TBX22

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. Mutations in this gene have been associated with the inherited X-linked disorder, Cleft palate with ankyloglossia, and it is believed to play a major role in human palatogenesis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1chromatin remodeling at centromere (GO:0031055)5.29167236
2CENP-A containing nucleosome assembly (GO:0034080)5.02912141
3establishment of integrated proviral latency (GO:0075713)4.99235101
4regulation of non-canonical Wnt signaling pathway (GO:2000050)4.97206606
5regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)4.88186791
6DNA replication checkpoint (GO:0000076)4.64974742
7histone exchange (GO:0043486)4.60250702
8establishment of protein localization to mitochondrial membrane (GO:0090151)4.57184661
9mesenchymal cell differentiation involved in renal system development (GO:2001012)4.56890915
10mesenchymal cell differentiation involved in kidney development (GO:0072161)4.56890915
11intra-S DNA damage checkpoint (GO:0031573)4.32473965
12presynaptic membrane assembly (GO:0097105)4.30555304
13DNA replication-dependent nucleosome assembly (GO:0006335)4.12992901
14DNA replication-dependent nucleosome organization (GO:0034723)4.12992901
15proteasome assembly (GO:0043248)4.11433380
16apoptotic DNA fragmentation (GO:0006309)4.01644591
17regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.90987173
18regulation of mitotic spindle checkpoint (GO:1903504)3.90987173
19DNA replication-independent nucleosome organization (GO:0034724)3.89023853
20DNA replication-independent nucleosome assembly (GO:0006336)3.89023853
21head development (GO:0060322)3.88805675
22positive regulation of inositol phosphate biosynthetic process (GO:0060732)3.87786838
23rRNA modification (GO:0000154)3.87483243
24establishment of viral latency (GO:0019043)3.85117561
25presynaptic membrane organization (GO:0097090)3.81987517
26regulation of meiosis I (GO:0060631)3.76453506
27postsynaptic membrane organization (GO:0001941)3.75678904
28DNA replication initiation (GO:0006270)3.72941525
29chaperone-mediated protein transport (GO:0072321)3.68052714
30rRNA methylation (GO:0031167)3.61611211
31regulation of helicase activity (GO:0051095)3.60993168
32telomere maintenance via telomerase (GO:0007004)3.58847585
33IMP biosynthetic process (GO:0006188)3.58588588
34regulation of posttranscriptional gene silencing (GO:0060147)3.56949788
35regulation of gene silencing by miRNA (GO:0060964)3.56949788
36regulation of gene silencing by RNA (GO:0060966)3.56949788
37neuron cell-cell adhesion (GO:0007158)3.56508490
38intraciliary transport (GO:0042073)3.56441097
39drinking behavior (GO:0042756)3.55650066
40exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.53934464
414-hydroxyproline metabolic process (GO:0019471)3.48348998
42negative regulation of synaptic transmission, GABAergic (GO:0032229)3.47720751
43male sex determination (GO:0030238)3.46696001
44regulation of nuclear cell cycle DNA replication (GO:0033262)3.41485778
45IMP metabolic process (GO:0046040)3.39114133
46negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.37179558
47regulation of male gonad development (GO:2000018)3.36006487
48nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.35014220
49pantothenate metabolic process (GO:0015939)3.33942691
50purine nucleobase biosynthetic process (GO:0009113)3.32906553
51positive regulation of action potential (GO:0045760)3.30146362
52reciprocal meiotic recombination (GO:0007131)3.29882872
53reciprocal DNA recombination (GO:0035825)3.29882872
54protein neddylation (GO:0045116)3.29301399
55urinary tract smooth muscle contraction (GO:0014848)3.28019683
56CTP metabolic process (GO:0046036)3.27994164
57CTP biosynthetic process (GO:0006241)3.27994164
58RNA-dependent DNA replication (GO:0006278)3.27735469
59protein localization to synapse (GO:0035418)3.26981342
60regulation of inositol phosphate biosynthetic process (GO:0010919)3.25669327
61DNA strand elongation involved in DNA replication (GO:0006271)3.25153347
62RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.24996495
63spliceosomal snRNP assembly (GO:0000387)3.23621586
64polyketide metabolic process (GO:0030638)3.23543796
65doxorubicin metabolic process (GO:0044598)3.23543796
66daunorubicin metabolic process (GO:0044597)3.23543796
67axonal fasciculation (GO:0007413)3.21443407
68negative regulation of DNA-dependent DNA replication (GO:2000104)3.21238503
69negative regulation of stem cell proliferation (GO:2000647)3.21007255
70positive regulation of meiosis (GO:0045836)3.20745361
71nucleobase biosynthetic process (GO:0046112)3.20338794
72metanephric mesenchyme development (GO:0072075)3.19616240
73hyperosmotic salinity response (GO:0042538)3.18577290
74lateral sprouting from an epithelium (GO:0060601)3.17166950
75positive regulation of male gonad development (GO:2000020)3.16959503
76L-serine metabolic process (GO:0006563)3.14050646
77negative regulation of mitotic sister chromatid separation (GO:2000816)3.12764618
78negative regulation of sister chromatid segregation (GO:0033046)3.12764618
79negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.12764618
80negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.12764618
81negative regulation of mitotic sister chromatid segregation (GO:0033048)3.12764618
82kidney mesenchyme development (GO:0072074)3.12681289
83DNA double-strand break processing (GO:0000729)3.11507149
84limb bud formation (GO:0060174)3.10667081
85regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.09843478
86vocalization behavior (GO:0071625)3.08796178
87tRNA methylation (GO:0030488)3.08228471
88histone mRNA metabolic process (GO:0008334)3.07430691
89maturation of 5.8S rRNA (GO:0000460)3.06209424
90nodal signaling pathway (GO:0038092)3.04881184
91DNA deamination (GO:0045006)3.04836752
92regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.04643548
93non-recombinational repair (GO:0000726)3.04318309
94double-strand break repair via nonhomologous end joining (GO:0006303)3.04318309
95ATP-dependent chromatin remodeling (GO:0043044)3.03289314
96negative regulation of chromosome segregation (GO:0051985)3.02444080
97somatic hypermutation of immunoglobulin genes (GO:0016446)3.02059332
98somatic diversification of immune receptors via somatic mutation (GO:0002566)3.02059332
99regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)3.01550030
100gamma-aminobutyric acid transport (GO:0015812)3.00489309
101negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.99432139
102negative regulation of ligase activity (GO:0051352)2.99432139
103pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.98862463
104telomere maintenance via semi-conservative replication (GO:0032201)2.98321056
105positive regulation of meiotic cell cycle (GO:0051446)2.97595530
106cell differentiation involved in kidney development (GO:0061005)2.96752709
107DNA strand elongation (GO:0022616)2.96456979
108neuron recognition (GO:0008038)2.95429681
109ionotropic glutamate receptor signaling pathway (GO:0035235)2.93528941
110mesenchymal cell differentiation (GO:0048762)2.92640042
111regulation of cofactor metabolic process (GO:0051193)2.92564246
112regulation of coenzyme metabolic process (GO:0051196)2.92564246
113embryonic forelimb morphogenesis (GO:0035115)2.92004326
114pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.90606114
115regulation of mesoderm development (GO:2000380)2.89070944
116regulation of DNA endoreduplication (GO:0032875)2.88369009
117regulation of acyl-CoA biosynthetic process (GO:0050812)2.87914729
118positive regulation of synapse assembly (GO:0051965)2.87272279
119mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.86884737
120regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.86607023
121GTP biosynthetic process (GO:0006183)2.85749676
122inner ear receptor stereocilium organization (GO:0060122)2.83567035
123termination of RNA polymerase III transcription (GO:0006386)2.81584892
124transcription elongation from RNA polymerase III promoter (GO:0006385)2.81584892
125response to redox state (GO:0051775)2.78939719
126cullin deneddylation (GO:0010388)2.78050685
127female gonad development (GO:0008585)2.77841207
128otic vesicle formation (GO:0030916)2.77158885
129regulation of synapse assembly (GO:0051963)2.76987954
130histone H4-K12 acetylation (GO:0043983)2.76452132
131sex determination (GO:0007530)2.76007894
132middle ear morphogenesis (GO:0042474)2.75913809
133detection of calcium ion (GO:0005513)2.75793038
134double-strand break repair via homologous recombination (GO:0000724)2.75312043
135forelimb morphogenesis (GO:0035136)2.75231274
136anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.74544910
137recombinational repair (GO:0000725)2.73716822
138positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.73539422
139positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.73497827
140mitotic spindle checkpoint (GO:0071174)2.73236405
141telomere maintenance via telomere lengthening (GO:0010833)2.73216401
142positive regulation of synaptic transmission, GABAergic (GO:0032230)2.72970151
143positive regulation of catenin import into nucleus (GO:0035413)2.72490640
144negative regulation of cardiac muscle cell apoptotic process (GO:0010667)2.72329008
145regulation of cell fate specification (GO:0042659)2.71942943
146cell cycle G1/S phase transition (GO:0044843)2.71828205
147G1/S transition of mitotic cell cycle (GO:0000082)2.71828205
148regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.71715968
149pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)2.71608103
150G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.71369738
151bone trabecula formation (GO:0060346)2.71322244
152glutamate receptor signaling pathway (GO:0007215)2.71225380
153histone H2A acetylation (GO:0043968)2.68956775
154protein localization to kinetochore (GO:0034501)2.67815761
155gamma-aminobutyric acid signaling pathway (GO:0007214)2.67059370
156cerebral cortex radially oriented cell migration (GO:0021799)2.66623869
157pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.65418772
158negative regulation of chondrocyte differentiation (GO:0032331)2.64217128
159mesonephros development (GO:0001823)2.63881831
160convergent extension (GO:0060026)2.62458071
161negative regulation of myoblast differentiation (GO:0045662)2.59720902
162cornea development in camera-type eye (GO:0061303)2.59631070
163extracellular regulation of signal transduction (GO:1900115)2.56042021
164extracellular negative regulation of signal transduction (GO:1900116)2.56042021
165calcium ion import (GO:0070509)2.52113967
166cilium or flagellum-dependent cell motility (GO:0001539)2.51381211
167L-amino acid import (GO:0043092)2.49310176
168cardiac left ventricle morphogenesis (GO:0003214)2.48889034
169neuron remodeling (GO:0016322)2.48448350
170chondrocyte development (GO:0002063)2.47930450
171righting reflex (GO:0060013)2.47597797
172positive regulation of cardiac muscle cell differentiation (GO:2000727)2.46252410
173positive regulation of uterine smooth muscle contraction (GO:0070474)2.46209139
174synaptic transmission, glutamatergic (GO:0035249)2.44841824
175regulation of glutamate receptor signaling pathway (GO:1900449)2.44512389
176mesenchymal to epithelial transition (GO:0060231)2.42715725
177planar cell polarity pathway involved in neural tube closure (GO:0090179)2.41924197
178auditory receptor cell stereocilium organization (GO:0060088)2.41829219
179mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.41148577
180regulation of mesonephros development (GO:0061217)2.41033310
181regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.38121537
182negative regulation of keratinocyte proliferation (GO:0010839)2.37794761
183startle response (GO:0001964)2.37074916
184DNA integration (GO:0015074)2.34811108
185neuron-neuron synaptic transmission (GO:0007270)2.34040667
186negative regulation of axon extension involved in axon guidance (GO:0048843)2.32609843
187membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.32291206
188appendage development (GO:0048736)2.31921935
189limb development (GO:0060173)2.31921935
190neurotransmitter-gated ion channel clustering (GO:0072578)2.31737879
191regulation of glutamate secretion (GO:0014048)2.30994265
192regulation of synaptic transmission, GABAergic (GO:0032228)2.30818605
193response to auditory stimulus (GO:0010996)2.29625718
194calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.29392537
195G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.28940069
196regulation of timing of cell differentiation (GO:0048505)2.28866302
197negative regulation of axon guidance (GO:1902668)2.28496636
198positive regulation of smoothened signaling pathway (GO:0045880)2.27393364
199regulation of penile erection (GO:0060405)2.25876660
200central nervous system projection neuron axonogenesis (GO:0021952)2.25030872

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.91344556
2EZH2_22144423_ChIP-Seq_EOC_Human4.77168677
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.90166870
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.71961955
5GABP_17652178_ChIP-ChIP_JURKAT_Human3.52333825
6GBX2_23144817_ChIP-Seq_PC3_Human3.45461899
7EST1_17652178_ChIP-ChIP_JURKAT_Human3.19016525
8MYCN_21190229_ChIP-Seq_SHEP-21N_Human3.09283781
9GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.89877181
10JARID2_20064375_ChIP-Seq_MESCs_Mouse2.83172334
11EED_16625203_ChIP-ChIP_MESCs_Mouse2.80030980
12MYC_18555785_ChIP-Seq_MESCs_Mouse2.75237094
13EZH2_27304074_Chip-Seq_ESCs_Mouse2.73203460
14SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.67076799
15SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.66025207
16ELK1_19687146_ChIP-ChIP_HELA_Human2.54236142
17SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.46621713
18AR_21909140_ChIP-Seq_LNCAP_Human2.44431520
19EZH2_18974828_ChIP-Seq_MESCs_Mouse2.44341906
20RNF2_18974828_ChIP-Seq_MESCs_Mouse2.44341906
21CBX2_27304074_Chip-Seq_ESCs_Mouse2.41400308
22* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.41101262
23SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.36563548
24BMI1_23680149_ChIP-Seq_NPCS_Mouse2.36171465
25GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.34936312
26CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.33875532
27JARID2_20075857_ChIP-Seq_MESCs_Mouse2.30865960
28KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.23501505
29KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.23501505
30KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.23501505
31ZFP57_27257070_Chip-Seq_ESCs_Mouse2.22846222
32* EWS_26573619_Chip-Seq_HEK293_Human2.21286167
33RNF2_27304074_Chip-Seq_ESCs_Mouse2.17935365
34HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.13791097
35EZH2_27294783_Chip-Seq_ESCs_Mouse2.04370791
36PADI4_21655091_ChIP-ChIP_MCF-7_Human2.01966648
37TAF15_26573619_Chip-Seq_HEK293_Human2.01827319
38RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.96658107
39CREB1_15753290_ChIP-ChIP_HEK293T_Human1.94738119
40MYC_19030024_ChIP-ChIP_MESCs_Mouse1.94677292
41NANOG_16153702_ChIP-ChIP_HESCs_Human1.93871995
42PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.92129672
43JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.92041450
44KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.91189676
45SUZ12_27294783_Chip-Seq_ESCs_Mouse1.90965974
46AR_21572438_ChIP-Seq_LNCaP_Human1.89261450
47PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.89199544
48MTF2_20144788_ChIP-Seq_MESCs_Mouse1.88663270
49ETS1_20019798_ChIP-Seq_JURKAT_Human1.87873627
50IGF1R_20145208_ChIP-Seq_DFB_Human1.87116339
51CTBP1_25329375_ChIP-Seq_LNCAP_Human1.87013960
52CTBP2_25329375_ChIP-Seq_LNCAP_Human1.86070485
53NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.85289240
54RNF2_27304074_Chip-Seq_NSC_Mouse1.83203141
55FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.80992697
56SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.76130398
57P300_19829295_ChIP-Seq_ESCs_Human1.74995640
58E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.73897431
59SMAD_19615063_ChIP-ChIP_OVARY_Human1.71238720
60VDR_23849224_ChIP-Seq_CD4+_Human1.68749634
61MYC_19079543_ChIP-ChIP_MESCs_Mouse1.67524487
62SOX2_16153702_ChIP-ChIP_HESCs_Human1.62232284
63PIAS1_25552417_ChIP-Seq_VCAP_Human1.61846665
64NELFA_20434984_ChIP-Seq_ESCs_Mouse1.61313182
65SALL1_21062744_ChIP-ChIP_HESCs_Human1.59149850
66ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.58825494
67FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.58525455
68SMAD3_21741376_ChIP-Seq_EPCs_Human1.57043730
69E2F1_18555785_ChIP-Seq_MESCs_Mouse1.56945532
70CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.56225125
71CDX2_19796622_ChIP-Seq_MESCs_Mouse1.54545230
72VDR_22108803_ChIP-Seq_LS180_Human1.53984853
73MYC_18358816_ChIP-ChIP_MESCs_Mouse1.53656254
74NANOG_18555785_Chip-Seq_ESCs_Mouse1.50639061
75SMAD4_21799915_ChIP-Seq_A2780_Human1.49881346
76EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.49488639
77FUS_26573619_Chip-Seq_HEK293_Human1.49260490
78HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.48368896
79POU3F2_20337985_ChIP-ChIP_501MEL_Human1.47888608
80SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.47266534
81CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.46552282
82TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.45979617
83SOX2_18555785_ChIP-Seq_MESCs_Mouse1.45365753
84TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.43834585
85TOP2B_26459242_ChIP-Seq_MCF-7_Human1.43503650
86EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.43174635
87PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.42978829
88TP53_18474530_ChIP-ChIP_U2OS_Human1.42573652
89PCGF2_27294783_Chip-Seq_ESCs_Mouse1.40353516
90CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.40082780
91FOXP3_21729870_ChIP-Seq_TREG_Human1.39701647
92THAP11_20581084_ChIP-Seq_MESCs_Mouse1.38679893
93MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.38638648
94GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.38052616
95MYCN_18555785_ChIP-Seq_MESCs_Mouse1.36586458
96TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.36381653
97POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.36381653
98SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.36158166
99NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.36105845
100HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.34849425
101SUZ12_27294783_Chip-Seq_NPCs_Mouse1.34835569
102DROSHA_22980978_ChIP-Seq_HELA_Human1.34317438
103REST_21632747_ChIP-Seq_MESCs_Mouse1.32895043
104E2F1_18555785_Chip-Seq_ESCs_Mouse1.29988395
105NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.29920658
106PCGF2_27294783_Chip-Seq_NPCs_Mouse1.29755586
107POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.29425258
108P53_22387025_ChIP-Seq_ESCs_Mouse1.29103093
109NR3C1_21868756_ChIP-Seq_MCF10A_Human1.29050365
110FLI1_27457419_Chip-Seq_LIVER_Mouse1.27676802
111POU5F1_16153702_ChIP-ChIP_HESCs_Human1.27538289
112NFE2_27457419_Chip-Seq_LIVER_Mouse1.24956665
113E2F1_21310950_ChIP-Seq_MCF-7_Human1.24895167
114AR_25329375_ChIP-Seq_VCAP_Human1.24692993
115MYC_18940864_ChIP-ChIP_HL60_Human1.22828817
116ER_23166858_ChIP-Seq_MCF-7_Human1.20374638
117CMYC_18555785_Chip-Seq_ESCs_Mouse1.20162997
118UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.18977771
119* RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.18464319
120POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.18443012
121GABP_19822575_ChIP-Seq_HepG2_Human1.18244526
122SUZ12_18555785_Chip-Seq_ESCs_Mouse1.17906375
123RING1B_27294783_Chip-Seq_ESCs_Mouse1.17881280
124TTF2_22483619_ChIP-Seq_HELA_Human1.17280164
125BCAT_22108803_ChIP-Seq_LS180_Human1.17236280
126RUNX2_22187159_ChIP-Seq_PCA_Human1.15833500
127DCP1A_22483619_ChIP-Seq_HELA_Human1.15453875
128RBPJ_22232070_ChIP-Seq_NCS_Mouse1.15331923
129* STAT3_23295773_ChIP-Seq_U87_Human1.14582534
130ARNT_22903824_ChIP-Seq_MCF-7_Human1.14075618
131IKZF1_21737484_ChIP-ChIP_HCT116_Human1.13967085
132ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.13282606
133YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.13144979
134POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.12917057
135EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.12684688
136CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.12167097
137STAT3_18555785_Chip-Seq_ESCs_Mouse1.11901171
138TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.11762738
139IRF1_19129219_ChIP-ChIP_H3396_Human1.11342105
140STAT6_21828071_ChIP-Seq_BEAS2B_Human1.11164711
141AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.11090823
142EZH2_27294783_Chip-Seq_NPCs_Mouse1.10836474
143CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.10734545
144FOXM1_23109430_ChIP-Seq_U2OS_Human1.10542001
145CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.10150021
146ZNF274_21170338_ChIP-Seq_K562_Hela1.09477224
147TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.08903975
148OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.08630682
149TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08569725
150NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.08458631
151P300_18555785_Chip-Seq_ESCs_Mouse1.07969111
152SRF_21415370_ChIP-Seq_HL-1_Mouse1.06991922
153TP53_20018659_ChIP-ChIP_R1E_Mouse1.06873647
154* TCF4_23295773_ChIP-Seq_U87_Human1.06419035
155HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.06334451
156RING1B_27294783_Chip-Seq_NPCs_Mouse1.06026845
157P53_22127205_ChIP-Seq_FIBROBLAST_Human1.05067507
158MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.03937384
159EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.03632705
160AHR_22903824_ChIP-Seq_MCF-7_Human1.02787967
161LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02306705
162SOX2_18555785_Chip-Seq_ESCs_Mouse1.02272699
163ZNF217_24962896_ChIP-Seq_MCF-7_Human1.01691835
164HOXB4_20404135_ChIP-ChIP_EML_Mouse1.00664538
165TP63_19390658_ChIP-ChIP_HaCaT_Human0.98568657
166TCF3_18692474_ChIP-Seq_MEFs_Mouse0.95304888
167TP53_22573176_ChIP-Seq_HFKS_Human0.95105669
168AR_20517297_ChIP-Seq_VCAP_Human0.94584771
169IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.92551608
170CBP_20019798_ChIP-Seq_JUKART_Human0.92551608
171SOX2_19829295_ChIP-Seq_ESCs_Human0.92279096
172NANOG_19829295_ChIP-Seq_ESCs_Human0.92279096
173FOXA1_21572438_ChIP-Seq_LNCaP_Human0.90012276
174TCF3_18692474_ChIP-Seq_MESCs_Mouse0.85105028

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002254_reproductive_system_inflammat3.56925504
2MP0003693_abnormal_embryo_hatching3.16871132
3MP0004957_abnormal_blastocyst_morpholog3.13597543
4MP0010094_abnormal_chromosome_stability2.89648995
5MP0008058_abnormal_DNA_repair2.88162796
6MP0003890_abnormal_embryonic-extraembry2.81732046
7MP0002102_abnormal_ear_morphology2.71668102
8MP0003880_abnormal_central_pattern2.68741194
9MP0001188_hyperpigmentation2.45041587
10MP0005171_absent_coat_pigmentation2.44738833
11MP0003119_abnormal_digestive_system2.41647563
12MP0000566_synostosis2.31609253
13MP0008932_abnormal_embryonic_tissue2.25187185
14MP0003718_maternal_effect2.17773124
15MP0005377_hearing/vestibular/ear_phenot2.12185775
16MP0003878_abnormal_ear_physiology2.12185775
17MP0006072_abnormal_retinal_apoptosis2.10255767
18MP0005423_abnormal_somatic_nervous2.08289244
19MP0005646_abnormal_pituitary_gland2.04311145
20MP0000049_abnormal_middle_ear2.03804120
21MP0003283_abnormal_digestive_organ2.03188852
22MP0002396_abnormal_hematopoietic_system2.01196745
23MP0003385_abnormal_body_wall2.00528179
24MP0001293_anophthalmia1.98686651
25MP0002249_abnormal_larynx_morphology1.92355257
26MP0003077_abnormal_cell_cycle1.91690384
27MP0009745_abnormal_behavioral_response1.91420649
28MP0009046_muscle_twitch1.89864382
29MP0009672_abnormal_birth_weight1.89390320
30MP0004859_abnormal_synaptic_plasticity1.89091802
31MP0001486_abnormal_startle_reflex1.87024753
32MP0009250_abnormal_appendicular_skeleto1.84882871
33MP0005503_abnormal_tendon_morphology1.84860661
34MP0000569_abnormal_digit_pigmentation1.84663483
35MP0002735_abnormal_chemical_nociception1.83933588
36MP0003787_abnormal_imprinting1.81284314
37MP0004272_abnormal_basement_membrane1.79225406
38MP0003122_maternal_imprinting1.78479047
39MP0006292_abnormal_olfactory_placode1.78018455
40MP0002572_abnormal_emotion/affect_behav1.77056818
41MP0003635_abnormal_synaptic_transmissio1.73470617
42MP0009384_cardiac_valve_regurgitation1.68436299
43MP0001440_abnormal_grooming_behavior1.66210264
44MP0000778_abnormal_nervous_system1.65043123
45* MP0000762_abnormal_tongue_morphology1.64729725
46MP0002063_abnormal_learning/memory/cond1.63548481
47MP0003111_abnormal_nucleus_morphology1.60451635
48MP0003123_paternal_imprinting1.59743315
49MP0003786_premature_aging1.56988861
50MP0001968_abnormal_touch/_nociception1.56586304
51MP0005409_darkened_coat_color1.54511887
52MP0008004_abnormal_stomach_pH1.53471573
53MP0002064_seizures1.53221421
54MP0003941_abnormal_skin_development1.52875891
55MP0006276_abnormal_autonomic_nervous1.51398932
56MP0001730_embryonic_growth_arrest1.50831792
57MP0008007_abnormal_cellular_replicative1.49708269
58MP0010030_abnormal_orbit_morphology1.49483504
59MP0003937_abnormal_limbs/digits/tail_de1.48321149
60MP0002272_abnormal_nervous_system1.47887650
61MP0004133_heterotaxia1.47382484
62MP0001177_atelectasis1.44823113
63MP0002653_abnormal_ependyma_morphology1.43891920
64MP0008995_early_reproductive_senescence1.43335160
65MP0005645_abnormal_hypothalamus_physiol1.43047698
66MP0002277_abnormal_respiratory_mucosa1.42202629
67MP0003136_yellow_coat_color1.41918038
68MP0008057_abnormal_DNA_replication1.41850103
69MP0003567_abnormal_fetal_cardiomyocyte1.40150607
70MP0003938_abnormal_ear_development1.39735799
71MP0002067_abnormal_sensory_capabilities1.38522912
72MP0001984_abnormal_olfaction1.38401354
73MP0003879_abnormal_hair_cell1.38033933
74MP0000631_abnormal_neuroendocrine_gland1.37914315
75MP0005253_abnormal_eye_physiology1.37614382
76MP0002938_white_spotting1.37366475
77* MP0002233_abnormal_nose_morphology1.37178359
78MP0008877_abnormal_DNA_methylation1.36414999
79* MP0003755_abnormal_palate_morphology1.36392978
80MP0002736_abnormal_nociception_after1.35729504
81MP0009780_abnormal_chondrocyte_physiolo1.35243258
82MP0004742_abnormal_vestibular_system1.34127544
83MP0002751_abnormal_autonomic_nervous1.33804951
84MP0002085_abnormal_embryonic_tissue1.30120552
85MP0000026_abnormal_inner_ear1.30090689
86MP0001986_abnormal_taste_sensitivity1.27555723
87MP0002084_abnormal_developmental_patter1.25080896
88MP0003011_delayed_dark_adaptation1.25016282
89MP0001286_abnormal_eye_development1.24705609
90MP0000751_myopathy1.23101493
91MP0001501_abnormal_sleep_pattern1.22669983
92MP0002090_abnormal_vision1.21307275
93MP0002557_abnormal_social/conspecific_i1.20850069
94MP0000579_abnormal_nail_morphology1.20546064
95MP0000383_abnormal_hair_follicle1.20414515
96MP0004134_abnormal_chest_morphology1.19591802
97MP0002184_abnormal_innervation1.19030986
98MP0000350_abnormal_cell_proliferation1.17719248
99MP0000428_abnormal_craniofacial_morphol1.16032933
100MP0001963_abnormal_hearing_physiology1.15574461
101MP0001485_abnormal_pinna_reflex1.14877076
102MP0002734_abnormal_mechanical_nocicepti1.14390847
103* MP0002116_abnormal_craniofacial_bone1.14151299
104MP0004510_myositis1.12848104
105MP0004215_abnormal_myocardial_fiber1.12330319
106MP0006054_spinal_hemorrhage1.12179910
107MP0000678_abnormal_parathyroid_gland1.10124056
108MP0003646_muscle_fatigue1.09821837
109MP0000537_abnormal_urethra_morphology1.09189883
110MP0001697_abnormal_embryo_size1.07402278
111MP0002210_abnormal_sex_determination1.07241839
112MP0006036_abnormal_mitochondrial_physio1.06774631
113MP0001346_abnormal_lacrimal_gland1.05097842
114MP0009703_decreased_birth_body1.04208556
115MP0002160_abnormal_reproductive_system1.04072058
116MP0004381_abnormal_hair_follicle1.02874055
117MP0000516_abnormal_urinary_system1.02751883
118MP0005367_renal/urinary_system_phenotyp1.02751883
119MP0009697_abnormal_copulation1.02326981
120MP0001672_abnormal_embryogenesis/_devel1.01489332
121MP0005380_embryogenesis_phenotype1.01489332
122MP0001270_distended_abdomen1.00995885
123MP0000462_abnormal_digestive_system1.00935988
124MP0006035_abnormal_mitochondrial_morpho1.00853243
125MP0002111_abnormal_tail_morphology1.00711142
126MP0002697_abnormal_eye_size1.00548465
127MP0005257_abnormal_intraocular_pressure0.99795756
128MP0005551_abnormal_eye_electrophysiolog0.97979872
129MP0004484_altered_response_of0.97648497
130MP0001661_extended_life_span0.96936694
131MP0003121_genomic_imprinting0.96844252
132MP0002837_dystrophic_cardiac_calcinosis0.96609090
133MP0001929_abnormal_gametogenesis0.96066819
134MP0003315_abnormal_perineum_morphology0.95785844
135MP0004197_abnormal_fetal_growth/weight/0.94792179
136MP0001529_abnormal_vocalization0.93969514
137MP0001970_abnormal_pain_threshold0.93286146
138MP0000653_abnormal_sex_gland0.93274229
139MP0001764_abnormal_homeostasis0.92849700
140MP0004145_abnormal_muscle_electrophysio0.92251612
141MP0001145_abnormal_male_reproductive0.90611380
142MP0004142_abnormal_muscle_tone0.88836186
143MP0002080_prenatal_lethality0.87882024
144MP0003936_abnormal_reproductive_system0.87091529
145MP0003137_abnormal_impulse_conducting0.86895794
146MP0002876_abnormal_thyroid_physiology0.86779519
147MP0005391_vision/eye_phenotype0.86381980
148MP0000432_abnormal_head_morphology0.85542476
149MP0003183_abnormal_peptide_metabolism0.84171778
150MP0003984_embryonic_growth_retardation0.83042186
151MP0002088_abnormal_embryonic_growth/wei0.82963252
152MP0004270_analgesia0.82713671
153MP0003935_abnormal_craniofacial_develop0.82246185
154MP0002108_abnormal_muscle_morphology0.82231459
155MP0004264_abnormal_extraembryonic_tissu0.82181481
156MP0004085_abnormal_heartbeat0.82044716
157MP0002882_abnormal_neuron_morphology0.80935928
158MP0000613_abnormal_salivary_gland0.80935588
159MP0004885_abnormal_endolymph0.80646249
160MP0002127_abnormal_cardiovascular_syste0.80426996
161MP0003950_abnormal_plasma_membrane0.80185171
162MP0000358_abnormal_cell_content/0.78889337
163MP0003186_abnormal_redox_activity0.75961728
164MP0003698_abnormal_male_reproductive0.75233011
165MP0005410_abnormal_fertilization0.73732614
166MP0000470_abnormal_stomach_morphology0.70698117
167MP0003861_abnormal_nervous_system0.70331985
168MP0002796_impaired_skin_barrier0.66029518
169MP0001119_abnormal_female_reproductive0.64363178
170MP0005395_other_phenotype0.62820817

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the labia minora (HP:0012880)4.95135483
2Birth length less than 3rd percentile (HP:0003561)4.48756578
3Increased serum pyruvate (HP:0003542)4.15616408
4Cerebral palsy (HP:0100021)3.92617057
5Fibular aplasia (HP:0002990)3.87975439
6Fibular hypoplasia (HP:0003038)3.87813389
7Focal motor seizures (HP:0011153)3.82965137
8Bilateral microphthalmos (HP:0007633)3.72951465
9Abnormality of glycolysis (HP:0004366)3.70005248
10Multiple enchondromatosis (HP:0005701)3.64757310
11Hyperventilation (HP:0002883)3.58812083
12Septo-optic dysplasia (HP:0100842)3.53571614
13Aplasia/Hypoplasia of the fibula (HP:0006492)3.42743200
14Facial cleft (HP:0002006)3.30371273
15Abnormality of the parietal bone (HP:0002696)3.22841436
16Aplasia/Hypoplasia of the tibia (HP:0005772)3.19559708
17Short tibia (HP:0005736)3.19057730
18Epileptic encephalopathy (HP:0200134)3.17986783
19Congenital sensorineural hearing impairment (HP:0008527)3.14168879
20Febrile seizures (HP:0002373)3.11104148
21Bifid tongue (HP:0010297)3.10322878
22Atonic seizures (HP:0010819)3.07223100
23Abnormal sex determination (HP:0012244)3.03259605
24Sex reversal (HP:0012245)3.03259605
25Dynein arm defect of respiratory motile cilia (HP:0012255)2.97853868
26Absent/shortened dynein arms (HP:0200106)2.97853868
27Aplasia cutis congenita (HP:0001057)2.96603752
28Aplasia involving bones of the upper limbs (HP:0009823)2.88793666
29Aplasia of the phalanges of the hand (HP:0009802)2.88793666
30Aplasia involving bones of the extremities (HP:0009825)2.88793666
31Abnormal lung lobation (HP:0002101)2.84306323
32Asymmetry of the thorax (HP:0001555)2.80229629
33Short 4th metacarpal (HP:0010044)2.79946853
34Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.79946853
35Abnormal hair whorl (HP:0010721)2.75250610
36Oligodontia (HP:0000677)2.74142991
37Cutaneous finger syndactyly (HP:0010554)2.72736207
38Aplasia/Hypoplasia of the sternum (HP:0006714)2.63088669
39Morphological abnormality of the middle ear (HP:0008609)2.62582508
40Neoplasm of the colon (HP:0100273)2.60314069
41Hydroxyprolinuria (HP:0003080)2.57009171
42Abnormality of proline metabolism (HP:0010907)2.57009171
43Widely patent fontanelles and sutures (HP:0004492)2.56598629
44Abnormality of methionine metabolism (HP:0010901)2.55848777
45Abnormality of the fibula (HP:0002991)2.55622472
46Hypoglycemic seizures (HP:0002173)2.53205216
47Vitreoretinal degeneration (HP:0000655)2.49496006
48Abnormality of cochlea (HP:0000375)2.48620353
49Tetraparesis (HP:0002273)2.47739401
50Rectovaginal fistula (HP:0000143)2.45875942
51Rectal fistula (HP:0100590)2.45875942
52Abnormality of aspartate family amino acid metabolism (HP:0010899)2.42546966
53Tracheomalacia (HP:0002779)2.40298082
54Abnormality of serum amino acid levels (HP:0003112)2.39789980
55Osteomalacia (HP:0002749)2.39588164
56Anophthalmia (HP:0000528)2.38952305
57Abnormal ciliary motility (HP:0012262)2.38707740
58Optic nerve hypoplasia (HP:0000609)2.36133048
59Stenosis of the external auditory canal (HP:0000402)2.35920136
60Wide cranial sutures (HP:0010537)2.34837748
61White forelock (HP:0002211)2.33257214
62Parakeratosis (HP:0001036)2.30897430
63Methylmalonic aciduria (HP:0012120)2.30683132
64Absent septum pellucidum (HP:0001331)2.29465738
65Limited hip movement (HP:0008800)2.29053960
66Renal dysplasia (HP:0000110)2.26151682
67Cutaneous syndactyly (HP:0012725)2.25089292
68Exercise-induced muscle cramps (HP:0003710)2.24899210
69Anal stenosis (HP:0002025)2.24827454
70Aplasia/hypoplasia of the humerus (HP:0006507)2.24764304
71Absent radius (HP:0003974)2.24635147
72Increased hepatocellular lipid droplets (HP:0006565)2.23590382
73Patchy hypopigmentation of hair (HP:0011365)2.22819224
74Hypoplasia of the capital femoral epiphysis (HP:0003090)2.21319895
75Short humerus (HP:0005792)2.20503737
76Double outlet right ventricle (HP:0001719)2.20320358
77Congenital malformation of the right heart (HP:0011723)2.20320358
78Choanal stenosis (HP:0000452)2.17779204
79Lipid accumulation in hepatocytes (HP:0006561)2.14770849
80Cleft eyelid (HP:0000625)2.14071434
81Labial hypoplasia (HP:0000066)2.13465414
82Abnormality of the nasal septum (HP:0000419)2.13414320
83Nasolacrimal duct obstruction (HP:0000579)2.12466170
84Generalized tonic-clonic seizures (HP:0002069)2.12052096
85Overfolded helix (HP:0000396)2.11964322
86Progressive cerebellar ataxia (HP:0002073)2.11797160
87Aplasia involving forearm bones (HP:0009822)2.10262229
88Absent forearm bone (HP:0003953)2.10262229
89Hyperglycinuria (HP:0003108)2.09857903
90Midline defect of the nose (HP:0004122)2.09766710
91Colon cancer (HP:0003003)2.07071429
92Abnormality of homocysteine metabolism (HP:0010919)2.06279872
93Homocystinuria (HP:0002156)2.06279872
94Abnormality of the phalanges of the 2nd finger (HP:0009541)2.06174692
95Pancreatic islet-cell hyperplasia (HP:0004510)2.06095558
96Myelomeningocele (HP:0002475)2.06004855
97Hypoplastic female external genitalia (HP:0012815)2.03813263
98Megaloblastic anemia (HP:0001889)2.02398773
99Hyperinsulinemic hypoglycemia (HP:0000825)2.02328459
100Broad-based gait (HP:0002136)1.99907313
101Omphalocele (HP:0001539)1.98684519
102Thyroid-stimulating hormone excess (HP:0002925)1.98636429
103Humeroradial synostosis (HP:0003041)1.97773893
104Synostosis involving the elbow (HP:0003938)1.97773893
105Abnormality of the clitoris (HP:0000056)1.97427992
106Tubulointerstitial nephritis (HP:0001970)1.96503858
107Supernumerary ribs (HP:0005815)1.96177621
108Median cleft lip (HP:0000161)1.95898960
109Abnormality of glycine metabolism (HP:0010895)1.95827507
110Abnormality of serine family amino acid metabolism (HP:0010894)1.95827507
111Chromsome breakage (HP:0040012)1.95442827
112Aplasia/Hypoplasia of the clavicles (HP:0006710)1.94914790
113Decreased lacrimation (HP:0000633)1.94878443
114Long nose (HP:0003189)1.94228495
115Absent epiphyses (HP:0010577)1.93766870
116Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.93766870
117Abnormal respiratory epithelium morphology (HP:0012253)1.92855654
118Abnormal respiratory motile cilium morphology (HP:0005938)1.92855654
119Anal atresia (HP:0002023)1.92677692
120Short clavicles (HP:0000894)1.91467126
121Focal seizures (HP:0007359)1.91162775
122Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.91155757
123Abnormality of the nasolacrimal system (HP:0000614)1.90761090
124Abnormality of the calf musculature (HP:0001430)1.89620600
125Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.89453656
126Abnormal respiratory motile cilium physiology (HP:0012261)1.89021330
127Intestinal fistula (HP:0100819)1.88970502
128Abnormality of the septum pellucidum (HP:0007375)1.88558343
129Esophageal atresia (HP:0002032)1.88534821
130Absent eyebrow (HP:0002223)1.87776148
131Muscle stiffness (HP:0003552)1.87616091
132Absence seizures (HP:0002121)1.87240335
133Clitoromegaly (HP:0000057)1.87176326
134Vaginal atresia (HP:0000148)1.86679963
135Genital tract atresia (HP:0001827)1.86079513
1363-Methylglutaconic aciduria (HP:0003535)1.85071477
137Male pseudohermaphroditism (HP:0000037)1.84485183
138Vaginal fistula (HP:0004320)1.83869489
139Hypoglycemic coma (HP:0001325)1.83667210
140Narrow nasal bridge (HP:0000446)1.83619565
141Hypoplasia of the radius (HP:0002984)1.83213146
142Abnormality of the lacrimal duct (HP:0011481)1.82666469
143Syncope (HP:0001279)1.82090034
144Supernumerary spleens (HP:0009799)1.81874509
145Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.81861847
146Morphological abnormality of the inner ear (HP:0011390)1.81818372
147Decreased electroretinogram (ERG) amplitude (HP:0000654)1.81776280
148Short hallux (HP:0010109)1.79423569
149Lip pit (HP:0100267)1.79179627
150Chronic obstructive pulmonary disease (HP:0006510)1.78847439
151Obstructive lung disease (HP:0006536)1.78847439
152Decreased central vision (HP:0007663)1.78697070
153Microretrognathia (HP:0000308)1.78262175
154Acute necrotizing encephalopathy (HP:0006965)1.77591883
155Sparse eyelashes (HP:0000653)1.77458038
156Glossoptosis (HP:0000162)1.77311213
157Supernumerary bones of the axial skeleton (HP:0009144)1.76815194
158Nephroblastoma (Wilms tumor) (HP:0002667)1.76143341
159Chromosomal breakage induced by crosslinking agents (HP:0003221)1.75625021
160Meckel diverticulum (HP:0002245)1.74820243
161Hypoplastic labia majora (HP:0000059)1.74715050
162Abnormality of the vitamin B12 metabolism (HP:0004341)1.74401980
163Alacrima (HP:0000522)1.74217368
164Abnormally folded helix (HP:0008544)1.74129784
165Absent hair (HP:0002298)1.73994766
166Congenital, generalized hypertrichosis (HP:0004540)1.73489486
167Aplasia/Hypoplasia of the hallux (HP:0008362)1.71906230
168Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.71653850
169Acute encephalopathy (HP:0006846)1.71468208
170Protruding tongue (HP:0010808)1.69157867
171True hermaphroditism (HP:0010459)1.68933807
172Abolished electroretinogram (ERG) (HP:0000550)1.68549589
173Abnormality of secondary sexual hair (HP:0009888)1.68083222
174Abnormality of the axillary hair (HP:0100134)1.68083222
175Abnormality of the 4th metacarpal (HP:0010012)1.67949579
176Agnosia (HP:0010524)1.66815427
177Hypothermia (HP:0002045)1.66588449
178Abnormality of the labia (HP:0000058)1.66290438
179Symptomatic seizures (HP:0011145)1.65045746
180Abnormality of incisor morphology (HP:0011063)1.64775814
181Conical tooth (HP:0000698)1.63938008
182Horseshoe kidney (HP:0000085)1.63858495
183Methylmalonic acidemia (HP:0002912)1.63810811
184Hyperalaninemia (HP:0003348)1.63749130

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK4.77968730
2EPHA34.03878027
3ACVR1B3.57187404
4VRK22.88084402
5NTRK32.85740913
6PRPF4B2.72685253
7FLT32.72159403
8STK162.69028923
9CDC72.65684556
10BLK2.63519361
11TNIK2.60291077
12MAP4K22.59467812
13WEE12.53469326
14TSSK62.47250504
15WNK32.44335173
16PLK42.41965968
17PKN22.32169388
18EPHA42.29286092
19TLK12.29009369
20MAP2K72.26985817
21MKNK22.26613158
22NUAK12.16543270
23SIK32.15668000
24EIF2AK32.04789560
25PBK2.03175177
26BRSK21.96823541
27OBSCN1.85845661
28ZAK1.83925653
29MAPK131.81554952
30FGFR11.75384656
31INSRR1.70626748
32PLK31.68741598
33TTK1.64252673
34MAP3K41.60432396
35CDK31.59370011
36BUB11.55936427
37VRK11.53967228
38GRK11.53650221
39FRK1.50427699
40SGK21.47770860
41NME11.47086210
42NTRK21.46032384
43AKT31.44909644
44TAF11.36823865
45STK38L1.36077757
46BMPR1B1.35597593
47BRD41.33529014
48DDR21.32322665
49PLK11.31462879
50SIK21.29392729
51TGFBR11.24710395
52EPHB21.22061289
53MKNK11.19337743
54CDK191.19319125
55PLK21.19095637
56PKN11.18802739
57TRIM281.18197794
58BCR1.16817245
59MUSK1.16184706
60DMPK1.15069644
61MARK11.14788041
62TAOK21.14068824
63SGK2231.12041365
64SGK4941.12041365
65ERBB31.09911838
66CAMK1G1.09900494
67DYRK1A1.09242081
68WNK11.07715122
69NEK61.04577693
70PRKCE1.04207368
71ADRBK21.03754870
72SIK11.02726025
73PNCK1.01397616
74PINK10.99266175
75BCKDK0.97996812
76CDC42BPA0.97913642
77BRSK10.96602472
78CSNK1A1L0.96031064
79MAPK150.94860003
80OXSR10.94369238
81FGFR20.93923876
82MST40.93418858
83ERBB40.88640932
84FGR0.88358137
85EIF2AK20.87933495
86MARK20.83479486
87PDK20.81753186
88CAMK1D0.81488469
89CDK80.81321059
90CAMK2A0.80893682
91PRKD20.78945475
92BMPR20.76908578
93NLK0.76239757
94MAP3K120.75667736
95RIPK40.75661344
96PRKAA20.74782932
97STK240.73072654
98MAP3K140.72871590
99CHEK20.72056078
100PAK60.71816088
101CDK120.71384156
102MAP3K130.69766988
103PRKCG0.69547116
104SGK10.68805424
105PTK2B0.68597254
106CAMK10.65865469
107FES0.65395828
108PAK40.65340140
109EIF2AK10.61726582
110CSNK1G10.59393955
111GRK50.59390042
112ADRBK10.59151861
113NEK20.59102771
114NEK10.58205533
115LATS20.58175332
116CAMK2D0.58173882
117ATM0.57759340
118CAMK2B0.57222119
119PRKG10.56695122
120AURKB0.56223335
121SGK30.56021381
122WNK40.53047673
123MINK10.50452268
124PIK3CG0.50263963
125DAPK10.50229760
126CSNK1G20.49641353
127MAPK70.49620212
128PRKACA0.48413552
129MELK0.48306079
130CHEK10.47766358
131DYRK20.47685776
132CDK70.47556498
133PRKCH0.46722888
134ROCK10.45930763
135CSNK2A10.44864959
136STK390.44469236
137AURKA0.44442050
138PIK3CA0.44205551
139ATR0.42941589
140CCNB10.42921437
141CDK50.42670081
142STK40.42667041
143CSNK1G30.41781151
144PAK30.41684332
145UHMK10.41674024
146SRPK10.41555864
147TIE10.41351346
148CSNK2A20.40553353
149LATS10.40019744
150PRKACB0.39983522
151ALK0.38771544
152CSNK1E0.38257612
153PRKCB0.37136226
154PRKDC0.34961381
155ICK0.33860673
156ILK0.33791101
157IRAK10.33044542
158CDK10.31087481
159PRKCQ0.30742604
160TEC0.30659382
161RPS6KA50.30082519
162YES10.29825864
163MAP3K50.27937789
164FER0.27701647
165MYLK0.27285047
166CSNK1A10.24066361
167CDK20.23647046
168STK30.22314561

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.50876696
2Proteasome_Homo sapiens_hsa030503.58056106
3Non-homologous end-joining_Homo sapiens_hsa034503.40339580
4Mismatch repair_Homo sapiens_hsa034303.01970540
5DNA replication_Homo sapiens_hsa030302.99403117
6Protein export_Homo sapiens_hsa030602.92150644
7Asthma_Homo sapiens_hsa053102.87199946
8Homologous recombination_Homo sapiens_hsa034402.74892711
9Taste transduction_Homo sapiens_hsa047422.71054608
10Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.61191540
11Morphine addiction_Homo sapiens_hsa050322.59301670
12Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.59071889
13Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.49708779
14Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.47261072
15Pyruvate metabolism_Homo sapiens_hsa006202.33184526
16Propanoate metabolism_Homo sapiens_hsa006402.31907468
17GABAergic synapse_Homo sapiens_hsa047272.31497900
18Circadian entrainment_Homo sapiens_hsa047132.27843510
19Renin secretion_Homo sapiens_hsa049242.27607865
20Glutamatergic synapse_Homo sapiens_hsa047242.25597666
21Axon guidance_Homo sapiens_hsa043602.21734737
22RNA polymerase_Homo sapiens_hsa030202.12710117
23Phototransduction_Homo sapiens_hsa047442.10684180
24Selenocompound metabolism_Homo sapiens_hsa004502.06838375
25RNA degradation_Homo sapiens_hsa030182.00324006
26Allograft rejection_Homo sapiens_hsa053301.96118623
27Calcium signaling pathway_Homo sapiens_hsa040201.95900306
28Serotonergic synapse_Homo sapiens_hsa047261.95566255
29Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.88390658
30Graft-versus-host disease_Homo sapiens_hsa053321.87968303
31Type I diabetes mellitus_Homo sapiens_hsa049401.83926036
32Amphetamine addiction_Homo sapiens_hsa050311.81026927
33RNA transport_Homo sapiens_hsa030131.77981514
34Spliceosome_Homo sapiens_hsa030401.73477495
35Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.72723699
36Insulin secretion_Homo sapiens_hsa049111.69386616
37Cysteine and methionine metabolism_Homo sapiens_hsa002701.68607055
38Salivary secretion_Homo sapiens_hsa049701.66199814
39Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.58369168
40Cell cycle_Homo sapiens_hsa041101.55673083
41Intestinal immune network for IgA production_Homo sapiens_hsa046721.55239077
42Collecting duct acid secretion_Homo sapiens_hsa049661.53804097
43Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.49205778
44Long-term depression_Homo sapiens_hsa047301.49100439
45Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.49039532
46Olfactory transduction_Homo sapiens_hsa047401.49025371
47Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.48418077
48cAMP signaling pathway_Homo sapiens_hsa040241.47054969
49Oxytocin signaling pathway_Homo sapiens_hsa049211.45126519
50Dorso-ventral axis formation_Homo sapiens_hsa043201.44741418
51Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.44198030
52Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.41192889
53Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.39339366
54Wnt signaling pathway_Homo sapiens_hsa043101.38179726
55Synaptic vesicle cycle_Homo sapiens_hsa047211.34777658
56Basal cell carcinoma_Homo sapiens_hsa052171.34110929
57Parkinsons disease_Homo sapiens_hsa050121.32053399
58Vascular smooth muscle contraction_Homo sapiens_hsa042701.29250371
59Dopaminergic synapse_Homo sapiens_hsa047281.28123349
60Long-term potentiation_Homo sapiens_hsa047201.27252446
61Base excision repair_Homo sapiens_hsa034101.26549153
62Antigen processing and presentation_Homo sapiens_hsa046121.26275656
63Tryptophan metabolism_Homo sapiens_hsa003801.25042025
64Dilated cardiomyopathy_Homo sapiens_hsa054141.23239402
65Hedgehog signaling pathway_Homo sapiens_hsa043401.22249817
66Cocaine addiction_Homo sapiens_hsa050301.22200523
67Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.20793910
68Aldosterone synthesis and secretion_Homo sapiens_hsa049251.20588336
69cGMP-PKG signaling pathway_Homo sapiens_hsa040221.19119223
70Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.18029290
71Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.17791041
72Systemic lupus erythematosus_Homo sapiens_hsa053221.12190035
73Pyrimidine metabolism_Homo sapiens_hsa002401.07189717
74Cholinergic synapse_Homo sapiens_hsa047251.06213523
75Arginine and proline metabolism_Homo sapiens_hsa003301.05847457
76Circadian rhythm_Homo sapiens_hsa047101.05778616
77Nucleotide excision repair_Homo sapiens_hsa034201.05386904
78Viral myocarditis_Homo sapiens_hsa054161.03598953
79Basal transcription factors_Homo sapiens_hsa030221.03506871
80Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.02843552
81Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.99982285
82Steroid biosynthesis_Homo sapiens_hsa001000.99040479
83Ovarian steroidogenesis_Homo sapiens_hsa049130.97757361
84Gastric acid secretion_Homo sapiens_hsa049710.97576024
85Ribosome_Homo sapiens_hsa030100.94891895
86One carbon pool by folate_Homo sapiens_hsa006700.93917683
87Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.93367844
88Cardiac muscle contraction_Homo sapiens_hsa042600.92687183
89Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.92324197
90Biosynthesis of amino acids_Homo sapiens_hsa012300.91917157
91Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.90790780
92Vitamin digestion and absorption_Homo sapiens_hsa049770.90680934
93Melanogenesis_Homo sapiens_hsa049160.90656048
94mRNA surveillance pathway_Homo sapiens_hsa030150.90065386
95beta-Alanine metabolism_Homo sapiens_hsa004100.89924271
96Purine metabolism_Homo sapiens_hsa002300.87688115
97Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.87084394
98Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.86624720
99Carbon metabolism_Homo sapiens_hsa012000.84675163
100Melanoma_Homo sapiens_hsa052180.83374415
101Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.81812904
102Sphingolipid metabolism_Homo sapiens_hsa006000.81783237
103Histidine metabolism_Homo sapiens_hsa003400.81012040
104Ras signaling pathway_Homo sapiens_hsa040140.80228352
105Staphylococcus aureus infection_Homo sapiens_hsa051500.78631185
106MAPK signaling pathway_Homo sapiens_hsa040100.77343884
107Fatty acid degradation_Homo sapiens_hsa000710.76883929
108GnRH signaling pathway_Homo sapiens_hsa049120.75797495
109Protein digestion and absorption_Homo sapiens_hsa049740.75792820
110Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.74937994
111Mineral absorption_Homo sapiens_hsa049780.73901945
112Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.73715846
113Autoimmune thyroid disease_Homo sapiens_hsa053200.72738922
1142-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.72624119
115Oxidative phosphorylation_Homo sapiens_hsa001900.72346429
116Rap1 signaling pathway_Homo sapiens_hsa040150.70409524
117Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.70139411
118Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.69171319
119ECM-receptor interaction_Homo sapiens_hsa045120.68372605
120ErbB signaling pathway_Homo sapiens_hsa040120.67882889
121Vitamin B6 metabolism_Homo sapiens_hsa007500.67568009
122Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.65639812
123Phosphatidylinositol signaling system_Homo sapiens_hsa040700.65329158
124Pancreatic secretion_Homo sapiens_hsa049720.64435310
125Type II diabetes mellitus_Homo sapiens_hsa049300.63447653
126Gap junction_Homo sapiens_hsa045400.62817358
127Fatty acid elongation_Homo sapiens_hsa000620.62667435
128Oocyte meiosis_Homo sapiens_hsa041140.62659661
129Caffeine metabolism_Homo sapiens_hsa002320.61580928
130Vibrio cholerae infection_Homo sapiens_hsa051100.61298156
131Glutathione metabolism_Homo sapiens_hsa004800.60761170
132Rheumatoid arthritis_Homo sapiens_hsa053230.59675519
133Pentose and glucuronate interconversions_Homo sapiens_hsa000400.57315509
134Fatty acid biosynthesis_Homo sapiens_hsa000610.54771449
135Renin-angiotensin system_Homo sapiens_hsa046140.54098336
136African trypanosomiasis_Homo sapiens_hsa051430.53353152
137Alzheimers disease_Homo sapiens_hsa050100.52430562
138Fanconi anemia pathway_Homo sapiens_hsa034600.52333757
139Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.49985730
140Choline metabolism in cancer_Homo sapiens_hsa052310.49457055
141Steroid hormone biosynthesis_Homo sapiens_hsa001400.48820040
142Regulation of autophagy_Homo sapiens_hsa041400.47711356
143Retinol metabolism_Homo sapiens_hsa008300.47043346
144Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.46591701
145Regulation of actin cytoskeleton_Homo sapiens_hsa048100.46501083
146Metabolic pathways_Homo sapiens_hsa011000.45932270
147Epstein-Barr virus infection_Homo sapiens_hsa051690.45796234
148Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.45105270
149Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.44083904
150TGF-beta signaling pathway_Homo sapiens_hsa043500.43103205
151Ether lipid metabolism_Homo sapiens_hsa005650.42499120
152Sulfur relay system_Homo sapiens_hsa041220.41811789
153Folate biosynthesis_Homo sapiens_hsa007900.40914427
154alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.40362939
155Inositol phosphate metabolism_Homo sapiens_hsa005620.39386833
156Fatty acid metabolism_Homo sapiens_hsa012120.39341975
157Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.39050503
158Estrogen signaling pathway_Homo sapiens_hsa049150.37244125
159Huntingtons disease_Homo sapiens_hsa050160.37007956
160Hippo signaling pathway_Homo sapiens_hsa043900.36964084
161Phospholipase D signaling pathway_Homo sapiens_hsa040720.36784001
162Butanoate metabolism_Homo sapiens_hsa006500.35050905
163Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.33456088
164Tight junction_Homo sapiens_hsa045300.33389289
165Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.32881706
166Arachidonic acid metabolism_Homo sapiens_hsa005900.31733302
167Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.30256200
168Focal adhesion_Homo sapiens_hsa045100.29709972
169Lysine degradation_Homo sapiens_hsa003100.28945648
170Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.28493743
171PI3K-Akt signaling pathway_Homo sapiens_hsa041510.28447363
172Adherens junction_Homo sapiens_hsa045200.28011852
173Linoleic acid metabolism_Homo sapiens_hsa005910.27483007
174Chemical carcinogenesis_Homo sapiens_hsa052040.26477434
175Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.25055227
176Nitrogen metabolism_Homo sapiens_hsa009100.23777163

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