TBP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes TBP, the TATA-binding protein. A distinctive feature of TBP is a long string of glutamines in the N-terminus. This region of the protein modulates the DNA binding activity of the C terminus, and modulation of DNA binding affects the rate of transcription complex formation and initiation of transcription. The number of CAG repeats encoding the polyglutamine tract is usually 25-42, and expansion of the number of repeats to 45-66 increases the length of the polyglutamine string and is associated with spinocerebellar ataxia 17, a neurodegenerative disorder classified as a polyglutamine disease. Two transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1proteasome assembly (GO:0043248)4.93452399
2CENP-A containing nucleosome assembly (GO:0034080)4.27853029
3chromatin remodeling at centromere (GO:0031055)4.19982089
4DNA double-strand break processing (GO:0000729)4.11980554
5DNA replication checkpoint (GO:0000076)3.99560967
6respiratory chain complex IV assembly (GO:0008535)3.98820304
7mitotic metaphase plate congression (GO:0007080)3.96665879
8DNA replication-independent nucleosome assembly (GO:0006336)3.85483921
9DNA replication-independent nucleosome organization (GO:0034724)3.85483921
10ribosome assembly (GO:0042255)3.83476735
11DNA strand elongation involved in DNA replication (GO:0006271)3.82986523
12nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.82421483
13kinetochore organization (GO:0051383)3.81952255
14protein complex biogenesis (GO:0070271)3.81774979
15mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.81142886
16mitochondrial respiratory chain complex I assembly (GO:0032981)3.81142886
17NADH dehydrogenase complex assembly (GO:0010257)3.81142886
18DNA replication initiation (GO:0006270)3.79494089
19telomere maintenance via semi-conservative replication (GO:0032201)3.76818999
20mitochondrial respiratory chain complex assembly (GO:0033108)3.74552268
21meiotic chromosome segregation (GO:0045132)3.73752207
22negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.73086105
23DNA strand elongation (GO:0022616)3.70279202
24DNA deamination (GO:0045006)3.68430576
25regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.66528785
26histone exchange (GO:0043486)3.66442911
27cullin deneddylation (GO:0010388)3.61282706
28positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.59555332
29replication fork processing (GO:0031297)3.59473326
30kinetochore assembly (GO:0051382)3.57027134
31chaperone-mediated protein transport (GO:0072321)3.56742334
32cytochrome complex assembly (GO:0017004)3.55754079
33telomere maintenance via recombination (GO:0000722)3.53970405
34RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.53948103
35nuclear pore organization (GO:0006999)3.52066754
36nuclear pore complex assembly (GO:0051292)3.51067744
37protein deneddylation (GO:0000338)3.49709212
38metaphase plate congression (GO:0051310)3.47358977
39piRNA metabolic process (GO:0034587)3.46400000
40attachment of spindle microtubules to kinetochore (GO:0008608)3.46166357
41anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.46072290
42mitotic recombination (GO:0006312)3.45758333
43regulation of nuclear cell cycle DNA replication (GO:0033262)3.45559767
44DNA damage response, detection of DNA damage (GO:0042769)3.41472299
45DNA catabolic process, exonucleolytic (GO:0000738)3.41059424
46transcription from mitochondrial promoter (GO:0006390)3.39228436
47establishment of protein localization to mitochondrial membrane (GO:0090151)3.36353271
48negative regulation of ligase activity (GO:0051352)3.36306826
49negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.36306826
50maturation of SSU-rRNA (GO:0030490)3.33768813
51histone mRNA metabolic process (GO:0008334)3.31928588
52mitotic sister chromatid cohesion (GO:0007064)3.31425281
53pseudouridine synthesis (GO:0001522)3.27668152
54mitochondrial RNA metabolic process (GO:0000959)3.22696981
55peptidyl-histidine modification (GO:0018202)3.20301215
56regulation of cellular amino acid metabolic process (GO:0006521)3.19102449
57histone H2A acetylation (GO:0043968)3.17970930
58positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.16844535
59DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.15754256
60mitotic nuclear envelope disassembly (GO:0007077)3.15269854
61signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.15071175
62signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.15071175
63signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.15071175
64telomere maintenance via telomere lengthening (GO:0010833)3.12924228
65ribosomal small subunit assembly (GO:0000028)3.12767636
66water-soluble vitamin biosynthetic process (GO:0042364)3.12125876
67regulation of mitochondrial translation (GO:0070129)3.11780940
68mismatch repair (GO:0006298)3.10013775
69signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.09467457
70intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.09467457
71regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.07961773
72establishment of viral latency (GO:0019043)3.07836153
73cilium or flagellum-dependent cell motility (GO:0001539)3.07386493
74DNA replication-dependent nucleosome assembly (GO:0006335)3.06614895
75DNA replication-dependent nucleosome organization (GO:0034723)3.06614895
76somatic hypermutation of immunoglobulin genes (GO:0016446)3.06508611
77somatic diversification of immune receptors via somatic mutation (GO:0002566)3.06508611
78protein localization to chromosome, centromeric region (GO:0071459)3.05220495
79somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.05105005
80isotype switching (GO:0045190)3.05105005
81somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.05105005
82positive regulation of ligase activity (GO:0051351)3.04295646
83signal transduction involved in DNA damage checkpoint (GO:0072422)3.03720953
84signal transduction involved in DNA integrity checkpoint (GO:0072401)3.03720953
85signal transduction involved in cell cycle checkpoint (GO:0072395)3.03714637
86rRNA modification (GO:0000154)3.03587435
87nucleotide-excision repair, DNA gap filling (GO:0006297)3.03576043
88intra-S DNA damage checkpoint (GO:0031573)3.03550911
89pore complex assembly (GO:0046931)3.02842097
90mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.02263610
91microtubule depolymerization (GO:0007019)3.01821031
92establishment of chromosome localization (GO:0051303)3.01797593
93centriole assembly (GO:0098534)3.00813242
94maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.00556370
95protein K6-linked ubiquitination (GO:0085020)2.99964551
96L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.99788980
97regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.99640024
98regulation of mitotic spindle checkpoint (GO:1903504)2.99640024
99protein targeting to mitochondrion (GO:0006626)2.98324745
100protein localization to kinetochore (GO:0034501)2.98110140
101tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.97840578
102RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.97840578
103postreplication repair (GO:0006301)2.96501974
104rRNA methylation (GO:0031167)2.93586589
105ribosome biogenesis (GO:0042254)2.93246702
106transcription elongation from RNA polymerase III promoter (GO:0006385)2.92897256
107termination of RNA polymerase III transcription (GO:0006386)2.92897256
108transcription-coupled nucleotide-excision repair (GO:0006283)2.92858381
109deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.92245287
110membrane disassembly (GO:0030397)2.90624789
111nuclear envelope disassembly (GO:0051081)2.90624789
112DNA unwinding involved in DNA replication (GO:0006268)2.90495738
113ribosomal large subunit biogenesis (GO:0042273)2.90474286
114mannosylation (GO:0097502)2.90454027
115negative regulation of DNA recombination (GO:0045910)2.90174998
116rRNA processing (GO:0006364)2.89364441
117spindle checkpoint (GO:0031577)2.88855778
118regulation of centriole replication (GO:0046599)2.88585292
119regulation of ubiquitin-protein transferase activity (GO:0051438)2.88473293
120negative regulation of DNA-dependent DNA replication (GO:2000104)2.86842261
121centriole replication (GO:0007099)2.86665643
122negative regulation of mRNA processing (GO:0050686)2.86620055
123negative regulation of mitotic sister chromatid separation (GO:2000816)2.86573065
124negative regulation of mitotic sister chromatid segregation (GO:0033048)2.86573065
125negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.86573065
126negative regulation of sister chromatid segregation (GO:0033046)2.86573065
127DNA methylation involved in gamete generation (GO:0043046)2.83471062
128spindle assembly checkpoint (GO:0071173)2.83340303
129chromatin assembly or disassembly (GO:0006333)2.82558523
1307-methylguanosine mRNA capping (GO:0006370)2.82232155
131ribonucleoprotein complex biogenesis (GO:0022613)2.82197974
132rRNA metabolic process (GO:0016072)2.81449000
133negative regulation of chromosome segregation (GO:0051985)2.81379742
1347-methylguanosine RNA capping (GO:0009452)2.81098586
135RNA capping (GO:0036260)2.81098586
136negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.81022416
137exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.80928175
138pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.80923321
139regulation of mitotic metaphase/anaphase transition (GO:0030071)2.79871801
140inner mitochondrial membrane organization (GO:0007007)2.79681843
141spliceosomal snRNP assembly (GO:0000387)2.79471458
142regulation of ligase activity (GO:0051340)2.79126632
143DNA ligation (GO:0006266)2.78762742
144maturation of 5.8S rRNA (GO:0000460)2.77912584
145reciprocal meiotic recombination (GO:0007131)2.77411354
146reciprocal DNA recombination (GO:0035825)2.77411354
147sister chromatid cohesion (GO:0007062)2.77254985
148ATP-dependent chromatin remodeling (GO:0043044)2.77129707
149protein localization to mitochondrion (GO:0070585)2.76245505
150mitotic spindle assembly checkpoint (GO:0007094)2.76183857
151regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.75734965
152regulation of chromosome segregation (GO:0051983)2.75374909
153* transcription elongation from RNA polymerase I promoter (GO:0006362)2.75321413
154spliceosomal complex assembly (GO:0000245)2.74977193
155mitotic spindle checkpoint (GO:0071174)2.74436384
156recombinational repair (GO:0000725)2.73949892
157DNA synthesis involved in DNA repair (GO:0000731)2.73942902
158establishment of protein localization to mitochondrion (GO:0072655)2.73284059
159nucleobase biosynthetic process (GO:0046112)2.73072885
160regulation of helicase activity (GO:0051095)2.73002103
161regulation of spindle organization (GO:0090224)2.72233635
162termination of RNA polymerase II transcription (GO:0006369)2.72194750
163* termination of RNA polymerase I transcription (GO:0006363)2.71843833
164establishment of integrated proviral latency (GO:0075713)2.71778317
165purine nucleobase biosynthetic process (GO:0009113)2.70770782
166regulation of mitotic sister chromatid separation (GO:0010965)2.70565736
167regulation of mitotic sister chromatid segregation (GO:0033047)2.70565736
168regulation of sister chromatid segregation (GO:0033045)2.70565736
169mitotic sister chromatid segregation (GO:0000070)2.70407448
170telomere maintenance (GO:0000723)2.69674613
171telomere organization (GO:0032200)2.68703760

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.42334454
2E2F4_17652178_ChIP-ChIP_JURKAT_Human4.06567420
3MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse3.53717440
4* KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.50954739
5FOXM1_23109430_ChIP-Seq_U2OS_Human3.49466824
6MYC_18555785_ChIP-Seq_MESCs_Mouse3.48041617
7FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.17030293
8EST1_17652178_ChIP-ChIP_JURKAT_Human3.01408805
9* GABP_17652178_ChIP-ChIP_JURKAT_Human2.97374660
10* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.80461010
11* ETS1_20019798_ChIP-Seq_JURKAT_Human2.59423347
12MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.55204586
13ZNF274_21170338_ChIP-Seq_K562_Hela2.52766069
14CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.51679012
15* VDR_23849224_ChIP-Seq_CD4+_Human2.50785029
16E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.49961059
17* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.36931614
18HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.35256443
19* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.34245164
20CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.33178381
21ELF1_17652178_ChIP-ChIP_JURKAT_Human2.30432447
22MYC_19079543_ChIP-ChIP_MESCs_Mouse2.25426520
23* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.24542319
24* FOXP3_21729870_ChIP-Seq_TREG_Human2.08014699
25* CREB1_15753290_ChIP-ChIP_HEK293T_Human2.04940636
26XRN2_22483619_ChIP-Seq_HELA_Human2.02480436
27MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.00201413
28EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.97193106
29* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.96173770
30FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.93781659
31E2F1_21310950_ChIP-Seq_MCF-7_Human1.91749801
32NELFA_20434984_ChIP-Seq_ESCs_Mouse1.90997673
33YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.89857639
34SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.84737477
35* ELK1_19687146_ChIP-ChIP_HELA_Human1.83295772
36TP63_19390658_ChIP-ChIP_HaCaT_Human1.82661866
37SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.79509913
38THAP11_20581084_ChIP-Seq_MESCs_Mouse1.75114301
39DCP1A_22483619_ChIP-Seq_HELA_Human1.74792761
40PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.73414205
41AR_21909140_ChIP-Seq_LNCAP_Human1.73345262
42NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.71558833
43* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.70503368
44* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.69698815
45* TTF2_22483619_ChIP-Seq_HELA_Human1.66389959
46NOTCH1_21737748_ChIP-Seq_TLL_Human1.64386744
47HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.63915237
48SRF_21415370_ChIP-Seq_HL-1_Mouse1.60871732
49* GABP_19822575_ChIP-Seq_HepG2_Human1.57449879
50E2F1_18555785_ChIP-Seq_MESCs_Mouse1.51664469
51POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.49365542
52SALL1_21062744_ChIP-ChIP_HESCs_Human1.45943342
53YY1_21170310_ChIP-Seq_MESCs_Mouse1.45351750
54* CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.45121521
55VDR_22108803_ChIP-Seq_LS180_Human1.44587400
56SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.43961048
57CIITA_25753668_ChIP-Seq_RAJI_Human1.43739372
58RBPJ_22232070_ChIP-Seq_NCS_Mouse1.43644058
59* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.42070775
60IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.41298634
61* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.40602489
62ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.40574599
63* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.37774892
64* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.35247750
65POU3F2_20337985_ChIP-ChIP_501MEL_Human1.30676661
66PADI4_21655091_ChIP-ChIP_MCF-7_Human1.30406135
67FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.24007914
68FLI1_27457419_Chip-Seq_LIVER_Mouse1.22709428
69ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.21665840
70MYC_18940864_ChIP-ChIP_HL60_Human1.18663173
71KDM5A_27292631_Chip-Seq_BREAST_Human1.17250704
72IGF1R_20145208_ChIP-Seq_DFB_Human1.14718737
73PCGF2_27294783_Chip-Seq_ESCs_Mouse1.13012719
74IRF1_19129219_ChIP-ChIP_H3396_Human1.09440113
75* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.09399133
76E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.08666419
77NANOG_18555785_ChIP-Seq_MESCs_Mouse1.07759945
78* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.07357074
79SPI1_23547873_ChIP-Seq_NB4_Human1.04662758
80ZFX_18555785_ChIP-Seq_MESCs_Mouse1.04303164
81FUS_26573619_Chip-Seq_HEK293_Human1.03363063
82TP53_22573176_ChIP-Seq_HFKS_Human1.02413542
83POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.01999142
84* PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.01636399
85EWS_26573619_Chip-Seq_HEK293_Human1.00510455
86* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.98990757
87* CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.95294058
88GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95248091
89* PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.94410209
90ELK1_22589737_ChIP-Seq_MCF10A_Human0.92268174
91EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.92230680
92IRF8_21731497_ChIP-ChIP_J774_Mouse0.91399469
93TAF15_26573619_Chip-Seq_HEK293_Human0.91127920
94FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.91005585
95* SOX2_16153702_ChIP-ChIP_HESCs_Human0.90529383
96* NANOG_16153702_ChIP-ChIP_HESCs_Human0.89924238
97MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.86893827
98P300_19829295_ChIP-Seq_ESCs_Human0.86455218
99ZFP57_27257070_Chip-Seq_ESCs_Mouse0.85678981
100TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.85547063
101EGR1_19374776_ChIP-ChIP_THP-1_Human0.85436131
102KAP1_22055183_ChIP-Seq_ESCs_Mouse0.84116328
103* HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.82163306
104GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.81405676
105GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.80421255
106CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.80017266
107NFE2_27457419_Chip-Seq_LIVER_Mouse0.77668310
108SOX2_18555785_ChIP-Seq_MESCs_Mouse0.77487424
109* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.75666737
110DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.72297812
111POU5F1_16153702_ChIP-ChIP_HESCs_Human0.72259592
112SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.71654979
113PCGF2_27294783_Chip-Seq_NPCs_Mouse0.70001357
114CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.69963283
115MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.69746021
116GATA1_26923725_Chip-Seq_HPCs_Mouse0.69702141
117SUZ12_27294783_Chip-Seq_NPCs_Mouse0.68762348
118* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.67934567
119TFEB_21752829_ChIP-Seq_HELA_Human0.67789317
120BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.67204010
121STAT4_19710469_ChIP-ChIP_TH1__Mouse0.66028002
122SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.62435933

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication4.80623690
2MP0010094_abnormal_chromosome_stability4.34255104
3MP0003693_abnormal_embryo_hatching4.22753953
4MP0008058_abnormal_DNA_repair3.88015558
5MP0003111_abnormal_nucleus_morphology3.72453538
6MP0008877_abnormal_DNA_methylation3.66491599
7MP0003077_abnormal_cell_cycle3.34586984
8MP0004957_abnormal_blastocyst_morpholog3.00107339
9MP0006292_abnormal_olfactory_placode2.97500640
10MP0008007_abnormal_cellular_replicative2.90317372
11MP0002396_abnormal_hematopoietic_system2.38227157
12MP0008932_abnormal_embryonic_tissue2.12722350
13MP0006035_abnormal_mitochondrial_morpho1.97190829
14MP0005410_abnormal_fertilization1.96928857
15MP0003195_calcinosis1.96370904
16MP0003786_premature_aging1.95001514
17MP0008789_abnormal_olfactory_epithelium1.94553283
18MP0001929_abnormal_gametogenesis1.94117228
19MP0000569_abnormal_digit_pigmentation1.91364670
20MP0002210_abnormal_sex_determination1.90094707
21MP0003787_abnormal_imprinting1.79922474
22MP0006036_abnormal_mitochondrial_physio1.76788012
23MP0004808_abnormal_hematopoietic_stem1.72411723
24MP0001188_hyperpigmentation1.72172973
25MP0002163_abnormal_gland_morphology1.69243739
26MP0002638_abnormal_pupillary_reflex1.68002824
27MP0005499_abnormal_olfactory_system1.64928554
28MP0005394_taste/olfaction_phenotype1.64928554
29MP0001986_abnormal_taste_sensitivity1.58143771
30MP0003698_abnormal_male_reproductive1.57922041
31MP0005671_abnormal_response_to1.57414012
32MP0003806_abnormal_nucleotide_metabolis1.56323096
33MP0003121_genomic_imprinting1.54568604
34MP0001145_abnormal_male_reproductive1.53458767
35MP0000490_abnormal_crypts_of1.53325433
36MP0000350_abnormal_cell_proliferation1.51527992
37MP0003136_yellow_coat_color1.50535661
38MP0001764_abnormal_homeostasis1.49826152
39MP0003763_abnormal_thymus_physiology1.48770673
40MP0003186_abnormal_redox_activity1.43662519
41MP0000653_abnormal_sex_gland1.43383814
42MP0000015_abnormal_ear_pigmentation1.43116262
43MP0005174_abnormal_tail_pigmentation1.42576430
44MP0003718_maternal_effect1.40725245
45MP0002138_abnormal_hepatobiliary_system1.40399266
46MP0002095_abnormal_skin_pigmentation1.36599203
47MP0005367_renal/urinary_system_phenotyp1.34229393
48MP0000516_abnormal_urinary_system1.34229393
49MP0002398_abnormal_bone_marrow1.33630557
50MP0000358_abnormal_cell_content/1.33494888
51MP0001835_abnormal_antigen_presentation1.27605309
52MP0005075_abnormal_melanosome_morpholog1.27365415
53MP0000313_abnormal_cell_death1.27109022
54MP0000703_abnormal_thymus_morphology1.25668299
55MP0002102_abnormal_ear_morphology1.21934496
56MP0001730_embryonic_growth_arrest1.21345749
57MP0002938_white_spotting1.20212591
58MP0003123_paternal_imprinting1.18328013
59MP0003646_muscle_fatigue1.15081782
60MP0005409_darkened_coat_color1.14646872
61MP0002019_abnormal_tumor_incidence1.13278493
62MP0002751_abnormal_autonomic_nervous1.12686933
63MP0008995_early_reproductive_senescence1.12092538
64MP0001545_abnormal_hematopoietic_system1.10119280
65MP0005397_hematopoietic_system_phenotyp1.10119280
66MP0010307_abnormal_tumor_latency1.09597150
67MP0002132_abnormal_respiratory_system1.07328216
68MP0001984_abnormal_olfaction1.06637916
69MP0001293_anophthalmia1.05253765
70MP0002722_abnormal_immune_system1.04640339
71MP0009333_abnormal_splenocyte_physiolog1.04147614
72MP0008260_abnormal_autophagy1.03868642
73MP0000689_abnormal_spleen_morphology1.03355615
74MP0001800_abnormal_humoral_immune1.03338051
75MP0001119_abnormal_female_reproductive1.02118868
76MP0005379_endocrine/exocrine_gland_phen1.01528258
77MP0006072_abnormal_retinal_apoptosis0.98904746
78MP0000716_abnormal_immune_system0.98794528
79MP0002160_abnormal_reproductive_system0.98716476
80MP0002420_abnormal_adaptive_immunity0.97843125
81MP0001324_abnormal_eye_pigmentation0.97585000
82MP0000647_abnormal_sebaceous_gland0.97057559
83MP0005380_embryogenesis_phenotype0.96244696
84MP0001672_abnormal_embryogenesis/_devel0.96244696
85MP0001819_abnormal_immune_cell0.96244325
86MP0002161_abnormal_fertility/fecundity0.96124384
87MP0005084_abnormal_gallbladder_morpholo0.95678352
88MP0001697_abnormal_embryo_size0.95366305
89MP0002429_abnormal_blood_cell0.94454301
90MP0002452_abnormal_antigen_presenting0.94416890
91MP0002085_abnormal_embryonic_tissue0.91873840
92MP0000631_abnormal_neuroendocrine_gland0.91475998
93MP0009697_abnormal_copulation0.91079389
94MP0002723_abnormal_immune_serum0.90953073
95MP0000566_synostosis0.90055426
96MP0004147_increased_porphyrin_level0.89959635
97MP0002080_prenatal_lethality0.88097742
98MP0002837_dystrophic_cardiac_calcinosis0.87614359
99MP0002822_catalepsy0.87090916
100MP0004381_abnormal_hair_follicle0.86847824
101MP0003221_abnormal_cardiomyocyte_apopto0.86498563
102MP0009046_muscle_twitch0.85013094
103MP0002148_abnormal_hypersensitivity_rea0.82979461
104MP0003937_abnormal_limbs/digits/tail_de0.82293672
105MP0005645_abnormal_hypothalamus_physiol0.81662029
106MP0006054_spinal_hemorrhage0.81397108
107MP0003984_embryonic_growth_retardation0.80413941
108MP0002277_abnormal_respiratory_mucosa0.79775422
109MP0002233_abnormal_nose_morphology0.78662123
110MP0005408_hypopigmentation0.77339701
111MP0000427_abnormal_hair_cycle0.76865524
112MP0003567_abnormal_fetal_cardiomyocyte0.76058364
113MP0004215_abnormal_myocardial_fiber0.75717614
114MP0002084_abnormal_developmental_patter0.75179412
115MP0009785_altered_susceptibility_to0.75050524
116MP0002088_abnormal_embryonic_growth/wei0.74907936
117MP0005253_abnormal_eye_physiology0.74591193
118MP0005000_abnormal_immune_tolerance0.74070050
119MP0001919_abnormal_reproductive_system0.74042496
120MP0003890_abnormal_embryonic-extraembry0.73639311
121MP0005551_abnormal_eye_electrophysiolog0.73599005
122MP0008872_abnormal_physiological_respon0.73338903
123MP0003315_abnormal_perineum_morphology0.73234651
124MP0006276_abnormal_autonomic_nervous0.72512975
125MP0005171_absent_coat_pigmentation0.72438887
126MP0005395_other_phenotype0.71880849
127MP0004142_abnormal_muscle_tone0.71211872
128MP0005389_reproductive_system_phenotype0.70746276
129MP0002405_respiratory_system_inflammati0.70232452
130MP0005220_abnormal_exocrine_pancreas0.69927488
131MP0005025_abnormal_response_to0.69681136
132MP0002090_abnormal_vision0.68165043
133MP0001529_abnormal_vocalization0.67541560
134MP0003119_abnormal_digestive_system0.66270896
135MP0002075_abnormal_coat/hair_pigmentati0.66240504
136MP0002653_abnormal_ependyma_morphology0.66200432
137MP0000372_irregular_coat_pigmentation0.64643715
138* MP0004197_abnormal_fetal_growth/weight/0.64124724
139MP0004133_heterotaxia0.64067800
140MP0001186_pigmentation_phenotype0.63369246
141MP0005391_vision/eye_phenotype0.62808000
142MP0003943_abnormal_hepatobiliary_system0.61849417
143MP0001286_abnormal_eye_development0.61400685

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)4.36172853
2Chromsome breakage (HP:0040012)4.28019039
3Birth length less than 3rd percentile (HP:0003561)4.07286750
4Acute necrotizing encephalopathy (HP:0006965)3.48354876
5Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.45464778
6Increased CSF lactate (HP:0002490)3.37000542
7Mitochondrial inheritance (HP:0001427)3.25996873
8Reticulocytopenia (HP:0001896)3.24814427
9Supernumerary spleens (HP:0009799)3.23885022
10Abnormality of chromosome stability (HP:0003220)3.23572198
11Methylmalonic acidemia (HP:0002912)3.21479716
12Acute encephalopathy (HP:0006846)3.19672890
13Abnormal mitochondria in muscle tissue (HP:0008316)3.15591352
14Meckel diverticulum (HP:0002245)3.13424120
15Abnormality of the preputium (HP:0100587)3.09732717
16Dynein arm defect of respiratory motile cilia (HP:0012255)3.05828239
17Absent/shortened dynein arms (HP:0200106)3.05828239
18Progressive macrocephaly (HP:0004481)3.04750369
19Increased hepatocellular lipid droplets (HP:0006565)2.97154187
20Abnormality of the ileum (HP:0001549)2.95994536
21Hepatocellular necrosis (HP:0001404)2.95128428
22Lipid accumulation in hepatocytes (HP:0006561)2.94690202
23Methylmalonic aciduria (HP:0012120)2.94290706
24Aplasia/Hypoplasia of the uvula (HP:0010293)2.92582017
25Volvulus (HP:0002580)2.92314694
263-Methylglutaconic aciduria (HP:0003535)2.89966688
27Hepatic necrosis (HP:0002605)2.89906859
28Abnormal number of erythroid precursors (HP:0012131)2.81602296
29Increased serum lactate (HP:0002151)2.77124257
30Hyperglycinemia (HP:0002154)2.75869149
31Abnormality of cells of the erythroid lineage (HP:0012130)2.69720240
32Abnormality of glycolysis (HP:0004366)2.60151851
33Ectopic kidney (HP:0000086)2.59665070
34Impulsivity (HP:0100710)2.57086419
35Abnormal respiratory motile cilium physiology (HP:0012261)2.56418939
36Abnormal respiratory motile cilium morphology (HP:0005938)2.56164919
37Abnormal respiratory epithelium morphology (HP:0012253)2.56164919
38Pancreatic cysts (HP:0001737)2.55314324
39Small intestinal stenosis (HP:0012848)2.54277146
40Duodenal stenosis (HP:0100867)2.54277146
41Increased serum pyruvate (HP:0003542)2.52256731
42Nephrogenic diabetes insipidus (HP:0009806)2.51096260
43Myelodysplasia (HP:0002863)2.49579007
44Breast hypoplasia (HP:0003187)2.47448694
45Pancreatic fibrosis (HP:0100732)2.47308609
46Sloping forehead (HP:0000340)2.43851198
47Patellar aplasia (HP:0006443)2.43730231
48Nephroblastoma (Wilms tumor) (HP:0002667)2.41528216
49Clubbing of toes (HP:0100760)2.41270057
50Duplicated collecting system (HP:0000081)2.40559301
51Abnormality of alanine metabolism (HP:0010916)2.40290763
52Hyperalaninemia (HP:0003348)2.40290763
53Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.40290763
54Type I transferrin isoform profile (HP:0003642)2.38683552
55Lactic acidosis (HP:0003128)2.36174518
56Abnormal ciliary motility (HP:0012262)2.32353892
57Medulloblastoma (HP:0002885)2.31157096
58Cerebral edema (HP:0002181)2.30943710
59Bone marrow hypocellularity (HP:0005528)2.30057932
60Renal Fanconi syndrome (HP:0001994)2.27992135
61Aplastic anemia (HP:0001915)2.27146919
62Congenital primary aphakia (HP:0007707)2.26411832
63Acute lymphatic leukemia (HP:0006721)2.25967759
64Abnormal spermatogenesis (HP:0008669)2.24815187
65Aplasia/Hypoplasia of the patella (HP:0006498)2.24471488
66Embryonal renal neoplasm (HP:0011794)2.22689420
67Hypothermia (HP:0002045)2.19138153
68Abnormality of the renal collecting system (HP:0004742)2.18941947
69Abnormal biliary tract physiology (HP:0012439)2.16839409
70Bile duct proliferation (HP:0001408)2.16839409
71Colon cancer (HP:0003003)2.15403128
72Abnormality of DNA repair (HP:0003254)2.15318349
73Microvesicular hepatic steatosis (HP:0001414)2.14397352
74Gait imbalance (HP:0002141)2.12991639
75Rhinitis (HP:0012384)2.12927795
76Nephronophthisis (HP:0000090)2.11697241
77Increased intramyocellular lipid droplets (HP:0012240)2.10104445
78Premature graying of hair (HP:0002216)2.08591028
79Agnosia (HP:0010524)2.08561367
80True hermaphroditism (HP:0010459)2.08461463
81Abnormality of the pons (HP:0007361)2.07319952
82Abnormal lung lobation (HP:0002101)2.03808591
83Pallor (HP:0000980)2.02918028
84Abnormality of the duodenum (HP:0002246)2.02706888
85Abnormality of the columella (HP:0009929)2.02375991
86Acute myeloid leukemia (HP:0004808)2.02132616
87Decreased activity of mitochondrial respiratory chain (HP:0008972)2.02009545
88Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.02009545
89Abnormality of the heme biosynthetic pathway (HP:0010472)2.01888569
90Abnormality of methionine metabolism (HP:0010901)2.00686908
91Abnormality of serum amino acid levels (HP:0003112)2.00535277
92Cerebral hypomyelination (HP:0006808)1.99137568
93Abnormality of the carotid arteries (HP:0005344)1.96644624
94Hypoplasia of the capital femoral epiphysis (HP:0003090)1.96495616
95Abnormality of glycine metabolism (HP:0010895)1.95191603
96Abnormality of serine family amino acid metabolism (HP:0010894)1.95191603
97Triphalangeal thumb (HP:0001199)1.95054568
98Lymphoma (HP:0002665)1.95022558
99Hypoplasia of the pons (HP:0012110)1.94466670
100Absent thumb (HP:0009777)1.94451449
101Aplasia/hypoplasia of the uterus (HP:0008684)1.94167927
102Lethargy (HP:0001254)1.94102023
103Retrobulbar optic neuritis (HP:0100654)1.93614681
104Optic neuritis (HP:0100653)1.93614681
105Cleft eyelid (HP:0000625)1.93596314
106Genital tract atresia (HP:0001827)1.92820683
107Optic disc pallor (HP:0000543)1.92478365
108Severe visual impairment (HP:0001141)1.92455808
109Congenital stationary night blindness (HP:0007642)1.92135962
110Respiratory difficulties (HP:0002880)1.90634521
111Attenuation of retinal blood vessels (HP:0007843)1.90420151
112Carpal bone hypoplasia (HP:0001498)1.90301893
113Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.89187578
114Abnormal hair whorl (HP:0010721)1.88229431
115IgM deficiency (HP:0002850)1.88031387
116Medial flaring of the eyebrow (HP:0010747)1.87099649
117Respiratory failure (HP:0002878)1.85747992
118Abnormality of the fingertips (HP:0001211)1.85139488
119Macrocytic anemia (HP:0001972)1.85097909
120Abnormality of the labia minora (HP:0012880)1.84969600
121IgG deficiency (HP:0004315)1.84791458
122Reduced antithrombin III activity (HP:0001976)1.84015828
123Exercise intolerance (HP:0003546)1.83362342
124Progressive inability to walk (HP:0002505)1.83124959
125Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.82916204
126Abnormal protein N-linked glycosylation (HP:0012347)1.82916204
127Abnormal protein glycosylation (HP:0012346)1.82916204
128Abnormal glycosylation (HP:0012345)1.82916204
129Exertional dyspnea (HP:0002875)1.81767840
130Oral leukoplakia (HP:0002745)1.80908226
131Selective tooth agenesis (HP:0001592)1.79716918
132Dry hair (HP:0011359)1.79689219
133Bronchiectasis (HP:0002110)1.79237820
134Renal cortical cysts (HP:0000803)1.78623056
135Rough bone trabeculation (HP:0100670)1.78552284
136Pancytopenia (HP:0001876)1.78250656
137Increased muscle lipid content (HP:0009058)1.78122027
138Pendular nystagmus (HP:0012043)1.77123841
139Abnormality of the vitamin B12 metabolism (HP:0004341)1.75253273
140Type 2 muscle fiber atrophy (HP:0003554)1.75197096
141Horseshoe kidney (HP:0000085)1.75085377
142Abnormality of vitamin B metabolism (HP:0004340)1.75012571
143Abnormality of the anterior horn cell (HP:0006802)1.74953566
144Degeneration of anterior horn cells (HP:0002398)1.74953566
14511 pairs of ribs (HP:0000878)1.74392695
146Absent radius (HP:0003974)1.74249664
147Postnatal microcephaly (HP:0005484)1.74185672
148Anencephaly (HP:0002323)1.74042815
149Prominent nose (HP:0000448)1.73559052
150Neoplasm of the adrenal gland (HP:0100631)1.73476576
151Short thumb (HP:0009778)1.72442470
152Vaginal atresia (HP:0000148)1.72384822
153Abnormal number of incisors (HP:0011064)1.72184572
154Thrombocytosis (HP:0001894)1.69531253
155Lissencephaly (HP:0001339)1.69300039
156CNS demyelination (HP:0007305)1.68429477
157Molar tooth sign on MRI (HP:0002419)1.68026218
158Abnormality of midbrain morphology (HP:0002418)1.68026218
159Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.67454087
160Asplenia (HP:0001746)1.67421971
161Retinal dysplasia (HP:0007973)1.67406336
162CNS hypomyelination (HP:0003429)1.67376607
163Aplasia/Hypoplasia of the earlobes (HP:0009906)1.67096613
164Neoplasm of the oral cavity (HP:0100649)1.66877835
165Abnormality of dicarboxylic acid metabolism (HP:0010995)1.66306763
166Dicarboxylic aciduria (HP:0003215)1.66306763

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIM283.61054138
2CDC73.55522687
3BUB13.46114329
4WEE13.46088819
5PLK43.42264672
6SRPK13.03587237
7TLK12.74648205
8EIF2AK12.70476050
9MAP4K22.70465880
10STK162.57884899
11NEK22.54195506
12VRK12.50413617
13MKNK22.49201133
14MKNK12.30698488
15VRK22.27127417
16EIF2AK32.19892661
17NEK12.18901378
18FRK2.11188463
19DYRK32.06553760
20WNK31.99328350
21TTK1.89098526
22ACVR1B1.88114328
23ZAK1.81376460
24ATR1.79826275
25TNIK1.78127761
26BRD41.72444569
27BRSK21.72156028
28BCKDK1.71486328
29PLK11.65130982
30CDK121.62191774
31EIF2AK21.61224090
32TXK1.55414107
33TAF11.51927869
34CHEK21.51209782
35CSNK1G31.49404762
36CSNK1G11.49335861
37PLK31.47918089
38CCNB11.47713855
39CLK11.46791155
40TSSK61.45287489
41PDK21.42082091
42CDK71.39499184
43AURKB1.38219366
44CDK191.35840100
45IRAK41.33669993
46IRAK31.27383443
47PBK1.25748104
48CSNK1G21.22807208
49MAP3K41.20069659
50CHEK11.19351591
51ERBB31.16655146
52PNCK1.15687403
53STK41.13910351
54NEK61.11848347
55PASK1.05332137
56YES11.00348898
57ATM0.99517521
58IRAK20.88536496
59OXSR10.85750085
60BMPR1B0.85662049
61SIK30.85052927
62TEC0.84781006
63CASK0.81904835
64CDK30.81113823
65CDK40.79922957
66BRAF0.79035219
67FLT30.74364343
68STK30.74073739
69CDK80.74003959
70KIT0.72643080
71PLK20.71826655
72NME20.71681669
73CDK20.71406649
74RPS6KA50.70860724
75NME10.70223741
76AURKA0.69213554
77BRSK10.68593132
78PIM10.66740045
79CDK10.65796076
80BTK0.64127056
81NLK0.60468118
82IRAK10.57294933
83MAP4K10.57249975
84PIM20.57120636
85INSRR0.56657884
86CSNK2A10.55808821
87CSNK2A20.54981954
88PINK10.52852847
89RPS6KA40.51508712
90STK240.51049485
91TAOK30.51049273
92DYRK20.50450110
93MST40.50058140
94IKBKB0.49880207
95STK100.49555650
96RPS6KB20.49301718
97RAF10.48250643
98LYN0.46952345
99BCR0.46890550
100CDK90.45817696
101ADRBK20.45136398
102JAK30.43500327
103STK390.43265264
104STK38L0.42716837
105CSF1R0.41809745
106MARK30.41046824
107MAPK130.40059724
108PRKCE0.38559459
109PRKDC0.38439499
110BMPR20.37714152
111MUSK0.37508069
112AKT30.36362537
113MAP2K70.36212578
114NUAK10.34806272
115GRK10.34489711
116CSNK1E0.34470039
117PAK30.33443564
118IKBKE0.33103619
119CSNK1A10.32804485
120TGFBR10.32547749
121MAP3K60.31686760
122CSNK1D0.30112208
123PAK10.30036381
124MAPK140.29817936
125LCK0.29391788
126FGFR20.29283084
127PRKCG0.27269418
128GSK3B0.26349348
129DYRK1A0.25721113
130PRKCI0.24126754
131MAP3K80.22404344
132ZAP700.19673245
133CSNK1A1L0.19641157

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.18056148
2Mismatch repair_Homo sapiens_hsa034303.59353062
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.37282242
4RNA polymerase_Homo sapiens_hsa030203.37018332
5Homologous recombination_Homo sapiens_hsa034403.25499707
6Spliceosome_Homo sapiens_hsa030403.04689459
7Fanconi anemia pathway_Homo sapiens_hsa034602.99977267
8Ribosome_Homo sapiens_hsa030102.91092792
9Non-homologous end-joining_Homo sapiens_hsa034502.77119267
10* Basal transcription factors_Homo sapiens_hsa030222.69428487
11Nucleotide excision repair_Homo sapiens_hsa034202.64148398
12Cell cycle_Homo sapiens_hsa041102.62414897
13RNA transport_Homo sapiens_hsa030132.61970047
14Base excision repair_Homo sapiens_hsa034102.51973388
15Proteasome_Homo sapiens_hsa030502.48333931
16Pyrimidine metabolism_Homo sapiens_hsa002402.33841915
17RNA degradation_Homo sapiens_hsa030182.02012508
18Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.87628971
19Propanoate metabolism_Homo sapiens_hsa006401.76097226
20One carbon pool by folate_Homo sapiens_hsa006701.75560214
21Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.73494420
22mRNA surveillance pathway_Homo sapiens_hsa030151.73203871
23Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.62699479
24Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.60872822
25Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.57714065
26Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.54015228
27Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.51465432
28Purine metabolism_Homo sapiens_hsa002301.51105163
29Cysteine and methionine metabolism_Homo sapiens_hsa002701.50142065
30Fatty acid elongation_Homo sapiens_hsa000621.42687910
31p53 signaling pathway_Homo sapiens_hsa041151.41790304
32Steroid biosynthesis_Homo sapiens_hsa001001.37674770
33Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.36631622
34Protein export_Homo sapiens_hsa030601.33824150
35* Herpes simplex infection_Homo sapiens_hsa051681.30876733
36Primary immunodeficiency_Homo sapiens_hsa053401.27929258
37Systemic lupus erythematosus_Homo sapiens_hsa053221.26962002
38* Epstein-Barr virus infection_Homo sapiens_hsa051691.20804788
39Phototransduction_Homo sapiens_hsa047441.17343622
40Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.13801885
41Pyruvate metabolism_Homo sapiens_hsa006201.11128777
42Alzheimers disease_Homo sapiens_hsa050101.10830082
43Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.06484085
44Butanoate metabolism_Homo sapiens_hsa006501.06056901
45Vitamin B6 metabolism_Homo sapiens_hsa007501.04625539
46Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.03933812
47NF-kappa B signaling pathway_Homo sapiens_hsa040640.99782778
48Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.98240818
49Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.97892377
502-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.95589887
51Oocyte meiosis_Homo sapiens_hsa041140.91412966
52Intestinal immune network for IgA production_Homo sapiens_hsa046720.88313516
53Measles_Homo sapiens_hsa051620.87878998
54Peroxisome_Homo sapiens_hsa041460.84915903
55* Viral carcinogenesis_Homo sapiens_hsa052030.81699607
56Antigen processing and presentation_Homo sapiens_hsa046120.80268736
57Transcriptional misregulation in cancer_Homo sapiens_hsa052020.79563470
58Hematopoietic cell lineage_Homo sapiens_hsa046400.72256586
59Allograft rejection_Homo sapiens_hsa053300.70089297
60NOD-like receptor signaling pathway_Homo sapiens_hsa046210.68904686
61Carbon metabolism_Homo sapiens_hsa012000.66371905
62Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.65492606
63Huntingtons disease_Homo sapiens_hsa050160.64520766
64Alcoholism_Homo sapiens_hsa050340.63148277
65Collecting duct acid secretion_Homo sapiens_hsa049660.62048896
66RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.61567218
67Asthma_Homo sapiens_hsa053100.60983872
68Pentose phosphate pathway_Homo sapiens_hsa000300.59845770
69Sulfur metabolism_Homo sapiens_hsa009200.59414269
70Sulfur relay system_Homo sapiens_hsa041220.59224467
71Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.58171484
72Autoimmune thyroid disease_Homo sapiens_hsa053200.57434919
73Glutathione metabolism_Homo sapiens_hsa004800.56786816
74Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.56500177
75N-Glycan biosynthesis_Homo sapiens_hsa005100.54362604
76Maturity onset diabetes of the young_Homo sapiens_hsa049500.52810353
77Biosynthesis of amino acids_Homo sapiens_hsa012300.52232346
78SNARE interactions in vesicular transport_Homo sapiens_hsa041300.50922782
79* HTLV-I infection_Homo sapiens_hsa051660.50414302
80Influenza A_Homo sapiens_hsa051640.50230001
81Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.49462854
82Regulation of autophagy_Homo sapiens_hsa041400.48323780
83Tryptophan metabolism_Homo sapiens_hsa003800.47535792
84Nitrogen metabolism_Homo sapiens_hsa009100.47386433
85Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.46910805
86Graft-versus-host disease_Homo sapiens_hsa053320.46497355
87Sphingolipid metabolism_Homo sapiens_hsa006000.46460964
88Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.45151873
89Hepatitis B_Homo sapiens_hsa051610.45008005
90Legionellosis_Homo sapiens_hsa051340.43996266
91Jak-STAT signaling pathway_Homo sapiens_hsa046300.43723929
92Arachidonic acid metabolism_Homo sapiens_hsa005900.40963599
93Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.40363314
94Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.39787125
95Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.39394025
96Fatty acid metabolism_Homo sapiens_hsa012120.38361174
97T cell receptor signaling pathway_Homo sapiens_hsa046600.36821629
98Cardiac muscle contraction_Homo sapiens_hsa042600.36622129
99MicroRNAs in cancer_Homo sapiens_hsa052060.36600810
100Caffeine metabolism_Homo sapiens_hsa002320.35819786
101beta-Alanine metabolism_Homo sapiens_hsa004100.35138307
102Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.34724770
103Folate biosynthesis_Homo sapiens_hsa007900.34199418
104Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.32979414
105Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.32834589
106Ether lipid metabolism_Homo sapiens_hsa005650.32632685
107Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.31087001
108Drug metabolism - other enzymes_Homo sapiens_hsa009830.29432889
109Notch signaling pathway_Homo sapiens_hsa043300.28810843
110Circadian rhythm_Homo sapiens_hsa047100.28576168
111Linoleic acid metabolism_Homo sapiens_hsa005910.27179382
112Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.26884301
113Shigellosis_Homo sapiens_hsa051310.25993549
114Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.25916770
115Small cell lung cancer_Homo sapiens_hsa052220.25659225
116Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.25455492
117Apoptosis_Homo sapiens_hsa042100.25281493
118Toll-like receptor signaling pathway_Homo sapiens_hsa046200.23957214
119Selenocompound metabolism_Homo sapiens_hsa004500.23944112
120Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.23343143
121Vitamin digestion and absorption_Homo sapiens_hsa049770.23010839
122B cell receptor signaling pathway_Homo sapiens_hsa046620.22929164
123alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.22765514
124Parkinsons disease_Homo sapiens_hsa050120.22346737
125TGF-beta signaling pathway_Homo sapiens_hsa043500.21493601
126Other glycan degradation_Homo sapiens_hsa005110.21465644
127Wnt signaling pathway_Homo sapiens_hsa043100.20896097
128Acute myeloid leukemia_Homo sapiens_hsa052210.20877407
129Oxidative phosphorylation_Homo sapiens_hsa001900.20487161
130Malaria_Homo sapiens_hsa051440.20032727
131Leishmaniasis_Homo sapiens_hsa051400.18539957
132Prostate cancer_Homo sapiens_hsa052150.18089729
133Olfactory transduction_Homo sapiens_hsa047400.17842946
134Type I diabetes mellitus_Homo sapiens_hsa049400.17825585
135Arginine and proline metabolism_Homo sapiens_hsa003300.17362657
136Thyroid cancer_Homo sapiens_hsa052160.17035020
137Pathways in cancer_Homo sapiens_hsa052000.17017499
138Renin-angiotensin system_Homo sapiens_hsa046140.16093889
139Colorectal cancer_Homo sapiens_hsa052100.14550905
140FoxO signaling pathway_Homo sapiens_hsa040680.14221801
141Rheumatoid arthritis_Homo sapiens_hsa053230.13971654
142Metabolic pathways_Homo sapiens_hsa011000.13908643
143Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.12249445
144Pentose and glucuronate interconversions_Homo sapiens_hsa000400.12137052
145Lysine degradation_Homo sapiens_hsa003100.11105352

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