TBL1X

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene has sequence similarity with members of the WD40 repeat-containing protein family. The WD40 group is a large family of proteins, which appear to have a regulatory function. It is believed that the WD40 repeats mediate protein-protein interactions and members of the family are involved in signal transduction, RNA processing, gene regulation, vesicular trafficking, cytoskeletal assembly and may play a role in the control of cytotypic differentiation. This encoded protein is found as a subunit in corepressor SMRT (silencing mediator for retinoid and thyroid receptors) complex along with histone deacetylase 3 protein. This gene is located adjacent to the ocular albinism gene and it is thought to be involved in the pathogenesis of the ocular albinism with late-onset sensorineural deafness phenotype. Four transcript variants encoding two different isoforms have been found for this gene. This gene is highly similar to the Y chromosome TBL1Y gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.39859197
2positive regulation by organism of defense response of other organism involved in symbiotic interact5.39859197
3modulation by symbiont of host immune response (GO:0052553)5.39859197
4positive regulation by symbiont of host defense response (GO:0052509)5.39859197
5modulation by symbiont of host defense response (GO:0052031)5.39859197
6modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.39859197
7COPI coating of Golgi vesicle (GO:0048205)5.14912607
8Golgi transport vesicle coating (GO:0048200)5.14912607
9antigen processing and presentation via MHC class Ib (GO:0002475)4.76225270
10regulation of histone H3-K27 methylation (GO:0061085)4.60311733
11negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.46658117
12negative regulation of cell killing (GO:0031342)4.46658117
13regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.43994645
14mitotic sister chromatid cohesion (GO:0007064)4.41834987
15detection of molecule of bacterial origin (GO:0032490)4.22793382
16nuclear pore complex assembly (GO:0051292)4.17881074
17regulation of branching involved in prostate gland morphogenesis (GO:0060687)4.04194036
18glucocorticoid receptor signaling pathway (GO:0042921)3.99547611
19nuclear pore organization (GO:0006999)3.88506813
20pre-miRNA processing (GO:0031054)3.87634629
21response to interleukin-15 (GO:0070672)3.84137787
22positive regulation of gamma-delta T cell activation (GO:0046645)3.83792713
23production of molecular mediator involved in inflammatory response (GO:0002532)3.82169595
24antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.76813180
25negative regulation of cAMP-mediated signaling (GO:0043951)3.67645270
26leukocyte migration involved in inflammatory response (GO:0002523)3.62682827
27histone H3-K36 demethylation (GO:0070544)3.60787165
28leukocyte aggregation (GO:0070486)3.56236783
29insulin-like growth factor receptor signaling pathway (GO:0048009)3.46686297
30hippo signaling (GO:0035329)3.44451143
31maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.40897330
32exocrine pancreas development (GO:0031017)3.39425992
33cellular response to interleukin-15 (GO:0071350)3.39198534
34corticosteroid receptor signaling pathway (GO:0031958)3.39030103
35positive regulation of histone deacetylation (GO:0031065)3.33643437
36cytoplasmic mRNA processing body assembly (GO:0033962)3.31324905
37regulation of gamma-delta T cell activation (GO:0046643)3.30878244
38hepatocyte apoptotic process (GO:0097284)3.30075626
39tolerance induction (GO:0002507)3.26759872
40regulation of B cell receptor signaling pathway (GO:0050855)3.24629896
41regulation of DNA endoreduplication (GO:0032875)3.24030149
42negative regulation of execution phase of apoptosis (GO:1900118)3.22174225
43DNA unwinding involved in DNA replication (GO:0006268)3.21361454
44neutrophil activation involved in immune response (GO:0002283)3.20405302
45regulation of gamma-delta T cell differentiation (GO:0045586)3.17862149
46histone H3-K4 trimethylation (GO:0080182)3.17211767
47regulation of RNA export from nucleus (GO:0046831)3.14455078
48activation of signaling protein activity involved in unfolded protein response (GO:0006987)3.14353931
49response to host (GO:0075136)3.13123432
50response to host defenses (GO:0052200)3.13123432
51response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.13123432
52regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.12255925
53peptidyl-lysine dimethylation (GO:0018027)3.11200751
54detection of external biotic stimulus (GO:0098581)3.10416402
55positive regulation of hormone biosynthetic process (GO:0046886)3.09355168
56positive regulation of nuclease activity (GO:0032075)3.08852268
57response to host immune response (GO:0052572)3.05739150
58response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.05739150
59COPII vesicle coating (GO:0048208)3.05535846
60polarized epithelial cell differentiation (GO:0030859)3.05280349
61macrophage activation involved in immune response (GO:0002281)3.05227069
62heterochromatin organization (GO:0070828)3.04224729
63regulation of histone H3-K4 methylation (GO:0051569)3.03472288
64regulation of interferon-beta biosynthetic process (GO:0045357)3.02688256
65L-alpha-amino acid transmembrane transport (GO:1902475)3.02354688
66ear development (GO:0043583)3.01036182
67dorsal/ventral axis specification (GO:0009950)2.98453535
68positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.98447955
69neutrophil activation (GO:0042119)2.97065400
70negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.96011509
71NLS-bearing protein import into nucleus (GO:0006607)2.94954609
72antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.91658051
73planar cell polarity pathway involved in neural tube closure (GO:0090179)2.90238055
74interferon-gamma secretion (GO:0072643)2.88440065
75positive regulation of SMAD protein import into nucleus (GO:0060391)2.88308654
76cellular extravasation (GO:0045123)2.88286097
77positive regulation of transcription from RNA polymerase III promoter (GO:0045945)2.87432052
78negative regulation of lymphocyte mediated immunity (GO:0002707)2.86819812
79protein retention in ER lumen (GO:0006621)2.84197345
80regulation of nuclease activity (GO:0032069)2.83689941
81detection of biotic stimulus (GO:0009595)2.81245384
82type B pancreatic cell development (GO:0003323)2.80851193
83RNA stabilization (GO:0043489)2.79620894
84mRNA stabilization (GO:0048255)2.79620894
85pore complex assembly (GO:0046931)2.79312603
86negative regulation of fatty acid transport (GO:2000192)2.78318535
87histone deubiquitination (GO:0016578)2.77300558
88embryonic foregut morphogenesis (GO:0048617)2.77002103
89positive regulation by host of viral transcription (GO:0043923)2.76223363
90protein localization to microtubule (GO:0035372)2.75275951
91glandular epithelial cell development (GO:0002068)2.75257460
92detection of other organism (GO:0098543)2.74551621
93paraxial mesoderm development (GO:0048339)2.74103255
94negative regulation of DNA repair (GO:0045738)2.70807549
95regulation of translational fidelity (GO:0006450)2.70683016
96regulation of histone methylation (GO:0031060)2.70281507
97body morphogenesis (GO:0010171)2.69919063
98dosage compensation (GO:0007549)2.68123243
99phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.67541642
100negative thymic T cell selection (GO:0045060)2.66126945
101retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.65877855
102embryonic camera-type eye morphogenesis (GO:0048596)2.65505282
103negative T cell selection (GO:0043383)2.65073799
104endoplasmic reticulum unfolded protein response (GO:0030968)2.64919499
105histone H4-K16 acetylation (GO:0043984)2.64259038
106granulocyte activation (GO:0036230)2.64114805
107regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.63998012
108radial glial cell differentiation (GO:0060019)2.63825251
109negative regulation of histone methylation (GO:0031061)2.62591136
110histone lysine demethylation (GO:0070076)2.61699130
111regulation of SMAD protein import into nucleus (GO:0060390)2.59594768
112vesicle coating (GO:0006901)2.59137904
113positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.58767742
114embryonic process involved in female pregnancy (GO:0060136)2.58393849
115respiratory burst (GO:0045730)2.58085246
116histone H3-K4 methylation (GO:0051568)2.57612048
117positive regulation of glycogen biosynthetic process (GO:0045725)2.56632061
118antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.55893793
119response to peptidoglycan (GO:0032494)2.54196985
120growth hormone receptor signaling pathway (GO:0060396)2.53960407
121regulation of extracellular matrix disassembly (GO:0010715)2.53062198
122protein heterotrimerization (GO:0070208)2.52604026
123cellular response to unfolded protein (GO:0034620)2.52513817
124renal filtration (GO:0097205)2.51426562
125prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060522.51001374
126regulation of stem cell maintenance (GO:2000036)2.50995815
127negative regulation of glycogen biosynthetic process (GO:0045719)2.50211574
128negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.50189574
129positive regulation of histone H3-K4 methylation (GO:0051571)2.50103395
130cell migration involved in sprouting angiogenesis (GO:0002042)2.49749873
131thymic T cell selection (GO:0045061)2.49513010
132heart morphogenesis (GO:0003007)2.47930512
133ER-nucleus signaling pathway (GO:0006984)2.44834943
134coronary vasculature morphogenesis (GO:0060977)2.43318128
135regulation of chromatin binding (GO:0035561)2.42831094
136antigen processing and presentation of endogenous antigen (GO:0019883)2.42802241
137primitive streak formation (GO:0090009)2.42615616
138DNA duplex unwinding (GO:0032508)2.42535078
139negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.42266680
140chondrocyte development (GO:0002063)2.42216805
141regulation of establishment of planar polarity (GO:0090175)2.42160153
142folic acid-containing compound biosynthetic process (GO:0009396)2.41690126
143positive regulation of hormone metabolic process (GO:0032352)2.41533855
144regulation of intracellular estrogen receptor signaling pathway (GO:0033146)2.41443186
145monoubiquitinated protein deubiquitination (GO:0035520)2.41408100
146positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.40618985
147intracellular estrogen receptor signaling pathway (GO:0030520)2.40460136
148chondrocyte proliferation (GO:0035988)2.40397246
149mitotic nuclear envelope disassembly (GO:0007077)2.39924688
150anatomical structure regression (GO:0060033)2.39729528
151histone H3-K9 demethylation (GO:0033169)2.39330939
152detection of bacterium (GO:0016045)2.39189320
153negative regulation of mRNA metabolic process (GO:1903312)2.38737240
154DNA geometric change (GO:0032392)2.38517193
155trophectodermal cell differentiation (GO:0001829)2.37729334
156glomerular filtration (GO:0003094)2.36731216
157positive regulation of transcription regulatory region DNA binding (GO:2000679)2.36456773
158histone demethylation (GO:0016577)2.36203732
159mammary gland epithelial cell proliferation (GO:0033598)2.36130589
160regulation of nucleobase-containing compound transport (GO:0032239)2.35732659
161gastrulation with mouth forming second (GO:0001702)2.35290640
162positive regulation of Cdc42 GTPase activity (GO:0043089)2.35168040
163basic amino acid transport (GO:0015802)2.34501645
164cellular response to topologically incorrect protein (GO:0035967)2.34398690
165T cell selection (GO:0045058)2.33767753
166neuron projection extension involved in neuron projection guidance (GO:1902284)2.33463251
167axon extension involved in axon guidance (GO:0048846)2.33463251
168nuclear envelope disassembly (GO:0051081)2.33355734
169membrane disassembly (GO:0030397)2.33355734
170mannose metabolic process (GO:0006013)2.33172232
171response to laminar fluid shear stress (GO:0034616)2.31462204
172regulation of heart morphogenesis (GO:2000826)2.31284087
173positive regulation of epithelial to mesenchymal transition (GO:0010718)2.31122364
174protein export from nucleus (GO:0006611)2.31098332
175epithelial cell fate commitment (GO:0072148)2.31054198
176establishment of apical/basal cell polarity (GO:0035089)2.30701320
177vascular endothelial growth factor signaling pathway (GO:0038084)2.30130133
178macrophage activation (GO:0042116)2.30090302
179embryonic retina morphogenesis in camera-type eye (GO:0060059)2.29591177
180nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.29012607
181regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)2.28520184
182cellular response to growth hormone stimulus (GO:0071378)2.28377838
183endocardial cushion development (GO:0003197)2.28145089
184embryonic eye morphogenesis (GO:0048048)2.28104694
185T-helper cell differentiation (GO:0042093)2.28016669
186CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.28016669
187regulation of cardioblast proliferation (GO:0003264)2.27553996
188regulation of secondary heart field cardioblast proliferation (GO:0003266)2.27553996
189anterior/posterior axis specification, embryo (GO:0008595)2.26454218
190Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.25963421
191negative regulation of RNA splicing (GO:0033119)2.25758728
192regulation of transforming growth factor beta2 production (GO:0032909)2.25313541
193negative regulation of mRNA processing (GO:0050686)2.24581622
194genitalia morphogenesis (GO:0035112)2.24154924

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.62385554
2EGR1_19374776_ChIP-ChIP_THP-1_Human5.33524923
3NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse4.23864876
4FOXM1_23109430_ChIP-Seq_U2OS_Human3.23127437
5FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.12059861
6TP63_17297297_ChIP-ChIP_HaCaT_Human3.05265396
7RBPJ_22232070_ChIP-Seq_NCS_Mouse2.93225399
8MYC_22102868_ChIP-Seq_BL_Human2.85080002
9CLOCK_20551151_ChIP-Seq_293T_Human2.77475411
10SALL1_21062744_ChIP-ChIP_HESCs_Human2.72727170
11TP63_19390658_ChIP-ChIP_HaCaT_Human2.66185350
12STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.62980057
13KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.55131659
14TRIM28_21343339_ChIP-Seq_HEK293_Human2.12982933
15KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.11258466
16KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.11258466
17KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.11258466
18MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.10826634
19E2F4_17652178_ChIP-ChIP_JURKAT_Human2.09877593
20FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.06457887
21DMRT1_23473982_ChIP-Seq_TESTES_Mouse2.05490308
22TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.99494913
23HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.92443679
24GATA1_22025678_ChIP-Seq_K562_Human1.88434992
25ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.87228865
26* MYB_21317192_ChIP-Seq_ERMYB_Mouse1.86153867
27HIF1A_21447827_ChIP-Seq_MCF-7_Human1.86005631
28NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.84807830
29STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.82999450
30ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.81969284
31AR_21909140_ChIP-Seq_LNCAP_Human1.80898951
32E2F1_21310950_ChIP-Seq_MCF-7_Human1.80164581
33ESR2_21235772_ChIP-Seq_MCF-7_Human1.79279093
34* SPI1_23127762_ChIP-Seq_K562_Human1.75651757
35* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.73021282
36FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.72941952
37TCF7_22412390_ChIP-Seq_EML_Mouse1.72711810
38FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.71354940
39RUNX_20019798_ChIP-Seq_JUKART_Human1.71133584
40HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.69865546
41MYB_26560356_Chip-Seq_TH1_Human1.69403564
42SPI1_23547873_ChIP-Seq_NB4_Human1.68924338
43* PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.67316829
44TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.66451458
45KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.66409964
46DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.66153731
47KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.65519314
48* CHD1_26751641_Chip-Seq_LNCaP_Human1.63974520
49* BRD4_25478319_ChIP-Seq_HGPS_Human1.59110551
50* RUNX1_22412390_ChIP-Seq_EML_Mouse1.55140629
51SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.54966979
52PKCTHETA_26484144_Chip-Seq_BREAST_Human1.54537312
53VDR_24763502_ChIP-Seq_THP-1_Human1.54297270
54MAF_26560356_Chip-Seq_TH2_Human1.52898352
55SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.52445085
56* RACK7_27058665_Chip-Seq_MCF-7_Human1.52129123
57BRD4_27068464_Chip-Seq_AML-cells_Mouse1.51481592
58E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.51388245
59* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.51254609
60SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.50591091
61* ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.50053486
62* MYB_26560356_Chip-Seq_TH2_Human1.49422259
63IRF8_21731497_ChIP-ChIP_J774_Mouse1.44448914
64KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.41306003
65* FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.40991942
66SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.40799807
67* KDM2B_26808549_Chip-Seq_DND41_Human1.40455649
68IRF8_27001747_Chip-Seq_BMDM_Mouse1.39891385
69FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.38773003
70KDM5A_27292631_Chip-Seq_BREAST_Human1.37692221
71* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.37649436
72* WT1_19549856_ChIP-ChIP_CCG9911_Human1.36993139
73P300_27058665_Chip-Seq_ZR-75-30cells_Human1.36565597
74* RUNX1_27514584_Chip-Seq_MCF-7_Human1.36438015
75CIITA_25753668_ChIP-Seq_RAJI_Human1.35876778
76* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.35377712
77CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.33751009
78NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.33606004
79IRF8_22096565_ChIP-ChIP_GC-B_Human1.33434468
80ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.32424491
81CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.31462005
82* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.29184404
83ESR1_15608294_ChIP-ChIP_MCF-7_Human1.29056290
84LXR_22158963_ChIP-Seq_LIVER_Mouse1.28881534
85SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.28031625
86* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.27408208
87E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.26831802
88* FOXA2_19822575_ChIP-Seq_HepG2_Human1.26251643
89* ISL1_27105846_Chip-Seq_CPCs_Mouse1.25000262
90SCL_19346495_ChIP-Seq_HPC-7_Human1.24922943
91FOXO3_23340844_ChIP-Seq_DLD1_Human1.24433836
92NFIB_24661679_ChIP-Seq_LUNG_Mouse1.24408898
93* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.23963390
94VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.23930632
95ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.21540248
96STAT6_21828071_ChIP-Seq_BEAS2B_Human1.21083856
97NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.20607356
98ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.19218845
99NOTCH1_21737748_ChIP-Seq_TLL_Human1.19151787
100IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.18677983
101PPARA_22158963_ChIP-Seq_LIVER_Mouse1.18446408
102ELK3_25401928_ChIP-Seq_HUVEC_Human1.17867890
103UBF1/2_26484160_Chip-Seq_HMECs_Human1.17819965
104* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.17638774
105KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.17396354
106TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.16716589
107NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.16159137
108NANOG_21062744_ChIP-ChIP_HESCs_Human1.15156457
109KDM2B_26808549_Chip-Seq_JURKAT_Human1.15074737
110SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.14333245
111SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.14333245
112PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.14064282
113BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.13723175
114* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.12840205
115MYC_18555785_ChIP-Seq_MESCs_Mouse1.11850750
116VDR_21846776_ChIP-Seq_THP-1_Human1.10846683
117ZFX_18555785_ChIP-Seq_MESCs_Mouse1.10250694
118CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.09952271
119ERG_20887958_ChIP-Seq_HPC-7_Mouse1.09685295
120* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.09158594
121* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.07475405
122* TCF3_18692474_ChIP-Seq_MEFs_Mouse1.07264465
123NCOR1_26117541_ChIP-Seq_K562_Human1.06897713
124SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.06644261
125TFEB_21752829_ChIP-Seq_HELA_Human1.06312012
126TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.05284905
127ZNF217_24962896_ChIP-Seq_MCF-7_Human1.05198311
128FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.04769684
129AHR_22903824_ChIP-Seq_MCF-7_Human1.04700804
130* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.04684420
131TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.04244437
132* GATA6_25053715_ChIP-Seq_YYC3_Human1.04158701
133ESR1_20079471_ChIP-ChIP_T-47D_Human1.02904131
134* SALL4_18804426_ChIP-ChIP_XEN_Mouse1.01885781
135UTX_26944678_Chip-Seq_JUKART_Human1.01213033
136* RXR_22158963_ChIP-Seq_LIVER_Mouse1.01209190
137PADI4_21655091_ChIP-ChIP_MCF-7_Human1.00800564
138* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.00664071
139PU_27001747_Chip-Seq_BMDM_Mouse1.00311148
140TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.99923953
141ESR1_21235772_ChIP-Seq_MCF-7_Human0.98889051
142NELFA_20434984_ChIP-Seq_ESCs_Mouse0.98664743
143ARNT_22903824_ChIP-Seq_MCF-7_Human0.98113637
144CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.97900713
145TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.97484113
146KDM2B_26808549_Chip-Seq_SUP-B15_Human0.96603586
147RARG_19884340_ChIP-ChIP_MEFs_Mouse0.96304165
148POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.93281273
149SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.92083289
150STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.91490060
151FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.91476949
152* ATF3_27146783_Chip-Seq_COLON_Human0.90196190
153SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.89921864
154MAF_26560356_Chip-Seq_TH1_Human0.89710210
155SOX9_24532713_ChIP-Seq_HFSC_Mouse0.89229049
156EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.88922705

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003705_abnormal_hypodermis_morpholog2.99856914
2MP0004381_abnormal_hair_follicle2.82067752
3MP0010352_gastrointestinal_tract_polyps2.60445178
4MP0003172_abnormal_lysosome_physiology2.50808542
5MP0005076_abnormal_cell_differentiation2.49696793
6MP0002877_abnormal_melanocyte_morpholog2.49340872
7MP0005408_hypopigmentation2.43984493
8MP0003123_paternal_imprinting2.41677472
9MP0003724_increased_susceptibility_to2.39727240
10MP0006054_spinal_hemorrhage2.38668029
11MP0003436_decreased_susceptibility_to2.34340356
12MP0003300_gastrointestinal_ulcer2.29531515
13MP0003122_maternal_imprinting2.27388234
14MP0008438_abnormal_cutaneous_collagen2.22163172
15MP0005075_abnormal_melanosome_morpholog2.17685828
16MP0010030_abnormal_orbit_morphology2.10936420
17MP0003121_genomic_imprinting2.01505170
18MP0005451_abnormal_body_composition1.97665577
19MP0003763_abnormal_thymus_physiology1.96125621
20MP0002254_reproductive_system_inflammat1.95785306
21MP0000537_abnormal_urethra_morphology1.95078899
22MP0009053_abnormal_anal_canal1.93025244
23MP0005503_abnormal_tendon_morphology1.82591914
24MP0000569_abnormal_digit_pigmentation1.79786754
25MP0001873_stomach_inflammation1.79619895
26MP0003878_abnormal_ear_physiology1.78754171
27MP0005377_hearing/vestibular/ear_phenot1.78754171
28MP0002277_abnormal_respiratory_mucosa1.77572992
29MP0004272_abnormal_basement_membrane1.74809326
30MP0003283_abnormal_digestive_organ1.69452061
31MP0003942_abnormal_urinary_system1.66513202
32MP0004197_abnormal_fetal_growth/weight/1.66025153
33MP0002132_abnormal_respiratory_system1.62735878
34MP0010234_abnormal_vibrissa_follicle1.60234021
35MP0000371_diluted_coat_color1.59692161
36MP0003566_abnormal_cell_adhesion1.58796176
37MP0000703_abnormal_thymus_morphology1.56637434
38MP0003115_abnormal_respiratory_system1.52762123
39MP0009703_decreased_birth_body1.49711440
40MP0000013_abnormal_adipose_tissue1.49027661
41MP0000428_abnormal_craniofacial_morphol1.48658301
42MP0002896_abnormal_bone_mineralization1.47007067
43MP0005174_abnormal_tail_pigmentation1.45896603
44MP0009780_abnormal_chondrocyte_physiolo1.45735706
45MP0003567_abnormal_fetal_cardiomyocyte1.45657221
46MP0003943_abnormal_hepatobiliary_system1.44841859
47MP0009384_cardiac_valve_regurgitation1.44820379
48MP0005275_abnormal_skin_tensile1.41726344
49MP0000003_abnormal_adipose_tissue1.41703123
50MP0002396_abnormal_hematopoietic_system1.41282416
51MP0003935_abnormal_craniofacial_develop1.40720956
52MP0003890_abnormal_embryonic-extraembry1.39296956
53MP0003279_aneurysm1.38774863
54MP0001879_abnormal_lymphatic_vessel1.36695753
55MP0005248_abnormal_Harderian_gland1.36665445
56MP0001293_anophthalmia1.36335098
57MP0009672_abnormal_birth_weight1.35656398
58MP0003385_abnormal_body_wall1.35364723
59MP0005187_abnormal_penis_morphology1.33936812
60MP0004264_abnormal_extraembryonic_tissu1.32705338
61MP0002084_abnormal_developmental_patter1.32569479
62MP0004808_abnormal_hematopoietic_stem1.32026634
63MP0006292_abnormal_olfactory_placode1.31757557
64MP0000685_abnormal_immune_system1.31318179
65MP0002086_abnormal_extraembryonic_tissu1.29202100
66MP0000733_abnormal_muscle_development1.28056177
67MP0000015_abnormal_ear_pigmentation1.28003451
68MP0010368_abnormal_lymphatic_system1.27855192
69MP0005310_abnormal_salivary_gland1.27244654
70MP0000566_synostosis1.26928640
71MP0002088_abnormal_embryonic_growth/wei1.23279518
72MP0003938_abnormal_ear_development1.22335560
73MP0003984_embryonic_growth_retardation1.22039400
74MP0002909_abnormal_adrenal_gland1.21314283
75MP0002405_respiratory_system_inflammati1.19901488
76MP0005508_abnormal_skeleton_morphology1.18116047
77MP0005380_embryogenesis_phenotype1.17313253
78MP0001672_abnormal_embryogenesis/_devel1.17313253
79MP0000350_abnormal_cell_proliferation1.16247447
80MP0010307_abnormal_tumor_latency1.16065655
81MP0008877_abnormal_DNA_methylation1.15730162
82MP0000534_abnormal_ureter_morphology1.15422812
83MP0002419_abnormal_innate_immunity1.14394978
84MP0003119_abnormal_digestive_system1.14304514
85MP0002398_abnormal_bone_marrow1.14259605
86MP0004233_abnormal_muscle_weight1.14157295
87MP0005023_abnormal_wound_healing1.12847240
88MP0002925_abnormal_cardiovascular_devel1.12469731
89MP0001299_abnormal_eye_distance/1.11831980
90MP0001944_abnormal_pancreas_morphology1.10705109
91MP0005220_abnormal_exocrine_pancreas1.10337486
92MP0001697_abnormal_embryo_size1.09341262
93MP0002085_abnormal_embryonic_tissue1.08956294
94MP0002932_abnormal_joint_morphology1.08514080
95MP0005367_renal/urinary_system_phenotyp1.08014844
96MP0000516_abnormal_urinary_system1.08014844
97MP0001346_abnormal_lacrimal_gland1.07961081
98MP0003937_abnormal_limbs/digits/tail_de1.07347901
99MP0001533_abnormal_skeleton_physiology1.07250568
100MP0004957_abnormal_blastocyst_morpholog1.06667949
101MP0001730_embryonic_growth_arrest1.06244930
102MP0001849_ear_inflammation1.06177565
103MP0000432_abnormal_head_morphology1.05301822
104MP0001915_intracranial_hemorrhage1.04970005
105MP0008007_abnormal_cellular_replicative1.04822064
106MP0003941_abnormal_skin_development1.04735459
107MP0004883_abnormal_blood_vessel1.04587672
108MP0001800_abnormal_humoral_immune1.04427951
109MP0003091_abnormal_cell_migration1.03889723
110MP0001186_pigmentation_phenotype1.03814500
111MP0002166_altered_tumor_susceptibility1.01997635
112MP0003303_peritoneal_inflammation1.01916714
113MP0003111_abnormal_nucleus_morphology0.99049320
114MP0002092_abnormal_eye_morphology0.99009723
115MP0005464_abnormal_platelet_physiology0.98964706
116MP0002697_abnormal_eye_size0.97506873
117MP0002723_abnormal_immune_serum0.96692191
118MP0002420_abnormal_adaptive_immunity0.96031036
119MP0005025_abnormal_response_to0.95887748
120MP0001819_abnormal_immune_cell0.95624123
121MP0009250_abnormal_appendicular_skeleto0.94808076
122MP0008057_abnormal_DNA_replication0.94117650
123MP0003755_abnormal_palate_morphology0.93980565
124MP0009333_abnormal_splenocyte_physiolog0.93825402
125MP0005375_adipose_tissue_phenotype0.93131866
126MP0002938_white_spotting0.92761812
127MP0008260_abnormal_autophagy0.92495377
128MP0002009_preneoplasia0.92329726
129MP0002075_abnormal_coat/hair_pigmentati0.92204031
130MP0001270_distended_abdomen0.91872909
131MP0008961_abnormal_basal_metabolism0.91740290
132MP0005623_abnormal_meninges_morphology0.91670494
133MP0000678_abnormal_parathyroid_gland0.91579473
134MP0004858_abnormal_nervous_system0.91034054
135MP0000266_abnormal_heart_morphology0.90441556
136MP0000163_abnormal_cartilage_morphology0.89700440
137MP0002116_abnormal_craniofacial_bone0.89675139
138MP0003077_abnormal_cell_cycle0.88814179
139MP0000049_abnormal_middle_ear0.88237439
140MP0002722_abnormal_immune_system0.87998765
141MP0002928_abnormal_bile_duct0.87248620
142MP0009278_abnormal_bone_marrow0.87161140
143MP0000470_abnormal_stomach_morphology0.87040365
144MP0000490_abnormal_crypts_of0.86927301
145MP0002138_abnormal_hepatobiliary_system0.86926872
146MP0002234_abnormal_pharynx_morphology0.86820120
147MP0005000_abnormal_immune_tolerance0.86199562
148MP0002080_prenatal_lethality0.86158677
149MP0002111_abnormal_tail_morphology0.85688776
150MP0002168_other_aberrant_phenotype0.85393774
151MP0000716_abnormal_immune_system0.84921788
152MP0002693_abnormal_pancreas_physiology0.83563177
153MP0000689_abnormal_spleen_morphology0.83437909
154MP0002089_abnormal_postnatal_growth/wei0.82748317
155MP0003656_abnormal_erythrocyte_physiolo0.82075909
156MP0001835_abnormal_antigen_presentation0.81556365
157MP0000427_abnormal_hair_cycle0.80603978
158MP0003191_abnormal_cellular_cholesterol0.79069040
159MP0003936_abnormal_reproductive_system0.76410308

Predicted human phenotypes

RankGene SetZ-score
1Stomatitis (HP:0010280)3.96116355
2Orchitis (HP:0100796)3.61736440
3Short 4th metacarpal (HP:0010044)3.49105745
4Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.49105745
5Optic neuritis (HP:0100653)3.39790266
6Retrobulbar optic neuritis (HP:0100654)3.39790266
7Eczematoid dermatitis (HP:0000976)3.35426109
8Volvulus (HP:0002580)3.34151237
9Myositis (HP:0100614)3.25146706
10Protrusio acetabuli (HP:0003179)3.19639916
11Macroorchidism (HP:0000053)3.11674722
12Hematochezia (HP:0002573)2.99956952
13Syringomyelia (HP:0003396)2.99566457
14Spinal cord lesions (HP:0100561)2.99566457
15Shallow orbits (HP:0000586)2.87817915
16Gastrointestinal infarctions (HP:0005244)2.85986137
17Recurrent gram-negative bacterial infections (HP:0005420)2.83770827
18Abnormality of macrophages (HP:0004311)2.79884032
19Abnormality of the 4th metacarpal (HP:0010012)2.78651747
20Aortic aneurysm (HP:0004942)2.76014391
21Recurrent abscess formation (HP:0002722)2.75973203
22Hypochromic microcytic anemia (HP:0004840)2.70243253
23Rectal prolapse (HP:0002035)2.65316747
24Renal duplication (HP:0000075)2.65300494
25Peritonitis (HP:0002586)2.65228096
26Aqueductal stenosis (HP:0002410)2.61361472
27Cerebral aneurysm (HP:0004944)2.59981716
28Subacute progressive viral hepatitis (HP:0006572)2.56255549
29Broad thumb (HP:0011304)2.53760479
30Recurrent bacterial skin infections (HP:0005406)2.53387058
31Ankle contracture (HP:0006466)2.51006649
32Long eyelashes (HP:0000527)2.49635914
33Abnormality of the aortic arch (HP:0012303)2.47554982
34Colon cancer (HP:0003003)2.46545717
35Hypoplastic labia majora (HP:0000059)2.45414845
36Narrow palate (HP:0000189)2.41403341
37Testicular neoplasm (HP:0010788)2.38526400
38Recurrent cutaneous fungal infections (HP:0011370)2.36602045
39Chronic mucocutaneous candidiasis (HP:0002728)2.36602045
40Recurrent fungal infections (HP:0002841)2.32685193
41Hypochromic anemia (HP:0001931)2.26645013
42Abnormality of incisor morphology (HP:0011063)2.24421095
43Abnormality of the distal phalanx of the thumb (HP:0009617)2.24215712
44Spondylolisthesis (HP:0003302)2.24198479
45Mitral valve prolapse (HP:0001634)2.23613247
46Increased nuchal translucency (HP:0010880)2.21869814
47Deviation of the thumb (HP:0009603)2.20322478
48Abnormality of the common coagulation pathway (HP:0010990)2.20097055
49Elevated erythrocyte sedimentation rate (HP:0003565)2.18448622
50Absent frontal sinuses (HP:0002688)2.18224535
51Abnormality of the fingertips (HP:0001211)2.17698843
52Aneurysm (HP:0002617)2.17162076
53Ankyloglossia (HP:0010296)2.15683823
54Hepatoblastoma (HP:0002884)2.14059744
55Abnormality of the labia majora (HP:0012881)2.13839288
56Truncal obesity (HP:0001956)2.12191596
57Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.11946256
58Arterial thrombosis (HP:0004420)2.11326924
59T lymphocytopenia (HP:0005403)2.08032725
60Deep venous thrombosis (HP:0002625)2.07314730
61Osteomalacia (HP:0002749)2.07179694
62Broad phalanges of the hand (HP:0009768)2.06626831
63Cervical subluxation (HP:0003308)2.06378387
64Proximal placement of thumb (HP:0009623)2.05697466
65Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.04657591
66Asymmetry of the thorax (HP:0001555)2.04210458
67Abnormal delayed hypersensitivity skin test (HP:0002963)2.04162281
68Bowel diverticulosis (HP:0005222)2.04110506
69Recurrent skin infections (HP:0001581)2.02604273
70Broad palm (HP:0001169)2.02270511
71Thin bony cortex (HP:0002753)2.02234021
72Dilatation of the ascending aorta (HP:0005111)2.01923298
73Abnormality of oral frenula (HP:0000190)2.01788770
74Episodic fever (HP:0001954)2.01293072
75Flat acetabular roof (HP:0003180)1.99752470
76Short middle phalanx of the 5th finger (HP:0004220)1.98562675
77Metaphyseal cupping (HP:0003021)1.97892373
78Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.97579779
79Microglossia (HP:0000171)1.96902329
80Biliary tract neoplasm (HP:0100574)1.96272128
81Bladder diverticulum (HP:0000015)1.95507311
82Missing ribs (HP:0000921)1.94847544
83Short 5th finger (HP:0009237)1.94772464
84Broad phalanx (HP:0006009)1.94329811
85Broad finger (HP:0001500)1.94152358
86Overlapping toe (HP:0001845)1.94099707
87Broad long bones (HP:0005622)1.93727435
88Exostoses (HP:0100777)1.91291410
89Disproportionate tall stature (HP:0001519)1.90817531
90Keratoconjunctivitis (HP:0001096)1.90737699
91Abnormal vertebral ossification (HP:0100569)1.90707633
92Gastrointestinal carcinoma (HP:0002672)1.90136317
93Malignant gastrointestinal tract tumors (HP:0006749)1.90136317
94Enlarged penis (HP:0000040)1.90120245
95Septate vagina (HP:0001153)1.89785567
96Hyperglycemia (HP:0003074)1.89773076
97Abnormality of the nasal septum (HP:0000419)1.89618320
98Gingival bleeding (HP:0000225)1.88607260
99Hyperacusis (HP:0010780)1.88185713
100Lymphangioma (HP:0100764)1.87875413
101Mesomelia (HP:0003027)1.86767744
102Transitional cell carcinoma of the bladder (HP:0006740)1.86002856
103Thick eyebrow (HP:0000574)1.85181776
104Keratoconjunctivitis sicca (HP:0001097)1.84996327
105Urethral obstruction (HP:0000796)1.84479535
106Increased density of long bones (HP:0006392)1.83892374
107Pancreatic islet-cell hyperplasia (HP:0004510)1.83821503
108Increased number of teeth (HP:0011069)1.83510490
109Curly hair (HP:0002212)1.82864055
110Deep philtrum (HP:0002002)1.82422502
111Hypoplasia of the maxilla (HP:0000327)1.82309121
112Premature rupture of membranes (HP:0001788)1.82276365
113Nephroblastoma (Wilms tumor) (HP:0002667)1.81999882
114Deep palmar crease (HP:0006191)1.81901249
115Abnormality of the parietal bone (HP:0002696)1.81693666
116Anorexia (HP:0002039)1.81446165
117Aortic dissection (HP:0002647)1.81053227
118Hyperinsulinemic hypoglycemia (HP:0000825)1.80596568
119Anal stenosis (HP:0002025)1.79926731
120Abnormality of the phalanges of the hallux (HP:0010057)1.78548173
121Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.78346064
122Encephalitis (HP:0002383)1.78108072
123Hypoglycemic seizures (HP:0002173)1.78026126
124Abnormality of the distal phalanges of the toes (HP:0010182)1.77810177
125Deviation of the hallux (HP:0010051)1.77717153
126Camptodactyly of toe (HP:0001836)1.77011721
127Oligodactyly (HP:0012165)1.76474587
128Selective tooth agenesis (HP:0001592)1.75225907
129Renal cell carcinoma (HP:0005584)1.74641379
130Hallux valgus (HP:0001822)1.74407112
131Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.73815071
132Abnormality of the frontal sinuses (HP:0002687)1.72931821
133Bladder carcinoma (HP:0002862)1.71612606
134Bladder neoplasm (HP:0009725)1.71612606
135Broad metatarsal (HP:0001783)1.70164187
136Micronodular cirrhosis (HP:0001413)1.69512912
137Intestinal polyposis (HP:0200008)1.69405100
138Obsessive-compulsive behavior (HP:0000722)1.69380323
139Dislocated radial head (HP:0003083)1.69348461
140Abnormality of the right ventricle (HP:0001707)1.69295717
141Vascular calcification (HP:0004934)1.68391439
142Trigonocephaly (HP:0000243)1.68083538
143Papillary thyroid carcinoma (HP:0002895)1.67834483
144Low anterior hairline (HP:0000294)1.67053502
145Smooth philtrum (HP:0000319)1.67031872
146Intestinal polyp (HP:0005266)1.65897801
147Obstructive sleep apnea (HP:0002870)1.65746242
148Abnormal foot bone ossification (HP:0010675)1.65136775
149Prominent occiput (HP:0000269)1.65080345
150Diastasis recti (HP:0001540)1.65043992
151Abnormality of the radial head (HP:0003995)1.64199126
152Broad toe (HP:0001837)1.63829138
153Uterine leiomyosarcoma (HP:0002891)1.63770684
154Leiomyosarcoma (HP:0100243)1.63770684
155Supernumerary ribs (HP:0005815)1.63591055
156Joint laxity (HP:0001388)1.63547748
157Buphthalmos (HP:0000557)1.62687228
158Prolonged bleeding time (HP:0003010)1.62138772
159Astrocytoma (HP:0009592)1.61932382
160Abnormality of the astrocytes (HP:0100707)1.61932382
161Long palpebral fissure (HP:0000637)1.60955883
162Abnormality of the pancreatic islet cells (HP:0006476)1.60818645
163Abnormality of endocrine pancreas physiology (HP:0012093)1.60818645
164Uterine neoplasm (HP:0010784)1.60693360
165Skin tags (HP:0010609)1.60260409
166Ependymoma (HP:0002888)1.59762335
167Embryonal renal neoplasm (HP:0011794)1.59033328
168Acne (HP:0001061)1.58978255
169Bicuspid aortic valve (HP:0001647)1.58862151
170Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.58768921
171Wide nose (HP:0000445)1.58083996
172Atrophic scars (HP:0001075)1.57917177
173Abnormality of T cell number (HP:0011839)1.57207959
174Heterotopia (HP:0002282)1.53150607
175Spontaneous hematomas (HP:0007420)1.52949287
176Albinism (HP:0001022)1.52143939
177Ectopic kidney (HP:0000086)1.49355535

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK123.99543632
2TRIB33.63351614
3PKN22.78434249
4SMG12.74094037
5LATS12.73873670
6MAP3K102.67452576
7PASK2.53453046
8RIPK42.53308648
9IRAK42.35385649
10FLT32.35116505
11SIK12.31349294
12PDGFRA2.25313221
13FRK2.03628637
14CDC72.03563186
15PTK61.97004324
16EEF2K1.93645736
17BRD41.84867163
18TGFBR11.82985505
19ERN11.79721565
20CAMK1D1.76124310
21FGFR31.75495884
22MAP4K11.72320438
23TNK21.71355835
24EPHB11.70751569
25PRPF4B1.69497786
26INSRR1.68060127
27SCYL21.67528824
28SIK31.65869586
29LRRK21.65380183
30YES11.64822600
31STK101.63894592
32CSK1.62315010
33CDK61.54872591
34EPHA31.52564787
35MTOR1.49813121
36RPS6KA41.46271625
37GRK61.44182392
38PRKD21.42098975
39PRKD31.40031121
40FGFR11.39052598
41CAMK1G1.35906971
42TTN1.31667781
43EPHB21.19971202
44PAK21.18878831
45BRSK21.17097688
46JAK31.15975790
47RIPK11.15141577
48HIPK21.13693568
49NEK91.12616213
50KSR21.11826899
51TAOK11.11282784
52STK31.10746387
53FGFR21.10318412
54ICK1.10208623
55DDR21.06991763
56IRAK11.06648641
57PDGFRB0.99799256
58FGFR40.96502930
59AKT30.96499430
60CHUK0.95801877
61IRAK30.95184000
62TGFBR20.94705552
63KSR10.94425599
64HCK0.93346729
65ALK0.92579290
66IRAK20.91390379
67FGR0.91248521
68ERBB30.89159214
69MAP3K10.89053953
70MKNK10.87796365
71PDPK10.87631631
72PDK10.86865622
73PTK20.85289554
74MAP3K140.84414449
75SGK20.83815835
76JAK10.79899856
77DYRK1B0.79841475
78BTK0.79612879
79TAOK30.78853465
80RPS6KB20.78738277
81DMPK0.78486710
82CDK90.78243281
83MAP3K80.77879709
84TYRO30.75480918
85STK380.75181834
86TAOK20.74641906
87ATR0.74526725
88MARK30.73860590
89RET0.72612247
90DYRK30.71891383
91CDK70.71834420
92MARK20.71776902
93CDK40.71695056
94CLK10.70912742
95RPS6KL10.70800798
96RPS6KC10.70800798
97PAK40.69518747
98TAF10.68710081
99BLK0.68508984
100TXK0.67361276
101TYK20.66201486
102NEK20.65612093
103STK110.65546810
104ATM0.64689085
105EIF2AK10.64626347
106MAPKAPK20.64322411
107MAP3K130.64285368
108MAP3K20.64266011
109IKBKE0.64209921
110MELK0.63833164
111RAF10.63593808
112PIK3CA0.63360163
113WNK40.62995680
114CHEK10.62140491
115RPS6KA60.60476935
116PRKCH0.60012079
117PAK30.56165107
118FER0.55372955
119CDC42BPA0.55001432
120MAP3K120.54885232
121PLK30.53733771
122NEK60.53475686
123JAK20.53333928
124PIK3CG0.52135490
125ERBB20.51606228
126MET0.51174374
127CDK20.51090830
128MAP3K30.49900774
129MAP3K70.49481519
130MAP2K20.48605548
131AURKB0.46962320
132MAPK10.46466773
133EPHA20.45290008
134MAPK140.44664482
135WNK10.43437876
136AKT10.42710848
137PRKDC0.42142770
138STK40.41248168
139RPS6KB10.40588674
140NUAK10.40104119
141NLK0.40059061
142IGF1R0.38962683
143LATS20.38886853
144ITK0.37930150
145SGK30.37483336
146MAP2K30.35885237
147INSR0.34937506
148CDK10.34111177
149ZAP700.33773780
150CSNK1A1L0.32909120
151BMX0.32106553
152CDK80.31463261
153MKNK20.31197733
154MAPK30.30443002

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049502.19624361
2Adherens junction_Homo sapiens_hsa045202.05953936
3Fc epsilon RI signaling pathway_Homo sapiens_hsa046642.00088430
4Chronic myeloid leukemia_Homo sapiens_hsa052201.99484148
5Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.89580781
6Lysine degradation_Homo sapiens_hsa003101.79945436
7Small cell lung cancer_Homo sapiens_hsa052221.77272669
8MicroRNAs in cancer_Homo sapiens_hsa052061.76026105
9Proteoglycans in cancer_Homo sapiens_hsa052051.67816401
10Basal cell carcinoma_Homo sapiens_hsa052171.62651416
11Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.58867870
12Colorectal cancer_Homo sapiens_hsa052101.58112396
13mTOR signaling pathway_Homo sapiens_hsa041501.57635410
14Thyroid cancer_Homo sapiens_hsa052161.56239756
15Endometrial cancer_Homo sapiens_hsa052131.55571725
16Hippo signaling pathway_Homo sapiens_hsa043901.53195078
17Prostate cancer_Homo sapiens_hsa052151.52592025
18Focal adhesion_Homo sapiens_hsa045101.52570465
19Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.49833067
20Insulin resistance_Homo sapiens_hsa049311.48342518
21Cell cycle_Homo sapiens_hsa041101.46796132
22Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.45857951
23Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.43339466
24Choline metabolism in cancer_Homo sapiens_hsa052311.43206969
25Type II diabetes mellitus_Homo sapiens_hsa049301.37892634
26Hepatitis C_Homo sapiens_hsa051601.35482935
27Pancreatic cancer_Homo sapiens_hsa052121.34682454
28Inositol phosphate metabolism_Homo sapiens_hsa005621.32630497
29TGF-beta signaling pathway_Homo sapiens_hsa043501.31259490
30HTLV-I infection_Homo sapiens_hsa051661.31185554
31ECM-receptor interaction_Homo sapiens_hsa045121.31103560
32AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.26467606
33Neurotrophin signaling pathway_Homo sapiens_hsa047221.25665959
34Thyroid hormone signaling pathway_Homo sapiens_hsa049191.25476339
35Chemokine signaling pathway_Homo sapiens_hsa040621.24833706
36Acute myeloid leukemia_Homo sapiens_hsa052211.24642575
37Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.23350746
38ErbB signaling pathway_Homo sapiens_hsa040121.20273428
39Central carbon metabolism in cancer_Homo sapiens_hsa052301.19259419
40Transcriptional misregulation in cancer_Homo sapiens_hsa052021.18834238
41Hedgehog signaling pathway_Homo sapiens_hsa043401.17846867
42Viral carcinogenesis_Homo sapiens_hsa052031.16389749
43Non-small cell lung cancer_Homo sapiens_hsa052231.15895871
44Toxoplasmosis_Homo sapiens_hsa051451.15078881
45Bladder cancer_Homo sapiens_hsa052191.14908163
46Toll-like receptor signaling pathway_Homo sapiens_hsa046201.13785146
47Prolactin signaling pathway_Homo sapiens_hsa049171.12251611
48Viral myocarditis_Homo sapiens_hsa054161.12187850
49Glioma_Homo sapiens_hsa052141.10399764
50Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.10327941
51Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.09054697
52Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.08580924
53Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.07826896
54Longevity regulating pathway - mammal_Homo sapiens_hsa042111.06666432
55mRNA surveillance pathway_Homo sapiens_hsa030151.05933783
56Pathways in cancer_Homo sapiens_hsa052001.05508957
57Leukocyte transendothelial migration_Homo sapiens_hsa046701.05460697
58Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.02560302
59AMPK signaling pathway_Homo sapiens_hsa041520.99890571
60Hepatitis B_Homo sapiens_hsa051610.99576439
61One carbon pool by folate_Homo sapiens_hsa006700.99458534
62Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.98908054
63Phosphatidylinositol signaling system_Homo sapiens_hsa040700.98447788
64Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.95971580
65FoxO signaling pathway_Homo sapiens_hsa040680.95822895
66RNA transport_Homo sapiens_hsa030130.95566665
67* Wnt signaling pathway_Homo sapiens_hsa043100.94687752
68Insulin signaling pathway_Homo sapiens_hsa049100.93942201
69Antigen processing and presentation_Homo sapiens_hsa046120.93153487
70Amoebiasis_Homo sapiens_hsa051460.92298064
71Notch signaling pathway_Homo sapiens_hsa043300.91363660
72Sphingolipid signaling pathway_Homo sapiens_hsa040710.90972998
73Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.89649766
74PI3K-Akt signaling pathway_Homo sapiens_hsa041510.89477602
75N-Glycan biosynthesis_Homo sapiens_hsa005100.89179191
76Glucagon signaling pathway_Homo sapiens_hsa049220.87026375
77Renal cell carcinoma_Homo sapiens_hsa052110.86650549
78Estrogen signaling pathway_Homo sapiens_hsa049150.83991383
79Melanoma_Homo sapiens_hsa052180.83414321
80p53 signaling pathway_Homo sapiens_hsa041150.82640649
81Legionellosis_Homo sapiens_hsa051340.81947137
82Platelet activation_Homo sapiens_hsa046110.79775824
83Other glycan degradation_Homo sapiens_hsa005110.78078287
84Tight junction_Homo sapiens_hsa045300.78018851
85Selenocompound metabolism_Homo sapiens_hsa004500.76236439
86Protein digestion and absorption_Homo sapiens_hsa049740.75626242
87Phospholipase D signaling pathway_Homo sapiens_hsa040720.74488087
88TNF signaling pathway_Homo sapiens_hsa046680.74472636
89NOD-like receptor signaling pathway_Homo sapiens_hsa046210.73683365
90Melanogenesis_Homo sapiens_hsa049160.73249147
91Influenza A_Homo sapiens_hsa051640.71261535
92Adipocytokine signaling pathway_Homo sapiens_hsa049200.69613596
93Non-homologous end-joining_Homo sapiens_hsa034500.69520202
94Herpes simplex infection_Homo sapiens_hsa051680.68336861
95Thyroid hormone synthesis_Homo sapiens_hsa049180.67211445
96Carbohydrate digestion and absorption_Homo sapiens_hsa049730.67035314
97T cell receptor signaling pathway_Homo sapiens_hsa046600.66069662
98Dilated cardiomyopathy_Homo sapiens_hsa054140.65845986
99Tuberculosis_Homo sapiens_hsa051520.65058676
100B cell receptor signaling pathway_Homo sapiens_hsa046620.64158847
101Mismatch repair_Homo sapiens_hsa034300.63813361
102HIF-1 signaling pathway_Homo sapiens_hsa040660.63298948
103Rap1 signaling pathway_Homo sapiens_hsa040150.62932911
104Vitamin digestion and absorption_Homo sapiens_hsa049770.62185187
105Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.60568128
106Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.60067733
107Dorso-ventral axis formation_Homo sapiens_hsa043200.59870221
108Nitrogen metabolism_Homo sapiens_hsa009100.59797600
109Measles_Homo sapiens_hsa051620.59678986
110GnRH signaling pathway_Homo sapiens_hsa049120.59156093
111Regulation of actin cytoskeleton_Homo sapiens_hsa048100.59127970
112Jak-STAT signaling pathway_Homo sapiens_hsa046300.58742547
113Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.58636542
114Primary immunodeficiency_Homo sapiens_hsa053400.58538757
115VEGF signaling pathway_Homo sapiens_hsa043700.56602956
116Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.55745194
117Apoptosis_Homo sapiens_hsa042100.55713693
118Renin-angiotensin system_Homo sapiens_hsa046140.55271594
119cGMP-PKG signaling pathway_Homo sapiens_hsa040220.54961416
120Epstein-Barr virus infection_Homo sapiens_hsa051690.54717763
121Complement and coagulation cascades_Homo sapiens_hsa046100.54463487
122MAPK signaling pathway_Homo sapiens_hsa040100.53588229
123Osteoclast differentiation_Homo sapiens_hsa043800.52410850
124Insulin secretion_Homo sapiens_hsa049110.51882525
125NF-kappa B signaling pathway_Homo sapiens_hsa040640.51366578
126Leishmaniasis_Homo sapiens_hsa051400.51213427
127Shigellosis_Homo sapiens_hsa051310.51180136
128Basal transcription factors_Homo sapiens_hsa030220.50159699
129Endocytosis_Homo sapiens_hsa041440.48279599

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