TBX21

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This gene is the human ortholog of mouse Tbx21/Tbet gene. Studies in mouse show that Tbx21 protein is a Th1 cell-specific transcription factor that controls the expression of the hallmark Th1 cytokine, interferon-gamma (IFNG). Expression of the human ortholog also correlates with IFNG expression in Th1 and natural killer cells, suggesting a role for this gene in initiating Th1 lineage development from naive Th precursor cells. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of cell killing (GO:0031342)8.97797304
2negative regulation of leukocyte mediated cytotoxicity (GO:0001911)8.97797304
3interferon-gamma production (GO:0032609)8.71890851
4antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G7.31434960
5negative T cell selection (GO:0043383)7.28586609
6positive regulation of gamma-delta T cell activation (GO:0046645)7.16350304
7negative thymic T cell selection (GO:0045060)7.03719137
8positive thymic T cell selection (GO:0045059)6.87205173
9regulation of gamma-delta T cell differentiation (GO:0045586)6.14549947
10positive T cell selection (GO:0043368)6.11608770
11response to interleukin-15 (GO:0070672)6.07077472
12regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)6.04571298
13cellular response to interleukin-15 (GO:0071350)5.90315661
14regulation of natural killer cell mediated cytotoxicity (GO:0042269)5.87405386
15regulation of natural killer cell mediated immunity (GO:0002715)5.87405386
16thymic T cell selection (GO:0045061)5.78130911
17T cell migration (GO:0072678)5.75546624
18regulation of gamma-delta T cell activation (GO:0046643)5.46518869
19* regulation of isotype switching to IgG isotypes (GO:0048302)5.41606306
20positive regulation of natural killer cell mediated immunity (GO:0002717)5.36299947
21positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)5.36299947
22activated T cell proliferation (GO:0050798)5.32334936
23T cell selection (GO:0045058)5.11297386
24negative regulation of T cell mediated immunity (GO:0002710)4.96635603
25regulation of B cell receptor signaling pathway (GO:0050855)4.92998318
26antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.76895185
27antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.76895185
28regulation of leukocyte mediated cytotoxicity (GO:0001910)4.70628943
29positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.68652002
30natural killer cell activation (GO:0030101)4.64245492
31positive regulation of leukocyte mediated cytotoxicity (GO:0001912)4.56266062
32macrophage activation involved in immune response (GO:0002281)4.38018271
33polyketide metabolic process (GO:0030638)4.32373625
34doxorubicin metabolic process (GO:0044598)4.32373625
35daunorubicin metabolic process (GO:0044597)4.32373625
36T cell costimulation (GO:0031295)4.31609209
37lymphocyte costimulation (GO:0031294)4.23308715
38positive regulation of humoral immune response (GO:0002922)4.22411096
39regulation of cell killing (GO:0031341)4.21179568
40antigen processing and presentation of endogenous antigen (GO:0019883)4.15980048
41leukocyte aggregation (GO:0070486)4.12540936
42positive regulation of interleukin-2 biosynthetic process (GO:0045086)4.11984705
43positive regulation of cell killing (GO:0031343)4.11333622
44negative regulation of lymphocyte mediated immunity (GO:0002707)4.10943427
45antigen processing and presentation via MHC class Ib (GO:0002475)4.10438717
46positive regulation of alpha-beta T cell proliferation (GO:0046641)4.08019862
47T cell receptor signaling pathway (GO:0050852)4.04678227
48* positive regulation of isotype switching (GO:0045830)4.00423274
49regulation of alpha-beta T cell proliferation (GO:0046640)3.98469704
50regulation of interleukin-2 biosynthetic process (GO:0045076)3.88038469
51positive regulation by symbiont of host defense response (GO:0052509)3.85129862
52modulation by symbiont of host defense response (GO:0052031)3.85129862
53modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.85129862
54modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.85129862
55positive regulation by organism of defense response of other organism involved in symbiotic interact3.85129862
56modulation by symbiont of host immune response (GO:0052553)3.85129862
57* positive regulation of B cell mediated immunity (GO:0002714)3.82179833
58* positive regulation of immunoglobulin mediated immune response (GO:0002891)3.82179833
59negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.80329186
60microglial cell activation (GO:0001774)3.80153610
61alpha-beta T cell activation involved in immune response (GO:0002287)3.76843692
62T cell differentiation involved in immune response (GO:0002292)3.76843692
63alpha-beta T cell differentiation involved in immune response (GO:0002293)3.76843692
64mast cell activation (GO:0045576)3.72072765
65cellular response to type I interferon (GO:0071357)3.71044184
66type I interferon signaling pathway (GO:0060337)3.71044184
67response to type I interferon (GO:0034340)3.70506519
68detection of bacterium (GO:0016045)3.70484305
69detection of other organism (GO:0098543)3.64227877
70myeloid cell activation involved in immune response (GO:0002275)3.63173066
71mast cell activation involved in immune response (GO:0002279)3.49196770
72mast cell degranulation (GO:0043303)3.49196770
73regulation of MHC class I biosynthetic process (GO:0045343)3.49191267
74immunoglobulin mediated immune response (GO:0016064)3.47744174
75T cell proliferation (GO:0042098)3.43143902
76antigen receptor-mediated signaling pathway (GO:0050851)3.42477007
77alpha-beta T cell activation (GO:0046631)3.42368773
78maintenance of protein location in nucleus (GO:0051457)3.41824582
79negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.40454547
80negative regulation of T-helper cell differentiation (GO:0045623)3.40454547
81* positive regulation of DNA recombination (GO:0045911)3.39969211
82regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.38787900
83B cell receptor signaling pathway (GO:0050853)3.38189260
84* regulation of immunoglobulin mediated immune response (GO:0002889)3.37713005
85regulation of T cell tolerance induction (GO:0002664)3.36173564
86regulation of B cell differentiation (GO:0045577)3.35936432
87regulation of interferon-gamma-mediated signaling pathway (GO:0060334)3.34228135
88tolerance induction (GO:0002507)3.32925867
89regulation of response to interferon-gamma (GO:0060330)3.32889140
90positive regulation of T cell mediated immunity (GO:0002711)3.31012974
91heterotypic cell-cell adhesion (GO:0034113)3.30527524
92regulation of tolerance induction (GO:0002643)3.30051983
93T-helper 1 type immune response (GO:0042088)3.29245648
94leukocyte degranulation (GO:0043299)3.28237824
95positive regulation of interleukin-2 production (GO:0032743)3.27893874
96leukocyte cell-cell adhesion (GO:0007159)3.27582461
97positive regulation of immune response to tumor cell (GO:0002839)3.27216386
98regulation of immune response to tumor cell (GO:0002837)3.27216386
99regulation of response to tumor cell (GO:0002834)3.27216386
100positive regulation of response to tumor cell (GO:0002836)3.27216386
101cytidine catabolic process (GO:0006216)3.26535318
102cytidine deamination (GO:0009972)3.26535318
103cytidine metabolic process (GO:0046087)3.26535318
104* regulation of B cell mediated immunity (GO:0002712)3.25000439
105T cell activation involved in immune response (GO:0002286)3.23900263
106defense response to protozoan (GO:0042832)3.22645447
107negative regulation of adaptive immune response based on somatic recombination of immune receptors b3.22235508
108interferon-gamma-mediated signaling pathway (GO:0060333)3.20914053
109regulation of T cell mediated immunity (GO:0002709)3.20633883
110regulation of regulatory T cell differentiation (GO:0045589)3.20400841
111negative regulation of interleukin-2 production (GO:0032703)3.18665125
112NIK/NF-kappaB signaling (GO:0038061)3.17655278
113negative regulation of interleukin-12 production (GO:0032695)3.15264514
114alpha-beta T cell differentiation (GO:0046632)3.15031333
115T cell homeostasis (GO:0043029)3.13362669
116regulation of T cell mediated cytotoxicity (GO:0001914)3.13218915
117negative regulation of protein oligomerization (GO:0032460)3.10590154
118cellular defense response (GO:0006968)3.10498318
119lymphocyte homeostasis (GO:0002260)3.09520844
120negative regulation of phagocytosis (GO:0050765)3.09006533
121regulation of T cell receptor signaling pathway (GO:0050856)3.08668232
122* lymphocyte migration (GO:0072676)3.08623738
123* regulation of isotype switching (GO:0045191)3.08187513
124positive regulation of interleukin-17 production (GO:0032740)3.07769692
125* regulation of lymphocyte mediated immunity (GO:0002706)3.06891646
126negative regulation of innate immune response (GO:0045824)3.04177344
127regulation of interleukin-12 biosynthetic process (GO:0045075)3.04114797
128neutrophil activation involved in immune response (GO:0002283)3.03444821
129negative regulation of alpha-beta T cell activation (GO:0046636)3.02854163
130* positive regulation of lymphocyte mediated immunity (GO:0002708)3.01687262
131negative regulation of leukocyte mediated immunity (GO:0002704)3.00717589
132lymph node development (GO:0048535)2.99644562
133positive regulation of T cell mediated cytotoxicity (GO:0001916)2.99498731
134CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.99301524
135T-helper cell differentiation (GO:0042093)2.99301524
136pyrimidine ribonucleoside catabolic process (GO:0046133)2.98494145
137negative regulation of T cell receptor signaling pathway (GO:0050860)2.97463618
138* positive regulation of leukocyte mediated immunity (GO:0002705)2.96887693
139positive regulation of tolerance induction (GO:0002645)2.94769860
140negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.94733810
141positive regulation of protein deacetylation (GO:0090312)2.94367224
142response to protozoan (GO:0001562)2.94333749
143positive regulation of mast cell activation (GO:0033005)2.93918893
144positive regulation of histone deacetylation (GO:0031065)2.92408562
145* T cell differentiation (GO:0030217)2.92036619
146somite rostral/caudal axis specification (GO:0032525)2.91416309
147* T cell activation (GO:0042110)2.90950506
148natural killer cell differentiation (GO:0001779)2.90488638
149regulation of interleukin-2 production (GO:0032663)2.89754685
150regulation of chronic inflammatory response (GO:0002676)2.87761824
151muscle organ morphogenesis (GO:0048644)2.87659452

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human5.19682916
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human5.09615577
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.87169730
4E2F7_22180533_ChIP-Seq_HELA_Human4.68684806
5MYC_22102868_ChIP-Seq_BL_Human3.49569206
6* STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.19623453
7RUNX_20019798_ChIP-Seq_JUKART_Human3.10535927
8IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.02728929
9STAT4_19710469_ChIP-ChIP_TH1__Mouse3.02407659
10FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.98563328
11KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.97711644
12KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.97711644
13KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.97711644
14MYB_26560356_Chip-Seq_TH2_Human2.89554034
15NOTCH1_21737748_ChIP-Seq_TLL_Human2.84096078
16SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.70061138
17MAF_26560356_Chip-Seq_TH1_Human2.54950576
18* MYB_26560356_Chip-Seq_TH1_Human2.52220985
19EGR1_19374776_ChIP-ChIP_THP-1_Human2.50478921
20IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.46627476
21CHD7_19251738_ChIP-ChIP_MESCs_Mouse2.46018120
22IRF8_22096565_ChIP-ChIP_GC-B_Human2.29803660
23UTX_26944678_Chip-Seq_JUKART_Human2.28302509
24NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.22221666
25MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.12597591
26TCF7_22412390_ChIP-Seq_EML_Mouse2.12577090
27SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.07280340
28NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.02846468
29TP63_19390658_ChIP-ChIP_HaCaT_Human1.99895948
30E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.95434899
31KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.91035379
32IRF8_21731497_ChIP-ChIP_J774_Mouse1.90105978
33RUNX1_22412390_ChIP-Seq_EML_Mouse1.84143130
34* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.79950096
35* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.78569862
36* LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.78373596
37MAF_26560356_Chip-Seq_TH2_Human1.76960978
38VDR_21846776_ChIP-Seq_THP-1_Human1.74830319
39* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.74813065
40IKZF1_21737484_ChIP-ChIP_HCT116_Human1.69381161
41E2F4_17652178_ChIP-ChIP_JURKAT_Human1.68332661
42* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.64496323
43SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.63184974
44GATA3_27048872_Chip-Seq_THYMUS_Human1.61392134
45SPI1_23547873_ChIP-Seq_NB4_Human1.57335001
46SCL_19346495_ChIP-Seq_HPC-7_Human1.52458112
47KDM2B_26808549_Chip-Seq_DND41_Human1.51382206
48FOXM1_23109430_ChIP-Seq_U2OS_Human1.51016194
49* GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.42833586
50SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.42698487
51IRF8_27001747_Chip-Seq_BMDM_Mouse1.41665496
52MYB_21317192_ChIP-Seq_ERMYB_Mouse1.40768973
53VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.40406175
54RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.37688728
55STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.36015235
56VDR_24787735_ChIP-Seq_THP-1_Human1.35725046
57CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.35145627
58SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.35041710
59ELK3_25401928_ChIP-Seq_HUVEC_Human1.31793429
60CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.31436277
61NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.30824728
62PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.30760210
63BRD4_27068464_Chip-Seq_AML-cells_Mouse1.29576352
64EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.28383759
65SPI1_23127762_ChIP-Seq_K562_Human1.27606112
66GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.25372033
67ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.23369384
68NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.22888566
69NCOR1_26117541_ChIP-Seq_K562_Human1.21949633
70GATA1_19941827_ChIP-Seq_MEL_Mouse1.21679464
71BCL6_27268052_Chip-Seq_Bcells_Human1.21107032
72HIF1A_21447827_ChIP-Seq_MCF-7_Human1.17916621
73FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.15212115
74SMAD_19615063_ChIP-ChIP_OVARY_Human1.14570393
75PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.13009054
76CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.12729077
77CIITA_25753668_ChIP-Seq_RAJI_Human1.11361159
78CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.09230557
79PU_27001747_Chip-Seq_BMDM_Mouse1.06496597
80* ELF1_20517297_ChIP-Seq_JURKAT_Human1.05289324
81BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.04529258
82NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.04230036
83KDM2B_26808549_Chip-Seq_JURKAT_Human1.03622678
84STAT3_1855785_ChIP-Seq_MESCs_Mouse1.02676219
85VDR_24763502_ChIP-Seq_THP-1_Human1.01647468
86RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.00371024
87GATA1_19941826_ChIP-Seq_K562_Human0.96135933
88FOXP3_21729870_ChIP-Seq_TREG_Human0.95533859
89FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.95471218
90ELF1_17652178_ChIP-ChIP_JURKAT_Human0.94812384
91RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.94246171
92RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.94170270
93EGR1_19032775_ChIP-ChIP_M12_Human0.93286361
94GATA3_26560356_Chip-Seq_TH2_Human0.92893546
95NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.92432973
96TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.92352178
97TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.92351606
98CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.90991480
99EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.90500050
100MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.90428188
101SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.90260614
102GATA1_22383799_ChIP-Seq_G1ME_Mouse0.90242017
103IRF1_19129219_ChIP-ChIP_H3396_Human0.89281717
104PU.1_20513432_ChIP-Seq_Bcells_Mouse0.89108946
105PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.88713767
106LXR_22292898_ChIP-Seq_THP-1_Human0.88706738
107SPI1_20517297_ChIP-Seq_HL60_Human0.88586813
108KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.88379259
109FOXO3_23340844_ChIP-Seq_DLD1_Human0.88368281
110BCOR_27268052_Chip-Seq_Bcells_Human0.88175324
111MYC_19079543_ChIP-ChIP_MESCs_Mouse0.87745539
112CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.86895375
113POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.86031306
114VDR_23849224_ChIP-Seq_CD4+_Human0.84570704
115SA1_27219007_Chip-Seq_ERYTHROID_Human0.84569538
116PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.83447598
117SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.82065052
118VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.81741119
119Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.81654775
120GATA3_26560356_Chip-Seq_TH1_Human0.81016171
121* SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.80718951
122GATA2_22383799_ChIP-Seq_G1ME_Mouse0.80328905
123SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.80198978
124TCF3_18692474_ChIP-Seq_MEFs_Mouse0.80038937
125GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.79147002
126* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.78054250
127GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.77328229
128TCF3_18692474_ChIP-Seq_MESCs_Mouse0.77259499
129SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human0.77230825
130SA1_27219007_Chip-Seq_Bcells_Human0.77211468
131NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.76979226
132TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.76674035
133CTCF_21964334_Chip-Seq_Bcells_Human0.75250374
134CTCF_27219007_Chip-Seq_ERYTHROID_Human0.72425334
135ZFP281_27345836_Chip-Seq_ESCs_Mouse0.72014846
136SRY_22984422_ChIP-ChIP_TESTIS_Rat0.71765769
137* RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.70886570

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to5.04739811
2MP0003763_abnormal_thymus_physiology4.64245585
3MP0000685_abnormal_immune_system3.51943266
4* MP0006082_CNS_inflammation3.16426258
5MP0001835_abnormal_antigen_presentation3.11583185
6* MP0001800_abnormal_humoral_immune3.09808719
7MP0009785_altered_susceptibility_to2.80194697
8MP0001790_abnormal_immune_system2.77917644
9MP0005387_immune_system_phenotype2.77917644
10* MP0002420_abnormal_adaptive_immunity2.63048613
11* MP0001819_abnormal_immune_cell2.59196914
12* MP0005000_abnormal_immune_tolerance2.58814164
13* MP0002723_abnormal_immune_serum2.57911833
14* MP0002398_abnormal_bone_marrow2.54614366
15* MP0002405_respiratory_system_inflammati2.52700986
16MP0002396_abnormal_hematopoietic_system2.50601079
17MP0009333_abnormal_splenocyte_physiolog2.46615801
18MP0000703_abnormal_thymus_morphology2.32293175
19* MP0005025_abnormal_response_to2.31950304
20MP0002254_reproductive_system_inflammat2.29281806
21* MP0002452_abnormal_antigen_presenting2.25949880
22* MP0000716_abnormal_immune_system2.25487328
23MP0003436_decreased_susceptibility_to2.22212560
24MP0002722_abnormal_immune_system2.20660616
25MP0003448_altered_tumor_morphology2.09622239
26MP0003690_abnormal_glial_cell2.08017741
27MP0000689_abnormal_spleen_morphology2.05428668
28MP0005075_abnormal_melanosome_morpholog2.02715531
29MP0003300_gastrointestinal_ulcer2.00854499
30MP0008057_abnormal_DNA_replication1.96535809
31MP0004264_abnormal_extraembryonic_tissu1.94131219
32MP0004947_skin_inflammation1.89420207
33* MP0002429_abnormal_blood_cell1.88654986
34MP0001873_stomach_inflammation1.88392519
35MP0010352_gastrointestinal_tract_polyps1.85274672
36MP0002166_altered_tumor_susceptibility1.74601224
37MP0002006_tumorigenesis1.71316192
38* MP0010155_abnormal_intestine_physiology1.68384169
39MP0004957_abnormal_blastocyst_morpholog1.67265398
40* MP0000858_altered_metastatic_potential1.62455445
41MP0003866_abnormal_defecation1.59246015
42MP0004883_abnormal_blood_vessel1.56846074
43MP0008961_abnormal_basal_metabolism1.52336213
44MP0003011_delayed_dark_adaptation1.49343242
45MP0003045_fibrosis1.48332988
46* MP0001845_abnormal_inflammatory_respons1.42982042
47MP0005310_abnormal_salivary_gland1.42179222
48MP0002148_abnormal_hypersensitivity_rea1.38062143
49MP0003890_abnormal_embryonic-extraembry1.36757221
50MP0000490_abnormal_crypts_of1.33282803
51MP0002419_abnormal_innate_immunity1.32840819
52MP0002933_joint_inflammation1.32088778
53MP0001663_abnormal_digestive_system1.29434232
54MP0004381_abnormal_hair_follicle1.27393468
55* MP0002019_abnormal_tumor_incidence1.22563292
56MP0003828_pulmonary_edema1.20858934
57MP0003724_increased_susceptibility_to1.20170037
58MP0001853_heart_inflammation1.17959678
59MP0001851_eye_inflammation1.17747260
60MP0005499_abnormal_olfactory_system1.16876346
61MP0005394_taste/olfaction_phenotype1.16876346
62MP0003077_abnormal_cell_cycle1.06689281
63MP0004510_myositis1.04459854
64MP0009764_decreased_sensitivity_to0.99045894
65MP0004808_abnormal_hematopoietic_stem0.98626316
66MP0001348_abnormal_lacrimal_gland0.96874554
67MP0005464_abnormal_platelet_physiology0.96581928
68MP0006292_abnormal_olfactory_placode0.94196189
69MP0005164_abnormal_response_to0.93775000
70MP0002998_abnormal_bone_remodeling0.91870691
71MP0005023_abnormal_wound_healing0.87443278
72MP0003183_abnormal_peptide_metabolism0.86858061
73MP0005167_abnormal_blood-brain_barrier0.86746845
74MP0000350_abnormal_cell_proliferation0.85938630
75MP0000920_abnormal_myelination0.85255220
76MP0004858_abnormal_nervous_system0.85162006
77MP0005408_hypopigmentation0.84119214
78MP0001986_abnormal_taste_sensitivity0.83800272
79* MP0008469_abnormal_protein_level0.82658569
80MP0002086_abnormal_extraembryonic_tissu0.80486879
81MP0002332_abnormal_exercise_endurance0.78766601
82MP0001533_abnormal_skeleton_physiology0.77712095
83MP0005381_digestive/alimentary_phenotyp0.77401701
84MP0005380_embryogenesis_phenotype0.77271936
85MP0001672_abnormal_embryogenesis/_devel0.77271936
86MP0002693_abnormal_pancreas_physiology0.76683011
87MP0002277_abnormal_respiratory_mucosa0.76497043
88MP0002088_abnormal_embryonic_growth/wei0.75712405
89MP0008007_abnormal_cellular_replicative0.74756452
90MP0002138_abnormal_hepatobiliary_system0.72763782
91MP0003984_embryonic_growth_retardation0.72327628
92MP0002127_abnormal_cardiovascular_syste0.72167388
93MP0003705_abnormal_hypodermis_morpholog0.71367840
94MP0000249_abnormal_blood_vessel0.69649412
95MP0009763_increased_sensitivity_to0.68259788
96MP0003121_genomic_imprinting0.67907823
97MP0000609_abnormal_liver_physiology0.67904810
98MP0005647_abnormal_sex_gland0.67877156
99MP0000313_abnormal_cell_death0.67522371
100MP0009278_abnormal_bone_marrow0.66943101
101MP0003693_abnormal_embryo_hatching0.66921701
102MP0003172_abnormal_lysosome_physiology0.65904896
103MP0003453_abnormal_keratinocyte_physiol0.65722865
104MP0010094_abnormal_chromosome_stability0.65185050
105MP0000613_abnormal_salivary_gland0.65113285
106MP0000465_gastrointestinal_hemorrhage0.62780345
107* MP0002132_abnormal_respiratory_system0.61299129
108MP0008770_decreased_survivor_rate0.61189048
109MP0010307_abnormal_tumor_latency0.60333704
110MP0008874_decreased_physiological_sensi0.60149922
111MP0005451_abnormal_body_composition0.59355922
112MP0001243_abnormal_dermal_layer0.58752694
113MP0005166_decreased_susceptibility_to0.58481160
114MP0001915_intracranial_hemorrhage0.57856377
115MP0005397_hematopoietic_system_phenotyp0.57252144
116MP0001545_abnormal_hematopoietic_system0.57252144
117MP0009765_abnormal_xenobiotic_induced0.56695189
118MP0006035_abnormal_mitochondrial_morpho0.55384336
119MP0000477_abnormal_intestine_morphology0.53762082
120MP0005390_skeleton_phenotype0.53614301
121MP0002970_abnormal_white_adipose0.53430443
122MP0003303_peritoneal_inflammation0.52799200
123MP0003111_abnormal_nucleus_morphology0.52275247
124MP0003191_abnormal_cellular_cholesterol0.51465392
125MP0008873_increased_physiological_sensi0.51305060
126MP0003075_altered_response_to0.50065952
127MP0003252_abnormal_bile_duct0.49870153
128MP0000470_abnormal_stomach_morphology0.48997956
129MP0002163_abnormal_gland_morphology0.44864608
130MP0003795_abnormal_bone_structure0.43888967
131MP0008260_abnormal_autophagy0.43856053
132MP0000569_abnormal_digit_pigmentation0.43061596
133MP0005319_abnormal_enzyme/_coenzyme0.42233895
134MP0002876_abnormal_thyroid_physiology0.41834197
135MP0000604_amyloidosis0.41745389
136MP0001346_abnormal_lacrimal_gland0.40707430

Predicted human phenotypes

RankGene SetZ-score
1T lymphocytopenia (HP:0005403)7.00397527
2Abnormality of T cell number (HP:0011839)6.65531150
3Combined immunodeficiency (HP:0005387)5.39456263
4Abnormality of macrophages (HP:0004311)4.89630518
5Myositis (HP:0100614)4.74564821
6Abnormality of T cells (HP:0002843)4.72723739
7Recurrent bacterial skin infections (HP:0005406)4.70945842
8Elevated erythrocyte sedimentation rate (HP:0003565)4.56482646
9Orchitis (HP:0100796)4.20718697
10Severe combined immunodeficiency (HP:0004430)4.10444545
11Bilateral microphthalmos (HP:0007633)4.09045473
12Recurrent bronchitis (HP:0002837)3.88906310
13Multiple enchondromatosis (HP:0005701)3.78734607
14Recurrent skin infections (HP:0001581)3.75142510
15Autoimmune thrombocytopenia (HP:0001973)3.62066441
16Panhypogammaglobulinemia (HP:0003139)3.52979144
17Optic neuritis (HP:0100653)3.51337864
18Retrobulbar optic neuritis (HP:0100654)3.51337864
19Encephalitis (HP:0002383)3.47481137
20Increased IgM level (HP:0003496)3.41355190
21Abnormal delayed hypersensitivity skin test (HP:0002963)3.39908735
22Stomatitis (HP:0010280)3.37983203
23Hypochromic microcytic anemia (HP:0004840)3.34830554
24Chronic obstructive pulmonary disease (HP:0006510)3.34498922
25Obstructive lung disease (HP:0006536)3.34498922
26Recurrent gram-negative bacterial infections (HP:0005420)3.33738243
27Abnormality of pyrimidine metabolism (HP:0004353)3.21301532
28Rib fusion (HP:0000902)3.19099350
29IgM deficiency (HP:0002850)3.17223249
30Recurrent viral infections (HP:0004429)3.16437368
31Recurrent fungal infections (HP:0002841)3.15676583
32Hemiplegia (HP:0002301)3.14839246
33* Nasal polyposis (HP:0100582)3.08332541
34Joint swelling (HP:0001386)3.04970942
35Abnormality of T cell physiology (HP:0011840)2.95125342
36Chronic otitis media (HP:0000389)2.93979751
37Pulmonary infiltrates (HP:0002113)2.91228215
38Urticaria (HP:0001025)2.87252596
39Stomach cancer (HP:0012126)2.85193718
40Recurrent cutaneous fungal infections (HP:0011370)2.83951469
41Chronic mucocutaneous candidiasis (HP:0002728)2.83951469
42IgG deficiency (HP:0004315)2.81674059
43Hepatoblastoma (HP:0002884)2.71657060
44Zonular cataract (HP:0010920)2.70306283
45Abnormality of B cell number (HP:0010975)2.69390557
46Hypoproteinemia (HP:0003075)2.68752902
47Eczematoid dermatitis (HP:0000976)2.68570114
48Leukocytosis (HP:0001974)2.66131149
49Abnormality of eosinophils (HP:0001879)2.64453877
50Meningitis (HP:0001287)2.64365861
51Thrombocytosis (HP:0001894)2.62976668
52Amyotrophic lateral sclerosis (HP:0007354)2.62575695
53Gingivitis (HP:0000230)2.54868180
54Vasculitis (HP:0002633)2.54120578
55Abnormality of the lower motor neuron (HP:0002366)2.53306433
56Pustule (HP:0200039)2.52947673
57Cheilitis (HP:0100825)2.49924706
58Tetraplegia (HP:0002445)2.49175659
59Hypochromic anemia (HP:0001931)2.48749497
60Keratitis (HP:0000491)2.46882078
61Hemoptysis (HP:0002105)2.44448853
62Chest pain (HP:0100749)2.44319734
63Prolonged bleeding time (HP:0003010)2.40674687
64Ependymoma (HP:0002888)2.37146442
65* Abnormality of the nasal mucosa (HP:0000433)2.37131889
66Gastrointestinal stroma tumor (HP:0100723)2.36995382
67Keratoconjunctivitis sicca (HP:0001097)2.34639341
68Interstitial pulmonary disease (HP:0006530)2.32317998
69Keratoconjunctivitis (HP:0001096)2.31519714
70Thyroiditis (HP:0100646)2.30589528
71Lymphoma (HP:0002665)2.28112584
72Gingival bleeding (HP:0000225)2.27790133
73Bronchitis (HP:0012387)2.24112716
74Inflammation of the large intestine (HP:0002037)2.21823932
75Anomalous pulmonary venous return (HP:0010772)2.21383090
76Abnormality of the pleura (HP:0002103)2.19749039
77Gangrene (HP:0100758)2.17822423
78Eosinophilia (HP:0001880)2.15625710
79Cellulitis (HP:0100658)2.15353777
80Chronic diarrhea (HP:0002028)2.14534783
81Epistaxis (HP:0000421)2.14329412
82Arterial thrombosis (HP:0004420)2.10360119
83Dislocated radial head (HP:0003083)2.09760306
84Intestinal fistula (HP:0100819)2.09495186
85Gastrointestinal inflammation (HP:0004386)2.09440060
86Neoplasm of striated muscle (HP:0009728)2.09270527
87Gastrointestinal infarctions (HP:0005244)2.07896972
88Abnormality of iron homeostasis (HP:0011031)2.05713076
89Abnormality of the fingertips (HP:0001211)2.05284679
90Recurrent sinusitis (HP:0011108)2.04745577
91Increased IgE level (HP:0003212)2.04631007
92Abnormality of monocarboxylic acid metabolism (HP:0010996)2.04380619
93Lymphopenia (HP:0001888)2.03700269
94Rhabdomyosarcoma (HP:0002859)2.03338810
95Oral leukoplakia (HP:0002745)2.02560288
96Increased CSF protein (HP:0002922)2.02503320
97Preauricular skin tag (HP:0000384)2.01511429
98Abnormality of the prostate (HP:0008775)1.99924461
99Abnormal albumin level (HP:0012116)1.99687224
100Hypoalbuminemia (HP:0003073)1.99687224
101Abnormality of cells of the lymphoid lineage (HP:0012140)1.99686117
102Leukopenia (HP:0001882)1.99191742
103Skin tags (HP:0010609)1.97825757
104Sepsis (HP:0100806)1.96644020
105Episodic fever (HP:0001954)1.96615635
106Skin ulcer (HP:0200042)1.95700572
107Emphysema (HP:0002097)1.95207877
108Anorexia (HP:0002039)1.95088682
109Flat occiput (HP:0005469)1.94778939
110Abnormality of the radial head (HP:0003995)1.93648597
111Polyneuropathy (HP:0001271)1.93264834
112Abnormality of small intestinal villus morphology (HP:0011472)1.92207816
113Villous atrophy (HP:0011473)1.92207816
114Abnormality of oral frenula (HP:0000190)1.92088447
115Papilloma (HP:0012740)1.91786857
116Verrucae (HP:0200043)1.91786857
117Neoplasm of the tracheobronchial system (HP:0100552)1.89990514
118IgA deficiency (HP:0002720)1.89852474
119Spontaneous hematomas (HP:0007420)1.89147145
120Glomerulopathy (HP:0100820)1.88629267
121Amaurosis fugax (HP:0100576)1.88310179
122Aplasia/Hypoplasia of the thymus (HP:0010515)1.86933677
123Large earlobe (HP:0009748)1.86902414
124Autoimmune hemolytic anemia (HP:0001890)1.86067062
125Agammaglobulinemia (HP:0004432)1.84990647
126Increased serum ferritin (HP:0003281)1.84794969
127Rectal fistula (HP:0100590)1.83636488
128Rectovaginal fistula (HP:0000143)1.83636488
129Abnormality of the pulmonary veins (HP:0011718)1.82987664
130Hypergammaglobulinemia (HP:0010702)1.80895766
131Prominent nose (HP:0000448)1.80644744
132Ragged-red muscle fibers (HP:0003200)1.80614748
133Reduced antithrombin III activity (HP:0001976)1.78589625
134Granulocytopenia (HP:0001913)1.77090736
135Pulmonary embolism (HP:0002204)1.76870096
136Recurrent abscess formation (HP:0002722)1.76054889
137Mediastinal lymphadenopathy (HP:0100721)1.74167937
138Colitis (HP:0002583)1.72829510

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK124.94985313
2MAP4K14.44442631
3TXK4.43016855
4GRK64.23582312
5RIPK43.55307439
6STK103.36348375
7JAK32.59937944
8ERN12.52964544
9GRK52.51943373
10PASK2.50573870
11CSK2.50090250
12ADRBK22.37533856
13PRPF4B2.25002161
14ZAP702.23836297
15JAK12.13771740
16TYRO32.11548460
17TAOK32.09524037
18FGFR32.08832677
19GRK72.05035788
20* ITK1.99186497
21TGFBR21.93438352
22MAP3K101.89883747
23CSF1R1.89694932
24TYK21.81407326
25FGFR41.80414504
26PTK2B1.76603215
27FGR1.71758928
28MAP2K31.53163745
29LCK1.51735749
30MAPK71.48841663
31GRK11.42285173
32MST41.39341374
33MAP3K141.38978059
34MAP2K61.33727844
35MAP3K111.32548035
36IKBKE1.31512143
37IKBKB1.25750233
38BLK1.23933735
39CAMKK11.23038619
40MAP3K71.17309665
41PRKCH1.10765371
42ALK1.09432278
43MAP3K31.08473059
44PRKCQ1.06635376
45MAP3K121.05863417
46MARK21.05285195
47HCK1.03312134
48HIPK20.95981148
49SYK0.94830183
50NLK0.93704446
51TEC0.91946451
52MELK0.90046637
53BTK0.89273870
54TBK10.87690809
55CDK40.85092066
56TRIB30.85030554
57WNK10.84549973
58PRKG20.84080860
59TAOK20.83021223
60TESK20.82621693
61SIK20.80953719
62KDR0.78286753
63PIM10.78092193
64TAOK10.75800614
65MOS0.75368018
66EEF2K0.74743551
67BMPR20.72676414
68CHUK0.72569521
69EPHA30.70039904
70EPHB10.69866457
71JAK20.67295936
72LRRK20.64776991
73MARK30.64493838
74RPS6KA40.62360430
75TNK20.59467996
76CAMK40.58107487
77DMPK0.56409806
78CDK70.55887512
79MAP3K10.54139970
80MATK0.53617514
81CLK10.53116997
82FES0.51996120
83CDK90.50792988
84MAP3K50.50094287
85INSR0.49999395
86KIT0.49874647
87PAK40.49585698
88IGF1R0.49560892
89PRKD20.48286190
90MAP3K130.47846667
91PTK60.47677288
92PDPK10.47292435
93LYN0.44696910
94NEK20.43203114
95TSSK60.42947313
96MAPK120.42335615
97CHEK10.38681380
98TTK0.38285458
99SMG10.38056917
100PRKCZ0.37049828
101STK380.36877828
102PDK10.35736455
103YES10.34593626
104TTN0.34058309
105ADRBK10.33971292
106PDGFRB0.30569556
107BRD40.28793535
108PKN10.28371132
109IRAK40.27592943
110PIK3CG0.27506264
111CDC42BPA0.26871871
112MAP3K80.26621132
113NME20.25926539
114SIK30.25103468
115PRKCD0.23884773
116MTOR0.23587631
117PRKAA20.22524805
118SIK10.21783409
119FGFR10.19825558
120MAPK30.19760743
121IRAK10.19664744
122RIPK10.19222654
123MAPK110.19204884
124FYN0.18625108
125KSR20.18367820
126CAMKK20.17539111
127ABL10.17519489
128CDK20.17113428
129MAPKAPK20.16294080

Predicted pathways (KEGG)

RankGene SetZ-score
1Graft-versus-host disease_Homo sapiens_hsa053324.97211049
2Primary immunodeficiency_Homo sapiens_hsa053404.72646701
3Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046503.83883768
4T cell receptor signaling pathway_Homo sapiens_hsa046603.53795815
5Allograft rejection_Homo sapiens_hsa053303.17894471
6Antigen processing and presentation_Homo sapiens_hsa046122.96872832
7* Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.79023542
8Intestinal immune network for IgA production_Homo sapiens_hsa046722.34698102
9NF-kappa B signaling pathway_Homo sapiens_hsa040642.30303897
10Measles_Homo sapiens_hsa051622.23311649
11Autoimmune thyroid disease_Homo sapiens_hsa053202.18489609
12Type I diabetes mellitus_Homo sapiens_hsa049402.05456244
13Viral myocarditis_Homo sapiens_hsa054161.86175203
14B cell receptor signaling pathway_Homo sapiens_hsa046621.79733830
15Jak-STAT signaling pathway_Homo sapiens_hsa046301.77915317
16Leishmaniasis_Homo sapiens_hsa051401.69577129
17Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.54492835
18Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.50506621
19RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.50453213
20Hematopoietic cell lineage_Homo sapiens_hsa046401.47906592
21Osteoclast differentiation_Homo sapiens_hsa043801.46594613
22Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.46522307
23Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.45442901
24Herpes simplex infection_Homo sapiens_hsa051681.43645612
25Leukocyte transendothelial migration_Homo sapiens_hsa046701.31493727
26Rheumatoid arthritis_Homo sapiens_hsa053231.26530584
27Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.25243555
28Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.25143477
29Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.24134572
30Apoptosis_Homo sapiens_hsa042101.24090636
31Vitamin B6 metabolism_Homo sapiens_hsa007501.22065646
32Chemokine signaling pathway_Homo sapiens_hsa040621.19008853
33Acute myeloid leukemia_Homo sapiens_hsa052211.18863120
34Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.16575294
35Toxoplasmosis_Homo sapiens_hsa051451.16463798
36TNF signaling pathway_Homo sapiens_hsa046681.14664300
37Pancreatic cancer_Homo sapiens_hsa052121.12080916
38Malaria_Homo sapiens_hsa051441.09601226
39HTLV-I infection_Homo sapiens_hsa051661.06254311
40VEGF signaling pathway_Homo sapiens_hsa043701.00861104
41Hepatitis B_Homo sapiens_hsa051610.95237546
42NOD-like receptor signaling pathway_Homo sapiens_hsa046210.90823983
43Influenza A_Homo sapiens_hsa051640.90544868
44Transcriptional misregulation in cancer_Homo sapiens_hsa052020.84411356
45Regulation of actin cytoskeleton_Homo sapiens_hsa048100.83931281
46Shigellosis_Homo sapiens_hsa051310.80017889
47Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.79652764
48mTOR signaling pathway_Homo sapiens_hsa041500.77464663
49Colorectal cancer_Homo sapiens_hsa052100.73317981
50Phagosome_Homo sapiens_hsa041450.72394514
51Toll-like receptor signaling pathway_Homo sapiens_hsa046200.68570418
52Epstein-Barr virus infection_Homo sapiens_hsa051690.68567276
53Drug metabolism - other enzymes_Homo sapiens_hsa009830.67065373
54Chronic myeloid leukemia_Homo sapiens_hsa052200.66248206
55Legionellosis_Homo sapiens_hsa051340.66023339
56Viral carcinogenesis_Homo sapiens_hsa052030.63160405
57Non-small cell lung cancer_Homo sapiens_hsa052230.63137387
58Thyroid cancer_Homo sapiens_hsa052160.62218042
59Hepatitis C_Homo sapiens_hsa051600.62052093
60p53 signaling pathway_Homo sapiens_hsa041150.61611483
61Ribosome_Homo sapiens_hsa030100.59433654
62Prolactin signaling pathway_Homo sapiens_hsa049170.58504759
63AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.56606540
64Platelet activation_Homo sapiens_hsa046110.55795053
65Neurotrophin signaling pathway_Homo sapiens_hsa047220.55173344
66Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.54291612
67Staphylococcus aureus infection_Homo sapiens_hsa051500.53175512
68RNA degradation_Homo sapiens_hsa030180.52009292
69Fructose and mannose metabolism_Homo sapiens_hsa000510.51810901
70Tuberculosis_Homo sapiens_hsa051520.50699150
71Systemic lupus erythematosus_Homo sapiens_hsa053220.50515017
72Inositol phosphate metabolism_Homo sapiens_hsa005620.50492422
73FoxO signaling pathway_Homo sapiens_hsa040680.50339447
74Small cell lung cancer_Homo sapiens_hsa052220.49913347
75Rap1 signaling pathway_Homo sapiens_hsa040150.47920364
76Sphingolipid signaling pathway_Homo sapiens_hsa040710.45934584
77Phosphatidylinositol signaling system_Homo sapiens_hsa040700.44838851
78Asthma_Homo sapiens_hsa053100.44509521
79RNA transport_Homo sapiens_hsa030130.44363849
80mRNA surveillance pathway_Homo sapiens_hsa030150.43866394
81MAPK signaling pathway_Homo sapiens_hsa040100.43523019
82Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.43297464
83Spliceosome_Homo sapiens_hsa030400.43267360
84Notch signaling pathway_Homo sapiens_hsa043300.41211198
85Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.40478928
86Phospholipase D signaling pathway_Homo sapiens_hsa040720.38762686
87Thyroid hormone signaling pathway_Homo sapiens_hsa049190.38697873
88Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.38080789
89Carbohydrate digestion and absorption_Homo sapiens_hsa049730.37532826
90Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.37338277
91Endocytosis_Homo sapiens_hsa041440.37172989
92Choline metabolism in cancer_Homo sapiens_hsa052310.36946590
93Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.36333178
94Pathways in cancer_Homo sapiens_hsa052000.34657471
95MicroRNAs in cancer_Homo sapiens_hsa052060.32716828
96Salmonella infection_Homo sapiens_hsa051320.32205294
97Pertussis_Homo sapiens_hsa051330.32181674
98Dorso-ventral axis formation_Homo sapiens_hsa043200.31897224
99Lysosome_Homo sapiens_hsa041420.31408783
100Non-homologous end-joining_Homo sapiens_hsa034500.31359168
101African trypanosomiasis_Homo sapiens_hsa051430.30003781
102Type II diabetes mellitus_Homo sapiens_hsa049300.29917835
103DNA replication_Homo sapiens_hsa030300.28723451
104Cell cycle_Homo sapiens_hsa041100.27504567
105GnRH signaling pathway_Homo sapiens_hsa049120.26583796
106HIF-1 signaling pathway_Homo sapiens_hsa040660.26180359
107Fanconi anemia pathway_Homo sapiens_hsa034600.25383654
108Ras signaling pathway_Homo sapiens_hsa040140.23494985
109Adipocytokine signaling pathway_Homo sapiens_hsa049200.23363506
110Renal cell carcinoma_Homo sapiens_hsa052110.23311137
111Proteoglycans in cancer_Homo sapiens_hsa052050.22657258
112Insulin resistance_Homo sapiens_hsa049310.21775352
113Adherens junction_Homo sapiens_hsa045200.21543139
114Galactose metabolism_Homo sapiens_hsa000520.20822051
115Regulation of autophagy_Homo sapiens_hsa041400.20655354
116Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.19650749
117Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.18225425
118Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.17274730
119Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.16736224
120Other glycan degradation_Homo sapiens_hsa005110.14051515
121Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.11668400
122Oxytocin signaling pathway_Homo sapiens_hsa049210.10841546
123Endometrial cancer_Homo sapiens_hsa052130.08875393
124Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.08655644
125Amoebiasis_Homo sapiens_hsa051460.07407780

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