TBK1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The NF-kappa-B (NFKB) complex of proteins is inhibited by I-kappa-B (IKB) proteins, which inactivate NFKB by trapping it in the cytoplasm. Phosphorylation of serine residues on the IKB proteins by IKB kinases marks them for destruction via the ubiquitination pathway, thereby allowing activation and nuclear translocation of the NFKB complex. The protein encoded by this gene is similar to IKB kinases and can mediate NFKB activation in response to certain growth factors. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G6.31932786
2positive regulation of gamma-delta T cell activation (GO:0046645)5.09957511
3* positive regulation of interferon-alpha production (GO:0032727)4.61262126
4positive regulation by symbiont of host defense response (GO:0052509)4.50093373
5modulation by symbiont of host defense response (GO:0052031)4.50093373
6modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.50093373
7modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.50093373
8positive regulation by organism of defense response of other organism involved in symbiotic interact4.50093373
9modulation by symbiont of host immune response (GO:0052553)4.50093373
10neutrophil activation involved in immune response (GO:0002283)4.41495867
11* regulation of interferon-alpha production (GO:0032647)4.40629825
12antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.32594176
13antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.32594176
14antigen processing and presentation of endogenous antigen (GO:0019883)4.18321868
15regulation of B cell receptor signaling pathway (GO:0050855)4.15989460
16immunoglobulin mediated immune response (GO:0016064)4.10894425
17* regulation of interferon-beta biosynthetic process (GO:0045357)4.06087673
18response to type I interferon (GO:0034340)4.04292552
19type I interferon signaling pathway (GO:0060337)4.00118931
20cellular response to type I interferon (GO:0071357)4.00118931
21positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.96133837
22ribosome assembly (GO:0042255)3.88109837
23positive regulation of B cell differentiation (GO:0045579)3.80915293
24cellular response to interferon-beta (GO:0035458)3.65381875
25interferon-gamma-mediated signaling pathway (GO:0060333)3.57355788
26regulation of interleukin-12 biosynthetic process (GO:0045075)3.56941647
27response to peptidoglycan (GO:0032494)3.49875957
28macrophage activation involved in immune response (GO:0002281)3.49745492
29nuclear pore complex assembly (GO:0051292)3.45976517
30regulation of gamma-delta T cell differentiation (GO:0045586)3.45653481
31regulation of gamma-delta T cell activation (GO:0046643)3.44187870
32regulation of B cell differentiation (GO:0045577)3.39440676
33defense response to protozoan (GO:0042832)3.38495342
34B cell mediated immunity (GO:0019724)3.38477882
35negative regulation of cell killing (GO:0031342)3.37716469
36negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.37716469
37* positive regulation of interferon-beta production (GO:0032728)3.36734565
38proteasome assembly (GO:0043248)3.32374162
39positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.29906011
40granulocyte activation (GO:0036230)3.29823733
41leukocyte aggregation (GO:0070486)3.29373372
42regulation of nitric-oxide synthase biosynthetic process (GO:0051769)3.27900284
43B cell receptor signaling pathway (GO:0050853)3.27386791
44neutrophil activation (GO:0042119)3.25368373
45cellular response to exogenous dsRNA (GO:0071360)3.24328944
46regulation of alpha-beta T cell proliferation (GO:0046640)3.23118434
47hepatocyte apoptotic process (GO:0097284)3.21571388
48response to interferon-beta (GO:0035456)3.21194337
49positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.21132758
50natural killer cell mediated immunity (GO:0002228)3.18221476
51natural killer cell mediated cytotoxicity (GO:0042267)3.18221476
52myeloid cell activation involved in immune response (GO:0002275)3.17032531
53myeloid dendritic cell activation (GO:0001773)3.16565808
54regulation of syncytium formation by plasma membrane fusion (GO:0060142)3.16065726
55positive regulation of alpha-beta T cell proliferation (GO:0046641)3.14764691
56lipopolysaccharide-mediated signaling pathway (GO:0031663)3.14090475
57NIK/NF-kappaB signaling (GO:0038061)3.13309283
58response to muramyl dipeptide (GO:0032495)3.11578133
59nuclear pore organization (GO:0006999)3.11189771
60regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.10870971
61response to interferon-alpha (GO:0035455)3.08419019
62regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.05417568
63myeloid dendritic cell differentiation (GO:0043011)3.04696180
64negative regulation of interleukin-17 production (GO:0032700)3.04014915
65respiratory burst (GO:0045730)3.02121569
66regulation of ER to Golgi vesicle-mediated transport (GO:0060628)3.01419780
67response to protozoan (GO:0001562)3.00969406
68response to host immune response (GO:0052572)2.99644889
69response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.99644889
70regulation of type I interferon-mediated signaling pathway (GO:0060338)2.96360231
71germinal center formation (GO:0002467)2.95668308
72regulation of T-helper 1 cell differentiation (GO:0045625)2.93906007
73regulation of RIG-I signaling pathway (GO:0039535)2.92952833
74positive regulation of interleukin-12 production (GO:0032735)2.92227739
75necroptotic process (GO:0070266)2.90900470
76negative thymic T cell selection (GO:0045060)2.90583282
77JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.87671052
78positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.87537384
79positive regulation of cellular amide metabolic process (GO:0034250)2.85113082
80T cell migration (GO:0072678)2.85043760
81histone mRNA catabolic process (GO:0071044)2.84928980
82Arp2/3 complex-mediated actin nucleation (GO:0034314)2.83704387
83antigen processing and presentation via MHC class Ib (GO:0002475)2.82980259
84pore complex assembly (GO:0046931)2.82372678
85production of molecular mediator involved in inflammatory response (GO:0002532)2.82105516
86negative regulation of viral genome replication (GO:0045071)2.81082474
87response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.79538803
88response to host (GO:0075136)2.79538803
89response to host defenses (GO:0052200)2.79538803
90T-helper 1 type immune response (GO:0042088)2.79518436
91positive regulation of humoral immune response (GO:0002922)2.78855966
92negative T cell selection (GO:0043383)2.78374889
93regulation of T cell receptor signaling pathway (GO:0050856)2.77699133
94positive regulation of defense response to virus by host (GO:0002230)2.77101771
95positive regulation of macrophage differentiation (GO:0045651)2.76779093
96mature B cell differentiation (GO:0002335)2.75217953
97positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.74924778
98leukocyte cell-cell adhesion (GO:0007159)2.73388744
99positive regulation of chemokine biosynthetic process (GO:0045080)2.73049473
100cellular response to zinc ion (GO:0071294)2.73038029
101somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.71329823
102isotype switching (GO:0045190)2.71329823
103somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.71329823
104histamine secretion (GO:0001821)2.71205979
105mast cell activation (GO:0045576)2.70920234
106regulation of response to interferon-gamma (GO:0060330)2.70659055
107positive regulation of antigen processing and presentation (GO:0002579)2.70012720
108mitotic G2 DNA damage checkpoint (GO:0007095)2.68980727
109neutrophil mediated immunity (GO:0002446)2.68121580
110cellular response to interferon-gamma (GO:0071346)2.67769584
111myeloid leukocyte activation (GO:0002274)2.67628701
112positive regulation of response to biotic stimulus (GO:0002833)2.67012293
113positive regulation of mast cell activation (GO:0033005)2.66895956
114positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.66809736
115regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.66578599
116positive regulation of natural killer cell differentiation (GO:0032825)2.64165977
117regulation of centriole replication (GO:0046599)2.64105570
118positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.60986671
119DNA double-strand break processing (GO:0000729)2.60320582
120dendritic cell differentiation (GO:0097028)2.59308786
121negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.58520833
122protein K6-linked ubiquitination (GO:0085020)2.57591325
123detection of molecule of bacterial origin (GO:0032490)2.55504961
124negative regulation of interleukin-12 production (GO:0032695)2.54340412
125positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.53731823
126positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.53731823
127positive regulation of mitotic sister chromatid separation (GO:1901970)2.53731823
128regulation of cytokine secretion involved in immune response (GO:0002739)2.52121554
129eosinophil chemotaxis (GO:0048245)2.51907496
130mitotic G2/M transition checkpoint (GO:0044818)2.49602424
131regulation of vitamin D biosynthetic process (GO:0060556)2.47972599
132anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.44329666
133antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.43520441
134metaphase plate congression (GO:0051310)2.43323768
135establishment of chromosome localization (GO:0051303)2.43060573
136rRNA methylation (GO:0031167)2.41922480
137iron ion import (GO:0097286)2.40700970
138antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.40173573
139negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.38209384
140negative regulation of ligase activity (GO:0051352)2.38209384
141B cell activation involved in immune response (GO:0002312)2.34663170
142negative regulation of B cell proliferation (GO:0030889)2.34435492
143antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.33424225
144regulation of interferon-gamma-mediated signaling pathway (GO:0060334)2.31189040
145DNA deamination (GO:0045006)2.30869377
146negative regulation of NF-kappaB import into nucleus (GO:0042347)2.30657657
147DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.28195450
148cytidine deamination (GO:0009972)2.26849924
149cytidine metabolic process (GO:0046087)2.26849924
150cytidine catabolic process (GO:0006216)2.26849924
151intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.26649228
152signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.26649228
153cellular response to interferon-alpha (GO:0035457)2.25615614
154mitotic metaphase plate congression (GO:0007080)2.25338179
155signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.25271083
156signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.25271083
157signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.25271083
158positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.23925459
159cellular response to ethanol (GO:0071361)2.21647510
160RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.21355811
161regulation of cellular amino acid metabolic process (GO:0006521)2.19378964
162regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.18906622
163regulation of mitotic metaphase/anaphase transition (GO:0030071)2.18906622
164eosinophil migration (GO:0072677)2.18629015
165signal transduction involved in DNA damage checkpoint (GO:0072422)2.17922181
166signal transduction involved in DNA integrity checkpoint (GO:0072401)2.17922181
167positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.16011329
168attachment of spindle microtubules to kinetochore (GO:0008608)2.14860797
169signal transduction involved in cell cycle checkpoint (GO:0072395)2.13622383
170regulation of viral genome replication (GO:0045069)2.13020574

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human6.43789947
2IRF8_21731497_ChIP-ChIP_J774_Mouse5.43088737
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.59408005
4* IRF8_22096565_ChIP-ChIP_GC-B_Mouse4.23308627
5BP1_19119308_ChIP-ChIP_Hs578T_Human4.20449088
6STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.00155161
7IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.82046712
8GATA1_22025678_ChIP-Seq_K562_Human3.72573212
9MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.70795042
10IRF8_27001747_Chip-Seq_BMDM_Mouse3.62499861
11SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.43661015
12E2F7_22180533_ChIP-Seq_HELA_Human3.34004868
13* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.22242697
14MYB_21317192_ChIP-Seq_ERMYB_Mouse3.05958920
15EGR1_19374776_ChIP-ChIP_THP-1_Human3.03773044
16KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.93850067
17STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.84576119
18SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.76148893
19Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.71079031
20* ELK1_19687146_ChIP-ChIP_HELA_Human2.69221991
21GABP_17652178_ChIP-ChIP_JURKAT_Human2.68729528
22STAT4_19710469_ChIP-ChIP_TH1__Mouse2.65203305
23NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.39887008
24MYB_26560356_Chip-Seq_TH2_Human2.27053116
25SCL_19346495_ChIP-Seq_HPC-7_Human2.24814675
26* PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.23481122
27RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.19908106
28RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.16861739
29SPI1_23547873_ChIP-Seq_NB4_Human2.09470306
30* ASXL1_24218140_ChIP-Seq_BMDM_Mouse2.07846819
31EST1_17652178_ChIP-ChIP_JURKAT_Human2.07143241
32* PADI4_21655091_ChIP-ChIP_MCF-7_Human2.05671336
33VDR_23849224_ChIP-Seq_CD4+_Human2.04045005
34* BRD4_27068464_Chip-Seq_AML-cells_Mouse2.03941127
35SALL1_21062744_ChIP-ChIP_HESCs_Human2.03094803
36RUNX_20019798_ChIP-Seq_JUKART_Human2.01820379
37MYB_26560356_Chip-Seq_TH1_Human1.99677096
38SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.97933836
39NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.93894924
40FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.92226297
41FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.90919789
42MAF_26560356_Chip-Seq_TH1_Human1.85636246
43CREB1_15753290_ChIP-ChIP_HEK293T_Human1.82925772
44RUNX1_22412390_ChIP-Seq_EML_Mouse1.81633425
45KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.75058969
46* PU_27001747_Chip-Seq_BMDM_Mouse1.71883033
47FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.70842767
48SPI1_23127762_ChIP-Seq_K562_Human1.70629212
49POU3F2_20337985_ChIP-ChIP_501MEL_Human1.69841605
50NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.63376278
51FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.61698975
52VDR_24763502_ChIP-Seq_THP-1_Human1.60602572
53MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.58915747
54MYC_22102868_ChIP-Seq_BL_Human1.58191657
55VDR_21846776_ChIP-Seq_THP-1_Human1.57611707
56STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.56017607
57FOXP3_21729870_ChIP-Seq_TREG_Human1.55728115
58CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.55463401
59PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.51608073
60FOXM1_23109430_ChIP-Seq_U2OS_Human1.51310577
61FLI1_27457419_Chip-Seq_LIVER_Mouse1.49708792
62STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.47594315
63GATA2_22383799_ChIP-Seq_G1ME_Mouse1.46801195
64AR_21909140_ChIP-Seq_LNCAP_Human1.45818312
65PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.43073218
66* GATA3_27048872_Chip-Seq_THYMUS_Human1.41803569
67LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.40490756
68DCP1A_22483619_ChIP-Seq_HELA_Human1.40343732
69UTX_26944678_Chip-Seq_JUKART_Human1.39774827
70CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.38239633
71GATA3_26560356_Chip-Seq_TH2_Human1.35619316
72SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.33990159
73SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.33942462
74E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.33093093
75CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.31165773
76NELFA_20434984_ChIP-Seq_ESCs_Mouse1.30238673
77MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.25972949
78GATA2_21666600_ChIP-Seq_HMVEC_Human1.24339341
79LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.23490029
80HOXB4_20404135_ChIP-ChIP_EML_Mouse1.22582439
81TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.22311699
82TCF7_22412390_ChIP-Seq_EML_Mouse1.21188187
83SMAD_19615063_ChIP-ChIP_OVARY_Human1.20171025
84SRF_21415370_ChIP-Seq_HL-1_Mouse1.19790489
85* TFEB_21752829_ChIP-Seq_HELA_Human1.19635349
86* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.18884167
87GATA1_19941827_ChIP-Seq_MEL_Mouse1.17511578
88JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.17232086
89TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.16607897
90HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.16464998
91* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.16258690
92VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.15881533
93CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.15608238
94ER_23166858_ChIP-Seq_MCF-7_Human1.15464678
95GATA1_22383799_ChIP-Seq_G1ME_Mouse1.13102342
96ELF5_23300383_ChIP-Seq_T47D_Human1.13046156
97E2F1_21310950_ChIP-Seq_MCF-7_Human1.12463383
98ETS1_20019798_ChIP-Seq_JURKAT_Human1.11179172
99* CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.10697047
100GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.09817736
101VDR_24787735_ChIP-Seq_THP-1_Human1.09719039
102TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.09588691
103EZH2_27294783_Chip-Seq_NPCs_Mouse1.09260321
104ELF1_17652178_ChIP-ChIP_JURKAT_Human1.08607807
105ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.08588383
106RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.07423243
107PCGF2_27294783_Chip-Seq_ESCs_Mouse1.06356239
108ERG_20887958_ChIP-Seq_HPC-7_Mouse1.05851153
109CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.03663681
110PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.03429980
111NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.02471487
112MYC_19030024_ChIP-ChIP_MESCs_Mouse1.01100974
113EGR1_23403033_ChIP-Seq_LIVER_Mouse1.00778261
114SUZ12_27294783_Chip-Seq_NPCs_Mouse0.99697354
115SALL4_22934838_ChIP-ChIP_CD34+_Human0.99409042
116YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.97145959
117HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.96829309
118SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.96171391
119EWS_26573619_Chip-Seq_HEK293_Human0.96049107
120NFE2_27457419_Chip-Seq_LIVER_Mouse0.95469052
121E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.95332404
122MAF_26560356_Chip-Seq_TH2_Human0.95294114
123FUS_26573619_Chip-Seq_HEK293_Human0.92996934
124* GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.92995509
125BRD4_25478319_ChIP-Seq_HGPS_Human0.92346791
126E2F1_18555785_ChIP-Seq_MESCs_Mouse0.92230011
127CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.92145444
128GATA2_19941826_ChIP-Seq_K562_Human0.92077553
129RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.91220753
130NOTCH1_21737748_ChIP-Seq_TLL_Human0.91205194
131FOXM1_26456572_ChIP-Seq_MCF-7_Human0.90783884
132SALL4_18804426_ChIP-ChIP_XEN_Mouse0.90476908
133* CDX2_22108803_ChIP-Seq_LS180_Human0.89846839
134THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.89395812
135AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.89125016
136* GABP_19822575_ChIP-Seq_HepG2_Human0.88704799
137* CRX_20693478_ChIP-Seq_RETINA_Mouse0.88521890
138* SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.87273936
139PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.86692916
140GATA1_19941826_ChIP-Seq_K562_Human0.86042711
141CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.85370533
142SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.84930822
143CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.80910170
144GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.80228744
145PU.1_20513432_ChIP-Seq_Bcells_Mouse0.79574832
146PPARA_22158963_ChIP-Seq_LIVER_Mouse0.78049407
147SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.77951174
148KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.77009967
149CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.76456588
150CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.76065507
151PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.76020951
152FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.73897696
153RXR_22158963_ChIP-Seq_LIVER_Mouse0.72656797
154ETS1_22383799_ChIP-Seq_G1ME_Mouse0.72642360
155E2F4_17652178_ChIP-ChIP_JURKAT_Human0.69867604
156ELK3_25401928_ChIP-Seq_HUVEC_Human0.67956252
157KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.67823236
158LXR_22158963_ChIP-Seq_LIVER_Mouse0.67492021

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.33066297
2* MP0009785_altered_susceptibility_to3.33759893
3MP0003436_decreased_susceptibility_to3.06002368
4MP0005671_abnormal_response_to3.00254784
5MP0000685_abnormal_immune_system2.90290615
6MP0003806_abnormal_nucleotide_metabolis2.86889736
7MP0005000_abnormal_immune_tolerance2.79822356
8MP0002419_abnormal_innate_immunity2.77534534
9MP0001790_abnormal_immune_system2.74792117
10MP0005387_immune_system_phenotype2.74792117
11* MP0001800_abnormal_humoral_immune2.71000480
12* MP0005025_abnormal_response_to2.69220066
13MP0002148_abnormal_hypersensitivity_rea2.66375691
14MP0006082_CNS_inflammation2.63537898
15* MP0002452_abnormal_antigen_presenting2.60907293
16* MP0002723_abnormal_immune_serum2.52862298
17MP0003724_increased_susceptibility_to2.46283975
18MP0002166_altered_tumor_susceptibility2.44625507
19MP0005464_abnormal_platelet_physiology2.43291156
20* MP0001819_abnormal_immune_cell2.36776991
21* MP0002420_abnormal_adaptive_immunity2.34689717
22MP0002006_tumorigenesis2.29087271
23MP0000569_abnormal_digit_pigmentation2.20239731
24MP0003303_peritoneal_inflammation2.17830158
25MP0005058_abnormal_lysosome_morphology2.15298334
26MP0010094_abnormal_chromosome_stability2.02320414
27* MP0002398_abnormal_bone_marrow2.02081551
28MP0010234_abnormal_vibrissa_follicle2.00377060
29MP0001853_heart_inflammation1.91528070
30MP0003195_calcinosis1.89527046
31MP0004510_myositis1.88214109
32MP0000372_irregular_coat_pigmentation1.87086067
33* MP0000716_abnormal_immune_system1.86552985
34* MP0004947_skin_inflammation1.84500175
35MP0003191_abnormal_cellular_cholesterol1.80456804
36MP0005397_hematopoietic_system_phenotyp1.80440103
37MP0001545_abnormal_hematopoietic_system1.80440103
38MP0003172_abnormal_lysosome_physiology1.79001860
39MP0002405_respiratory_system_inflammati1.78834439
40MP0010155_abnormal_intestine_physiology1.78580360
41MP0004957_abnormal_blastocyst_morpholog1.75737787
42* MP0001845_abnormal_inflammatory_respons1.74936811
43MP0008007_abnormal_cellular_replicative1.72044775
44* MP0000689_abnormal_spleen_morphology1.71579334
45MP0003763_abnormal_thymus_physiology1.70885674
46MP0001533_abnormal_skeleton_physiology1.70135107
47MP0003183_abnormal_peptide_metabolism1.67422600
48MP0002396_abnormal_hematopoietic_system1.66350757
49MP0008058_abnormal_DNA_repair1.64173412
50* MP0008469_abnormal_protein_level1.63332512
51MP0003300_gastrointestinal_ulcer1.61587046
52MP0008260_abnormal_autophagy1.60785809
53MP0009764_decreased_sensitivity_to1.60711536
54* MP0002429_abnormal_blood_cell1.58445906
55MP0001873_stomach_inflammation1.57718216
56* MP0002722_abnormal_immune_system1.57535098
57MP0005451_abnormal_body_composition1.54578117
58MP0003221_abnormal_cardiomyocyte_apopto1.53799601
59MP0003111_abnormal_nucleus_morphology1.53004029
60MP0005075_abnormal_melanosome_morpholog1.52251601
61MP0003077_abnormal_cell_cycle1.45328643
62MP0009333_abnormal_splenocyte_physiolog1.45209309
63MP0004808_abnormal_hematopoietic_stem1.44697203
64MP0003656_abnormal_erythrocyte_physiolo1.44206711
65MP0002254_reproductive_system_inflammat1.41957264
66MP0003693_abnormal_embryo_hatching1.40506622
67MP0003786_premature_aging1.39535282
68MP0009278_abnormal_bone_marrow1.39478137
69MP0010307_abnormal_tumor_latency1.38527286
70MP0005310_abnormal_salivary_gland1.38324332
71MP0003448_altered_tumor_morphology1.36578068
72MP0005408_hypopigmentation1.34223424
73MP0003950_abnormal_plasma_membrane1.32669019
74MP0000604_amyloidosis1.29994557
75MP0009840_abnormal_foam_cell1.29358840
76MP0000343_altered_response_to1.26071583
77MP0000858_altered_metastatic_potential1.21340764
78MP0008877_abnormal_DNA_methylation1.20141493
79MP0003075_altered_response_to1.15963975
80MP0005174_abnormal_tail_pigmentation1.15352550
81MP0002998_abnormal_bone_remodeling1.11641306
82MP0010352_gastrointestinal_tract_polyps1.09186573
83MP0003866_abnormal_defecation1.08046821
84MP0010678_abnormal_skin_adnexa1.07724383
85MP0000703_abnormal_thymus_morphology1.07705994
86MP0000465_gastrointestinal_hemorrhage1.06779140
87MP0009763_increased_sensitivity_to1.05637539
88MP0000358_abnormal_cell_content/1.05354187
89MP0005166_decreased_susceptibility_to1.03708261
90MP0002138_abnormal_hepatobiliary_system1.03683598
91MP0003941_abnormal_skin_development1.00381138
92MP0002332_abnormal_exercise_endurance0.98954300
93MP0000371_diluted_coat_color0.98526333
94MP0003045_fibrosis0.97638376
95MP0000015_abnormal_ear_pigmentation0.97464835
96MP0005360_urolithiasis0.96675454
97MP0005167_abnormal_blood-brain_barrier0.94071870
98MP0006035_abnormal_mitochondrial_morpho0.91111626
99MP0000490_abnormal_crypts_of0.91068947
100MP0008057_abnormal_DNA_replication0.90625003
101MP0000609_abnormal_liver_physiology0.88855814
102MP0006036_abnormal_mitochondrial_physio0.88422829
103* MP0000427_abnormal_hair_cycle0.87476048
104MP0003566_abnormal_cell_adhesion0.84546010
105MP0005621_abnormal_cell_physiology0.82321214
106MP0002019_abnormal_tumor_incidence0.81607659
107MP0002933_joint_inflammation0.81490025
108MP0004883_abnormal_blood_vessel0.81121785
109* MP0001191_abnormal_skin_condition0.80271183
110MP0002009_preneoplasia0.78721689
111MP0003091_abnormal_cell_migration0.78090073
112MP0005384_cellular_phenotype0.77936075
113MP0003943_abnormal_hepatobiliary_system0.76127765
114MP0002877_abnormal_melanocyte_morpholog0.75954814
115MP0009697_abnormal_copulation0.75296683
116MP0002090_abnormal_vision0.74579151
117MP0009765_abnormal_xenobiotic_induced0.74239966
118MP0004147_increased_porphyrin_level0.72772282
119* MP0000598_abnormal_liver_morphology0.72162992
120MP0000249_abnormal_blood_vessel0.71741844
121MP0002139_abnormal_hepatobiliary_system0.70114656
122MP0005319_abnormal_enzyme/_coenzyme0.69075077
123MP0003186_abnormal_redox_activity0.68858979
124MP0006054_spinal_hemorrhage0.68403656
125MP0005164_abnormal_response_to0.65504063
126MP0008873_increased_physiological_sensi0.64346291
127MP0010329_abnormal_lipoprotein_level0.63876110
128MP0004264_abnormal_extraembryonic_tissu0.62896728
129MP0005023_abnormal_wound_healing0.62693806
130MP0005390_skeleton_phenotype0.61350548
131MP0003828_pulmonary_edema0.60600031
132MP0002136_abnormal_kidney_physiology0.59838137
133MP0003252_abnormal_bile_duct0.59493103
134MP0005584_abnormal_enzyme/coenzyme_acti0.59301811

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)5.64832084
2Recurrent bacterial skin infections (HP:0005406)5.40755475
3Myositis (HP:0100614)4.74820055
4Eczematoid dermatitis (HP:0000976)4.70592146
5Autoimmune thrombocytopenia (HP:0001973)4.66723150
6Elevated erythrocyte sedimentation rate (HP:0003565)4.51472373
7Recurrent gram-negative bacterial infections (HP:0005420)4.33439971
8Mediastinal lymphadenopathy (HP:0100721)4.13729695
9Recurrent viral infections (HP:0004429)3.87947407
10Recurrent fungal infections (HP:0002841)3.61510905
11Abnormality of macrophages (HP:0004311)3.58601135
12Increased cerebral lipofuscin (HP:0011813)3.46755431
13Optic neuritis (HP:0100653)3.46193447
14Retrobulbar optic neuritis (HP:0100654)3.46193447
15Recurrent skin infections (HP:0001581)3.41413906
16Orchitis (HP:0100796)3.39104365
17Vasculitis (HP:0002633)3.38311294
18Increased neuronal autofluorescent lipopigment (HP:0002074)3.33063121
19Pustule (HP:0200039)3.29412886
20Vacuolated lymphocytes (HP:0001922)3.23628816
21Chronic otitis media (HP:0000389)3.18021127
22Stomatitis (HP:0010280)3.15531409
23Thrombocytosis (HP:0001894)3.13834798
24Arterial thrombosis (HP:0004420)3.12364223
25Autoimmune hemolytic anemia (HP:0001890)3.01419286
26Abnormality of chromosome stability (HP:0003220)2.95640103
27Abnormality of T cell number (HP:0011839)2.82767755
28Tetraparesis (HP:0002273)2.80978658
29Periodontitis (HP:0000704)2.80837456
30IgM deficiency (HP:0002850)2.79674378
31Systemic lupus erythematosus (HP:0002725)2.78004940
32Pulmonary infiltrates (HP:0002113)2.76646860
33Gingival bleeding (HP:0000225)2.74737091
34Meningitis (HP:0001287)2.70080688
35Abnormality of the prostate (HP:0008775)2.67627269
36Prostate neoplasm (HP:0100787)2.64961704
37Recurrent bronchitis (HP:0002837)2.64492972
38Gingivitis (HP:0000230)2.64285608
39T lymphocytopenia (HP:0005403)2.64052180
40Increased IgM level (HP:0003496)2.59844995
41Petechiae (HP:0000967)2.59065614
42Leukocytosis (HP:0001974)2.58272536
43Papillary thyroid carcinoma (HP:0002895)2.56687345
44Osteomyelitis (HP:0002754)2.56094590
45Chronic mucocutaneous candidiasis (HP:0002728)2.54037708
46Recurrent cutaneous fungal infections (HP:0011370)2.54037708
47Keratoconjunctivitis sicca (HP:0001097)2.53699219
48Thyroiditis (HP:0100646)2.53683029
49Epistaxis (HP:0000421)2.50927348
50Obstructive lung disease (HP:0006536)2.50715400
51Chronic obstructive pulmonary disease (HP:0006510)2.50715400
52Interstitial pulmonary disease (HP:0006530)2.47991218
53Disinhibition (HP:0000734)2.47271403
54Abnormality of T cells (HP:0002843)2.46691304
55Abnormality of the fingertips (HP:0001211)2.46612391
56Cellulitis (HP:0100658)2.45665231
57Eosinophilia (HP:0001880)2.43167200
58Albinism (HP:0001022)2.42948869
59Abnormality of glycolipid metabolism (HP:0010969)2.42055690
60Abnormality of liposaccharide metabolism (HP:0010968)2.42055690
61Abnormality of glycosphingolipid metabolism (HP:0004343)2.42055690
62Myelodysplasia (HP:0002863)2.38659692
63Lymphopenia (HP:0001888)2.37494245
64Basal ganglia calcification (HP:0002135)2.37214948
65Abnormality of cells of the lymphoid lineage (HP:0012140)2.35342665
66Agnosia (HP:0010524)2.35268588
67Chronic diarrhea (HP:0002028)2.33722381
68Abnormality of B cell number (HP:0010975)2.33074036
69B lymphocytopenia (HP:0010976)2.33074036
70Joint swelling (HP:0001386)2.30087848
71Hypoplasia of the thymus (HP:0000778)2.30082679
72IgA deficiency (HP:0002720)2.28612934
73Hemoptysis (HP:0002105)2.27962438
74Severe combined immunodeficiency (HP:0004430)2.27208283
75Keratoconjunctivitis (HP:0001096)2.27036362
76Combined immunodeficiency (HP:0005387)2.25487164
77IgG deficiency (HP:0004315)2.23348354
78Hematochezia (HP:0002573)2.23185349
79Thyroid carcinoma (HP:0002890)2.22645496
80Abnormality of methionine metabolism (HP:0010901)2.22617792
81Chromosomal breakage induced by crosslinking agents (HP:0003221)2.22029238
82Abnormality of T cell physiology (HP:0011840)2.19859995
83Dyschromatopsia (HP:0007641)2.18685710
84Gastrointestinal stroma tumor (HP:0100723)2.18643376
85Prolonged bleeding time (HP:0003010)2.17907664
86Panhypogammaglobulinemia (HP:0003139)2.17861700
87Hypergammaglobulinemia (HP:0010702)2.17384236
88Abnormality of eosinophils (HP:0001879)2.17182991
89Amaurosis fugax (HP:0100576)2.16250261
90Chest pain (HP:0100749)2.15995606
91Encephalitis (HP:0002383)2.15217859
92Gastrointestinal infarctions (HP:0005244)2.14651627
93Granulocytopenia (HP:0001913)2.14598680
94Cutaneous melanoma (HP:0012056)2.13266678
95Abnormal platelet function (HP:0011869)2.11524674
96Impaired platelet aggregation (HP:0003540)2.11524674
97Spontaneous hematomas (HP:0007420)2.09895110
98Abnormal platelet volume (HP:0011876)2.09707013
99Autoamputation (HP:0001218)2.09690989
100Abnormality of the preputium (HP:0100587)2.09182907
101Upper motor neuron abnormality (HP:0002127)2.09090281
102Loss of speech (HP:0002371)2.08958496
103Entropion (HP:0000621)2.06107609
104Acute hepatic failure (HP:0006554)2.05626938
105Urticaria (HP:0001025)2.04186016
106Volvulus (HP:0002580)2.03236052
107Recurrent pneumonia (HP:0006532)2.02516783
108Rhabdomyosarcoma (HP:0002859)2.01862114
109Abnormal protein glycosylation (HP:0012346)2.01539845
110Abnormal glycosylation (HP:0012345)2.01539845
111Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.01539845
112Abnormal protein N-linked glycosylation (HP:0012347)2.01539845
113Anorexia (HP:0002039)2.00730722
114Agammaglobulinemia (HP:0004432)2.00714830
115Chromsome breakage (HP:0040012)1.99831555
116Arthralgia (HP:0002829)1.97916746
117Degeneration of anterior horn cells (HP:0002398)1.97735708
118Abnormality of the anterior horn cell (HP:0006802)1.97735708
119Dysostosis multiplex (HP:0000943)1.97544253
120Myocardial infarction (HP:0001658)1.97364104
121Freckling (HP:0001480)1.94621749
122Abnormal delayed hypersensitivity skin test (HP:0002963)1.94411031
123Acute myeloid leukemia (HP:0004808)1.93353531
124Vertebral compression fractures (HP:0002953)1.93192288
125Lymphoma (HP:0002665)1.92819496
126Abnormal spermatogenesis (HP:0008669)1.92680147
127Thrombophlebitis (HP:0004418)1.92241922
128Increased mean platelet volume (HP:0011877)1.91051905
129Colitis (HP:0002583)1.91016745
130Posterior subcapsular cataract (HP:0007787)1.88145490
131Aplasia/Hypoplasia of the uvula (HP:0010293)1.85590804
132Breast carcinoma (HP:0003002)1.84983542
133Hypobetalipoproteinemia (HP:0003563)1.84051770
134Gangrene (HP:0100758)1.82191129
135Abnormality of aspartate family amino acid metabolism (HP:0010899)1.81760168
136Prominent nose (HP:0000448)1.80866548
137Increased hepatocellular lipid droplets (HP:0006565)1.80864464
138Progressive external ophthalmoplegia (HP:0000590)1.78683657
139Clubbing of toes (HP:0100760)1.78216625
140Deep philtrum (HP:0002002)1.77172580
141Fatigue (HP:0012378)1.74638185
142Neoplasm of the tracheobronchial system (HP:0100552)1.74265473
143Hypochromic microcytic anemia (HP:0004840)1.73699916
144Osteolytic defects of the hand bones (HP:0009699)1.73328024
145Osteolytic defects of the phalanges of the hand (HP:0009771)1.73328024
146Biliary tract neoplasm (HP:0100574)1.73056054
147Lipid accumulation in hepatocytes (HP:0006561)1.73007803
148Ascites (HP:0001541)1.72947092
149Progressive neurologic deterioration (HP:0002344)1.72825954
150Micronodular cirrhosis (HP:0001413)1.72132877
151Alveolar cell carcinoma (HP:0006519)1.70738312
152Duodenal stenosis (HP:0100867)1.70100163
153Small intestinal stenosis (HP:0012848)1.70100163
154Polyneuropathy (HP:0001271)1.69573361
155Meckel diverticulum (HP:0002245)1.67455798
156Type I transferrin isoform profile (HP:0003642)1.67359667
157Viral hepatitis (HP:0006562)1.66716979
158Facial diplegia (HP:0001349)1.66694109

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EIF2AK34.42237896
2MAP4K13.75303696
3RIPK43.72966820
4TYK23.44978709
5MAP3K143.40441670
6EIF2AK13.34971416
7TRIM283.33690822
8KIT3.24213690
9JAK32.98983300
10* TBK12.94648483
11IKBKE2.75985171
12TXK2.69816646
13PBK2.54154216
14JAK12.38980316
15CSF1R2.19481970
16ERBB32.18274916
17BUB12.17625272
18NUAK12.10259680
19ZAP702.09530718
20IRAK42.09245717
21MAP3K132.00623854
22PDK21.98293665
23SYK1.95650906
24WEE11.86999252
25TEC1.86170781
26MAP2K31.83878503
27BCR1.77077606
28IKBKB1.76025697
29MAP4K21.73542907
30TAOK31.71997759
31PLK41.65894767
32BTK1.62925099
33FGFR41.62280685
34NEK11.60253107
35BMPR1B1.59576331
36FLT31.59254553
37BLK1.52617761
38IRAK31.49595768
39STK101.49259821
40LCK1.48371158
41TTK1.44534063
42ITK1.43214084
43FGFR31.43124646
44NEK91.35203652
45PLK31.29217738
46FRK1.27296865
47SRPK11.26542593
48EIF2AK21.25707963
49CHUK1.25226358
50HCK1.24012443
51SIK31.17021802
52GRK61.16221205
53LYN1.15402836
54JAK21.14929659
55ERN11.14653394
56MAP3K121.13609911
57PIM11.11056027
58TRPM71.10403333
59CLK11.07514224
60CSK1.07206744
61MATK1.06787207
62MKNK21.06579803
63TGFBR21.05235491
64STK38L1.01852410
65PIM20.99705221
66RIPK10.99370989
67FES0.95907123
68MST40.95089859
69BRD40.92760587
70DAPK10.89798718
71PKN20.88998872
72MAP3K60.84035197
73EEF2K0.83417202
74MKNK10.79805986
75MARK30.78071298
76STK40.76721663
77GRK70.75872987
78LRRK20.74463169
79CCNB10.74312252
80YES10.73674703
81ACVR1B0.73292960
82PAK40.73046009
83TNK20.69912441
84CDK60.68911697
85PTK60.68243876
86PLK10.64909454
87ERBB40.64743427
88SCYL20.62839036
89FGR0.62256947
90AKT30.61431750
91SGK30.60932971
92STK30.60557222
93EGFR0.60097525
94MST1R0.59984206
95ADRBK20.59304121
96FER0.59077382
97ZAK0.58604630
98TSSK60.55598313
99MAP3K50.55241214
100OXSR10.53119557
101SIK20.52396858
102CDK80.52207241
103BRSK10.50449864
104PDK10.50336492
105CAMK1D0.49986509
106CAMKK20.49815672
107PRKCD0.49628160
108NEK60.49444065
109PIK3CG0.48883325
110RPS6KA40.48742207
111TGFBR10.47980461
112KSR10.47361153
113TTN0.45969956
114PRKCQ0.45958083
115CSNK1G30.44330365
116IGF1R0.44282919
117PLK20.42949540
118ABL10.42859601
119CSNK1A1L0.41436456
120BMX0.41319720
121PTK2B0.41030346
122CDK120.41029326
123MAPK110.40213947
124ATR0.39467042
125PRKG20.39384236
126PRKCH0.38041875
127CDK40.37689207
128DYRK30.37476053
129ATM0.37052953
130CSNK1G20.36258932
131CSNK1G10.36049992
132TAF10.36017739
133RPS6KB20.35489921
134BMPR20.35426653
135SGK20.34756803
136NME20.34598904
137KDR0.34115910
138RAF10.33530530
139IRAK10.32682626
140STK240.30484420
141FYN0.29310070
142MAPKAPK20.28010323
143CDC70.27993915
144BRSK20.27008767
145RET0.26696159
146MAP3K110.25844105
147MAP2K60.25288297
148MAPK40.24751287

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030503.72455824
2Leishmaniasis_Homo sapiens_hsa051403.21336030
3Allograft rejection_Homo sapiens_hsa053302.82603773
4Graft-versus-host disease_Homo sapiens_hsa053322.79724418
5Protein export_Homo sapiens_hsa030602.73738491
6NF-kappa B signaling pathway_Homo sapiens_hsa040642.62581634
7* Toll-like receptor signaling pathway_Homo sapiens_hsa046202.54984143
8* Measles_Homo sapiens_hsa051622.50999182
9Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.37068796
10Staphylococcus aureus infection_Homo sapiens_hsa051502.34380148
11NOD-like receptor signaling pathway_Homo sapiens_hsa046212.33413517
12Legionellosis_Homo sapiens_hsa051342.32461107
13Primary immunodeficiency_Homo sapiens_hsa053402.31407368
14Osteoclast differentiation_Homo sapiens_hsa043802.30935015
15* RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.27875188
16Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.11192492
17Intestinal immune network for IgA production_Homo sapiens_hsa046722.06158465
18Pertussis_Homo sapiens_hsa051332.05263112
19* Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.03748971
20Type I diabetes mellitus_Homo sapiens_hsa049402.00836558
21Tuberculosis_Homo sapiens_hsa051522.00313154
22B cell receptor signaling pathway_Homo sapiens_hsa046621.99732096
23Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.93931145
24* Influenza A_Homo sapiens_hsa051641.92705566
25Hematopoietic cell lineage_Homo sapiens_hsa046401.83467399
26Antigen processing and presentation_Homo sapiens_hsa046121.81885751
27TNF signaling pathway_Homo sapiens_hsa046681.68674977
28Toxoplasmosis_Homo sapiens_hsa051451.62469211
29Malaria_Homo sapiens_hsa051441.62222142
30Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.60829129
31Caffeine metabolism_Homo sapiens_hsa002321.60141982
32* Herpes simplex infection_Homo sapiens_hsa051681.55920376
33Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.55212637
34Rheumatoid arthritis_Homo sapiens_hsa053231.55203167
35African trypanosomiasis_Homo sapiens_hsa051431.54326069
36Basal transcription factors_Homo sapiens_hsa030221.50256596
37RNA transport_Homo sapiens_hsa030131.44894067
38RNA degradation_Homo sapiens_hsa030181.44821948
39Mismatch repair_Homo sapiens_hsa034301.44438465
40Asthma_Homo sapiens_hsa053101.43768210
41Jak-STAT signaling pathway_Homo sapiens_hsa046301.43226199
42Shigellosis_Homo sapiens_hsa051311.37583787
43Salmonella infection_Homo sapiens_hsa051321.36234919
44Apoptosis_Homo sapiens_hsa042101.34574665
45Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.31605016
46Lysosome_Homo sapiens_hsa041421.29925805
47T cell receptor signaling pathway_Homo sapiens_hsa046601.29893600
48Sulfur metabolism_Homo sapiens_hsa009201.29845878
49Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.28825457
50Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.28201223
51* Hepatitis B_Homo sapiens_hsa051611.27666604
52Chemokine signaling pathway_Homo sapiens_hsa040621.26011633
53Homologous recombination_Homo sapiens_hsa034401.23073419
54Phagosome_Homo sapiens_hsa041451.22344816
55Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.19798607
56Selenocompound metabolism_Homo sapiens_hsa004501.18649316
57Cell cycle_Homo sapiens_hsa041101.17292759
58Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.15855277
59Nucleotide excision repair_Homo sapiens_hsa034201.15310248
60Autoimmune thyroid disease_Homo sapiens_hsa053201.07810955
61* Hepatitis C_Homo sapiens_hsa051601.06657984
62Fanconi anemia pathway_Homo sapiens_hsa034601.04696255
63Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.03334128
64Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.01999116
65Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.99784976
66Viral myocarditis_Homo sapiens_hsa054160.99445123
67Propanoate metabolism_Homo sapiens_hsa006400.99041679
68Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.95679311
69Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.93337181
70RNA polymerase_Homo sapiens_hsa030200.91308657
71Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.90934121
72Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.90227843
73Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.86207182
74Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.86113026
75Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.85057776
76Acute myeloid leukemia_Homo sapiens_hsa052210.84068053
77Sphingolipid metabolism_Homo sapiens_hsa006000.83761078
78AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.83398345
79Platelet activation_Homo sapiens_hsa046110.80025931
80Glycosaminoglycan degradation_Homo sapiens_hsa005310.79232177
81Leukocyte transendothelial migration_Homo sapiens_hsa046700.77441908
82Other glycan degradation_Homo sapiens_hsa005110.76700869
83Neurotrophin signaling pathway_Homo sapiens_hsa047220.75371049
84Prolactin signaling pathway_Homo sapiens_hsa049170.74878345
85Chronic myeloid leukemia_Homo sapiens_hsa052200.72394498
86Spliceosome_Homo sapiens_hsa030400.71830964
87Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.71711850
88Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.71524458
89Complement and coagulation cascades_Homo sapiens_hsa046100.70843751
90Pancreatic cancer_Homo sapiens_hsa052120.69841396
91Fatty acid elongation_Homo sapiens_hsa000620.65510952
92Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.63129616
93Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.61672372
94* Epstein-Barr virus infection_Homo sapiens_hsa051690.61135624
95Transcriptional misregulation in cancer_Homo sapiens_hsa052020.60695405
96Pyrimidine metabolism_Homo sapiens_hsa002400.59998089
97Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.59747235
98Systemic lupus erythematosus_Homo sapiens_hsa053220.58499839
99Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.58303319
100Amoebiasis_Homo sapiens_hsa051460.57797907
101Viral carcinogenesis_Homo sapiens_hsa052030.55052959
102Glutathione metabolism_Homo sapiens_hsa004800.54527659
103Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.53606257
104Steroid biosynthesis_Homo sapiens_hsa001000.52377691
105Regulation of autophagy_Homo sapiens_hsa041400.50660032
106HIF-1 signaling pathway_Homo sapiens_hsa040660.50435416
107Small cell lung cancer_Homo sapiens_hsa052220.48169520
108mRNA surveillance pathway_Homo sapiens_hsa030150.45775102
109Cysteine and methionine metabolism_Homo sapiens_hsa002700.45155479
110Collecting duct acid secretion_Homo sapiens_hsa049660.44660700
111Oocyte meiosis_Homo sapiens_hsa041140.43735486
112Peroxisome_Homo sapiens_hsa041460.43197768
113Folate biosynthesis_Homo sapiens_hsa007900.42971031
114Renin-angiotensin system_Homo sapiens_hsa046140.42237248
115Fatty acid biosynthesis_Homo sapiens_hsa000610.41850264
116Adipocytokine signaling pathway_Homo sapiens_hsa049200.41487934
117Galactose metabolism_Homo sapiens_hsa000520.39555626
118Circadian rhythm_Homo sapiens_hsa047100.38487552
119Carbohydrate digestion and absorption_Homo sapiens_hsa049730.36926459
120VEGF signaling pathway_Homo sapiens_hsa043700.36199278
121Non-small cell lung cancer_Homo sapiens_hsa052230.33214393
122Type II diabetes mellitus_Homo sapiens_hsa049300.33105743
123SNARE interactions in vesicular transport_Homo sapiens_hsa041300.32433635
124Insulin resistance_Homo sapiens_hsa049310.32054324
125ABC transporters_Homo sapiens_hsa020100.31977834
126Base excision repair_Homo sapiens_hsa034100.31951690
127HTLV-I infection_Homo sapiens_hsa051660.31496906
128Phosphatidylinositol signaling system_Homo sapiens_hsa040700.31476346
129Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.30085799
130DNA replication_Homo sapiens_hsa030300.29772049
131FoxO signaling pathway_Homo sapiens_hsa040680.28912609
132Sphingolipid signaling pathway_Homo sapiens_hsa040710.26608273
133Primary bile acid biosynthesis_Homo sapiens_hsa001200.26164238
134Endocytosis_Homo sapiens_hsa041440.24923850
135p53 signaling pathway_Homo sapiens_hsa041150.23149622
136Non-homologous end-joining_Homo sapiens_hsa034500.22470955
137Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.20351270
138mTOR signaling pathway_Homo sapiens_hsa041500.18826828
139Pentose phosphate pathway_Homo sapiens_hsa000300.18470664
140Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.17931295
141Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.16970480
142One carbon pool by folate_Homo sapiens_hsa006700.16753308

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