TBKBP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: TBKBP1 is an adaptor protein that binds to TBK1 (MIM 604834) and is part of the interaction network in the TNF (MIM 191160)/NFKB (see MIM 164011) pathway (Bouwmeester et al., 2004 [PubMed 14743216]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1doxorubicin metabolic process (GO:0044598)7.33599592
2daunorubicin metabolic process (GO:0044597)7.33599592
3polyketide metabolic process (GO:0030638)7.33599592
4synaptic vesicle maturation (GO:0016188)5.90456378
5maintenance of protein location in nucleus (GO:0051457)5.31236624
6proline transport (GO:0015824)5.26986704
7regulation of mammary gland epithelial cell proliferation (GO:0033599)4.84159502
8negative regulation of telomerase activity (GO:0051974)4.75912340
9negative regulation of erythrocyte differentiation (GO:0045647)4.60907265
10aminoglycoside antibiotic metabolic process (GO:0030647)4.46550192
11regulation of response to osmotic stress (GO:0047484)4.43079434
12histone H4-K8 acetylation (GO:0043982)4.42273230
13histone H4-K5 acetylation (GO:0043981)4.42273230
14negative regulation of cell killing (GO:0031342)4.41650744
15negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.41650744
16negative regulation of phagocytosis (GO:0050765)4.33113701
17histone H4-K12 acetylation (GO:0043983)4.30400877
18somite rostral/caudal axis specification (GO:0032525)4.17798023
19positive regulation of histone deacetylation (GO:0031065)4.05076246
20locomotory exploration behavior (GO:0035641)3.91572100
21negative regulation of epidermis development (GO:0045683)3.86495480
22response to dietary excess (GO:0002021)3.85561829
23regulation of mast cell degranulation (GO:0043304)3.83083429
24negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.80011931
25negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)3.79745736
26regulation of MHC class I biosynthetic process (GO:0045343)3.78564230
27muscle organ morphogenesis (GO:0048644)3.73268543
28pre-miRNA processing (GO:0031054)3.70008228
29regulation of telomere maintenance via telomerase (GO:0032210)3.64772311
30positive regulation by symbiont of host defense response (GO:0052509)3.64621240
31modulation by symbiont of host defense response (GO:0052031)3.64621240
32modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.64621240
33modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.64621240
34positive regulation by organism of defense response of other organism involved in symbiotic interact3.64621240
35modulation by symbiont of host immune response (GO:0052553)3.64621240
36positive regulation of protein deacetylation (GO:0090312)3.64027273
37histone H4-K16 acetylation (GO:0043984)3.63978272
38regulation of leukocyte degranulation (GO:0043300)3.60931737
39regulation of myeloid leukocyte mediated immunity (GO:0002886)3.57976403
40protein localization to kinetochore (GO:0034501)3.51391065
41negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)3.47173108
42heterochromatin organization (GO:0070828)3.45361966
43regulation of B cell receptor signaling pathway (GO:0050855)3.41875981
44hormone catabolic process (GO:0042447)3.41524048
45mitochondrion distribution (GO:0048311)3.37971526
46negative regulation of cell cycle G2/M phase transition (GO:1902750)3.37857449
47regulation of mast cell activation involved in immune response (GO:0033006)3.34825110
48regulation of T-helper 2 cell differentiation (GO:0045628)3.34740473
49regulation of ARF protein signal transduction (GO:0032012)3.33686346
50detection of temperature stimulus (GO:0016048)3.32577616
51positive regulation of gamma-delta T cell activation (GO:0046645)3.32424128
52positive regulation of macrophage cytokine production (GO:0060907)3.31193165
53antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.29029891
54regulation of short-term neuronal synaptic plasticity (GO:0048172)3.27248770
55response to peptidoglycan (GO:0032494)3.23973228
56regulation of regulated secretory pathway (GO:1903305)3.22212971
57regulation of nuclear cell cycle DNA replication (GO:0033262)3.21818955
58macrophage activation involved in immune response (GO:0002281)3.21426003
59retinoic acid receptor signaling pathway (GO:0048384)3.20639255
60tachykinin receptor signaling pathway (GO:0007217)3.18699732
61positive regulation of Rap GTPase activity (GO:0032854)3.18646563
62regulation of early endosome to late endosome transport (GO:2000641)3.18250566
63negative regulation of potassium ion transmembrane transport (GO:1901380)3.18114865
64negative regulation of cell size (GO:0045792)3.14951853
65interferon-gamma production (GO:0032609)3.12596580
66negative regulation of leukocyte mediated immunity (GO:0002704)3.12524162
67positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.11351105
68intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress (GO:0070059)3.08849727
69cytidine deamination (GO:0009972)3.07114499
70cytidine metabolic process (GO:0046087)3.07114499
71cytidine catabolic process (GO:0006216)3.07114499
72sodium ion export (GO:0071436)3.06555743
73rRNA transcription (GO:0009303)3.05608198
74glutamate secretion (GO:0014047)3.05450763
75primitive streak formation (GO:0090009)3.01355369
76maintenance of protein localization in organelle (GO:0072595)2.99859912
77antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.99645846
78negative regulation of peptidyl-serine phosphorylation (GO:0033137)2.99633333
79maternal placenta development (GO:0001893)2.98889353
80leukocyte aggregation (GO:0070486)2.98739463
81detection of other organism (GO:0098543)2.95958347
82regulation of activation of Janus kinase activity (GO:0010533)2.95314815
83branching involved in mammary gland duct morphogenesis (GO:0060444)2.95114471
84layer formation in cerebral cortex (GO:0021819)2.94872913
85adaptation of signaling pathway (GO:0023058)2.92445621
86positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.92117722
87calcium-mediated signaling using intracellular calcium source (GO:0035584)2.91445851
88mannose metabolic process (GO:0006013)2.91096236
89negative regulation of interleukin-12 production (GO:0032695)2.90635830
90regulation of Rap GTPase activity (GO:0032317)2.90006589
91response to muramyl dipeptide (GO:0032495)2.89630373
92detection of bacterium (GO:0016045)2.89355546
93hypotonic response (GO:0006971)2.89029617
94intracellular estrogen receptor signaling pathway (GO:0030520)2.88433169
95regulation of intracellular estrogen receptor signaling pathway (GO:0033146)2.84774385
96negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.82925693
97neutrophil activation involved in immune response (GO:0002283)2.81578117
98cell-cell junction maintenance (GO:0045217)2.80103858
99synaptic vesicle docking involved in exocytosis (GO:0016081)2.78856262
100negative regulation of cytokine production involved in immune response (GO:0002719)2.78569606
101mitotic sister chromatid segregation (GO:0000070)2.78424422
102cellular modified amino acid catabolic process (GO:0042219)2.78413281
103endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.76921492
104germinal center formation (GO:0002467)2.76247128
105signal complex assembly (GO:0007172)2.76195724
106positive regulation of synapse maturation (GO:0090129)2.75404982
107RNA stabilization (GO:0043489)2.74940933
108mRNA stabilization (GO:0048255)2.74940933
109antigen processing and presentation of endogenous antigen (GO:0019883)2.73333394
110positive regulation of muscle cell apoptotic process (GO:0010661)2.72937910
111phenol-containing compound catabolic process (GO:0019336)2.72731436
112modulation by symbiont of host cellular process (GO:0044068)2.70748763
113positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.69559265
114negative regulation of epidermal cell differentiation (GO:0045605)2.69180516
115regulation of synapse structural plasticity (GO:0051823)2.68856973
116NLS-bearing protein import into nucleus (GO:0006607)2.65846001
117regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.65539010
118leukocyte migration involved in inflammatory response (GO:0002523)2.65020316
119histone H4 deacetylation (GO:0070933)2.64799377
120vitamin A metabolic process (GO:0006776)2.64477957
121regulation of synaptic vesicle exocytosis (GO:2000300)2.64476513
122heparin metabolic process (GO:0030202)2.64073045
123heparin biosynthetic process (GO:0030210)2.64073045
124positive regulation of myotube differentiation (GO:0010831)2.63855797
125regulation of macrophage cytokine production (GO:0010935)2.62886290
126detection of external biotic stimulus (GO:0098581)2.62832941
127positive regulation of DNA-dependent DNA replication (GO:2000105)2.61924674
128vocalization behavior (GO:0071625)2.61098230
129regulation of cilium movement (GO:0003352)2.61053956
130coenzyme catabolic process (GO:0009109)2.60670880
131response to laminar fluid shear stress (GO:0034616)2.60014228
132establishment of endothelial barrier (GO:0061028)2.59936120
133regulation of ARF GTPase activity (GO:0032312)2.59776665
134pyrimidine ribonucleoside catabolic process (GO:0046133)2.59753088
135apoptotic DNA fragmentation (GO:0006309)2.59377457
136negative regulation of type 2 immune response (GO:0002829)2.57953300
137detection of molecule of bacterial origin (GO:0032490)2.57078937
138activation of MAPKKK activity (GO:0000185)2.56420784
139lipopolysaccharide-mediated signaling pathway (GO:0031663)2.56305314
140negative regulation of alpha-beta T cell activation (GO:0046636)2.56202286
141epithelial cell differentiation involved in prostate gland development (GO:0060742)2.56090755
142notochord development (GO:0030903)2.55664496
143positive regulation of protein dephosphorylation (GO:0035307)2.55629684
144intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator (GO:0042771)2.55112050
145positive regulation of axon extension (GO:0045773)2.54857295
146L-amino acid import (GO:0043092)2.54731969
147mitochondrion localization (GO:0051646)2.53679353
148synaptic vesicle exocytosis (GO:0016079)2.53459103
149antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.53423196
150regulation of glutamate receptor signaling pathway (GO:1900449)2.53403726
151chromatin assembly (GO:0031497)2.53111268
152neuromuscular process controlling balance (GO:0050885)2.52601022
153positive regulation of cellular amide metabolic process (GO:0034250)2.51689564
154neurotransmitter secretion (GO:0007269)2.51361036
155exploration behavior (GO:0035640)2.51020620
156cell migration involved in gastrulation (GO:0042074)2.50930618
157cell migration in hindbrain (GO:0021535)2.50401229
158protein localization to endosome (GO:0036010)2.50375662
159G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.44730363
160stress fiber assembly (GO:0043149)2.44240931
161detection of biotic stimulus (GO:0009595)2.41908028
162cellular response to epinephrine stimulus (GO:0071872)2.39454025
163granulocyte activation (GO:0036230)2.38833893
164regulation of gamma-delta T cell activation (GO:0046643)2.38074912
165regulation of mast cell activation (GO:0033003)2.37204748
166adenosine receptor signaling pathway (GO:0001973)2.35522083
167negative regulation of toll-like receptor signaling pathway (GO:0034122)2.35461262
168negative regulation of lymphocyte mediated immunity (GO:0002707)2.34238920
169negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.33995979
170negative regulation of granulocyte differentiation (GO:0030853)2.32130668
171cytoskeletal anchoring at plasma membrane (GO:0007016)2.30910716
172modulation by virus of host process (GO:0019054)2.30372924
173apoptotic process involved in morphogenesis (GO:0060561)2.29688280
174negative regulation of myotube differentiation (GO:0010832)2.29303233
175negative regulation of production of molecular mediator of immune response (GO:0002701)2.28846762
176regulation of type 2 immune response (GO:0002828)2.27745903
177positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.27259279
178creatine metabolic process (GO:0006600)2.25920657
179myeloid cell activation involved in immune response (GO:0002275)2.25887683
180positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.25799473
181response to host immune response (GO:0052572)2.25032567
182response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.25032567
183antigen processing and presentation via MHC class Ib (GO:0002475)2.24656542
184cellular response to monoamine stimulus (GO:0071868)2.23446950
185cellular response to catecholamine stimulus (GO:0071870)2.23446950
186peptidyl-tyrosine autophosphorylation (GO:0038083)2.22873792

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human5.71019015
2KLF5_18264089_ChIP-ChIP_MESCs_Mouse4.53517947
3KLF4_18264089_ChIP-ChIP_MESCs_Mouse4.53517947
4KLF2_18264089_ChIP-ChIP_MESCs_Mouse4.53517947
5SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.92032358
6* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.62762996
7* KDM2B_26808549_Chip-Seq_SUP-B15_Human2.51604069
8* ZFP281_18757296_ChIP-ChIP_E14_Mouse2.45505361
9NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.41142300
10IKZF1_21737484_ChIP-ChIP_HCT116_Human2.38356271
11* ZFP281_27345836_Chip-Seq_ESCs_Mouse2.21756917
12* ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.20642867
13MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.13027133
14THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.09092674
15LXR_22292898_ChIP-Seq_THP-1_Human2.07764220
16SOX2_18358816_ChIP-ChIP_MESCs_Mouse2.06607187
17* KDM2B_26808549_Chip-Seq_K562_Human2.05034707
18MYC_22102868_ChIP-Seq_BL_Human2.03030340
19RARG_19884340_ChIP-ChIP_MEFs_Mouse1.98944693
20* TCF7_22412390_ChIP-Seq_EML_Mouse1.98629676
21SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.98206526
22TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.98003777
23POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.90939092
24RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.87079907
25KDM2B_26808549_Chip-Seq_DND41_Human1.83080008
26VDR_24763502_ChIP-Seq_THP-1_Human1.77964015
27* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.76776732
28WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.72918290
29NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.69751020
30ELK3_25401928_ChIP-Seq_HUVEC_Human1.68324054
31* RARB_27405468_Chip-Seq_BRAIN_Mouse1.67660173
32SA1_27219007_Chip-Seq_ERYTHROID_Human1.67370920
33SCL_19346495_ChIP-Seq_HPC-7_Human1.65761839
34NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.64602270
35NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.63622291
36TCF3_18692474_ChIP-Seq_MESCs_Mouse1.61602409
37* MAF_26560356_Chip-Seq_TH1_Human1.58473932
38* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.56597200
39SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.54607773
40MAF_26560356_Chip-Seq_TH2_Human1.53574161
41* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.51649196
42TET1_21451524_ChIP-Seq_MESCs_Mouse1.50751171
43TCF3_18692474_ChIP-Seq_MEFs_Mouse1.49492500
44RUNX1_22412390_ChIP-Seq_EML_Mouse1.47640925
45SMC4_20622854_ChIP-Seq_HELA_Human1.46960387
46UTX_26944678_Chip-Seq_JUKART_Human1.46911049
47* ERG_21242973_ChIP-ChIP_JURKAT_Human1.46207036
48ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.45701914
49* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.43668127
50TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.41965307
51UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.41582739
52POU5F1_16518401_ChIP-PET_MESCs_Mouse1.41165781
53NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.41079225
54MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.39662850
55SPI1_23127762_ChIP-Seq_K562_Human1.39619603
56TP63_19390658_ChIP-ChIP_HaCaT_Human1.39354071
57* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.38857326
58NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.38676233
59VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.37953561
60TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.33766445
61CDX2_20551321_ChIP-Seq_CACO-2_Human1.33530430
62* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.33009474
63RACK7_27058665_Chip-Seq_MCF-7_Human1.31785682
64SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.31695341
65GATA1_19941827_ChIP-Seq_MEL_Mouse1.31220331
66* CTCF_27219007_Chip-Seq_Bcells_Human1.31157567
67TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.30923802
68STAT6_21828071_ChIP-Seq_BEAS2B_Human1.30108931
69* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.29715971
70* KDM2B_26808549_Chip-Seq_JURKAT_Human1.28695444
71* DNAJC2_21179169_ChIP-ChIP_NT2_Human1.28186044
72PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.27802680
73PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.26979636
74KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.26289291
75GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.25807434
76* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.25020785
77E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.24836719
78BCL6_27268052_Chip-Seq_Bcells_Human1.24268593
79VDR_21846776_ChIP-Seq_THP-1_Human1.23918926
80TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.20839024
81TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.20180092
82MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.20150211
83ESR2_21235772_ChIP-Seq_MCF-7_Human1.19901815
84HIF1A_21447827_ChIP-Seq_MCF-7_Human1.19269157
85NCOR1_26117541_ChIP-Seq_K562_Human1.17952030
86TP53_22127205_ChIP-Seq_IMR90_Human1.17779216
87SUZ12_27294783_Chip-Seq_ESCs_Mouse1.17461309
88* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.15948403
89RNF2_18974828_ChIP-Seq_MESCs_Mouse1.15619106
90EZH2_18974828_ChIP-Seq_MESCs_Mouse1.15619106
91MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.15562203
92DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.12985490
93* P68_20966046_ChIP-Seq_HELA_Human1.11678650
94CTCF_27219007_Chip-Seq_ERYTHROID_Human1.11626410
95PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.11586706
96JARID2_20075857_ChIP-Seq_MESCs_Mouse1.10872809
97E2F1_17053090_ChIP-ChIP_MCF-7_Human1.10827037
98RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.10659280
99* TET1_21490601_ChIP-Seq_MESCs_Mouse1.08509538
100TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.08351638
101* REST_18959480_ChIP-ChIP_MESCs_Mouse1.08186081
102ELF1_20517297_ChIP-Seq_JURKAT_Human1.07998134
103EGR1_19374776_ChIP-ChIP_THP-1_Human1.07892739
104* RING1B_27294783_Chip-Seq_NPCs_Mouse1.07702787
105SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.07387423
106P300_27058665_Chip-Seq_ZR-75-30cells_Human1.03906935
107PU.1_20513432_ChIP-Seq_Bcells_Mouse1.03899135
108SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.03199616
109EZH2_22144423_ChIP-Seq_EOC_Human1.03189988
110GATA1_22383799_ChIP-Seq_G1ME_Mouse1.02926802
111ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.02901462
112STAT3_1855785_ChIP-Seq_MESCs_Mouse1.02771980
113* EZH2_27294783_Chip-Seq_ESCs_Mouse1.01708726
114CREB1_26743006_Chip-Seq_LNCaP_Human1.01500108
115* REST_21632747_ChIP-Seq_MESCs_Mouse1.01485101
116CTCF_21964334_ChIP-Seq_BJAB-B_Human1.00968889
117* SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.99888174
118PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.99215996
119NANOG_18692474_ChIP-Seq_MESCs_Mouse0.98701675
120* SRY_22984422_ChIP-ChIP_TESTIS_Rat0.98658306
121* CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.98140796
122NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.98120900
123TP53_20018659_ChIP-ChIP_R1E_Mouse0.97640564
124TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.97412915
125BCOR_27268052_Chip-Seq_Bcells_Human0.96968749
126NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.96837128
127NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.96795246
128* CTCF_26484167_Chip-Seq_Bcells_Mouse0.95946623
129EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.95067972
130MYB_21317192_ChIP-Seq_ERMYB_Mouse0.94411903
131PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.94297673
132* IRF8_27001747_Chip-Seq_BMDM_Mouse0.94192333
133CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.93002395
134DROSHA_22980978_ChIP-Seq_HELA_Human0.92701042
135POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.92483417
136RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.91743831
137* SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.91446486
138TP63_22573176_ChIP-Seq_HFKS_Human0.90675205
139OCT4_19829295_ChIP-Seq_ESCs_Human0.89464090
140CTCF_21964334_Chip-Seq_Bcells_Human0.88990066
141NANOG_16518401_ChIP-PET_MESCs_Mouse0.88843778
142SA1_27219007_Chip-Seq_Bcells_Human0.85759846
143WT1_25993318_ChIP-Seq_PODOCYTE_Human0.85705786

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004858_abnormal_nervous_system4.68935477
2MP0004859_abnormal_synaptic_plasticity4.19379960
3MP0002254_reproductive_system_inflammat3.58583430
4MP0003436_decreased_susceptibility_to3.32334795
5MP0003705_abnormal_hypodermis_morpholog3.27031895
6MP0003122_maternal_imprinting3.11975016
7MP0004264_abnormal_extraembryonic_tissu3.09920254
8MP0008961_abnormal_basal_metabolism3.02244204
9MP0003011_delayed_dark_adaptation2.90630246
10MP0005058_abnormal_lysosome_morphology2.75825700
11MP0002332_abnormal_exercise_endurance2.56897392
12MP0006292_abnormal_olfactory_placode2.56686879
13MP0005499_abnormal_olfactory_system2.47831892
14MP0005394_taste/olfaction_phenotype2.47831892
15MP0003724_increased_susceptibility_to2.38681129
16MP0005451_abnormal_body_composition2.35927255
17MP0003172_abnormal_lysosome_physiology2.23285841
18MP0005075_abnormal_melanosome_morpholog2.21186108
19MP0003890_abnormal_embryonic-extraembry2.14987379
20MP0003329_amyloid_beta_deposits2.13094500
21MP0005167_abnormal_blood-brain_barrier2.06249784
22MP0003635_abnormal_synaptic_transmissio2.01512269
23MP0003300_gastrointestinal_ulcer2.00305558
24MP0002419_abnormal_innate_immunity1.95521134
25MP0002653_abnormal_ependyma_morphology1.91629803
26MP0000604_amyloidosis1.89139058
27MP0003183_abnormal_peptide_metabolism1.88918365
28MP0008260_abnormal_autophagy1.86263638
29MP0006082_CNS_inflammation1.84851274
30MP0009046_muscle_twitch1.76970223
31MP0002909_abnormal_adrenal_gland1.75342716
32MP0003121_genomic_imprinting1.75141039
33MP0005025_abnormal_response_to1.71640117
34MP0002249_abnormal_larynx_morphology1.71402203
35MP0001849_ear_inflammation1.64944621
36MP0001533_abnormal_skeleton_physiology1.63744776
37MP0004130_abnormal_muscle_cell1.61887105
38MP0002063_abnormal_learning/memory/cond1.57997608
39MP0002064_seizures1.55985714
40MP0003075_altered_response_to1.54159215
41MP0000751_myopathy1.52604437
42MP0005000_abnormal_immune_tolerance1.51967792
43MP0003283_abnormal_digestive_organ1.51901539
44MP0010352_gastrointestinal_tract_polyps1.50658438
45MP0003279_aneurysm1.49062759
46MP0010368_abnormal_lymphatic_system1.48907273
47MP0003787_abnormal_imprinting1.46464545
48MP0003303_peritoneal_inflammation1.44370771
49MP0003879_abnormal_hair_cell1.41433032
50MP0002572_abnormal_emotion/affect_behav1.39155273
51MP0004270_analgesia1.39047172
52MP0005409_darkened_coat_color1.38843850
53MP0000747_muscle_weakness1.36720199
54MP0001835_abnormal_antigen_presentation1.35968067
55MP0005666_abnormal_adipose_tissue1.34436941
56MP0005257_abnormal_intraocular_pressure1.33227166
57MP0009840_abnormal_foam_cell1.32998548
58MP0003123_paternal_imprinting1.29518494
59MP0006035_abnormal_mitochondrial_morpho1.29254804
60MP0002998_abnormal_bone_remodeling1.29098852
61MP0001545_abnormal_hematopoietic_system1.26692056
62MP0005397_hematopoietic_system_phenotyp1.26692056
63MP0000920_abnormal_myelination1.26083728
64MP0001790_abnormal_immune_system1.25831909
65MP0005387_immune_system_phenotype1.25831909
66MP0003646_muscle_fatigue1.25828962
67MP0001486_abnormal_startle_reflex1.24949333
68MP0000678_abnormal_parathyroid_gland1.24409309
69MP0001958_emphysema1.23780883
70MP0003137_abnormal_impulse_conducting1.22971270
71MP0004185_abnormal_adipocyte_glucose1.21318369
72MP0002723_abnormal_immune_serum1.20586404
73MP0008770_decreased_survivor_rate1.19847673
74MP0002420_abnormal_adaptive_immunity1.19390566
75MP0003938_abnormal_ear_development1.18609186
76MP0001501_abnormal_sleep_pattern1.18330876
77MP0001819_abnormal_immune_cell1.17898460
78MP0005623_abnormal_meninges_morphology1.17627612
79MP0009745_abnormal_behavioral_response1.15837713
80MP0001348_abnormal_lacrimal_gland1.14527196
81MP0002127_abnormal_cardiovascular_syste1.13800347
82MP0000750_abnormal_muscle_regeneration1.12524859
83MP0000955_abnormal_spinal_cord1.12053307
84MP0002088_abnormal_embryonic_growth/wei1.10856817
85MP0000685_abnormal_immune_system1.10843661
86MP0004947_skin_inflammation1.10404170
87MP0001672_abnormal_embryogenesis/_devel1.10186668
88MP0005380_embryogenesis_phenotype1.10186668
89MP0003984_embryonic_growth_retardation1.08450320
90MP0009278_abnormal_bone_marrow1.07588027
91MP0002733_abnormal_thermal_nociception1.07082802
92MP0005464_abnormal_platelet_physiology1.06373926
93MP0004510_myositis1.04745013
94MP0002452_abnormal_antigen_presenting1.04645194
95MP0005375_adipose_tissue_phenotype1.04576908
96MP0002396_abnormal_hematopoietic_system1.03456894
97MP0001800_abnormal_humoral_immune1.03346679
98MP0002148_abnormal_hypersensitivity_rea1.03270257
99MP0005166_decreased_susceptibility_to1.02069676
100MP0009785_altered_susceptibility_to1.01816242
101MP0004811_abnormal_neuron_physiology1.01011348
102MP0000858_altered_metastatic_potential1.00584486
103MP0004087_abnormal_muscle_fiber1.00090818
104MP0002925_abnormal_cardiovascular_devel0.99944019
105MP0002970_abnormal_white_adipose0.99654749
106MP0000343_altered_response_to0.99316843
107MP0003045_fibrosis0.98401805
108MP0003828_pulmonary_edema0.98003417
109MP0005390_skeleton_phenotype0.95553354
110MP0004036_abnormal_muscle_relaxation0.95532983
111MP0002086_abnormal_extraembryonic_tissu0.95443982
112MP0005423_abnormal_somatic_nervous0.94279172
113MP0000733_abnormal_muscle_development0.92327548
114MP0008874_decreased_physiological_sensi0.91642875
115MP0000767_abnormal_smooth_muscle0.91179690
116MP0002405_respiratory_system_inflammati0.90756969
117MP0005671_abnormal_response_to0.89101215
118MP0003091_abnormal_cell_migration0.88427174
119MP0008438_abnormal_cutaneous_collagen0.86904169
120MP0004381_abnormal_hair_follicle0.86700479
121MP0008569_lethality_at_weaning0.85608801
122MP0000716_abnormal_immune_system0.85204775
123MP0001970_abnormal_pain_threshold0.84477717
124MP0002398_abnormal_bone_marrow0.83645642
125MP0004085_abnormal_heartbeat0.83223848
126MP0002932_abnormal_joint_morphology0.83205683
127MP0004883_abnormal_blood_vessel0.82360615
128MP0003119_abnormal_digestive_system0.81679259
129MP0003763_abnormal_thymus_physiology0.81448613
130MP0003633_abnormal_nervous_system0.81396371
131MP0002269_muscular_atrophy0.81124947
132MP0003453_abnormal_keratinocyte_physiol0.80675036
133MP0004808_abnormal_hematopoietic_stem0.80571609
134MP0002184_abnormal_innervation0.80079224
135MP0000703_abnormal_thymus_morphology0.75054622
136MP0002106_abnormal_muscle_physiology0.73459969
137MP0002933_joint_inflammation0.73338528
138MP0004233_abnormal_muscle_weight0.73329264
139MP0004885_abnormal_endolymph0.72338458
140MP0002272_abnormal_nervous_system0.72169594
141MP0003448_altered_tumor_morphology0.72024848
142MP0005248_abnormal_Harderian_gland0.71664204
143MP0002092_abnormal_eye_morphology0.71235441
144MP0000428_abnormal_craniofacial_morphol0.70721114
145MP0003690_abnormal_glial_cell0.70356543
146MP0010630_abnormal_cardiac_muscle0.69808562
147MP0003935_abnormal_craniofacial_develop0.69547751
148MP0008872_abnormal_physiological_respon0.68383648
149MP0005266_abnormal_metabolism0.68081682
150MP0002734_abnormal_mechanical_nocicepti0.67981756
151MP0001293_anophthalmia0.66613122
152MP0002114_abnormal_axial_skeleton0.66141640
153MP0005076_abnormal_cell_differentiation0.65039763
154MP0002084_abnormal_developmental_patter0.62862738
155MP0003566_abnormal_cell_adhesion0.62817597
156MP0002277_abnormal_respiratory_mucosa0.62430312
157MP0002085_abnormal_embryonic_tissue0.61215873
158MP0004142_abnormal_muscle_tone0.60864863
159MP0003634_abnormal_glial_cell0.59751590
160MP0008057_abnormal_DNA_replication0.58882267
161MP0009115_abnormal_fat_cell0.58398229
162MP0000759_abnormal_skeletal_muscle0.58012780
163MP0003191_abnormal_cellular_cholesterol0.57752433
164MP0002882_abnormal_neuron_morphology0.57584382
165MP0005023_abnormal_wound_healing0.57536357

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the lower motor neuron (HP:0002366)6.22375163
2Bilateral microphthalmos (HP:0007633)5.74302901
3Hepatoblastoma (HP:0002884)4.77772801
4Hypochromic microcytic anemia (HP:0004840)4.59330412
5Ependymoma (HP:0002888)3.60928514
6Obstructive sleep apnea (HP:0002870)3.60038128
7Multiple enchondromatosis (HP:0005701)3.49504367
8Amyotrophic lateral sclerosis (HP:0007354)3.44428091
9Rib fusion (HP:0000902)3.38288076
10Eczematoid dermatitis (HP:0000976)3.36543014
11Astrocytoma (HP:0009592)3.10052498
12Abnormality of the astrocytes (HP:0100707)3.10052498
13Increased variability in muscle fiber diameter (HP:0003557)3.09468681
14Neoplasm of the heart (HP:0100544)3.02582049
15Cerebral inclusion bodies (HP:0100314)2.96201327
16Horizontal nystagmus (HP:0000666)2.94586564
17Neoplasm of striated muscle (HP:0009728)2.89878584
18Hand muscle atrophy (HP:0009130)2.89673766
19Generalized hypotonia (HP:0001290)2.83590528
20Renal duplication (HP:0000075)2.82605683
21Annular pancreas (HP:0001734)2.82588754
22Abnormality of skeletal muscle fiber size (HP:0012084)2.80210207
23Abnormality of macrophages (HP:0004311)2.73217298
24Tetraplegia (HP:0002445)2.72337520
25Neurofibrillary tangles (HP:0002185)2.71085641
26Testicular atrophy (HP:0000029)2.70932118
27Difficulty running (HP:0009046)2.69119557
28Myositis (HP:0100614)2.69084296
29Distal upper limb amyotrophy (HP:0007149)2.64371698
30Upper limb amyotrophy (HP:0009129)2.64371698
31Achilles tendon contracture (HP:0001771)2.64096419
32Recurrent abscess formation (HP:0002722)2.61673275
33Abnormality of glycolipid metabolism (HP:0010969)2.58038082
34Abnormality of liposaccharide metabolism (HP:0010968)2.58038082
35Abnormality of glycosphingolipid metabolism (HP:0004343)2.58038082
36Centrally nucleated skeletal muscle fibers (HP:0003687)2.55014582
37Recurrent bacterial skin infections (HP:0005406)2.53468903
38Orchitis (HP:0100796)2.51514830
39Chronic obstructive pulmonary disease (HP:0006510)2.51238958
40Obstructive lung disease (HP:0006536)2.51238958
41Amblyopia (HP:0000646)2.47574446
42Hemiparesis (HP:0001269)2.46719711
43Febrile seizures (HP:0002373)2.44397854
44Upper motor neuron abnormality (HP:0002127)2.43648674
45Ankle clonus (HP:0011448)2.40466830
46Intestinal fistula (HP:0100819)2.38597632
47Ragged-red muscle fibers (HP:0003200)2.38218965
48Abnormality of the Achilles tendon (HP:0005109)2.37154893
49Focal seizures (HP:0007359)2.36056841
50Gingivitis (HP:0000230)2.35889100
51Insomnia (HP:0100785)2.35588595
52Rectovaginal fistula (HP:0000143)2.35150285
53Rectal fistula (HP:0100590)2.35150285
54Abnormality of the nasal mucosa (HP:0000433)2.33624823
55Apathy (HP:0000741)2.31913735
56Muscle fiber splitting (HP:0003555)2.31291054
57Visual hallucinations (HP:0002367)2.30579044
58Myokymia (HP:0002411)2.29072587
59Dysostosis multiplex (HP:0000943)2.26169064
60Cellulitis (HP:0100658)2.23375518
61Asymmetric septal hypertrophy (HP:0001670)2.21574963
62Metaphyseal cupping (HP:0003021)2.20795748
63Spontaneous hematomas (HP:0007420)2.20291298
64Nephroblastoma (Wilms tumor) (HP:0002667)2.19560980
65Rhabdomyosarcoma (HP:0002859)2.19092702
66Axonal loss (HP:0003447)2.17869239
67Nasal polyposis (HP:0100582)2.17860144
68Resting tremor (HP:0002322)2.17337822
69Fused cervical vertebrae (HP:0002949)2.17293682
70Retrobulbar optic neuritis (HP:0100654)2.16226151
71Optic neuritis (HP:0100653)2.16226151
72Recurrent gram-negative bacterial infections (HP:0005420)2.16013274
73Macroorchidism (HP:0000053)2.15959920
74Renovascular hypertension (HP:0100817)2.15660625
75Large earlobe (HP:0009748)2.15638253
76Abnormality of the salivary glands (HP:0010286)2.14319901
77Status epilepticus (HP:0002133)2.14309319
78Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.14225596
79Partial duplication of thumb phalanx (HP:0009944)2.14108731
80Abnormality of the musculature of the hand (HP:0001421)2.13644891
81Vaginal fistula (HP:0004320)2.13239870
82Increased IgE level (HP:0003212)2.12653852
83Diminished motivation (HP:0000745)2.11689431
84Exercise-induced myalgia (HP:0003738)2.10645929
85Pseudobulbar signs (HP:0002200)2.09465772
86Mediastinal lymphadenopathy (HP:0100721)2.09453486
87Glioma (HP:0009733)2.08937018
88Mitral regurgitation (HP:0001653)2.08617766
89Preauricular skin tag (HP:0000384)2.08259767
90Gastrointestinal infarctions (HP:0005244)2.07996402
91Cerebral aneurysm (HP:0004944)2.07256937
92Myopathic facies (HP:0002058)2.05728075
93Malignant neoplasm of the central nervous system (HP:0100836)2.05436572
94Lymphangioma (HP:0100764)2.05402615
95Diplopia (HP:0000651)2.04226308
96Abnormality of binocular vision (HP:0011514)2.04226308
97Spastic tetraparesis (HP:0001285)2.03239389
98Hyperventilation (HP:0002883)2.03084053
99Type 1 muscle fiber predominance (HP:0003803)2.02241699
100Epileptic encephalopathy (HP:0200134)2.01392039
101Skin tags (HP:0010609)2.01178216
102Abnormality of the motor neurons (HP:0002450)2.00097081
103Abnormal neuron morphology (HP:0012757)2.00097081
104Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.99956737
105Embryonal renal neoplasm (HP:0011794)1.99733075
106EMG: neuropathic changes (HP:0003445)1.99358474
107Supernumerary nipples (HP:0002558)1.97682286
108Peripheral hypomyelination (HP:0007182)1.97185330
109Neuronal loss in central nervous system (HP:0002529)1.96721536
110Thin bony cortex (HP:0002753)1.96097991
111Supranuclear gaze palsy (HP:0000605)1.96037711
112Abnormality of chromosome segregation (HP:0002916)1.95723588
113Hypochromic anemia (HP:0001931)1.95153588
114Hypopigmentation of the fundus (HP:0007894)1.94992565
115Disproportionate tall stature (HP:0001519)1.94903140
116Absent frontal sinuses (HP:0002688)1.94685773
117Pointed chin (HP:0000307)1.94396158
118Hyperacusis (HP:0010780)1.94363492
119Bowel incontinence (HP:0002607)1.93356450
120Partial duplication of the phalanx of hand (HP:0009999)1.92039525
121Hemiplegia (HP:0002301)1.90722723
122Polygenic inheritance (HP:0010982)1.90634209
123Protrusio acetabuli (HP:0003179)1.90325766
124Short humerus (HP:0005792)1.89822037
125Shawl scrotum (HP:0000049)1.89412814
126Increased cerebral lipofuscin (HP:0011813)1.88544111
127Broad face (HP:0000283)1.87630366
128Abnormality of the pubic bones (HP:0003172)1.87052237
129Rapidly progressive (HP:0003678)1.86332454
130Elfin facies (HP:0004428)1.86252190
131Multifactorial inheritance (HP:0001426)1.86198227
132Loss of speech (HP:0002371)1.86030945
133Turricephaly (HP:0000262)1.85703044
134Abnormal large intestine physiology (HP:0012700)1.82980577
135Nuclear cataract (HP:0100018)1.82874835
136Bulbar palsy (HP:0001283)1.82621642
137Dialeptic seizures (HP:0011146)1.81952994
138Segmental peripheral demyelination/remyelination (HP:0003481)1.81884597
139Shallow orbits (HP:0000586)1.81771698
140Difficulty climbing stairs (HP:0003551)1.81629434
141Open mouth (HP:0000194)1.81103699
142Increased connective tissue (HP:0009025)1.80199155
143Overriding aorta (HP:0002623)1.79682168
144Lymphedema (HP:0001004)1.79515731
145Distal lower limb amyotrophy (HP:0008944)1.79418843
146Neuroectodermal neoplasm (HP:0030061)1.78544190
147Neuroepithelial neoplasm (HP:0030063)1.78544190
148Nervous tissue neoplasm (HP:0030060)1.78544190
149Round ear (HP:0100830)1.78228136
150Periauricular skin pits (HP:0100277)1.76570276
151Preauricular pit (HP:0004467)1.76570276
152Bifid tongue (HP:0010297)1.76530322
153Action tremor (HP:0002345)1.76502828
154Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.76221104
155Spinal muscular atrophy (HP:0007269)1.76067319
156Atrophy/Degeneration involving motor neurons (HP:0007373)1.73908343
157Hyperinsulinemic hypoglycemia (HP:0000825)1.73660062
158Chest pain (HP:0100749)1.73464980
159Aplasia/hypoplasia of the humerus (HP:0006507)1.73232643
160Truncus arteriosus (HP:0001660)1.72340943
161Slow saccadic eye movements (HP:0000514)1.72050512
162Abnormality of the endocardium (HP:0004306)1.70020748
163Flat cornea (HP:0007720)1.68180140
164Mutism (HP:0002300)1.67568791
165Stridor (HP:0010307)1.67364937
166Hypercortisolism (HP:0001578)1.66705586
167Peritonitis (HP:0002586)1.66628668
168Lower limb amyotrophy (HP:0007210)1.66257252
169Amyloidosis (HP:0011034)1.63988208
170Gastrointestinal dysmotility (HP:0002579)1.63809709
171Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.63790667
172Bladder diverticulum (HP:0000015)1.63115954
173Hyporeflexia of lower limbs (HP:0002600)1.61916598
174Ulnar deviation of the wrist (HP:0003049)1.61528636
175Spinal canal stenosis (HP:0003416)1.61230015
176Meningitis (HP:0001287)1.60392755
177Hypercalcemia (HP:0003072)1.60289162
178Genu recurvatum (HP:0002816)1.59781498
179Gastrointestinal inflammation (HP:0004386)1.59041430
180Hypertriglyceridemia (HP:0002155)1.58882417

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK125.74017263
2GRK54.19135863
3ERN14.05002887
4GRK63.04906796
5TYRO32.92211832
6MAP3K92.89053160
7TGFBR22.63715482
8MAP2K32.44919894
9CSF1R2.23733959
10MATK2.09901821
11TRIB32.00898756
12RIPK11.98766009
13CDC42BPA1.96032412
14ADRBK21.92505154
15NTRK11.90067883
16GRK11.86523844
17SIK21.66052747
18GRK71.63800961
19MAPK71.63572809
20WNK11.61185423
21MOS1.60216588
22ALK1.57242594
23MAP2K41.57166502
24NTRK31.55440568
25SMG11.55013041
26IRAK41.54040965
27CAMK41.51817454
28MARK21.40974333
29TAOK21.36965776
30ZAP701.31876073
31PAK61.31652407
32PRKG21.30267790
33TTN1.29115823
34EPHB11.28050334
35ICK1.26452299
36PRKD31.24586846
37STK101.22045548
38LIMK11.21263303
39IRAK31.20541253
40MAP3K11.17684477
41STK381.14875134
42PAK41.14775036
43CAMKK11.14684051
44PKN21.13831037
45NTRK21.13280106
46FGFR41.12315797
47KSR21.10611643
48PDPK11.08164260
49TYK21.07036337
50TAOK11.05964632
51HIPK21.04981637
52EPHA41.03279518
53DAPK20.99751788
54MAP3K100.98322858
55MAP3K70.98321501
56BMX0.90894211
57PDGFRA0.90119571
58MAP3K30.89297381
59FGFR30.89217246
60DYRK1B0.88325790
61LATS20.87388145
62CSK0.86565483
63FES0.86214652
64PRKCH0.86045832
65TTK0.84821060
66ARAF0.84105939
67MINK10.79369631
68TBK10.78355726
69TIE10.77591810
70MAPK120.77498405
71RPS6KA20.76758060
72JAK30.75155750
73RPS6KC10.72969569
74RPS6KL10.72969569
75CAMK1D0.70333361
76CAMK1G0.69302006
77MAP3K60.68717390
78MAP2K60.68434136
79PTK20.66529476
80STK160.65827429
81TESK10.64187898
82MARK10.64160545
83BTK0.62764776
84CAMK10.60860573
85PDK10.58741006
86ADRBK10.56671861
87NME20.56641741
88DDR20.56149902
89PRKD20.55200849
90DAPK10.54701751
91CDK190.54213855
92RPS6KA60.53722433
93HCK0.53453681
94MTOR0.52611162
95SGK30.52423839
96CDK50.52409480
97IRAK20.51632914
98CLK10.51224780
99CDK70.51203825
100TNK20.50120031
101MAP3K40.48612633
102AKT20.47929335
103RIPK40.47783283
104EEF2K0.47429798
105PRPF4B0.47226299
106SYK0.46610863
107CAMKK20.46267967
108SIK30.45603385
109MAPK40.44068424
110STK110.43687690
111MAPK100.43326626
112DMPK0.42925433
113UHMK10.42859818
114CDK150.41815742
115MAP3K130.39971206
116SIK10.38705309
117CDK11A0.38093383
118MAP4K10.36372332
119PRKCG0.36129396
120PHKG20.35978914
121PHKG10.35978914
122CDK180.35803367
123RPS6KA30.32948006
124ERBB20.32860149
125RET0.32088093
126IGF1R0.30560131
127LMTK20.30483112
128PTK60.29383564
129JAK20.29154724
130FGR0.27894833
131MAP3K110.27778155
132SRC0.27601849
133CDK140.27476766
134NEK10.27428206
135CHEK20.27341448
136ITK0.26997407
137BLK0.26489622

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006033.51364611
2Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.27072157
3Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.21004459
4Vitamin B6 metabolism_Homo sapiens_hsa007502.16691604
5Osteoclast differentiation_Homo sapiens_hsa043802.05484923
6Fructose and mannose metabolism_Homo sapiens_hsa000511.91517475
7mTOR signaling pathway_Homo sapiens_hsa041501.80575232
8Glutamatergic synapse_Homo sapiens_hsa047241.70657789
9Long-term potentiation_Homo sapiens_hsa047201.66754888
10Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.61761614
11GABAergic synapse_Homo sapiens_hsa047271.58326995
12Toll-like receptor signaling pathway_Homo sapiens_hsa046201.53335200
13Phospholipase D signaling pathway_Homo sapiens_hsa040721.52665025
14Synaptic vesicle cycle_Homo sapiens_hsa047211.50930616
15Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.45239571
16Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.42338877
17Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.42231896
18Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.38399618
19Galactose metabolism_Homo sapiens_hsa000521.37097474
20Nitrogen metabolism_Homo sapiens_hsa009101.35853702
21Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.35627273
22Glycosaminoglycan degradation_Homo sapiens_hsa005311.35259421
23VEGF signaling pathway_Homo sapiens_hsa043701.34402823
24Nicotine addiction_Homo sapiens_hsa050331.32774817
25Tuberculosis_Homo sapiens_hsa051521.32281229
26Olfactory transduction_Homo sapiens_hsa047401.31975068
27Salivary secretion_Homo sapiens_hsa049701.31725541
28Circadian entrainment_Homo sapiens_hsa047131.30985011
29GnRH signaling pathway_Homo sapiens_hsa049121.30870476
30Malaria_Homo sapiens_hsa051441.26183200
31Prion diseases_Homo sapiens_hsa050201.22540383
32AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.21765243
33Phosphatidylinositol signaling system_Homo sapiens_hsa040701.20992104
34Neurotrophin signaling pathway_Homo sapiens_hsa047221.16843871
35Oxytocin signaling pathway_Homo sapiens_hsa049211.16741814
36Long-term depression_Homo sapiens_hsa047301.15090637
37Thyroid hormone signaling pathway_Homo sapiens_hsa049191.12736314
38Non-small cell lung cancer_Homo sapiens_hsa052231.11954110
39Rap1 signaling pathway_Homo sapiens_hsa040151.11843577
40Dorso-ventral axis formation_Homo sapiens_hsa043201.11522007
41Morphine addiction_Homo sapiens_hsa050321.06398768
42cAMP signaling pathway_Homo sapiens_hsa040241.06011958
43Central carbon metabolism in cancer_Homo sapiens_hsa052301.05957489
44Choline metabolism in cancer_Homo sapiens_hsa052311.05114861
45Insulin signaling pathway_Homo sapiens_hsa049101.04939166
46Aldosterone synthesis and secretion_Homo sapiens_hsa049251.03797076
47Glioma_Homo sapiens_hsa052141.03545732
48Prolactin signaling pathway_Homo sapiens_hsa049171.02380751
49Calcium signaling pathway_Homo sapiens_hsa040201.01511705
50Toxoplasmosis_Homo sapiens_hsa051451.01253730
51T cell receptor signaling pathway_Homo sapiens_hsa046601.01242693
52Staphylococcus aureus infection_Homo sapiens_hsa051501.00900975
53Inositol phosphate metabolism_Homo sapiens_hsa005621.00599271
54Bladder cancer_Homo sapiens_hsa052190.99275509
55Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.98436224
56Regulation of actin cytoskeleton_Homo sapiens_hsa048100.98309996
57TNF signaling pathway_Homo sapiens_hsa046680.97652621
58Amoebiasis_Homo sapiens_hsa051460.97181555
59Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.96558380
60Acute myeloid leukemia_Homo sapiens_hsa052210.96522499
61Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.96454789
62Gastric acid secretion_Homo sapiens_hsa049710.96001402
63Salmonella infection_Homo sapiens_hsa051320.95259747
64Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.94302135
65Dopaminergic synapse_Homo sapiens_hsa047280.92609441
66Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.90886377
67Renin secretion_Homo sapiens_hsa049240.90671737
68Lysosome_Homo sapiens_hsa041420.90101226
69Taste transduction_Homo sapiens_hsa047420.89477816
70Gap junction_Homo sapiens_hsa045400.87851046
71Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.86957924
72B cell receptor signaling pathway_Homo sapiens_hsa046620.86774299
73Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.86387740
74Estrogen signaling pathway_Homo sapiens_hsa049150.86342966
75NOD-like receptor signaling pathway_Homo sapiens_hsa046210.85195281
76Cholinergic synapse_Homo sapiens_hsa047250.85078261
77Notch signaling pathway_Homo sapiens_hsa043300.84208742
78Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.83640066
79Influenza A_Homo sapiens_hsa051640.83494650
80Dilated cardiomyopathy_Homo sapiens_hsa054140.81248122
81Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.80378733
82Longevity regulating pathway - mammal_Homo sapiens_hsa042110.80157345
83NF-kappa B signaling pathway_Homo sapiens_hsa040640.78469397
84Proteoglycans in cancer_Homo sapiens_hsa052050.78081358
85Hepatitis C_Homo sapiens_hsa051600.77961916
86ErbB signaling pathway_Homo sapiens_hsa040120.76434128
87MAPK signaling pathway_Homo sapiens_hsa040100.76429130
88Thyroid cancer_Homo sapiens_hsa052160.76371699
89Hepatitis B_Homo sapiens_hsa051610.76076739
90Pertussis_Homo sapiens_hsa051330.75598068
91Amphetamine addiction_Homo sapiens_hsa050310.75314023
92Type II diabetes mellitus_Homo sapiens_hsa049300.75045966
93Legionellosis_Homo sapiens_hsa051340.75003094
94Endocytosis_Homo sapiens_hsa041440.74857734
95Sphingolipid signaling pathway_Homo sapiens_hsa040710.74090471
96Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.73475636
97Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.71845676
98Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.71769650
99Serotonergic synapse_Homo sapiens_hsa047260.70865059
100Platelet activation_Homo sapiens_hsa046110.70275773
101Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.69773164
102Other glycan degradation_Homo sapiens_hsa005110.69546307
103Measles_Homo sapiens_hsa051620.69293489
104Pancreatic cancer_Homo sapiens_hsa052120.68319997
105Vascular smooth muscle contraction_Homo sapiens_hsa042700.67947477
106Leukocyte transendothelial migration_Homo sapiens_hsa046700.67531972
107Carbohydrate digestion and absorption_Homo sapiens_hsa049730.66177606
108cGMP-PKG signaling pathway_Homo sapiens_hsa040220.66026316
109Colorectal cancer_Homo sapiens_hsa052100.65778707
110Ovarian steroidogenesis_Homo sapiens_hsa049130.65010791
111Focal adhesion_Homo sapiens_hsa045100.64432430
112* RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.63808472
113Insulin secretion_Homo sapiens_hsa049110.63382525
114Bile secretion_Homo sapiens_hsa049760.62969999
115Viral myocarditis_Homo sapiens_hsa054160.62895902
116FoxO signaling pathway_Homo sapiens_hsa040680.62371894
117Chemokine signaling pathway_Homo sapiens_hsa040620.62261757
118Jak-STAT signaling pathway_Homo sapiens_hsa046300.61787982
119Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.61648292
120Endometrial cancer_Homo sapiens_hsa052130.61374404
121Shigellosis_Homo sapiens_hsa051310.61123552
122Apoptosis_Homo sapiens_hsa042100.60964068
123Chronic myeloid leukemia_Homo sapiens_hsa052200.59463309
124Axon guidance_Homo sapiens_hsa043600.59113297
125Adipocytokine signaling pathway_Homo sapiens_hsa049200.58643785
126Ras signaling pathway_Homo sapiens_hsa040140.58552599
127AMPK signaling pathway_Homo sapiens_hsa041520.57992333
128Insulin resistance_Homo sapiens_hsa049310.56215466
129Renal cell carcinoma_Homo sapiens_hsa052110.55385725
130Leishmaniasis_Homo sapiens_hsa051400.54468370
131Melanogenesis_Homo sapiens_hsa049160.54384525
132Pathways in cancer_Homo sapiens_hsa052000.53402529
133Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.52736891
134African trypanosomiasis_Homo sapiens_hsa051430.52447895
135HIF-1 signaling pathway_Homo sapiens_hsa040660.52388487
136Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.51398856
137Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.50919979
138Transcriptional misregulation in cancer_Homo sapiens_hsa052020.50442686

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