TBX5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This gene is closely linked to related family member T-box 3 (ulnar mammary syndrome) on human chromosome 12. The encoded protein may play a role in heart development and specification of limb identity. Mutations in this gene have been associated with Holt-Oram syndrome, a developmental disorder affecting the heart and upper limbs. Several transcript variants encoding different isoforms have been described for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cardiac myofibril assembly (GO:0055003)7.33556411
2sarcomere organization (GO:0045214)6.84227978
3cardiac right ventricle morphogenesis (GO:0003215)6.47039260
4myofibril assembly (GO:0030239)6.33242436
5* atrial septum morphogenesis (GO:0060413)6.28395717
6cardiac muscle hypertrophy (GO:0003300)6.23127705
7actin-myosin filament sliding (GO:0033275)6.19568706
8muscle filament sliding (GO:0030049)6.19568706
9* regulation of cardioblast differentiation (GO:0051890)5.92572290
10regulation of relaxation of muscle (GO:1901077)5.85806802
11striated muscle hypertrophy (GO:0014897)5.82364230
12cardiac muscle tissue morphogenesis (GO:0055008)5.76172908
13actin-mediated cell contraction (GO:0070252)5.59191923
14* cardiac chamber formation (GO:0003207)5.52615490
15cardiac muscle contraction (GO:0060048)5.41605545
16muscle hypertrophy (GO:0014896)5.34255707
17muscle tissue morphogenesis (GO:0060415)5.14029875
18ventricular cardiac muscle tissue morphogenesis (GO:0055010)5.03933517
19outflow tract septum morphogenesis (GO:0003148)5.02345022
20regulation of sarcomere organization (GO:0060297)4.98064089
21regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO4.93095534
22* positive regulation of cardiac muscle cell proliferation (GO:0060045)4.85217300
23venous blood vessel morphogenesis (GO:0048845)4.84576514
24* positive regulation of cardiac muscle tissue growth (GO:0055023)4.73623946
25heart valve formation (GO:0003188)4.72493343
26regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)4.66798399
27endocardial cushion morphogenesis (GO:0003203)4.65606994
28adult heart development (GO:0007512)4.58104351
29bundle of His cell to Purkinje myocyte communication (GO:0086069)4.56712002
30basement membrane organization (GO:0071711)4.56427465
31actomyosin structure organization (GO:0031032)4.54030500
32regulation of actin filament-based movement (GO:1903115)4.54023661
33muscle hypertrophy in response to stress (GO:0003299)4.48121510
34cardiac muscle adaptation (GO:0014887)4.48121510
35cardiac muscle hypertrophy in response to stress (GO:0014898)4.48121510
36* positive regulation of cardiac muscle tissue development (GO:0055025)4.46941649
37ventricular cardiac muscle cell development (GO:0055015)4.45146197
38endoderm formation (GO:0001706)4.40043809
39negative regulation of cardiac muscle cell apoptotic process (GO:0010667)4.38166070
40regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)4.35365335
41cardiac muscle cell development (GO:0055013)4.33267863
42relaxation of smooth muscle (GO:0044557)4.29538020
43actin filament-based movement (GO:0030048)4.29223462
44positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)4.28451245
45* cell migration involved in heart development (GO:0060973)4.24917218
46* positive regulation of heart growth (GO:0060421)4.20525032
47* atrioventricular valve morphogenesis (GO:0003181)4.15598214
48mesenchyme morphogenesis (GO:0072132)4.11248134
49regulation of skeletal muscle contraction (GO:0014819)4.09147178
50cardiac cell development (GO:0055006)4.08133706
51* cardiac septum development (GO:0003279)4.06526948
52protein heterotrimerization (GO:0070208)4.06334254
53negative regulation of potassium ion transmembrane transporter activity (GO:1901017)4.02768186
54collagen fibril organization (GO:0030199)4.01818517
55regulation of the force of heart contraction (GO:0002026)4.00502986
56striated muscle contraction (GO:0006941)3.92864282
57regulation of striated muscle contraction (GO:0006942)3.88487194
58sarcoplasmic reticulum calcium ion transport (GO:0070296)3.84209073
59negative regulation of potassium ion transmembrane transport (GO:1901380)3.79078393
60regulation of cell communication by electrical coupling (GO:0010649)3.78231358
61ventricular cardiac muscle cell action potential (GO:0086005)3.73160381
62* heart valve morphogenesis (GO:0003179)3.71421701
63negative regulation of striated muscle cell apoptotic process (GO:0010664)3.69782845
64regulation of cardiac muscle cell contraction (GO:0086004)3.61779209
65positive regulation of cardiac muscle cell differentiation (GO:2000727)3.61732062
66* regulation of cardiac muscle cell proliferation (GO:0060043)3.60850613
67bone trabecula formation (GO:0060346)3.59952965
68heart process (GO:0003015)3.59947857
69heart contraction (GO:0060047)3.59947857
70regulation of cardiac muscle contraction (GO:0055117)3.57088663
71extracellular matrix assembly (GO:0085029)3.53773382
72desmosome organization (GO:0002934)3.53264982
73morphogenesis of an epithelial sheet (GO:0002011)3.47609855
74trabecula formation (GO:0060343)3.44354246
75fibroblast migration (GO:0010761)3.43562619
76* regulation of cardiac muscle tissue growth (GO:0055021)3.42778926
77neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)3.40565315
78cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.39058276
79regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)3.37335406
80* regulation of cardiac muscle tissue development (GO:0055024)3.36309432
81negative regulation of protein localization to cell surface (GO:2000009)3.35276603
82sequestering of extracellular ligand from receptor (GO:0035581)3.32295319
83* positive regulation of muscle tissue development (GO:1901863)3.21780400
84regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.21426327
85response to stimulus involved in regulation of muscle adaptation (GO:0014874)3.21273456
86cell communication involved in cardiac conduction (GO:0086065)3.17830226
87cGMP-mediated signaling (GO:0019934)3.17304961
88* positive regulation of striated muscle tissue development (GO:0045844)3.16911590
89* positive regulation of muscle organ development (GO:0048636)3.16911590
90regulation of cardiac muscle cell differentiation (GO:2000725)3.15367049
91* cardiac muscle tissue development (GO:0048738)3.13786260
92cardiac muscle cell action potential (GO:0086001)3.12812744
93positive regulation of heart rate (GO:0010460)3.11910150
94* regulation of heart growth (GO:0060420)3.10727223
95regulation of muscle contraction (GO:0006937)3.10691720
96negative regulation of hormone biosynthetic process (GO:0032353)3.09566405
97regulation of heart contraction (GO:0008016)3.06470185
98heart trabecula formation (GO:0060347)3.05180303
99regulation of ATP catabolic process (GO:1903289)3.04370987
100regulation of ATPase activity (GO:0043462)3.04370987
101regulation of tight junction assembly (GO:2000810)3.02396078
102negative regulation of cardiac muscle hypertrophy (GO:0010614)3.02352106
103positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.99452085
104cell communication by electrical coupling (GO:0010644)2.99154345
105kidney mesenchyme development (GO:0072074)2.97084068
106skin morphogenesis (GO:0043589)2.94783746
107* ventricular septum development (GO:0003281)2.94596677
108* endocardial cushion development (GO:0003197)2.93712284
109positive regulation of heart contraction (GO:0045823)2.91935162
110relaxation of muscle (GO:0090075)2.91875379
111* positive regulation of organ growth (GO:0046622)2.91206472
112regulation of heart rate (GO:0002027)2.91060166
113regulation of cardiac muscle cell apoptotic process (GO:0010665)2.89559829
114striated muscle adaptation (GO:0014888)2.89411528
115relaxation of cardiac muscle (GO:0055119)2.87803971
116regulation of muscle system process (GO:0090257)2.87604141
117metanephric mesenchyme development (GO:0072075)2.85966917
118regulation of membrane repolarization (GO:0060306)2.85802859
119response to redox state (GO:0051775)2.84801631
120endodermal cell differentiation (GO:0035987)2.82927793
121cardiac conduction (GO:0061337)2.82847535
122cardiac muscle cell action potential involved in contraction (GO:0086002)2.81799000
123regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.80255384
124cellular response to epinephrine stimulus (GO:0071872)2.79202387
125endothelial cell morphogenesis (GO:0001886)2.77681550
126paraxial mesoderm development (GO:0048339)2.74707004
127striated muscle cell development (GO:0055002)2.72137822
128negative regulation of hormone metabolic process (GO:0032351)2.68778935

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* EP300_21415370_ChIP-Seq_HL-1_Mouse3.82880975
2TRIM28_21343339_ChIP-Seq_HEK293_Human3.08612578
3GBX2_23144817_ChIP-Seq_PC3_Human3.07299029
4EZH2_22144423_ChIP-Seq_EOC_Human2.93478692
5RARG_19884340_ChIP-ChIP_MEFs_Mouse2.86232532
6CDX2_19796622_ChIP-Seq_MESCs_Mouse2.84942436
7BP1_19119308_ChIP-ChIP_Hs578T_Human2.77690601
8TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.41154067
9HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.24308038
10* EED_16625203_ChIP-ChIP_MESCs_Mouse2.21423511
11SMAD_19615063_ChIP-ChIP_OVARY_Human2.21312264
12CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.20848266
13* EZH2_27304074_Chip-Seq_ESCs_Mouse2.16059200
14SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.09948898
15TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.07706373
16ESR1_20079471_ChIP-ChIP_T-47D_Human2.07044104
17JARID2_20064375_ChIP-Seq_MESCs_Mouse2.06483467
18* SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.97988369
19CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.96548987
20BRD4_25478319_ChIP-Seq_HGPS_Human1.95189632
21PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.94059689
22* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.92716348
23* SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.90440248
24* PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.90142660
25* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.82232981
26GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.80235775
27ZFP57_27257070_Chip-Seq_ESCs_Mouse1.79554329
28MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.77609624
29RNF2_18974828_ChIP-Seq_MESCs_Mouse1.77495634
30EZH2_18974828_ChIP-Seq_MESCs_Mouse1.77495634
31PIAS1_25552417_ChIP-Seq_VCAP_Human1.75099050
32EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.74466584
33* CBX2_27304074_Chip-Seq_ESCs_Mouse1.71572457
34FUS_26573619_Chip-Seq_HEK293_Human1.70009218
35ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.67636663
36RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.65957902
37BMI1_23680149_ChIP-Seq_NPCS_Mouse1.65839098
38* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.65140958
39TP53_16413492_ChIP-PET_HCT116_Human1.64469374
40POU3F2_20337985_ChIP-ChIP_501MEL_Human1.64040514
41TP53_18474530_ChIP-ChIP_U2OS_Human1.62554206
42* SMAD4_21799915_ChIP-Seq_A2780_Human1.61149863
43GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.57046100
44* RNF2_27304074_Chip-Seq_ESCs_Mouse1.55763681
45TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.52774675
46TAF15_26573619_Chip-Seq_HEK293_Human1.52353615
47P300_19829295_ChIP-Seq_ESCs_Human1.51792601
48TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.46676775
49TBX20_22328084_ChIP-Seq_HEART_Mouse1.45001224
50TBX20_22080862_ChIP-Seq_HEART_Mouse1.45001224
51* JARID2_20075857_ChIP-Seq_MESCs_Mouse1.44423622
52* EZH2_27294783_Chip-Seq_ESCs_Mouse1.43870653
53RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.43803272
54* ISL1_27105846_Chip-Seq_CPCs_Mouse1.42171099
55ZNF217_24962896_ChIP-Seq_MCF-7_Human1.41404010
56AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.39304135
57NFIB_24661679_ChIP-Seq_LUNG_Mouse1.38059669
58BCAT_22108803_ChIP-Seq_LS180_Human1.36191243
59* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.34892832
60SMAD3_21741376_ChIP-Seq_EPCs_Human1.34641633
61PCGF2_27294783_Chip-Seq_NPCs_Mouse1.31531713
62STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.31207596
63TOP2B_26459242_ChIP-Seq_MCF-7_Human1.30915864
64PCGF2_27294783_Chip-Seq_ESCs_Mouse1.29937638
65AHR_22903824_ChIP-Seq_MCF-7_Human1.29852008
66PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.29619952
67SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.27886241
68ARNT_22903824_ChIP-Seq_MCF-7_Human1.27194157
69SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.27089357
70CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.26603880
71SOX9_24532713_ChIP-Seq_HFSC_Mouse1.26354023
72SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.25917655
73CTBP2_25329375_ChIP-Seq_LNCAP_Human1.24813119
74CJUN_26792858_Chip-Seq_BT549_Human1.24716101
75E2F1_18555785_Chip-Seq_ESCs_Mouse1.23405379
76TCF4_18268006_ChIP-ChIP_LS174T_Human1.21775475
77PPAR_26484153_Chip-Seq_NCI-H1993_Human1.21710245
78HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.21644695
79WT1_25993318_ChIP-Seq_PODOCYTE_Human1.21474132
80TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.21192366
81CLOCK_20551151_ChIP-Seq_293T_Human1.20992285
82* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.20794939
83SUZ12_27294783_Chip-Seq_NPCs_Mouse1.20134701
84STAT3_23295773_ChIP-Seq_U87_Human1.19529894
85CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.19451432
86PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.18782022
87* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.18573442
88GATA2_21666600_ChIP-Seq_HMVEC_Human1.17926745
89* TP53_20018659_ChIP-ChIP_R1E_Mouse1.17671438
90NRF2_20460467_ChIP-Seq_MEFs_Mouse1.15685693
91NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.15685693
92NR3C1_23031785_ChIP-Seq_PC12_Mouse1.15426508
93NANOG_18555785_Chip-Seq_ESCs_Mouse1.12955455
94NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.12396597
95* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.12175360
96* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.11556429
97P53_22387025_ChIP-Seq_ESCs_Mouse1.10077499
98SALL4_18804426_ChIP-ChIP_XEN_Mouse1.09764410
99EZH2_27294783_Chip-Seq_NPCs_Mouse1.09642595
100MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.08343369
101TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.08108296
102NR3C1_21868756_ChIP-Seq_MCF10A_Human1.07777002
103NFE2_27457419_Chip-Seq_LIVER_Mouse1.07754525
104* TCF4_23295773_ChIP-Seq_U87_Human1.06293283
105GATA4_21415370_ChIP-Seq_HL-1_Mouse1.06184907
106BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.06184619
107SUZ12_18555785_Chip-Seq_ESCs_Mouse1.06037243
108FLI1_27457419_Chip-Seq_LIVER_Mouse1.06035322
109AR_21572438_ChIP-Seq_LNCaP_Human1.05922075
110WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.05920349
111TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.05291518
112* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.05290155
113ER_23166858_ChIP-Seq_MCF-7_Human1.05065112
114SMAD3_21741376_ChIP-Seq_HESCs_Human1.04752277
115WT1_19549856_ChIP-ChIP_CCG9911_Human1.04151655
116FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.03984806
117* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.03865788
118SOX2_21211035_ChIP-Seq_LN229_Gbm1.03818301
119VDR_24787735_ChIP-Seq_THP-1_Human1.03753269
120CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02549360
121STAT3_18555785_Chip-Seq_ESCs_Mouse1.02173732
122VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.01836591
123SA1_22415368_ChIP-Seq_MEFs_Mouse1.01547517
124SMC3_22415368_ChIP-Seq_MEFs_Mouse1.00721476
125TP53_23651856_ChIP-Seq_MEFs_Mouse0.98011803
126BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.94205279
127* RING1B_27294783_Chip-Seq_ESCs_Mouse0.93591930
128PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.93265002
129CTNNB1_20460455_ChIP-Seq_HCT116_Human0.93211855
130JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.92887552
131FOXM1_26456572_ChIP-Seq_MCF-7_Human0.90484671
132NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.89004921
133ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.88302966
134SMAD4_21741376_ChIP-Seq_HESCs_Human0.87126159
135SMC1_22415368_ChIP-Seq_MEFs_Mouse0.86064770
136CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.82928279
137YAP1_20516196_ChIP-Seq_MESCs_Mouse0.82395757

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen5.24566753
2MP0004084_abnormal_cardiac_muscle4.90321924
3MP0004215_abnormal_myocardial_fiber3.96638503
4MP0005275_abnormal_skin_tensile3.75699517
5MP0002837_dystrophic_cardiac_calcinosis3.68091649
6MP0000751_myopathy3.67885928
7MP0005330_cardiomyopathy3.64384073
8MP0003828_pulmonary_edema3.48735119
9MP0000749_muscle_degeneration3.40540330
10MP0002972_abnormal_cardiac_muscle3.38936407
11MP0008775_abnormal_heart_ventricle3.37565641
12MP0004510_myositis3.32347311
13MP0004036_abnormal_muscle_relaxation3.30596174
14MP0003567_abnormal_fetal_cardiomyocyte3.14897607
15MP0001958_emphysema3.09377601
16MP0002127_abnormal_cardiovascular_syste2.76220587
17* MP0003137_abnormal_impulse_conducting2.68870651
18MP0003941_abnormal_skin_development2.67039431
19MP0005620_abnormal_muscle_contractility2.62356944
20MP0006138_congestive_heart_failure2.61673859
21MP0003705_abnormal_hypodermis_morpholog2.46671831
22MP0010630_abnormal_cardiac_muscle2.40364869
23* MP0001544_abnormal_cardiovascular_syste2.39782486
24* MP0005385_cardiovascular_system_phenoty2.39782486
25MP0004484_altered_response_of2.30880582
26* MP0004085_abnormal_heartbeat2.28006670
27MP0001542_abnormal_bone_strength2.22058493
28MP0003950_abnormal_plasma_membrane2.17490358
29MP0003646_muscle_fatigue2.16994407
30MP0004087_abnormal_muscle_fiber2.14103548
31MP0009384_cardiac_valve_regurgitation2.08109686
32MP0002106_abnormal_muscle_physiology2.01515632
33MP0003283_abnormal_digestive_organ1.99455414
34MP0004272_abnormal_basement_membrane1.95484594
35MP0003385_abnormal_body_wall1.91646917
36MP0004145_abnormal_muscle_electrophysio1.90113539
37MP0005623_abnormal_meninges_morphology1.83381055
38MP0006054_spinal_hemorrhage1.83119839
39MP0002295_abnormal_pulmonary_circulatio1.83021458
40MP0003122_maternal_imprinting1.72651850
41* MP0005369_muscle_phenotype1.66359328
42MP0000767_abnormal_smooth_muscle1.64959206
43MP0000566_synostosis1.62067114
44MP0010368_abnormal_lymphatic_system1.54954241
45MP0005248_abnormal_Harderian_gland1.47159729
46MP0003221_abnormal_cardiomyocyte_apopto1.44464990
47MP0002102_abnormal_ear_morphology1.43839519
48MP0005023_abnormal_wound_healing1.39135486
49MP0002269_muscular_atrophy1.35916670
50MP0000750_abnormal_muscle_regeneration1.35525089
51MP0001348_abnormal_lacrimal_gland1.33197964
52MP0003279_aneurysm1.26036960
53MP0010030_abnormal_orbit_morphology1.22027966
54MP0009780_abnormal_chondrocyte_physiolo1.20943055
55MP0004233_abnormal_muscle_weight1.18508046
56* MP0009250_abnormal_appendicular_skeleto1.17233383
57MP0005367_renal/urinary_system_phenotyp1.16492515
58MP0000516_abnormal_urinary_system1.16492515
59MP0005451_abnormal_body_composition1.14177854
60* MP0000266_abnormal_heart_morphology1.13101519
61MP0000759_abnormal_skeletal_muscle1.08673715
62MP0000534_abnormal_ureter_morphology1.08017022
63MP0003136_yellow_coat_color1.07696576
64MP0002128_abnormal_blood_circulation1.05581813
65MP0003566_abnormal_cell_adhesion1.05245694
66MP0005409_darkened_coat_color1.02709084
67MP0000013_abnormal_adipose_tissue1.01374615
68MP0008004_abnormal_stomach_pH0.99232117
69MP0002896_abnormal_bone_mineralization0.98844592
70MP0003942_abnormal_urinary_system0.97504872
71MP0002234_abnormal_pharynx_morphology0.96935322
72MP0009697_abnormal_copulation0.96293065
73MP0004130_abnormal_muscle_cell0.95758370
74MP0001879_abnormal_lymphatic_vessel0.94183348
75MP0005388_respiratory_system_phenotype0.94123734
76MP0002133_abnormal_respiratory_system0.94123734
77MP0000747_muscle_weakness0.91393132
78MP0000462_abnormal_digestive_system0.90097590
79MP0000383_abnormal_hair_follicle0.89646280
80MP0003935_abnormal_craniofacial_develop0.88619221
81* MP0003937_abnormal_limbs/digits/tail_de0.88479167
82* MP0002925_abnormal_cardiovascular_devel0.86006767
83MP0002249_abnormal_larynx_morphology0.85424481
84MP0001188_hyperpigmentation0.83794761
85MP0003121_genomic_imprinting0.83092801
86MP0005165_increased_susceptibility_to0.81330052
87MP0003115_abnormal_respiratory_system0.81028695
88MP0001243_abnormal_dermal_layer0.80510893
89MP0005171_absent_coat_pigmentation0.79878006
90* MP0005390_skeleton_phenotype0.79204695
91MP0005595_abnormal_vascular_smooth0.77310888
92MP0000230_abnormal_systemic_arterial0.77164200
93MP0000343_altered_response_to0.77130024
94MP0004134_abnormal_chest_morphology0.76719263
95MP0000049_abnormal_middle_ear0.75033702
96MP0005670_abnormal_white_adipose0.74381162
97* MP0005503_abnormal_tendon_morphology0.73628240
98MP0002060_abnormal_skin_morphology0.71836840
99MP0002089_abnormal_postnatal_growth/wei0.71683130
100MP0001175_abnormal_lung_morphology0.71118069
101MP0006292_abnormal_olfactory_placode0.70421088
102MP0000762_abnormal_tongue_morphology0.69590672
103MP0001661_extended_life_span0.68019439
104MP0005187_abnormal_penis_morphology0.65277244
105MP0002254_reproductive_system_inflammat0.64504868
106* MP0005508_abnormal_skeleton_morphology0.63146105
107MP0001614_abnormal_blood_vessel0.63103083
108MP0004782_abnormal_surfactant_physiolog0.62981353
109MP0000428_abnormal_craniofacial_morphol0.62833969
110* MP0002108_abnormal_muscle_morphology0.62170001
111MP0000003_abnormal_adipose_tissue0.61535240
112* MP0001784_abnormal_fluid_regulation0.61439349
113MP0009053_abnormal_anal_canal0.60876735
114* MP0002109_abnormal_limb_morphology0.60086196
115MP0005164_abnormal_response_to0.59745930
116MP0005257_abnormal_intraocular_pressure0.59274244
117MP0000733_abnormal_muscle_development0.58020673
118MP0001299_abnormal_eye_distance/0.57633109
119MP0000163_abnormal_cartilage_morphology0.56818918
120MP0002938_white_spotting0.54470745
121MP0001177_atelectasis0.54214890
122MP0003091_abnormal_cell_migration0.53898194
123MP0002233_abnormal_nose_morphology0.51875822
124MP0003755_abnormal_palate_morphology0.49456991
125MP0002282_abnormal_trachea_morphology0.47303911
126* MP0002115_abnormal_skeleton_extremities0.44925925
127MP0000432_abnormal_head_morphology0.44296453
128MP0002933_joint_inflammation0.43479308

Predicted human phenotypes

RankGene SetZ-score
1Sudden death (HP:0001699)8.48725097
2Right ventricular cardiomyopathy (HP:0011663)6.67005952
3Atrial fibrillation (HP:0005110)6.60883203
4Ventricular tachycardia (HP:0004756)6.35903526
5Primary atrial arrhythmia (HP:0001692)6.11161160
6Supraventricular tachycardia (HP:0004755)5.83777355
7Supraventricular arrhythmia (HP:0005115)5.69962832
8Calf muscle hypertrophy (HP:0008981)5.65737503
9Lipoatrophy (HP:0100578)5.28541019
10Protrusio acetabuli (HP:0003179)5.20086018
11Abnormality of the calf musculature (HP:0001430)5.16259125
12Muscle hypertrophy of the lower extremities (HP:0008968)5.00874610
13Premature rupture of membranes (HP:0001788)4.95546462
14Syncope (HP:0001279)4.67210157
15Aortic aneurysm (HP:0004942)4.63696699
16Muscle fiber splitting (HP:0003555)4.50881077
17Type 1 muscle fiber predominance (HP:0003803)4.38830378
18Pulmonary artery stenosis (HP:0004415)4.36188279
19Dilated cardiomyopathy (HP:0001644)4.12417110
20Prolonged QT interval (HP:0001657)4.12038058
21Abnormality of the left ventricular outflow tract (HP:0011103)4.10889938
22Subaortic stenosis (HP:0001682)4.10889938
23Patent foramen ovale (HP:0001655)4.04578066
24Aortic dissection (HP:0002647)3.88652237
25Vascular tortuosity (HP:0004948)3.87090808
26Ankle contracture (HP:0006466)3.71611056
27Hyporeflexia of lower limbs (HP:0002600)3.68719159
28* Hypoplastic left heart (HP:0004383)3.67053772
29Aplasia cutis congenita (HP:0001057)3.64848526
30Ventricular arrhythmia (HP:0004308)3.56551194
31EMG: myopathic abnormalities (HP:0003458)3.45741228
32Exercise-induced muscle cramps (HP:0003710)3.38670625
33Follicular hyperkeratosis (HP:0007502)3.32712893
34Soft skin (HP:0000977)3.31811263
35Wormian bones (HP:0002645)3.16804580
36Bladder diverticulum (HP:0000015)3.15662719
37Mildly elevated creatine phosphokinase (HP:0008180)3.15036818
38Arterial tortuosity (HP:0005116)3.10996759
39Increased variability in muscle fiber diameter (HP:0003557)3.03440825
40Left ventricular hypertrophy (HP:0001712)3.02439118
41Neonatal short-limb short stature (HP:0008921)3.00128010
42* Hypoplastic heart (HP:0001961)2.91091860
43Heart block (HP:0012722)2.91015664
44Exercise-induced myalgia (HP:0003738)2.89716372
45Spinal rigidity (HP:0003306)2.87157243
46Atrioventricular block (HP:0001678)2.85352849
47Abnormal EKG (HP:0003115)2.84390874
48Wide anterior fontanel (HP:0000260)2.75532249
49Periauricular skin pits (HP:0100277)2.75109795
50Preauricular pit (HP:0004467)2.75109795
51Osteomalacia (HP:0002749)2.74698189
52Spondylolisthesis (HP:0003302)2.72765191
53Abnormal atrioventricular conduction (HP:0005150)2.69863617
54Increased connective tissue (HP:0009025)2.66435379
55Palpitations (HP:0001962)2.60218310
56Hypoplastic ischia (HP:0003175)2.57766590
57Transposition of the great arteries (HP:0001669)2.56289431
58Abnormal connection of the cardiac segments (HP:0011545)2.56289431
59Abnormal ventriculo-arterial connection (HP:0011563)2.56289431
60Aneurysm (HP:0002617)2.55039771
61Shallow orbits (HP:0000586)2.53261439
62Abnormality of skeletal muscle fiber size (HP:0012084)2.51901469
63Palmoplantar keratoderma (HP:0000982)2.51677143
64Atrophic scars (HP:0001075)2.46772431
65Dilatation of the ascending aorta (HP:0005111)2.44838790
66Abnormality of dentin (HP:0010299)2.43902064
67Bell-shaped thorax (HP:0001591)2.41831435
68Muscular dystrophy (HP:0003560)2.41388325
69Slender build (HP:0001533)2.39953505
70Absent frontal sinuses (HP:0002688)2.37741162
71Wrist flexion contracture (HP:0001239)2.37016822
72Coronal craniosynostosis (HP:0004440)2.32734962
73Midline defect of the nose (HP:0004122)2.32549219
74Bundle branch block (HP:0011710)2.30890659
75Fragile skin (HP:0001030)2.28653974
76Abnormality of the tricuspid valve (HP:0001702)2.27241536
77Mesomelia (HP:0003027)2.24529365
78Mitral valve prolapse (HP:0001634)2.23737370
79Cortical dysplasia (HP:0002539)2.21020212
80Double outlet right ventricle (HP:0001719)2.20959854
81Congenital malformation of the right heart (HP:0011723)2.20959854
82Bowel diverticulosis (HP:0005222)2.16662595
83Overgrowth (HP:0001548)2.16184817
84Abnormality of the right ventricle (HP:0001707)2.16044859
85Decreased circulating renin level (HP:0003351)2.15908193
86Abnormality of the ischium (HP:0003174)2.14823211
87Pulmonic stenosis (HP:0001642)2.12512775
88Blue sclerae (HP:0000592)2.08483713
89Peritonitis (HP:0002586)2.07313385
90Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.07245727
91Ulnar bowing (HP:0003031)2.07034585
92Elbow flexion contracture (HP:0002987)2.06195607
93Osteolytic defects of the hand bones (HP:0009699)2.05387048
94Osteolytic defects of the phalanges of the hand (HP:0009771)2.05387048
95Distal lower limb muscle weakness (HP:0009053)2.03434104
96Congestive heart failure (HP:0001635)2.02383158
97Neck muscle weakness (HP:0000467)2.02267709
98Preaxial foot polydactyly (HP:0001841)2.02141524
99Genu recurvatum (HP:0002816)2.01995676
100Asymmetric septal hypertrophy (HP:0001670)2.00872641
101Ventricular fibrillation (HP:0001663)2.00704596
102Centrally nucleated skeletal muscle fibers (HP:0003687)2.00087214
103Cervical subluxation (HP:0003308)1.99532694
104Limited hip movement (HP:0008800)1.98719300
105Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.98381627
106Hypoventilation (HP:0002791)1.98287495
107Skin pits (HP:0100276)1.96853657
108Bradycardia (HP:0001662)1.96220837
109Metaphyseal dysplasia (HP:0100255)1.96087774
110Cupped ribs (HP:0000887)1.95707420
111Persistence of primary teeth (HP:0006335)1.93933870
112Diaphragmatic weakness (HP:0009113)1.93269841
113Joint laxity (HP:0001388)1.92616182
114Generalized muscle weakness (HP:0003324)1.91161885
115Sparse lateral eyebrow (HP:0005338)1.90730862
116Mitral regurgitation (HP:0001653)1.86876343
117Adactyly (HP:0009776)1.85507636
118Sudden cardiac death (HP:0001645)1.85048545
119Mild short stature (HP:0003502)1.84377994
120Vascular calcification (HP:0004934)1.84170337
121Long toe (HP:0010511)1.83595231
122Hip contracture (HP:0003273)1.83248141
123Renal cortical cysts (HP:0000803)1.82346288
124Steppage gait (HP:0003376)1.81589957
125Rimmed vacuoles (HP:0003805)1.81054476
126Hyperextensible skin (HP:0000974)1.80395158
127Coarctation of aorta (HP:0001680)1.79995840
128Knee flexion contracture (HP:0006380)1.78993800
129Abnormality of incisor morphology (HP:0011063)1.76157626
130Biconcave vertebral bodies (HP:0004586)1.76149863
131EMG: neuropathic changes (HP:0003445)1.73938670
132Aortic valve stenosis (HP:0001650)1.73021134
133Cardiovascular calcification (HP:0011915)1.71350233
134Infantile muscular hypotonia (HP:0008947)1.70648083
135Abnormality of the lacrimal duct (HP:0011481)1.67117634
136Abnormality of the pubic bones (HP:0003172)1.65131814
137Abnormality of the nasolacrimal system (HP:0000614)1.63401106
138Skull defect (HP:0001362)1.60973834
139Short middle phalanx of the 5th finger (HP:0004220)1.57157172
140Myotonia (HP:0002486)1.54070622
141Abnormality of the foot musculature (HP:0001436)1.54032995
142Broad metatarsal (HP:0001783)1.53064036
143Absent eyebrow (HP:0002223)1.49028245
144Absent hand (HP:0004050)1.48178679
145Chromosomal breakage induced by crosslinking agents (HP:0003221)1.47494555
146Abnormality of the nasal septum (HP:0000419)1.45813209
147Abnormality of the endocardium (HP:0004306)1.44306405
148Gowers sign (HP:0003391)1.43416078
149White forelock (HP:0002211)1.41996838
150Septo-optic dysplasia (HP:0100842)1.41843590
151Duplicated collecting system (HP:0000081)1.40154420
152Nasolacrimal duct obstruction (HP:0000579)1.39266128
153Morphological abnormality of the middle ear (HP:0008609)1.38099324
154Foot dorsiflexor weakness (HP:0009027)1.38059904
155Scapular winging (HP:0003691)1.33465395
156Abnormality of molar morphology (HP:0011070)1.32265626
157Abnormality of molar (HP:0011077)1.32265626

Predicted kinase interactions (KEA)

RankGene SetZ-score
1OBSCN6.67940254
2MYLK4.18212947
3ZAK4.04093680
4PIK3CA3.36600254
5STK242.87070347
6DMPK2.83407998
7WNK42.65950654
8PDGFRA2.41191274
9CASK2.36986768
10NUAK12.14446805
11TTN2.11981157
12BCR2.02947332
13TIE12.00096763
14PKN21.91947789
15WNK11.84763075
16MAP3K51.72474670
17PHKG11.65598106
18PHKG21.65598106
19LATS11.64147727
20GRK71.61876680
21INSRR1.59157867
22AKT31.56329886
23LMTK21.56249244
24PTK21.55390466
25MUSK1.48883701
26FLT31.46551081
27MAPKAPK31.44075220
28SIK31.39704373
29PRPF4B1.38225024
30LATS21.36575392
31STK381.32706359
32PAK31.30581245
33PRKD21.26377214
34BMPR1B1.26253209
35PKN11.21054741
36ROCK11.20775155
37STK38L1.17275778
38TGFBR21.15171831
39EPHB21.12407698
40CDC42BPA1.11374921
41MAP3K61.09138892
42PIM21.06234279
43MKNK21.05373549
44TESK11.01432355
45DAPK30.98945704
46ILK0.97373478
47TNIK0.92769928
48TRPM70.92553475
49CAMK2D0.91912009
50PRKCE0.90820279
51PDGFRB0.86377749
52MET0.85449886
53STK40.81669332
54PTK2B0.81543753
55YES10.80331121
56EIF2AK20.79189733
57ADRBK20.77769808
58SGK20.76871407
59TRIB30.73118083
60CAMK2A0.70266899
61MKNK10.69957852
62PRKD10.69870554
63PRKG10.69287543
64PLK20.68577242
65KIT0.66291910
66EPHB10.64320555
67ROCK20.64133935
68MAPK120.63919856
69MTOR0.63775372
70MELK0.63305350
71MAPK70.62186618
72CDK80.62111335
73BLK0.60530252
74CLK10.60166672
75RIPK10.59909041
76GRK10.57145874
77RPS6KA20.57134020
78NTRK10.56932237
79ERBB40.56469211
80PRKACB0.56255624
81MAP2K10.54995718
82MARK10.54963014
83CAMK2G0.54853238
84BMPR20.52587410
85JAK10.52471557
86PINK10.52373702
87EEF2K0.52147474
88TEC0.51490260
89STK30.50302566
90CAMK10.49825961
91PAK20.48723959
92TXK0.48418693
93PRKACA0.48060045
94ERBB30.47964510
95MAPK40.47917965
96ADRBK10.47716064
97SIK10.46968444
98IRAK30.46917974
99PRKAA10.46238180
100MAP3K140.46006083
101NEK60.45721000
102RPS6KL10.44925865
103RPS6KC10.44925865
104PRKAA20.44612664
105MAP2K70.44038089
106SGK10.43326856
107ABL20.43318172
108GSK3A0.42281079
109SGK30.41208143
110NLK0.41119653
111PRKCQ0.41009292
112DDR20.39775213
113PAK60.39421325
114MOS0.38996591
115RPS6KA60.38578551
116GRK50.38127598
117SGK4940.37959030
118SGK2230.37959030
119PAK40.36862091
120MARK30.36686922
121RET0.35308701
122CCNB10.35280890
123MAP3K70.35228902
124FER0.34580388
125EPHA30.33880029
126ICK0.33852646
127NEK90.33475204
128PRKG20.32826187
129RAF10.31911982
130LIMK10.31558672
131PIK3CG0.30925158
132CAMK40.30374530
133PDK40.28639378
134PDK30.28639378
135PAK10.28634694
136MAPK130.28616393
137TGFBR10.27158506
138DYRK1B0.26468564
139PRKACG0.26193443
140PDK20.26090333
141FGFR10.25106074
142IRAK40.24289154

Predicted pathways (KEGG)

RankGene SetZ-score
1Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054105.45462914
2Dilated cardiomyopathy_Homo sapiens_hsa054145.16221183
3Cardiac muscle contraction_Homo sapiens_hsa042604.78133600
4Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054123.89470752
5Viral myocarditis_Homo sapiens_hsa054162.21243941
6Oxidative phosphorylation_Homo sapiens_hsa001902.13958515
7Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042612.00670372
8Parkinsons disease_Homo sapiens_hsa050121.97923713
9Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.75308494
10cGMP-PKG signaling pathway_Homo sapiens_hsa040221.73851159
11ECM-receptor interaction_Homo sapiens_hsa045121.67094238
12Alzheimers disease_Homo sapiens_hsa050101.65261980
13Adherens junction_Homo sapiens_hsa045201.58029728
14Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.55472547
15Vascular smooth muscle contraction_Homo sapiens_hsa042701.54561665
16Leukocyte transendothelial migration_Homo sapiens_hsa046701.45769744
17Focal adhesion_Homo sapiens_hsa045101.43332826
18Huntingtons disease_Homo sapiens_hsa050161.34838253
19Tight junction_Homo sapiens_hsa045301.34456784
20Axon guidance_Homo sapiens_hsa043601.31968964
21Basal cell carcinoma_Homo sapiens_hsa052171.27906984
22Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.26345984
23Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.23548918
24Oxytocin signaling pathway_Homo sapiens_hsa049211.19338443
25Calcium signaling pathway_Homo sapiens_hsa040201.17466980
26Circadian entrainment_Homo sapiens_hsa047131.16435157
27Regulation of actin cytoskeleton_Homo sapiens_hsa048101.06016472
28Wnt signaling pathway_Homo sapiens_hsa043101.02670595
29Hippo signaling pathway_Homo sapiens_hsa043901.00321509
30Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.97808456
31cAMP signaling pathway_Homo sapiens_hsa040240.95536525
32TGF-beta signaling pathway_Homo sapiens_hsa043500.91141661
33Melanoma_Homo sapiens_hsa052180.90609143
34Proteoglycans in cancer_Homo sapiens_hsa052050.90564928
35Morphine addiction_Homo sapiens_hsa050320.87000317
36HIF-1 signaling pathway_Homo sapiens_hsa040660.86876822
37Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.86362603
38Malaria_Homo sapiens_hsa051440.85766462
39Taste transduction_Homo sapiens_hsa047420.85359808
40Fatty acid elongation_Homo sapiens_hsa000620.84607398
41Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.84072249
42Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.83931407
43Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.82747738
44Melanogenesis_Homo sapiens_hsa049160.82537776
45Phospholipase D signaling pathway_Homo sapiens_hsa040720.82006804
46Cocaine addiction_Homo sapiens_hsa050300.80807364
47Amoebiasis_Homo sapiens_hsa051460.79629750
48Gastric acid secretion_Homo sapiens_hsa049710.78900881
49PPAR signaling pathway_Homo sapiens_hsa033200.78699567
50Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.77953113
51Longevity regulating pathway - mammal_Homo sapiens_hsa042110.75421415
52Renin secretion_Homo sapiens_hsa049240.74823862
53Pathways in cancer_Homo sapiens_hsa052000.74760270
54Serotonergic synapse_Homo sapiens_hsa047260.74181587
55Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.73870605
56Platelet activation_Homo sapiens_hsa046110.72155404
57Glycosaminoglycan degradation_Homo sapiens_hsa005310.71308196
58Dorso-ventral axis formation_Homo sapiens_hsa043200.69047113
59Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.68724520
60PI3K-Akt signaling pathway_Homo sapiens_hsa041510.68506501
61Rheumatoid arthritis_Homo sapiens_hsa053230.68185311
62Leishmaniasis_Homo sapiens_hsa051400.67048931
63Complement and coagulation cascades_Homo sapiens_hsa046100.65572506
64Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.65517608
65Circadian rhythm_Homo sapiens_hsa047100.63925773
66Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.63751697
67Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.63147969
68Propanoate metabolism_Homo sapiens_hsa006400.60963735
69MicroRNAs in cancer_Homo sapiens_hsa052060.59515315
70Arachidonic acid metabolism_Homo sapiens_hsa005900.59304424
71Insulin secretion_Homo sapiens_hsa049110.58286512
72Ovarian steroidogenesis_Homo sapiens_hsa049130.56478765
73Insulin resistance_Homo sapiens_hsa049310.55889500
74Prion diseases_Homo sapiens_hsa050200.54764786
75MAPK signaling pathway_Homo sapiens_hsa040100.54114828
76Glucagon signaling pathway_Homo sapiens_hsa049220.53926367
77AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.52939602
78Pancreatic secretion_Homo sapiens_hsa049720.52187567
79Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.52081799
80Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.51892418
81Allograft rejection_Homo sapiens_hsa053300.51460640
82Thyroid hormone signaling pathway_Homo sapiens_hsa049190.51156128
83Salmonella infection_Homo sapiens_hsa051320.50430495
84Rap1 signaling pathway_Homo sapiens_hsa040150.50357101
85Hedgehog signaling pathway_Homo sapiens_hsa043400.49839763
86Prostate cancer_Homo sapiens_hsa052150.49287380
87Nicotine addiction_Homo sapiens_hsa050330.48584952
88GABAergic synapse_Homo sapiens_hsa047270.48207541
89NF-kappa B signaling pathway_Homo sapiens_hsa040640.47717759
90GnRH signaling pathway_Homo sapiens_hsa049120.47029291
912-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.45744970
92Bile secretion_Homo sapiens_hsa049760.45686486
93Central carbon metabolism in cancer_Homo sapiens_hsa052300.45654364
94Small cell lung cancer_Homo sapiens_hsa052220.45588725
95Graft-versus-host disease_Homo sapiens_hsa053320.45475486
96FoxO signaling pathway_Homo sapiens_hsa040680.45280816
97Olfactory transduction_Homo sapiens_hsa047400.44815873
98Sphingolipid metabolism_Homo sapiens_hsa006000.43044764
99Lysine degradation_Homo sapiens_hsa003100.41907237
100Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.41623183
101Ras signaling pathway_Homo sapiens_hsa040140.41524276
102Toxoplasmosis_Homo sapiens_hsa051450.41252817
103Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.40402236
104Thyroid hormone synthesis_Homo sapiens_hsa049180.40364064
105Insulin signaling pathway_Homo sapiens_hsa049100.40027288
106Mineral absorption_Homo sapiens_hsa049780.39756149
107Salivary secretion_Homo sapiens_hsa049700.39070524
108Bladder cancer_Homo sapiens_hsa052190.38565139
109Cholinergic synapse_Homo sapiens_hsa047250.38148405
110Long-term depression_Homo sapiens_hsa047300.36895024
111Autoimmune thyroid disease_Homo sapiens_hsa053200.36844835
112mTOR signaling pathway_Homo sapiens_hsa041500.36480536
113Renal cell carcinoma_Homo sapiens_hsa052110.35887150
114Toll-like receptor signaling pathway_Homo sapiens_hsa046200.35744050
115Fanconi anemia pathway_Homo sapiens_hsa034600.35699500
116Aldosterone synthesis and secretion_Homo sapiens_hsa049250.35510609
117Fatty acid degradation_Homo sapiens_hsa000710.35472973
118AMPK signaling pathway_Homo sapiens_hsa041520.35084073
119Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.34961207
120Transcriptional misregulation in cancer_Homo sapiens_hsa052020.34221563
121Amphetamine addiction_Homo sapiens_hsa050310.32760692
122Estrogen signaling pathway_Homo sapiens_hsa049150.32382668
123Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.32045874
124HTLV-I infection_Homo sapiens_hsa051660.31166678
125Glutamatergic synapse_Homo sapiens_hsa047240.30256052
126Adipocytokine signaling pathway_Homo sapiens_hsa049200.29929898
127Measles_Homo sapiens_hsa051620.29460925
128Sulfur metabolism_Homo sapiens_hsa009200.29200621
129Endometrial cancer_Homo sapiens_hsa052130.28250117
130Protein digestion and absorption_Homo sapiens_hsa049740.28084205
131Notch signaling pathway_Homo sapiens_hsa043300.28022078
132Dopaminergic synapse_Homo sapiens_hsa047280.27926680
133Gap junction_Homo sapiens_hsa045400.27081830
134Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.23602034
135Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.23326146
136Choline metabolism in cancer_Homo sapiens_hsa052310.23068298

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