TBCE

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Cofactor E is one of four proteins (cofactors A, D, E, and C) involved in the pathway leading to correctly folded beta-tubulin from folding intermediates. Cofactors A and D are believed to play a role in capturing and stabilizing beta-tubulin intermediates in a quasi-native confirmation. Cofactor E binds to the cofactor D/beta-tubulin complex; interaction with cofactor C then causes the release of beta-tubulin polypeptides that are committed to the native state. Two transcript variants encoding the same protein have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1presynaptic membrane assembly (GO:0097105)4.85424165
2ionotropic glutamate receptor signaling pathway (GO:0035235)4.76786018
3CENP-A containing nucleosome assembly (GO:0034080)4.75571483
4neuron cell-cell adhesion (GO:0007158)4.72613457
5chromatin remodeling at centromere (GO:0031055)4.68618534
6presynaptic membrane organization (GO:0097090)4.43722310
7mitotic metaphase plate congression (GO:0007080)4.29415271
8proteasome assembly (GO:0043248)4.25487364
9protein localization to kinetochore (GO:0034501)4.16749905
10mitotic sister chromatid segregation (GO:0000070)4.16264481
11nuclear pore complex assembly (GO:0051292)4.11964043
12IMP biosynthetic process (GO:0006188)4.09441750
13sister chromatid segregation (GO:0000819)4.02542752
14establishment of integrated proviral latency (GO:0075713)4.01295717
15DNA strand elongation involved in DNA replication (GO:0006271)4.00803249
16synaptic transmission, glutamatergic (GO:0035249)3.96697007
17glutamate receptor signaling pathway (GO:0007215)3.96519203
18histone exchange (GO:0043486)3.95622335
19vocalization behavior (GO:0071625)3.93338678
20regulation of short-term neuronal synaptic plasticity (GO:0048172)3.88162214
21DNA strand elongation (GO:0022616)3.86081660
22DNA replication-independent nucleosome organization (GO:0034724)3.85681220
23DNA replication-independent nucleosome assembly (GO:0006336)3.85681220
24DNA unwinding involved in DNA replication (GO:0006268)3.82392695
25DNA replication checkpoint (GO:0000076)3.82221261
26protein localization to chromosome, centromeric region (GO:0071459)3.80529067
27metaphase plate congression (GO:0051310)3.80025648
28negative regulation of synaptic transmission, GABAergic (GO:0032229)3.79959923
29IMP metabolic process (GO:0046040)3.75399557
30nuclear pore organization (GO:0006999)3.74891473
31ribosome assembly (GO:0042255)3.74420443
32regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.73982312
33regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.71890391
34neuron recognition (GO:0008038)3.68523595
35mitotic chromosome condensation (GO:0007076)3.66476078
36telomere maintenance via semi-conservative replication (GO:0032201)3.65018986
37kinetochore organization (GO:0051383)3.64329031
38folic acid-containing compound biosynthetic process (GO:0009396)3.61630956
39startle response (GO:0001964)3.57491126
40protein localization to synapse (GO:0035418)3.56387159
41regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.50789046
42neuron-neuron synaptic transmission (GO:0007270)3.48205543
43purine nucleobase biosynthetic process (GO:0009113)3.46745327
44DNA double-strand break processing (GO:0000729)3.43754919
45postsynaptic membrane organization (GO:0001941)3.42676275
46kinetochore assembly (GO:0051382)3.39818079
47nonmotile primary cilium assembly (GO:0035058)3.38273429
48DNA ligation (GO:0006266)3.37973009
49spindle checkpoint (GO:0031577)3.36122676
50positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.34061525
51negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.32612306
52regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.30868190
53negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.29772143
54anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.29361176
55histone H3-K4 trimethylation (GO:0080182)3.27867208
56mitotic spindle checkpoint (GO:0071174)3.27000409
57negative regulation of chromosome segregation (GO:0051985)3.24954187
58negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.24107305
59negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.24107305
60negative regulation of mitotic sister chromatid segregation (GO:0033048)3.24107305
61negative regulation of mitotic sister chromatid separation (GO:2000816)3.24107305
62negative regulation of sister chromatid segregation (GO:0033046)3.24107305
63L-serine metabolic process (GO:0006563)3.24063420
64mitotic nuclear envelope disassembly (GO:0007077)3.23869195
65cullin deneddylation (GO:0010388)3.22170627
66synaptic vesicle exocytosis (GO:0016079)3.21410451
67non-recombinational repair (GO:0000726)3.20151741
68double-strand break repair via nonhomologous end joining (GO:0006303)3.20151741
69nucleobase biosynthetic process (GO:0046112)3.19700314
70regulation of glutamate receptor signaling pathway (GO:1900449)3.17923521
71mitotic recombination (GO:0006312)3.17391490
72establishment of chromosome localization (GO:0051303)3.16180187
73chaperone-mediated protein transport (GO:0072321)3.13900281
74neuronal action potential propagation (GO:0019227)3.11953478
75positive regulation of cellular amide metabolic process (GO:0034250)3.10811969
76DNA replication initiation (GO:0006270)3.10584677
77positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.10511003
78transmission of nerve impulse (GO:0019226)3.09885415
79regulation of excitatory postsynaptic membrane potential (GO:0060079)3.09111799
80regulation of chromosome segregation (GO:0051983)3.09079539
81mitochondrial RNA metabolic process (GO:0000959)3.07443247
82mitotic spindle assembly checkpoint (GO:0007094)3.07270664
83negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.04816120
84negative regulation of ligase activity (GO:0051352)3.04816120
85telomere maintenance via recombination (GO:0000722)3.04184673
86mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.03769051
87spindle assembly checkpoint (GO:0071173)3.03209120
88regulation of glutamate secretion (GO:0014048)3.02452669
89pore complex assembly (GO:0046931)3.02234984
90neurotransmitter-gated ion channel clustering (GO:0072578)3.02142767
91regulation of mitochondrial translation (GO:0070129)3.01664586
92mitotic sister chromatid cohesion (GO:0007064)3.01309079
93establishment of viral latency (GO:0019043)3.00289086
94regulation of mitotic metaphase/anaphase transition (GO:0030071)2.99367480
95regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.99367480
96protein deneddylation (GO:0000338)2.99276719
97long-term synaptic potentiation (GO:0060291)2.99006120
98ribosome biogenesis (GO:0042254)2.98123591
99gamma-aminobutyric acid signaling pathway (GO:0007214)2.97883142
100regulation of mitotic spindle organization (GO:0060236)2.97400512
101nuclear envelope disassembly (GO:0051081)2.96857428
102membrane disassembly (GO:0030397)2.96857428
103regulation of spindle organization (GO:0090224)2.96007225
104chromosome segregation (GO:0007059)2.95004859
105transcription from mitochondrial promoter (GO:0006390)2.93633543
106cAMP catabolic process (GO:0006198)2.93485685
107pteridine-containing compound biosynthetic process (GO:0042559)2.92489342
108response to pheromone (GO:0019236)2.92466813
109positive regulation of protein homodimerization activity (GO:0090073)2.92208124
110DNA topological change (GO:0006265)2.91613248
111regulation of centriole replication (GO:0046599)2.90847041
112DNA damage response, detection of DNA damage (GO:0042769)2.90692677
113G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.90691286
114spliceosomal snRNP assembly (GO:0000387)2.90263304
115DNA catabolic process, exonucleolytic (GO:0000738)2.89773204
116cyclic nucleotide catabolic process (GO:0009214)2.89659175
117regulation of mitotic sister chromatid separation (GO:0010965)2.89441626
118regulation of mitotic sister chromatid segregation (GO:0033047)2.89441626
119regulation of sister chromatid segregation (GO:0033045)2.89441626
120membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.89374980
121protein complex localization (GO:0031503)2.88779634
122positive regulation of synapse assembly (GO:0051965)2.88478974
123regulation of long-term neuronal synaptic plasticity (GO:0048169)2.87342317
124regulation of postsynaptic membrane potential (GO:0060078)2.86755997
125negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.86519993
126negative regulation of translation, ncRNA-mediated (GO:0040033)2.86519993
127regulation of translation, ncRNA-mediated (GO:0045974)2.86519993
128tRNA aminoacylation for protein translation (GO:0006418)2.86105235
129nucleotide-excision repair, DNA gap filling (GO:0006297)2.85653540
130regulation of synaptic vesicle exocytosis (GO:2000300)2.85327171
131ATP-dependent chromatin remodeling (GO:0043044)2.84890736
132pseudouridine synthesis (GO:0001522)2.84641567
133regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.84420360
134positive regulation of dendritic spine morphogenesis (GO:0061003)2.83437412
135amino acid activation (GO:0043038)2.81684329
136tRNA aminoacylation (GO:0043039)2.81684329
137regulation of chemokine-mediated signaling pathway (GO:0070099)2.81026525
138DNA replication-dependent nucleosome assembly (GO:0006335)2.80354559
139DNA replication-dependent nucleosome organization (GO:0034723)2.80354559
140positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.80261539
141regulation of respiratory system process (GO:0044065)2.80238271
142maturation of 5.8S rRNA (GO:0000460)2.78985038
143righting reflex (GO:0060013)2.77890508
144positive regulation of chromosome segregation (GO:0051984)2.76232768
145maturation of SSU-rRNA (GO:0030490)2.75696726
146axonal fasciculation (GO:0007413)2.75439484
147tetrahydrofolate metabolic process (GO:0046653)2.75015774
148chromatin assembly or disassembly (GO:0006333)2.74296785
149formation of translation preinitiation complex (GO:0001731)2.74107757
150dendrite development (GO:0016358)2.73523103
151positive regulation of membrane potential (GO:0045838)2.73300806
152regulation of synaptic vesicle transport (GO:1902803)2.72863501
153regulation of synaptic transmission, glutamatergic (GO:0051966)2.72789028
154detection of calcium ion (GO:0005513)2.71404297
155regulation of neuronal synaptic plasticity (GO:0048168)2.70235289
156membrane depolarization (GO:0051899)2.70211130
157negative regulation of neurotransmitter transport (GO:0051589)2.70207517
158cerebellar Purkinje cell differentiation (GO:0021702)2.70090106
159locomotory exploration behavior (GO:0035641)2.68463441
160regulation of timing of cell differentiation (GO:0048505)2.66144864
161regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.65150445
162regulation of synapse assembly (GO:0051963)2.64205960
163positive regulation of amino acid transport (GO:0051957)2.63591713
164regulation of respiratory gaseous exchange (GO:0043576)2.59708533
165regulation of amino acid transport (GO:0051955)2.58177978
166neuronal action potential (GO:0019228)2.57625034
167regulation of neurotransmitter secretion (GO:0046928)2.56795756
168cerebellar granule cell differentiation (GO:0021707)2.56726054
169transferrin transport (GO:0033572)2.52707716
170vesicle docking involved in exocytosis (GO:0006904)2.52643313
171protein localization to cilium (GO:0061512)2.52411833
172regulation of beta-amyloid formation (GO:1902003)2.51891576
173long-chain fatty acid biosynthetic process (GO:0042759)2.51142506
174mechanosensory behavior (GO:0007638)2.50221045
175response to redox state (GO:0051775)2.49529061
176regulation of catecholamine metabolic process (GO:0042069)2.48776157
177regulation of dopamine metabolic process (GO:0042053)2.48776157
178glutamate secretion (GO:0014047)2.48772016
179developmental pigmentation (GO:0048066)2.48031354
180regulation of inositol phosphate biosynthetic process (GO:0010919)2.47505161
181behavioral response to ethanol (GO:0048149)2.47190771
182synaptic vesicle endocytosis (GO:0048488)2.46156545
183calcium ion-dependent exocytosis (GO:0017156)2.46074729
184cAMP-mediated signaling (GO:0019933)2.45635969
185negative regulation of dendrite morphogenesis (GO:0050774)2.45398641
186adult walking behavior (GO:0007628)2.44551013
187membrane depolarization during action potential (GO:0086010)2.44306674
188membrane hyperpolarization (GO:0060081)2.44042832
189cerebral cortex radially oriented cell migration (GO:0021799)2.43831097
190positive regulation of dendritic spine development (GO:0060999)2.43415494
191* adult behavior (GO:0030534)2.42409896
192learning (GO:0007612)2.42268372
193positive regulation of action potential (GO:0045760)2.41930427
194neurotransmitter secretion (GO:0007269)2.41321235
195vesicle docking (GO:0048278)2.38568377
196regulation of vesicle fusion (GO:0031338)2.38426368
197striatum development (GO:0021756)2.38210153
198negative regulation of exocytosis (GO:0045920)2.38196044
199neurotransmitter uptake (GO:0001504)2.37030746

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.66861774
2EZH2_22144423_ChIP-Seq_EOC_Human5.18750516
3GBX2_23144817_ChIP-Seq_PC3_Human4.83055787
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.75857090
5MYC_18555785_ChIP-Seq_MESCs_Mouse3.97962194
6E2F4_17652178_ChIP-ChIP_JURKAT_Human3.91423825
7FOXM1_23109430_ChIP-Seq_U2OS_Human3.86289377
8* GABP_17652178_ChIP-ChIP_JURKAT_Human3.42168927
9FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.32562340
10EST1_17652178_ChIP-ChIP_JURKAT_Human3.30765155
11CREB1_15753290_ChIP-ChIP_HEK293T_Human3.24079696
12E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.23167762
13EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.01261282
14JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.00307841
15HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.96107979
16AR_21909140_ChIP-Seq_LNCAP_Human2.89253301
17ETS1_20019798_ChIP-Seq_JURKAT_Human2.86475813
18ZFP57_27257070_Chip-Seq_ESCs_Mouse2.78717852
19MYC_19030024_ChIP-ChIP_MESCs_Mouse2.74323713
20* CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.73625374
21TAF15_26573619_Chip-Seq_HEK293_Human2.64247076
22MYC_18358816_ChIP-ChIP_MESCs_Mouse2.63344209
23GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.60934320
24MYC_19079543_ChIP-ChIP_MESCs_Mouse2.48802042
25POU3F2_20337985_ChIP-ChIP_501MEL_Human2.47883593
26* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.35924008
27THAP11_20581084_ChIP-Seq_MESCs_Mouse2.34490588
28NELFA_20434984_ChIP-Seq_ESCs_Mouse2.30962921
29TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.30892981
30* ELK1_19687146_ChIP-ChIP_HELA_Human2.29202333
31PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.27843186
32MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.22848442
33SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.21925376
34NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.21157291
35HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.19638660
36YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.14892276
37E2F1_21310950_ChIP-Seq_MCF-7_Human2.12805631
38GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.12569495
39DCP1A_22483619_ChIP-Seq_HELA_Human2.12249990
40P300_19829295_ChIP-Seq_ESCs_Human2.09469336
41E2F1_18555785_ChIP-Seq_MESCs_Mouse2.07934504
42MYCN_18555785_ChIP-Seq_MESCs_Mouse2.07355627
43* XRN2_22483619_ChIP-Seq_HELA_Human2.06943090
44SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.05995750
45JARID2_20064375_ChIP-Seq_MESCs_Mouse2.05791988
46CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.02307210
47FUS_26573619_Chip-Seq_HEK293_Human2.00158218
48TTF2_22483619_ChIP-Seq_HELA_Human1.98958263
49SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.98437624
50CTBP2_25329375_ChIP-Seq_LNCAP_Human1.97317355
51FOXP3_21729870_ChIP-Seq_TREG_Human1.95964287
52VDR_23849224_ChIP-Seq_CD4+_Human1.94437724
53* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.94389430
54SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.92048326
55MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.91905945
56* GABP_19822575_ChIP-Seq_HepG2_Human1.91187644
57FLI1_27457419_Chip-Seq_LIVER_Mouse1.89283615
58BMI1_23680149_ChIP-Seq_NPCS_Mouse1.86625154
59BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.86563346
60PCGF2_27294783_Chip-Seq_ESCs_Mouse1.85796592
61REST_21632747_ChIP-Seq_MESCs_Mouse1.83689659
62SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.82718803
63EED_16625203_ChIP-ChIP_MESCs_Mouse1.82066155
64PADI4_21655091_ChIP-ChIP_MCF-7_Human1.80377805
65ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.77223429
66EZH2_27304074_Chip-Seq_ESCs_Mouse1.76580205
67SMAD4_21799915_ChIP-Seq_A2780_Human1.75295502
68PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.74132596
69CTBP1_25329375_ChIP-Seq_LNCAP_Human1.72979298
70MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.72597637
71POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.71115088
72ZFX_18555785_ChIP-Seq_MESCs_Mouse1.69901988
73AR_21572438_ChIP-Seq_LNCaP_Human1.69571781
74* SRF_21415370_ChIP-Seq_HL-1_Mouse1.69482546
75SALL1_21062744_ChIP-ChIP_HESCs_Human1.69037508
76HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.68460689
77JARID2_20075857_ChIP-Seq_MESCs_Mouse1.66172424
78IGF1R_20145208_ChIP-Seq_DFB_Human1.64179848
79NANOG_18555785_Chip-Seq_ESCs_Mouse1.63130930
80SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.62425829
81CBX2_27304074_Chip-Seq_ESCs_Mouse1.61476687
82ER_23166858_ChIP-Seq_MCF-7_Human1.61247655
83TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.61120817
84EZH2_18974828_ChIP-Seq_MESCs_Mouse1.59532069
85RNF2_18974828_ChIP-Seq_MESCs_Mouse1.59532069
86SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.59380377
87CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.58480169
88OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.58043566
89NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.57635727
90EWS_26573619_Chip-Seq_HEK293_Human1.57480117
91EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.57216244
92PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.56904737
93ELF1_17652178_ChIP-ChIP_JURKAT_Human1.55036156
94* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.53740312
95PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.53342182
96PIAS1_25552417_ChIP-Seq_VCAP_Human1.53104588
97P53_22387025_ChIP-Seq_ESCs_Mouse1.52466444
98E2F1_18555785_Chip-Seq_ESCs_Mouse1.51518585
99RNF2_27304074_Chip-Seq_NSC_Mouse1.51449593
100DROSHA_22980978_ChIP-Seq_HELA_Human1.50441457
101SUZ12_27294783_Chip-Seq_NPCs_Mouse1.49747292
102TOP2B_26459242_ChIP-Seq_MCF-7_Human1.47219336
103SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.46944589
104EZH2_27294783_Chip-Seq_ESCs_Mouse1.46019219
105SUZ12_18555785_Chip-Seq_ESCs_Mouse1.43992634
106MTF2_20144788_ChIP-Seq_MESCs_Mouse1.42956784
107STAT3_18555785_Chip-Seq_ESCs_Mouse1.41824911
108EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.41189912
109SMAD3_21741376_ChIP-Seq_EPCs_Human1.40872481
110STAT3_23295773_ChIP-Seq_U87_Human1.40713565
111CMYC_18555785_Chip-Seq_ESCs_Mouse1.39835856
112KDM5A_27292631_Chip-Seq_BREAST_Human1.38405336
113NFE2_27457419_Chip-Seq_LIVER_Mouse1.37471640
114EZH2_27294783_Chip-Seq_NPCs_Mouse1.34166242
115TCF4_23295773_ChIP-Seq_U87_Human1.33687151
116SUZ12_27294783_Chip-Seq_ESCs_Mouse1.33648226
117PCGF2_27294783_Chip-Seq_NPCs_Mouse1.32526040
118YY1_21170310_ChIP-Seq_MESCs_Mouse1.32271430
119E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.31660897
120P300_18555785_Chip-Seq_ESCs_Mouse1.30760634
121AR_25329375_ChIP-Seq_VCAP_Human1.30690057
122SMAD_19615063_ChIP-ChIP_OVARY_Human1.29602811
123PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.29535467
124* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.29510254
125MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.29415069
126IRF1_19129219_ChIP-ChIP_H3396_Human1.29372042
127POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.28697338
128FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.28678681
129RBPJ_22232070_ChIP-Seq_NCS_Mouse1.28509944
130VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.28506268
131ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.28156083
132UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.27775546
133RUNX1_27457419_Chip-Seq_LIVER_Mouse1.27607408
134* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.27278051
135SOX2_18555785_Chip-Seq_ESCs_Mouse1.26057047
136RNF2_27304074_Chip-Seq_ESCs_Mouse1.25410381
137CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.25312095
138NMYC_18555785_Chip-Seq_ESCs_Mouse1.25304153
139VDR_22108803_ChIP-Seq_LS180_Human1.22808257
140REST_18959480_ChIP-ChIP_MESCs_Mouse1.22401409
141NANOG_18555785_ChIP-Seq_MESCs_Mouse1.22349717
142MYC_18940864_ChIP-ChIP_HL60_Human1.22111882
143RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.22081537
144CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.21286214
145CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.21001087
146* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.20654630
147RUNX2_22187159_ChIP-Seq_PCA_Human1.20405379
148SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.19295525
149TAL1_26923725_Chip-Seq_HPCs_Mouse1.17942431
150KDM2B_26808549_Chip-Seq_REH_Human1.15292800
151JUN_21703547_ChIP-Seq_K562_Human1.14456123
152TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.14420456
153ZNF274_21170338_ChIP-Seq_K562_Hela1.11578656
154PU1_27457419_Chip-Seq_LIVER_Mouse1.11542152
155OCT4_18555785_Chip-Seq_ESCs_Mouse1.10288721
156* SOX17_20123909_ChIP-Seq_XEN_Mouse1.09894545
157HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.08096913
158NANOG_16153702_ChIP-ChIP_HESCs_Human1.07461348
159KLF4_18555785_Chip-Seq_ESCs_Mouse1.07396841
160CTCF_18555785_Chip-Seq_ESCs_Mouse1.06738299
161SMAD1_18555785_Chip-Seq_ESCs_Mouse1.05894031
162* SOX2_21211035_ChIP-Seq_LN229_Gbm1.05127217
163PRDM14_20953172_ChIP-Seq_ESCs_Human1.03548722
164ZFX_18555785_Chip-Seq_ESCs_Mouse1.01269972
165SOX2_16153702_ChIP-ChIP_HESCs_Human1.01002688
166POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.00276374
167BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.97114257
168CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.96514774
169DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.95624917
170SOX2_18555785_ChIP-Seq_MESCs_Mouse0.94809657
171KLF4_18555785_ChIP-Seq_MESCs_Mouse0.94097895
172ERG_20887958_ChIP-Seq_HPC-7_Mouse0.91202380
173POU5F1_16153702_ChIP-ChIP_HESCs_Human0.90779742
174CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.90518810
175* TFEB_21752829_ChIP-Seq_HELA_Human0.89822598
176CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.85210412
177SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.83861648
178TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.83501608
179TP63_19390658_ChIP-ChIP_HaCaT_Human0.82471592
180ESR1_15608294_ChIP-ChIP_MCF-7_Human0.81629557
181SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.80214272
182DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.79838200
183ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.79398174
184KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.77180168
185TBX5_21415370_ChIP-Seq_HL-1_Mouse0.77174759
186CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.75485355
187NANOG_21062744_ChIP-ChIP_HESCs_Human0.74560669
188* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.74082366
189* ELK1_22589737_ChIP-Seq_MCF10A_Human0.73478142
190HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.71725259
191NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.71328753
192CHD1_26751641_Chip-Seq_LNCaP_Human0.70420640
193TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.67378492
194* SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.66579174
195SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.66375389
196CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.65780155

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern4.99871342
2MP0010094_abnormal_chromosome_stability4.19986607
3MP0003693_abnormal_embryo_hatching4.19724259
4MP0003111_abnormal_nucleus_morphology3.69804253
5MP0004957_abnormal_blastocyst_morpholog3.63367251
6MP0004859_abnormal_synaptic_plasticity3.25697699
7MP0008932_abnormal_embryonic_tissue3.15812067
8MP0003077_abnormal_cell_cycle3.06301152
9MP0005646_abnormal_pituitary_gland2.80909189
10MP0003635_abnormal_synaptic_transmissio2.75017991
11MP0002735_abnormal_chemical_nociception2.73418280
12MP0005645_abnormal_hypothalamus_physiol2.66656549
13MP0009046_muscle_twitch2.65063351
14MP0009745_abnormal_behavioral_response2.64046292
15MP0001188_hyperpigmentation2.58262075
16MP0005423_abnormal_somatic_nervous2.50760427
17MP0002272_abnormal_nervous_system2.39238488
18MP0002063_abnormal_learning/memory/cond2.33563460
19MP0002064_seizures2.32775899
20MP0004270_analgesia2.32726368
21MP0006276_abnormal_autonomic_nervous2.30870317
22MP0002572_abnormal_emotion/affect_behav2.26906162
23MP0001968_abnormal_touch/_nociception2.25639928
24MP0008007_abnormal_cellular_replicative2.25171739
25MP0001501_abnormal_sleep_pattern2.21635291
26MP0001486_abnormal_startle_reflex2.17790267
27MP0001529_abnormal_vocalization2.15192156
28MP0002734_abnormal_mechanical_nocicepti2.10898921
29MP0001986_abnormal_taste_sensitivity2.08141066
30MP0001440_abnormal_grooming_behavior2.07115826
31MP0003718_maternal_effect2.03428050
32MP0002736_abnormal_nociception_after2.02146531
33MP0002638_abnormal_pupillary_reflex2.01230763
34MP0006292_abnormal_olfactory_placode1.98198782
35MP0010386_abnormal_urinary_bladder1.98074391
36MP0005409_darkened_coat_color1.97947735
37MP0003806_abnormal_nucleotide_metabolis1.97436234
38MP0003941_abnormal_skin_development1.93887305
39MP0003787_abnormal_imprinting1.93738470
40MP0000778_abnormal_nervous_system1.91530036
41MP0001730_embryonic_growth_arrest1.90635481
42MP0002876_abnormal_thyroid_physiology1.81924921
43MP0002067_abnormal_sensory_capabilities1.78754439
44MP0002822_catalepsy1.71723081
45MP0001293_anophthalmia1.67718130
46MP0003786_premature_aging1.66536770
47MP0003890_abnormal_embryonic-extraembry1.65594391
48MP0001905_abnormal_dopamine_level1.62337324
49MP0003183_abnormal_peptide_metabolism1.60456817
50MP0003186_abnormal_redox_activity1.59351751
51MP0000015_abnormal_ear_pigmentation1.58170103
52MP0001502_abnormal_circadian_rhythm1.56498559
53MP0002557_abnormal_social/conspecific_i1.54850060
54MP0001970_abnormal_pain_threshold1.54659420
55MP0001697_abnormal_embryo_size1.54449192
56MP0000350_abnormal_cell_proliferation1.53745185
57MP0005380_embryogenesis_phenotype1.53022835
58MP0001672_abnormal_embryogenesis/_devel1.53022835
59MP0004142_abnormal_muscle_tone1.51276278
60MP0008569_lethality_at_weaning1.49665756
61MP0006035_abnormal_mitochondrial_morpho1.48042071
62MP0004147_increased_porphyrin_level1.47908034
63MP0006036_abnormal_mitochondrial_physio1.47309854
64MP0001984_abnormal_olfaction1.46232021
65MP0005171_absent_coat_pigmentation1.46108861
66MP0003937_abnormal_limbs/digits/tail_de1.45991786
67MP0003122_maternal_imprinting1.45635347
68MP0004742_abnormal_vestibular_system1.42341157
69MP0002184_abnormal_innervation1.41637522
70MP0002733_abnormal_thermal_nociception1.41022525
71MP0000569_abnormal_digit_pigmentation1.37653628
72MP0004924_abnormal_behavior1.37618956
73MP0005386_behavior/neurological_phenoty1.37618956
74MP0009697_abnormal_copulation1.37158452
75MP0000372_irregular_coat_pigmentation1.35665205
76MP0010030_abnormal_orbit_morphology1.34759620
77MP0002085_abnormal_embryonic_tissue1.34654913
78MP0003984_embryonic_growth_retardation1.32540671
79MP0002080_prenatal_lethality1.30850850
80MP0002102_abnormal_ear_morphology1.30358938
81MP0002084_abnormal_developmental_patter1.28973524
82MP0002088_abnormal_embryonic_growth/wei1.26989646
83MP0005499_abnormal_olfactory_system1.24142380
84MP0005394_taste/olfaction_phenotype1.24142380
85MP0005408_hypopigmentation1.23782573
86MP0000749_muscle_degeneration1.21979405
87MP0002160_abnormal_reproductive_system1.18602382
88MP0003567_abnormal_fetal_cardiomyocyte1.18146992
89MP0008995_early_reproductive_senescence1.16295606
90MP0004233_abnormal_muscle_weight1.16138602
91MP0003123_paternal_imprinting1.15670711
92MP0002233_abnormal_nose_morphology1.15217539
93MP0009780_abnormal_chondrocyte_physiolo1.14892231
94MP0008789_abnormal_olfactory_epithelium1.14703115
95MP0003315_abnormal_perineum_morphology1.13896949
96MP0002210_abnormal_sex_determination1.13013042
97* MP0002882_abnormal_neuron_morphology1.12661829
98MP0001661_extended_life_span1.12280387
99MP0005551_abnormal_eye_electrophysiolog1.11378256
100MP0002697_abnormal_eye_size1.11076122
101MP0009672_abnormal_birth_weight1.10377290
102MP0004811_abnormal_neuron_physiology1.10058418
103MP0001286_abnormal_eye_development1.09897870
104MP0000358_abnormal_cell_content/1.09331643
105* MP0000955_abnormal_spinal_cord1.08451033
106MP0005379_endocrine/exocrine_gland_phen1.07272389
107MP0005187_abnormal_penis_morphology1.05738157
108MP0010352_gastrointestinal_tract_polyps1.03768543
109MP0001963_abnormal_hearing_physiology1.03592466
110MP0005174_abnormal_tail_pigmentation1.02376984
111MP0001929_abnormal_gametogenesis1.02027705
112MP0000313_abnormal_cell_death1.01133415
113* MP0002066_abnormal_motor_capabilities/c1.01039795
114MP0000537_abnormal_urethra_morphology0.97937703
115MP0003755_abnormal_palate_morphology0.96168698
116MP0000920_abnormal_myelination0.95931203
117MP0001145_abnormal_male_reproductive0.95474699
118MP0002837_dystrophic_cardiac_calcinosis0.95155236
119MP0000647_abnormal_sebaceous_gland0.93620269
120MP0003136_yellow_coat_color0.92207817
121MP0003221_abnormal_cardiomyocyte_apopto0.91395042
122MP0000653_abnormal_sex_gland0.91021532
123MP0003879_abnormal_hair_cell0.90315254
124MP0002234_abnormal_pharynx_morphology0.90091784
125MP0002277_abnormal_respiratory_mucosa0.89430825
126MP0000681_abnormal_thyroid_gland0.88934408
127* MP0002229_neurodegeneration0.88304871
128MP0002095_abnormal_skin_pigmentation0.88130850
129MP0004197_abnormal_fetal_growth/weight/0.87211530
130MP0000631_abnormal_neuroendocrine_gland0.87115826
131MP0003385_abnormal_body_wall0.87066190
132MP0002111_abnormal_tail_morphology0.85784378
133MP0000026_abnormal_inner_ear0.85465233
134MP0001299_abnormal_eye_distance/0.84512543
135MP0009703_decreased_birth_body0.84386070
136MP0002086_abnormal_extraembryonic_tissu0.83403632
137MP0005671_abnormal_response_to0.83204114
138MP0002090_abnormal_vision0.82760873
139MP0002092_abnormal_eye_morphology0.82556029
140MP0008058_abnormal_DNA_repair0.82066626
141MP0002069_abnormal_eating/drinking_beha0.80629051
142MP0005075_abnormal_melanosome_morpholog0.80366354
143MP0003633_abnormal_nervous_system0.80170999
144MP0009250_abnormal_appendicular_skeleto0.80094304
145MP0000049_abnormal_middle_ear0.79583948
146MP0003631_nervous_system_phenotype0.78656982
147MP0008260_abnormal_autophagy0.78274611
148MP0001324_abnormal_eye_pigmentation0.77146253
149MP0000566_synostosis0.76314184
150* MP0002752_abnormal_somatic_nervous0.75768089
151MP0010307_abnormal_tumor_latency0.75368493
152MP0001764_abnormal_homeostasis0.74747336
153MP0002152_abnormal_brain_morphology0.74557445
154MP0002282_abnormal_trachea_morphology0.73607316
155MP0001727_abnormal_embryo_implantation0.71942861
156MP0005535_abnormal_body_temperature0.71649033
157MP0003935_abnormal_craniofacial_develop0.71431410
158MP0001485_abnormal_pinna_reflex0.70290218
159MP0003698_abnormal_male_reproductive0.70244560
160MP0003861_abnormal_nervous_system0.69901510
161MP0001664_abnormal_digestion0.69529111
162MP0005330_cardiomyopathy0.68992466
163MP0003942_abnormal_urinary_system0.68401430
164MP0004084_abnormal_cardiac_muscle0.68304942
165MP0008877_abnormal_DNA_methylation0.68145021
166MP0002163_abnormal_gland_morphology0.68111681
167MP0002938_white_spotting0.67675121
168MP0006072_abnormal_retinal_apoptosis0.67325228
169MP0001835_abnormal_antigen_presentation0.67035084
170MP0002009_preneoplasia0.66850007
171MP0000751_myopathy0.66204456
172MP0003119_abnormal_digestive_system0.65651884
173MP0001177_atelectasis0.65217804
174MP0005310_abnormal_salivary_gland0.63467311
175MP0003121_genomic_imprinting0.63330782
176MP0002177_abnormal_outer_ear0.63175260
177MP0005391_vision/eye_phenotype0.62944156
178MP0004885_abnormal_endolymph0.62149828
179MP0001119_abnormal_female_reproductive0.61842336
180MP0008872_abnormal_physiological_respon0.61721848
181MP0003632_abnormal_nervous_system0.59664994
182MP0008057_abnormal_DNA_replication0.57313298

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)4.82955602
2Febrile seizures (HP:0002373)3.98133343
3Hypothermia (HP:0002045)3.93960172
4Abnormal hair whorl (HP:0010721)3.85872794
5Increased serum pyruvate (HP:0003542)3.72270191
6Chromsome breakage (HP:0040012)3.69614789
7Abnormality of glycolysis (HP:0004366)3.56989725
8Epileptic encephalopathy (HP:0200134)3.35991658
9Focal seizures (HP:0007359)3.17307128
10Acute encephalopathy (HP:0006846)3.16597129
11Medial flaring of the eyebrow (HP:0010747)3.12411715
12Progressive cerebellar ataxia (HP:0002073)3.09855282
13Meckel diverticulum (HP:0002245)3.02386933
14Abnormality of the labia minora (HP:0012880)3.01272814
15Aplasia/Hypoplasia of the uvula (HP:0010293)3.01212312
16Hyperventilation (HP:0002883)2.99728976
17Abnormality of chromosome stability (HP:0003220)2.98590294
18Abnormal mitochondria in muscle tissue (HP:0008316)2.93406924
19Retinal dysplasia (HP:0007973)2.92828670
20Absent/shortened dynein arms (HP:0200106)2.91657772
21Dynein arm defect of respiratory motile cilia (HP:0012255)2.91657772
22Chronic hepatic failure (HP:0100626)2.86269186
23Abnormality of the ileum (HP:0001549)2.82029078
24Abnormality of the preputium (HP:0100587)2.80719101
25Gait imbalance (HP:0002141)2.79430850
26Nephrogenic diabetes insipidus (HP:0009806)2.77158419
27Atonic seizures (HP:0010819)2.74066991
28Increased CSF lactate (HP:0002490)2.68119117
29Broad-based gait (HP:0002136)2.68105994
30Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.64801215
31Abnormality of alanine metabolism (HP:0010916)2.64801215
32Hyperalaninemia (HP:0003348)2.64801215
33Aplasia/Hypoplasia of the sacrum (HP:0008517)2.64309105
34Cerebral edema (HP:0002181)2.64172837
35Abnormality of methionine metabolism (HP:0010901)2.61961733
36Congenital primary aphakia (HP:0007707)2.60337942
37Multiple enchondromatosis (HP:0005701)2.59129961
38Split foot (HP:0001839)2.57899213
39Pancreatic fibrosis (HP:0100732)2.56029256
40Abnormal lung lobation (HP:0002101)2.55589559
41Gaze-evoked nystagmus (HP:0000640)2.54096187
42Abnormal umbilical cord blood vessels (HP:0011403)2.53800092
43Single umbilical artery (HP:0001195)2.53800092
44Abnormality of the fetal cardiovascular system (HP:0010948)2.53800092
45Absent speech (HP:0001344)2.51156682
46Myokymia (HP:0002411)2.51046734
47Patchy hypopigmentation of hair (HP:0011365)2.48239098
48Progressive macrocephaly (HP:0004481)2.47722076
49Protruding tongue (HP:0010808)2.47625647
50Blue irides (HP:0000635)2.47549222
51Increased hepatocellular lipid droplets (HP:0006565)2.45750725
52Duodenal stenosis (HP:0100867)2.45325542
53Small intestinal stenosis (HP:0012848)2.45325542
54Abnormal ciliary motility (HP:0012262)2.44022753
55Mitochondrial inheritance (HP:0001427)2.43733458
56Cortical dysplasia (HP:0002539)2.42860551
57Increased serum lactate (HP:0002151)2.42532693
58True hermaphroditism (HP:0010459)2.41891535
59Abnormality of midbrain morphology (HP:0002418)2.40180514
60Molar tooth sign on MRI (HP:0002419)2.40180514
61Abnormality of DNA repair (HP:0003254)2.38468605
62Type II lissencephaly (HP:0007260)2.36881432
63Abnormal respiratory epithelium morphology (HP:0012253)2.31544121
64Abnormal respiratory motile cilium morphology (HP:0005938)2.31544121
65Reticulocytopenia (HP:0001896)2.30332241
66Abnormality of serum amino acid levels (HP:0003112)2.29988089
67Aplasia/Hypoplasia of the lens (HP:0008063)2.28088429
68Degeneration of anterior horn cells (HP:0002398)2.26107297
69Abnormality of the anterior horn cell (HP:0006802)2.26107297
70Optic nerve hypoplasia (HP:0000609)2.24018823
71Reduced antithrombin III activity (HP:0001976)2.23302144
72Genital tract atresia (HP:0001827)2.21428187
73* Birth length less than 3rd percentile (HP:0003561)2.21381884
74Esotropia (HP:0000565)2.20850866
75Hyperglycinemia (HP:0002154)2.19253994
76Increased nuchal translucency (HP:0010880)2.18388462
77Fair hair (HP:0002286)2.17443406
78Renal Fanconi syndrome (HP:0001994)2.17159962
79Dialeptic seizures (HP:0011146)2.17049869
80Nephroblastoma (Wilms tumor) (HP:0002667)2.16876463
81Exercise intolerance (HP:0003546)2.16547717
82Osteomalacia (HP:0002749)2.16250682
83Lipid accumulation in hepatocytes (HP:0006561)2.15905573
84Scanning speech (HP:0002168)2.15790344
85Hypoplastic pelvis (HP:0008839)2.14308910
86Abnormality of the duodenum (HP:0002246)2.12141290
87Lactic acidosis (HP:0003128)2.11635026
88Hepatocellular necrosis (HP:0001404)2.11563921
89Vaginal atresia (HP:0000148)2.09448146
90Sloping forehead (HP:0000340)2.08695007
91Microvesicular hepatic steatosis (HP:0001414)2.08038797
92Volvulus (HP:0002580)2.07301502
93Abnormality of the carotid arteries (HP:0005344)2.06897908
94Atelectasis (HP:0100750)2.04956844
95Embryonal renal neoplasm (HP:0011794)2.03640330
96Chromosomal breakage induced by crosslinking agents (HP:0003221)2.01443490
97Truncal ataxia (HP:0002078)2.01418200
98Horseshoe kidney (HP:0000085)2.01141491
99Generalized hypopigmentation of hair (HP:0011358)2.00879437
100Poor coordination (HP:0002370)1.99459638
101Hepatic necrosis (HP:0002605)1.98747491
102Abnormality of the umbilical cord (HP:0010881)1.98482084
103Absence seizures (HP:0002121)1.98326853
104Cerebral hypomyelination (HP:0006808)1.97918332
105Abnormality of sulfur amino acid metabolism (HP:0004339)1.96445163
106Generalized tonic-clonic seizures (HP:0002069)1.95881646
107Akinesia (HP:0002304)1.94995809
108Anxiety (HP:0000739)1.93026490
109Limb dystonia (HP:0002451)1.92979195
110Secondary amenorrhea (HP:0000869)1.92723463
111Thyroid-stimulating hormone excess (HP:0002925)1.91698825
112Lissencephaly (HP:0001339)1.91450823
113Progressive muscle weakness (HP:0003323)1.91432384
114Exercise-induced muscle cramps (HP:0003710)1.90660086
115Abnormality of aspartate family amino acid metabolism (HP:0010899)1.90553480
116Abnormal respiratory motile cilium physiology (HP:0012261)1.89863690
117Absent radius (HP:0003974)1.89842823
118Medulloblastoma (HP:0002885)1.89078056
119Myelodysplasia (HP:0002863)1.88861273
120Triphalangeal thumb (HP:0001199)1.88390504
121Facial cleft (HP:0002006)1.88364233
122Methylmalonic acidemia (HP:0002912)1.86578338
123Bifid tongue (HP:0010297)1.86426941
124Ependymoma (HP:0002888)1.86085940
125Type I transferrin isoform profile (HP:0003642)1.84970485
126White forelock (HP:0002211)1.84855873
127Progressive external ophthalmoplegia (HP:0000590)1.84702572
128Hemiparesis (HP:0001269)1.84323486
129Optic neuritis (HP:0100653)1.83492301
130Retrobulbar optic neuritis (HP:0100654)1.83492301
131Abnormal number of incisors (HP:0011064)1.83433499
132Acute necrotizing encephalopathy (HP:0006965)1.83117884
133Colon cancer (HP:0003003)1.82042354
134Specific learning disability (HP:0001328)1.81983079
135Neoplasm of the adrenal gland (HP:0100631)1.81823334
136Widely spaced teeth (HP:0000687)1.81573095
137Absent forearm bone (HP:0003953)1.79111130
138Aplasia involving forearm bones (HP:0009822)1.79111130
139Aplasia/Hypoplasia of the tibia (HP:0005772)1.78785883
140Abnormalities of placenta or umbilical cord (HP:0001194)1.76698994
141Growth hormone deficiency (HP:0000824)1.76013308
142Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.75706718
143Aplasia/Hypoplasia of the brainstem (HP:0007362)1.75359312
144Hypoplasia of the brainstem (HP:0002365)1.75359312
145Progressive inability to walk (HP:0002505)1.74916573
146Excessive salivation (HP:0003781)1.74848692
147Drooling (HP:0002307)1.74848692
148Visual hallucinations (HP:0002367)1.74537092
149Premature ovarian failure (HP:0008209)1.73926310
150Agitation (HP:0000713)1.73745037
151Rhabdomyosarcoma (HP:0002859)1.73270983
152Poor suck (HP:0002033)1.72679397
153Abnormality of cells of the erythroid lineage (HP:0012130)1.72581023
154Neoplasm of the colon (HP:0100273)1.72219769
155Generalized hypopigmentation (HP:0007513)1.71637415
156Slow saccadic eye movements (HP:0000514)1.70646216
157Absent thumb (HP:0009777)1.70058520
158Impaired smooth pursuit (HP:0007772)1.68339631
159Spastic diplegia (HP:0001264)1.67338414
160Postnatal microcephaly (HP:0005484)1.66511179
161Ectopic kidney (HP:0000086)1.65701350
162Genetic anticipation (HP:0003743)1.65627282
163Polyphagia (HP:0002591)1.65531409
164Hypoplasia of the fovea (HP:0007750)1.65168945
165Aplasia/Hypoplasia of the fovea (HP:0008060)1.65168945
166Congenital hepatic fibrosis (HP:0002612)1.65165368
167Nasal speech (HP:0001611)1.63914248
168Fetal akinesia sequence (HP:0001989)1.63488178
169Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.63075620
170Decreased activity of mitochondrial respiratory chain (HP:0008972)1.63075620
171Decreased central vision (HP:0007663)1.62470334
172Abnormality of salivation (HP:0100755)1.62375734
173Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.62363042
174Abnormal number of erythroid precursors (HP:0012131)1.62017420
175Megaloblastic anemia (HP:0001889)1.61756360
176Macrocytic anemia (HP:0001972)1.61700423
177Impaired vibration sensation in the lower limbs (HP:0002166)1.61696622
178Pancreatic cysts (HP:0001737)1.61294006
179Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.60805581
180Epileptiform EEG discharges (HP:0011182)1.60328769
181Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.60244587
182Degeneration of the lateral corticospinal tracts (HP:0002314)1.60244587
183Bradycardia (HP:0001662)1.59916175
184Respiratory failure (HP:0002878)1.59735989
185Gonadotropin excess (HP:0000837)1.59039646
186Increased IgM level (HP:0003496)1.58908343
187Abnormality of the fovea (HP:0000493)1.58824256
188Optic disc pallor (HP:0000543)1.58823151
189Ovarian neoplasm (HP:0100615)1.58741833
190Short tibia (HP:0005736)1.58617204
191Arteriovenous malformation (HP:0100026)1.57031995
192Supernumerary spleens (HP:0009799)1.56434793
193Leukodystrophy (HP:0002415)1.55249729
194Choanal atresia (HP:0000453)1.54674801

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK4.70271578
2BUB14.52617974
3NEK14.05567762
4TNIK3.99126764
5CDC73.37413085
6TTK3.23198219
7PBK3.16280387
8SIK33.08377337
9NTRK32.94468152
10MAP2K72.60416476
11TSSK62.56320089
12TRIM282.46794530
13EIF2AK12.45129734
14MAP3K122.42712744
15PLK32.36330376
16PLK42.23932956
17WEE12.18213724
18EPHA42.17631118
19BRSK22.16319445
20RIPK42.02271304
21MAP3K41.99553639
22PRPF4B1.98224208
23PLK11.91748409
24INSRR1.91682172
25SGK21.88297800
26VRK21.86748473
27BMPR21.83161921
28MAPK131.80830487
29MST41.79251386
30BCR1.77970146
31TIE11.74045630
32AKT31.73661658
33BMPR1B1.71272139
34BRSK11.69546708
35NEK61.66194120
36SGK2231.62827778
37SGK4941.62827778
38MARK11.61135243
39ZAK1.52647244
40NME21.50728747
41CCNB11.42912575
42NEK21.42613929
43TXK1.41541810
44PDK21.39919166
45LATS11.34763180
46NTRK21.32532720
47CHEK21.31454989
48ATR1.30670633
49MAP3K131.27003624
50AURKB1.26189268
51GRK11.25101050
52GRK71.19262366
53VRK11.15817342
54IRAK41.15113916
55YES11.14461749
56DYRK31.14238640
57MAP3K141.11645146
58BRD41.10649823
59WNK31.09042717
60UHMK11.06466405
61MUSK1.05908201
62FES1.05766501
63STK161.05571123
64OXSR11.05065859
65ERBB31.04662831
66CHEK11.04086494
67BCKDK0.99831147
68TNK20.98735190
69SGK30.98395793
70NME10.96133638
71CDK190.95078058
72AURKA0.91552003
73PRKCG0.89985198
74ATM0.89229565
75SCYL20.88726536
76PIK3CG0.88530484
77MINK10.88498058
78PLK20.87962465
79PRKCE0.85231311
80EIF2AK30.85035507
81KSR10.84025343
82CAMK2B0.82857475
83CDK70.82701316
84ACVR1B0.82649117
85SGK10.82455983
86TAF10.81286671
87EIF2AK20.79457004
88PINK10.78232158
89CDK50.77543822
90MKNK20.77125822
91PAK40.76593818
92ALK0.76303210
93TEC0.76020780
94CSNK1G10.75781804
95RPS6KB20.74127967
96CAMK2A0.73388007
97MAP2K40.73130580
98ADRBK20.72917059
99CSNK1G30.72531942
100DAPK20.71544791
101STK30.71273806
102DYRK1A0.71103702
103DAPK10.70295121
104SYK0.69777051
105CDK10.68463025
106CDK30.66699893
107OBSCN0.66171237
108PNCK0.65587651
109SIK20.65207325
110SRPK10.63532844
111ERBB40.62748238
112CLK10.61969719
113CSNK1A1L0.61950536
114PKN10.61702992
115CSNK2A20.61469796
116STK40.61422881
117CSNK2A10.61060207
118CSNK1G20.59146566
119RPS6KA40.58658840
120CAMK10.58356740
121CSNK1E0.57579649
122* CDK20.57229938
123BRAF0.55341066
124STK38L0.54488713
125MAP3K80.54432034
126LIMK10.54251243
127PRKG10.53449233
128PRKCQ0.47415508
129CDK80.46587647
130PTK2B0.46283482
131MKNK10.45387545
132LYN0.44912947
133MARK20.44552289
134CDK90.43348346
135MAPKAPK50.42872252
136PRKDC0.42648151
137PRKACA0.41849728
138NUAK10.39972517
139MAPK150.39745549
140PASK0.39658219
141ADRBK10.39656323
142FGR0.39201104
143LATS20.39150208
144STK100.39008891
145GRK50.37965310
146KDR0.37447793
147RPS6KB10.37129676
148DYRK20.36703652
149IKBKE0.36463234
150IKBKB0.35882206
151IRAK20.33878879
152CDK140.33870535
153AKT20.33395854
154JAK30.32948358
155FGFR10.32872621
156PAK10.32578287
157CDK150.31015327
158PIK3CA0.30660616
159CSNK1A10.30057520
160CDC42BPA0.29877857
161MELK0.29483040
162ILK0.29282924
163FYN0.29145745
164CDK180.29113105
165PRKCA0.29011064
166PRKCB0.27501060
167CAMK2D0.27413285
168CDK11A0.26006338
169PHKG10.25804519
170PHKG20.25804519
171RAF10.25752657

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.31042346
2DNA replication_Homo sapiens_hsa030303.60417302
3Mismatch repair_Homo sapiens_hsa034303.19167930
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.90034446
5Morphine addiction_Homo sapiens_hsa050322.75979524
6Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.74729694
7Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.54840094
8One carbon pool by folate_Homo sapiens_hsa006702.53600862
9Synaptic vesicle cycle_Homo sapiens_hsa047212.52990510
10Glutamatergic synapse_Homo sapiens_hsa047242.48138819
11Taste transduction_Homo sapiens_hsa047422.45740421
12Collecting duct acid secretion_Homo sapiens_hsa049662.42608145
13Spliceosome_Homo sapiens_hsa030402.33773981
14Circadian entrainment_Homo sapiens_hsa047132.32676170
15Homologous recombination_Homo sapiens_hsa034402.29974975
16GABAergic synapse_Homo sapiens_hsa047272.29824340
17SNARE interactions in vesicular transport_Homo sapiens_hsa041302.29710182
18RNA polymerase_Homo sapiens_hsa030202.27150556
19Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.24762859
20Base excision repair_Homo sapiens_hsa034102.24286844
21RNA transport_Homo sapiens_hsa030132.20599394
22Olfactory transduction_Homo sapiens_hsa047402.15902545
23Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.10014844
24Serotonergic synapse_Homo sapiens_hsa047262.08537681
25Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.07919468
26Cell cycle_Homo sapiens_hsa041102.06247627
27Nucleotide excision repair_Homo sapiens_hsa034202.03039282
28Amphetamine addiction_Homo sapiens_hsa050311.98928621
29Ribosome_Homo sapiens_hsa030101.88798484
30Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.85458550
312-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.84596037
32Cysteine and methionine metabolism_Homo sapiens_hsa002701.80407480
33Rheumatoid arthritis_Homo sapiens_hsa053231.78293038
34Long-term potentiation_Homo sapiens_hsa047201.77826596
35Pyruvate metabolism_Homo sapiens_hsa006201.77368717
36Dopaminergic synapse_Homo sapiens_hsa047281.73694032
37Insulin secretion_Homo sapiens_hsa049111.69658482
38Propanoate metabolism_Homo sapiens_hsa006401.69602438
39Type I diabetes mellitus_Homo sapiens_hsa049401.66224816
40Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.64731257
41Oxidative phosphorylation_Homo sapiens_hsa001901.61811004
42Pyrimidine metabolism_Homo sapiens_hsa002401.60085957
43RNA degradation_Homo sapiens_hsa030181.59929522
44Vibrio cholerae infection_Homo sapiens_hsa051101.57466526
45Phototransduction_Homo sapiens_hsa047441.56087403
46Protein export_Homo sapiens_hsa030601.53403850
47Calcium signaling pathway_Homo sapiens_hsa040201.52539189
48Biosynthesis of amino acids_Homo sapiens_hsa012301.49780610
49Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.49372981
50Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.47692223
51Cocaine addiction_Homo sapiens_hsa050301.46212461
52Long-term depression_Homo sapiens_hsa047301.42694761
53Cholinergic synapse_Homo sapiens_hsa047251.41738212
54Carbon metabolism_Homo sapiens_hsa012001.41706974
55Salivary secretion_Homo sapiens_hsa049701.37390536
56Vitamin B6 metabolism_Homo sapiens_hsa007501.35617442
57Phosphatidylinositol signaling system_Homo sapiens_hsa040701.34024431
58Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.33665624
59Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.31080376
60Steroid biosynthesis_Homo sapiens_hsa001001.27859322
61mRNA surveillance pathway_Homo sapiens_hsa030151.26422928
62Fatty acid elongation_Homo sapiens_hsa000621.25248471
63Autoimmune thyroid disease_Homo sapiens_hsa053201.18734778
64Aldosterone synthesis and secretion_Homo sapiens_hsa049251.15745636
65Folate biosynthesis_Homo sapiens_hsa007901.15650514
66Sulfur relay system_Homo sapiens_hsa041221.13803716
67Renin secretion_Homo sapiens_hsa049241.08243684
68Alzheimers disease_Homo sapiens_hsa050101.07811863
69Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.06493716
70Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.06473802
71Axon guidance_Homo sapiens_hsa043601.06316449
72Allograft rejection_Homo sapiens_hsa053301.05641680
73Oocyte meiosis_Homo sapiens_hsa041141.04569391
74Sphingolipid metabolism_Homo sapiens_hsa006001.03172772
75Selenocompound metabolism_Homo sapiens_hsa004501.01811782
76Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.01801485
77Gastric acid secretion_Homo sapiens_hsa049710.99727996
78Phagosome_Homo sapiens_hsa041450.98979305
79African trypanosomiasis_Homo sapiens_hsa051430.98514988
80Parkinsons disease_Homo sapiens_hsa050120.94152981
81Non-homologous end-joining_Homo sapiens_hsa034500.89991999
82Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.89984049
83Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.89959161
84cAMP signaling pathway_Homo sapiens_hsa040240.89540655
85Glutathione metabolism_Homo sapiens_hsa004800.88456416
86Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.87701978
87Type II diabetes mellitus_Homo sapiens_hsa049300.87395990
88Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.85951175
89Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.85471337
90Sulfur metabolism_Homo sapiens_hsa009200.83812273
91Circadian rhythm_Homo sapiens_hsa047100.83520344
92Inositol phosphate metabolism_Homo sapiens_hsa005620.83423532
93Oxytocin signaling pathway_Homo sapiens_hsa049210.81577169
94Asthma_Homo sapiens_hsa053100.80561247
95Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.80478645
96Basal transcription factors_Homo sapiens_hsa030220.78727679
97Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.75945147
98Graft-versus-host disease_Homo sapiens_hsa053320.74197587
99Fatty acid metabolism_Homo sapiens_hsa012120.74180054
100Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.71545436
101GnRH signaling pathway_Homo sapiens_hsa049120.71509334
102Huntingtons disease_Homo sapiens_hsa050160.71475411
103Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.70050207
104Metabolic pathways_Homo sapiens_hsa011000.69526360
105Arginine biosynthesis_Homo sapiens_hsa002200.69481232
106p53 signaling pathway_Homo sapiens_hsa041150.68388769
107Maturity onset diabetes of the young_Homo sapiens_hsa049500.67236642
108NF-kappa B signaling pathway_Homo sapiens_hsa040640.66754544
109Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.65398164
110Arginine and proline metabolism_Homo sapiens_hsa003300.64002419
111Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.63822995
112Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.63726656
113NOD-like receptor signaling pathway_Homo sapiens_hsa046210.63571358
114Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.62509601
115Pentose phosphate pathway_Homo sapiens_hsa000300.61432851
116Butanoate metabolism_Homo sapiens_hsa006500.61334614
117MAPK signaling pathway_Homo sapiens_hsa040100.60776564
118ErbB signaling pathway_Homo sapiens_hsa040120.60359831
119Vascular smooth muscle contraction_Homo sapiens_hsa042700.60044600
120Pentose and glucuronate interconversions_Homo sapiens_hsa000400.59350046
121Peroxisome_Homo sapiens_hsa041460.57870919
122Regulation of autophagy_Homo sapiens_hsa041400.57758699
123Intestinal immune network for IgA production_Homo sapiens_hsa046720.57637462
124Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.57144091
125Lysine degradation_Homo sapiens_hsa003100.56365339
126Fatty acid degradation_Homo sapiens_hsa000710.56121501
127Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.55603418
128Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.54303369
129Pancreatic secretion_Homo sapiens_hsa049720.54058675
130Hematopoietic cell lineage_Homo sapiens_hsa046400.51896781
131Chemokine signaling pathway_Homo sapiens_hsa040620.51793680
132Primary immunodeficiency_Homo sapiens_hsa053400.51180083
133Alcoholism_Homo sapiens_hsa050340.50295076
134N-Glycan biosynthesis_Homo sapiens_hsa005100.49442816
135Galactose metabolism_Homo sapiens_hsa000520.49062705
136Ovarian steroidogenesis_Homo sapiens_hsa049130.47949609
137Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.46642824
138Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.46217018
139Choline metabolism in cancer_Homo sapiens_hsa052310.46059855
140Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.45229114
141Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.45048603
142Gap junction_Homo sapiens_hsa045400.44204300
143Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.43608696
144Ether lipid metabolism_Homo sapiens_hsa005650.42755906
145Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.42082267
146Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.41903114
147Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.41748070
148Drug metabolism - other enzymes_Homo sapiens_hsa009830.40269791
149Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.39413260
150Toll-like receptor signaling pathway_Homo sapiens_hsa046200.38602575
151cGMP-PKG signaling pathway_Homo sapiens_hsa040220.38057019
152Ras signaling pathway_Homo sapiens_hsa040140.37312570
153Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.37138249
154Thyroid cancer_Homo sapiens_hsa052160.36842837
155Fructose and mannose metabolism_Homo sapiens_hsa000510.36224901
156RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.34758433
157Tuberculosis_Homo sapiens_hsa051520.34619130
158Fanconi anemia pathway_Homo sapiens_hsa034600.34193477
159Cardiac muscle contraction_Homo sapiens_hsa042600.33348330
160Purine metabolism_Homo sapiens_hsa002300.33161433
161Proteasome_Homo sapiens_hsa030500.33083215
162Measles_Homo sapiens_hsa051620.32621470
163Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.31041642
164Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.30009099
165Hippo signaling pathway_Homo sapiens_hsa043900.27164418
166Primary bile acid biosynthesis_Homo sapiens_hsa001200.25512396
167beta-Alanine metabolism_Homo sapiens_hsa004100.25264002
168Adherens junction_Homo sapiens_hsa045200.24815571
169Tryptophan metabolism_Homo sapiens_hsa003800.20322708
170Hedgehog signaling pathway_Homo sapiens_hsa043400.17248055
171Tyrosine metabolism_Homo sapiens_hsa003500.16890352
172Retinol metabolism_Homo sapiens_hsa008300.16780579
173Epstein-Barr virus infection_Homo sapiens_hsa051690.15669411
174Starch and sucrose metabolism_Homo sapiens_hsa005000.15496768
175Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.15424047
176Wnt signaling pathway_Homo sapiens_hsa043100.14709208
177Basal cell carcinoma_Homo sapiens_hsa052170.14683052
178TGF-beta signaling pathway_Homo sapiens_hsa043500.13502073
179Central carbon metabolism in cancer_Homo sapiens_hsa052300.12607903
180Tight junction_Homo sapiens_hsa045300.10369900
181Nitrogen metabolism_Homo sapiens_hsa009100.10041622

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