TBC1D3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1acrosome reaction (GO:0007340)9.86259328
2fusion of sperm to egg plasma membrane (GO:0007342)9.16145326
3sperm motility (GO:0030317)9.11387372
4sperm capacitation (GO:0048240)8.19431916
5response to pheromone (GO:0019236)7.82503092
6chromosome condensation (GO:0030261)7.66148038
7DNA packaging (GO:0006323)7.35400929
8single strand break repair (GO:0000012)6.92005968
9plasma membrane fusion (GO:0045026)6.75570860
10citrulline biosynthetic process (GO:0019240)6.73095504
11sexual reproduction (GO:0019953)6.44242863
12spermatid nucleus differentiation (GO:0007289)6.21736366
13spermatid development (GO:0007286)6.13051099
14one-carbon compound transport (GO:0019755)6.10220814
15antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.97279817
16phosphatidylethanolamine biosynthetic process (GO:0006646)5.92611996
17* positive regulation of Rab GTPase activity (GO:0032851)5.47854086
18* regulation of Rab GTPase activity (GO:0032313)5.47854086
19microtubule depolymerization (GO:0007019)5.46458759
20sperm-egg recognition (GO:0035036)5.36149971
21calcium ion-dependent exocytosis (GO:0017156)5.35447864
22reproduction (GO:0000003)5.34051553
23phosphatidylethanolamine metabolic process (GO:0046337)5.32880397
24multicellular organism reproduction (GO:0032504)5.21312082
25protein targeting to Golgi (GO:0000042)4.71768652
26negative regulation of inclusion body assembly (GO:0090084)4.64492681
27binding of sperm to zona pellucida (GO:0007339)4.64409844
28spermatogenesis (GO:0007283)4.50846929
29male gamete generation (GO:0048232)4.48933181
30citrulline metabolic process (GO:0000052)4.48678588
31retrograde transport, vesicle recycling within Golgi (GO:0000301)4.45422660
32chromatin silencing (GO:0006342)4.44278164
33establishment of protein localization to Golgi (GO:0072600)4.43726191
34axonemal dynein complex assembly (GO:0070286)4.43503178
35microtubule polymerization or depolymerization (GO:0031109)4.40457525
36cell-cell recognition (GO:0009988)4.38890264
37negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)4.34725922
38microtubule severing (GO:0051013)4.34716712
39rRNA methylation (GO:0031167)4.32956025
40regulation of transcription involved in cell fate commitment (GO:0060850)4.31305813
41protein polyglutamylation (GO:0018095)4.27751929
42regulation of T-helper 2 cell differentiation (GO:0045628)4.27743437
43motile cilium assembly (GO:0044458)4.20696432
44centriole replication (GO:0007099)4.13865377
45peptidyl-arginine modification (GO:0018195)4.12494216
46gas transport (GO:0015669)4.09180420
47gamete generation (GO:0007276)4.04030068
48cell wall macromolecule metabolic process (GO:0044036)3.88633579
49regulation of cilium movement (GO:0003352)3.88277488
50centriole assembly (GO:0098534)3.76324124
51RNA destabilization (GO:0050779)3.73488705
52cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.69844007
53cell wall macromolecule catabolic process (GO:0016998)3.69366846
54regulation of interleukin-13 production (GO:0032656)3.68941389
55regulation of ARF GTPase activity (GO:0032312)3.59016396
56germ cell development (GO:0007281)3.54956314
57response to acidic pH (GO:0010447)3.53067522
58cellular process involved in reproduction in multicellular organism (GO:0022412)3.48254245
59protein-DNA complex disassembly (GO:0032986)3.46911404
60nucleosome disassembly (GO:0006337)3.46911404
61single fertilization (GO:0007338)3.45244711
62protein localization to Golgi apparatus (GO:0034067)3.42322993
63cerebral cortex neuron differentiation (GO:0021895)3.41896343
64camera-type eye morphogenesis (GO:0048593)3.36804235
65rRNA modification (GO:0000154)3.35662743
66peptide catabolic process (GO:0043171)3.34544547
67regulation of histone H3-K27 methylation (GO:0061085)3.30950674
68regulation of inclusion body assembly (GO:0090083)3.30295366
69multicellular organismal reproductive process (GO:0048609)3.28634966
70cell-cell junction maintenance (GO:0045217)3.28322388
71cilium or flagellum-dependent cell motility (GO:0001539)3.25300203
72cellular ketone body metabolic process (GO:0046950)3.22497697
73negative regulation of gene expression, epigenetic (GO:0045814)3.21632081
74negative regulation of granulocyte differentiation (GO:0030853)3.19738784
75nucleus organization (GO:0006997)3.19618516
76histone H3-K9 demethylation (GO:0033169)3.19573596
77apoptotic cell clearance (GO:0043277)3.17577176
78cranial nerve morphogenesis (GO:0021602)3.16350702
79face development (GO:0060324)3.13540314
80branching involved in salivary gland morphogenesis (GO:0060445)3.12960465
81positive regulation of type 2 immune response (GO:0002830)3.12584562
82positive regulation of histone deacetylation (GO:0031065)3.11749262
83histone H4 deacetylation (GO:0070933)3.10879363
84negative regulation of mesenchymal cell apoptotic process (GO:2001054)3.07889792
85organic cation transport (GO:0015695)3.06626861
86cellular response to pH (GO:0071467)3.05540308
87homeostasis of number of cells within a tissue (GO:0048873)3.02754741
88negative regulation of Rho protein signal transduction (GO:0035024)2.98488776
89negative regulation of histone methylation (GO:0031061)2.96836334
90fertilization (GO:0009566)2.86290401
91regulation of centriole replication (GO:0046599)2.86054852
92peptidyl-threonine dephosphorylation (GO:0035970)2.82549354
93regulation of microtubule-based movement (GO:0060632)2.81803674
94seminiferous tubule development (GO:0072520)2.80325400
95insulin-like growth factor receptor signaling pathway (GO:0048009)2.74817603
96membrane protein intracellular domain proteolysis (GO:0031293)2.73209109
97ketone body metabolic process (GO:1902224)2.72696559
98regulation of interleukin-5 production (GO:0032674)2.69752204
99regulation of apoptotic process involved in morphogenesis (GO:1902337)2.69095238
100polyamine biosynthetic process (GO:0006596)2.68085287

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat8.28126279
2MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.87313481
3LXR_22292898_ChIP-Seq_THP-1_Human2.84348153
4ELF1_20517297_ChIP-Seq_JURKAT_Human2.36699072
5THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.32341053
6RARG_19884340_ChIP-ChIP_MEFs_Mouse2.18013666
7SMC4_20622854_ChIP-Seq_HELA_Human2.17594061
8BCL6_27268052_Chip-Seq_Bcells_Human2.09132041
9P68_20966046_ChIP-Seq_HELA_Human2.07202985
10CTCF_27219007_Chip-Seq_Bcells_Human2.06503755
11BCOR_27268052_Chip-Seq_Bcells_Human2.02327378
12GATA1_19941826_ChIP-Seq_K562_Human1.96193353
13STAT6_21828071_ChIP-Seq_BEAS2B_Human1.85885334
14SA1_27219007_Chip-Seq_ERYTHROID_Human1.81913320
15E2F1_20622854_ChIP-Seq_HELA_Human1.78845217
16RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.77965897
17KDM2B_26808549_Chip-Seq_SUP-B15_Human1.76682031
18SA1_27219007_Chip-Seq_Bcells_Human1.76435510
19PHF8_20622854_ChIP-Seq_HELA_Human1.76342617
20EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.75550161
21ELK3_25401928_ChIP-Seq_HUVEC_Human1.73069895
22VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.71063229
23KDM2B_26808549_Chip-Seq_DND41_Human1.69351967
24TP63_22573176_ChIP-Seq_HFKS_Human1.66183539
25SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.63969775
26YY1_22570637_ChIP-Seq_MALME-3M_Human1.54284067
27TCF7_22412390_ChIP-Seq_EML_Mouse1.54114819
28KDM2B_26808549_Chip-Seq_K562_Human1.51823953
29RACK7_27058665_Chip-Seq_MCF-7_Human1.50663312
30EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.50618503
31CTCF_20526341_ChIP-Seq_ESCs_Human1.49995531
32KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.49779109
33CTCF_27219007_Chip-Seq_ERYTHROID_Human1.49731316
34BP1_19119308_ChIP-ChIP_Hs578T_Human1.47993457
35EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.45760852
36RAC3_21632823_ChIP-Seq_H3396_Human1.44953465
37ERA_21632823_ChIP-Seq_H3396_Human1.42867148
38E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.42644100
39UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.39752139
40RUNX1_27514584_Chip-Seq_MCF-7_Human1.39659550
41P300_27268052_Chip-Seq_Bcells_Human1.36480125
42KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.35708704
43MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.35542115
44SPI1_23127762_ChIP-Seq_K562_Human1.35465620
45NANOG_20526341_ChIP-Seq_ESCs_Human1.35115172
46DROSHA_22980978_ChIP-Seq_HELA_Human1.33978427
47SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.33378235
48P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.32245208
49TET1_21451524_ChIP-Seq_MESCs_Mouse1.30967860
50KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.30864179
51PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.28932440
52KLF5_25053715_ChIP-Seq_YYC3_Human1.28874279
53TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.28204169
54NFIB_24661679_ChIP-Seq_LUNG_Mouse1.26032455
55TP53_22127205_ChIP-Seq_IMR90_Human1.25276826
56MAF_26560356_Chip-Seq_TH2_Human1.24854532
57SCL_19346495_ChIP-Seq_HPC-7_Human1.24787815
58P63_26484246_Chip-Seq_KERATINOCYTES_Human1.24137887
59KDM2B_26808549_Chip-Seq_JURKAT_Human1.23792015
60NCOR1_26117541_ChIP-Seq_K562_Human1.21155652
61EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.20005648
62TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.19482064
63FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.18889480
64CTCF_21964334_Chip-Seq_Bcells_Human1.16770327
65MAF_26560356_Chip-Seq_TH1_Human1.16194673
66SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.13967908
67KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.13719655
68TAF2_19829295_ChIP-Seq_ESCs_Human1.13243870
69GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.12981082
70OCT4_19829295_ChIP-Seq_ESCs_Human1.07455050
71RARA_24833708_ChIP-Seq_LIVER_Mouse1.07331463
72TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.06883059
73SUZ12_27294783_Chip-Seq_ESCs_Mouse1.06626590
74OCT4_20526341_ChIP-Seq_ESCs_Human1.06165997
75KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.06067482
76GATA2_19941826_ChIP-Seq_K562_Human1.04958357
77CREB1_26743006_Chip-Seq_LNCaP_Human1.04777990
78VDR_21846776_ChIP-Seq_THP-1_Human1.04398293
79WDR5_24793694_ChIP-Seq_LNCAP_Human1.03388355
80ZFP281_18757296_ChIP-ChIP_E14_Mouse1.03110847
81HIF1A_21447827_ChIP-Seq_MCF-7_Human1.01022152
82SPI1_20517297_ChIP-Seq_HL60_Human1.00281299
83CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.99640000
84GATA1_19941827_ChIP-Seq_MEL_Mouse0.98993174
85DNAJC2_21179169_ChIP-ChIP_NT2_Human0.97586825
86PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.97019615
87VDR_24763502_ChIP-Seq_THP-1_Human0.96829700
88POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.96454458
89TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96454458
90RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.95334360
91SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.95108221
92ATF3_27146783_Chip-Seq_COLON_Human0.95096758
93P300_27058665_Chip-Seq_ZR-75-30cells_Human0.94541980
94JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.94152946
95SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.93981968
96CSB_26484114_Chip-Seq_FIBROBLAST_Human0.93275312
97UBF1/2_26484160_Chip-Seq_HMECs_Human0.93242324
98MYC_19829295_ChIP-Seq_ESCs_Human0.93147312
99RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.91932482
100TET1_21490601_ChIP-Seq_MESCs_Mouse0.91541847

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization9.39626415
2MP0005377_hearing/vestibular/ear_phenot5.48948284
3MP0003878_abnormal_ear_physiology5.48948284
4MP0005670_abnormal_white_adipose4.22888711
5MP0001348_abnormal_lacrimal_gland4.13306325
6MP0003698_abnormal_male_reproductive3.12674826
7MP0000678_abnormal_parathyroid_gland3.12468812
8MP0005451_abnormal_body_composition2.74527158
9MP0002132_abnormal_respiratory_system2.66102010
10MP0004510_myositis2.65409882
11MP0001929_abnormal_gametogenesis2.60874822
12MP0002138_abnormal_hepatobiliary_system2.60248484
13MP0003436_decreased_susceptibility_to2.26848556
14MP0005083_abnormal_biliary_tract2.17998556
15MP0009053_abnormal_anal_canal1.91360129
16MP0002161_abnormal_fertility/fecundity1.78539045
17MP0002249_abnormal_larynx_morphology1.54916317
18MP0002282_abnormal_trachea_morphology1.53821264
19MP0009764_decreased_sensitivity_to1.50899173
20MP0003172_abnormal_lysosome_physiology1.40422579
21MP0000534_abnormal_ureter_morphology1.36155203
22MP0005248_abnormal_Harderian_gland1.33943542
23MP0003303_peritoneal_inflammation1.32226839
24MP0001873_stomach_inflammation1.31254898
25MP0003300_gastrointestinal_ulcer1.21597708
26MP0005666_abnormal_adipose_tissue1.20197042
27MP0002210_abnormal_sex_determination1.19863024
28MP0009278_abnormal_bone_marrow1.18662878
29MP0000685_abnormal_immune_system1.14639647
30MP0003566_abnormal_cell_adhesion1.11339747
31MP0001849_ear_inflammation1.10376484
32MP0004947_skin_inflammation1.09331357
33MP0005310_abnormal_salivary_gland1.09329565
34MP0002822_catalepsy1.06492699
35MP0001533_abnormal_skeleton_physiology1.06433517
36MP0002419_abnormal_innate_immunity1.06126260
37MP0005164_abnormal_response_to1.00324407
38MP0004264_abnormal_extraembryonic_tissu0.99136421
39MP0003656_abnormal_erythrocyte_physiolo0.96039885
40MP0002933_joint_inflammation0.92825662
41MP0003448_altered_tumor_morphology0.92625206
42MP0001765_abnormal_ion_homeostasis0.92546177
43MP0004859_abnormal_synaptic_plasticity0.90566717
44MP0003329_amyloid_beta_deposits0.89110099
45MP0005375_adipose_tissue_phenotype0.88645370
46MP0000681_abnormal_thyroid_gland0.88193577
47MP0003091_abnormal_cell_migration0.86011696
48MP0003453_abnormal_keratinocyte_physiol0.85435187
49MP0005166_decreased_susceptibility_to0.84357315
50MP0001145_abnormal_male_reproductive0.83528376
51MP0005025_abnormal_response_to0.82605814
52MP0009785_altered_susceptibility_to0.81576809
53MP0002998_abnormal_bone_remodeling0.81519200
54MP0000343_altered_response_to0.80826502
55MP0000858_altered_metastatic_potential0.80342669
56MP0002653_abnormal_ependyma_morphology0.79216921
57MP0002139_abnormal_hepatobiliary_system0.78606769
58MP0005379_endocrine/exocrine_gland_phen0.78408757
59MP0000653_abnormal_sex_gland0.76073715
60MP0001545_abnormal_hematopoietic_system0.75036209
61MP0005397_hematopoietic_system_phenotyp0.75036209
62MP0000249_abnormal_blood_vessel0.73789928
63MP0005167_abnormal_blood-brain_barrier0.69270992
64MP0003879_abnormal_hair_cell0.69058620
65MP0005390_skeleton_phenotype0.68844336
66MP0005623_abnormal_meninges_morphology0.68344253
67MP0002127_abnormal_cardiovascular_syste0.67099054
68MP0000566_synostosis0.66951291
69MP0003646_muscle_fatigue0.63926750
70MP0000049_abnormal_middle_ear0.63580860
71MP0004742_abnormal_vestibular_system0.63170933
72MP0005076_abnormal_cell_differentiation0.63024545
73MP0005023_abnormal_wound_healing0.62341562
74MP0008004_abnormal_stomach_pH0.60599052
75MP0002452_abnormal_antigen_presenting0.58826406
76MP0009115_abnormal_fat_cell0.58451034
77MP0004883_abnormal_blood_vessel0.57737859
78MP0000613_abnormal_salivary_gland0.57606371
79MP0003011_delayed_dark_adaptation0.57272401
80MP0000733_abnormal_muscle_development0.56549799
81MP0000955_abnormal_spinal_cord0.56060893
82MP0009840_abnormal_foam_cell0.56023368
83MP0003718_maternal_effect0.55845678
84MP0004085_abnormal_heartbeat0.55808899
85MP0002723_abnormal_immune_serum0.54208177
86MP0005647_abnormal_sex_gland0.53442871
87MP0001790_abnormal_immune_system0.52554496
88MP0005387_immune_system_phenotype0.52554496
89MP0004084_abnormal_cardiac_muscle0.52552244
90MP0002733_abnormal_thermal_nociception0.50877607
91MP0005595_abnormal_vascular_smooth0.50538871
92MP0000026_abnormal_inner_ear0.50237145
93MP0001963_abnormal_hearing_physiology0.49174224
94MP0001905_abnormal_dopamine_level0.48842197
95MP0008469_abnormal_protein_level0.48739870
96MP0000470_abnormal_stomach_morphology0.46812737
97MP0005423_abnormal_somatic_nervous0.46543429
98MP0005636_abnormal_mineral_homeostasis0.46079316
99MP0001486_abnormal_startle_reflex0.43735588
100MP0004484_altered_response_of0.43557329

Predicted human phenotypes

RankGene SetZ-score
1Severe visual impairment (HP:0001141)7.46606371
2Asymmetric septal hypertrophy (HP:0001670)5.62687367
3Parkinsonism with favorable response to dopaminergic medication (HP:0002548)5.24401702
4Focal segmental glomerulosclerosis (HP:0000097)4.32267678
5Bell-shaped thorax (HP:0001591)4.04352317
6Dynein arm defect of respiratory motile cilia (HP:0012255)3.82781208
7Absent/shortened dynein arms (HP:0200106)3.82781208
8Nasal polyposis (HP:0100582)3.82093724
9Bony spicule pigmentary retinopathy (HP:0007737)3.61592946
10Hyperkalemia (HP:0002153)3.53757237
11Male infertility (HP:0003251)3.41966621
12Glomerulosclerosis (HP:0000096)3.40322068
13Upper limb amyotrophy (HP:0009129)3.39023363
14Distal upper limb amyotrophy (HP:0007149)3.39023363
15Hypochromic microcytic anemia (HP:0004840)3.37581173
16Potter facies (HP:0002009)3.34771637
17Facial shape deformation (HP:0011334)3.34771637
18Hypoplastic ischia (HP:0003175)3.29017464
19Tubulointerstitial nephritis (HP:0001970)3.28959758
20Cone-rod dystrophy (HP:0000548)3.23994063
21Abnormality of the nasal mucosa (HP:0000433)3.13379273
22Infertility (HP:0000789)3.11275812
23Resting tremor (HP:0002322)3.09729541
24Aplasia/Hypoplasia of the earlobes (HP:0009906)2.96910004
25Attenuation of retinal blood vessels (HP:0007843)2.96419515
26Abnormality of macular pigmentation (HP:0008002)2.86669273
27Enlarged epiphyses (HP:0010580)2.85436611
28Stage 5 chronic kidney disease (HP:0003774)2.83417618
29Abnormality of the ischium (HP:0003174)2.82967806
30Easy fatigability (HP:0003388)2.81817503
31Distal lower limb amyotrophy (HP:0008944)2.81184370
32Arterial tortuosity (HP:0005116)2.76950350
33Unilateral renal agenesis (HP:0000122)2.74294429
34Aplasia/Hypoplasia of the sacrum (HP:0008517)2.73500251
35Impulsivity (HP:0100710)2.71579160
36Abnormal rod and cone electroretinograms (HP:0008323)2.70562678
37Axonal loss (HP:0003447)2.65730338
38Abnormal ciliary motility (HP:0012262)2.49975818
39Abnormal respiratory motile cilium physiology (HP:0012261)2.45911088
40Abnormal respiratory epithelium morphology (HP:0012253)2.44948155
41Abnormal respiratory motile cilium morphology (HP:0005938)2.44948155
42Hypoplasia of the thymus (HP:0000778)2.43913860
43Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.43078021
44Abnormality of the aortic arch (HP:0012303)2.42283952
45Gastrointestinal infarctions (HP:0005244)2.41981717
46Glucose intolerance (HP:0000833)2.37151629
47Vascular tortuosity (HP:0004948)2.36047803
48Flattened epiphyses (HP:0003071)2.35070792
49Postural instability (HP:0002172)2.32951524
50Abnormal spermatogenesis (HP:0008669)2.32192835
51Reticulocytosis (HP:0001923)2.26347490
52Ectopia lentis (HP:0001083)2.23880643
53Ventricular tachycardia (HP:0004756)2.22469769
54Gingivitis (HP:0000230)2.21627819
55Abnormality of macrophages (HP:0004311)2.18549523
56Spondylolisthesis (HP:0003302)2.16957252
57Atrophic scars (HP:0001075)2.16387193
58Epiphyseal dysplasia (HP:0002656)2.15485979
59Atelectasis (HP:0100750)2.12116025
60Bowel incontinence (HP:0002607)2.10919296
61Azoospermia (HP:0000027)2.10348837
62Progressive sensorineural hearing impairment (HP:0000408)2.07884426
63Tubular atrophy (HP:0000092)2.02856020
64Hypochromic anemia (HP:0001931)2.02179211
65Protuberant abdomen (HP:0001538)2.01112277
66Increased purine levels (HP:0004368)1.99579153
67Hyperuricemia (HP:0002149)1.99579153
68Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.98756737
69Absent epiphyses (HP:0010577)1.98756737
70Hyperthyroidism (HP:0000836)1.97781931
71Hyponatremia (HP:0002902)1.96752057
72Vertebral clefting (HP:0008428)1.93028438
73Abnormality of the costochondral junction (HP:0000919)1.92951360
74Subcapsular cataract (HP:0000523)1.92570447
75Abnormal large intestine physiology (HP:0012700)1.91708594
76Abnormal urine output (HP:0012590)1.88841641
77Recurrent pneumonia (HP:0006532)1.87305433
78Abnormality of the heme biosynthetic pathway (HP:0010472)1.85790106
79Thin bony cortex (HP:0002753)1.84598244
80Abnormality of dental color (HP:0011073)1.84451176
81Broad face (HP:0000283)1.83433322
82Poikilocytosis (HP:0004447)1.82253340
83Abnormality of renal excretion (HP:0011036)1.80847405
84Amelogenesis imperfecta (HP:0000705)1.78490812
85Prolonged neonatal jaundice (HP:0006579)1.78046753
86Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.77599574
87Hand muscle atrophy (HP:0009130)1.76553372
88Spastic paraparesis (HP:0002313)1.75908361
89Truncus arteriosus (HP:0001660)1.75710722
90Renal dysplasia (HP:0000110)1.74587544
91Peritonitis (HP:0002586)1.74502162
92Slow saccadic eye movements (HP:0000514)1.73110017
93Widely patent fontanelles and sutures (HP:0004492)1.70645493
94Chronic obstructive pulmonary disease (HP:0006510)1.69109510
95Obstructive lung disease (HP:0006536)1.69109510
96Cellulitis (HP:0100658)1.68791691
97Polar cataract (HP:0010696)1.68540786
98Aplasia/Hypoplasia of the thymus (HP:0010515)1.67164371
99Abnormality of chloride homeostasis (HP:0011422)1.66959967
100Abnormality involving the epiphyses of the lower limbs (HP:0006500)1.65989090

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PLK44.97938398
2TESK14.74693128
3MST1R4.69955684
4EPHA24.69293591
5DDR24.47845326
6SIK12.67867196
7STK382.52815310
8LMTK22.29691072
9TESK22.29400713
10ERN12.05681810
11MAP3K91.90672839
12SIK21.72572818
13MAPK151.69642111
14PDPK11.58647037
15MET1.57700788
16ICK1.46009886
17CAMK1G1.43187721
18INSRR1.34412470
19MARK21.31674986
20MAP3K71.29611157
21PDK11.28718512
22STK161.28204602
23MAP3K111.27577475
24TRIB31.23296627
25PLK21.20671425
26NTRK11.19181016
27PTK2B1.18900429
28PTK61.17502247
29RIPK41.15516730
30MAP4K11.12165317
31WNK11.11699568
32IRAK31.11210046
33RPS6KA21.08261982
34CDK71.05649741
35DYRK1B1.02248234
36PRKG21.01678618
37BMX1.01004083
38EPHB10.95117351
39TNK20.94367219
40RPS6KC10.93378119
41RPS6KL10.93378119
42CAMK1D0.91769262
43BRD40.90719368
44EPHB20.90182203
45JAK30.86248177
46MAP3K20.85445751
47KSR20.84178380
48PNCK0.83435265
49MAP3K130.78316441
50RPS6KA60.78114760
51CDK80.76998422
52MAP3K30.76211861
53MTOR0.75739578
54PRKD30.75333042
55MAP3K10.73561001
56BRAF0.71000219
57MAP3K80.70864528
58CDK120.69849592
59RPS6KA10.68540693
60PTK20.67710573
61TAOK10.62313483
62ARAF0.61253139
63MARK30.58991731
64ZAP700.58565574
65MAP4K20.57164077
66IKBKB0.56711683
67CHUK0.56094519
68MUSK0.53713280
69CSK0.51388609
70PIK3CG0.47594997
71PDGFRA0.47511639
72PRKCZ0.45324507
73FGFR40.45241156
74HIPK20.44988410
75TYRO30.43222635
76ROCK10.43116383
77CDK40.42784135
78MAPK80.42269637
79BTK0.42228895
80CDC42BPA0.41706930
81NEK60.41687376
82MAP2K20.40631862
83PRKAA20.40039340
84PKN20.39630748
85BLK0.39146171
86RIPK10.39025249
87MAPK10.38968624
88CAMK10.38890902
89MAP2K30.38321935
90LATS20.36235819
91PRKG10.35189681
92TBK10.34683997
93GRK60.34191227
94PRPF4B0.33268340
95ROCK20.32251651
96MATK0.30485704
97NME20.29727822
98IRAK40.29435738
99CSF1R0.29349843
100GSK3B0.26893982

Predicted pathways (KEGG)

RankGene SetZ-score
1Butirosin and neomycin biosynthesis_Homo sapiens_hsa005244.43146566
2Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.64238775
3Fatty acid biosynthesis_Homo sapiens_hsa000613.57095099
4Notch signaling pathway_Homo sapiens_hsa043302.11286061
5Olfactory transduction_Homo sapiens_hsa047401.96313419
6Acute myeloid leukemia_Homo sapiens_hsa052211.93510883
7Allograft rejection_Homo sapiens_hsa053301.88321697
8Glycerophospholipid metabolism_Homo sapiens_hsa005641.84692323
9Graft-versus-host disease_Homo sapiens_hsa053321.75559090
10Autoimmune thyroid disease_Homo sapiens_hsa053201.70570033
11Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.66456696
12Adipocytokine signaling pathway_Homo sapiens_hsa049201.56955878
13Endocytosis_Homo sapiens_hsa041441.56265041
14Type II diabetes mellitus_Homo sapiens_hsa049301.52656722
15Osteoclast differentiation_Homo sapiens_hsa043801.46083316
16Type I diabetes mellitus_Homo sapiens_hsa049401.39484184
17Influenza A_Homo sapiens_hsa051641.37773586
18Dorso-ventral axis formation_Homo sapiens_hsa043201.31240932
19African trypanosomiasis_Homo sapiens_hsa051431.30988847
20VEGF signaling pathway_Homo sapiens_hsa043701.28861860
21Malaria_Homo sapiens_hsa051441.28579508
22Antigen processing and presentation_Homo sapiens_hsa046121.27791273
23AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.26113893
24Leishmaniasis_Homo sapiens_hsa051401.22046189
25Viral myocarditis_Homo sapiens_hsa054161.21024554
26Chronic myeloid leukemia_Homo sapiens_hsa052201.16833592
27Inositol phosphate metabolism_Homo sapiens_hsa005621.16062942
28B cell receptor signaling pathway_Homo sapiens_hsa046621.15226903
29Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.14885533
30Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.13352535
31Toxoplasmosis_Homo sapiens_hsa051451.13274937
32Thyroid hormone signaling pathway_Homo sapiens_hsa049191.06419428
33NF-kappa B signaling pathway_Homo sapiens_hsa040641.03800080
34Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.97985158
35Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.95875805
36Other glycan degradation_Homo sapiens_hsa005110.94307740
37Glycosaminoglycan degradation_Homo sapiens_hsa005310.93890476
38Pancreatic cancer_Homo sapiens_hsa052120.93575900
39Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.93311738
40Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.91881626
41Jak-STAT signaling pathway_Homo sapiens_hsa046300.90751358
42Carbohydrate digestion and absorption_Homo sapiens_hsa049730.89986508
43TNF signaling pathway_Homo sapiens_hsa046680.86630481
44Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.85102834
45ECM-receptor interaction_Homo sapiens_hsa045120.83320320
46Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.82111753
47Salivary secretion_Homo sapiens_hsa049700.78477303
48Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.78222783
49Galactose metabolism_Homo sapiens_hsa000520.76737301
50RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.76118675
51Chemokine signaling pathway_Homo sapiens_hsa040620.76115754
52Prolactin signaling pathway_Homo sapiens_hsa049170.75817336
53Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.74836670
54mTOR signaling pathway_Homo sapiens_hsa041500.74747736
55Protein digestion and absorption_Homo sapiens_hsa049740.73852551
56Renal cell carcinoma_Homo sapiens_hsa052110.73723531
57Synaptic vesicle cycle_Homo sapiens_hsa047210.72423541
58MAPK signaling pathway_Homo sapiens_hsa040100.72178282
59Phosphatidylinositol signaling system_Homo sapiens_hsa040700.70226653
60Leukocyte transendothelial migration_Homo sapiens_hsa046700.70027748
61Insulin resistance_Homo sapiens_hsa049310.69860895
62Phospholipase D signaling pathway_Homo sapiens_hsa040720.69856104
63Insulin signaling pathway_Homo sapiens_hsa049100.66224063
64Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.66031754
65Bladder cancer_Homo sapiens_hsa052190.65791832
66Transcriptional misregulation in cancer_Homo sapiens_hsa052020.65642331
67Herpes simplex infection_Homo sapiens_hsa051680.64850145
68Choline metabolism in cancer_Homo sapiens_hsa052310.63939959
69Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.63493140
70Adherens junction_Homo sapiens_hsa045200.62651491
71Non-small cell lung cancer_Homo sapiens_hsa052230.61378861
72HIF-1 signaling pathway_Homo sapiens_hsa040660.61031817
73Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.60347912
74Estrogen signaling pathway_Homo sapiens_hsa049150.59562124
75Tuberculosis_Homo sapiens_hsa051520.57965253
76Focal adhesion_Homo sapiens_hsa045100.57189782
77Toll-like receptor signaling pathway_Homo sapiens_hsa046200.55836023
78Phenylalanine metabolism_Homo sapiens_hsa003600.55642046
79Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.54844954
80Fructose and mannose metabolism_Homo sapiens_hsa000510.54112207
81Regulation of actin cytoskeleton_Homo sapiens_hsa048100.54102486
82Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.53939232
83T cell receptor signaling pathway_Homo sapiens_hsa046600.53814954
84Measles_Homo sapiens_hsa051620.53690996
85Viral carcinogenesis_Homo sapiens_hsa052030.52718482
86Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.52496113
87Amoebiasis_Homo sapiens_hsa051460.52260511
88Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.50260151
89Tight junction_Homo sapiens_hsa045300.50102785
90Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.49074957
91FoxO signaling pathway_Homo sapiens_hsa040680.48527293
92NOD-like receptor signaling pathway_Homo sapiens_hsa046210.46899343
93Central carbon metabolism in cancer_Homo sapiens_hsa052300.46863271
94ABC transporters_Homo sapiens_hsa020100.45440279
95MicroRNAs in cancer_Homo sapiens_hsa052060.44825865
96ErbB signaling pathway_Homo sapiens_hsa040120.44241917
97PPAR signaling pathway_Homo sapiens_hsa033200.43501962
98Hepatitis B_Homo sapiens_hsa051610.41305164
99Legionellosis_Homo sapiens_hsa051340.40305554
100HTLV-I infection_Homo sapiens_hsa051660.39692203

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