TBC1D3P2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sperm capacitation (GO:0048240)8.67101358
2chromosome condensation (GO:0030261)8.55306422
3spermatid nucleus differentiation (GO:0007289)8.44623633
4single strand break repair (GO:0000012)8.25348763
5DNA packaging (GO:0006323)8.20216733
6plasma membrane fusion (GO:0045026)8.00739221
7microtubule depolymerization (GO:0007019)7.71898664
8spermatid development (GO:0007286)7.51181922
9sperm-egg recognition (GO:0035036)7.05268576
10multicellular organism reproduction (GO:0032504)6.81555665
11axonemal dynein complex assembly (GO:0070286)6.67017950
12protein polyglutamylation (GO:0018095)6.60678701
13reproduction (GO:0000003)6.40276357
14binding of sperm to zona pellucida (GO:0007339)6.35065312
15microtubule polymerization or depolymerization (GO:0031109)6.33801991
16calcium ion-dependent exocytosis (GO:0017156)6.22722571
17sexual reproduction (GO:0019953)6.16564501
18rRNA methylation (GO:0031167)6.05577600
19negative regulation of inclusion body assembly (GO:0090084)6.02779923
20cell-cell recognition (GO:0009988)5.84381063
21regulation of cilium movement (GO:0003352)5.77914144
22centriole replication (GO:0007099)5.77658545
23spermatogenesis (GO:0007283)5.73104912
24male gamete generation (GO:0048232)5.70990956
25protein targeting to Golgi (GO:0000042)5.50160529
26cellular ketone body metabolic process (GO:0046950)5.43276787
27phosphatidylethanolamine biosynthetic process (GO:0006646)5.41877633
28microtubule severing (GO:0051013)5.41808314
29establishment of protein localization to Golgi (GO:0072600)5.28087912
30gamete generation (GO:0007276)5.22970444
31antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.15417542
32centriole assembly (GO:0098534)5.12712712
33rRNA modification (GO:0000154)5.08687456
34regulation of Rab GTPase activity (GO:0032313)5.07056523
35positive regulation of Rab GTPase activity (GO:0032851)5.07056523
36retrograde transport, vesicle recycling within Golgi (GO:0000301)5.05072220
37phosphatidylethanolamine metabolic process (GO:0046337)4.95402938
38motile cilium assembly (GO:0044458)4.94027891
39cilium or flagellum-dependent cell motility (GO:0001539)4.88370896
40regulation of transcription involved in cell fate commitment (GO:0060850)4.80085836
41ketone body metabolic process (GO:1902224)4.78418691
42chromatin silencing (GO:0006342)4.64688921
43single fertilization (GO:0007338)4.59806511
44regulation of inclusion body assembly (GO:0090083)4.56314227
45epithelial cilium movement (GO:0003351)4.54536400
46germ cell development (GO:0007281)4.30839454
47protein localization to Golgi apparatus (GO:0034067)4.25679068
48regulation of centriole replication (GO:0046599)4.25315655
49multicellular organismal reproductive process (GO:0048609)4.17025061
50cilium movement (GO:0003341)4.12422237
51alanine transport (GO:0032328)4.12339526
52cellular process involved in reproduction in multicellular organism (GO:0022412)4.08511261
53regulation of microtubule-based movement (GO:0060632)4.05738915
54cell wall macromolecule metabolic process (GO:0044036)3.98528191
55cell wall macromolecule catabolic process (GO:0016998)3.95034867
56epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.87512666
57fertilization (GO:0009566)3.86413090
58nucleus organization (GO:0006997)3.75608976
59RNA destabilization (GO:0050779)3.65047258
60seminiferous tubule development (GO:0072520)3.60256048
61negative regulation of Rho protein signal transduction (GO:0035024)3.48812689
62musculoskeletal movement (GO:0050881)3.45028694
63multicellular organismal movement (GO:0050879)3.45028694
64coenzyme catabolic process (GO:0009109)3.43618101
65microtubule nucleation (GO:0007020)3.35333895
66cerebral cortex neuron differentiation (GO:0021895)3.30505341
67organic cation transport (GO:0015695)3.29490475
68cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.25594767
69glycerol ether metabolic process (GO:0006662)3.23541020
70piRNA metabolic process (GO:0034587)3.19874142
71negative regulation of gene expression, epigenetic (GO:0045814)3.17075806
72negative regulation of mesenchymal cell apoptotic process (GO:2001054)3.15977523
73peptidyl-threonine dephosphorylation (GO:0035970)3.15771758
74response to acidic pH (GO:0010447)3.15617873
75pattern specification involved in kidney development (GO:0061004)3.13602981
76polyamine biosynthetic process (GO:0006596)3.09689217
77cellular response to pH (GO:0071467)3.06071876
78ether metabolic process (GO:0018904)3.05404225
79cranial nerve morphogenesis (GO:0021602)3.01813008
80DNA methylation involved in gamete generation (GO:0043046)3.01731150
81multicellular organismal development (GO:0007275)3.00585263
82cell recognition (GO:0008037)2.98434805
83cell differentiation involved in metanephros development (GO:0072202)2.95070035
84positive regulation of skeletal muscle tissue development (GO:0048643)2.94108336
85regulation of hippo signaling (GO:0035330)2.93132420
86NAD biosynthetic process (GO:0009435)2.88085228
87nephron tubule morphogenesis (GO:0072078)2.87995790
88nephron epithelium morphogenesis (GO:0072088)2.87995790
89urinary tract smooth muscle contraction (GO:0014848)2.86945223
90mesenchymal cell differentiation involved in renal system development (GO:2001012)2.84584531
91mesenchymal cell differentiation involved in kidney development (GO:0072161)2.84584531
92regulation of somitogenesis (GO:0014807)2.84582972
93regulation of interleukin-13 production (GO:0032656)2.84098206
94detection of chemical stimulus involved in sensory perception of smell (GO:0050911)2.82800748
95mitotic G1 DNA damage checkpoint (GO:0031571)2.81398439
96spinal cord motor neuron differentiation (GO:0021522)2.80917622
97acrosome reaction (GO:0007340)11.3880098
98sperm motility (GO:0030317)11.0412913
99fusion of sperm to egg plasma membrane (GO:0007342)10.5895438
100response to pheromone (GO:0019236)10.2509235

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.58841596
2MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human3.09501904
3SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.98809334
4EZH2_22144423_ChIP-Seq_EOC_Human2.94982390
5HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.79420728
6CTBP2_25329375_ChIP-Seq_LNCAP_Human2.47092576
7POU5F1_26923725_Chip-Seq_MESODERM_Mouse2.22178267
8TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.22178267
9CTBP1_25329375_ChIP-Seq_LNCAP_Human2.21025714
10DROSHA_22980978_ChIP-Seq_HELA_Human1.99177404
11IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.94324946
12CBP_20019798_ChIP-Seq_JUKART_Human1.94324946
13ZNF274_21170338_ChIP-Seq_K562_Hela1.92294282
14EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.90460383
15ERA_21632823_ChIP-Seq_H3396_Human1.89770263
16EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.89398216
17FUS_26573619_Chip-Seq_HEK293_Human1.86793163
18RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.85636395
19UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.83530519
20NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.82382886
21CTCF_27219007_Chip-Seq_Bcells_Human1.79975047
22EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.77623324
23VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.76999935
24RAC3_21632823_ChIP-Seq_H3396_Human1.75256572
25STAT6_21828071_ChIP-Seq_BEAS2B_Human1.73789357
26ETV2_25802403_ChIP-Seq_MESCs_Mouse1.72531946
27ELF1_20517297_ChIP-Seq_JURKAT_Human1.72218774
28SUZ12_27294783_Chip-Seq_ESCs_Mouse1.70535349
29MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.70455862
30ER_23166858_ChIP-Seq_MCF-7_Human1.69535693
31NANOG_20526341_ChIP-Seq_ESCs_Human1.69095721
32TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.67926548
33TAF2_19829295_ChIP-Seq_ESCs_Human1.60153799
34BCL6_27268052_Chip-Seq_Bcells_Human1.59205883
35E2F1_20622854_ChIP-Seq_HELA_Human1.58395892
36* WDR5_24793694_ChIP-Seq_LNCAP_Human1.55853781
37EZH2_27294783_Chip-Seq_ESCs_Mouse1.54271671
38MYC_19829295_ChIP-Seq_ESCs_Human1.51686817
39AUTS2_25519132_ChIP-Seq_293T-REX_Human1.49348878
40AR_25329375_ChIP-Seq_VCAP_Human1.48556609
41CBX2_27304074_Chip-Seq_ESCs_Mouse1.47473077
42YY1_22570637_ChIP-Seq_MALME-3M_Human1.46974253
43CTCF_20526341_ChIP-Seq_ESCs_Human1.42260187
44ARNT_22903824_ChIP-Seq_MCF-7_Human1.40950742
45* SMC4_20622854_ChIP-Seq_HELA_Human1.39996359
46GATA3_21878914_ChIP-Seq_MCF-7_Human1.39430416
47* TDRD3_21172665_ChIP-Seq_MCF-7_Human1.39089008
48SMAD3_21741376_ChIP-Seq_ESCs_Human1.38913782
49SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.37785672
50SMAD4_21741376_ChIP-Seq_EPCs_Human1.36587207
51AR_21572438_ChIP-Seq_LNCaP_Human1.36525016
52EZH2_27304074_Chip-Seq_ESCs_Mouse1.36039356
53* OCT4_20526341_ChIP-Seq_ESCs_Human1.35070897
54PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.34909987
55BCOR_27268052_Chip-Seq_Bcells_Human1.30323037
56EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.30102534
57P300_19829295_ChIP-Seq_ESCs_Human1.29778742
58P68_20966046_ChIP-Seq_HELA_Human1.27514099
59* PHF8_20622854_ChIP-Seq_HELA_Human1.26558513
60ERG_20517297_ChIP-Seq_VCAP_Human1.25398816
61BMI1_23680149_ChIP-Seq_NPCS_Mouse1.25253337
62SMAD3_21741376_ChIP-Seq_EPCs_Human1.23264048
63SOX2_22085726_ChIP-Seq_NPCs_Mouse1.22135661
64P53_21459846_ChIP-Seq_SAOS-2_Human1.20798359
65P300_27268052_Chip-Seq_Bcells_Human1.20609181
66REST_21632747_ChIP-Seq_MESCs_Mouse1.20013676
67TP63_22573176_ChIP-Seq_HFKS_Human1.18795941
68RUNX2_22187159_ChIP-Seq_PCA_Human1.17869617
69TP53_18474530_ChIP-ChIP_U2OS_Human1.17578995
70SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.16528208
71TAF15_26573619_Chip-Seq_HEK293_Human1.15674097
72* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.15248520
73JARID2_20075857_ChIP-Seq_MESCs_Mouse1.14637451
74TP63_19390658_ChIP-ChIP_HaCaT_Human1.14495478
75HNFA_21074721_ChIP-Seq_CACO-2_Human1.14420344
76SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.13413807
77CBX2_22325352_ChIP-Seq_293T-Rex_Human1.12555108
78P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.12519597
79ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.11459012
80NCOR_22424771_ChIP-Seq_293T_Human1.10634619
81KLF5_20875108_ChIP-Seq_MESCs_Mouse1.09644606
82PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.09441381
83ETV1_20927104_ChIP-Seq_GIST48_Human1.09057202
84SMRT_27268052_Chip-Seq_Bcells_Human1.07601654
85RBPJ_21746931_ChIP-Seq_IB4_Human1.07451255
86LXR_22292898_ChIP-Seq_THP-1_Human1.07103211
87RUNX1_26923725_Chip-Seq_HPCs_Mouse1.07006486
88FOXH1_21741376_ChIP-Seq_ESCs_Human1.04874921
89SA1_27219007_Chip-Seq_Bcells_Human1.04389216
90ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.03775263
91NFYB_21822215_ChIP-Seq_K562_Human1.03127295
92CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.02860204
93JARID2_20064375_ChIP-Seq_MESCs_Mouse1.02636211
94VDR_22108803_ChIP-Seq_LS180_Human1.02102787
95NANOG_19829295_ChIP-Seq_ESCs_Human1.02028854
96SOX2_19829295_ChIP-Seq_ESCs_Human1.02028854
97SMAD4_21741376_ChIP-Seq_HESCs_Human1.00506109
98* CEBPB_22108803_ChIP-Seq_LS180_Human1.00342984
99FOXA1_25329375_ChIP-Seq_VCAP_Human1.00009845
100FOXA1_27270436_Chip-Seq_PROSTATE_Human1.00009845

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005377_hearing/vestibular/ear_phenot5.07551381
2MP0003878_abnormal_ear_physiology5.07551381
3MP0005670_abnormal_white_adipose4.47866077
4MP0003698_abnormal_male_reproductive4.07162513
5MP0001929_abnormal_gametogenesis3.52004177
6MP0001348_abnormal_lacrimal_gland2.98759784
7MP0000678_abnormal_parathyroid_gland2.38857684
8MP0002161_abnormal_fertility/fecundity2.26950789
9MP0003011_delayed_dark_adaptation2.25888293
10MP0003718_maternal_effect2.15964527
11MP0003136_yellow_coat_color2.03288841
12MP0005410_abnormal_fertilization10.7846680
13MP0001486_abnormal_startle_reflex1.88282148
14MP0001485_abnormal_pinna_reflex1.81781201
15MP0002249_abnormal_larynx_morphology1.80324473
16MP0005423_abnormal_somatic_nervous1.79557355
17MP0002234_abnormal_pharynx_morphology1.79311849
18MP0005379_endocrine/exocrine_gland_phen1.73686078
19MP0002210_abnormal_sex_determination1.72137472
20MP0002735_abnormal_chemical_nociception1.71887801
21MP0009053_abnormal_anal_canal1.71421181
22MP0002653_abnormal_ependyma_morphology1.69546520
23MP0002132_abnormal_respiratory_system1.65532608
24MP0001968_abnormal_touch/_nociception1.60081672
25MP0002282_abnormal_trachea_morphology1.58006137
26MP0002822_catalepsy1.49893855
27MP0004742_abnormal_vestibular_system1.45401877
28MP0000534_abnormal_ureter_morphology1.43357240
29MP0001145_abnormal_male_reproductive1.37878745
30MP0003646_muscle_fatigue1.35285961
31MP0000653_abnormal_sex_gland1.33453699
32MP0002138_abnormal_hepatobiliary_system1.29714827
33MP0004510_myositis1.26062956
34MP0008877_abnormal_DNA_methylation1.21920205
35MP0000026_abnormal_inner_ear1.17846823
36MP0006292_abnormal_olfactory_placode1.17683892
37MP0001963_abnormal_hearing_physiology1.14926945
38MP0005310_abnormal_salivary_gland1.11903597
39MP0002733_abnormal_thermal_nociception1.10845346
40MP0000049_abnormal_middle_ear1.08905949
41MP0001765_abnormal_ion_homeostasis1.06692448
42MP0000955_abnormal_spinal_cord1.05570413
43MP0009379_abnormal_foot_pigmentation1.05464304
44MP0004859_abnormal_synaptic_plasticity1.00120893
45MP0005551_abnormal_eye_electrophysiolog0.99720455
46MP0002067_abnormal_sensory_capabilities0.95361408
47MP0005248_abnormal_Harderian_gland0.90224449
48MP0000566_synostosis0.89834835
49MP0009745_abnormal_behavioral_response0.89475152
50MP0002557_abnormal_social/conspecific_i0.88879684
51MP0005395_other_phenotype0.85957629
52MP0003879_abnormal_hair_cell0.83452750
53MP0000681_abnormal_thyroid_gland0.81536258
54MP0003283_abnormal_digestive_organ0.81227417
55MP0000516_abnormal_urinary_system0.77837618
56MP0005367_renal/urinary_system_phenotyp0.77837618
57MP0002572_abnormal_emotion/affect_behav0.77750880
58MP0003137_abnormal_impulse_conducting0.76507625
59MP0002127_abnormal_cardiovascular_syste0.76482947
60MP0002229_neurodegeneration0.75670004
61MP0003880_abnormal_central_pattern0.75231519
62MP0001905_abnormal_dopamine_level0.73981007
63MP0008569_lethality_at_weaning0.73791612
64MP0000470_abnormal_stomach_morphology0.73191374
65MP0004085_abnormal_heartbeat0.72478395
66MP0001970_abnormal_pain_threshold0.72374673
67MP0005084_abnormal_gallbladder_morpholo0.71515212
68MP0001293_anophthalmia0.71307905
69MP0002272_abnormal_nervous_system0.70355346
70MP0001440_abnormal_grooming_behavior0.69743629
71MP0005253_abnormal_eye_physiology0.67569419
72MP0003119_abnormal_digestive_system0.67105424
73MP0005666_abnormal_adipose_tissue0.65524060
74MP0008995_early_reproductive_senescence0.65361875
75MP0005167_abnormal_blood-brain_barrier0.63870153
76MP0008961_abnormal_basal_metabolism0.62835202
77MP0002734_abnormal_mechanical_nocicepti0.62692232
78MP0006276_abnormal_autonomic_nervous0.62376527
79MP0005636_abnormal_mineral_homeostasis0.62271822
80MP0001879_abnormal_lymphatic_vessel0.61288002
81MP0003635_abnormal_synaptic_transmissio0.60667235
82MP0001984_abnormal_olfaction0.59791957
83MP0001666_abnormal_nutrient_absorption0.57742531
84MP0002928_abnormal_bile_duct0.57176225
85MP0002254_reproductive_system_inflammat0.54439154
86MP0000613_abnormal_salivary_gland0.53882554
87MP0003942_abnormal_urinary_system0.52387146
88MP0005535_abnormal_body_temperature0.51444326
89MP0000427_abnormal_hair_cycle0.50516009
90MP0005391_vision/eye_phenotype0.49605435
91MP0001529_abnormal_vocalization0.48338222
92MP0000372_irregular_coat_pigmentation0.48273765
93MP0005375_adipose_tissue_phenotype0.46447373
94MP0002882_abnormal_neuron_morphology0.45436390
95MP0002064_seizures0.45329016
96MP0002752_abnormal_somatic_nervous0.43419116
97MP0005195_abnormal_posterior_eye0.43381003
98MP0005647_abnormal_sex_gland0.42721315
99MP0004142_abnormal_muscle_tone0.41345664
100MP0002063_abnormal_learning/memory/cond0.41330091

Predicted human phenotypes

RankGene SetZ-score
1Severe visual impairment (HP:0001141)8.01714224
2Dynein arm defect of respiratory motile cilia (HP:0012255)5.74607666
3Absent/shortened dynein arms (HP:0200106)5.74607666
4Abnormal respiratory epithelium morphology (HP:0012253)5.34512680
5Abnormal respiratory motile cilium morphology (HP:0005938)5.34512680
6Abnormal ciliary motility (HP:0012262)5.29723860
7Abnormal respiratory motile cilium physiology (HP:0012261)4.76452896
8Attenuation of retinal blood vessels (HP:0007843)4.74236629
9Bony spicule pigmentary retinopathy (HP:0007737)4.66072001
10Asymmetric septal hypertrophy (HP:0001670)4.32923541
11Hypoplastic ischia (HP:0003175)3.99513790
12Abnormality of macular pigmentation (HP:0008002)3.98413144
13Infertility (HP:0000789)3.94468452
14Abnormal rod and cone electroretinograms (HP:0008323)3.92354964
15Bell-shaped thorax (HP:0001591)3.85652760
16Resting tremor (HP:0002322)3.82955559
17Enlarged epiphyses (HP:0010580)3.77186354
18Hyperkalemia (HP:0002153)3.73122688
19Generalized aminoaciduria (HP:0002909)3.70661679
20Chronic hepatic failure (HP:0100626)3.59812974
21Aplasia/Hypoplasia of the pubic bone (HP:0009104)3.58025082
22Facial shape deformation (HP:0011334)3.57880914
23Potter facies (HP:0002009)3.57880914
24Parkinsonism with favorable response to dopaminergic medication (HP:0002548)3.53325910
25Nasal polyposis (HP:0100582)3.50294043
26Abnormality of the ischium (HP:0003174)3.47556847
27Male infertility (HP:0003251)3.41945672
28Cone-rod dystrophy (HP:0000548)3.34146954
29Tubulointerstitial nephritis (HP:0001970)3.26834181
30Impulsivity (HP:0100710)3.24728200
31Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.20596484
32Aplasia/Hypoplasia of the earlobes (HP:0009906)3.09105319
33Nephronophthisis (HP:0000090)3.00160673
34Occipital encephalocele (HP:0002085)2.97315504
35Unilateral renal agenesis (HP:0000122)2.94466510
36Renal dysplasia (HP:0000110)2.93715530
37Abnormal spermatogenesis (HP:0008669)2.91848130
38Rhinitis (HP:0012384)2.89521381
39Azoospermia (HP:0000027)2.87693746
40Congenital malformation of the right heart (HP:0011723)2.79803878
41Double outlet right ventricle (HP:0001719)2.79803878
42Abnormality of the nasal mucosa (HP:0000433)2.70804183
43Myokymia (HP:0002411)2.62222273
44Type II lissencephaly (HP:0007260)2.50833457
45Optic nerve hypoplasia (HP:0000609)2.49916726
46Aplasia/Hypoplasia of the sacrum (HP:0008517)2.49809017
47Pancreatic fibrosis (HP:0100732)2.49341581
48Abnormality of the renal medulla (HP:0100957)2.47022683
49Amelogenesis imperfecta (HP:0000705)2.44059460
50Abnormal urine output (HP:0012590)2.42639271
51Abnormality of the pubic bones (HP:0003172)2.37317323
52Progressive cerebellar ataxia (HP:0002073)2.31714057
53Abnormality of potassium homeostasis (HP:0011042)2.29023434
54Postural instability (HP:0002172)2.28795131
55Abnormality of the aortic arch (HP:0012303)2.28753068
56Absent epiphyses (HP:0010577)2.24043231
57Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.24043231
58Hypoplasia of the thymus (HP:0000778)2.19770795
59Pendular nystagmus (HP:0012043)2.19391737
60Stage 5 chronic kidney disease (HP:0003774)2.17396601
61Bronchiectasis (HP:0002110)2.16786438
62Decreased central vision (HP:0007663)2.16225423
63Sclerocornea (HP:0000647)2.15980255
64Abnormality of the costochondral junction (HP:0000919)2.14767016
65Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.13069790
66Abnormality of dental color (HP:0011073)2.12442380
67Polydipsia (HP:0001959)2.12361790
68Abnormal drinking behavior (HP:0030082)2.12361790
69True hermaphroditism (HP:0010459)2.10734871
70Hypoplastic left heart (HP:0004383)2.10282765
71Bulbous nose (HP:0000414)2.09917846
72Abnormality of renal excretion (HP:0011036)2.08737425
73Hypoplastic heart (HP:0001961)2.03318082
74Epiphyseal dysplasia (HP:0002656)2.02876159
75Abnormality of urine glucose concentration (HP:0011016)2.01815066
76Glycosuria (HP:0003076)2.01815066
77Recurrent corneal erosions (HP:0000495)2.00620904
78Anencephaly (HP:0002323)2.00365850
79Pancreatic cysts (HP:0001737)1.98150633
80Abnormality of the parathyroid morphology (HP:0011766)1.97540369
81Esophageal atresia (HP:0002032)1.97439626
82Polyuria (HP:0000103)1.95210770
83Anterior segment dysgenesis (HP:0007700)1.94016235
84Vertebral clefting (HP:0008428)1.93411716
85Renal Fanconi syndrome (HP:0001994)1.93222434
86Abnormality of the epiphysis of the femoral head (HP:0010574)1.91265631
87Retinal dysplasia (HP:0007973)1.90950447
88Hypophosphatemic rickets (HP:0004912)1.90689607
89Osteomalacia (HP:0002749)1.86011821
90Chronic bronchitis (HP:0004469)1.84681086
91Intellectual disability, moderate (HP:0002342)1.83516903
92Portal hypertension (HP:0001409)1.83471050
93Truncal obesity (HP:0001956)1.83165072
94Congenital sensorineural hearing impairment (HP:0008527)1.82753238
95Cerebellar dysplasia (HP:0007033)1.81228186
96Abnormal ventriculo-arterial connection (HP:0011563)1.80104359
97Transposition of the great arteries (HP:0001669)1.80104359
98Abnormal connection of the cardiac segments (HP:0011545)1.80104359
99Upper limb muscle weakness (HP:0003484)1.79740551
100Respiratory distress (HP:0002098)1.79692617

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PLK47.62794624
2TESK15.38703319
3DDR25.23773490
4PNCK3.53637142
5INSRR3.39845664
6MAPK153.24963583
7MAP4K23.24705373
8STK382.79859230
9PLK22.63715349
10BRD42.31051442
11CAMK1G2.02319099
12WNK11.90267406
13WNK41.74355470
14PRKD31.60107712
15STK38L1.58238196
16PDPK11.52358435
17PDK11.41200421
18PIK3CG1.39187595
19MAP3K91.31991819
20CDK71.31434962
21DYRK1B1.28741070
22MST1R1.22191268
23UHMK11.11840714
24ZAK1.11473875
25PTK2B1.09442790
26CAMK1D1.08146418
27BMPR1B1.02173543
28KSR20.97596771
29STK390.88017726
30MUSK0.85112178
31CDK120.83881594
32LATS20.81640076
33TYRO30.80478106
34MAP2K20.80380502
35NEK60.80270003
36MAP3K110.79515855
37RPS6KA20.76549772
38SIK20.74502508
39PRKCG0.72260171
40ADRBK20.69264740
41PRKG10.68991561
42NTRK30.67489766
43BRAF0.66898591
44PRKG20.65358887
45RPS6KA10.64416810
46RPS6KA60.64059216
47MAP3K40.62528748
48MARK10.58734875
49EPHB20.58650665
50CAMK10.58535069
51DYRK30.55820801
52DYRK20.55553424
53CDK30.53057479
54CDK190.49931497
55AKT30.48372426
56PRKAA20.46509005
57GSK3B0.46300877
58RPS6KL10.46084719
59RPS6KC10.46084719
60MAPK80.45032361
61OXSR10.43765557
62TGFBR10.43653653
63WNK30.43649573
64ACVR1B0.42591425
65CDK10.42531827
66PKN10.40228821
67CDK20.40073385
68ARAF0.38150956
69FRK0.38017163
70MAP3K20.37673501
71SGK4940.37247365
72SGK2230.37247365
73CAMK40.37136675
74CDK40.37059424
75MAPK10.36601457
76PRKCZ0.35481665
77FGFR20.34589083
78MAP3K80.34199468
79ROCK10.33133073
80MAP2K70.33020425
81NEK20.32445238
82SGK10.30037378
83PASK0.29386105
84MAP3K10.27226161
85PRKACB0.26811470
86CHEK10.25915626
87TIE10.25252874
88NUAK10.24333078
89PRKACA0.23756606
90PRKCB0.23330954
91AKT10.23205692
92GRK10.21810212
93MAPK140.21747520
94IKBKB0.21583438
95AURKA0.21429861
96MAP2K40.19611806
97RIPK40.19077536
98TXK0.18692872
99STK110.17829426
100BRSK10.16353313

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000727.33028593
2Fatty acid biosynthesis_Homo sapiens_hsa000614.96858382
3Olfactory transduction_Homo sapiens_hsa047403.62906575
4Butanoate metabolism_Homo sapiens_hsa006502.66237559
5Taste transduction_Homo sapiens_hsa047422.15626863
6Dorso-ventral axis formation_Homo sapiens_hsa043201.98372446
7Cardiac muscle contraction_Homo sapiens_hsa042601.78406096
8Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.77977318
9Glycerophospholipid metabolism_Homo sapiens_hsa005641.70027744
10Nicotine addiction_Homo sapiens_hsa050331.69113093
11Morphine addiction_Homo sapiens_hsa050321.50666031
12Fatty acid degradation_Homo sapiens_hsa000711.43726660
13Phototransduction_Homo sapiens_hsa047441.41386536
14Renin-angiotensin system_Homo sapiens_hsa046141.36879999
15Hedgehog signaling pathway_Homo sapiens_hsa043401.34390707
16Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.33249499
17Selenocompound metabolism_Homo sapiens_hsa004501.32786420
18Maturity onset diabetes of the young_Homo sapiens_hsa049501.31498306
19Allograft rejection_Homo sapiens_hsa053301.31378012
20Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.30943205
21Autoimmune thyroid disease_Homo sapiens_hsa053201.29069938
22Type I diabetes mellitus_Homo sapiens_hsa049401.28558741
23Graft-versus-host disease_Homo sapiens_hsa053321.25994840
24Type II diabetes mellitus_Homo sapiens_hsa049301.25917718
25Fatty acid metabolism_Homo sapiens_hsa012121.25887500
26Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.24942384
27Antigen processing and presentation_Homo sapiens_hsa046121.24602490
28Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.21725810
29Primary bile acid biosynthesis_Homo sapiens_hsa001201.13804631
30Calcium signaling pathway_Homo sapiens_hsa040201.11651717
31Circadian entrainment_Homo sapiens_hsa047131.10664180
32Protein digestion and absorption_Homo sapiens_hsa049741.08423430
33Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.05140285
34Fat digestion and absorption_Homo sapiens_hsa049751.04065747
35RNA transport_Homo sapiens_hsa030130.98263983
36Synaptic vesicle cycle_Homo sapiens_hsa047210.97796244
37Glutamatergic synapse_Homo sapiens_hsa047240.97480601
38Arginine and proline metabolism_Homo sapiens_hsa003300.95281827
39Cocaine addiction_Homo sapiens_hsa050300.94849061
40Huntingtons disease_Homo sapiens_hsa050160.94039090
41cAMP signaling pathway_Homo sapiens_hsa040240.93653177
42Basal transcription factors_Homo sapiens_hsa030220.93105568
43Retinol metabolism_Homo sapiens_hsa008300.91552677
44Phenylalanine metabolism_Homo sapiens_hsa003600.90815119
45PPAR signaling pathway_Homo sapiens_hsa033200.90739977
46Salivary secretion_Homo sapiens_hsa049700.87866005
47alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.85596769
48Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.85522757
49Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.85121795
50Basal cell carcinoma_Homo sapiens_hsa052170.84458141
51Caffeine metabolism_Homo sapiens_hsa002320.84233384
52Ribosome_Homo sapiens_hsa030100.80622013
53Linoleic acid metabolism_Homo sapiens_hsa005910.78825356
54Adipocytokine signaling pathway_Homo sapiens_hsa049200.76641627
55ABC transporters_Homo sapiens_hsa020100.76428543
56Glycerolipid metabolism_Homo sapiens_hsa005610.75289946
57Serotonergic synapse_Homo sapiens_hsa047260.74984071
58Cholinergic synapse_Homo sapiens_hsa047250.70541777
59GABAergic synapse_Homo sapiens_hsa047270.70537145
60Alcoholism_Homo sapiens_hsa050340.69695075
61Insulin secretion_Homo sapiens_hsa049110.68984745
62Oocyte meiosis_Homo sapiens_hsa041140.68205850
63Bile secretion_Homo sapiens_hsa049760.67988807
64Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.66789136
65Amphetamine addiction_Homo sapiens_hsa050310.63870553
66Steroid hormone biosynthesis_Homo sapiens_hsa001400.62667269
67Estrogen signaling pathway_Homo sapiens_hsa049150.57840873
68Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.57080172
69Endocytosis_Homo sapiens_hsa041440.56023058
70Aldosterone synthesis and secretion_Homo sapiens_hsa049250.54401216
71Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.54203070
72Vascular smooth muscle contraction_Homo sapiens_hsa042700.53869774
73Fanconi anemia pathway_Homo sapiens_hsa034600.52332632
74Viral myocarditis_Homo sapiens_hsa054160.51676678
75Renin secretion_Homo sapiens_hsa049240.51024207
76Oxytocin signaling pathway_Homo sapiens_hsa049210.50890449
77Purine metabolism_Homo sapiens_hsa002300.50403529
78Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.50306334
79Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.49694655
80Hippo signaling pathway_Homo sapiens_hsa043900.48915158
81Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.48346153
82Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.47843867
83MAPK signaling pathway_Homo sapiens_hsa040100.44157737
84Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.44104647
85Thyroid hormone signaling pathway_Homo sapiens_hsa049190.43338569
86Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.43309016
87Gastric acid secretion_Homo sapiens_hsa049710.43179685
88Tyrosine metabolism_Homo sapiens_hsa003500.42482652
89Arginine biosynthesis_Homo sapiens_hsa002200.41483211
90Nitrogen metabolism_Homo sapiens_hsa009100.40752909
91Carbohydrate digestion and absorption_Homo sapiens_hsa049730.39740035
92Inositol phosphate metabolism_Homo sapiens_hsa005620.39693761
93Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.38361500
94Viral carcinogenesis_Homo sapiens_hsa052030.37331298
95Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.37207350
96Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.36904970
97Tryptophan metabolism_Homo sapiens_hsa003800.36603669
98Notch signaling pathway_Homo sapiens_hsa043300.30462755
99Sulfur relay system_Homo sapiens_hsa041220.29137758
100Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.25652534

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