sapiens_hsa049300.79330236
51GnRH signaling pathway_Homo sapiens_hsa049120.78990422
52Protein export_Homo sapiens_hsa030600.78203252
53Estrogen signaling pathway_Homo sapiens_hsa049150.77688197
54Circadian rhythm_Homo sapiens_hsa047100.77609868
55Huntingtons disease_Homo sapiens_hsa050160.75520033
56Bile secretion_Homo sapiens_hsa049760.74124725
57Maturity onset diabetes of the young_Homo sapiens_hsa049500.73547028
58cGMP-PKG signaling pathway_Homo sapiens_hsa040220.72870066
59Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.70904758
60Thyroid hormone synthesis_Homo sapiens_hsa049180.63253266
61Dorso-ventral axis formation_Homo sapiens_hsa043200.62264657
62Folate biosynthesis_Homo sapiens_hsa007900.60747912
63Phosphatidylinositol signaling system_Homo sapiens_hsa040700.60435844
64beta-Alanine metabolism_Homo sapiens_hsa004100.59813630
65Vascular smooth muscle contraction_Homo sapiens_hsa042700.59709711
66Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.57874373
67Carbohydrate digestion and absorption_Homo sapiens_hsa049730.57599835
68Ras signaling pathway_Homo sapiens_hsa040140.57007927
69Regulation of autophagy_Homo sapiens_hsa041400.56072687
70ErbB signaling pathway_Homo sapiens_hsa040120.55221432
71Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.54814849
72Glucagon signaling pathway_Homo sapiens_hsa049220.51347619
73Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.50714950
74MAPK signaling pathway_Homo sapiens_hsa040100.46802983
75Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.46032927
76Rap1 signaling pathway_Homo sapiens_hsa040150.45576270
77Alcoholism_Homo sapiens_hsa050340.44336602
78Arginine and proline metabolism_Homo sapiens_hsa003300.42425993
79Ether lipid metabolism_Homo sapiens_hsa005650.42103038
80Wnt signaling pathway_Homo sapiens_hsa043100.39844788
81Glioma_Homo sapiens_hsa052140.38773290
82Phospholipase D signaling pathway_Homo sapiens_hsa040720.38648890
83Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.37280432
84Dilated cardiomyopathy_Homo sapiens_hsa054140.36261324
85Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.35833360
86Ovarian steroidogenesis_Homo sapiens_hsa049130.35642769
87Hippo signaling pathway_Homo sapiens_hsa043900.32530354
88Histidine metabolism_Homo sapiens_hsa003400.32127920
89Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.30330377
90Tight junction_Homo sapiens_hsa045300.29834976
91Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.29706824
92Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.29109101
93Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.28745076
94Prion diseases_Homo sapiens_hsa050200.28631181
95SNARE interactions in vesicular transport_Homo sapiens_hsa041300.27782978
96Nitrogen metabolism_Homo sapiens_hsa009100.27358884
97Mineral absorption_Homo sapiens_hsa049780.27099424
98Arginine biosynthesis_Homo sapiens_hsa002200.25600829
99Hedgehog signaling pathway_Homo sapiens_hsa043400.24568013
100Inositol phosphate metabolism_Homo sapiens_hsa005620.24557744

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