TBXA2R

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the G protein-coupled receptor family. The protein interacts with thromboxane A2 to induce platelet aggregation and regulate hemostasis. A mutation in this gene results in a bleeding disorder. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)6.75193080
2viral transcription (GO:0019083)6.12585321
3antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)6.05111305
4antigen processing and presentation of endogenous peptide antigen (GO:0002483)6.05111305
5translational termination (GO:0006415)5.84966137
6behavioral response to nicotine (GO:0035095)5.68698212
7positive regulation of gamma-delta T cell activation (GO:0046645)5.57975968
8positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)5.48631293
9fucose catabolic process (GO:0019317)5.19834023
10L-fucose metabolic process (GO:0042354)5.19834023
11L-fucose catabolic process (GO:0042355)5.19834023
12translational elongation (GO:0006414)5.09300603
13antigen processing and presentation of endogenous antigen (GO:0019883)5.01971987
14ribosomal small subunit biogenesis (GO:0042274)4.95932158
15SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.85296757
16regulation of gamma-delta T cell differentiation (GO:0045586)4.75490316
17cotranslational protein targeting to membrane (GO:0006613)4.72868540
18protein targeting to ER (GO:0045047)4.71118824
19viral life cycle (GO:0019058)4.56436459
20response to interleukin-15 (GO:0070672)4.51111951
21nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.48534582
22establishment of protein localization to endoplasmic reticulum (GO:0072599)4.47944858
23protein localization to endoplasmic reticulum (GO:0070972)4.45202899
24cellular protein complex disassembly (GO:0043624)4.36756068
25response to pheromone (GO:0019236)4.34746177
26positive regulation of B cell differentiation (GO:0045579)4.30832395
27maturation of SSU-rRNA (GO:0030490)4.27104310
28negative regulation of erythrocyte differentiation (GO:0045647)4.25151654
29regulation of memory T cell differentiation (GO:0043380)4.17365848
30regulation of gamma-delta T cell activation (GO:0046643)4.17196964
31mast cell activation (GO:0045576)4.06868310
32regulation of B cell differentiation (GO:0045577)4.04063295
33translational initiation (GO:0006413)4.00121194
34antigen processing and presentation via MHC class Ib (GO:0002475)3.99576989
35T cell homeostasis (GO:0043029)3.93832092
36protein complex disassembly (GO:0043241)3.93284003
37platelet dense granule organization (GO:0060155)3.88296753
38mast cell degranulation (GO:0043303)3.81121708
39mast cell activation involved in immune response (GO:0002279)3.81121708
40lymphoid progenitor cell differentiation (GO:0002320)3.80031153
41antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.76489236
42protein neddylation (GO:0045116)3.64169188
43macromolecular complex disassembly (GO:0032984)3.59736682
44detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.58640000
45cellular response to interleukin-15 (GO:0071350)3.53814380
46lymph node development (GO:0048535)3.46021137
47mature B cell differentiation involved in immune response (GO:0002313)3.45679257
48detection of light stimulus involved in visual perception (GO:0050908)3.43809803
49detection of light stimulus involved in sensory perception (GO:0050962)3.43809803
50protein complex biogenesis (GO:0070271)3.43623155
51mitochondrial respiratory chain complex I assembly (GO:0032981)3.43452813
52NADH dehydrogenase complex assembly (GO:0010257)3.43452813
53mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.43452813
54positive regulation of defense response to virus by host (GO:0002230)3.42291685
55regulation of interleukin-12 biosynthetic process (GO:0045075)3.41931705
56cellular ketone body metabolic process (GO:0046950)3.39524432
57regulation of T cell receptor signaling pathway (GO:0050856)3.39478648
58definitive hemopoiesis (GO:0060216)3.36399877
59phosphatidylinositol acyl-chain remodeling (GO:0036149)3.35407214
60mucosal-associated lymphoid tissue development (GO:0048537)3.35062111
61Peyers patch development (GO:0048541)3.35062111
62DNA deamination (GO:0045006)3.34781149
63B cell receptor signaling pathway (GO:0050853)3.31601819
64negative T cell selection (GO:0043383)3.29643258
65sulfation (GO:0051923)3.28623457
66nuclear-transcribed mRNA catabolic process (GO:0000956)3.28468566
67response to interferon-beta (GO:0035456)3.28313118
68leukocyte homeostasis (GO:0001776)3.27634999
69response to type I interferon (GO:0034340)3.26722292
70regulation of B cell receptor signaling pathway (GO:0050855)3.25727474
71type I interferon signaling pathway (GO:0060337)3.24033683
72cellular response to type I interferon (GO:0071357)3.24033683
73negative regulation of glycoprotein biosynthetic process (GO:0010561)3.23753521
74regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.23736294
75regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.22504806
76Arp2/3 complex-mediated actin nucleation (GO:0034314)3.21577562
77negative regulation of telomere maintenance (GO:0032205)3.21187268
78NIK/NF-kappaB signaling (GO:0038061)3.21038778
79piRNA metabolic process (GO:0034587)3.20219961
80thrombin receptor signaling pathway (GO:0070493)3.18763666
81protein targeting to membrane (GO:0006612)3.16015326
82purinergic nucleotide receptor signaling pathway (GO:0035590)3.15970813
83preassembly of GPI anchor in ER membrane (GO:0016254)3.15875412
84respiratory chain complex IV assembly (GO:0008535)3.12866506
85mRNA catabolic process (GO:0006402)3.12579329
86mitochondrial respiratory chain complex assembly (GO:0033108)3.12418795
87indolalkylamine metabolic process (GO:0006586)3.12076870
88epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.09192230
89pseudouridine synthesis (GO:0001522)3.07716750
90positive regulation of lamellipodium assembly (GO:0010592)3.07667193
91defense response to protozoan (GO:0042832)3.04637755
92antigen receptor-mediated signaling pathway (GO:0050851)3.03039620
93mature B cell differentiation (GO:0002335)3.03032937
94lymphocyte homeostasis (GO:0002260)3.01352456
95cytidine metabolic process (GO:0046087)3.01213445
96cytidine catabolic process (GO:0006216)3.01213445
97cytidine deamination (GO:0009972)3.01213445
98water-soluble vitamin biosynthetic process (GO:0042364)2.99858056
99positive thymic T cell selection (GO:0045059)2.98994952
100negative thymic T cell selection (GO:0045060)2.98906582
101regulation of nuclear cell cycle DNA replication (GO:0033262)2.98492044
102tryptophan catabolic process (GO:0006569)2.98442539
103indole-containing compound catabolic process (GO:0042436)2.98442539
104indolalkylamine catabolic process (GO:0046218)2.98442539
105ketone body metabolic process (GO:1902224)2.97484856
106T cell receptor signaling pathway (GO:0050852)2.97289546
107regulation of type I interferon-mediated signaling pathway (GO:0060338)2.96729166
108interferon-gamma production (GO:0032609)2.95640394
109negative regulation of mast cell activation (GO:0033004)2.95605409
110negative regulation of thymocyte apoptotic process (GO:0070244)2.94530249
111RNA catabolic process (GO:0006401)2.92665263
112response to protozoan (GO:0001562)2.91312287
113V(D)J recombination (GO:0033151)2.89572006
114multicellular organism reproduction (GO:0032504)2.87394093
115positive regulation of lamellipodium organization (GO:1902745)2.87296029
116regulation of regulatory T cell differentiation (GO:0045589)2.86200932
117endothelial tube morphogenesis (GO:0061154)2.86192125
118morphogenesis of an endothelium (GO:0003159)2.86192125
119regulation of T cell mediated cytotoxicity (GO:0001914)2.84984750
120purine-containing compound salvage (GO:0043101)2.83894562
121iron-sulfur cluster assembly (GO:0016226)2.81558064
122metallo-sulfur cluster assembly (GO:0031163)2.81558064
123negative regulation of heart rate (GO:0010459)2.80422528
124cytochrome complex assembly (GO:0017004)2.80385382
125positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.80147551
126positive regulation of natural killer cell differentiation (GO:0032825)2.79498013
127ubiquinone biosynthetic process (GO:0006744)2.79138094
128cellular response to interleukin-4 (GO:0071353)2.78634597
129megakaryocyte development (GO:0035855)2.78312641
130protein-cofactor linkage (GO:0018065)2.78155539
131amine catabolic process (GO:0009310)2.77882275
132cellular biogenic amine catabolic process (GO:0042402)2.77882275
133ribosomal large subunit biogenesis (GO:0042273)2.77598083
134angiogenesis involved in wound healing (GO:0060055)2.77308951
135phosphatidylserine acyl-chain remodeling (GO:0036150)2.75814452
136regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.75435102
137T cell selection (GO:0045058)2.75269590
138regulation of rhodopsin mediated signaling pathway (GO:0022400)2.74505443
139positive T cell selection (GO:0043368)2.74289354
140barbed-end actin filament capping (GO:0051016)2.73170516
141fucosylation (GO:0036065)2.71851987
142T cell migration (GO:0072678)2.70886133
143axoneme assembly (GO:0035082)2.70690017
144autophagic vacuole fusion (GO:0000046)2.70186414
145tryptophan metabolic process (GO:0006568)2.69838631
146DNA strand elongation involved in DNA replication (GO:0006271)2.69511898
147positive regulation of granulocyte differentiation (GO:0030854)2.69183918
148thymic T cell selection (GO:0045061)2.68550934
149sequestering of actin monomers (GO:0042989)2.68398579
150telomere maintenance via semi-conservative replication (GO:0032201)2.68374687
151secretory granule organization (GO:0033363)2.67991540
152T cell differentiation (GO:0030217)2.67924585
153regulation of natural killer cell differentiation (GO:0032823)2.67813505
154ribonucleoprotein complex biogenesis (GO:0022613)2.67578538
155nephron tubule morphogenesis (GO:0072078)2.67460155
156nephron epithelium morphogenesis (GO:0072088)2.67460155
157negative regulation of transcription regulatory region DNA binding (GO:2000678)2.66462127
158rhodopsin mediated signaling pathway (GO:0016056)2.65451853
159dopamine transport (GO:0015872)2.64579064
160phosphatidylethanolamine acyl-chain remodeling (GO:0036152)2.64535239
161regulation of cilium movement (GO:0003352)2.64136022
162cellular response to ATP (GO:0071318)2.64064223
163negative regulation of response to food (GO:0032096)2.63246575
164negative regulation of appetite (GO:0032099)2.63246575
165cornea development in camera-type eye (GO:0061303)2.61714702
166DNA methylation involved in gamete generation (GO:0043046)2.60985213
167kynurenine metabolic process (GO:0070189)2.60357148
168ATP synthesis coupled proton transport (GO:0015986)2.57885720
169energy coupled proton transport, down electrochemical gradient (GO:0015985)2.57885720
170positive regulation of prostaglandin secretion (GO:0032308)2.56908436
171retinal cone cell development (GO:0046549)2.55847258
172adenosine metabolic process (GO:0046085)2.55644734
173positive regulation of fatty acid transport (GO:2000193)2.55024486
174S-adenosylmethionine metabolic process (GO:0046500)2.54178224
175pyrimidine ribonucleoside catabolic process (GO:0046133)2.52891864
176glycerophospholipid catabolic process (GO:0046475)2.49620001
177regulation of endothelial cell differentiation (GO:0045601)2.49213230
178positive regulation of protein homodimerization activity (GO:0090073)2.48918650
179regulation of action potential (GO:0098900)2.47722153
180negative regulation of reactive oxygen species metabolic process (GO:2000378)2.47715861
181regulation of defense response to virus by host (GO:0050691)2.46771676
182reflex (GO:0060004)2.43232712
183ubiquinone metabolic process (GO:0006743)2.43194884
184neuronal action potential (GO:0019228)2.42178576
185cellular response to exogenous dsRNA (GO:0071360)2.41886338
186parturition (GO:0007567)2.41518711
187positive regulation of T cell mediated cytotoxicity (GO:0001916)2.41420976
188male meiosis I (GO:0007141)2.39591991
189mannosylation (GO:0097502)2.39559540
190indole-containing compound metabolic process (GO:0042430)2.38410229
191replication fork processing (GO:0031297)2.38136068
192negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)2.36810086
193positive regulation of T-helper 1 type immune response (GO:0002827)2.36287883
194synaptic transmission, cholinergic (GO:0007271)2.35924208
195regulation of glucokinase activity (GO:0033131)2.35295022
196regulation of hexokinase activity (GO:1903299)2.35295022
197regulation of mesoderm development (GO:2000380)2.33755218
198epithelial cilium movement (GO:0003351)2.32792655

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.38890844
2ZNF274_21170338_ChIP-Seq_K562_Hela4.26918312
3IRF8_22096565_ChIP-ChIP_GC-B_Human3.64893519
4MYC_22102868_ChIP-Seq_BL_Human3.37396797
5VDR_22108803_ChIP-Seq_LS180_Human3.36923371
6SCL_19346495_ChIP-Seq_HPC-7_Human3.35025378
7EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.17483497
8RUNX1_20887958_ChIP-Seq_HPC-7_Mouse3.09185469
9IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.07558858
10STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.99866411
11SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.97731555
12FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.90283038
13MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.87387528
14SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.82379063
15VDR_21846776_ChIP-Seq_THP-1_Human2.77618792
16SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.51665047
17NOTCH1_21737748_ChIP-Seq_TLL_Human2.50273975
18TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.49910396
19GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.46063829
20FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.45137823
21EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human2.42752857
22MYC_18555785_ChIP-Seq_MESCs_Mouse2.42646059
23MAF_26560356_Chip-Seq_TH1_Human2.38884723
24ELF1_17652178_ChIP-ChIP_JURKAT_Human2.38279476
25GBX2_23144817_ChIP-Seq_PC3_Human2.32366778
26IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.31551471
27HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.28436998
28MYB_26560356_Chip-Seq_TH2_Human2.23025108
29UTX_26944678_Chip-Seq_JUKART_Human2.19961854
30STAT4_19710469_ChIP-ChIP_TH1__Mouse2.14359388
31FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.07541350
32IGF1R_20145208_ChIP-Seq_DFB_Human2.07132463
33EWS_26573619_Chip-Seq_HEK293_Human2.05381492
34SPI1_23547873_ChIP-Seq_NB4_Human2.03550105
35RUNX_20019798_ChIP-Seq_JUKART_Human2.02079864
36MYB_26560356_Chip-Seq_TH1_Human1.96442287
37FLI1_27457419_Chip-Seq_LIVER_Mouse1.94625115
38TP53_22573176_ChIP-Seq_HFKS_Human1.93551609
39EZH2_22144423_ChIP-Seq_EOC_Human1.93305950
40TCF7_22412390_ChIP-Seq_EML_Mouse1.89901630
41LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.86359884
42SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.84376686
43* VDR_24763502_ChIP-Seq_THP-1_Human1.82736433
44ERG_20887958_ChIP-Seq_HPC-7_Mouse1.81387515
45RUNX1_22412390_ChIP-Seq_EML_Mouse1.81014404
46IRF1_19129219_ChIP-ChIP_H3396_Human1.80953280
47ZFP57_27257070_Chip-Seq_ESCs_Mouse1.78694989
48CIITA_25753668_ChIP-Seq_RAJI_Human1.76761881
49MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.75921169
50E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.75348331
51FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.73937310
52GATA1_22025678_ChIP-Seq_K562_Human1.72214086
53MYB_21317192_ChIP-Seq_ERMYB_Mouse1.70603707
54GATA3_21878914_ChIP-Seq_MCF-7_Human1.69677229
55POU3F2_20337985_ChIP-ChIP_501MEL_Human1.69352021
56MYC_18940864_ChIP-ChIP_HL60_Human1.69257201
57ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.67296283
58CTBP1_25329375_ChIP-Seq_LNCAP_Human1.66306769
59* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.65690431
60* ELK3_25401928_ChIP-Seq_HUVEC_Human1.65285674
61ER_23166858_ChIP-Seq_MCF-7_Human1.65230425
62GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.64555902
63LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.62435348
64IRF8_21731497_ChIP-ChIP_J774_Mouse1.62353406
65BCAT_22108803_ChIP-Seq_LS180_Human1.61537205
66CTBP2_25329375_ChIP-Seq_LNCAP_Human1.61233855
67FOXA1_27270436_Chip-Seq_PROSTATE_Human1.60312366
68FOXA1_25329375_ChIP-Seq_VCAP_Human1.60312366
69XRN2_22483619_ChIP-Seq_HELA_Human1.59357275
70IKZF1_21737484_ChIP-ChIP_HCT116_Human1.58347118
71STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.58188680
72VDR_23849224_ChIP-Seq_CD4+_Human1.57703939
73MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.56749955
74KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.55451785
75HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.54716605
76GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.54678235
77GATA1_22383799_ChIP-Seq_G1ME_Mouse1.54099095
78FOXP3_21729870_ChIP-Seq_TREG_Human1.53515466
79MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.53509250
80HOXB4_20404135_ChIP-ChIP_EML_Mouse1.53014828
81P300_19829295_ChIP-Seq_ESCs_Human1.52137596
82* MAF_26560356_Chip-Seq_TH2_Human1.51630911
83EGR1_19374776_ChIP-ChIP_THP-1_Human1.51300074
84TAF15_26573619_Chip-Seq_HEK293_Human1.50493101
85NANOG_20526341_ChIP-Seq_ESCs_Human1.50095970
86FUS_26573619_Chip-Seq_HEK293_Human1.49430936
87MYC_19079543_ChIP-ChIP_MESCs_Mouse1.48685153
88AR_20517297_ChIP-Seq_VCAP_Human1.48617780
89SOX2_19829295_ChIP-Seq_ESCs_Human1.44891117
90NANOG_19829295_ChIP-Seq_ESCs_Human1.44891117
91E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.44378898
92BRD4_27068464_Chip-Seq_AML-cells_Mouse1.44214668
93NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.43685427
94GABP_17652178_ChIP-ChIP_JURKAT_Human1.43373408
95ETV2_25802403_ChIP-Seq_MESCs_Mouse1.43178347
96TAF2_19829295_ChIP-Seq_ESCs_Human1.42675228
97BP1_19119308_ChIP-ChIP_Hs578T_Human1.42419540
98EGR1_23403033_ChIP-Seq_LIVER_Mouse1.41947463
99EST1_17652178_ChIP-ChIP_JURKAT_Human1.40040293
100* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.38027648
101TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.37637649
102NCOR_22424771_ChIP-Seq_293T_Human1.37241928
103GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.37122847
104HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.36795998
105EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.36766431
106NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.36379633
107MYC_19030024_ChIP-ChIP_MESCs_Mouse1.36175712
108NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.36170832
109BMI1_23680149_ChIP-Seq_NPCS_Mouse1.34982058
110* ERA_21632823_ChIP-Seq_H3396_Human1.34735694
111SRF_21415370_ChIP-Seq_HL-1_Mouse1.33450376
112UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.32855230
113SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.32081337
114KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.31815547
115GATA2_22383799_ChIP-Seq_G1ME_Mouse1.30066719
116HOXB7_26014856_ChIP-Seq_BT474_Human1.28645184
117KDM2B_26808549_Chip-Seq_DND41_Human1.28107341
118PCGF2_27294783_Chip-Seq_ESCs_Mouse1.28001155
119JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.27592464
120GATA3_26560356_Chip-Seq_TH2_Human1.26844939
121ETS1_20019798_ChIP-Seq_JURKAT_Human1.26583106
122E2F4_17652178_ChIP-ChIP_JURKAT_Human1.25858828
123RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.25282022
124SPI1_23127762_ChIP-Seq_K562_Human1.24456085
125FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.23136724
126* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.22856514
127FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.22508987
128PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.21933734
129AR_25329375_ChIP-Seq_VCAP_Human1.19926377
130FOXA1_21572438_ChIP-Seq_LNCaP_Human1.18013071
131P53_21459846_ChIP-Seq_SAOS-2_Human1.16608087
132GATA3_27048872_Chip-Seq_THYMUS_Human1.16572127
133MYC_19829295_ChIP-Seq_ESCs_Human1.16526158
134REST_21632747_ChIP-Seq_MESCs_Mouse1.14172172
135TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.13641256
136PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.13384432
137NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.13254329
138KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.13034628
139IRF8_27001747_Chip-Seq_BMDM_Mouse1.12820170
140FOXM1_23109430_ChIP-Seq_U2OS_Human1.12264904
141EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.12034133
142NELFA_20434984_ChIP-Seq_ESCs_Mouse1.09290131
143GABP_19822575_ChIP-Seq_HepG2_Human1.08913402
144CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.08894301
145OCT4_20526341_ChIP-Seq_ESCs_Human1.08225670
146RNF2_27304074_Chip-Seq_NSC_Mouse1.08216426
147TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.08128976
148GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.07098156
149STAT3_23295773_ChIP-Seq_U87_Human1.06885479
150SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.06526319
151RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.05763438
152EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.04594528
153CBP_20019798_ChIP-Seq_JUKART_Human1.04117484
154IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.04117484
155TCF4_23295773_ChIP-Seq_U87_Human1.02842152
156LXR_22292898_ChIP-Seq_THP-1_Human1.01828436
157SMAD4_21741376_ChIP-Seq_EPCs_Human1.01760648
158E2F1_18555785_ChIP-Seq_MESCs_Mouse1.01642739
159ERG_20517297_ChIP-Seq_VCAP_Human1.01469160
160GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human1.00086548
161* PU.1_20513432_ChIP-Seq_Bcells_Mouse0.99576720
162ZFX_18555785_ChIP-Seq_MESCs_Mouse0.98907545
163PRDM14_20953172_ChIP-Seq_ESCs_Human0.98458575
164POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.98042747
165TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98042747
166FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.97313981
167TCF4_22108803_ChIP-Seq_LS180_Human0.96421270
168TDRD3_21172665_ChIP-Seq_MCF-7_Human0.95708458
169NR3C1_21868756_ChIP-Seq_MCF10A_Human0.95498017
170ELK1_19687146_ChIP-ChIP_HELA_Human0.95171838
171BCL6_27268052_Chip-Seq_Bcells_Human0.94595212
172* FLI1_21867929_ChIP-Seq_TH2_Mouse0.93950745
173RAC3_21632823_ChIP-Seq_H3396_Human0.92620491
174DCP1A_22483619_ChIP-Seq_HELA_Human0.92483951
175CBX2_27304074_Chip-Seq_ESCs_Mouse0.91936901
176* HTT_18923047_ChIP-ChIP_STHdh_Human0.91630287
177TTF2_22483619_ChIP-Seq_HELA_Human0.91584844
178FOXH1_21741376_ChIP-Seq_ESCs_Human0.91391361
179GATA1_19941827_ChIP-Seq_MEL_Mouse0.91218880
180EZH2_27294783_Chip-Seq_NPCs_Mouse0.90910310
181CTCF_21964334_Chip-Seq_Bcells_Human0.90317801
182STAT1_20625510_ChIP-Seq_HELA_Human0.90236909
183CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.88005815
184* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.87842695
185CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.87698442

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002396_abnormal_hematopoietic_system4.47225528
2MP0003763_abnormal_thymus_physiology4.15362407
3MP0000685_abnormal_immune_system3.64842192
4MP0002102_abnormal_ear_morphology3.23195379
5MP0001835_abnormal_antigen_presentation3.11908968
6MP0005671_abnormal_response_to3.10640017
7MP0009785_altered_susceptibility_to2.91059286
8MP0004808_abnormal_hematopoietic_stem2.79595991
9MP0001968_abnormal_touch/_nociception2.74176766
10MP0003195_calcinosis2.69321845
11MP0002398_abnormal_bone_marrow2.68612504
12MP0001800_abnormal_humoral_immune2.66553524
13MP0002166_altered_tumor_susceptibility2.63839035
14MP0009333_abnormal_splenocyte_physiolog2.53596025
15MP0008875_abnormal_xenobiotic_pharmacok2.42354292
16MP0008872_abnormal_physiological_respon2.40279017
17MP0002420_abnormal_adaptive_immunity2.38208092
18* MP0002723_abnormal_immune_serum2.36147281
19MP0005397_hematopoietic_system_phenotyp2.34734119
20MP0001545_abnormal_hematopoietic_system2.34734119
21MP0001819_abnormal_immune_cell2.34065183
22MP0005025_abnormal_response_to2.31240532
23MP0005551_abnormal_eye_electrophysiolog2.28944631
24MP0002452_abnormal_antigen_presenting2.27877344
25* MP0000689_abnormal_spleen_morphology2.26576024
26* MP0002722_abnormal_immune_system2.23816307
27MP0000716_abnormal_immune_system2.19338633
28MP0000703_abnormal_thymus_morphology2.17563051
29* MP0001790_abnormal_immune_system2.16370393
30* MP0005387_immune_system_phenotype2.16370393
31MP0002736_abnormal_nociception_after2.13824976
32MP0005000_abnormal_immune_tolerance2.12049261
33* MP0005464_abnormal_platelet_physiology2.08585293
34MP0005075_abnormal_melanosome_morpholog2.03616652
35MP0010368_abnormal_lymphatic_system2.01241675
36MP0010155_abnormal_intestine_physiology1.99921434
37MP0002429_abnormal_blood_cell1.98697135
38MP0002405_respiratory_system_inflammati1.97764916
39MP0003724_increased_susceptibility_to1.97625134
40MP0008877_abnormal_DNA_methylation1.96849248
41MP0002006_tumorigenesis1.95091608
42MP0005174_abnormal_tail_pigmentation1.92503413
43MP0006072_abnormal_retinal_apoptosis1.87279341
44MP0001879_abnormal_lymphatic_vessel1.80092957
45MP0000465_gastrointestinal_hemorrhage1.79061715
46MP0003136_yellow_coat_color1.76720538
47MP0003436_decreased_susceptibility_to1.76104286
48MP0000490_abnormal_crypts_of1.72471986
49MP0006054_spinal_hemorrhage1.70544064
50* MP0002148_abnormal_hypersensitivity_rea1.69361163
51MP0002876_abnormal_thyroid_physiology1.68732620
52MP0005645_abnormal_hypothalamus_physiol1.67936206
53MP0009278_abnormal_bone_marrow1.67931147
54MP0002638_abnormal_pupillary_reflex1.67712456
55MP0003646_muscle_fatigue1.67212710
56MP0005253_abnormal_eye_physiology1.67050904
57MP0008775_abnormal_heart_ventricle1.66980329
58MP0005646_abnormal_pituitary_gland1.65566557
59MP0003866_abnormal_defecation1.63602893
60MP0002653_abnormal_ependyma_morphology1.62195278
61MP0004885_abnormal_endolymph1.60132769
62MP0002419_abnormal_innate_immunity1.59074929
63MP0001485_abnormal_pinna_reflex1.56964241
64MP0000230_abnormal_systemic_arterial1.56925118
65MP0004133_heterotaxia1.56776825
66MP0002837_dystrophic_cardiac_calcinosis1.55079242
67MP0004142_abnormal_muscle_tone1.54665351
68MP0009745_abnormal_behavioral_response1.52548730
69MP0009379_abnormal_foot_pigmentation1.52416306
70MP0008007_abnormal_cellular_replicative1.51489085
71MP0004043_abnormal_pH_regulation1.49031812
72MP0001873_stomach_inflammation1.46166445
73MP0005410_abnormal_fertilization1.46090559
74MP0001845_abnormal_inflammatory_respons1.45709979
75MP0001501_abnormal_sleep_pattern1.44701253
76MP0001853_heart_inflammation1.43477662
77MP0010386_abnormal_urinary_bladder1.42259077
78MP0002733_abnormal_thermal_nociception1.40741719
79MP0001905_abnormal_dopamine_level1.39328274
80MP0003011_delayed_dark_adaptation1.37720463
81MP0002933_joint_inflammation1.36931265
82MP0006276_abnormal_autonomic_nervous1.36433331
83MP0002095_abnormal_skin_pigmentation1.35690894
84MP0004947_skin_inflammation1.33773905
85MP0002019_abnormal_tumor_incidence1.29179296
86MP0001970_abnormal_pain_threshold1.29145936
87MP0003077_abnormal_cell_cycle1.27753912
88MP0003693_abnormal_embryo_hatching1.27360913
89MP0003878_abnormal_ear_physiology1.26479737
90MP0005377_hearing/vestibular/ear_phenot1.26479737
91MP0002272_abnormal_nervous_system1.26139356
92MP0009046_muscle_twitch1.24101142
93MP0002735_abnormal_chemical_nociception1.23589816
94MP0008469_abnormal_protein_level1.19036757
95MP0000372_irregular_coat_pigmentation1.18240443
96MP0005409_darkened_coat_color1.16291244
97MP0005023_abnormal_wound_healing1.16035028
98MP0005389_reproductive_system_phenotype1.15900240
99MP0003279_aneurysm1.15366861
100MP0010094_abnormal_chromosome_stability1.14175847
101MP0005171_absent_coat_pigmentation1.14026885
102MP0003828_pulmonary_edema1.12883303
103MP0002138_abnormal_hepatobiliary_system1.12431886
104MP0000858_altered_metastatic_potential1.12004628
105MP0002160_abnormal_reproductive_system1.11404171
106MP0010329_abnormal_lipoprotein_level1.10829828
107MP0004742_abnormal_vestibular_system1.09311500
108MP0003300_gastrointestinal_ulcer1.08831953
109MP0000631_abnormal_neuroendocrine_gland1.08237421
110MP0005083_abnormal_biliary_tract1.07229240
111MP0004957_abnormal_blastocyst_morpholog1.07153008
112MP0001919_abnormal_reproductive_system1.05104939
113MP0004215_abnormal_myocardial_fiber1.04679745
114MP0002938_white_spotting1.04482933
115MP0004147_increased_porphyrin_level1.02959606
116MP0000569_abnormal_digit_pigmentation0.98133054
117MP0002132_abnormal_respiratory_system0.94901135
118MP0003943_abnormal_hepatobiliary_system0.94786892
119MP0002572_abnormal_emotion/affect_behav0.92154159
120MP0005379_endocrine/exocrine_gland_phen0.92032029
121MP0003283_abnormal_digestive_organ0.91774268
122MP0002163_abnormal_gland_morphology0.91481657
123MP0003638_abnormal_response/metabolism_0.90997266
124MP0004130_abnormal_muscle_cell0.88941697
125MP0001765_abnormal_ion_homeostasis0.88872947
126MP0001663_abnormal_digestive_system0.87891267
127MP0005448_abnormal_energy_balance0.87867086
128MP0002557_abnormal_social/conspecific_i0.87370458
129MP0002693_abnormal_pancreas_physiology0.87307423
130MP0001486_abnormal_startle_reflex0.86759693
131MP0003718_maternal_effect0.86195687
132MP0005332_abnormal_amino_acid0.85657675
133MP0000427_abnormal_hair_cycle0.84199728
134MP0002277_abnormal_respiratory_mucosa0.83132127
135MP0005195_abnormal_posterior_eye0.82422892
136MP0003806_abnormal_nucleotide_metabolis0.81874229
137MP0002067_abnormal_sensory_capabilities0.81601789
138MP0000477_abnormal_intestine_morphology0.80940368
139MP0001963_abnormal_hearing_physiology0.80432001
140MP0003137_abnormal_impulse_conducting0.80023411
141MP0002064_seizures0.79971645
142MP0002909_abnormal_adrenal_gland0.79743795
143MP0003303_peritoneal_inflammation0.78334741
144MP0004145_abnormal_muscle_electrophysio0.78298780
145MP0000015_abnormal_ear_pigmentation0.77865509
146MP0001756_abnormal_urination0.76523371
147MP0005084_abnormal_gallbladder_morpholo0.76309146
148MP0000313_abnormal_cell_death0.76238014
149MP0000026_abnormal_inner_ear0.75655887
150MP0003191_abnormal_cellular_cholesterol0.74399124
151MP0003567_abnormal_fetal_cardiomyocyte0.73960021
152MP0008873_increased_physiological_sensi0.71938199
153MP0009763_increased_sensitivity_to0.71338943
154MP0006036_abnormal_mitochondrial_physio0.68992129
155MP0009765_abnormal_xenobiotic_induced0.68752183
156MP0000343_altered_response_to0.67683859
157MP0002128_abnormal_blood_circulation0.65378984
158MP0000767_abnormal_smooth_muscle0.65048957
159MP0008057_abnormal_DNA_replication0.64891022
160MP0001533_abnormal_skeleton_physiology0.64642317
161MP0006082_CNS_inflammation0.64636736
162* MP0000249_abnormal_blood_vessel0.60621914
163MP0008058_abnormal_DNA_repair0.60388141
164MP0005220_abnormal_exocrine_pancreas0.59841343
165MP0010352_gastrointestinal_tract_polyps0.59349659
166MP0009764_decreased_sensitivity_to0.58787495
167MP0003186_abnormal_redox_activity0.58392236
168MP0000598_abnormal_liver_morphology0.58390079
169MP0003448_altered_tumor_morphology0.57746014
170MP0002928_abnormal_bile_duct0.57142485
171MP0003656_abnormal_erythrocyte_physiolo0.55399570
172MP0001986_abnormal_taste_sensitivity0.54920591
173MP0002089_abnormal_postnatal_growth/wei0.53484023
174MP0006292_abnormal_olfactory_placode0.53455554
175MP0005167_abnormal_blood-brain_barrier0.52994132
176MP0002136_abnormal_kidney_physiology0.51598972
177MP0003111_abnormal_nucleus_morphology0.50824271
178MP0002075_abnormal_coat/hair_pigmentati0.49998227

Predicted human phenotypes

RankGene SetZ-score
1Elevated erythrocyte sedimentation rate (HP:0003565)6.15815018
2Panhypogammaglobulinemia (HP:0003139)5.46429316
3Thrombocytosis (HP:0001894)5.27112586
4IgM deficiency (HP:0002850)4.88566460
5Chronic otitis media (HP:0000389)4.56525092
6Myositis (HP:0100614)4.43287850
7Congenital stationary night blindness (HP:0007642)4.40836175
8T lymphocytopenia (HP:0005403)4.31353890
9Recurrent bronchitis (HP:0002837)4.07701206
10Pancreatic cysts (HP:0001737)4.04225427
11Abnormality of T cell number (HP:0011839)4.03065051
12Recurrent viral infections (HP:0004429)4.00077174
13Abnormal delayed hypersensitivity skin test (HP:0002963)3.98450844
14Abnormality of T cells (HP:0002843)3.94918071
15Abnormality of the nasal mucosa (HP:0000433)3.86930636
16Reticulocytopenia (HP:0001896)3.86313650
17Molar tooth sign on MRI (HP:0002419)3.85137997
18Abnormality of midbrain morphology (HP:0002418)3.85137997
19Abnormality of B cell number (HP:0010975)3.82402202
20B lymphocytopenia (HP:0010976)3.82402202
21Abnormality of cells of the erythroid lineage (HP:0012130)3.73619572
22Spontaneous hematomas (HP:0007420)3.53080464
23Pancreatic fibrosis (HP:0100732)3.51754028
24Abnormal number of erythroid precursors (HP:0012131)3.50924559
25Attenuation of retinal blood vessels (HP:0007843)3.49588275
26Gastrointestinal inflammation (HP:0004386)3.42671411
27Type II lissencephaly (HP:0007260)3.41139283
28True hermaphroditism (HP:0010459)3.40236614
29Thyroiditis (HP:0100646)3.37156288
30Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.37005475
31Abnormality of alanine metabolism (HP:0010916)3.37005475
32Hyperalaninemia (HP:0003348)3.37005475
33Nasal polyposis (HP:0100582)3.36779531
34Prolonged bleeding time (HP:0003010)3.36089760
35Abnormality of T cell physiology (HP:0011840)3.28784271
36Agammaglobulinemia (HP:0004432)3.27231427
37Cellulitis (HP:0100658)3.21487338
38IgG deficiency (HP:0004315)3.16752094
39Aplastic anemia (HP:0001915)3.14393941
40Inflammation of the large intestine (HP:0002037)3.14074457
41Severe combined immunodeficiency (HP:0004430)3.12772189
42Abnormality of the renal cortex (HP:0011035)3.06691530
43Abolished electroretinogram (ERG) (HP:0000550)3.05046676
44Nephronophthisis (HP:0000090)3.04839876
45Recurrent fungal infections (HP:0002841)3.03323548
46Abnormal drinking behavior (HP:0030082)3.02654526
47Polydipsia (HP:0001959)3.02654526
48Combined immunodeficiency (HP:0005387)3.01913643
49Meningitis (HP:0001287)2.99452652
50Acute lymphatic leukemia (HP:0006721)2.95147347
51Hypoplasia of the thymus (HP:0000778)2.90578882
52Epistaxis (HP:0000421)2.87223654
53Congenital, generalized hypertrichosis (HP:0004540)2.84166030
54Abnormal rod and cone electroretinograms (HP:0008323)2.83565419
55Hypoproteinemia (HP:0003075)2.81275842
56Decreased central vision (HP:0007663)2.81073081
57Interstitial pulmonary disease (HP:0006530)2.76693602
583-Methylglutaconic aciduria (HP:0003535)2.76061491
59Pendular nystagmus (HP:0012043)2.73586793
60Abnormality of the renal medulla (HP:0100957)2.72210260
61Pustule (HP:0200039)2.69141562
62Stomatitis (HP:0010280)2.66860931
63Lymphopenia (HP:0001888)2.65311277
64Pallor (HP:0000980)2.64836444
65Acute myeloid leukemia (HP:0004808)2.59895878
66Colon cancer (HP:0003003)2.58873043
67Colitis (HP:0002583)2.58791310
68Petechiae (HP:0000967)2.58298185
69Microcytic anemia (HP:0001935)2.58055059
70Abnormality of cells of the lymphoid lineage (HP:0012140)2.56271307
71Hematochezia (HP:0002573)2.53351708
72Autoimmune thrombocytopenia (HP:0001973)2.53257678
73Macrocytic anemia (HP:0001972)2.52824353
74Tubular atrophy (HP:0000092)2.52140057
75Concave nail (HP:0001598)2.51084407
76Inability to walk (HP:0002540)2.48022332
77Decreased electroretinogram (ERG) amplitude (HP:0000654)2.47097476
78Basal cell carcinoma (HP:0002671)2.46206092
79Polyuria (HP:0000103)2.41728151
80Recurrent abscess formation (HP:0002722)2.41461015
81Recurrent sinusitis (HP:0011108)2.41458064
82Abnormality of the fingertips (HP:0001211)2.41362360
83Erythema (HP:0010783)2.40909293
84Chronic sinusitis (HP:0011109)2.39542928
85Mitochondrial inheritance (HP:0001427)2.39485479
86Eosinophilia (HP:0001880)2.39471905
87Lymphoma (HP:0002665)2.37917871
88Verrucae (HP:0200043)2.36738393
89Papilloma (HP:0012740)2.36738393
90Abnormal biliary tract physiology (HP:0012439)2.36195127
91Bile duct proliferation (HP:0001408)2.36195127
92Medial flaring of the eyebrow (HP:0010747)2.35352712
93Abnormality of eosinophils (HP:0001879)2.34844930
94Acute necrotizing encephalopathy (HP:0006965)2.34545976
95Purpura (HP:0000979)2.34382184
96Cystic liver disease (HP:0006706)2.33734337
97Abnormal platelet function (HP:0011869)2.33521620
98Impaired platelet aggregation (HP:0003540)2.33521620
99Gastrointestinal stroma tumor (HP:0100723)2.32433021
100Decreased circulating renin level (HP:0003351)2.32215209
101Amaurosis fugax (HP:0100576)2.30834860
102Granulocytopenia (HP:0001913)2.30420043
103Renal cortical cysts (HP:0000803)2.28202367
104Large for gestational age (HP:0001520)2.27567345
105Lipid accumulation in hepatocytes (HP:0006561)2.27267136
106Cerebellar dysplasia (HP:0007033)2.27205171
107Increased CSF lactate (HP:0002490)2.25848899
108Progressive inability to walk (HP:0002505)2.20881171
109Lissencephaly (HP:0001339)2.20751604
110Gingival bleeding (HP:0000225)2.19121004
111Severe muscular hypotonia (HP:0006829)2.18932944
112Increased corneal curvature (HP:0100692)2.18389048
113Keratoconus (HP:0000563)2.18389048
114Chorioretinal atrophy (HP:0000533)2.18366559
115Hyperlipoproteinemia (HP:0010980)2.17415129
116Sclerocornea (HP:0000647)2.16264241
117Poikiloderma (HP:0001029)2.15208112
118Increased IgE level (HP:0003212)2.14396411
119Recurrent bacterial skin infections (HP:0005406)2.12236295
120Bronchitis (HP:0012387)2.11991046
121Chronic diarrhea (HP:0002028)2.11908404
122Recurrent skin infections (HP:0001581)2.11028550
123Abnormal mitochondria in muscle tissue (HP:0008316)2.10312183
124Hypergammaglobulinemia (HP:0010702)2.09381878
125Decreased activity of mitochondrial respiratory chain (HP:0008972)2.09304313
126Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.09304313
127Absent/shortened dynein arms (HP:0200106)2.08872210
128Dynein arm defect of respiratory motile cilia (HP:0012255)2.08872210
129Recurrent cutaneous fungal infections (HP:0011370)2.08024393
130Chronic mucocutaneous candidiasis (HP:0002728)2.08024393
131Bony spicule pigmentary retinopathy (HP:0007737)2.06321357
132Chronic hepatic failure (HP:0100626)2.06047435
133Leukocytosis (HP:0001974)2.05780358
134Mesangial abnormality (HP:0001966)2.05656016
135Acute encephalopathy (HP:0006846)2.05644812
136Clumsiness (HP:0002312)2.05170012
13711 pairs of ribs (HP:0000878)2.03524936
138Methylmalonic acidemia (HP:0002912)2.03346069
139Encephalitis (HP:0002383)2.02927851
140Progressive macrocephaly (HP:0004481)2.02091730
141Optic disc pallor (HP:0000543)2.01640771
142Ketoacidosis (HP:0001993)2.00469658
143Abnormal respiratory motile cilium morphology (HP:0005938)1.97234217
144Abnormal respiratory epithelium morphology (HP:0012253)1.97234217
145Protrusio acetabuli (HP:0003179)1.96337530
146Menorrhagia (HP:0000132)1.95289762
147Methylmalonic aciduria (HP:0012120)1.94527735
148Furrowed tongue (HP:0000221)1.93506031
149Aplasia/Hypoplasia of the spleen (HP:0010451)1.93282599
150Hypoplasia of the pons (HP:0012110)1.93266528
151Ragged-red muscle fibers (HP:0003200)1.92840681
152Absent rod-and cone-mediated responses on ERG (HP:0007688)1.92829111
153Increased hepatocellular lipid droplets (HP:0006565)1.92699344
154Congenital hepatic fibrosis (HP:0002612)1.92064682
155Abnormality of the pons (HP:0007361)1.91860291
156Male pseudohermaphroditism (HP:0000037)1.91835260
157Muscle fiber atrophy (HP:0100295)1.91333324
158Fatigue (HP:0012378)1.90831333
159Joint swelling (HP:0001386)1.90042082
160Abnormal urine output (HP:0012590)1.89017089
161Emphysema (HP:0002097)1.88678938
162Reduced antithrombin III activity (HP:0001976)1.88643666
163Renal Fanconi syndrome (HP:0001994)1.88454897
164Aplasia/Hypoplasia of the patella (HP:0006498)1.85524779
165Vasculitis (HP:0002633)1.84792835
166Congenital sensorineural hearing impairment (HP:0008527)1.83695624
167Patellar aplasia (HP:0006443)1.82832864
168Eczematoid dermatitis (HP:0000976)1.82680042
169Type 2 muscle fiber atrophy (HP:0003554)1.82645895
170Entropion (HP:0000621)1.82413112
171Chest pain (HP:0100749)1.81765097
172Mediastinal lymphadenopathy (HP:0100721)1.81018464
173Ketosis (HP:0001946)1.80900764
174Disproportionate short-trunk short stature (HP:0003521)1.80499533
175Bulbous nose (HP:0000414)1.80003953
176Nonimmune hydrops fetalis (HP:0001790)1.79907572
177Migraine (HP:0002076)1.79861388
178Hyperventilation (HP:0002883)1.79192356
179Pancytopenia (HP:0001876)1.78957150
180Asplenia (HP:0001746)1.78029132
181Hemiparesis (HP:0001269)1.77270314
182Anencephaly (HP:0002323)1.76889696
183Increased serum lactate (HP:0002151)1.73465732
184Absent thumb (HP:0009777)1.71963107
185Pachygyria (HP:0001302)1.71204790
186Tachypnea (HP:0002789)1.70774989
187Exertional dyspnea (HP:0002875)1.70343311
188Abnormality of the renal collecting system (HP:0004742)1.70005293
189Hepatocellular necrosis (HP:0001404)1.69224065
190Aplasia/Hypoplasia of the tibia (HP:0005772)1.69047441
191Hepatic necrosis (HP:0002605)1.67297235
192Hypomagnesemia (HP:0002917)1.66133783
193Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.65697606

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K14.79757273
2FLT34.10850056
3KIT3.92282776
4FRK3.81992073
5NME23.72787248
6TLK13.64415468
7WNK43.42233536
8TAOK33.26458158
9BMPR1B3.03327966
10ZAK2.96714158
11GRK12.95945605
12MAP4K22.77861790
13EEF2K2.67955174
14TXK2.50521202
15* ADRBK22.48564398
16CSF1R2.39061045
17ZAP702.37242820
18KDR2.36777674
19PKN22.35024558
20BTK2.13757024
21TGFBR12.13524611
22TEC2.13244345
23NUAK12.11339085
24DAPK22.09884339
25INSRR2.08456195
26JAK32.05551641
27PINK12.03471757
28TYK22.01084231
29TIE11.93394348
30MAP3K101.92669817
31MAPK151.89517828
32MAP2K31.88369954
33GRK61.82681421
34WNK31.69333082
35NLK1.68125433
36TBK11.68059524
37TGFBR21.66409328
38LRRK21.61915608
39SYK1.55963524
40STK101.46621932
41STK391.46421125
42PTK2B1.45433547
43IKBKE1.43216514
44OXSR11.43067025
45ITK1.42221107
46WEE11.40409238
47MAPK131.39147112
48ERN11.35734618
49LCK1.34291181
50ACVR1B1.34064627
51RPS6KB21.25170316
52TNIK1.19512563
53IRAK41.18149547
54CDK191.17473283
55SCYL21.14426970
56PIM21.12613450
57BLK1.12565868
58FES1.09050898
59CLK11.06264327
60STK161.06081266
61NEK21.04185629
62TRIB31.03901793
63DYRK21.01314599
64* ADRBK10.99111840
65FGFR40.95867943
66DYRK30.94856443
67LYN0.92847521
68VRK20.92596103
69RPS6KA40.92408659
70CAMKK20.92040971
71MAP3K40.91869258
72MAPKAPK30.90986524
73HCK0.89145744
74MAP3K110.83458638
75PAK30.82690227
76MYLK0.82016645
77PNCK0.81569882
78MAP2K60.80155737
79MAPK110.78402509
80PASK0.76841774
81RIPK40.76319125
82RPS6KA50.76131282
83IRAK10.75441466
84IKBKB0.75294365
85GRK50.72540399
86MAP3K130.70779393
87MAP2K20.70615101
88PRKCG0.70235031
89PHKG10.68571112
90PHKG20.68571112
91PRKCE0.68493366
92MAP2K70.67434134
93MST40.66735999
94TRIM280.65690839
95TESK20.64563373
96ILK0.63985228
97PTK60.63497305
98MATK0.62718526
99STK30.62454956
100PKN10.62087856
101PIM10.61368730
102CCNB10.60788386
103BCKDK0.60099137
104MAPK120.57931706
105MUSK0.57805970
106PIK3CG0.57164183
107CSNK1G10.56729951
108CASK0.56354747
109SIK20.55332147
110PRKG20.55290759
111CSNK1G30.55220669
112MAPK40.54605227
113PLK20.53825056
114RIPK10.51155202
115HIPK20.49441818
116BUB10.48641006
117CDK40.48412719
118PRKCI0.48117337
119BMX0.47665345
120JAK10.47293568
121RAF10.47279709
122PAK40.46770309
123STK110.45354476
124CSNK1G20.44994779
125PIK3CA0.44894169
126MAP3K80.43465541
127CHUK0.43042095
128* PRKACA0.42301979
129MAP2K10.42028063
130CSK0.40560632
131PLK30.40125348
132* PRKCA0.39003664
133TAF10.37974469
134NTRK30.37878458
135TAOK10.37804423
136CAMK2A0.37260347
137CDK70.36053163
138RPS6KA60.35945244
139MKNK20.35013579
140FGFR30.33956246
141CSNK1A1L0.33777641
142CDC70.33165440
143BRSK20.32540933
144CSNK1A10.31309579
145WNK10.30705552
146MAP3K10.30505059
147ABL10.30263001
148MARK30.30143078
149MAPKAPK50.27928273
150MAPK30.27403780
151TNK20.27338228
152PRKCH0.26986852
153MAP3K70.26427515
154PAK20.26239298
155PRKCQ0.25932749
156VRK10.25599103
157RPS6KL10.25274725
158RPS6KC10.25274725
159JAK20.24609804
160SIK10.23826959
161PRKD20.23392430
162ATR0.23162522
163CAMK10.22247896

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.86880029
2Primary immunodeficiency_Homo sapiens_hsa053404.82880654
3DNA replication_Homo sapiens_hsa030303.35105250
4Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006033.09700265
5Linoleic acid metabolism_Homo sapiens_hsa005912.97456359
6alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.95021280
7Nitrogen metabolism_Homo sapiens_hsa009102.77703892
8Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.67565047
9Mismatch repair_Homo sapiens_hsa034302.61139255
10Phototransduction_Homo sapiens_hsa047442.56472357
11Base excision repair_Homo sapiens_hsa034102.37177539
12Maturity onset diabetes of the young_Homo sapiens_hsa049502.32090439
13Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.30763484
14Measles_Homo sapiens_hsa051622.20377278
15Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.14324656
16B cell receptor signaling pathway_Homo sapiens_hsa046622.07374558
17Hematopoietic cell lineage_Homo sapiens_hsa046402.03097470
18Oxidative phosphorylation_Homo sapiens_hsa001901.98892564
19RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.97764293
20Selenocompound metabolism_Homo sapiens_hsa004501.96632381
21* Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.93216543
22T cell receptor signaling pathway_Homo sapiens_hsa046601.93047105
23Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.92705751
24Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.89927251
25NF-kappa B signaling pathway_Homo sapiens_hsa040641.85628915
26Arachidonic acid metabolism_Homo sapiens_hsa005901.84326643
27Antigen processing and presentation_Homo sapiens_hsa046121.76590948
28Leishmaniasis_Homo sapiens_hsa051401.73891052
29Ether lipid metabolism_Homo sapiens_hsa005651.72289595
30Herpes simplex infection_Homo sapiens_hsa051681.72282253
31Non-homologous end-joining_Homo sapiens_hsa034501.71316904
32Butanoate metabolism_Homo sapiens_hsa006501.69395439
33Acute myeloid leukemia_Homo sapiens_hsa052211.67180428
34Intestinal immune network for IgA production_Homo sapiens_hsa046721.63518718
35Spliceosome_Homo sapiens_hsa030401.62973381
36Parkinsons disease_Homo sapiens_hsa050121.58094105
37Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.57756416
38Jak-STAT signaling pathway_Homo sapiens_hsa046301.53537495
39Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.52766827
40Pyrimidine metabolism_Homo sapiens_hsa002401.51536330
41Asthma_Homo sapiens_hsa053101.47067924
42Sulfur relay system_Homo sapiens_hsa041221.43361927
43Olfactory transduction_Homo sapiens_hsa047401.39828836
44Osteoclast differentiation_Homo sapiens_hsa043801.34227570
45Leukocyte transendothelial migration_Homo sapiens_hsa046701.33322115
46Nucleotide excision repair_Homo sapiens_hsa034201.32105712
47Shigellosis_Homo sapiens_hsa051311.30254564
48Tryptophan metabolism_Homo sapiens_hsa003801.29297626
49Morphine addiction_Homo sapiens_hsa050321.23605517
50Homologous recombination_Homo sapiens_hsa034401.22304803
51Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.21097048
52* Platelet activation_Homo sapiens_hsa046111.20043139
53Nicotine addiction_Homo sapiens_hsa050331.16809901
54Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.15705263
55Transcriptional misregulation in cancer_Homo sapiens_hsa052021.15539711
56Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.11726604
57Autoimmune thyroid disease_Homo sapiens_hsa053201.11689820
58Regulation of autophagy_Homo sapiens_hsa041401.11182338
59Folate biosynthesis_Homo sapiens_hsa007901.10251876
60Thyroid cancer_Homo sapiens_hsa052161.09134930
61Type I diabetes mellitus_Homo sapiens_hsa049401.08572331
62Sulfur metabolism_Homo sapiens_hsa009201.07162841
63Steroid hormone biosynthesis_Homo sapiens_hsa001401.06993758
64Peroxisome_Homo sapiens_hsa041461.06727339
65RNA polymerase_Homo sapiens_hsa030201.06121034
66Allograft rejection_Homo sapiens_hsa053301.05772445
67Taste transduction_Homo sapiens_hsa047421.05071274
68Cell cycle_Homo sapiens_hsa041101.04413035
69Toll-like receptor signaling pathway_Homo sapiens_hsa046201.04200483
70Chemical carcinogenesis_Homo sapiens_hsa052041.03975131
71Serotonergic synapse_Homo sapiens_hsa047261.03970078
72Caffeine metabolism_Homo sapiens_hsa002321.00472885
73p53 signaling pathway_Homo sapiens_hsa041150.99936144
74Hepatitis B_Homo sapiens_hsa051610.99586468
75Toxoplasmosis_Homo sapiens_hsa051450.99490689
76Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.98552962
77SNARE interactions in vesicular transport_Homo sapiens_hsa041300.97935170
78Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.97903740
79Influenza A_Homo sapiens_hsa051640.97580948
80Graft-versus-host disease_Homo sapiens_hsa053320.94592695
81Proteasome_Homo sapiens_hsa030500.93809879
82Fat digestion and absorption_Homo sapiens_hsa049750.93772385
83Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.93709556
84Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.93535299
85ABC transporters_Homo sapiens_hsa020100.93030242
86Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.92042246
87Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.90927930
88Collecting duct acid secretion_Homo sapiens_hsa049660.90743686
89Notch signaling pathway_Homo sapiens_hsa043300.89868681
90Ovarian steroidogenesis_Homo sapiens_hsa049130.89708896
91Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.89216713
92Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.88127197
93HTLV-I infection_Homo sapiens_hsa051660.87768563
94Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.86788460
95Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.86634560
96Alzheimers disease_Homo sapiens_hsa050100.86521092
97Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.86253989
98Legionellosis_Homo sapiens_hsa051340.85624879
99AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.85022288
100Viral myocarditis_Homo sapiens_hsa054160.84509672
101Primary bile acid biosynthesis_Homo sapiens_hsa001200.84145175
102Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.84044103
103Malaria_Homo sapiens_hsa051440.83700241
104Pentose phosphate pathway_Homo sapiens_hsa000300.82391838
105Circadian entrainment_Homo sapiens_hsa047130.82033152
106Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.80050073
107Protein export_Homo sapiens_hsa030600.78600297
108Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.77348203
109Huntingtons disease_Homo sapiens_hsa050160.76460034
110Drug metabolism - other enzymes_Homo sapiens_hsa009830.76420326
111Epstein-Barr virus infection_Homo sapiens_hsa051690.75861008
112Glycerolipid metabolism_Homo sapiens_hsa005610.75825325
113Retinol metabolism_Homo sapiens_hsa008300.75325641
114NOD-like receptor signaling pathway_Homo sapiens_hsa046210.74104220
115Chronic myeloid leukemia_Homo sapiens_hsa052200.73487534
116Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.70951314
117Cardiac muscle contraction_Homo sapiens_hsa042600.70651232
118N-Glycan biosynthesis_Homo sapiens_hsa005100.70035461
119Small cell lung cancer_Homo sapiens_hsa052220.69630956
120Purine metabolism_Homo sapiens_hsa002300.67985385
121Pertussis_Homo sapiens_hsa051330.67742286
122Apoptosis_Homo sapiens_hsa042100.66352029
123Vascular smooth muscle contraction_Homo sapiens_hsa042700.66183534
124RNA degradation_Homo sapiens_hsa030180.65976269
125GABAergic synapse_Homo sapiens_hsa047270.65637338
126Rheumatoid arthritis_Homo sapiens_hsa053230.64375004
127African trypanosomiasis_Homo sapiens_hsa051430.63699295
128Viral carcinogenesis_Homo sapiens_hsa052030.63631414
129Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.63457426
130Colorectal cancer_Homo sapiens_hsa052100.63203555
131Cyanoamino acid metabolism_Homo sapiens_hsa004600.62449252
132Chemokine signaling pathway_Homo sapiens_hsa040620.60809927
133Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.59587487
134Hepatitis C_Homo sapiens_hsa051600.58028744
135Pancreatic cancer_Homo sapiens_hsa052120.57267305
136Insulin secretion_Homo sapiens_hsa049110.57153819
137VEGF signaling pathway_Homo sapiens_hsa043700.56900850
138RNA transport_Homo sapiens_hsa030130.56537655
139Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.53105604
140Salmonella infection_Homo sapiens_hsa051320.52604860
141Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.51652893
142Metabolic pathways_Homo sapiens_hsa011000.51519378
143TNF signaling pathway_Homo sapiens_hsa046680.50852046
144Other glycan degradation_Homo sapiens_hsa005110.50169878
145Salivary secretion_Homo sapiens_hsa049700.50140846
146* Calcium signaling pathway_Homo sapiens_hsa040200.49759342
147Glycerophospholipid metabolism_Homo sapiens_hsa005640.45691597
148Glutamatergic synapse_Homo sapiens_hsa047240.45485158
149Non-small cell lung cancer_Homo sapiens_hsa052230.43185968
150Pentose and glucuronate interconversions_Homo sapiens_hsa000400.42484017
151Pathways in cancer_Homo sapiens_hsa052000.41062693
152Vitamin digestion and absorption_Homo sapiens_hsa049770.39870885
153Histidine metabolism_Homo sapiens_hsa003400.38423849
154One carbon pool by folate_Homo sapiens_hsa006700.38083050
155Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.38013630
156Neurotrophin signaling pathway_Homo sapiens_hsa047220.36360339
157Tuberculosis_Homo sapiens_hsa051520.35154393
158Fanconi anemia pathway_Homo sapiens_hsa034600.32545599
159Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.31792683
160beta-Alanine metabolism_Homo sapiens_hsa004100.30192725
161Systemic lupus erythematosus_Homo sapiens_hsa053220.29778108
162Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.29553498
163Basal transcription factors_Homo sapiens_hsa030220.26882352
164Propanoate metabolism_Homo sapiens_hsa006400.25266476
165Prolactin signaling pathway_Homo sapiens_hsa049170.25111511
166Central carbon metabolism in cancer_Homo sapiens_hsa052300.25048926
167Pancreatic secretion_Homo sapiens_hsa049720.24665680
168Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.23004242
169Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.22465327
170Focal adhesion_Homo sapiens_hsa045100.21677625
171PI3K-Akt signaling pathway_Homo sapiens_hsa041510.17373339

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