TBC1D29

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1response to pheromone (GO:0019236)9.54510513
2sperm capacitation (GO:0048240)7.80149223
3plasma membrane fusion (GO:0045026)7.61941564
4chromosome condensation (GO:0030261)6.93866795
5spermatid development (GO:0007286)6.77871698
6DNA packaging (GO:0006323)6.75333153
7multicellular organism reproduction (GO:0032504)6.69487273
8single strand break repair (GO:0000012)6.43300945
9microtubule depolymerization (GO:0007019)6.42825970
10spermatid nucleus differentiation (GO:0007289)6.35964390
11cilium or flagellum-dependent cell motility (GO:0001539)6.29298012
12sperm-egg recognition (GO:0035036)6.21549444
13protein polyglutamylation (GO:0018095)6.09231425
14reproduction (GO:0000003)5.98955806
15establishment of protein localization to Golgi (GO:0072600)5.95207887
16microtubule polymerization or depolymerization (GO:0031109)5.90224088
17calcium ion-dependent exocytosis (GO:0017156)5.88842692
18protein targeting to Golgi (GO:0000042)5.67639090
19phosphatidylethanolamine biosynthetic process (GO:0006646)5.61892948
20axonemal dynein complex assembly (GO:0070286)5.50442134
21cellular ketone body metabolic process (GO:0046950)5.40019605
22retrograde transport, vesicle recycling within Golgi (GO:0000301)5.30279938
23centriole replication (GO:0007099)5.26736894
24negative regulation of inclusion body assembly (GO:0090084)5.24145402
25* positive regulation of Rab GTPase activity (GO:0032851)5.21294578
26* regulation of Rab GTPase activity (GO:0032313)5.21294578
27cell-cell recognition (GO:0009988)5.19432593
28phosphatidylethanolamine metabolic process (GO:0046337)5.13528578
29spermatogenesis (GO:0007283)5.08237678
30binding of sperm to zona pellucida (GO:0007339)5.07037444
31male gamete generation (GO:0048232)5.06691977
32sexual reproduction (GO:0019953)4.97904986
33motile cilium assembly (GO:0044458)4.96133352
34rRNA methylation (GO:0031167)4.92831406
35microtubule severing (GO:0051013)4.92481873
36ketone body metabolic process (GO:1902224)4.72003080
37musculoskeletal movement (GO:0050881)4.68257616
38multicellular organismal movement (GO:0050879)4.68257616
39regulation of transcription involved in cell fate commitment (GO:0060850)4.66651400
40gamete generation (GO:0007276)4.61251774
41centriole assembly (GO:0098534)4.58225395
42single fertilization (GO:0007338)4.24671874
43regulation of cilium movement (GO:0003352)4.17878918
44cell wall macromolecule metabolic process (GO:0044036)4.12388475
45protein localization to Golgi apparatus (GO:0034067)4.00059898
46NAD biosynthetic process (GO:0009435)3.89987134
47epithelial cilium movement (GO:0003351)3.88962300
48antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.79072831
49germ cell development (GO:0007281)3.77918787
50cilium movement (GO:0003341)3.75667528
51rRNA modification (GO:0000154)3.74453531
52negative regulation of Rho protein signal transduction (GO:0035024)3.70854544
53multicellular organismal reproductive process (GO:0048609)3.68666357
54cellular process involved in reproduction in multicellular organism (GO:0022412)3.68170714
55fertilization (GO:0009566)3.65633432
56cell wall macromolecule catabolic process (GO:0016998)3.61850408
57chromatin silencing (GO:0006342)3.58575613
58regulation of centriole replication (GO:0046599)3.57969176
59seminiferous tubule development (GO:0072520)3.55772717
60organic cation transport (GO:0015695)3.54710694
61cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.54183573
62RNA destabilization (GO:0050779)3.54147152
63regulation of inclusion body assembly (GO:0090083)3.49664489
64urinary tract smooth muscle contraction (GO:0014848)3.42364806
65peptidyl-threonine dephosphorylation (GO:0035970)3.39870657
66coenzyme catabolic process (GO:0009109)3.39011823
67Golgi to endosome transport (GO:0006895)3.37387528
68primary amino compound metabolic process (GO:1901160)3.22893101
69epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.21467381
70pyridine nucleotide biosynthetic process (GO:0019363)3.20038172
71nicotinamide nucleotide biosynthetic process (GO:0019359)3.20038172
72regulation of female gonad development (GO:2000194)3.19024757
73cerebral cortex neuron differentiation (GO:0021895)3.18953734
74cellular response to pH (GO:0071467)3.15474379
75regulation of microtubule-based movement (GO:0060632)3.14888451
76response to acidic pH (GO:0010447)3.02807410
77nucleus organization (GO:0006997)2.95441491
78positive regulation of action potential (GO:0045760)2.95067443
79peristalsis (GO:0030432)2.82186409
80spinal cord motor neuron differentiation (GO:0021522)2.81620488
81homeostasis of number of cells within a tissue (GO:0048873)2.81364623
82regulation of cilium assembly (GO:1902017)2.81243468
83detection of chemical stimulus involved in sensory perception of smell (GO:0050911)2.69701493
84regulation of hippo signaling (GO:0035330)2.69505709
85glomerular visceral epithelial cell development (GO:0072015)2.65798946
86cell recognition (GO:0008037)2.62750576
87nephron epithelium morphogenesis (GO:0072088)2.62187761
88nephron tubule morphogenesis (GO:0072078)2.62187761
89regulation of interleukin-13 production (GO:0032656)2.61818551
90positive regulation of guanylate cyclase activity (GO:0031284)2.60085431
91multicellular organismal development (GO:0007275)2.57508785
92cranial nerve morphogenesis (GO:0021602)2.56339475
93protein K48-linked deubiquitination (GO:0071108)2.55601800
94glomerular epithelial cell development (GO:0072310)2.55079598
95outflow tract septum morphogenesis (GO:0003148)2.54877128
96microtubule nucleation (GO:0007020)2.54848359
97detection of light stimulus involved in sensory perception (GO:0050962)2.51833200
98acrosome reaction (GO:0007340)10.5039400
99sperm motility (GO:0030317)10.1739651
100fusion of sperm to egg plasma membrane (GO:0007342)10.1293611

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.66392883
2EZH2_22144423_ChIP-Seq_EOC_Human3.29541127
3MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.86285399
4DROSHA_22980978_ChIP-Seq_HELA_Human2.45474105
5CTBP2_25329375_ChIP-Seq_LNCAP_Human2.32744193
6TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.12016488
7POU5F1_26923725_Chip-Seq_MESODERM_Mouse2.12016488
8CTBP1_25329375_ChIP-Seq_LNCAP_Human2.09627937
9GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.04237454
10SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.86313472
11IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.85197662
12CBP_20019798_ChIP-Seq_JUKART_Human1.85197662
13VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.81811468
14AR_21572438_ChIP-Seq_LNCaP_Human1.74404793
15ARNT_22903824_ChIP-Seq_MCF-7_Human1.73945385
16EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.71475516
17UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.70318876
18ER_23166858_ChIP-Seq_MCF-7_Human1.68783906
19TAF15_26573619_Chip-Seq_HEK293_Human1.68105559
20ERA_21632823_ChIP-Seq_H3396_Human1.60378711
21ZNF274_21170338_ChIP-Seq_K562_Hela1.55721319
22SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.53666802
23EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.52894558
24WDR5_24793694_ChIP-Seq_LNCAP_Human1.51949148
25VDR_22108803_ChIP-Seq_LS180_Human1.48726338
26EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.48535536
27RAC3_21632823_ChIP-Seq_H3396_Human1.48145818
28SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.45096488
29NANOG_20526341_ChIP-Seq_ESCs_Human1.44499632
30SMAD4_21741376_ChIP-Seq_EPCs_Human1.43638037
31AR_25329375_ChIP-Seq_VCAP_Human1.41568341
32RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.41033297
33FUS_26573619_Chip-Seq_HEK293_Human1.39859833
34OCT4_20526341_ChIP-Seq_ESCs_Human1.39367039
35MYC_19829295_ChIP-Seq_ESCs_Human1.38007293
36EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.36882100
37STAT3_23295773_ChIP-Seq_U87_Human1.36724802
38GBX2_23144817_ChIP-Seq_PC3_Human1.36122305
39PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.35366993
40CTCF_27219007_Chip-Seq_Bcells_Human1.33906744
41ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.33803222
42ELF1_20517297_ChIP-Seq_JURKAT_Human1.33001089
43SMC4_20622854_ChIP-Seq_HELA_Human1.31354451
44SMAD3_21741376_ChIP-Seq_EPCs_Human1.30510892
45TAF2_19829295_ChIP-Seq_ESCs_Human1.29533287
46BCL6_27268052_Chip-Seq_Bcells_Human1.26364747
47P300_19829295_ChIP-Seq_ESCs_Human1.25408940
48E2F1_20622854_ChIP-Seq_HELA_Human1.24681876
49TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.23983794
50SUZ12_27294783_Chip-Seq_ESCs_Mouse1.23721104
51AHR_22903824_ChIP-Seq_MCF-7_Human1.22831986
52SMAD3_21741376_ChIP-Seq_ESCs_Human1.22383748
53BCOR_27268052_Chip-Seq_Bcells_Human1.21780085
54REST_21632747_ChIP-Seq_MESCs_Mouse1.20516310
55AUTS2_25519132_ChIP-Seq_293T-REX_Human1.20510996
56TOP2B_26459242_ChIP-Seq_MCF-7_Human1.19554363
57* TP63_22573176_ChIP-Seq_HFKS_Human1.19529091
58ETV2_25802403_ChIP-Seq_MESCs_Mouse1.18179424
59TP53_18474530_ChIP-ChIP_U2OS_Human1.17437093
60P300_27268052_Chip-Seq_Bcells_Human1.17359317
61PHF8_20622854_ChIP-Seq_HELA_Human1.17237735
62EZH2_27294783_Chip-Seq_ESCs_Mouse1.16731555
63PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.15378813
64CTCF_20526341_ChIP-Seq_ESCs_Human1.14673151
65ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.13672561
66CEBPB_22108803_ChIP-Seq_LS180_Human1.13277290
67P68_20966046_ChIP-Seq_HELA_Human1.13052088
68GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.12619876
69YY1_22570637_ChIP-Seq_MALME-3M_Human1.11786851
70GATA3_21878914_ChIP-Seq_MCF-7_Human1.11663039
71RUNX_20019798_ChIP-Seq_JUKART_Human1.11473270
72ERG_20517297_ChIP-Seq_VCAP_Human1.11189913
73PRDM14_20953172_ChIP-Seq_ESCs_Human1.10580223
74RUNX2_22187159_ChIP-Seq_PCA_Human1.10565801
75KLF5_20875108_ChIP-Seq_MESCs_Mouse1.09876587
76SMAD4_21741376_ChIP-Seq_HESCs_Human1.09851261
77SMAD4_21799915_ChIP-Seq_A2780_Human1.09472371
78SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.09050579
79TDRD3_21172665_ChIP-Seq_MCF-7_Human1.07843030
80OCT1_27270436_Chip-Seq_PROSTATE_Human1.07671280
81STAT6_21828071_ChIP-Seq_BEAS2B_Human1.07249975
82SMRT_27268052_Chip-Seq_Bcells_Human1.06750371
83GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.05637028
84VDR_24787735_ChIP-Seq_THP-1_Human1.05512068
85KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.05281955
86JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.05265935
87TBL1_22424771_ChIP-Seq_293T_Human1.03811351
88TCF4_23295773_ChIP-Seq_U87_Human1.03099677
89JARID2_20075857_ChIP-Seq_MESCs_Mouse1.02631400
90NR3C1_21868756_ChIP-Seq_MCF10A_Human1.02055413
91NANOG_19829295_ChIP-Seq_ESCs_Human1.01965117
92SOX2_19829295_ChIP-Seq_ESCs_Human1.01965117
93ZNF217_24962896_ChIP-Seq_MCF-7_Human1.01791954
94CBX2_22325352_ChIP-Seq_293T-Rex_Human1.01690586
95ETV1_20927104_ChIP-Seq_GIST48_Human1.00871662
96TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.00315383
97TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00248136
98KLF5_25053715_ChIP-Seq_YYC3_Human0.99858772
99* P53_21459846_ChIP-Seq_SAOS-2_Human0.99576328
100LXR_22292898_ChIP-Seq_THP-1_Human0.99390445

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005377_hearing/vestibular/ear_phenot5.47013895
2MP0003878_abnormal_ear_physiology5.47013895
3MP0005670_abnormal_white_adipose4.67128869
4MP0003698_abnormal_male_reproductive3.80111206
5MP0001348_abnormal_lacrimal_gland3.36366991
6MP0001929_abnormal_gametogenesis3.19533606
7MP0003136_yellow_coat_color2.45275530
8MP0003646_muscle_fatigue2.33115226
9MP0001485_abnormal_pinna_reflex2.25295480
10MP0002161_abnormal_fertility/fecundity2.00578093
11MP0005410_abnormal_fertilization10.4831080
12MP0005451_abnormal_body_composition1.96868604
13MP0009053_abnormal_anal_canal1.88365050
14MP0001968_abnormal_touch/_nociception1.84689567
15MP0000678_abnormal_parathyroid_gland1.81510884
16MP0005423_abnormal_somatic_nervous1.78925170
17MP0003718_maternal_effect1.73333856
18MP0005310_abnormal_salivary_gland1.66596879
19MP0003011_delayed_dark_adaptation1.65528214
20MP0002138_abnormal_hepatobiliary_system1.64557030
21MP0002735_abnormal_chemical_nociception1.56075493
22MP0002249_abnormal_larynx_morphology1.53082890
23MP0004742_abnormal_vestibular_system1.52877464
24MP0002132_abnormal_respiratory_system1.49489267
25MP0001486_abnormal_startle_reflex1.44114654
26MP0005551_abnormal_eye_electrophysiolog1.42687756
27MP0005167_abnormal_blood-brain_barrier1.41984246
28MP0002282_abnormal_trachea_morphology1.41425522
29MP0000534_abnormal_ureter_morphology1.39445460
30MP0002210_abnormal_sex_determination1.34156817
31MP0003879_abnormal_hair_cell1.34033791
32MP0000569_abnormal_digit_pigmentation1.31667252
33MP0002822_catalepsy1.27488229
34MP0001963_abnormal_hearing_physiology1.21010844
35MP0001765_abnormal_ion_homeostasis1.19945777
36MP0001501_abnormal_sleep_pattern1.17890012
37MP0000026_abnormal_inner_ear1.17658296
38MP0009046_muscle_twitch1.15219559
39MP0002067_abnormal_sensory_capabilities1.11951614
40MP0004510_myositis1.09805499
41MP0005379_endocrine/exocrine_gland_phen1.08741737
42MP0002733_abnormal_thermal_nociception1.07012438
43MP0004859_abnormal_synaptic_plasticity1.06829219
44MP0001145_abnormal_male_reproductive1.04857393
45MP0000653_abnormal_sex_gland1.01666124
46MP0002229_neurodegeneration1.01333880
47MP0005248_abnormal_Harderian_gland1.00634886
48MP0005253_abnormal_eye_physiology0.99672831
49MP0003950_abnormal_plasma_membrane0.98835490
50MP0001970_abnormal_pain_threshold0.95412798
51MP0009745_abnormal_behavioral_response0.94566139
52MP0002234_abnormal_pharynx_morphology0.94502613
53MP0005395_other_phenotype0.94037058
54MP0005083_abnormal_biliary_tract0.92585653
55MP0002653_abnormal_ependyma_morphology0.92079687
56MP0000955_abnormal_spinal_cord0.88567622
57MP0002928_abnormal_bile_duct0.86508785
58MP0002572_abnormal_emotion/affect_behav0.82226354
59MP0009115_abnormal_fat_cell0.82016073
60MP0005645_abnormal_hypothalamus_physiol0.80537823
61MP0001905_abnormal_dopamine_level0.79163483
62MP0002272_abnormal_nervous_system0.76804308
63MP0002127_abnormal_cardiovascular_syste0.72528570
64MP0004085_abnormal_heartbeat0.72186654
65MP0002557_abnormal_social/conspecific_i0.71682842
66MP0002736_abnormal_nociception_after0.69919385
67MP0000470_abnormal_stomach_morphology0.68619603
68MP0005666_abnormal_adipose_tissue0.68338706
69MP0008569_lethality_at_weaning0.68014457
70MP0000230_abnormal_systemic_arterial0.67945083
71MP0008057_abnormal_DNA_replication0.66915465
72MP0003045_fibrosis0.66497532
73MP0000467_abnormal_esophagus_morphology0.62807057
74MP0005535_abnormal_body_temperature0.62523132
75MP0009764_decreased_sensitivity_to0.62396195
76MP0003631_nervous_system_phenotype0.61408666
77MP0003959_abnormal_lean_body0.60197571
78MP0008961_abnormal_basal_metabolism0.57621595
79MP0003633_abnormal_nervous_system0.56979342
80MP0003632_abnormal_nervous_system0.56293781
81MP0002064_seizures0.54849824
82MP0005174_abnormal_tail_pigmentation0.54450813
83MP0002168_other_aberrant_phenotype0.54306647
84MP0001666_abnormal_nutrient_absorption0.53084777
85MP0003635_abnormal_synaptic_transmissio0.51972951
86MP0001873_stomach_inflammation0.51821484
87MP0005595_abnormal_vascular_smooth0.51330413
88MP0001984_abnormal_olfaction0.51004567
89MP0000681_abnormal_thyroid_gland0.50973581
90MP0010386_abnormal_urinary_bladder0.49926034
91MP0003195_calcinosis0.49684895
92MP0000249_abnormal_blood_vessel0.49428710
93MP0003137_abnormal_impulse_conducting0.48496801
94MP0003638_abnormal_response/metabolism_0.48102429
95MP0005375_adipose_tissue_phenotype0.47288440
96MP0001986_abnormal_taste_sensitivity0.47050181
97MP0002693_abnormal_pancreas_physiology0.46069624
98MP0005647_abnormal_sex_gland0.45836272
99MP0001879_abnormal_lymphatic_vessel0.45587452
100MP0003091_abnormal_cell_migration0.44710049

Predicted human phenotypes

RankGene SetZ-score
1Severe visual impairment (HP:0001141)6.72977187
2Attenuation of retinal blood vessels (HP:0007843)6.15407126
3Absent/shortened dynein arms (HP:0200106)5.81267612
4Dynein arm defect of respiratory motile cilia (HP:0012255)5.81267612
5Bony spicule pigmentary retinopathy (HP:0007737)5.64809229
6Abnormal ciliary motility (HP:0012262)4.86727883
7Asymmetric septal hypertrophy (HP:0001670)4.68078036
8Abnormal respiratory motile cilium physiology (HP:0012261)4.31850163
9Hypoplastic ischia (HP:0003175)4.31132225
10Abnormal respiratory epithelium morphology (HP:0012253)4.21301844
11Abnormal respiratory motile cilium morphology (HP:0005938)4.21301844
12Bell-shaped thorax (HP:0001591)4.17287402
13Chronic hepatic failure (HP:0100626)4.10731388
14Potter facies (HP:0002009)3.83056107
15Facial shape deformation (HP:0011334)3.83056107
16Progressive cerebellar ataxia (HP:0002073)3.82040198
17Hyperkalemia (HP:0002153)3.77176675
18Abnormality of the ischium (HP:0003174)3.75469662
19Abnormal rod and cone electroretinograms (HP:0008323)3.70920779
20Aplasia/Hypoplasia of the pubic bone (HP:0009104)3.69212373
21Male infertility (HP:0003251)3.51579158
22Nasal polyposis (HP:0100582)3.49316879
23Enlarged epiphyses (HP:0010580)3.43384590
24Nephronophthisis (HP:0000090)3.41796665
25Abnormality of macular pigmentation (HP:0008002)3.40175943
26Genetic anticipation (HP:0003743)3.22853717
27Tubulointerstitial nephritis (HP:0001970)3.19145462
28Infertility (HP:0000789)3.15110946
29Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.14543303
30Cone-rod dystrophy (HP:0000548)3.08894407
31Parkinsonism with favorable response to dopaminergic medication (HP:0002548)3.07974149
32Abnormality of the renal medulla (HP:0100957)2.99455535
33Abnormal drinking behavior (HP:0030082)2.95376192
34Polydipsia (HP:0001959)2.95376192
35Impulsivity (HP:0100710)2.91958295
36Postural instability (HP:0002172)2.90449596
37Abnormality of the nasal mucosa (HP:0000433)2.82443455
38Abnormal urine output (HP:0012590)2.82005933
39Amelogenesis imperfecta (HP:0000705)2.81385931
40Cerebellar dysplasia (HP:0007033)2.81202761
41Aplasia/Hypoplasia of the earlobes (HP:0009906)2.81052754
42Congenital sensorineural hearing impairment (HP:0008527)2.80322303
43Resting tremor (HP:0002322)2.70898527
44Epiphyseal dysplasia (HP:0002656)2.69469996
45Portal hypertension (HP:0001409)2.56297333
46Pancreatic cysts (HP:0001737)2.56189382
47Polyuria (HP:0000103)2.49739296
48Abnormality of potassium homeostasis (HP:0011042)2.45492554
49Abnormality of the pubic bones (HP:0003172)2.43688009
50Tubular atrophy (HP:0000092)2.40206814
51Abnormality of the hepatic vasculature (HP:0006707)2.39008278
52Abnormality of renal excretion (HP:0011036)2.38383359
53Decreased central vision (HP:0007663)2.37865731
54Type II lissencephaly (HP:0007260)2.36737485
55Pancreatic fibrosis (HP:0100732)2.36357824
56Stage 5 chronic kidney disease (HP:0003774)2.32723954
57Tubulointerstitial abnormality (HP:0001969)2.29681242
58Truncal obesity (HP:0001956)2.29671968
59Azoospermia (HP:0000027)2.29268010
60Abnormal spermatogenesis (HP:0008669)2.28321813
61Rhinitis (HP:0012384)2.28273596
62Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.24779722
63Hypoplasia of the thymus (HP:0000778)2.15443318
64Abnormality of dental color (HP:0011073)2.10998444
65Cystic liver disease (HP:0006706)2.10108516
66Abnormality of the costochondral junction (HP:0000919)2.02080125
67Congenital stationary night blindness (HP:0007642)2.01413147
68Generalized aminoaciduria (HP:0002909)1.98004652
69Keratoconus (HP:0000563)1.97591128
70Increased corneal curvature (HP:0100692)1.97591128
71Pendular nystagmus (HP:0012043)1.96436736
72Scotoma (HP:0000575)1.95582928
73Renal dysplasia (HP:0000110)1.90549365
74Abnormality of the aortic arch (HP:0012303)1.89239038
75Bulbous nose (HP:0000414)1.89133983
76Renovascular hypertension (HP:0100817)1.88014328
77Photophobia (HP:0000613)1.85763625
78Progressive sensorineural hearing impairment (HP:0000408)1.84371915
79True hermaphroditism (HP:0010459)1.84071371
80Optic nerve hypoplasia (HP:0000609)1.82515225
81Sclerocornea (HP:0000647)1.82329131
82Hypoalphalipoproteinemia (HP:0003233)1.80660526
83Widely patent fontanelles and sutures (HP:0004492)1.80544618
84Bronchiectasis (HP:0002110)1.79866721
85Increased neuronal autofluorescent lipopigment (HP:0002074)1.79767891
86Congenital hepatic fibrosis (HP:0002612)1.78835457
87Macular degeneration (HP:0000608)1.78561952
88Unilateral renal agenesis (HP:0000122)1.78123155
89Abnormality of midbrain morphology (HP:0002418)1.76399710
90Molar tooth sign on MRI (HP:0002419)1.76399710
91Neoplasm of the heart (HP:0100544)1.75653389
92Gaze-evoked nystagmus (HP:0000640)1.74049449
93Abnormality of DNA repair (HP:0003254)1.72773707
94Occipital encephalocele (HP:0002085)1.70788051
95Congenital malformation of the right heart (HP:0011723)1.69555578
96Double outlet right ventricle (HP:0001719)1.69555578
97Abnormality of the epiphysis of the femoral head (HP:0010574)1.69348606
98Anterior segment dysgenesis (HP:0007700)1.69045259
99Ventricular tachycardia (HP:0004756)1.66472485
100Abnormality of the renal cortex (HP:0011035)1.65965869

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PLK46.53802354
2DDR24.94638581
3FRK4.33832980
4TESK14.19709824
5INSRR3.82278104
6STK382.90489504
7PNCK2.56464029
8MAPK152.56355369
9BRD42.29008372
10STK38L2.21087756
11CAMK1G2.17945307
12PIK3CG2.13919062
13CDK122.13562562
14ADRBK22.07935816
15MST1R2.01815827
16PLK22.00203601
17ACVR1B1.87309709
18BMPR1B1.77075057
19PTK2B1.76403047
20PDPK11.57231738
21MAP4K21.55087009
22PDK11.50260947
23WNK11.47680774
24DAPK21.37591755
25PRKD31.28453679
26NTRK31.22205224
27CAMK1D1.17899031
28SIK21.17128225
29CDK71.07503386
30DYRK1B1.02357057
31PRKAA20.96264246
32GRK10.93957254
33PRKG20.86612555
34LATS10.86007111
35MAP3K70.82265072
36STK390.80396656
37MAP2K20.78891294
38OXSR10.77009069
39RPS6KA60.76729148
40WNK40.76399214
41KSR20.74106649
42NEK60.73629555
43RPS6KA20.69794635
44AKT30.63576454
45CAMK10.63316827
46TYRO30.60965174
47MUSK0.59978060
48IKBKB0.58946224
49ZAK0.56385736
50RPS6KA10.55140439
51MTOR0.54713196
52TNK20.54168118
53TXK0.54123944
54ADRBK10.53373536
55RPS6KC10.52740680
56RPS6KL10.52740680
57CAMK40.52648486
58JAK30.52531581
59RIPK40.51982483
60TGFBR10.50809624
61MAP3K110.50342980
62PRKG10.49848177
63BLK0.49759454
64MAP3K20.49469309
65TIE10.48158883
66CDK30.47994585
67CHUK0.47208220
68ROCK10.46009852
69TRPM70.44941346
70MAP3K90.43814317
71TESK20.43548223
72MAPK110.41425121
73GSK3B0.41070448
74CDK40.40411689
75NEK20.39785485
76MAPK10.38172686
77PRKCG0.37617173
78ICK0.36699539
79PINK10.36496645
80SGK2230.36324989
81SGK4940.36324989
82MET0.33854912
83MAPK80.32778075
84MARK20.32290103
85MAP2K10.32175035
86SGK20.30359852
87PRKCZ0.29370070
88TEC0.28569476
89CDK10.26841860
90CDK20.26332319
91PRKCB0.25899566
92CAMK2A0.25783938
93STK30.25673126
94MAP3K80.25378357
95PRKAA10.25126069
96PRKCE0.24508838
97ITK0.23597731
98PKN10.23078391
99LATS20.23021339
100AKT10.22912914

Predicted pathways (KEGG)

RankGene SetZ-score
1Fatty acid biosynthesis_Homo sapiens_hsa000614.64967238
2Synthesis and degradation of ketone bodies_Homo sapiens_hsa000724.50395009
3Olfactory transduction_Homo sapiens_hsa047403.25156274
4ABC transporters_Homo sapiens_hsa020102.62228648
5Butanoate metabolism_Homo sapiens_hsa006502.42781914
6Taste transduction_Homo sapiens_hsa047421.93639406
7Glycerophospholipid metabolism_Homo sapiens_hsa005641.85601686
8Glycerolipid metabolism_Homo sapiens_hsa005611.81993938
9Dorso-ventral axis formation_Homo sapiens_hsa043201.71241182
10Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.69516800
11Nitrogen metabolism_Homo sapiens_hsa009101.56870307
12Phototransduction_Homo sapiens_hsa047441.51939225
13Morphine addiction_Homo sapiens_hsa050321.43034587
14Tryptophan metabolism_Homo sapiens_hsa003801.39343666
15Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.38131462
16Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.35420425
17Salivary secretion_Homo sapiens_hsa049701.32972129
18Nicotine addiction_Homo sapiens_hsa050331.32646525
19Calcium signaling pathway_Homo sapiens_hsa040201.32189791
20Type II diabetes mellitus_Homo sapiens_hsa049301.27433903
21Graft-versus-host disease_Homo sapiens_hsa053321.27418586
22Fatty acid degradation_Homo sapiens_hsa000711.23209722
23Primary bile acid biosynthesis_Homo sapiens_hsa001201.18374290
24Circadian entrainment_Homo sapiens_hsa047131.18287674
25Allograft rejection_Homo sapiens_hsa053301.17014083
26Autoimmune thyroid disease_Homo sapiens_hsa053201.16472760
27Protein digestion and absorption_Homo sapiens_hsa049741.16408881
28Selenocompound metabolism_Homo sapiens_hsa004501.15480041
29Linoleic acid metabolism_Homo sapiens_hsa005911.06705781
30Histidine metabolism_Homo sapiens_hsa003401.03902552
31Vascular smooth muscle contraction_Homo sapiens_hsa042700.99540904
32Bile secretion_Homo sapiens_hsa049760.99405058
33Maturity onset diabetes of the young_Homo sapiens_hsa049500.99308452
34Type I diabetes mellitus_Homo sapiens_hsa049400.97908922
35Glutamatergic synapse_Homo sapiens_hsa047240.97339093
36Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.97216088
37Pancreatic secretion_Homo sapiens_hsa049720.97041670
38Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.92659374
39Carbohydrate digestion and absorption_Homo sapiens_hsa049730.92480426
40Adipocytokine signaling pathway_Homo sapiens_hsa049200.92058931
41Gastric acid secretion_Homo sapiens_hsa049710.91521108
42Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.90521118
43alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.88989926
44GABAergic synapse_Homo sapiens_hsa047270.87954264
45Antigen processing and presentation_Homo sapiens_hsa046120.86192685
46Estrogen signaling pathway_Homo sapiens_hsa049150.85823098
47Serotonergic synapse_Homo sapiens_hsa047260.85559609
48Inositol phosphate metabolism_Homo sapiens_hsa005620.85364343
49cAMP signaling pathway_Homo sapiens_hsa040240.81906889
50Phosphatidylinositol signaling system_Homo sapiens_hsa040700.81007984
51Phenylalanine metabolism_Homo sapiens_hsa003600.80294952
52Fat digestion and absorption_Homo sapiens_hsa049750.79805928
53Steroid hormone biosynthesis_Homo sapiens_hsa001400.79249815
54Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.78213589
55Retinol metabolism_Homo sapiens_hsa008300.76769525
56PPAR signaling pathway_Homo sapiens_hsa033200.76687502
57Renin-angiotensin system_Homo sapiens_hsa046140.72575188
58Aldosterone synthesis and secretion_Homo sapiens_hsa049250.70266974
59Cholinergic synapse_Homo sapiens_hsa047250.69261673
60Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.67665061
61Fatty acid metabolism_Homo sapiens_hsa012120.67319880
62MAPK signaling pathway_Homo sapiens_hsa040100.67220999
63Platelet activation_Homo sapiens_hsa046110.64894742
64Long-term depression_Homo sapiens_hsa047300.64839214
65Hedgehog signaling pathway_Homo sapiens_hsa043400.64566485
66Insulin secretion_Homo sapiens_hsa049110.64180697
67Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.62112659
68Oxytocin signaling pathway_Homo sapiens_hsa049210.61799094
69Chemical carcinogenesis_Homo sapiens_hsa052040.60578724
70Lysine degradation_Homo sapiens_hsa003100.57041949
71Renin secretion_Homo sapiens_hsa049240.56942470
72VEGF signaling pathway_Homo sapiens_hsa043700.56477833
73Influenza A_Homo sapiens_hsa051640.55790215
74cGMP-PKG signaling pathway_Homo sapiens_hsa040220.55494186
75ECM-receptor interaction_Homo sapiens_hsa045120.54134208
76Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.51634196
77Endocytosis_Homo sapiens_hsa041440.49985471
78Tyrosine metabolism_Homo sapiens_hsa003500.49735538
79Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.47927152
80Viral myocarditis_Homo sapiens_hsa054160.47545753
81Ovarian steroidogenesis_Homo sapiens_hsa049130.46069856
82Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.44204840
83beta-Alanine metabolism_Homo sapiens_hsa004100.43906010
84Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.43569550
85Sulfur relay system_Homo sapiens_hsa041220.43404822
86B cell receptor signaling pathway_Homo sapiens_hsa046620.43136353
87Thyroid hormone signaling pathway_Homo sapiens_hsa049190.42235995
88Phospholipase D signaling pathway_Homo sapiens_hsa040720.42146579
89Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.41871826
90Prolactin signaling pathway_Homo sapiens_hsa049170.40568173
91Synaptic vesicle cycle_Homo sapiens_hsa047210.38758185
92Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.37793264
93Intestinal immune network for IgA production_Homo sapiens_hsa046720.36606250
94Ether lipid metabolism_Homo sapiens_hsa005650.35345536
95Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.35285028
96Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.34714579
97Acute myeloid leukemia_Homo sapiens_hsa052210.34392818
98Choline metabolism in cancer_Homo sapiens_hsa052310.33741799
99Arginine and proline metabolism_Homo sapiens_hsa003300.33714457
100Jak-STAT signaling pathway_Homo sapiens_hsa046300.33196684

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