TBC1D7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the TBC-domain containing protein family. The encoded protein functions as a subunit of the tuberous sclerosis TSC1-TSC2 complex which plays a role in the regulation of cellular growth and differentiation. Mutations in this gene have been associated with autosomal recessive megalencephaly. Alternative splicing results in multiple transcript variants. Naturally occurring readthrough transcription occurs between this locus and downstream LOC100130357. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1melanin biosynthetic process (GO:0042438)9.30494881
2melanin metabolic process (GO:0006582)8.36105263
3secondary metabolite biosynthetic process (GO:0044550)8.36005252
4mitochondrial ATP synthesis coupled proton transport (GO:0042776)7.24276003
5ATP synthesis coupled proton transport (GO:0015986)6.92165864
6energy coupled proton transport, down electrochemical gradient (GO:0015985)6.92165864
7chaperone-mediated protein transport (GO:0072321)6.35011640
8mitochondrial electron transport, NADH to ubiquinone (GO:0006120)5.76722080
9cullin deneddylation (GO:0010388)5.71770715
10respiratory electron transport chain (GO:0022904)5.29137012
11protein deneddylation (GO:0000338)5.21602872
12electron transport chain (GO:0022900)5.14353974
13protein neddylation (GO:0045116)4.68714704
14mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.61142462
15mitochondrial respiratory chain complex I assembly (GO:0032981)4.61142462
16NADH dehydrogenase complex assembly (GO:0010257)4.61142462
17protein complex biogenesis (GO:0070271)4.53486097
18melanosome organization (GO:0032438)4.37191718
19L-methionine biosynthetic process from methylthioadenosine (GO:0019509)4.28602340
20pigment granule organization (GO:0048753)4.08129343
21mitochondrial respiratory chain complex assembly (GO:0033108)4.03585826
22phenol-containing compound biosynthetic process (GO:0046189)3.91136386
23establishment of protein localization to mitochondrial membrane (GO:0090151)3.87601806
24proteasome assembly (GO:0043248)3.81784971
25GTP biosynthetic process (GO:0006183)3.78989869
26DNA deamination (GO:0045006)3.71389267
27purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.68486399
28ATP biosynthetic process (GO:0006754)3.65485408
29purine nucleoside triphosphate biosynthetic process (GO:0009145)3.65151081
30transcription elongation from RNA polymerase III promoter (GO:0006385)3.58524944
31termination of RNA polymerase III transcription (GO:0006386)3.58524944
32mannosylation (GO:0097502)3.58137294
33oxidative phosphorylation (GO:0006119)3.56847155
34fatty acid elongation (GO:0030497)3.55689475
35ketone body metabolic process (GO:1902224)3.54209233
36regulation of DNA endoreduplication (GO:0032875)3.49363843
37melanocyte differentiation (GO:0030318)3.47967829
38peptidyl-histidine modification (GO:0018202)3.42930899
39tyrosine metabolic process (GO:0006570)3.42573811
40pigment biosynthetic process (GO:0046148)3.39329648
41negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.38260809
42pigment cell differentiation (GO:0050931)3.35897943
43guanosine-containing compound biosynthetic process (GO:1901070)3.34999657
44hydrogen ion transmembrane transport (GO:1902600)3.34331463
45L-methionine salvage (GO:0071267)3.34144888
46L-methionine biosynthetic process (GO:0071265)3.34144888
47amino acid salvage (GO:0043102)3.34144888
48piRNA metabolic process (GO:0034587)3.32445948
49inner mitochondrial membrane organization (GO:0007007)3.29820612
50ribonucleoside triphosphate biosynthetic process (GO:0009201)3.27429842
51replication fork processing (GO:0031297)3.25136141
52protein targeting to mitochondrion (GO:0006626)3.23914350
53cornea development in camera-type eye (GO:0061303)3.21946853
54inositol phosphate catabolic process (GO:0071545)3.21241501
55synapsis (GO:0007129)3.19578700
56neuroepithelial cell differentiation (GO:0060563)3.19445858
57DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.19314898
58UTP biosynthetic process (GO:0006228)3.15621239
59regulation of cellular amino acid metabolic process (GO:0006521)3.14978810
60establishment of protein localization to mitochondrion (GO:0072655)3.14462692
61signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.12831255
62intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.12831255
63negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.12819508
64negative regulation of ligase activity (GO:0051352)3.12819508
65positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.11473838
66tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.10672854
67RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.10672854
68detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.09814595
69signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.09791566
70signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.09791566
71signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.09791566
727-methylguanosine mRNA capping (GO:0006370)3.05918302
73RNA capping (GO:0036260)3.05896764
747-methylguanosine RNA capping (GO:0009452)3.05896764
75respiratory chain complex IV assembly (GO:0008535)3.05647291
76deoxyribonucleoside diphosphate metabolic process (GO:0009186)3.05116279
77protein-cofactor linkage (GO:0018065)3.03881615
78regulation of mitochondrial translation (GO:0070129)3.03028613
79water-soluble vitamin biosynthetic process (GO:0042364)3.02576302
80phosphorylated carbohydrate dephosphorylation (GO:0046838)3.00806310
81inositol phosphate dephosphorylation (GO:0046855)3.00806310
82DNA double-strand break processing (GO:0000729)3.00513296
83signal transduction involved in cell cycle checkpoint (GO:0072395)2.99406672
84exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.98709397
85signal transduction involved in DNA integrity checkpoint (GO:0072401)2.98319352
86signal transduction involved in DNA damage checkpoint (GO:0072422)2.98319352
87recombinational repair (GO:0000725)2.97739104
88ATP hydrolysis coupled proton transport (GO:0015991)2.96106212
89energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.96106212
90nucleoside triphosphate biosynthetic process (GO:0009142)2.95361146
91behavioral response to nicotine (GO:0035095)2.93698302
92double-strand break repair via homologous recombination (GO:0000724)2.93481171
93aerobic respiration (GO:0009060)2.92435088
94proton transport (GO:0015992)2.90965204
95DNA damage response, detection of DNA damage (GO:0042769)2.90794684
96regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.90629252
97nucleobase-containing small molecule interconversion (GO:0015949)2.89892822
98DNA methylation involved in gamete generation (GO:0043046)2.88660283
99response to pheromone (GO:0019236)2.88657367
100pigment metabolic process (GO:0042440)2.88098737
101maturation of 5.8S rRNA (GO:0000460)2.86789894
102developmental pigmentation (GO:0048066)2.86626553
103G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.86109365
104regulation of oxidative phosphorylation (GO:0002082)2.85503080
105positive regulation of mitochondrial fission (GO:0090141)2.83203152
106protein localization to mitochondrion (GO:0070585)2.82460159
107establishment of integrated proviral latency (GO:0075713)2.82392370
108formation of translation preinitiation complex (GO:0001731)2.82192449
109hydrogen transport (GO:0006818)2.82110729
110regulation of cellular respiration (GO:0043457)2.80195929
111anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.79922621
112platelet dense granule organization (GO:0060155)2.79223783
113CTP biosynthetic process (GO:0006241)2.78397706
114CTP metabolic process (GO:0046036)2.78397706
115regulation of mitotic spindle checkpoint (GO:1903504)2.76915007
116regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.76915007
117chromatin remodeling at centromere (GO:0031055)2.75446862
118negative regulation of microtubule polymerization (GO:0031115)2.75377497
119preassembly of GPI anchor in ER membrane (GO:0016254)2.75328403
120negative regulation of DNA-dependent DNA replication (GO:2000104)2.74429313
121UTP metabolic process (GO:0046051)2.73271068
122CENP-A containing nucleosome assembly (GO:0034080)2.72800563
123de novo posttranslational protein folding (GO:0051084)2.72656994
124intraciliary transport (GO:0042073)2.72349826
125de novo protein folding (GO:0006458)2.72011703
126establishment of mitochondrion localization (GO:0051654)2.71195893
127substantia nigra development (GO:0021762)2.70786707
128spliceosomal snRNP assembly (GO:0000387)2.69757800
129protein polyglutamylation (GO:0018095)2.68224219
130positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.67094948
131RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.66990494
132spliceosomal complex assembly (GO:0000245)2.65863536
133heart process (GO:0003015)2.65107127
134heart contraction (GO:0060047)2.65107127
135negative regulation of tumor necrosis factor-mediated signaling pathway (GO:0010804)2.65080942
136resolution of meiotic recombination intermediates (GO:0000712)2.64636357
137ubiquinone biosynthetic process (GO:0006744)2.62658744
138microtubule polymerization or depolymerization (GO:0031109)2.62579274
139signal peptide processing (GO:0006465)2.62025859
140protein K6-linked ubiquitination (GO:0085020)2.61472544
141polyol catabolic process (GO:0046174)2.61281609
142reciprocal DNA recombination (GO:0035825)2.60216334
143reciprocal meiotic recombination (GO:0007131)2.60216334
144nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.60080350
145melanosome transport (GO:0032402)2.59469959
146purine nucleoside monophosphate biosynthetic process (GO:0009127)2.58669828
147purine ribonucleoside monophosphate biosynthetic process (GO:0009168)2.58669828
148nucleoside diphosphate phosphorylation (GO:0006165)2.57836396
149deoxyribonucleotide biosynthetic process (GO:0009263)2.56775702
150GPI anchor metabolic process (GO:0006505)2.56732973
151secondary metabolic process (GO:0019748)2.56339208
152positive regulation of ligase activity (GO:0051351)2.55952955
153negative regulation of telomere maintenance (GO:0032205)2.55359176
154mitochondrial transport (GO:0006839)2.54432114
155retinal rod cell development (GO:0046548)2.54204977
156cytochrome complex assembly (GO:0017004)2.53556459
157melanosome localization (GO:0032400)2.53503402
158ubiquinone metabolic process (GO:0006743)2.52941294
159sulfation (GO:0051923)2.52561494
160antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.52200090
161establishment of melanosome localization (GO:0032401)2.49639029
162endosome to melanosome transport (GO:0035646)2.48546570
163endosome to pigment granule transport (GO:0043485)2.48546570
164dolichol-linked oligosaccharide biosynthetic process (GO:0006488)2.47149908
165centriole replication (GO:0007099)2.46853397
166neural tube formation (GO:0001841)2.45520439
167dopamine transport (GO:0015872)2.45446552
168histone exchange (GO:0043486)2.45264696
169negative regulation of membrane potential (GO:0045837)2.45047081

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.45210996
2GABP_17652178_ChIP-ChIP_JURKAT_Human3.90929320
3EST1_17652178_ChIP-ChIP_JURKAT_Human3.79115738
4* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.72709487
5NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.46716806
6HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.24953606
7HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.17859541
8ZNF274_21170338_ChIP-Seq_K562_Hela2.97671792
9CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.94245376
10ETS1_20019798_ChIP-Seq_JURKAT_Human2.90986253
11CREB1_15753290_ChIP-ChIP_HEK293T_Human2.82177379
12PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.79984511
13SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.76974928
14* THAP11_20581084_ChIP-Seq_MESCs_Mouse2.75436413
15SRF_21415370_ChIP-Seq_HL-1_Mouse2.48498357
16MYC_18555785_ChIP-Seq_MESCs_Mouse2.25048869
17YY1_21170310_ChIP-Seq_MESCs_Mouse2.20507390
18POU3F2_20337985_ChIP-ChIP_501MEL_Human2.15601637
19* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.10305088
20EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.10087750
21TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.04500797
22TAF15_26573619_Chip-Seq_HEK293_Human2.02759629
23E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.01777230
24GBX2_23144817_ChIP-Seq_PC3_Human1.96672191
25VDR_22108803_ChIP-Seq_LS180_Human1.95456620
26HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.94033995
27DCP1A_22483619_ChIP-Seq_HELA_Human1.91686066
28E2F1_18555785_ChIP-Seq_MESCs_Mouse1.81668109
29ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.81450363
30* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.80750372
31RBPJ_22232070_ChIP-Seq_NCS_Mouse1.77186246
32BMI1_23680149_ChIP-Seq_NPCS_Mouse1.73245727
33TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.70338553
34YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.69977921
35VDR_23849224_ChIP-Seq_CD4+_Human1.69666038
36MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.66709865
37EZH2_22144423_ChIP-Seq_EOC_Human1.65033371
38XRN2_22483619_ChIP-Seq_HELA_Human1.63447117
39FOXP3_21729870_ChIP-Seq_TREG_Human1.62276283
40FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.58430722
41* ELK1_19687146_ChIP-ChIP_HELA_Human1.57323160
42ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.56145906
43EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.55934999
44TTF2_22483619_ChIP-Seq_HELA_Human1.51333080
45CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.49004585
46* GABP_19822575_ChIP-Seq_HepG2_Human1.47814768
47FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.46908115
48CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.46804236
49FUS_26573619_Chip-Seq_HEK293_Human1.45410654
50ELF1_17652178_ChIP-ChIP_JURKAT_Human1.44755070
51IGF1R_20145208_ChIP-Seq_DFB_Human1.44306559
52RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.44079107
53ER_23166858_ChIP-Seq_MCF-7_Human1.41375380
54CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.40188110
55UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.38642665
56PADI4_21655091_ChIP-ChIP_MCF-7_Human1.38491619
57FLI1_27457419_Chip-Seq_LIVER_Mouse1.37157384
58MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.35860660
59* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.34690869
60CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.32189867
61MYC_19079543_ChIP-ChIP_MESCs_Mouse1.30421816
62TP53_22573176_ChIP-Seq_HFKS_Human1.29872909
63CTBP2_25329375_ChIP-Seq_LNCAP_Human1.29783148
64NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.28248080
65ZFP57_27257070_Chip-Seq_ESCs_Mouse1.28010219
66DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.27760782
67CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.25975547
68GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.23859768
69POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.23662678
70SALL1_21062744_ChIP-ChIP_HESCs_Human1.23454474
71FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.23020382
72E2F7_22180533_ChIP-Seq_HELA_Human1.22982973
73CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.22216403
74CBP_20019798_ChIP-Seq_JUKART_Human1.21594426
75IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.21594426
76AUTS2_25519132_ChIP-Seq_293T-REX_Human1.21252082
77EZH2_27304074_Chip-Seq_ESCs_Mouse1.18634449
78SOX2_18555785_ChIP-Seq_MESCs_Mouse1.17688847
79EZH2_27294783_Chip-Seq_NPCs_Mouse1.17004845
80FOXA1_27270436_Chip-Seq_PROSTATE_Human1.15832516
81FOXA1_25329375_ChIP-Seq_VCAP_Human1.15832516
82PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.15725646
83MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.15670209
84AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.15243313
85ELK1_22589737_ChIP-Seq_MCF10A_Human1.13240933
86POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.12402685
87NFE2_27457419_Chip-Seq_LIVER_Mouse1.11274899
88IRF1_19129219_ChIP-ChIP_H3396_Human1.10739590
89HOXB4_20404135_ChIP-ChIP_EML_Mouse1.09487987
90KLF5_20875108_ChIP-Seq_MESCs_Mouse1.09487593
91CBX2_27304074_Chip-Seq_ESCs_Mouse1.09289452
92JUN_21703547_ChIP-Seq_K562_Human1.08701010
93RNF2_27304074_Chip-Seq_NSC_Mouse1.08506305
94TCF4_23295773_ChIP-Seq_U87_Human1.08215145
95* PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.07894606
96NCOR_22424771_ChIP-Seq_293T_Human1.07157722
97SOX17_20123909_ChIP-Seq_XEN_Mouse1.06881211
98EED_16625203_ChIP-ChIP_MESCs_Mouse1.06479080
99CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.06140056
100AR_25329375_ChIP-Seq_VCAP_Human1.05254660
101MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.03192906
102* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.03044105
103BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.03002343
104NANOG_19829295_ChIP-Seq_ESCs_Human1.02513890
105SOX2_19829295_ChIP-Seq_ESCs_Human1.02513890
106STAT3_23295773_ChIP-Seq_U87_Human1.01460331
107* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.01048034
108SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.00827480
109* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.00824963
110FOXA1_21572438_ChIP-Seq_LNCaP_Human1.00244111
111PCGF2_27294783_Chip-Seq_ESCs_Mouse1.00165808
112BCAT_22108803_ChIP-Seq_LS180_Human0.99979094
113SUZ12_27294783_Chip-Seq_NPCs_Mouse0.99632586
114* SMAD4_21799915_ChIP-Seq_A2780_Human0.99412894
115CRX_20693478_ChIP-Seq_RETINA_Mouse0.99307184
116GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.99187661
117MYC_18940864_ChIP-ChIP_HL60_Human0.98636532
118MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.98016700
119* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.97965992
120POU5F1_16153702_ChIP-ChIP_HESCs_Human0.97665159
121P300_19829295_ChIP-Seq_ESCs_Human0.97662635
122* KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.96884237
123TAL1_26923725_Chip-Seq_HPCs_Mouse0.96583827
124* REST_18959480_ChIP-ChIP_MESCs_Mouse0.96581316
125EWS_26573619_Chip-Seq_HEK293_Human0.95331790
126TCF4_22108803_ChIP-Seq_LS180_Human0.95200092
127SOX2_16153702_ChIP-ChIP_HESCs_Human0.95052652
128FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.94395675
129RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.94253723
130SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.93714431
131AR_20517297_ChIP-Seq_VCAP_Human0.92859863
132CTCF_18555785_ChIP-Seq_MESCs_Mouse0.92666756
133HOXB7_26014856_ChIP-Seq_BT474_Human0.92263072
134SMAD3_21741376_ChIP-Seq_EPCs_Human0.91595506
135TOP2B_26459242_ChIP-Seq_MCF-7_Human0.91587264
136FOXM1_23109430_ChIP-Seq_U2OS_Human0.91388699
137* SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.91327413
138REST_21632747_ChIP-Seq_MESCs_Mouse0.89556059
139SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.89409352
140GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.88997118
141JARID2_20075857_ChIP-Seq_MESCs_Mouse0.88429126
142SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.88356415
143OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.88197962
144JARID2_20064375_ChIP-Seq_MESCs_Mouse0.85615439
145E2F4_17652178_ChIP-ChIP_JURKAT_Human0.82763424
146SOX9_26525672_Chip-Seq_HEART_Mouse0.81571854

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005075_abnormal_melanosome_morpholog4.01287915
2MP0001529_abnormal_vocalization3.46053028
3MP0003880_abnormal_central_pattern3.17280169
4MP0002102_abnormal_ear_morphology3.14353618
5MP0002095_abnormal_skin_pigmentation2.99692190
6MP0005171_absent_coat_pigmentation2.87385879
7MP0005174_abnormal_tail_pigmentation2.64543768
8MP0002736_abnormal_nociception_after2.46728170
9MP0003122_maternal_imprinting2.43167478
10MP0000371_diluted_coat_color2.42525191
11MP0006292_abnormal_olfactory_placode2.35133517
12MP0006276_abnormal_autonomic_nervous2.23190208
13MP0000569_abnormal_digit_pigmentation2.22630994
14MP0004381_abnormal_hair_follicle2.18593738
15MP0001968_abnormal_touch/_nociception2.16823037
16MP0009697_abnormal_copulation2.07603873
17MP0001324_abnormal_eye_pigmentation2.00582040
18MP0008789_abnormal_olfactory_epithelium2.00346384
19MP0002735_abnormal_chemical_nociception1.94617210
20MP0002837_dystrophic_cardiac_calcinosis1.93944568
21MP0003011_delayed_dark_adaptation1.93813230
22MP0001905_abnormal_dopamine_level1.93773151
23MP0001984_abnormal_olfaction1.90736411
24MP0000749_muscle_degeneration1.89290642
25MP0000372_irregular_coat_pigmentation1.81751028
26MP0000778_abnormal_nervous_system1.71624047
27MP0002734_abnormal_mechanical_nocicepti1.70751449
28MP0005499_abnormal_olfactory_system1.70069313
29MP0005394_taste/olfaction_phenotype1.70069313
30MP0002272_abnormal_nervous_system1.69516054
31MP0003718_maternal_effect1.64016083
32MP0004270_analgesia1.63474520
33MP0002075_abnormal_coat/hair_pigmentati1.61757297
34MP0003123_paternal_imprinting1.61201340
35MP0000751_myopathy1.60217850
36MP0009379_abnormal_foot_pigmentation1.59532407
37MP0002653_abnormal_ependyma_morphology1.59418323
38MP0004142_abnormal_muscle_tone1.57343615
39MP0001188_hyperpigmentation1.55268273
40MP0005253_abnormal_eye_physiology1.55111336
41MP0002064_seizures1.52884149
42MP0003121_genomic_imprinting1.51015034
43MP0003646_muscle_fatigue1.49193325
44MP0006036_abnormal_mitochondrial_physio1.48872775
45MP0004036_abnormal_muscle_relaxation1.46604564
46MP0001186_pigmentation_phenotype1.45892606
47MP0003635_abnormal_synaptic_transmissio1.45875908
48MP0004885_abnormal_endolymph1.45838276
49MP0002090_abnormal_vision1.44068296
50MP0002184_abnormal_innervation1.43965537
51MP0002751_abnormal_autonomic_nervous1.43347337
52MP0010094_abnormal_chromosome_stability1.43032211
53MP0005503_abnormal_tendon_morphology1.42608076
54MP0003806_abnormal_nucleotide_metabolis1.42350552
55MP0002638_abnormal_pupillary_reflex1.39313770
56MP0009745_abnormal_behavioral_response1.36849708
57MP0005646_abnormal_pituitary_gland1.36837421
58MP0001970_abnormal_pain_threshold1.34608054
59MP0009046_muscle_twitch1.34342474
60MP0002572_abnormal_emotion/affect_behav1.33759875
61MP0002733_abnormal_thermal_nociception1.32034291
62MP0004858_abnormal_nervous_system1.27517526
63MP0002063_abnormal_learning/memory/cond1.27049941
64MP0004147_increased_porphyrin_level1.24482746
65MP0002067_abnormal_sensory_capabilities1.23451251
66MP0005409_darkened_coat_color1.22569871
67MP0002938_white_spotting1.22007816
68MP0004145_abnormal_muscle_electrophysio1.21944996
69MP0004084_abnormal_cardiac_muscle1.21633834
70MP0008932_abnormal_embryonic_tissue1.21625593
71MP0005386_behavior/neurological_phenoty1.21279324
72MP0004924_abnormal_behavior1.21279324
73MP0003693_abnormal_embryo_hatching1.20760604
74MP0006035_abnormal_mitochondrial_morpho1.20077858
75MP0004215_abnormal_myocardial_fiber1.18690102
76MP0003136_yellow_coat_color1.18263219
77MP0004859_abnormal_synaptic_plasticity1.17254202
78MP0006072_abnormal_retinal_apoptosis1.16886625
79MP0003878_abnormal_ear_physiology1.16387293
80MP0005377_hearing/vestibular/ear_phenot1.16387293
81MP0005551_abnormal_eye_electrophysiolog1.13714983
82MP0000631_abnormal_neuroendocrine_gland1.13172122
83MP0001485_abnormal_pinna_reflex1.09759615
84MP0002163_abnormal_gland_morphology1.09141616
85MP0002752_abnormal_somatic_nervous1.07569781
86MP0002882_abnormal_neuron_morphology1.06853801
87MP0003137_abnormal_impulse_conducting1.06053764
88MP0000015_abnormal_ear_pigmentation1.05206677
89MP0002877_abnormal_melanocyte_morpholog1.04451453
90MP0000049_abnormal_middle_ear1.03814649
91MP0005389_reproductive_system_phenotype1.03727355
92MP0004742_abnormal_vestibular_system1.03180424
93MP0002229_neurodegeneration1.01646136
94MP0001986_abnormal_taste_sensitivity1.01477098
95MP0005187_abnormal_penis_morphology1.01392725
96MP0008877_abnormal_DNA_methylation1.01298960
97MP0003567_abnormal_fetal_cardiomyocyte1.00976098
98MP0003950_abnormal_plasma_membrane0.97448705
99MP0001486_abnormal_startle_reflex0.97313175
100MP0010386_abnormal_urinary_bladder0.96666399
101MP0004233_abnormal_muscle_weight0.95564724
102MP0002160_abnormal_reproductive_system0.95150355
103MP0003315_abnormal_perineum_morphology0.95078637
104MP0003195_calcinosis0.94963943
105MP0002822_catalepsy0.94544172
106MP0005257_abnormal_intraocular_pressure0.93834078
107MP0000566_synostosis0.93188169
108MP0005408_hypopigmentation0.92920456
109MP0002066_abnormal_motor_capabilities/c0.92671816
110MP0001963_abnormal_hearing_physiology0.92559644
111MP0004085_abnormal_heartbeat0.91126665
112MP0000026_abnormal_inner_ear0.90823098
113MP0004133_heterotaxia0.89554822
114MP0000955_abnormal_spinal_cord0.89436653
115MP0002127_abnormal_cardiovascular_syste0.87762832
116MP0001727_abnormal_embryo_implantation0.87482492
117MP0003942_abnormal_urinary_system0.86022352
118MP0010030_abnormal_orbit_morphology0.85435758
119MP0000647_abnormal_sebaceous_gland0.84827775
120MP0002972_abnormal_cardiac_muscle0.83073832
121MP0003186_abnormal_redox_activity0.81710467
122MP0002557_abnormal_social/conspecific_i0.81640080
123MP0001293_anophthalmia0.81066803
124MP0008058_abnormal_DNA_repair0.79520242
125MP0005369_muscle_phenotype0.79058960
126MP0000920_abnormal_myelination0.78390031
127MP0001919_abnormal_reproductive_system0.77819532
128MP0005670_abnormal_white_adipose0.77580784
129MP0002152_abnormal_brain_morphology0.77228688
130MP0003787_abnormal_imprinting0.76996518
131MP0005645_abnormal_hypothalamus_physiol0.74762859
132MP0002177_abnormal_outer_ear0.74454408
133MP0005195_abnormal_posterior_eye0.71971837
134MP0002210_abnormal_sex_determination0.71349266
135MP0001929_abnormal_gametogenesis0.70350016
136MP0000427_abnormal_hair_cycle0.70121015
137MP0003698_abnormal_male_reproductive0.69547436
138MP0003786_premature_aging0.67783812
139MP0005410_abnormal_fertilization0.67778575
140MP0005248_abnormal_Harderian_gland0.66742185
141MP0008872_abnormal_physiological_respon0.66528896
142MP0005197_abnormal_uvea_morphology0.65771391
143MP0003111_abnormal_nucleus_morphology0.65125660
144MP0003077_abnormal_cell_cycle0.65046817
145MP0005391_vision/eye_phenotype0.63664055
146MP0000653_abnormal_sex_gland0.58116379
147MP0003119_abnormal_digestive_system0.58084626
148MP0003937_abnormal_limbs/digits/tail_de0.56608335
149MP0004957_abnormal_blastocyst_morpholog0.56053264

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)6.35782587
2Abnormal mitochondria in muscle tissue (HP:0008316)5.79799515
3Hypoplasia of the fovea (HP:0007750)5.45526700
4Aplasia/Hypoplasia of the fovea (HP:0008060)5.45526700
5Mitochondrial inheritance (HP:0001427)5.41853622
6Progressive macrocephaly (HP:0004481)5.25175685
7Aplasia/Hypoplasia of the macula (HP:0008059)5.00162373
8Hepatocellular necrosis (HP:0001404)4.86927249
9Acute encephalopathy (HP:0006846)4.84078765
10Abnormality of the fovea (HP:0000493)4.73314023
11Increased CSF lactate (HP:0002490)4.65379373
12Aplasia/Hypoplasia affecting the retina (HP:0008061)4.62876210
13Increased hepatocellular lipid droplets (HP:0006565)4.48496766
14Increased serum pyruvate (HP:0003542)4.47630874
15Abnormality of glycolysis (HP:0004366)4.47630874
16Hepatic necrosis (HP:0002605)4.36493609
17Renal Fanconi syndrome (HP:0001994)4.30440951
18Patchy hypopigmentation of hair (HP:0011365)4.28148535
19White forelock (HP:0002211)4.24306284
20Lipid accumulation in hepatocytes (HP:0006561)4.06488921
21Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.92399965
22Congenital stationary night blindness (HP:0007642)3.89599814
23Ocular albinism (HP:0001107)3.80410464
24Iris hypopigmentation (HP:0007730)3.67881701
25Exercise intolerance (HP:0003546)3.63960510
26Leukodystrophy (HP:0002415)3.60352782
27Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.57410957
28Cerebral hypomyelination (HP:0006808)3.53000348
29Optic disc pallor (HP:0000543)3.45049227
30Blue irides (HP:0000635)3.42316898
31Cerebral edema (HP:0002181)3.35641665
32Increased intramyocellular lipid droplets (HP:0012240)3.33635159
33Exertional dyspnea (HP:0002875)3.19087105
34Increased serum lactate (HP:0002151)3.16515274
35Pancreatic cysts (HP:0001737)3.13681071
36Respiratory failure (HP:0002878)3.09284315
37Lactic acidosis (HP:0003128)3.08861717
38Congenital sensorineural hearing impairment (HP:0008527)3.07162168
39Neuroendocrine neoplasm (HP:0100634)3.04170478
40Decreased central vision (HP:0007663)3.04110391
41Pheochromocytoma (HP:0002666)3.03507386
42Generalized hypopigmentation (HP:0007513)3.01844951
43Abnormality of renal resorption (HP:0011038)2.93593433
44Hypothermia (HP:0002045)2.93399218
45Pancreatic fibrosis (HP:0100732)2.86535003
46Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.85358629
47Decreased activity of mitochondrial respiratory chain (HP:0008972)2.85358629
48Abnormality of midbrain morphology (HP:0002418)2.76902475
49Molar tooth sign on MRI (HP:0002419)2.76902475
50Increased muscle lipid content (HP:0009058)2.76358196
51Albinism (HP:0001022)2.74075733
52Respiratory difficulties (HP:0002880)2.70113083
53Nephrogenic diabetes insipidus (HP:0009806)2.58220434
54Aplasia/Hypoplasia affecting the fundus (HP:0008057)2.51940817
55Unsteady gait (HP:0002317)2.45690102
56Medial flaring of the eyebrow (HP:0010747)2.45467205
57Abnormal hair whorl (HP:0010721)2.44843668
58Abnormality of alanine metabolism (HP:0010916)2.42043364
59Hyperalaninemia (HP:0003348)2.42043364
60Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.42043364
61Gait imbalance (HP:0002141)2.38339183
62Abnormal auditory evoked potentials (HP:0006958)2.37878109
63Aplasia/Hypoplasia of the uvula (HP:0010293)2.36878777
64Atonic seizures (HP:0010819)2.36508023
65Congenital primary aphakia (HP:0007707)2.34462455
66Pendular nystagmus (HP:0012043)2.34054258
673-Methylglutaconic aciduria (HP:0003535)2.31801546
68Vaginal atresia (HP:0000148)2.30732536
69Hypoplastic left heart (HP:0004383)2.26396692
70Genital tract atresia (HP:0001827)2.25637900
71Decreased electroretinogram (ERG) amplitude (HP:0000654)2.24347544
72Myokymia (HP:0002411)2.22630550
73Generalized aminoaciduria (HP:0002909)2.22140607
74CNS demyelination (HP:0007305)2.21367910
75Sensory axonal neuropathy (HP:0003390)2.19890475
76Hypopigmentation of the fundus (HP:0007894)2.19027915
77Abolished electroretinogram (ERG) (HP:0000550)2.17509887
78Abnormality of the anterior horn cell (HP:0006802)2.16834573
79Degeneration of anterior horn cells (HP:0002398)2.16834573
80Gaze-evoked nystagmus (HP:0000640)2.16411536
81Meckel diverticulum (HP:0002245)2.15563556
82Emotional lability (HP:0000712)2.15199810
83Abnormality of the ileum (HP:0001549)2.15004761
84Premature graying of hair (HP:0002216)2.14520002
85Nephronophthisis (HP:0000090)2.14506292
86Epileptic encephalopathy (HP:0200134)2.09429212
87Cutaneous melanoma (HP:0012056)2.05732825
88Glycosuria (HP:0003076)2.03777645
89Abnormality of urine glucose concentration (HP:0011016)2.03777645
90Hyperglycinemia (HP:0002154)2.03329767
91Abnormality of chromosome stability (HP:0003220)2.02148295
92Chromosomal breakage induced by crosslinking agents (HP:0003221)2.01437516
93Intestinal atresia (HP:0011100)2.00755009
94Absent thumb (HP:0009777)1.99212635
95X-linked dominant inheritance (HP:0001423)1.98804155
96Chromsome breakage (HP:0040012)1.96513442
97Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.96301211
98Degeneration of the lateral corticospinal tracts (HP:0002314)1.96301211
99Cholecystitis (HP:0001082)1.94386276
100Abnormal gallbladder physiology (HP:0012438)1.94386276
101Abnormality of the labia minora (HP:0012880)1.93646036
102Abnormality of the renal cortex (HP:0011035)1.92910749
103Abnormal lung lobation (HP:0002101)1.92655887
104Type II lissencephaly (HP:0007260)1.91202855
105Delusions (HP:0000746)1.90602842
106Methylmalonic acidemia (HP:0002912)1.90023597
107Small hand (HP:0200055)1.89875117
108Failure to thrive in infancy (HP:0001531)1.89310157
109Bifid tongue (HP:0010297)1.88368658
110Hyperphosphaturia (HP:0003109)1.87302929
111* Astigmatism (HP:0000483)1.87076812
112Freckling (HP:0001480)1.87062475
113Hyperventilation (HP:0002883)1.86827798
114Neoplasm of the adrenal gland (HP:0100631)1.84979281
115Retinal dysplasia (HP:0007973)1.84266137
116Hypoplastic heart (HP:0001961)1.83333686
117Abnormality of the septum pellucidum (HP:0007375)1.82859817
118Sclerocornea (HP:0000647)1.82189236
119Absent septum pellucidum (HP:0001331)1.82065817
120Absent rod-and cone-mediated responses on ERG (HP:0007688)1.81776527
121Abnormality of the renal medulla (HP:0100957)1.81586535
122Renal tubular dysfunction (HP:0000124)1.80613419
123Small intestinal stenosis (HP:0012848)1.79301490
124Duodenal stenosis (HP:0100867)1.79301490
125Type I transferrin isoform profile (HP:0003642)1.78960148
126Aganglionic megacolon (HP:0002251)1.78777887
127Methylmalonic aciduria (HP:0012120)1.78640657
128Septo-optic dysplasia (HP:0100842)1.77045856
129CNS hypomyelination (HP:0003429)1.75914962
130Abnormal protein glycosylation (HP:0012346)1.73671440
131Abnormal glycosylation (HP:0012345)1.73671440
132Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.73671440
133Abnormal protein N-linked glycosylation (HP:0012347)1.73671440
134Progressive inability to walk (HP:0002505)1.73243044
135Heterochromia iridis (HP:0001100)1.72346541
136Blindness (HP:0000618)1.71273463
137Lissencephaly (HP:0001339)1.71182215
138Abnormality of the preputium (HP:0100587)1.68943324
139Attenuation of retinal blood vessels (HP:0007843)1.68919376
140Palpitations (HP:0001962)1.68896111
141Abnormal rod and cone electroretinograms (HP:0008323)1.67060398
142Sloping forehead (HP:0000340)1.66683885
143Inability to walk (HP:0002540)1.65332110
144Median cleft lip (HP:0000161)1.64524750
145Cystic liver disease (HP:0006706)1.64184104
146Birth length less than 3rd percentile (HP:0003561)1.63485672
147Preaxial hand polydactyly (HP:0001177)1.63426781
148Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.63120432
149Abnormality of cells of the erythroid lineage (HP:0012130)1.61707668
150Irregular epiphyses (HP:0010582)1.60655625
151Autoamputation (HP:0001218)1.60434877
152Abnormal autonomic nervous system physiology (HP:0012332)1.60174318
153Amniotic constriction ring (HP:0009775)1.59871570
154Abnormality of placental membranes (HP:0011409)1.59871570
155Primary adrenal insufficiency (HP:0008207)1.57545725
156Aplasia/Hypoplasia of the tibia (HP:0005772)1.57430081
157Female pseudohermaphroditism (HP:0010458)1.56720243
158Short tibia (HP:0005736)1.56258145
159True hermaphroditism (HP:0010459)1.55890864
160Poor coordination (HP:0002370)1.53051910
161Parakeratosis (HP:0001036)1.52910825
162Polyphagia (HP:0002591)1.52376272
163Lethargy (HP:0001254)1.51965797
164Poor suck (HP:0002033)1.51747701
165Amblyopia (HP:0000646)1.51128382
166Redundant skin (HP:0001582)1.48875570
167Myelomeningocele (HP:0002475)1.48648907
168Abnormal number of erythroid precursors (HP:0012131)1.48456173
169Microvesicular hepatic steatosis (HP:0001414)1.47641355
170Postnatal microcephaly (HP:0005484)1.47365466

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.31543744
2PBK2.97607303
3CASK2.89032172
4PDK22.85094184
5TRIM282.78456018
6NME12.64588306
7LIMK12.53580715
8MAP3K122.49290627
9MAP4K22.45016348
10CCNB12.32673049
11ARAF2.27744234
12STK162.27164156
13OBSCN2.04826911
14WNK32.03856219
15ACVR1B2.02956338
16SRPK12.02455712
17BRAF1.93832312
18MAP2K71.89823129
19MYLK1.88913219
20SCYL21.88871733
21NUAK11.87376643
22PRPF4B1.84928521
23CDK191.84003895
24MAPK131.83763514
25VRK21.81360435
26DYRK21.80754435
27BCR1.79051111
28MARK31.78976939
29CSNK1G11.72928076
30EIF2AK11.72491469
31PLK21.69211320
32PINK11.66170505
33GRK11.65278859
34BCKDK1.63451667
35STK391.58151933
36BUB11.56554503
37VRK11.52103150
38OXSR11.47819946
39MINK11.42000730
40NEK11.41761366
41MARK11.40273595
42BMPR21.39503475
43UHMK11.37502540
44AKT31.36109200
45PLK31.35931190
46LMTK21.35563249
47ERBB31.31954999
48TLK11.27097809
49EIF2AK31.25315301
50BMPR1B1.19102171
51TESK11.17478800
52TNIK1.17275562
53MAP3K41.14529608
54TESK21.07534854
55GRK51.07205215
56INSRR1.02240775
57TSSK60.98745940
58YES10.98261374
59MKNK20.96812627
60CSNK1G30.94851070
61PIM20.93927027
62SIK30.93756115
63CAMK2D0.92237732
64CDK140.91772914
65EPHA40.90153236
66WEE10.90058492
67MKNK10.89755312
68CAMK2B0.89419154
69NEK20.88307673
70CDK180.87996033
71ROCK20.87951928
72NTRK30.87938455
73ATR0.87581990
74ADRBK10.84156107
75TTK0.83764127
76TAOK30.82591310
77NME20.82116939
78CDK80.81441857
79KSR10.80736402
80WNK40.78894903
81CAMK2A0.78853425
82ADRBK20.77330342
83FER0.75982295
84CDK150.74839372
85MAP2K40.71356352
86AURKA0.70152561
87PHKG20.69558316
88PHKG10.69558316
89MAPKAPK30.69269886
90PRKCH0.68978705
91STK38L0.68251700
92CDK11A0.67200721
93PLK10.65002459
94PAK30.63999807
95MAP3K110.63613255
96GRK70.63554888
97TIE10.63410345
98CSNK1A10.61529287
99PRKCE0.61438981
100PLK40.60924248
101KDR0.60520428
102SGK4940.60382514
103SGK2230.60382514
104BRSK20.58903946
105MATK0.57874175
106PTK2B0.57299780
107CAMK2G0.56980257
108PIK3CA0.56427665
109LATS20.56172785
110MST40.55904161
111CHEK20.55632486
112PRKCG0.54998667
113CDK30.54985958
114TAOK20.54298210
115EIF2AK20.52962845
116RPS6KA50.52694522
117CDC70.52121014
118ZAK0.50682037
119STK30.50668926
120BRSK10.50601935
121MAPKAPK50.50430960
122ATM0.49383619
123CSNK1D0.48800326
124PAK10.47761285
125PRKD30.47664255
126STK240.46239030
127MUSK0.46236013
128DYRK30.44451735
129PKN10.43655048
130NEK60.43559893
131CSNK1A1L0.43405814
132CSNK1G20.42448281
133DAPK30.41597484
134ERBB20.40521509
135CSNK2A10.40491742
136TGFBR10.40096474
137TAF10.39517274
138CDK70.39340747
139DAPK10.39120236
140PRKACA0.38572850
141PRKCI0.37590802
142PNCK0.36191194
143TXK0.36053185

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001905.40992047
2Parkinsons disease_Homo sapiens_hsa050124.76520838
3Proteasome_Homo sapiens_hsa030503.99311461
4Alzheimers disease_Homo sapiens_hsa050103.41446551
5Huntingtons disease_Homo sapiens_hsa050163.37252766
6RNA polymerase_Homo sapiens_hsa030202.89447909
7Ribosome_Homo sapiens_hsa030102.64719879
8Cardiac muscle contraction_Homo sapiens_hsa042602.59142790
9Protein export_Homo sapiens_hsa030602.49063928
10Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.45854579
11Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.15674152
12Collecting duct acid secretion_Homo sapiens_hsa049662.10744854
13Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.08351916
14Fatty acid elongation_Homo sapiens_hsa000622.05209435
15Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.69471808
16Pyrimidine metabolism_Homo sapiens_hsa002401.65745705
17Vibrio cholerae infection_Homo sapiens_hsa051101.54302030
18Nitrogen metabolism_Homo sapiens_hsa009101.53343318
19Synaptic vesicle cycle_Homo sapiens_hsa047211.46564009
20Homologous recombination_Homo sapiens_hsa034401.45578905
21Steroid biosynthesis_Homo sapiens_hsa001001.39769100
22Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.39721173
23Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.32281619
24Pyruvate metabolism_Homo sapiens_hsa006201.31062313
25Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.29736401
26DNA replication_Homo sapiens_hsa030301.27487062
27Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.25858174
28Mismatch repair_Homo sapiens_hsa034301.21448699
29Nicotine addiction_Homo sapiens_hsa050331.20583639
30Purine metabolism_Homo sapiens_hsa002301.20478194
31Spliceosome_Homo sapiens_hsa030401.18980617
32SNARE interactions in vesicular transport_Homo sapiens_hsa041301.18643514
33Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.18270640
34Selenocompound metabolism_Homo sapiens_hsa004501.17864585
35Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.12752846
36Sulfur metabolism_Homo sapiens_hsa009201.04563253
37Tryptophan metabolism_Homo sapiens_hsa003801.03517778
38Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.99749818
39RNA transport_Homo sapiens_hsa030130.99144240
40Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.98275294
41Chemical carcinogenesis_Homo sapiens_hsa052040.96632357
42Taste transduction_Homo sapiens_hsa047420.96543001
43Sulfur relay system_Homo sapiens_hsa041220.95063903
44Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.92639675
45Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.92631649
46Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.92212857
47RNA degradation_Homo sapiens_hsa030180.91706805
482-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.91682444
49Carbon metabolism_Homo sapiens_hsa012000.89718626
50Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.89200208
51Basal transcription factors_Homo sapiens_hsa030220.88580255
52Primary bile acid biosynthesis_Homo sapiens_hsa001200.88137237
53Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.87075262
54Serotonergic synapse_Homo sapiens_hsa047260.86457312
55Nucleotide excision repair_Homo sapiens_hsa034200.86372915
56Base excision repair_Homo sapiens_hsa034100.86182368
57Pentose and glucuronate interconversions_Homo sapiens_hsa000400.83216895
58Metabolic pathways_Homo sapiens_hsa011000.82828226
59Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.82571584
60Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.82219326
61Propanoate metabolism_Homo sapiens_hsa006400.81561131
62Phototransduction_Homo sapiens_hsa047440.80057246
63Olfactory transduction_Homo sapiens_hsa047400.78455030
64Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.76562985
65GABAergic synapse_Homo sapiens_hsa047270.76426501
66Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.75041687
67Fructose and mannose metabolism_Homo sapiens_hsa000510.71795513
68Folate biosynthesis_Homo sapiens_hsa007900.69866068
69Maturity onset diabetes of the young_Homo sapiens_hsa049500.69466280
70Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.69336028
71Dopaminergic synapse_Homo sapiens_hsa047280.68729471
72Glutathione metabolism_Homo sapiens_hsa004800.66710310
73Cysteine and methionine metabolism_Homo sapiens_hsa002700.66292208
74Steroid hormone biosynthesis_Homo sapiens_hsa001400.66198662
75Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.63661585
76p53 signaling pathway_Homo sapiens_hsa041150.63555132
77Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.62080542
78alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.61479509
79Ether lipid metabolism_Homo sapiens_hsa005650.60494555
80beta-Alanine metabolism_Homo sapiens_hsa004100.59904560
81Biosynthesis of amino acids_Homo sapiens_hsa012300.59721876
82Morphine addiction_Homo sapiens_hsa050320.59387502
83N-Glycan biosynthesis_Homo sapiens_hsa005100.59100586
84Fanconi anemia pathway_Homo sapiens_hsa034600.59030918
85Oocyte meiosis_Homo sapiens_hsa041140.57938686
86Circadian entrainment_Homo sapiens_hsa047130.57475188
87Retinol metabolism_Homo sapiens_hsa008300.57428651
88Drug metabolism - other enzymes_Homo sapiens_hsa009830.56431117
89Caffeine metabolism_Homo sapiens_hsa002320.54413035
90Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.54239182
91Non-homologous end-joining_Homo sapiens_hsa034500.53991062
92Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.53717498
93Arachidonic acid metabolism_Homo sapiens_hsa005900.53485211
94Phagosome_Homo sapiens_hsa041450.53289992
95Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.51863535
96Axon guidance_Homo sapiens_hsa043600.50862093
97Glutamatergic synapse_Homo sapiens_hsa047240.50749606
98Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.49296497
99Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.48909254
100Fatty acid metabolism_Homo sapiens_hsa012120.48088056
101Cell cycle_Homo sapiens_hsa041100.47085688
102Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.44313001
103Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.44273783
104Regulation of autophagy_Homo sapiens_hsa041400.42612541
105Tyrosine metabolism_Homo sapiens_hsa003500.41988027
106Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.41948788
107Glycerolipid metabolism_Homo sapiens_hsa005610.40279254
108Butanoate metabolism_Homo sapiens_hsa006500.40079694
109Fatty acid degradation_Homo sapiens_hsa000710.39512969
110Epstein-Barr virus infection_Homo sapiens_hsa051690.38938225
111Vitamin digestion and absorption_Homo sapiens_hsa049770.38063043
112Galactose metabolism_Homo sapiens_hsa000520.37104939
113Linoleic acid metabolism_Homo sapiens_hsa005910.36295469
114Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.34368837
115Rheumatoid arthritis_Homo sapiens_hsa053230.30353259
116Arginine and proline metabolism_Homo sapiens_hsa003300.30042526
117Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.29895016
118Cyanoamino acid metabolism_Homo sapiens_hsa004600.29645228
119Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.29003919
120Long-term depression_Homo sapiens_hsa047300.28938598
121Cholinergic synapse_Homo sapiens_hsa047250.28271135
122Hedgehog signaling pathway_Homo sapiens_hsa043400.26176251
123One carbon pool by folate_Homo sapiens_hsa006700.25518824
124Dilated cardiomyopathy_Homo sapiens_hsa054140.25176224
125Alcoholism_Homo sapiens_hsa050340.23361296
126Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.21802898
127Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.20766688
128Phenylalanine metabolism_Homo sapiens_hsa003600.20474112
129Calcium signaling pathway_Homo sapiens_hsa040200.20064930
130Amphetamine addiction_Homo sapiens_hsa050310.18028290
131Sphingolipid metabolism_Homo sapiens_hsa006000.17585847
132Peroxisome_Homo sapiens_hsa041460.17459568
133Long-term potentiation_Homo sapiens_hsa047200.17014501

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